Acetamide-phenylbenzamide derivative and method of use thereof

Abstract

The present invention provides compounds for the regulation of P-glycoprotein and cytochrome P450 (e.g., CYP3A4 and CYP3A5 isoforms) enzymes, which a) significantly improve the bioavailability of substrates of these enzymes, including anticancer drugs, b) overcome multidrug resistance in tumors, and c) reduce serious side effects while improving the delivery of P-glycoprotein substrates to the brain. [Solution] Compounds of formula (I), as well as their prodrugs and pharmaceutically acceptable salts, are provided. Further disclosure relates to pharmaceutical compositions containing the compounds, methods of use, and methods for preparing them. TIFF2026086798000135.tif39128

Description

[Technical Field]

[0001] Related applications This application claims priority and benefits of U.S. Provisional Application No. 63 / 088,778, filed on 7 October 2020, which is incorporated herein by reference in its entirety.

[0002] Areas of disclosure This disclosure relates to acetamide-phenylbenzamide derivatives that have modulatory activity toward P-glycoprotein and / or drug-metabolizing enzymes cytochrome P450 (e.g., CYP3A4 and / or CYP3A5 isoforms) and are useful for the treatment of the human or animal body. This disclosure also relates to methods for preparing these compounds, pharmaceutical compositions comprising them, and their use in the treatment of disorders in which the expression of P-glycoprotein and / or cytochrome P450 isoforms (e.g., CYP3A4 or CYP3A5) is regulated (e.g., cancers that have developed multidrug resistance). This disclosure also relates to the use of the compounds of this disclosure to improve the oral bioavailability of therapeutic agents that are substrates of P-glycoprotein and / or cytochrome P450. This disclosure also relates to the use of the compounds of this disclosure to increase the brain distribution of therapeutic agents that are substrates of P-glycoprotein and / or cytochrome P450. [Background technology]

[0003] background Many anticancer drugs (e.g., vinca alkaloids, anthracyclines, epipodophyllotoxin, paclitaxel, and docetaxel) become ineffective when administered to patients with multidrug resistance (MDR) caused by the presence of overexpressed P-glycoprotein. P-glycoprotein regulates the intracellular accumulation of administered anticancer drugs by pushing them out of tumor cells. The expression of the drug-metabolizing CYP3A4 protein in breast tumors, colorectal tumors, esophageal tumors, and Ewing's sarcomas can suppress the intracellular concentration of anticancer drugs by forming metabolites with reduced antitumor activity. This action of CYP3A4 limits the effectiveness of anticancer drugs or contributes to the development of resistance to them. Modulation of P-glycoprotein and / or cytochrome P450 enzymes (e.g., CYP3A4) in tumor cells can increase the sensitivity of these cells to anticancer drugs.

[0004] P-glycoprotein is expressed in normal, healthy tissues, such as the small intestine. Intestinal P-glycoprotein does not allow its substrates to pass through the epithelial cells lining the intestinal wall, thus reducing the oral bioavailability of these substrates. Furthermore, anticancer drugs may undergo first-pass metabolism by cytochrome P450 enzymes (e.g., CYP3A4 and / or CYP3A5 isoforms) present in the small intestine and liver, further reducing their oral bioavailability. Therefore, it is necessary to improve the bioavailability of anticancer drugs through dual-targeting modulation of both P-glycoprotein and cytochrome P450 enzymes (e.g., CYP3A4 and / or CYP3A5 isoforms).

[0005] Furthermore, the localization of P-glycoprotein in endothelial cells of the blood-brain barrier significantly restricts the transport of P-glycoprotein substrates from the blood to the brain. Movable P-glycoprotein at the blood-brain barrier may be beneficial in the treatment of several central nervous system (CNS) disorders, such as brain tumors like glioblastoma. Conventional P-glycoprotein modulators, such as verapamil and cyclosporine A, cause significant adverse effects (e.g., hypotension and immunosuppression). Therefore, several novel P-glycoprotein modulators, such as piperidine-2-carboxylate, acridine, piperazine-2,5-dione, anthranilic acid, and metanodibenzosverane derivatives, have been developed. However, these newly introduced P-glycoprotein modulators have been reported to exhibit toxicity and other adverse effects. This disclosure relates to further compounds for the modulation of P-glycoprotein and cytochrome P450 (e.g., CYP3A4 and CYP3A5 isoforms) enzymes, arising from the need to provide compounds that a) significantly improve the bioavailability of substrates of these enzymes, including anticancer drugs, b) overcome multidrug resistance in tumors, and c) reduce serious side effects while improving the delivery of P-glycoprotein substrates to the brain. [Overview of the project]

[0006] overview In one aspect, this disclosure provides compounds of formula (I), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026086798000001.tif53128 formula, A is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 is alkoxy, halogen, -CN, -OH, or -NH2; R1 and R4 are each independently H, C 1~6 alkyl, C 2~6 alkenyl, or C 2~6 alkynyl; R2 and R3 are each independently H, C 2~6 alkenyl, C 2~6 alkynyl, -O-C 1~6 alkyl, -O-C 2~6 alkenyl, -O-C 2~6 alkynyl, -C(O)R 11 , -C(O)OR 11 , -C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 , -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, where neither R2 nor R3 is H; R5 and R6 are each independently H, C 1~6 alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, a 3- to 13-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, C 6~10 aryl, a 5- to 13-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, or -C(O)R7, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7s, or, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~105-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6, together with the atom to which they are bonded, form a heterocycline or heteroaryl, then A can also be phenyl. It's not TIFF2026086798000002.tif18128 either.

[0007] In one aspect, this disclosure provides compounds of formula (I'), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026086798000003.tif53128 formula, A is The filename is TIFF2026086798000004.tif22128; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6is alkoxy, halogen, -CN, -OH, or -NH2; R1 and R4 are each independently H, C 1~6 alkyl, C 2~6 alkenyl, or C 2~6 alkynyl; R2 and R3 are each independently H, C 2~6 alkenyl, C 2~6 alkynyl, -O-C 1~6 alkyl, -O-C 2~6 alkenyl, -O-C 2~6 alkynyl, -C(O)R 11 , -C(O)OR 11 , -C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 , -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, where neither R2 nor R3 is H; R5 and R6 are each independently H, C 1~6 alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, a 3- to 13-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, C 6~10 aryl, a 5- to 13-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, or -C(O)R7, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7s, or, R5 and R6, together with the atom to which they are attached, form a 4- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6 together with the atom to which they are bonded form a heterocycline, then A is The filename is TIFF2026086798000005.tif23128.

