Trauma Healing Promoter

Abstract

The objective is to provide therapeutic drugs that promote wound healing. [Solution] Analysis of Dectin-1 gene-deficient mice revealed that inhibiting Dectin-1 promotes wound healing caused by burns. When laminarin, a Dectin-1 antagonist, or barley β-glucan 30sp was administered to the wound, a significant wound healing promoting effect was observed. Since low molecular weight β-glucan, a Dectin-1 antagonist, has the effect of promoting wound healing, a wound healing promoter containing it as an active ingredient can be provided.

Claims

1. A skin wound healing promoter containing Dectin-1 antagonist, a low-molecular-weight β-glucan, as its active ingredient.

2. The aforementioned low molecular weight β-glucan The skin wound healing promoter according to claim 1, which is laminarin or barley β-glucan 30sp.

3. The skin wound healing promoter according to claim 1 or 2, wherein the wound is a wound that has reached the subcutaneous tissue.

4. The skin wound healing promoter according to claim 1 or 2, wherein the wound is a wound in which treatment with a Dectin-1 antagonist is deemed effective due to inflammatory cytokines and chemokines in the wound or blood.

5. The skin wound healing promoter according to claim 3, wherein the wound is a burn.

6. A skin wound healing promoter according to claim 5, characterized in that it is used in combination with skin grafting.

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