Whitening toothpaste, method for manufacturing the same, and method for whitening teeth

Abstract

This application relates to a teeth whitening toothpaste in which a peroxide and a peroxide activator undergo a Fenton-type reaction to effectively enhance the teeth whitening effect, as well as a method for producing the same and a method for teeth whitening. [Solution] The squeezing container includes a container body, a cover plate, a power-squeezing mechanism, and a partition plate. The container body is provided with an outlet that communicates with a chamber. The chamber is fitted with a partition plate to divide the chamber into at least two sub-chambers along the extending direction of the container body. The sub-chambers communicate with the outlet and each contain a first paste and a second paste separately. The cover plate is detachably connected to the tail of the container body via a connecting mechanism and provides a seal. The power-squeezing mechanism for squeezing out the first and second pastes is built into the container body and is movably connected to the cover plate. The first paste contains a peroxide, and the second paste contains a peroxide activator.

Description

[Technical Field]

[0001] This application relates to the field of oral care, and more specifically to a whitening toothpaste, a method for manufacturing the same, and a method for whitening teeth. [Background technology]

[0002] Tooth discoloration is classified into extrinsic and intrinsic stains. Extrinsic stains refer to stains present in the acquired enamel film on the tooth surface. The main cause of these stains is the presence of an organic film on the tooth surface called the acquired enamel film, which is made up of salivary proteins. When people smoke, drink tea or coffee, or eat colored foods, this acquired enamel film is easily stained by colored substances. If the stained film is not properly removed, various factors in the oral cavity can influence the formation of extrinsic stains on the tooth surface that are difficult to remove.

[0003] The stain removal and whitening effects of oral hygiene products are primarily due to the following three methods.

[0004] 1. Use an abrasive with a high RDA value to remove deposits from the tooth surface through friction. 2. Use a complexing agent to break down, dissolve, and remove stains. Active ingredients include, but are not limited to, sodium phytate, tetrasodium pyrophosphate, and zinc citrate. 3. Whiten teeth using active ingredients.

[0005] Based on their principle of action, polishing agents are mainly classified into two types: physical and chemical. Physical polishing agents, with their various high cleaning powers, achieve the goal of mechanically removing stains by efficiently creating friction and damaging the surface of tooth enamel. Chemical polishing agents include polyphosphates, pyrophosphates, phyticates, and polyethylene glycol.

[0006] The principle of action is as follows: on the one hand, it loosens dense, hard plaque by binding to stains, and then breaks down or directly oxidizes the stains. On the other hand, it serves the purpose of preventing the formation of stains by competitively adsorbing to the surface of the tooth's acquired coating in the early stages of stain formation and reducing the adsorption effect of stains.

[0007] Physical whitening and chemical whitening through complexing have difficulty achieving the desired effect of removing tooth discoloration, and most commercially available whitening toothpastes fall into this category. In view of the above, we propose the present invention. [Overview of the project]

[0008] The embodiments of this application aim to provide a whitening toothpaste, a method for producing the same, and a method for whitening teeth.

[0009] In the first aspect, the present application provides a whitening toothpaste comprising a squeezing container, a first paste, and a second paste, wherein the squeezing container comprises a container body, a cover plate, a power-squeezing mechanism, and a partition plate, the container body comprising a chamber, the container body having an outlet communicating with the chamber, the chamber being fitted with a partition plate for dividing the chamber into at least two sub-chambers along the extending direction of the container body, the sub-chambers communicating with the outlet and each containing the first paste and the second paste separately, the cover plate being detachably connected to the tail of the container body via a connecting mechanism for sealing, the power-squeezing mechanism for squeezing the first paste and the second paste from the chamber out of the outlet being built into the container body and movably connected to the cover plate, the first paste comprising a peroxide and a first carrier applicable to toothpaste, and the second paste comprising a peroxide activator and a second carrier applicable to toothpaste.

[0010] According to the novel whitening toothpaste of the above-described technological form of this application, an excellent whitening effect can be effectively achieved.

[0011] Furthermore, in the above-described technical embodiment of this application, the first paste contains a peroxide, and the second paste contains a peroxide activator. When the peroxide and the peroxide activator come into contact, a Fenton-type reaction occurs, generating free hydroxyl groups. These free hydroxyl groups act on the teeth, enhancing the whitening effect. However, if the peroxide activator and peroxide are present in the same paste, the peroxide and peroxide activator react beforehand and become inactive, resulting in a loss of the whitening effect. In the above-described technical embodiment, this problem is effectively solved and the whitening effect is maintained by housing the first and second pastes separately in separate sub-chambers. Furthermore, when the user uses the product, a power dispensing mechanism squeezes the first and second pastes from the two sub-chambers out the outlet onto the toothbrush (e.g., the toothbrush head). When the user mixes the first and second pastes by brushing their teeth, the peroxide and peroxide activator undergo a Fenton-type reaction, generating free hydroxyl groups. These free hydroxyl groups act on the teeth, effectively enhancing the teeth whitening effect. In other words, the above-described technological form of this application creatively proposes a whitening toothpaste that is "ready to use after mixing," thereby effectively ensuring that the whitening active ingredients in the toothpaste interact and exert their activity at the time of use, achieving a truly effective whitening effect, contributing to an improvement in the whitening effect of teeth, and in particular contributing to the removal of tooth discoloration and the improvement of the whitening effect.

[0012] In other embodiments of this application, the peroxide activator comprises at least one of a low-valence metal salt, tetraacetylethylenediamine, and catalase, wherein the low-valence metal salt comprises at least one of a stannous salt, a cuprous salt, and a ferrous salt.

[0013] In other embodiments of this application, the stannous salt comprises at least one of stannous chloride and stannous fluoride.

[0014] In other embodiments of the present application, the cuprous salt includes at least one of cuprous chloride and cuprous fluoride.

[0015] In other embodiments of the present application, the ferrous salt includes at least one of ferrous chloride, ferrous fluoride and ferrous gluconate.

[0016] In other embodiments of the present application, the peroxide includes at least one of hydrogen peroxide and a complex of hydrogen peroxide.

[0017] Optionally, the complex of hydrogen peroxide includes at least one of a polyvinylpyrrolidone-hydrogen peroxide complex and urea peroxide.

[0018] In other embodiments of the present application, in the first paste, by mass%, the addition amount of the peroxide is 2% to 18%, and the content of hydrogen peroxide in the peroxide is less than 4%.

[0019] In other embodiments of the present application, in the second paste, by mass%, the addition amount of the peroxide activator is 0.01% to 0.62%.

[0020] In other embodiments of the present application, the first paste further includes carboxylic acid esters. Optionally, in the first paste, by mass%, the addition amount of the carboxylic acid esters is 1.0% to 3.0%. Optionally, the carboxylic acid esters include at least one of triacetin, ethyl acetate, propyl acetate and amyl acetate. [[ID=;25]]

[0021] In other embodiments of the present application, the second paste further includes alkaline salts. Optionally, in the second paste, by mass%, the addition amount of the alkaline salts is 0.6% to 8.0%. Optionally, the alkaline salts include at least one of carbonates and bicarbonates. Optionally, the carbonates include at least one of sodium carbonate and potassium carbonate, and the bicarbonates include at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate and calcium bicarbonate.

[0022] In other embodiments of this application, the second paste comprises a carbonate and a bicarbonate, wherein the amount of carbonate added to the second paste is 0.1% to 3.0% by mass and the amount of bicarbonate added is 0.5% to 5%, or the second paste comprises the carbonate, wherein the amount of carbonate added to the second paste is 0.1% to 8.0% by mass, or the second paste comprises bicarbonate, wherein the amount of bicarbonate added to the second paste is 0.5% to 8.0% by mass.

[0023] In other embodiments of this application, the first carrier comprises an abrasive, an emulsifier, a humectant, a thickener, and a pH adjuster, optionally the abrasive comprising at least one of calcium pyrophosphate and abrasive-type silica; optionally the emulsifier comprising at least one of sodium cocoyl methyl taurate, alkyl glycoside, sodium lauroyl sarcosinate, and sodium lauryl sulfate; optionally the humectant comprising at least one of propylene glycol, polyethylene glycols, and glycerin; optionally the thickener comprising at least one of thickening-type silica and polyvinylpyrrolidone; and optionally the pH adjuster comprising disodium hydrogen phosphate.

[0024] In other embodiments of this application, the first paste comprises, by mass%, 2% to 18% peroxide, 10% to 20% abrasive, 1.5% to 2.5% emulsifier, 41% to 60% humectant, 2.1% to 18% thickener, and 0.1% to 1.0% pH adjuster.

[0025] In other embodiments of this application, the second carrier comprises a humectant, a thickener, an abrasive, an emulsifier, and a cariogenic agent, optionally comprising at least one of glycerin, polyethylene glycols, and propylene glycol as the humectant; optionally comprising at least one of thickening-type silica and polyvinylpyrrolidone as the thickener; optionally comprising at least one of abrasive-type silica and calcium pyrophosphate as the abrasive; optionally comprising at least one of sodium cocoyl methyl taurate, alkyl glycoside, sodium lauroyl sarcosinate, and sodium lauryl sulfate as the emulsifier; optionally comprising a fluoride as the cariogenic agent; and optionally comprising sodium fluoride as the cariogenic agent.

[0026] In other embodiments of this application, the second paste comprises, by mass%, 0.01% to 0.62% of a peroxide activator, 67% to 80% of a humectant, 2.1% to 10% of a thickener, 10% to 20% of an abrasive, 1.5% to 2.5% of an emulsifier, and 0.1% to 0.32% of a caries preventive agent.

[0027] In another embodiment of this application, the transmission squeezing mechanism includes a transmission member and a piston, one end of which is movably connected to a cover plate, the transmission member is installed inside the chamber along the extending direction of the container body, the piston is transmitted to the transmission member, and the transmission member drives the piston to move forward or backward along the axial extending direction of the transmission member, thereby achieving the squeezing of a first paste and a second paste.

[0028] In other embodiments of this application, the whitening toothpaste includes a base, the base comprising a base body, a drive component built into the base body, a transmission mechanism built into the base body and connected to the drive component, a control module built into the base body and electrically connected to the drive component, and a power supply module built into the base body and electrically connected to the control module and the drive component, respectively, wherein the transmission mechanism is provided with a connecting component for fixed connection to a transmission squeezing mechanism built into the squeezing container when the base is assembled with the squeezing container, the drive component drives the transmission squeezing mechanism fixedly connected to the connecting component by driving the transmission mechanism, thereby realizing the squeezing of a first paste and a second paste.