[0008] In one aspect, this disclosure provides compounds of formula (II), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026086798000006.tif60128 formula, R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2; R1 and R4 are independently H and C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3.

[0009] In one aspect, this disclosure provides compounds that can or may be obtained by methods for preparing the compounds described herein (for example, methods comprising one or more steps described in schemes 1 to 10).

[0010] In one aspect, the present disclosure provides a pharmaceutical composition comprising a compound of the present disclosure, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, and a pharmaceutically acceptable diluent or carrier.

[0011] In one aspect, this disclosure provides intermediates described herein that are suitable for use in methods for preparing the compounds described herein (for example, the intermediates are selected from the intermediates described in Examples 1 to 284).

[0012] In one aspect, the present disclosure provides a method for modulating P-glycoprotein activity (e.g., in vitro or in vivo) and / or cytochrome P450 activity (e.g., in vitro or in vivo) comprising the step of contacting a cell with an effective amount of the compound of the present disclosure, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

[0013] In one aspect, the present disclosure provides a method for treating or preventing a disease or disorder disclosed herein in a subject where such treatment is needed, the method comprising administering to the subject a therapeutically effective amount of a compound of the present disclosure, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, or a pharmaceutically acceptable pharmaceutically composition thereof.

[0014] In one aspect, the present disclosure provides the compounds of the present disclosure, or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof, for use in modulating P-glycoprotein activity (e.g., in vitro or in vivo) and / or cytochrome P450 activity (e.g., in vitro or in vivo).

[0015] In one aspect, the Disclosure provides the compounds of the Disclosure, or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof, for use in treating or preventing the diseases or disorders disclosed herein.

[0016] In one aspect, the present disclosure provides the use of the compounds of the present disclosure, or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof, in the manufacture of pharmaceuticals for modulating P-glycoprotein activity (e.g., in vitro or in vivo) and / or cytochrome P450 activity (e.g., in vitro or in vivo).

[0017] In one aspect, the Disclosure provides the use of the Compounds of the Disclosure, or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof, in the manufacture of a medicament for treating or preventing a disease or disorder disclosed herein.

[0018] In one aspect, the present disclosure provides a method for preparing the compounds of the present disclosure.

[0019] In one aspect, this disclosure provides a method for preparing a compound, comprising one or more steps described herein.

[0020] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art in the field to which this disclosure belongs. In this specification, singular nouns also include plural nouns unless otherwise clearly indicated by the context. Methods and materials similar to or equivalent to those described herein may be used in the practice or testing of this disclosure, but preferred methods and materials are described below. All publications, patent applications, patents, and other references referenced herein are incorporated by reference. References cited herein are not considered prior art of the claimed invention. In case of any conflict, this specification, including definitions, shall prevail. Furthermore, materials, methods, and examples are illustrative only and are not intended to be limiting. In case of any conflict between a chemical structure and the name of a compound disclosed herein, the chemical structure shall prevail.