[0029] In another embodiment of this application, the transmission mechanism includes a bracket and a transmission member, the transmission member being mounted on the bracket, the output end of a drive component passing through the bracket and connected to the transmission member, and a connecting component being provided at one end of the transmission member away from the output end of the drive component.

[0030] In the second aspect, the present application provides a method for manufacturing a whitening toothpaste, the whitening toothpaste comprising a squeezing container, a first paste, and a second paste, wherein the squeezing container comprises a container body, a cover plate, a transmission squeezing mechanism, and a partition plate, the container body having a chamber, the container body having an outlet communicating with the chamber, the chamber having a partition plate for dividing the chamber into at least two sub-chambers along the extending direction of the container body, the sub-chambers communicating with the outlet and each containing the first paste and the second paste separately, and the cover plate A transmission squeezing mechanism for sealing and squeezing out the first paste and second paste from the chamber through an outlet is built into the container body and movably connected to a cover plate, wherein the first paste contains a peroxide and the second paste contains a peroxide activator, the peroxide activator contains at least one of a low-valence metal salt, tetraacetylethylenediamine and catalase, and this manufacturing method includes the steps of filling one sub-chamber with the first paste and filling the other sub-chamber with the second paste.

[0031] In other embodiments of this application, the low-valence metal salt includes at least one of stannous, cuprous, and ferrous salts.

[0032] In the third aspect, the present application provides a method for whitening teeth, the method for whitening teeth provides a whitening toothpaste, the whitening toothpaste comprises a squeezing container, a first paste, and a second paste, the squeezing container comprises a container body, a cover plate, a transmission squeezing mechanism, and a partition plate, the container body comprises a chamber, the container body is provided with an outlet communicating with the chamber, the chamber is provided with a partition plate for dividing the chamber into at least two sub-chambers along the extending direction of the container body, the sub-chambers communicate with the outlet, the first paste and the second paste each contain one sub-chamber individually, and the cover plate is connected via a connecting mechanism A transmission squeezing mechanism, which is detachably connected to the tail of the container body and seals the chamber, and for squeezing out the first paste and the second paste from the outlet, is built into the container body and is movably connected to the cover plate, wherein the first paste comprises a peroxide and a first carrier applicable to toothpaste, and the second paste comprises a peroxide activator and a second carrier applicable to toothpaste, and the method comprises the steps of applying the first paste and the second paste to an oral care instrument when the first paste and the second paste from the chamber are squeezed out from the outlet by the transmission squeezing mechanism, and cleaning the mouth using the oral care instrument.

[0033] In the fourth aspect, the present application provides a whitening toothpaste comprising a dispenser, a first paste, and a second paste, wherein the dispenser comprises a container body, the container body comprises a chamber, the container body is provided with an outlet communicating with the chamber, the chamber comprises at least two sub-chambers along the extending direction of the container body, the sub-chambers communicating with the outlet and each separately containing the first paste and the second paste, the first paste comprising a peroxide and a first carrier applicable to the toothpaste, and the second paste comprising a peroxide activator and a second carrier applicable to the toothpaste.

[0034] To more clearly describe the technical modes of the embodiments of this application, the drawings necessary for describing the embodiments are briefly described below. The drawings described are only a selection of embodiments of this application and do not limit the scope. Those skilled in the art can obtain other relevant drawings based on these drawings without employing inventive ability. [Brief explanation of the drawing]

[0035] [Figure 1] This is a schematic diagram of the structure of a whitening toothpaste according to an embodiment of this application. [Figure 2] This is a schematic diagram of the structure of a squeezing container according to an embodiment of the present application. [Figure 3] This is a schematic diagram of the base according to the embodiment of this application, viewed from one direction. [Figure 4] This is a schematic diagram of the base according to the embodiment of this application, viewed from a different direction. [Figure 5] This is a 1kx electron microscope image showing the surface morphology of the corresponding bovine tooth before the sealing experiment in Comparative Example 6. [Figure 6] This is a scanning electron microscope image showing the surface morphology of the corresponding bovine tooth before the sealing experiment according to Example 1. [Figure 7] This is a 1kx electron microscope image showing the difference in surface morphology of bovine teeth after the sealing experiment in Comparative Example 6. [Figure 8] This is a 1kx electron microscope image showing the difference in surface morphology of bovine teeth after the sealing experiment according to Example 1. [Modes for carrying out the invention]

[0036] To clarify the purpose, technical modes, and advantages of the embodiments of this application, the technical modes of the embodiments of this application will be described clearly and completely below. It goes without saying that the embodiments described are only a selection of embodiments of this application, and not all embodiments.

[0037] Therefore, the following detailed description of the embodiments of this application is merely to illustrate selected embodiments of this application and does not limit the scope of the application for which protection is sought. All other embodiments that a person skilled in the art could obtain without using their inventive ability based on the embodiments of this application are all within the scope of protection of this application.

[0038] As shown in Figures 1 to 4, the embodiments of this application provide a whitening toothpaste 1.

[0039] This whitening toothpaste 1 comprises a dispensing container 10, a first paste (not shown), and a second paste (not shown).

[0040] The squeezing container 10 includes a container body 100, a cover plate 200, a power-squeezing mechanism, and a partition plate 130.

[0041] The container body 100 includes a chamber 110. The container body 100 is provided with an outlet 120 that communicates with the chamber 110. The chamber 110 is fitted with a partition plate 130 to divide the chamber 110 into at least two sub-chambers 111 that are aligned along the extending direction of the container body 100. The two sub-chambers 111 communicate with the outlet 120 and each contain a first paste and a second paste separately.

[0042] The cover plate 200 is detachably connected to the tail end of the container body 100 via a connection mechanism 300, thereby providing a seal.

[0043] A power dispensing mechanism for squeezing the first paste and second paste from the chamber 110 out of the outlet 120 is built into the container body 100 and is movably connected to the cover plate 200.

[0044] The first paste contains a peroxide, and the second paste contains a peroxide activator.

[0045] In the above-described technology, the first paste contains a peroxide, and the second paste contains a peroxide activator, the peroxide activator containing at least one of a low-valence metal salt, tetraacetylethylenediamine, and catalase. When the peroxide and the peroxide activator come into contact, a Fenton-type reaction occurs, generating free hydroxyl groups. These free hydroxyl groups act on the teeth to enhance the whitening effect. However, if the peroxide activator and peroxide are present in the same paste, the peroxide and peroxide activator react and become inactive beforehand. In the above-described technology, this problem is effectively solved and the whitening effect is maintained by housing the first and second pastes separately in separate sub-chambers. Furthermore, when the user uses the product, a power dispensing mechanism squeezes the first and second pastes from the two sub-chambers out the outlet onto a toothbrush (e.g., the head of a toothbrush). When the user brings the first and second pastes into contact and mixes them through the brushing motion, the peroxide and peroxide activator undergo a Fenton-type reaction, generating free hydroxyl groups. These free hydroxyl groups act on the teeth, effectively enhancing the teeth whitening effect. In other words, the above-described technological embodiment of this application creatively provides a "ready to use" whitening toothpaste, effectively ensuring that the whitening active ingredients in the toothpaste interact and exert their activity at the time of use, thereby achieving a truly effective whitening effect and contributing to an improvement in the teeth whitening effect.

[0046] As an example, taking hydrogen peroxide as an example, the reaction equation when the above peroxide reacts with tetraacetylethylenediamine (TAED), a low-valent metal salt, or catalase is as follows:

[0047] C 10 H 16 O4N2(TAED) + 2H2O2 → 2CH3COOOH (peracetic acid) + C6H 12 O2N2(DAED) 2H2O2 + low-valence ion → high-valence ion + 2OH - +2OH [ka] Furthermore, in the above-described technical embodiment, the cover plate 200 is connected to the tail end of the squeezing container 10 to seal the first paste and second paste in the chamber 110. A power transmission squeezing mechanism for squeezing the first paste and second paste is provided inside the container body 100, and the connection between the cover plate 200 and the power transmission squeezing mechanism allows the cover plate 200 to play a role in positioning and supporting the power transmission squeezing mechanism during the process of squeezing the raw material from the outlet, enabling the power transmission squeezing mechanism to squeeze the first paste and second paste from the outlet more stably and efficiently. The sealing effect of the cover plate 200 improves the problem of the first paste and second paste leaking from the chamber 110 when the power transmission squeezing mechanism squeezes the first paste and second paste, reduces the risk of malfunction of the squeezing container 10, and improves the operational efficiency of squeezing the first paste and second paste by the squeezing container 10.

[0048] Furthermore, in the above-described technological embodiment, the first paste and the second paste are squeezed out from the outlet of the chamber 110 to form a well-formed paste (the first and second pastes are in contact and connected as one, but can be clearly separated). When used, this ensures that the user applies both the first and second pastes to their mouths simultaneously and contributes to the uniform mixing of the first and second pastes in the oral cavity. This thus contributes to the release of active ingredients and the whitening effect in the oral cavity.

[0049] Furthermore, in the above-described technological configuration, the first and second pastes can be "mixed and used immediately," making it gentler, more suitable for the oral environment, and contributing to the protection of the oral mucosa. In contrast, using only a single tube of ordinary peroxide-containing whitening toothpaste, and then adding a peroxide activator (e.g., powder or solution) to the single tube of ordinary peroxide-containing toothpaste during use, results in increased irritation, is unsuitable for the oral mucosa, is very inconvenient to use, and significantly reduces its actual usefulness. Also, applying two types of active substances (e.g., peroxide and peroxide activator powder or solution) directly to the mouth inevitably increases irritation, is unsuitable for the oral mucosa, is very inconvenient to use, and significantly reduces its actual usefulness.

[0050] Furthermore, optionally, in some embodiments of this application, there are two sub-chambers 111, with the first paste and the second paste each being housed in one sub-chamber 111.

[0051] In any other embodiment of this application, the subchambers 111 may be three, four, or five, and so on, but the first and second pastes are always contained separately in two independent subchambers 111, and the remaining subchambers 111 may be configured according to actual needs. Exemplarily, the remaining subchambers 111 may contain other pastes or other non-paste ingredients (e.g., water), or they may be left empty (e.g., empty for personal use by the user).

[0052] Furthermore, in some embodiments of this application, the low-valence metal salt includes at least one of stannous salts, copperous salts, and ferrous salts.

[0053] Exemplary, in some embodiments of this application, the low-valence metal salt is one of stannous, cuprous, or ferrous salts, or in some embodiments of this application, the low-valence metal salt is a mixture of stannous and cuprous salts, or in some embodiments of this application, the low-valence metal salt is a mixture of stannous and ferrous salts, or in some embodiments of this application, the low-valence metal salt is a mixture of cuprous and ferrous salts, and each of the raw materials in each of the above mixtures can be mixed in any proportion.

[0054] In the above-described technological configuration, the stannous salt, cuprous salt, and ferrous salt can all undergo a Fenton-type reaction upon contact with a peroxide, generating free hydroxyl groups. These free hydroxyl groups act on the teeth to enhance the whitening effect.

[0055] As an example, taking stannous salts as an example, when stannous salts come into contact with peroxides, a Fenton-type reaction like the following can occur.

[0056] [ka] As can be seen from the above reaction, stannous salts can come into contact with peroxides to undergo a Fenton-type reaction, generating free hydroxyl groups. These free hydroxyl groups act on the teeth, effectively enhancing the whitening effect and thus improving the teeth whitening effect.

[0057] Furthermore, in some embodiments of this application, the stannous salt comprises at least one of stannous chloride and stannous fluoride.

[0058] Exemplary, in some embodiments of this application, the stannous salt may be either stannous chloride or stannous fluoride, or in some embodiments of this application, the stannous salt may be a mixture of stannous chloride and stannous fluoride, with the two being mixed in any proportion.

[0059] Furthermore, in some embodiments of this application, the cuprous salt comprises at least one of cuprous chloride and cuprous fluoride.

[0060] Exemplary, in some embodiments of this application, the cuprous salt may be either cuprous chloride or cuprous fluoride, or in some embodiments of this application, the cuprous salt may be a mixture of cuprous chloride and cuprous fluoride, and the two may be mixed in any proportion in the mixture.

[0061] Furthermore, in some embodiments of this application, the ferrous salt comprises at least one of ferrous chloride, ferrous fluoride, and ferrous gluconate.

[0062] Exemplary, in some embodiments of this application, the ferrous salt may be one of ferrous chloride, ferrous fluoride, or ferrous gluconate, or in some embodiments of this application, the ferrous salt may be a mixture of ferrous chloride and ferrous fluoride, or in some embodiments of this application, the ferrous salt may be a mixture of ferrous fluoride and ferrous gluconate, or in some embodiments of this application, the ferrous salt may be a mixture of ferrous chloride and ferrous gluconate, or in some embodiments of this application, the ferrous salt may be a mixture of ferrous chloride, ferrous fluoride, and ferrous gluconate, and each raw material in the mixture may be mixed in any proportion.

[0063] Furthermore, in some embodiments of this application, the peroxide includes at least one of hydrogen peroxide and a hydrogen peroxide compound.

[0064] Exemplary, in some embodiments of this application, the peroxide comprises either hydrogen peroxide or a hydrogen peroxide compound, or in some embodiments of this application, the peroxide comprises a mixture of hydrogen peroxide and a hydrogen peroxide compound, and each of the raw materials in the mixture can be mixed in any proportion.

[0065] Furthermore, in some embodiments of this application, the hydrogen peroxide composite comprises at least one of a polyvinylpyrrolidone-hydrogen peroxide composite and urea peroxide.

[0066] Exemplary, in some embodiments of this application, the hydrogen peroxide composite may be a polyvinylpyrrolidone-hydrogen peroxide composite or urea peroxide, or in some embodiments of this application, the hydrogen peroxide composite may be a mixture of polyvinylpyrrolidone-hydrogen peroxide composite and urea peroxide, with each raw material in the mixture being mixed in any proportion.

[0067] Furthermore, in some embodiments of this application, the hydrogen peroxide content in the peroxide is less than 4% by mass, and the amount of peroxide added to the first paste is 2% to 18%.

[0068] Peroxides have excellent bleaching, sterilizing, and deodorizing effects and are used in cold light whitening in dentistry. However, excessive addition can lead to adverse reactions such as acid erosion of teeth and peeling of the oral mucosa. Therefore, oral whitening products using high concentrations of hydrogen peroxide are used in the medical industry, and their usage and dosage are managed by physicians. However, even when using low concentrations (less than 4%) of hydrogen peroxide as a whitening active ingredient in toothpaste, despite the clear limits on the maximum amount that can be used by relevant domestic laws, some product developers use peroxide close to the maximum amount to be added to toothpaste in order to pursue good whitening effects, which may lead to peeling of the oral mucosa.

[0069] In the above-described technical embodiment of this application, in order to achieve a whitening effect equivalent to or better than that under low-concentration peroxide conditions, the peroxide is made ready to use by mixing it with a peroxide activator. This improves the rate of conversion and release of peroxyl radicals and free hydroxyl groups by low-concentration hydrogen peroxide, thereby improving the bleaching and whitening effect of oral care products, as well as having the effect of remineralizing and repairing damaged tooth enamel.

[0070] In the above-described technological configuration, adding 2% to 18% peroxide to the first paste not only contributes to improving the whitening effect, but more importantly, it enables enhanced whitening effects at low concentrations (for example, even if the amount of peroxide added is reduced to 2%, an excellent whitening effect can be obtained).

[0071] Furthermore, optionally and exemplary, in some embodiments of this application, the amount of peroxide added to the first paste is 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3%, 3.5%, 5%, 10%, 15%, 18%, or within the range of any two of the above values.

[0072] Furthermore, in some embodiments of this application, the hydrogen peroxide content in the peroxide is less than 4% by mass, calculated in terms of hydrogen peroxide content in the first paste. This can be obtained by conversion based on the selected raw materials and their properties. For example, if a commercially available PVP-hydrogen peroxide composite with a hydrogen peroxide content of 20% is selected as the raw material for the peroxide, the hydrogen peroxide content in the PVP-hydrogen peroxide composite will be 0.4% to 3.6%. More specifically, the hydrogen peroxide content is within the range of 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 2%, 2.5%, 3%, or any two of the above values.

[0073] Furthermore, in some embodiments of this application, the amount of peroxide activator added to the second paste is 0.01% to 0.62% by mass.

[0074] In the above-described technological configuration, by adding 0.01% to 0.62% of the peroxide activator to the second paste, it is possible to achieve the ability to "use immediately after mixing" with the peroxide in the first paste, and further enhance the whitening effect through a synergistic effect.

[0075] Exemplary examples, in some embodiments of this application, the amount of peroxide activator added is 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.1%, 0.2%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.55%, 0.60%, 0.62%, or within the range of any two of the above values.

[0076] Furthermore, in some embodiments of this application, the first paste comprises carboxylic acid esters.

[0077] Carboxylic acid esters and peroxides do not react in the absence of water, but when they come into contact with water during use, they react to produce peracetic acid, which has a stronger oxidizing power than hydrogen peroxide, thus improving the whitening effect. Furthermore, peracetic acid is unstable and easily decomposes to generate radicals, which oxidize colored substances, causing them to lose their color and further enhancing the teeth whitening effect.

[0078] The reaction equation is as follows as an example:

[0079] [ka] Furthermore, in some embodiments of this application, the carboxylic acid esters include at least one of triacetin, ethyl acetate, propyl acetate, and amyl acetate.

[0080] The following explains, using triacetin as an example, how triacetin and peroxides exert a synergistic effect to improve the whitening effect.

[0081] [ka] In the above reaction, the two substances do not react in the absence of water, but react in the presence of water to produce peracetic acid, which has stronger oxidizing power than hydrogen peroxide. The low concentration of peracetic acid produced is extremely unstable and readily decomposes to generate effective radicals. These radicals can oxidize and bleach colored organic substances, causing them to lose their color. When using the whitening toothpaste according to this application, if water is present in the mouth and the first and second pastes are mixed by brushing, the carboxylic acid esters and peroxides react in the presence of water to produce peracetic acid. The produced peracetic acid is more effective in bleaching teeth, and an effective bleaching effect can be achieved in a short time with a low concentration of peroxide. Furthermore, peracetic acid is unstable and readily decomposes to generate radicals, and these radicals oxidize colored substances adhering to teeth, causing them to lose their color and further improving the teeth whitening effect.

[0082] The reaction between hydrogen peroxide and carboxylic acid esters occurs in the presence of water; it does not react in the absence of water. Furthermore, carboxylic acid esters undergo hydrolysis when mixed with alkaline substances for extended periods, resulting in an unstable composition. Therefore, this problem can be effectively solved by making the mixture ready to use immediately upon mixing.

[0083] Furthermore, optionally and exemplary, in some embodiments of this application, the carboxylic acid esters may be one of triacetin, ethyl acetate, propyl acetate, or amyl acetate, or in some embodiments of this application, the carboxylic acid esters may be a mixture of triacetin and ethyl acetate, or in some embodiments of this application, the carboxylic acid esters may be a mixture of triacetin and propyl acetate, or in some embodiments of this application, the carboxylic acid esters may be a mixture of triacetin and amyl acetate, or in some embodiments of this application, the carboxylic acid esters may be a mixture of triacetin, ethyl acetate, and propyl acetate, or in some embodiments of this application, the carboxylic acid esters may be a mixture of triacetin, ethyl acetate, propyl acetate, and amyl acetate, and each raw material in the mixture may be mixed in any proportion.

[0084] Furthermore, in some embodiments of this application, the amount of carboxylic acid esters added to the first paste is 1.0% to 3.0% by mass.

[0085] In the above-described technological configuration, the amount of carboxylic acid esters added to the first paste is 1.0% to 3.0%, which further enhances the synergistic effect with the peroxide and improves the whitening effect.

[0086] Furthermore, optionally, in some embodiments of this application, the amount of carboxylic acid esters added to the first paste is, exemplary, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, or within the range of any two of the above values.

[0087] Furthermore, in some embodiments of this application, the second paste comprises alkaline salts.

[0088] By containing alkaline salts and peroxides in two separate pastes, the whitening effects of the peroxides and alkaline salts themselves are ensured, making the product "ready to use after mixing." The peroxyl radicals generated by the reaction of the two enhance the whitening effect compared to hydrogen peroxide alone, contributing to further improvement of the whitening effect. Furthermore, the precipitate formed by the Fenton-type reaction with the alkaline salts, consisting of high-valence metal ions, has a dentinal tubule-sealing effect, improving the hardness of tooth enamel. Therefore, the whitening toothpaste according to this application has the effect of remineralizing and repairing damaged tooth enamel.