[0021] [Invention 1001] Compounds of formula (I), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: TIFF2026086798000007.tif53128 formula, A is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2; R1 and R4 are independently H and C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R5 and R6, together with the atom they are bonded to, form a heterocycline or heteroaryl, and A is also phenyl. It's not TIFF2026086798000008.tif18128 either. [Invention 1002] Compounds of formula (I), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: TIFF2026086798000009.tif53128 formula, A is The filename is TIFF2026086798000010.tif22128; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2; R1 and R4 are independently H and C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may also be replaced with; R8 -OH, C1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R5 and R6, together with the atom they are bonded to, form a heterocycline, and A is The filename is TIFF2026086798000011.tif20128. [Invention 1003] Compounds of formula (II), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: TIFF2026086798000012.tif60128 formula, R x and R y These are H and C, which are independent of each other. 1~6Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2; R1 and R4 are independently H and C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. [Invention 1004] R x and R y H and C are independent of each other. 1~6 A compound of the present invention that is alkyl or -OH. [Invention 1005] R1 and R4 are independently H or C 1~6 A compound of the present invention that is alkyl. [Invention 1006] R2 and R3 each operate independently, -OC 1~6 Alkyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, or -C(O)NR 11 -S(O)2R 11 The compound of the present invention 1001 or 1002. [Invention 1007] R5 and R6 are independent of each other, H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10Any of the compounds of the present invention, which is a 5- to 13-membered heteroaryl or -C(O)R7 comprising 1 to 4 heteroatoms selected from aryl, N, O, and S, where the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms. [Invention 1008] R5 and R6 are independent of each other, H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 Any of the compounds of the present invention described above, which are aryl, or 5-13 membered heteroaryls comprising 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms. [Invention 1009] R5 and R6 are independent of each other, H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A compound according to the present invention, which is a 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with one or more R7 atoms. [Invention 1010] Any of the compounds of the present invention, wherein R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl is substituted with one or more R7s. [Invention 1011] Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R. 10 , C1~3 Alkyl, C 2~6 Alkinyl, -O-(CH2) t -R8, C 6~10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, aryl, or heteroaryl is one or more R 10 Any of the compounds of the present invention described above, which may be substituted with. [Invention 1012] Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R. 10 , C 1~3 Alkyl, C 2~6 Alkinyl, C 1~6 Alkoxy, -O-(CH2) t -R8, C 6~10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, aryl, or heteroaryl is one or more R 10 Any of the compounds of the present invention that are substituted with the above. [Invention 1013] R8, -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -N(C) 1~6 Alkyl)2,-S(C 1~6 A compound of the present invention, which is a 3-10 membered heterocyclyl comprising 1-4 heteroatoms selected from alkyl, N, O, and S, or a 5-10 membered heteroaryl comprising 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl may be substituted with one or more R9 atoms. [Invention 1014] R8, -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -N(C) 1~6 Alkyl)2,-S(C 1~6A compound of the present invention, comprising a 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from alkyl, N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl is substituted with one or more R9 atoms. [Invention 1015] Each R9 independently, -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 Any of the compounds of the present invention described above, wherein the heteroaryl or aryl is substituted with one or more halogens or -OH groups. [Invention 1016] Each R9 independently, -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A compound of the present invention, wherein the heteroaryl or aryl is substituted with one or more halogens or -OH groups. [Invention 1017] Each R 10 C 1~6 Alkyl, C 1~6 Any of the compounds of the present invention described above, which are haloalkyl or 5-10 membered heteroaryl compounds containing 1-4 heteroatoms selected from N, O, and S. [Invention 1018] Each R 11 They became independent, H; One or more 3-10 membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6~10 aryl, or 5-10 membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S Even if it is replaced with C 1~6Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1~6 Any of the compounds of the present invention described above, which may be substituted with alkyl or oxo. [Invention 1019] Each R 11 They became independent, H; One or more 3-10 membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6~10 aryl, or 5-10 membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S Even if it is replaced with C 1~6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1~6 Any of the compounds of the present invention described above, which are substituted with alkyl or oxo. [Invention 1020] Each R 11 They became independent, H; One or more 3-10 membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6~10 aryl, or 5-10 membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S Replaced with, C 1~6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1~6 Any of the compounds of the present invention described above, which may be substituted with alkyl or oxo. [Invention 1021] 2 R 11However, together with the atoms to which they are bonded, One or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkynyl, halogen, -CN, -OH, or -NH2 A 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted. A compound of the present invention that forms any of the above-mentioned compounds. [Invention 1022] 2 R 11 However, together with the atoms to which they are bonded, One or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkynyl, halogen, -CN, -OH, or -NH2 4-10 membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, substituted with A compound of the present invention that forms any of the above-mentioned compounds. [Invention 1023] Any of the compounds of the present invention described above, wherein each n is 0. [Invention 1024] Any of the compounds of the present invention, wherein each n is 1. [Invention 1025] Any of the compounds of the present invention, wherein each m is 0. [Invention 1026] Any of the compounds of the present invention, wherein each m is 1. [Invention 1027] Any of the compounds of the present invention, wherein each p is 0. [Invention 1028] Any of the compounds of the present invention described above, wherein each p is 1. [Invention 1029] A compound of the present invention in which neither R2 nor R3 is H. [Invention 1030] If R5 and R6, together with the atom to which they are bonded, form a heterocycline or heteroaryl, then A Any of the compounds of the present invention, other than TIFF2026086798000013.tif18128. [Invention 1031] Compounds of formula (Ia) or (Ib): A compound of the present invention 1001 or 1002, which is TIFF2026086798000014.tif110128, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1032] Compounds of formula (Ic), (Id), or (Ie): A compound of the present invention 1001 or 1002, which is TIFF2026086798000015.tif169128, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1033] Compounds of formula (I-a') or (I-b'): A compound of the present invention 1001 or 1002, which is TIFF2026086798000016.tif110128, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1034] Compound of formula (II-a): TIFF2026086798000017.tif57128, or any compound according to 1001 to 1003 of the present invention, which is a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1035] Compound of formula (II-a'): A compound according to any of the inventions 1001 to 1003, which is TIFF2026086798000018.tif57128, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1036] A compound selected from Table 1, one of the compounds 1001 to 1003 of the present invention. [Invention 1037] A pharmaceutical composition comprising any compound 1001 to 1036 of the present invention, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, and a pharmaceutically acceptable diluent or carrier. [Invention 1038] A method for modulating P-glycoprotein activity and / or cytochrome P450 activity, comprising the step of contacting a cell with an effective amount of any compound from Invention 1001 to 1036 or a pharmaceutical composition of Invention 1037. [Invention 1039] A method for treating or preventing a disease or disorder disclosed herein in a subject where such treatment is necessary, comprising the step of administering to the subject a therapeutically effective amount of any compound 1001 to 1036 of the present invention or a pharmaceutical composition of the present invention 1037. [Invention 1040] A method for treating or preventing cancer in a subject in need, comprising the step of administering to the subject a therapeutically effective amount of any compound from 1001 to 1036 of the present invention or a pharmaceutical composition of 1037 of the present invention. [Invention 1041] A compound from any of Invention 1001 to 1036 or a pharmaceutical composition from Invention 1037 for use in modulating P-glycoprotein activity and / or cytochrome P450 activity. [Invention 1042] A compound of any of Invention 1001 to 1036 or a pharmaceutical composition of Invention 1037 for use in treating or preventing any of the diseases or disorders disclosed herein. [Invention 1043] A compound of any of Invention 1001 to 1036 or a pharmaceutical composition of Invention 1037 for use in treating or preventing cancer. [Invention 1044] Use of any compound from Invention 1001 to 1036 or a pharmaceutical composition of Invention 1037 in the manufacture of a pharmaceutical for modulating P-glycoprotein activity and / or cytochrome P450 activity. [Invention 1045] Use of any compound from Invention 1001 to 1036 or a pharmaceutical composition of Invention 1037 in the manufacture of a medicament for treating or preventing a disease or disorder disclosed herein. [Invention 1046] Use of any compound from Invention 1001 to 1036 or a pharmaceutical composition of Invention 1037 in the manufacture of a medicine for treating or preventing cancer. Other features and advantages of this disclosure will be apparent from the following detailed description and claims. [Modes for carrying out the invention]

[0022] Detailed explanation This disclosure arises from the need to provide further compounds for modulating P-glycoprotein and / or cytochrome P450 (e.g., CYP3A4 and / or CYP3A5 isoform) enzymes, which significantly improve the bioavailability of drugs that are substrates of P-glycoprotein and / or cytochrome P450 (e.g., CYP3A4 and / or CYP3A5 isoform) enzymes, while reducing serious adverse effects, including anticancer agents, antihypertensive agents, antiarrhythmic agents, HIV protease inhibitors, antibiotics, antifungal agents, immunosuppressants, antidepressants, neuroleptics, antiepileptic agents, antacids, opioids, and antiemetics. The compounds of this disclosure may also be useful in overcoming multidrug resistance caused by P-glycoprotein and / or cytochrome P450 (e.g., CYP3A4) in cancer cells. The compounds of this disclosure may be useful in improving the efficacy of drugs in brain diseases (e.g., brain tumors) by regulating P-glycoprotein at the blood-brain barrier, thereby enabling drug permeability to the brain. The compounds of this disclosure may also be useful in regulating enterohepatic recirculation of P-glycoprotein substrate drugs (e.g., irinotecan) that are affected by this phenomenon, by regulating P-glycoprotein in bile canaliculi. The compounds of this disclosure may also be useful in influencing the renal excretion of substrate drugs by regulating P-glycoprotein expressed in renal proximal tubular cells.