[0089] Furthermore, optionally, in some embodiments of this application, the alkaline salts include at least one of a carbonate or a bicarbonate.

[0090] Since carbonates or bicarbonates themselves have a whitening effect, they contribute to further enhancing the whitening effect. Furthermore, the combination of carbonates and bicarbonates prevents swelling and contributes to extending the shelf life of toothpaste.

[0091] As an example, the reaction between the above alkaline salts and peroxides is as follows:

[0092] [ka] As can be seen from the above reaction equation, the peroxyl radicals produced by the reaction of hydrogen peroxide and sodium bicarbonate enhance the whitening effect compared to hydrogen peroxide alone. Furthermore, optionally and exemplary, in some embodiments of this application, the alkaline salts may be selected from either a carbonate or a bicarbonate, or in some embodiments of this application, the alkaline salts may be a mixture of a carbonate and a bicarbonate, with each ingredient in the mixture mixed in any proportion.

[0093] Furthermore, in some embodiments of this application, the carbonate comprises at least one of sodium carbonate and potassium carbonate, and the bicarbonate comprises at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate, and calcium bicarbonate.

[0094] Exemplary, in some embodiments of this application, the carbonate may be either sodium carbonate or potassium carbonate, or in some embodiments of this application, the carbonate may be a mixture of sodium carbonate and potassium carbonate, with each ingredient in the mixture being mixed in any proportion.

[0095] Exemplary, in some embodiments of this application, the bicarbonate is selected from one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate, or calcium bicarbonate, or in some embodiments of this application, the bicarbonate is selected from a mixture of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate, and calcium bicarbonate, or in some embodiments of this application, the bicarbonate is selected from a mixture of sodium bicarbonate and potassium bicarbonate, or in some embodiments of this application, the bicarbonate is selected from a mixture of magnesium bicarbonate and calcium bicarbonate, or in some embodiments of this application, the bicarbonate is selected from a mixture of sodium bicarbonate, potassium bicarbonate, and magnesium bicarbonate, and each raw material in the mixture can be mixed in any proportion.

[0096] Furthermore, in some embodiments of this application, the amount of alkaline salts added to the second paste is 0.6% to 3.5% by mass.

[0097] In the above-described technological configuration, the amount of alkaline salts added to the second paste is 0.6% to 3.5%, which further enhances the synergistic effect with the peroxide and improves the whitening effect.

[0098] Exemplary, in some embodiments of this application, the amount of alkaline salts added is 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.5%, 1.6%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, or within the range of any two of the above values.

[0099] Furthermore, in some embodiments of this application, the amount of carbonate added to the second paste is 0.1% to 8.0% by mass.

[0100] In the above-described technological configuration, the amount of carbonate added to the second paste is 0.1% to 8.0%, which further enhances the synergistic effect with other raw materials such as the peroxides mentioned above, thereby further improving the whitening effect.

[0101] Furthermore, in some embodiments of this application, the second paste comprises the carbonate and the bicarbonate.

[0102] In the second paste, the amount of carbonate added is 0.1% to 3.0% by mass, and the amount of bicarbonate added is 0.5% to 5%.

[0103] In the above-described technological configuration, the carbonate and bicarbonate in the second paste can further exhibit synergistic effects with other raw materials such as the peroxides mentioned above, thereby further improving the whitening effect.

[0104] Exemplary, in some embodiments of this application, the amount of carbonate added to the second paste is, in mass%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, or within the range of any two of the above values. Exemplary, in some embodiments of this application, the amount of bicarbonate added to the second paste is, in mass%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 1.8%, 2%, 2.5%, 2.8%, 3%, 3.5%, 3.8%, 4%, 4.5%, 4.8%, 5%, or within the range of any two of the above values.

[0105] Furthermore, in some embodiments of this application, the second paste contains the carbonate, and the amount of the carbonate added to the second paste is 0.1% to 8.0% by mass.

[0106] Furthermore, in some embodiments of this application, the second paste contains the bicarbonate. In the second paste, the amount of bicarbonate added is 0.5% to 8.0% by mass.

[0107] Exemplary, in some embodiments of this application, the amount of bicarbonate added to the second paste is, in mass%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 1.8%, 2%, 2.5%, 2.8%, 3%, 3.5%, 3.8%, 4%, 4.5%, 4.8%, 5%, or within the range of any two of the above values.

[0108] Furthermore, in some embodiments of this application, the first carrier comprises an abrasive, an emulsifier, a humectant, a thickener, and a pH adjuster.

[0109] Furthermore, in some embodiments of this application, the abrasive optionally comprises at least one of calcium pyrophosphate and abrasive-type silica.

[0110] Furthermore, in some embodiments of this application, the emulsifier optionally comprises at least one of sodium cocoyl methyl taurate, alkyl glycoside, sodium lauroyl sarcosinate, and sodium lauryl sulfate.

[0111] Furthermore, in some embodiments of this application, the humectant optionally includes at least one of propylene glycol, polyethylene glycols, and glycerin.

[0112] Furthermore, in some embodiments of this application, the thickener optionally includes at least one of thickening type silica and polyvinylpyrrolidone.

[0113] Furthermore, in some embodiments of this application, the pH adjuster optionally includes disodium hydrogen phosphate.

[0114] Exemplary, in some embodiments of this application, the first paste comprises calcium pyrophosphate, sodium cocoyl methyl taurate, propylene glycol, PVP-hydrogen peroxide complex, polyvinylpyrrolidone, triacetin, thickening silica, disodium hydrogen phosphate, and PEG-1500.

[0115] Furthermore, in some embodiments of this application, the first paste comprises, by mass%, 2% to 18% peroxide, 10% to 20% abrasive, 1.5% to 2.5% emulsifier, 41% to 60% humectant, 2.1% to 18% thickener, and 0.1% to 1.0% pH adjuster.

[0116] For example, the first paste contains, by mass%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, or any two of the above values, abrasives in the range of 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, or any two of the above values, and 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, or any two of the above values. It contains an emulsifier within the range of 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 50%, 52%, 53%, 55%, 56%, 58%, 60%, or any two of the above values, a humectant within the range of 2.1%, 2.2%, 2.5%, 3%, 5%, 8%, 10%, 12%, 15%, 18%, or any two of the above values, and a pH adjuster within the range of 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, or any two of the above values.

[0117] Furthermore, in some embodiments of this application, the second carrier comprises a humectant, a thickener, an abrasive, an emulsifier, and a caries preventive agent.

[0118] Furthermore, in some embodiments of this application, the humectant optionally includes at least one of glycerin, polyethylene glycols, and propylene glycol.

[0119] Furthermore, in some embodiments of this application, the thickener optionally includes at least one of thickening type silica and polyvinylpyrrolidone.

[0120] Furthermore, in some embodiments of this application, the abrasive optionally comprises at least one of abrasive-type silica and calcium pyrophosphate.

[0121] Furthermore, in some embodiments of this application, the emulsifier optionally comprises at least one of sodium cocoyl methyl taurate, alkyl glycoside, sodium lauroyl sarcosinate, and sodium lauryl sulfate.

[0122] Furthermore, in some embodiments of this application, the caries prevention agent optionally comprises a fluoride, and optionally comprises sodium fluoride.

[0123] Furthermore, in some embodiments of this application, the second paste comprises, by mass%, 0.01% to 0.62% of a peroxide activator, 67% to 80% of a humectant, 2.1% to 10% of a thickener, 10% to 20% of an abrasive, 1.5% to 2.5% of an emulsifier, and 0.1% to 0.32% of a caries preventive agent.

[0124] Exemplary, in some embodiments of this application, the second paste comprises, by mass%, 0.01%, 0.02%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.62%, or within the range of any two of the above values; 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, or within the range of any two of the above values; and 2.1%, 2.2%, 2.5%, 2.8%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, or the above. It contains a thickening agent within the range of any two of the above values, an abrasive in 10%, 12%, 15%, 18%, 20%, or within the range of any two of the above values, an emulsifier in 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, or 2.5%, within the range of any two of the above values, and a caries prevention agent in 0.1%, 0.12%, 0.15%, 0.18%, 0.19%, 0.2%, 0.22%, 0.23%, 0.25%, 0.28%, 0.3%, 0.32%, or within the range of any two of the above values.

[0125] Exemplary, in some embodiments of this application, the second paste comprises glycerin (glycerol), PEG-8, thickening silica, polishing silica, sodium cocoyl methyl taurate, polyvinylpyrrolidone, stannous chloride, sodium fluoride, sodium carbonate, and baking soda.

[0126] Furthermore, optionally, in some embodiments of this application, the first and second pastes may further contain sweeteners such as mannitol, sucralose, and trichlorogalactosucrose, as well as flavorings.

[0127] Optionally, the first paste may also contain, by mass, 0.08-0.2% sucralose, 1-15% mannitol, and 0.8-1.4% flavor.

[0128] Optionally, the second paste may contain, by mass, 0.08-0.2% trichlorogalactosucrose and 0.8-1.4% flavor.

[0129] Furthermore, in some embodiments of this application, the transmission squeezing mechanism includes a transmission member and a piston. One end of the transmission member is movably connected to a cover plate, the transmission member is located inside the chamber along the extending direction of the container body, and the piston is transmissionally connected to the transmission member. The transmission member drives the piston to move forward or backward along the axial extending direction of the transmission member, thereby achieving the squeezing of the first paste and the second paste.

[0130] As shown in Figure 2, in some embodiments of this application, the transmission squeezing mechanism includes a transmission member 410 and a piston 420. One end of the transmission member 410 is movably connected to a cover plate 200, and the transmission member 410 is located inside the chamber 110 along the extending direction of the container body 100, and the piston 420 is transmitted to the transmission member 410. The transmission member 410 drives the piston 420 to move forward or backward along the axial extending direction of the transmission member 410, thereby achieving squeezing of the raw material.

[0131] In this embodiment, the transmission in the forward and reverse directions by the transmission member 410 in the transmission squeezing mechanism drives the piston 420 to move forward or backward along the axial extension direction of the transmission member 410, thereby enabling automatic squeezing of the raw material in the chamber 110 by the piston 420.

[0132] Taking the structure of the squeezing container 10 shown in Figures 1 and 2 as an example, a partition plate 130 is installed inside the container body 100, dividing the chamber 110 of the container body 100 into two, forming two independent sub-chambers 111, each containing a first paste and a second paste. To achieve automatic simultaneous squeezing of the toothpaste pastes in the two sub-chambers 111 and to make them ready to use after mixing, in this embodiment, the transmission squeezing mechanism includes two transmission members 410 and two pistons 420, with one transmission member 410 and one piston 420 provided for each sub-chamber 111. The two transmission members 410 can rotate synchronously, driving the two pistons 420 to move forward or backward synchronously. Ultimately, this achieves automatic simultaneous squeezing of toothpaste pastes with different components in the two sub-chambers 111.

[0133] In some embodiments of this application, the power transmission squeezing mechanism may be an electric pusher, the end of which is provided with a piston 420, the piston 420 being pushed forward or backward by the electric pusher to achieve automatic squeezing of toothpaste paste.

[0134] Furthermore, as shown in Figures 3 and 4, in some embodiments of this application, the whitening toothpaste includes a base 11.

[0135] The base 11 includes a base body 12, a drive component 13 built into the base body 12, a transmission mechanism 14 built into the base body 12 and connected to the drive component 13, a control module built into the base body 12 and electrically connected to the drive component 13, and a power supply module built into the base body 12 and electrically connected to the control module and the drive component 13, respectively.

[0136] The transmission mechanism 14 is provided with a connecting component 15 for fixed connection to a transmission squeezing mechanism built into the squeezing container 10 when the base 11 is assembled with the squeezing container 10. The drive component 13 drives the transmission squeezing mechanism fixedly connected to the connecting component 15 by driving the transmission mechanism 14, thereby enabling the squeezing of the first paste and the second paste.

[0137] Furthermore, in some embodiments of this application, the transmission mechanism 14 includes a bracket 141 and a transmission member 142. The transmission member 142 is mounted on the bracket 141, and the output end of the drive component 13 passes through the bracket 141 and is connected to the transmission member 142. A connecting component 15 is provided at one end of the transmission member 142 away from the output end of the drive component 13.

[0138] As shown in Figures 1 to 4, the container body 100 is provided with a switch and an insertion component that is electrically connected to the switch. The insertion component is electrically connected to a conductive component on the base attached to the dispensing container 10 to transmit electrical signals.

[0139] In some embodiments of this application, when the squeezing container 10 is mounted on the base, the drive mechanism is connected to a transmission squeezing mechanism built into the squeezing container 10. When the user touches the switch, the circuits of the squeezing container 10 and the base are made conductive. The control module sends a control command to the drive mechanism in response to the switch signal generated by the user. The drive mechanism receives the command and drives the transmission squeezing mechanism. The rotation of the transmission member 410 pushes the piston forward, thereby achieving automatic simultaneous squeezing of the first paste and the second paste.

[0140] In some embodiments of this application, the whitening toothpaste 1 further includes a cap 800 connected to a container body 100.

[0141] In some embodiments of this application, the base body 12 comprises an engagement assembly 1500. The base body 12 is detachably connected to the squeezing container via the engagement assembly 1500.

[0142] In some embodiments of this application, an extension 16 is provided on the base body 12, and a switch and an insertion component are provided on the extension 16. The switch is provided on one end of the extension 16 that is close to the outlet of the squeezing container.

[0143] Some embodiments of this application provide a method for manufacturing a whitening toothpaste.

[0144] This whitening toothpaste includes a dispenser, a first paste, and a second paste.

[0145] The squeezing container includes a container body, a cover plate, a power-squeezing mechanism, and a partition plate.

[0146] The container body comprises a chamber, and the container body is provided with an outlet that communicates with the chamber. The chamber is fitted with a partition plate to divide the chamber into at least two sub-chambers along the extending direction of the container body, and the sub-chambers communicate with the outlet and each contains a first paste and a second paste separately.

[0147] The cover plate is detachably connected to the tail end of the container body via a connecting mechanism, and provides a seal.

[0148] The power dispensing mechanism for squeezing the first and second pastes from the chamber out the outlet is built into the container body and is movably connected to the cover plate.

[0149] The first paste contains a peroxide, and the second paste contains a peroxide activator.

[0150] The above manufacturing method includes the steps of filling one sub-chamber with a first paste and filling the other sub-chamber with a second paste.

[0151] In some embodiments of this application, the peroxide activator comprises at least one of a low-valence metal salt, tetraacetylethylenediamine, and catalase.

[0152] Some embodiments of this application provide a method for whitening teeth, which provides a whitening toothpaste.

[0153] This whitening toothpaste includes a dispenser, a first paste, and a second paste.

[0154] The squeezing container includes a container body, a cover plate, a power-squeezing mechanism, and a partition plate.

[0155] The container body comprises a chamber, and the container body is provided with an outlet communicating with the chamber. The chamber is fitted with a partition plate for dividing the chamber into at least two sub-chambers along the extending direction of the container body, the two sub-chambers communicating with the outlet, and the first paste and the second paste are each individually housed in one of the sub-chambers.

[0156] The cover plate is detachably connected to the tail end of the container body via a connecting mechanism, thereby providing a seal.

[0157] A power dispensing mechanism for squeezing the first paste and the second paste from the chamber out of the outlet is built into the container body and is movably connected to the cover plate.

[0158] The first paste comprises a peroxide and a first carrier applicable to toothpaste, and the second paste comprises a peroxide activator and a second carrier applicable to toothpaste. This delicious, The procedure includes the steps of applying the first paste and the second paste to an oral care device when the first paste and the second paste in the chamber are squeezed out from the outlet by the transmission squeezing mechanism, and cleaning the mouth using the oral care device.

[0159] Some embodiments of this application provide a squeezing container, a first paste, and a second paste.

[0160] The dispensing container includes a container body. The container body is equipped with a chamber, and the container body is provided with an outlet communicating with the chamber, and the chamber includes at least two sub-chambers along the extending direction of the container body, the sub-chambers communicating with the outlet and each containing a first paste and a second paste separately.

[0161] The first paste comprises a peroxide and a first carrier applicable to toothpaste, and the second paste comprises a peroxide activator and a second carrier applicable to toothpaste.

[0162] In the above-described technical embodiment, the first paste and the second paste can be squeezed out by a squeezing mechanism or manually.

[0163] The features and functions of this application will be described in more detail below with reference to the examples, but all the raw materials used in the examples are commercially available. The production of the first paste and the second paste can be carried out using conventional toothpaste paste manufacturing methods in the art.

[0164] Example 1 A whitening toothpaste comprising a dispensing container, a base, a first paste, and a second paste is provided, the dispensing container and base are shown in Figures 1 to 4. The whitening toothpaste is manufactured by filling the first paste and the second paste into two sub-chambers of the dispensing container and sealing them.

[0165] The composition of the first paste is as follows: propylene glycol 47.82 wt.%, polyvinylpyrrolidone 1.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0 wt.%) 5 wt.%, disodium hydrogen phosphate 0.12 wt.%, PEG-1500 3 wt.%, and triacetin 2.5 wt.%.

[0166] The composition of the second paste is as follows: glycerin 48.46 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 19 wt.%, trichlorogalactosucrose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, stannous chloride 0.3 wt.%, sodium fluoride 0.31 wt.%, flavor 1.1 wt.%, sodium carbonate 1.5 wt.%, and baking soda 1.5 wt.%.

[0167] Example 2 The difference from Example 1 is that the compositions of the first paste and the second paste are different.

[0168] The composition of the first paste is as follows: propylene glycol 52.1 wt.%, polyvinylpyrrolidone 0.5 wt.%, trichlorogalactosucrose 0.1 wt.%, sodium cocoyl methyl taurate 1.5 wt.%, flavor 1.0 wt.%, anhydrous calcium pyrophosphate 10 wt.%, mannitol 20 wt.%, colloidal fumed silica 9.8 wt.%, PVP-H2O2 complex (containing 20 wt.% hydrogen peroxide) 2 wt.%, disodium hydrogen phosphate 1.0 wt.%, PEG-1500 1 wt.%, and triacetin 1 wt.%.

[0169] The composition of the second paste is as follows: glycerin 46.53 wt.%, PEG-400 25 wt.%, silica (thickening type) 8 wt.%, silica (abrasive type) 16 wt.%, trichlorogalactosucrose 0.12 wt.%, sodium cocoyl methyl taurate 2.0 wt.%, polyvinylpyrrolidone 0.1 wt.%, stannous chloride 0.45 wt.%, sodium fluoride 0.1 wt.%, flavor 1.1 wt.%, sodium carbonate 0.1 wt.%, and baking soda 0.5 wt.%.

[0170] Example 3 The difference from Example 1 is that the compositions of the first paste and the second paste are different.

[0171] The composition of the first paste is as follows: propylene glycol 44.82 wt.%, polyvinylpyrrolidone 8.0 wt.%, trichlorogalactosucrose 0.08 wt.%, sodium cocoyl methyl taurate 2.5 wt.%, flavor 1.5 wt.%, anhydrous calcium pyrophosphate 13 wt.%, mannitol 5 wt.%, colloidal fumed silica 1 wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0 wt.%) 15 wt.%, disodium hydrogen phosphate 0.1 wt.%, PEG-1500 4 wt.%, and triacetin 5 wt.%.

[0172] The composition of the second paste is as follows: glycerin 54.49 wt.%, PEG-400 12 wt.%, silica (thickening type) 2 wt.%, silica (abrasive type) 25 wt.%, trichlorogalactosucrose 0.2 wt.%, sodium cocoyl methyl taurate 2.5 wt.%, polyvinylpyrrolidone 2.0 wt.%, stannous chloride 0.01 wt.%, sodium fluoride 0.1 wt.%, flavor 1.1 wt.%, sodium carbonate 0.1 wt.%, and baking soda 0.5 wt.%.

[0173] Example 4 The difference from Example 1 is that the compositions of the first paste and the second paste are different.

[0174] The composition of the first paste is as follows: propylene glycol 45.3 wt.%, polyvinylpyrrolidone 2 wt.%, trichlorogalactosucrose 0.1 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1.5 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 12 wt.%, colloidal fumed silica 5 wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0 wt.%) 10 wt.%, disodium hydrogen phosphate 0.1 wt.%, PEG-1500 4 wt.%, and triacetin 3 wt.%.