[0023] Compounds of the Disclosure In one aspect, this disclosure provides compounds of formula (I), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026086798000019.tif48128 formula, A is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R yThese are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2; R1 and R4 are independently H and C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~105-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R5 and R6, together with the atom they are bonded to, form a heterocycline or heteroaryl, and A is also phenyl. It's not TIFF2026086798000020.tif18128 either.

[0024] In one aspect, this disclosure provides compounds of formula (I'), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026086798000021.tif53128 formula, A is The filename is TIFF2026086798000022.tif22128; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6It is an alkoxy, halogen, -CN, -OH, or -NH2; R1 and R4 are independently H and C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R5 and R6, together with the atom they are bonded to, form a heterocycline, and A is The filename is TIFF2026086798000023.tif20128.

[0025] In one aspect, this disclosure provides compounds of formula (II), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026086798000024.tif60128 formula, R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2; R1 and R4 are independently H and C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3.

[0026] For compounds of formula (I), (I'), or (II), A, R x、 R y , R1, R2, R3, R4, R5, R6, R7, R8, R9, R 10 , R 11n, m, p, t, and u can be appropriately selected from the bases described herein, and A, R x、 R y , R1, R2, R3, R4, R5, R6, R7, R8, R9, R 10 , R 11 A, R x、 R y , R1, R2, R3, R4, R5, R6, R7, R8, R9, R 10 , R 11 It will be understood that one or more of the remaining n, m, p, t, and u can be appropriately combined with any of the bases described herein.

[0027] In some embodiments, the N atom of the compound is an N-oxide.

[0028] In some embodiments, N-oxide is formula It has TIFF2026086798000025.tif16128, and in the formula, TIFF2026086798000026.tif9128 shows the binding to compounds of formula (I), (I'), or (II).

[0029] In some embodiments, N-oxide is formula It has TIFF2026086798000027.tif14128, and in the formula, TIFF2026086798000028.tif9128 shows the binding to compounds of formula (I), (I'), or (II).

[0030] In some embodiments, N-oxide is formula It has TIFF2026086798000029.tif15128, and in the formula, TIFF2026086798000030.tif9128 shows the binding to compounds of formula (I), (I'), or (II).

[0031] In some aspects, A is C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo.

[0032] In some aspects, A is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0033] In some aspects, A is C 3~10 A cycloalkyl or a 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline may be substituted with an oxo.

[0034] In some aspects, A is C 3~10 It is a cycloalkyl or a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0035] In some embodiments, C may be substituted with an oxo. 3~10 It is a cycloalkyl group.

[0036] In some embodiments, A is a C3 cycloalkyl group. In some embodiments, A is a C4 cycloalkyl group. In some embodiments, A is a C5 cycloalkyl group. In some embodiments, A is a C6 cycloalkyl group. In some embodiments, A is a C7 cycloalkyl group. In some embodiments, A is a C8 cycloalkyl group. In some embodiments, A is a C9 cycloalkyl group. In some embodiments, A is a C 10 It is a cycloalkyl group.

[0037] In some embodiments, A is a C3 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C4 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C5 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C6 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C7 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C8 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C9 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C 10 It is a cycloalkyl group.

[0038] In some embodiments, A is a C3-C7 monocyclic cycloalkyl. In some embodiments, A is a C3-C7 monocyclic saturated cycloalkyl. In some embodiments, A is a C3-C7 monocyclic partially saturated cycloalkyl. In some embodiments, A is a C9-C 10 It is a bicyclic cycloalkyl. In some embodiments, A is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, A is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, A is C8~C 10 It is a polycyclic cycloalkyl group.

[0039] In some embodiments, A is a C3-C7 monocyclic cycloalkyl that may be oxo-substituted. In some embodiments, A is a C3-C7 monocyclic saturated cycloalkyl that may be oxo-substituted. In some embodiments, A is a C3-C7 monocyclic partially saturated cycloalkyl that may be oxo-substituted. In some embodiments, A is a C9-C7 monocyclic cycloalkyl that may be oxo-substituted. 10 It is a bicyclic cycloalkyl. In some embodiments, A may be substituted with an oxo molecule. C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, A may be substituted with an oxo molecule. C9-C 10It is a bicyclic partially saturated cycloalkyl. In some embodiments, A may be substituted with an oxo C8-C 10 It is a polycyclic cycloalkyl group.

[0040] In some embodiments, A is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0041] In some embodiments, A is a 3- to 10-membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0042] In some embodiments, A is a three-membered heterocycline containing one heteroatom selected from N, O, and S. In some embodiments, A is a four-membered heterocycline containing one to two heteroatoms selected from N, O, and S. In some embodiments, A is a five-membered heterocycline containing one to three heteroatoms selected from N, O, and S. In some embodiments, A is a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is an eight-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is a nine-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is a ten-membered heterocycline containing one to four heteroatoms selected from N, O, and S.

[0043] In some embodiments, A is a three-membered heterocycline containing one heteroatom selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a four-membered heterocycline containing one to two heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a five-membered heterocycline containing one to three heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is an eight-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a nine-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is a ten-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0044] In some embodiments, A is a 7-10 membered bicyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0045] In some embodiments, A is a 7-10 membered bicyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0046] In some embodiments, A is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0047] In some embodiments, A is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0048] In some embodiments, A is an 8-10 membered polycyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0049] In some embodiments, A is an 8-10 membered polycyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0050] In some aspects, A is C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0051] In some aspects, A is C 6~10It is an aryl compound. In some embodiments, A is a C5-C6 aryl compound. In some embodiments, A is a phenyl compound.

[0052] In some embodiments, A is a 5-10 membered heteroaryl compound containing 1-4 heteroatoms selected from N, O, and S.

[0053] In some embodiments, A is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0054] In some embodiments, A is a 9-10 membered bicyclic heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0055] In some embodiments, A is a nine-membered bicyclic heteroaryl compound containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is a ten-membered bicyclic heteroaryl compound containing one to four heteroatoms selected from N, O, and S.

[0056] In some embodiments, A is a 9-10 membered polycyclic heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0057] In some aspects, A is The filename is TIFF2026086798000031.tif22128.

[0058] In some aspects, A is The filename is TIFF2026086798000032.tif21128.

[0059] In some aspects, A is The filename is TIFF2026086798000033.tif15128.

[0060] In some aspects, A is The filename is TIFF2026086798000034.tif15128.

[0061] In some embodiments, R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0062] In some embodiments, R x and R y These are H.

[0063] In some embodiments, R x and R y Each is independent of C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0064] In some embodiments, R x and R y These are H and C, which are independent of each other. 1~6 It is alkyl or -OH.

[0065] In some embodiments, R x H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0066] In some embodiments, R x H is H.

[0067] In some embodiments, R x is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0068] In some embodiments, R x is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, or C 1~6 It is an alkoxy.

[0069] In some embodiments, R x is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0070] In some embodiments, R x is C 1~6 It is alkyl. In some embodiments, R x is methyl. In some embodiments, R x is ethyl. In some embodiments, R x is propyl. In some embodiments, R x is butyl. In some embodiments, R x is pentyl. In some embodiments, R x is hexyl. In some embodiments, R x is isopropyl. In some embodiments, R x isobutyl. In some embodiments, R x is isopentyl. In some embodiments, R x is isohexyl. In some embodiments, R xis secbutyl. In some embodiments, R x secpentyl is secpentyl. In some embodiments, R x is sec hexyl. In some embodiments, R x It is tert-butyl.

[0071] In some embodiments, R x is C 2~6 It is an alkenil. In some embodiments, R x is a C2 alkenyl. In some embodiments, R x is a C3 alkenyl. In some embodiments, R x is a C4 alkenyl. In some embodiments, R x is a C5 alkenyl. In some embodiments, R x This is a C6 alkenyl.

[0072] In some embodiments, R x is C 2~6 It is alkinyl. In some embodiments, R x is C2 alkynyl. In some embodiments, R x is C3 alkynyl. In some embodiments, R x is C4 alkynyl. In some embodiments, R x is C5 alkynyl. In some embodiments, R x This is a C6 alkynyl.

[0073] In some embodiments, R x is C 1~6 It is an alkoxy. In some embodiments, R x is methoxy. In some embodiments, R x is ethoxy. In some embodiments, R x is a propoxy. In some embodiments, R x is butoxy. In some embodiments, R x is pentoxy. In some embodiments, R x It is hexoxy.

[0074] In some embodiments, Rx These are halogens, -CN, -OH, or -NH2.

[0075] In some embodiments, R x is a halogen. In some embodiments, R x is F, Cl, Br, or I. In some embodiments, R x is F, Cl, or Br. In some embodiments, R x is F. In some embodiments, R x is Cl. In some embodiments, R x is Br. In some embodiments, R x It is I.

[0076] In some embodiments, R x is -CN. In some embodiments, R x is -OH. In some embodiments, R x It is -NH2.

[0077] In some embodiments, each R x H, C 1~6 It is alkyl or -OH.

[0078] In some embodiments, R y H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0079] In some embodiments, R y H is H.

[0080] In some embodiments, R y is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0081] In some embodiments, Ry is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, or C 1~6 It is an alkoxy.

[0082] In some embodiments, R y is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0083] In some embodiments, R y is C 1~6 It is alkyl. In some embodiments, R y is methyl. In some embodiments, R y is ethyl. In some embodiments, R y is propyl. In some embodiments, R y is butyl. In some embodiments, R y is pentyl. In some embodiments, R y is hexyl. In some embodiments, R y is isopropyl. In some embodiments, R y isobutyl. In some embodiments, R y is isopentyl. In some embodiments, R y is isohexyl. In some embodiments, R y is secbutyl. In some embodiments, R y secpentyl is secpentyl. In some embodiments, R y is sec hexyl. In some embodiments, R y It is tert-butyl.

[0084] In some embodiments, R y is C 2~6 It is an alkenil. In some embodiments, R y is a C2 alkenyl. In some embodiments, R y is a C3 alkenyl. In some embodiments, R y is a C4 alkenyl. In some embodiments, Ry is a C5 alkenyl. In some embodiments, R y is a C6 alkenyl.

[0085] In some embodiments, R y is C 2~6 alkynyl. In some embodiments, R y is a C2 alkynyl. In some embodiments, R y is a C3 alkynyl. In some embodiments, R y is a C4 alkynyl. In some embodiments, R y is a C5 alkynyl. In some embodiments, R y is a C6 alkynyl.

[0086] In some embodiments, R y is C 1~6 alkoxy. In some embodiments, R y is methoxy. In some embodiments, R y is ethoxy. In some embodiments, R y is propoxy. In some embodiments, R y is butoxy. In some embodiments, R y is pentyloxy. In some embodiments, R y is hexyloxy.

[0087] In some embodiments, R y is halogen, -CN, -OH, or -NH2.

[0088] In some embodiments, R y is halogen. In some embodiments, R y is F, Cl, Br, or I. In some embodiments, R y is F, Cl, or Br. In some embodiments, R y is F. In some embodiments, R y is Cl. In some embodiments, R y is Br. In some embodiments, R y is I.

[0089] In some embodiments, R y is -CN. In some embodiments, R y is -OH. In some embodiments, R y It is -NH2.

[0090] In some embodiments, each R y H, C 1~6 It is alkyl or -OH.

[0091] In some embodiments, R1 and R4 are independently H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0092] In some embodiments, R1 and R4 are H independently.

[0093] In some embodiments, R1 and R4 are independent of each other, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0094] In some embodiments, R1 and R4 are independently H or C 1~6 It is alkyl.

[0095] In some embodiments, R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0096] In some embodiments, R1 is H.

[0097] In some embodiments, R1 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0098] In some embodiments, R1 is C 1~6It is alkyl. In some embodiments, R1 is methyl. In some embodiments, R1 is ethyl. In some embodiments, R1 is propyl. In some embodiments, R1 is butyl. In some embodiments, R1 is pentyl. In some embodiments, R1 is hexyl. In some embodiments, R1 is isopropyl. In some embodiments, R1 is isobutyl. In some embodiments, R1 is isopentyl. In some embodiments, R1 is isohexyl. In some embodiments, R1 is sec-butyl. In some embodiments, R1 is sec-pentyl. In some embodiments, R1 is sec-hexyl. In some embodiments, R1 is tert-butyl.