[0175] The composition of the second paste is as follows: glycerin 46.12 wt.%, PEG-400 18 wt.%, silica (thickening type) 5 wt.%, silica (abrasive type) 20 wt.%, trichlorogalactosucrose 0.18 wt.%, sodium cocoyl methyl taurate 2.1 wt.%, polyvinylpyrrolidone 1.1 wt.%, stannous chloride 0.2 wt.%, sodium fluoride 0.2 wt.%, flavor 1.1 wt.%, sodium carbonate 2 wt.%, and baking soda 4 wt.%.

[0176] Example 5 The difference from Example 1 is that in the first paste, the PVP-H2O2 composite (containing 20.0 wt.% hydrogen peroxide) is 2 wt.%, PEG-1500 is 2 wt.%, and propylene glycol is 51.82 wt.%, while the other raw materials are the same as in Example 1, and their explanation is omitted.

[0177] Example 6 The difference from Example 1 is that in the first paste, PVP-H2O2 composite (hydrogen peroxide content 20.0 wt.%) is 18 wt.%, PEG-1500 is 1 wt.%, propylene glycol is 37.82 wt.%, and anhydrous calcium pyrophosphate is 14 wt.%, while the other raw materials are the same as in Example 1, and their explanation is omitted.

[0178] Example 7 The difference from Example 1 is that in the first paste, the PVP-H2O2 composite (containing 20.0 wt.% hydrogen peroxide) is 0.5 wt.%, anhydrous calcium pyrophosphate is 16.5 wt.%, and propylene glycol is 52.82 wt.%, while the other raw materials are the same as in Example 1, and their explanation is omitted.

[0179] Example 8 The composition of the first paste is as follows: propylene glycol 50.32 wt.%, polyvinylpyrrolidone 1.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0 wt.%) 5 wt.%, disodium hydrogen phosphate 0.12 wt.%, and PEG-1500 3 wt.%.

[0180] The composition of the second paste is as follows: glycerin 48.15 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 22 wt.%, trichlorogalactosucrose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, stannous chloride 0.3 wt.%, sodium fluoride 0.31 wt.%, and flavor 1.1 wt.%.

[0181] Example 9 Unlike Example 1, the composition of the second paste is as follows: glycerin 48.15 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 22 wt.%, trichlorogalactosucrose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, stannous chloride 0.3 wt.%, sodium fluoride 0.31 wt.%, and flavor 1.1 wt.%.

[0182] Example 10 Unlike Example 1, the composition of the first paste is as follows: propylene glycol 50.32 wt.%, polyvinylpyrrolidone 1.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0 wt.%) 5 wt.%, disodium hydrogen phosphate 0.12 wt.%, and PEG-1500 3 wt.%.

[0183] Example 11 Unlike Example 1, the composition of the second paste is as follows: glycerin 48.15 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 22 wt.%, trichlorogalactose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, tetraacetylethylenediamine 0.3 wt.%, sodium fluoride 0.31 wt.%, and flavor 1.1 wt.%.

[0184] Example 12 Unlike Example 1, the composition of the second paste is as follows: glycerin 48.15 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 22 wt.%, trichlorogalactose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, catalase 0.3 wt.%, sodium fluoride 0.31 wt.%, and flavor 1.1 wt.%.

[0185] Comparative Example 1 The composition of the first paste is 50.32 wt.% propylene glycol, 6.9 wt.% polyvinylpyrrolidone, 0.16 wt.% trichlorogalactosucrose, 2 wt.% sodium cocoyl methyl taurate, 1 wt.% flavor, 15 wt.% anhydrous calcium pyrophosphate, 15 wt.% mannitol, 6.5 wt.% colloidal fumed silica, 0.12 wt.% disodium hydrogen phosphate, and 3 wt.% PEG-1500.

[0186] The composition of the second paste is as follows: glycerin 51.45 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 19 wt.%, trichlorogalactosucrose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, sodium fluoride 0.31 wt.%, and flavor 1.1 wt.%.

[0187] Comparative Example 2 The composition of the first paste is as follows: propylene glycol 50.32 wt.%, polyvinylpyrrolidone 1.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0 wt.%) 5 wt.%, disodium hydrogen phosphate 0.12 wt.%, and PEG-1500 3 wt.%.

[0188] The composition of the second paste is as follows: propylene glycol 47.82 wt.%, polyvinylpyrrolidone 6.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, disodium hydrogen phosphate 0.12 wt.%, PEG-1500 3 wt.%, and triacetin 2.5 wt.%.

[0189] Comparative Example 3 The composition of the first paste is as follows: propylene glycol 50.32 wt.%, polyvinylpyrrolidone 1.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0 wt.%) 5 wt.%, disodium hydrogen phosphate 0.12 wt.%, and PEG-1500 3 wt.%.

[0190] The composition of the second paste is as follows: glycerin 48.45 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 19 wt.% ((silica (general abrasive type) 12 wt.%, silica (high abrasive type) 7 wt.%)), trichlorogalactosucrose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, sodium fluoride 0.31 wt.%, flavor 1.1 wt.%, sodium carbonate 1.5 wt.%, and baking soda 1.5 wt.%.

[0191] Comparative Example 4 The composition of the first paste is as follows: propylene glycol 47.82 wt.%, polyvinylpyrrolidone 6.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, disodium hydrogen phosphate 0.12 wt.%, PEG-1500 3 wt.%, and triacetin 2.5 wt.%.

[0192] The composition of the second paste is as follows: glycerin 48.15 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 22 wt.%, trichlorogalactosucrose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, stannous fluoride 0.3 wt.%, sodium fluoride 0.31 wt.%, and flavor 1.1 wt.%.

[0193] Comparative Example 5 The composition of the first paste is as follows: propylene glycol 47.82 wt.%, polyvinylpyrrolidone 6.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, disodium hydrogen phosphate 0.12 wt.%, PEG-1500 3 wt.%, and triacetin 2.5 wt.%.

[0194] The composition of the second paste is as follows: glycerin 48.45 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 19 wt.% ((silica (general abrasive type) 12 wt.%, silica (high abrasive type) 7 wt.%)), trichlorogalactosucrose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, sodium fluoride 0.31 wt.%, flavor 1.1 wt.%, sodium carbonate 1.5 wt.%, and baking soda 1.5 wt.%.

[0195] Comparative Example 6 The composition of the first paste is as follows: propylene glycol 47.82 wt.%, polyvinylpyrrolidone 1.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0 wt.%) 5 wt.%, disodium hydrogen phosphate 0.12 wt.%, PEG-1500 3 wt.%, and triacetin 2.5 wt.%.

[0196] The composition of the second paste is as follows: glycerin 48.45 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 19 wt.% ((silica (general abrasive type) 12 wt.%, silica (high abrasive type) 7 wt.%)), trichlorogalactosucrose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, sodium fluoride 0.31 wt.%, flavor 1.1 wt.%, sodium carbonate 1.5 wt.%, and baking soda 1.5 wt.%.

[0197] Comparative Example 7 The composition of the first paste is as follows: propylene glycol 50.32 wt.%, polyvinylpyrrolidone 1.9 wt.%, trichlorogalactosucrose 0.16 wt.%, sodium cocoyl methyl taurate 2 wt.%, flavor 1 wt.%, anhydrous calcium pyrophosphate 15 wt.%, mannitol 15 wt.%, colloidal fumed silica 6.5 wt.%, PVP-H2O2 complex (hydrogen peroxide content 20.0 wt.%) 5 wt.%, disodium hydrogen phosphate 0.12 wt.%, and PEG-1500 3 wt.%.

[0198] The composition of the second paste is as follows: glycerin 51.45 wt.%, PEG-400 20 wt.%, silica (thickening type) 5.2 wt.%, silica (abrasive type) 19 wt.% (silica (general abrasive type) 12 wt.%, silica (high abrasive type) 7 wt.%), trichlorogalactosucrose 0.14 wt.%, sodium cocoyl methyl taurate 2 wt.%, polyvinylpyrrolidone 0.8 wt.%, sodium fluoride 0.31 wt.%, and flavor 1.1 wt.%.

[0199] Test Example 1 The whitening effect of toothpaste was tested using examples and comparative examples. The verification of the whitening effect was based on section 7.5, "Test method for decomposition of extrinsic stains," of the industry standard "T / COCIA26-2024 Evaluation of the effectiveness of oral hygiene care products - Evaluation of in vitro effects for prevention and decomposition of extrinsic stains on teeth."

[0200] 1. Collection of irritated saliva After cleaning the oral cavity, human irritant saliva was obtained. After uniform shaking, the upper layer of sediment was discarded, and the saliva was centrifuged to extract the supernatant, which was used as a reserve.

[0201] A hydroxyapatite (HAP) sheet was immersed in human irritant saliva for 1.5 hours in an oven at 2.37°C to allow a protective film to form on its surface, thereby simulating the oral environment.

[0202] 3. Preparation of coloring solution Prepare a 2.5 g / L gastric mucin solution (using deionized water), sterilize it at 121°C, then add coffee, tea, soy sauce, tobacco, etc., sterilize at 115°C for 10 minutes, and let it cool to room temperature for reserve use. Filter before use.

[0203] 4. The HAP sheets were randomly grouped, and after being immersed in saliva, the HAP sheets were soaked in a coloring solution for 16 hours.

[0204] 5. After removing the colored sheets, they were washed with water, dried with absorbent paper, and the whiteness L1 was measured with a colorimeter within 10 minutes. Then, 0.5 g each of sample 1 and sample 2 were weighed and added to a 50 mL plastic centrifuge test tube along with 5 g of distilled water. Immediately after, the colored HAP sheets were added and vortexed in a vortex mixer for 3 minutes (simulating brushing for 3 minutes), then washed with water, dried with absorbent paper, and finally the whiteness L2 was measured with a colorimeter within 10 minutes.

[0205] The difference in whiteness ΔL = L2 - L1 before and after the coloring treatment of the HAP sheets for each group was calculated.

[0206] To compare the technical effects, the change in whiteness of two colored hydroxyapatite sheets after treatment with a solution consisting of the above-mentioned toothpaste samples was tested in parallel.

[0207] The obtained data is shown in Table 1 below.

[0208] [Table 1]

[0209] Furthermore, a whitening effect of △L value ≤ 3 is judged to be weak, a whitening effect of 3 < △L value ≤ 6 is judged to be normal, and a whitening effect of △L value > 6 is judged to be strong.

[0210] The experimental results show that each embodiment exhibits at least an ordinary whitening effect, indicating that the technical embodiment of this application can effectively achieve a whitening effect.

[0211] The ΔL values ​​in Examples 11 and 12 were larger than those in Comparative Example 2, indicating that the peroxide activators tetraacetylethylenediamine and catalase in Examples 11 and 12 promote the release of free radicals when reacted with hydrogen peroxide, thereby enhancing the whitening effect of hydrogen peroxide.

[0212] The ΔL value in Example 8 is larger than that of Comparative Examples 3 and 4, indicating that the whitening enhancement effect of the Fenton-type reaction shown in Example 8 is stronger than that of Comparative Examples 3 and 4. This is due to differences in the ability and rate of releasing peroxyl radicals, free hydroxyl groups, and reactive oxygen species within 3 minutes, with the Fenton-type reaction shown in Example 8 being the most effective.

[0213] Furthermore, comparing Example 9 with Comparative Example 6, it can be seen that the whitening effect of Comparative Example 6 is weaker than that of Example 9, and that the combination of (hydrogen peroxide + triacetin) and (sodium bicarbonate + sodium carbonate) is weaker than the combination of (hydrogen peroxide + triacetin) and stannous fluoride. In Example 1, the combination of (hydrogen peroxide + triacetin) and (stannous fluoride + sodium bicarbonate + sodium carbonate) further improves the whitening effect.

[0214] Data from Examples 5-7 show that while triacetin, stannous chloride, sodium bicarbonate, and sodium carbonate remain unchanged, altering the amount of PVP-H2O2 compound added has a greater impact on the whitening effect. Example 6 showed excellent whitening effects, but it had the highest amount of peroxide added, and its composition was not gentle, leading to significant irritation to the mucous membrane. Exceeding this value may cause mucosal peeling.

[0215] Test Example 2 Superoxide radical (O2 - ) measurement To further verify its whitening effect, a spectrophotometer was used to analyze the reaction of the corresponding active ingredient with superoxide radicals (O2 - The generation and deletion speeds of ) were measured.

[0216] Hydrogen peroxide, through the action of a catalyst (e.g., triacetin, bicarbonate, carbonate, low-valent metal ions), produces superoxide radicals (O2). - ), generates hydroxyl radicals (·OH) and alkylperoxyl radicals (ROO·), O2 -By measuring the generation and elimination rates, the whitening enhancement effect of hydrogen peroxide under different conditions can be indirectly indicated.

[0217] 1. Principle O2 - can react with a hydroxylamine solution to produce NO2 - which can be generated. NH2OH + 2O2 - + H + = NO2 - + H2O2 + H2O NO2 - can generate para-phenolsulfonic acid-azo-α-naphthylamine (red) through a color reaction with sulfanilic acid and α-naphthylamine, and the color reaction is as follows. HOO2S-C6H4-NH3·CH3COOH + HNO2 → HOO2S-C6H4-N2(CH3COO) + H2O Sulfanilic acid Nitrous acid HOO2S-C6H4-N2(CH3COO) + C 10 H7NH2 → HOO2S-C6H4-N2C 10 H6·NH2 + CH3COOH α-Naphthylamine Red azo compound

[0218] This red product has a specific absorption peak at 530 nm. According to the standard curve of the NO2 - color reaction, the absorbance corresponding to 530 nm is converted into the NO2 - concentration, and according to the reaction formula, the stoichiometric value of O2 - is directly obtained, that is, the O2 - concentration is obtained by multiplying the NO2 - concentration by 2.

[0219] 2. Test apparatus [[ID=5^3]] (1) Spectrophotometer (2) Pipettes: 0.5 mL × 1, 1 mL × 2, 2 mL × 4 (3) Test tubes: 5 mL × 1, several 20 mL (4) Constant temperature water bath

[0220] 3. Reagents (1) 65 mmol·L -1 Phosphate buffer, pH 7.8. (2) 17 mmol·L -1 Sulfanilic acid Weigh out 2.94 g of sulfanilic acid, dissolve it in 25 mL of concentrated hydrochloric acid, and then dilute to a final volume of 1000 mL with distilled water. (3) 7 mmol·L -1 α-Naphthylamine Weigh out 1.0 g of α-naphthylamine, dissolve it in 25 mL of glacial acetic acid, and then dilute to 1000 mL with distilled water. (4) 10 mmol·L -1 Hydroxylamine hydrochloride. (5)NaNO2 standard solution Weigh 0.1000g of NaNO2 (AR level), dilute to 100mL with distilled water, shake evenly, then take 5mL and dilute to 1000mL with distilled water to obtain NO2 - This will be a standard solution with a concentration of 5 μg / ml.

[0221] 4. Method (1) Creation of standard flags Take seven 20 mL test tubes, number them, and add the reagents in the order shown in the table below, shaking the test tubes well after each addition of reagent.

[0222] [Table 2]

[0223] After adding the reagents, the test tube was placed in a 30°C water bath and kept warm for 30 minutes to allow the color reaction to develop. The absorbance corresponding to 530 nm was then measured. NO2 - A standard flag was created using concentration as the x-coordinate and the absorbance value corresponding to 530 nm as the y-coordinate.

[0224] (2) O2 - Extraction Weigh 1-2 g of the sample to be tested (the supernatant after the active ingredients of toothpaste in a double tube have reacted for 3 minutes), and add an appropriate amount of 65 mmol / L. -1A phosphate buffer (pH 7.8) was added, the volume was adjusted to 1000 mL, and the supernatant was collected.

[0225] (3) O2 of each sample - Measurement Three test tubes were taken, and 2 mL of the sample extract (supernatant), 1.5 mL of phosphate buffer, and 0.5 mL of hydroxylamine hydrochloride were added to each and mixed. The tubes were then kept warm in a 25°C water bath for 20 minutes. 2.0 mL of the reaction solution was taken from each of the three test tubes and placed into three other test tubes, each containing 17 mmol / L of the solution. -1 2.0 mL of sulfanilic acid, 7 mmol / L -1 2.0 mL of α-naphthylamine was added and the mixture was reacted in a 30°C water bath for 30 minutes. The absorbance of the colored solution corresponding to 530 nm was then measured (the solution in the first test tube, used as a standard flag, was adjusted to zero), and the measurement data was recorded.

[0226] (4) O2 - Calculation of content NO2 corresponding to the sample solution from the standard flag - Determine the concentration of O2 - Convert to the concentration (X), and use the following formula for O2 - The content was calculated. [ka] Here, Vt is the volume of the sample extract (mL), 2 is the dilution ratio of the sample extract at the time of measurement, FW is the weight of the reaction solution after dilution, and Vs is the volume of the sample solution at the time of the color reaction (mL). This method allows O2 - The approximate content (ug / g) was detected. The active ingredients of each comparative example and example were mixed in a 1:1 mass ratio to prepare a solution, which was then tested according to the test method described above. The results are shown in the table below.

[0227] [Table 3]

[0228] From the experimental data in the table above, the amount of O2 released by the examples was - The approximate content is higher than that of each comparative example (except for Comparative Example 6, which showed poor hypersensitivity when tested later). As a result, the hydrogen peroxide used in the examples works synergistically with triacetin, bicarbonate, and low-valent metal ions, and the reaction of the three rapidly releases reactive oxygen species, peroxyl radicals, and hydroxyl radicals, thereby bleaching teeth and improving tooth surface discoloration.

[0229] Test Example 3 Verification of the effect of preventing hypersensitivity

[0230] 1, acid erosion The bovine teeth used in this experiment were fresh. After removing contaminants from their surfaces and washing them, they were placed in deionized water containing 0.05% thymol and stored in a refrigerator at 4°C. In the experiment, the stored fresh bovine teeth were taken, cut into 1cm x 1cm x 2m cubic tooth pieces using a low-speed cutter, and then polished with a grinding machine (600# sandpaper) to remove the enamel and expose the dentin tubules. Two prepared bovine tooth fragments (approximately 0.8 cm × 0.8 cm × 1 mm in size) were acid-eroded in a 6% citric acid solution for 3 minutes. The acid-eroded bovine teeth were then placed in pure water and cleaned in an ultrasonic cleaner for 3 minutes to remove surface material. After drying at room temperature for 24 hours, the permeability of the dentin tubules was measured, and scanning electron microscope images of the surface morphology of the resulting bovine teeth are shown in Figures 1 and 2.

[0231] 2. Exam Acid-eroded bovine tooth fragments were placed in grooves of an acrylic plate. 0.4g each of the toothpaste from Comparative Example 6 and Example 1 were taken and placed on the tooth fragments in the grooves of the acrylic plate. Similarly, 0.8g of water was taken and placed in the grooves of the acrylic plate. The acrylic plate was placed on an electronic balance, and brushing was immediately simulated for 3 minutes using an electric toothbrush (oral-B). After that, it was left for 2 minutes, and the balance was controlled to show a count of approximately 150g. After each brushing, the tooth fragments were washed by shaking in 20mL of deionized water in a constant temperature shaker at 180rpm for 30 seconds, and then stored in artificial saliva at 37°C. The teeth were brushed 8 times a day (after each brushing, the tooth fragments were placed in artificial saliva), and brushing was performed for a total of three days, simulating 14 days of brushing.

[0232] After the brushing experiment was completed, the samples were shaken and rinsed for 2 minutes and then dried. The bovine tooth dentin samples were dried in a 25°C incubator for 24 hours and then observed using a scanning electron microscope (SEM).

[0233] Figures 7 and 8 are 1kx electron microscope images showing the differences in surface morphology of bovine teeth after sealing experiments in Comparative Example 6 and Example 1. Figure 7 shows the scanning electron microscope image of the surface morphology of the bovine teeth obtained in Comparative Example 6, and Figure 5 shows the scanning electron microscope image of the corresponding bovine teeth before the experiment. Figure 8 shows the scanning electron microscope image of the surface morphology of the bovine teeth obtained in Example 1, and Figure 6 shows the scanning electron microscope image of the corresponding bovine teeth before the experiment.

[0234] Under the same experimental conditions, all samples showed some degree of dentin tubule sealing effect. As can be seen in Figure 7, the dentin tubules were completely open. This is because there is no special sealing and remineralizing active ingredient present. Almost none of the dentin pores were completely sealed; they were all open, and a small amount of sealing material remained due to the action of hydrated silica. As can be seen when compared with Figure 8, the overall sealing effect is superior to that in Figure 7 due to the synergistic action of tin ions and carbonate ions produced by the Fenton reaction, and sealing material is formed deposited in the dentin pores, playing a role in reducing tooth sensitivity.