[0099] In some embodiments, R1 is C 2~6 It is an alkenyl. In some embodiments, R1 is a C2 alkenyl. In some embodiments, R1 is a C3 alkenyl. In some embodiments, R1 is a C4 alkenyl. In some embodiments, R1 is a C5 alkenyl. In some embodiments, R1 is a C6 alkenyl.

[0100] In some embodiments, R1 is C 2~6 It is an alkynyl. In some embodiments, R1 is a C2 alkynyl. In some embodiments, R1 is a C3 alkynyl. In some embodiments, R1 is a C4 alkynyl. In some embodiments, R1 is a C5 alkynyl. In some embodiments, R1 is a C6 alkynyl.

[0101] In some embodiments, each R1 is H or C 1~6 It is alkyl.

[0102] In some embodiments, R4 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0103] In some embodiments, R4 is H.

[0104] In some embodiments, R4 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0105] In some embodiments, R4 is C 1~6 It is alkyl. In some embodiments, R4 is methyl. In some embodiments, R4 is ethyl. In some embodiments, R4 is propyl. In some embodiments, R4 is butyl. In some embodiments, R4 is pentyl. In some embodiments, R4 is hexyl. In some embodiments, R4 is isopropyl. In some embodiments, R4 is isobutyl. In some embodiments, R4 is isopentyl. In some embodiments, R4 is isohexyl. In some embodiments, R4 is sec-butyl. In some embodiments, R4 is sec-pentyl. In some embodiments, R4 is sec-hexyl. In some embodiments, R4 is tert-butyl.

[0106] In some embodiments, R4 is C 2~6 It is an alkenyl. In some embodiments, R4 is a C2 alkenyl. In some embodiments, R4 is a C3 alkenyl. In some embodiments, R4 is a C4 alkenyl. In some embodiments, R4 is a C5 alkenyl. In some embodiments, R4 is a C6 alkenyl.

[0107] In some embodiments, R4 is C 2~6 It is an alkynyl. In some embodiments, R4 is a C2 alkynyl. In some embodiments, R4 is a C3 alkynyl. In some embodiments, R4 is a C4 alkynyl. In some embodiments, R4 is a C5 alkynyl. In some embodiments, R4 is a C6 alkynyl.

[0108] In some embodiments, each R4 is H or C 1~6 It is alkyl.

[0109] In some embodiments, R2 and R3 are independently H, C2~6 Alkenyl, C 2~6 Alkynyl, -O-C 1~6 Alkyl, -O-C 2~6 Alkenyl, -O-C 2~6 Alkynyl, -C(O)R 11 , -C(O)OR 11 , -C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 , -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and where neither R2 nor R3 is H.

[0110] In some embodiments, R2 and R3 are each independently, C 2~6 Alkenyl, C 2~6 Alkynyl, -O-C 1~6 Alkyl, -O-C 2~6 Alkenyl, -O-C 2~6 Alkynyl, -C(O)R 11 , -C(O)OR 11 , -C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 , -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0111] In some embodiments, R2 and R3 are each independently, -O-C 1~6 Alkyl, -C(O)R 11 , -C(O)OR 11 , -C(O)N(R 11 )2, or -C(O)NR 11 -S(O)2R 11 .

[0112] In some embodiments, either R2 or R3 is not H.

[0113] In some embodiments, R2 is not H.

[0114] In some embodiments, R3 is not H.

[0115] In some embodiments, R2 is H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0116] In some embodiments, R2 is H.

[0117] In some embodiments, R2 is C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0118] In some embodiments, R2 is C 2~6 Alkenyl or C 2~6 It is alkinyl.

[0119] In some embodiments, R2 is C 2~6 It is an alkenyl. In some embodiments, R2 is a C2 alkenyl. In some embodiments, R2 is a C3 alkenyl. In some embodiments, R2 is a C4 alkenyl. In some embodiments, R2 is a C5 alkenyl. In some embodiments, R2 is a C6 alkenyl.

[0120] In some embodiments, R2 is C 2~6 It is an alkynyl. In some embodiments, R2 is a C2 alkynyl. In some embodiments, R2 is a C3 alkynyl. In some embodiments, R2 is a C4 alkynyl. In some embodiments, R2 is a C5 alkynyl. In some embodiments, R2 is a C6 alkynyl.

[0121] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0122] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is alkinyl.

[0123] In some embodiments, R2 is -OC 1~6It is alkyl. In some embodiments, R2 is -O-methyl. In some embodiments, R2 is -O-ethyl. In some embodiments, R2 is -O-propyl. In some embodiments, R2 is -O-butyl. In some embodiments, R2 is -O-pentyl. In some embodiments, R2 is -O-hexyl. In some embodiments, R2 is -O-isopropyl. In some embodiments, R2 is -O-isobutyl. In some embodiments, R2 is -O-isopentyl. In some embodiments, R2 is -O-isohexyl. In some embodiments, R2 is -O-secbutyl. In some embodiments, R2 is -O-secpentyl. In some embodiments, R2 is -O-sechexyl. In some embodiments, R2 is -O-tertbutyl.

[0124] In some embodiments, R2 is -OC 2~6 It is an alkenyl. In some embodiments, R2 is an -O-C2 alkenyl. In some embodiments, R2 is an -O-C3 alkenyl. In some embodiments, R2 is an -O-C4 alkenyl. In some embodiments, R2 is an -O-C5 alkenyl. In some embodiments, R2 is an -O-C6 alkenyl.

[0125] In some embodiments, R2 is -OC 2~6 It is an alkynyl. In some embodiments, R2 is an -O-C2 alkynyl. In some embodiments, R2 is an -O-C3 alkynyl. In some embodiments, R2 is an -O-C4 alkynyl. In some embodiments, R2 is an -O-C5 alkynyl. In some embodiments, R2 is an -O-C6 alkynyl.

[0126] In some embodiments, R2 is -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR11 -S(O)2-N(R 11 )2.

[0127] In some embodiments, R2 is -C(O)R 11 , -C(O)OR 11 , or -C(O)N(R 11 )2.

[0128] In some embodiments, R2 is -C(O)R 11 In some embodiments, R2 is -C(O)OR 11 In some embodiments, R2 is -C(O)N(R 11 )2.

[0129] In some embodiments, R2 is -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0130] In some embodiments, R2 is -C(O)NR 11 -S(O)2R 11 In some embodiments, R2 is -C(O)NR 11 -S(O)2-OR 11 In some embodiments, R2 is -C(O)NR 11 -S(O)2-N(R 11 )2.

[0131] In some embodiments, R2 is -OC 1~6 Alkyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, or -C(O)NR 11 -S(O)2R 11 That is the case.

[0132] In some embodiments, R3 is H, C 2~6 Alkenil, C 2~6Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0133] In some embodiments, R3 is H.

[0134] In some embodiments, R3 is C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0135] In some embodiments, R3 is C 2~6 Alkenyl or C 2~6 It is alkinyl.

[0136] In some embodiments, R3 is C 2~6 It is an alkenyl. In some embodiments, R3 is a C2 alkenyl. In some embodiments, R3 is a C3 alkenyl. In some embodiments, R3 is a C4 alkenyl. In some embodiments, R3 is a C5 alkenyl. In some embodiments, R3 is a C6 alkenyl.

[0137] In some embodiments, R3 is C 2~6 It is an alkynyl. In some embodiments, R3 is a C2 alkynyl. In some embodiments, R3 is a C3 alkynyl. In some embodiments, R3 is a C4 alkynyl. In some embodiments, R3 is a C5 alkynyl. In some embodiments, R3 is a C6 alkynyl.

[0138] In some embodiments, R3 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0139] In some embodiments, R3 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is alkinyl.

[0140] In some embodiments, R3 is -OC 1~6It is alkyl. In some embodiments, R3 is -O-methyl. In some embodiments, R3 is -O-ethyl. In some embodiments, R3 is -O-propyl. In some embodiments, R3 is -O-butyl. In some embodiments, R3 is -O-pentyl. In some embodiments, R3 is -O-hexyl. In some embodiments, R3 is -O-isopropyl. In some embodiments, R3 is -O-isobutyl. In some embodiments, R3 is -O-isopentyl. In some embodiments, R3 is -O-isohexyl. In some embodiments, R3 is -O-secbutyl. In some embodiments, R3 is -O-secpentyl. In some embodiments, R3 is -O-sechexyl. In some embodiments, R3 is -O-tertbutyl.

[0141] In some embodiments, R3 is -OC 2~6 It is an alkenyl. In some embodiments, R3 is an -O-C2 alkenyl. In some embodiments, R3 is an -O-C3 alkenyl. In some embodiments, R3 is an -O-C4 alkenyl. In some embodiments, R3 is an -O-C5 alkenyl. In some embodiments, R3 is an -O-C6 alkenyl.

[0142] In some embodiments, R3 is -OC 2~6 It is an alkynyl. In some embodiments, R3 is an -O-C2 alkynyl. In some embodiments, R3 is an -O-C3 alkynyl. In some embodiments, R3 is an -O-C4 alkynyl. In some embodiments, R3 is an -O-C5 alkynyl. In some embodiments, R3 is an -O-C6 alkynyl.

[0143] In some embodiments, R3 is -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR11 -S(O)2-N(R 11 )2.

[0144] In some embodiments, R3 is -C(O)R 11 , -C(O)OR 11 , or -C(O)N(R 11 )2.

[0145] In some embodiments, R3 is -C(O)R 11 In some embodiments, R3 is -C(O)OR 11 In some embodiments, R3 is -C(O)N(R 11 )2.

[0146] In some embodiments, R3 is -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0147] In some embodiments, R3 is -C(O)NR 11 -S(O)2R 11 In some embodiments, R3 is -C(O)NR 11 -S(O)2-OR 11 In some embodiments, R3 is -C(O)NR 11 -S(O)2-N(R 11 )2.

[0148] In some embodiments, R3 is -OC 1~6 Alkyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, or -C(O)NR 11 -S(O)2R 11 That is the case.

[0149] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl may be substituted with one or more R7s.

[0150] In some embodiments, R5 and R6 are independent of each other, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl may be substituted with one or more R7s.

[0151] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0152] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0153] In some embodiments, R5 and R6 are H independently.

[0154] In some embodiments, R5 and R6 are independent of each other, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0155] In some embodiments, R5 and R6 are independent of each other, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0156] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5- to 13-membered heteroaryl or -C(O)R7 containing 1 to 4 heteroatoms selected from aryl, N, O, and S, where the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0157] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0158] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5- to 13-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with one or more R7 atoms.

[0159] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl is substituted with one or more R7s.

[0160] In some embodiments, R5 is H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0161] In some embodiments, R5 is H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0162] In some embodiments, R5 is H.

[0163] In some embodiments, R5 is C1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0164] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0165] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 The alkyl, alkenyl, or alkynyl is substituted with one or more R7 groups.

[0166] In some embodiments, R5 may be replaced by one or more R7s. 1~6It is alkyl. In some embodiments, R5 is methyl, which may be substituted with one or more R7s. In some embodiments, R5 is ethyl, which may be substituted with one or more R7s. In some embodiments, R5 is propyl, which may be substituted with one or more R7s. In some embodiments, R5 is butyl, which may be substituted with one or more R7s. In some embodiments, R5 is pentyl, which may be substituted with one or more R7s. In some embodiments, R5 is hexyl, which may be substituted with one or more R7s. In some embodiments, R5 is isopropyl, which may be substituted with one or more R7s. In some embodiments, R5 is isobutyl, which may be substituted with one or more R7s. In some embodiments, R5 is isopentyl, which may be substituted with one or more R7s. In some embodiments, R5 is isohexyl, which may be substituted with one or more R7s. In some embodiments, R5 is secbutyl, which may be substituted with one or more R7s. In some embodiments, R5 is sec-pentyl which may be substituted with one or more R7 atoms. In some embodiments, R5 is sec-hexyl which may be substituted with one or more R7 atoms. In some embodiments, R5 is tert-butyl which may be substituted with one or more R7 atoms.

[0167] In some embodiments, R5 may be replaced by one or more R7s. 2~6 It is an alkenyl. In some embodiments, R5 is a C2 alkenyl which may be substituted with one or more R7s. In some embodiments, R5 is a C3 alkenyl which may be substituted with one or more R7s. In some embodiments, R5 is a C4 alkenyl which may be substituted with one or more R7s. In some embodiments, R5 is a C5 alkenyl which may be substituted with one or more R7s. In some embodiments, R5 is a C6 alkenyl which may be substituted with one or more R7s.