[0235] The foregoing description is merely a preferred embodiment of this application and does not limit it. Those skilled in the art may have various modifications and changes to this application. Any modifications, equivalent substitutions, improvements, etc., made without departing from the spirit and principles of this application shall fall within the scope of protection of this application. [Explanation of Symbols]

[0236] 1…Whitening toothpaste 10... Squeeze container 100... Container body 200... Cover plate 130... Partition plate 110... Chamber 120...Exit 111... Sub-chamber 300...Connection mechanism 410... Transmission component 420... Piston 11…Bass 12…Bass body 13…Drive components 14…Transmission mechanism 15…Connecting parts 16...Extension part 141…Bracket 142... Transmission component 800... Cap 1500…Engagement Assembly

Claims

1. The apparatus includes a squeezing container, a first paste, and a second paste. The aforementioned squeezing container includes a container body, a cover plate, a transmission squeezing mechanism, and a partition plate. The container body comprises a chamber, the container body is provided with an outlet communicating with the chamber, the chamber is provided with a partition plate for dividing the chamber into at least two sub-chambers along the extending direction of the container body, the sub-chambers communicate with the outlet, and the first paste and the second paste are each individually contained in one of the sub-chambers. The cover plate is detachably connected to the tail end of the container body via a connecting mechanism, and provides a seal. The transmission squeezing mechanism for squeezing the first paste and the second paste from the chamber out of the outlet is built into the container body and is movably connected to the cover plate. The first paste comprises a peroxide and a first carrier applicable to toothpaste, and the second paste comprises a peroxide activator and a second carrier applicable to toothpaste. A whitening toothpaste characterized by the following features.

2. The peroxide activator comprises at least one of a low-valence metal salt, tetraacetylethylenediamine, and catalase, wherein the low-valence metal salt comprises at least one of a tin salt, a copper salt, and a ferrous salt. The whitening toothpaste according to feature 1.

3. The aforementioned stannous salt comprises at least one of stannous chloride and stannous fluoride. The whitening toothpaste according to feature 2.

4. The cuprous salt comprises at least one of cuprous chloride and cuprous fluoride. The whitening toothpaste according to feature 2.

5. The aforementioned ferrous salt comprises at least one of ferrous chloride, ferrous fluoride, and ferrous gluconate. The whitening toothpaste according to feature 2.

6. The peroxide comprises at least one of hydrogen peroxide and a hydrogen peroxide compound. Optionally, the hydrogen peroxide composite comprises at least one of a polyvinylpyrrolidone-hydrogen peroxide composite and urea peroxide. The whitening toothpaste according to feature 1.

7. In the first paste, the amount of peroxide added is 2% to 18% by mass, and the hydrogen peroxide content in the peroxide is less than 4%. The whitening toothpaste according to feature 1.

8. In the second paste, the amount of peroxide activator added is 0.01% to 0.62% by mass. The whitening toothpaste according to feature 1.

9. The first paste further comprises carboxylic acid esters, Optionally, in the first paste, the amount of carboxylic acid esters added is 1.0% to 3.0% by mass. Optionally, the carboxylic acid esters include at least one of triacetin, ethyl acetate, propyl acetate, and amyl acetate. The whitening toothpaste according to feature 1.

10. The second paste further contains alkaline salts, Optionally, in the second paste, the amount of alkaline salts added is 0.1% to 8.0% by mass. Optionally, the alkaline salts include at least one of carbonates and bicarbonates. Optionally, the carbonate comprises at least one of sodium carbonate and potassium carbonate, and the bicarbonate comprises at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate, and calcium bicarbonate. The whitening toothpaste according to feature 1.

11. The second paste contains the carbonate and the bicarbonate, wherein, in the second paste, the amount of carbonate added is 0.1% to 3.0% by mass, and the amount of bicarbonate added is 0.5% to 5%, or The second paste contains the carbonate, and in the second paste, the amount of the carbonate added is 0.1% to 8.0% by mass, or The second paste contains the bicarbonate, and the amount of bicarbonate added to the second paste is 0.5% to 8.0% by mass. The whitening toothpaste according to feature 10.

12. The first carrier comprises an abrasive, an emulsifier, a humectant, a thickener, and a pH adjuster. Optionally, the abrasive comprises at least one of calcium pyrophosphate and abrasive silica. Optionally, the emulsifier comprises at least one of sodium cocoyl methyl taurate, alkyl glycoside, sodium lauroyl sarcosinate, and sodium lauryl sulfate. Optionally, the humectant comprises at least one of propylene glycol, polyethylene glycols, and glycerin. Optionally, the thickening agent comprises at least one of thickening-type silica and polyvinylpyrrolidone. Optionally, the pH adjusting agent may contain disodium hydrogen phosphate. The whitening toothpaste according to feature 1.

13. The first paste comprises, by mass%, 2% to 18% of the peroxide, 10% to 20% of an abrasive, 1.5% to 2.5% of an emulsifier, 41% to 60% of a humectant, 2.1% to 18% of a thickener, and 0.1% to 1.0% of a pH adjuster. The whitening toothpaste according to feature 12.

14. The second carrier comprises a humectant, a thickener, an abrasive, an emulsifier, and a caries preventive agent. Optionally, the humectant comprises at least one of glycerin, polyethylene glycols, and propylene glycol. Optionally, the thickening agent comprises at least one of thickening-type silica and polyvinylpyrrolidone. Optionally, the abrasive comprises at least one of abrasive-type silica and calcium pyrophosphate. Optionally, the emulsifier comprises at least one of sodium cocoyl methyl taurate, alkyl glycoside, sodium lauroyl sarcosinate, and sodium lauryl sulfate. Optionally, the caries prevention agent contains fluoride, and optionally, the caries prevention agent contains sodium fluoride. The whitening toothpaste according to feature 1.

15. The second paste comprises, by mass%, 0.01% to 0.62% of the peroxide activator, 67% to 80% of a humectant, 2.1% to 10% of a thickener, 10% to 20% of an abrasive, 1.5% to 2.5% of an emulsifier, and 0.1% to 0.32% of a caries preventive agent. The whitening toothpaste according to feature 14.

16. The aforementioned transmission squeezing mechanism includes a transmission member and a piston, One end of the transmission member is movably connected to the cover plate. The transmission member is installed inside the chamber along the extending direction of the container body. The piston is connected to the transmission member, The transmission member drives the piston to move forward or backward along the axial extension direction of the transmission member, thereby enabling the squeezing out of the first paste and the second paste. A whitening toothpaste according to any one of claims 1 to 15.

17. The aforementioned whitening toothpaste includes a base, The aforementioned base is The base body and The drive components built into the base body, A transmission mechanism built into the base body and connected to the drive component, A control module built into the base body and electrically connected to the drive component, The base body includes a power supply module which is built into the base body and is electrically connected to the control module and the drive component, respectively. The transmission mechanism is provided with a connecting component for fixedly connecting to the transmission squeezing mechanism built into the squeezing container when assembling the base with the squeezing container. The drive component drives the transmission squeezing mechanism, which is fixedly connected to the connecting component, by driving the transmission mechanism, thereby achieving the squeezing of the first paste and the second paste. A whitening toothpaste according to any one of claims 1 to 15.

18. The transmission mechanism includes a bracket and a transmission member, the transmission member being mounted on the bracket, the output end of the drive component passing through the bracket and connected to the transmission member, and the connecting component being provided at one end of the transmission member away from the output end of the drive component. The whitening toothpaste according to feature 17.

19. A method for manufacturing a whitening toothpaste. The whitening toothpaste comprises a dispensing container, a first paste, and a second paste. The aforementioned squeezing container includes a container body, a cover plate, a transmission squeezing mechanism, and a partition plate. The container body comprises a chamber, the container body is provided with an outlet communicating with the chamber, the chamber is provided with a partition plate for dividing the chamber into at least two sub-chambers along the extending direction of the container body, the sub-chambers communicate with the outlet, and the first paste and the second paste are each individually contained in one of the sub-chambers. The cover plate is detachably connected to the tail end of the container body via a connecting mechanism, and provides a seal. The transmission squeezing mechanism for squeezing the first paste and the second paste from the chamber out of the outlet is built into the container body and is movably connected to the cover plate. The first paste contains a peroxide, and the second paste contains a peroxide activator, wherein the peroxide activator contains at least one of a low-valence metal salt, tetraacetylethylenediamine, and catalase. The aforementioned manufacturing method is The process includes the steps of filling one of the sub-chambers with the first paste and filling the other sub-chamber with the second paste. A method for producing a whitening toothpaste characterized by the following features.

20. The low-valence metal salt includes at least one of tin salts, copper salts, and ferrous salts. A method for producing a whitening toothpaste according to feature 19.

21. This is a method of teeth whitening, and it provides teeth whitening toothpaste. The whitening toothpaste comprises a dispensing container, a first paste, and a second paste. The aforementioned squeezing container includes a container body, a cover plate, a transmission squeezing mechanism, and a partition plate. The container body comprises a chamber, the container body is provided with an outlet communicating with the chamber, the chamber is provided with a partition plate for dividing the chamber into at least two sub-chambers along the extending direction of the container body, the sub-chambers communicate with the outlet, and the first paste and the second paste are each individually contained in one of the sub-chambers. The cover plate is detachably connected to the tail end of the container body via a connecting mechanism, and provides a seal. The transmission squeezing mechanism for squeezing the first paste and the second paste from the chamber out of the outlet is built into the container body and is movably connected to the cover plate. The first paste comprises a peroxide and a first carrier applicable to toothpaste, and the second paste comprises a peroxide activator and a second carrier applicable to toothpaste. When the first paste and the second paste in the chamber are squeezed out from the outlet by the transmission squeezing mechanism, the procedure includes the steps of applying the first paste and the second paste to an oral care device and cleaning the mouth using the oral care device. A teeth whitening method characterized by the following.

22. The apparatus includes a squeezing container, a first paste, and a second paste. The aforementioned squeezing container includes the container body, The container body comprises a chamber, the container body is provided with an outlet communicating with the chamber, the chamber includes at least two sub-chambers along the extending direction of the container body, the sub-chambers are communicating with the outlet and each contains the first paste and the second paste separately. The first paste comprises a peroxide and a first carrier applicable to toothpaste, and the second paste comprises a peroxide activator and a second carrier applicable to toothpaste. A whitening toothpaste characterized by the following features.

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