[0168] In some embodiments, R5 may be replaced by one or more R7s. 2~6 It is an alkynyl. In some embodiments, R5 is a C2 alkynyl which may be substituted with one or more R7s. In some embodiments, R5 is a C3 alkynyl which may be substituted with one or more R7s. In some embodiments, R5 is a C4 alkynyl which may be substituted with one or more R7s. In some embodiments, R5 is a C5 alkynyl which may be substituted with one or more R7s. In some embodiments, R5 is a C6 alkynyl which may be substituted with one or more R7s.

[0169] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 The alkyl, alkenyl, or alkynyl is substituted with one or more R7 groups.

[0170] In some embodiments, R5 is replaced by one or more R7s. 1~6It is alkyl. In some embodiments, R5 is methyl substituted with one or more R7s. In some embodiments, R5 is ethyl substituted with one or more R7s. In some embodiments, R5 is propyl substituted with one or more R7s. In some embodiments, R5 is butyl substituted with one or more R7s. In some embodiments, R5 is pentyl substituted with one or more R7s. In some embodiments, R5 is hexyl substituted with one or more R7s. In some embodiments, R5 is isopropyl substituted with one or more R7s. In some embodiments, R5 is isobutyl substituted with one or more R7s. In some embodiments, R5 is isopentyl substituted with one or more R7s. In some embodiments, R5 is isohexyl substituted with one or more R7s. In some embodiments, R5 is secbutyl substituted with one or more R7s. In some embodiments, R5 is sec-pentyl substituted with one or more R7 atoms. In some embodiments, R5 is sec-hexyl substituted with one or more R7 atoms. In some embodiments, R5 is tert-butyl substituted with one or more R7 atoms.

[0171] In some embodiments, R5 is replaced by one or more R7s. 2~6 It is an alkenyl. In some embodiments, R5 is a C2 alkenyl substituted with one or more R7s. In some embodiments, R5 is a C3 alkenyl substituted with one or more R7s. In some embodiments, R5 is a C4 alkenyl substituted with one or more R7s. In some embodiments, R5 is a C5 alkenyl substituted with one or more R7s. In some embodiments, R5 is a C6 alkenyl substituted with one or more R7s.

[0172] In some embodiments, R5 is replaced by one or more R7s. 2~6It is an alkynyl. In some embodiments, R5 is a C2 alkynyl substituted with one or more R7s. In some embodiments, R5 is a C3 alkynyl substituted with one or more R7s. In some embodiments, R5 is a C4 alkynyl substituted with one or more R7s. In some embodiments, R5 is a C5 alkynyl substituted with one or more R7s. In some embodiments, R5 is a C6 alkynyl substituted with one or more R7s.

[0173] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is substituted with one R7.

[0174] In some embodiments, R5 is replaced by a single R7. 1~6 It is alkyl. In some embodiments, R5 is methyl substituted with one R7. In some embodiments, R5 is ethyl substituted with one R7. In some embodiments, R5 is propyl substituted with one R7. In some embodiments, R5 is butyl substituted with one R7. In some embodiments, R5 is pentyl substituted with one R7. In some embodiments, R5 is hexyl substituted with one R7. In some embodiments, R5 is isopropyl substituted with one R7. In some embodiments, R5 is isobutyl substituted with one R7. In some embodiments, R5 is isopentyl substituted with one R7. In some embodiments, R5 is isohexyl substituted with one R7. In some embodiments, R5 is secbutyl substituted with one R7. In some embodiments, R5 is secpentyl substituted with one R7. In some embodiments, R5 is sec-hexyl substituted with one R7. In some embodiments, R5 is tert-butyl substituted with one R7.

[0175] In some embodiments, R5 is replaced by a single R7.2~6 It is an alkenyl. In some embodiments, R5 is a C2 alkenyl substituted with one R7. In some embodiments, R5 is a C3 alkenyl substituted with one R7. In some embodiments, R5 is a C4 alkenyl substituted with one R7. In some embodiments, R5 is a C5 alkenyl substituted with one R7. In some embodiments, R5 is a C6 alkenyl substituted with one R7.

[0176] In some embodiments, R5 is replaced by a single R7. 2~6 It is an alkynyl. In some embodiments, R5 is a C2 alkynyl substituted with one R7. In some embodiments, R5 is a C3 alkynyl substituted with one R7. In some embodiments, R5 is a C4 alkynyl substituted with one R7. In some embodiments, R5 is a C5 alkynyl substituted with one R7. In some embodiments, R5 is a C6 alkynyl substituted with one R7.

[0177] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0178] In some embodiments, R5 is C 1~6 It is alkyl. In some embodiments, R5 is methyl. In some embodiments, R5 is ethyl. In some embodiments, R5 is propyl. In some embodiments, R5 is butyl. In some embodiments, R5 is pentyl. In some embodiments, R5 is hexyl. In some embodiments, R5 is isopropyl. In some embodiments, R5 is isobutyl. In some embodiments, R5 is isopentyl. In some embodiments, R5 is isohexyl. In some embodiments, R5 is sec-butyl. In some embodiments, R5 is sec-pentyl. In some embodiments, R5 is sec-hexyl. In some embodiments, R5 is tert-butyl.

[0179] In some embodiments, R5 is C 2~6 It is an alkenyl. In some embodiments, R5 is a C2 alkenyl. In some embodiments, R5 is a C3 alkenyl. In some embodiments, R5 is a C4 alkenyl. In some embodiments, R5 is a C5 alkenyl. In some embodiments, R5 is a C6 alkenyl.

[0180] In some embodiments, R5 is C 2~6 It is an alkynyl. In some embodiments, R5 is a C2 alkynyl. In some embodiments, R5 is a C3 alkynyl. In some embodiments, R5 is a C4 alkynyl. In some embodiments, R5 is a C5 alkynyl. In some embodiments, R5 is a C6 alkynyl.

[0181] In some embodiments, R5 is C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0182] In some embodiments, R5 is C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0183] In some embodiments, R5 is C 3~10 A cycloalkyl or a 3-13 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline may be substituted with one or more R7 atoms.

[0184] In some embodiments, R5 is C 3~10 It is a cycloalkyl or a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0185] In some embodiments, R5 may be replaced by one or more R7s. 3~10 It is a cycloalkyl group.

[0186] In some embodiments, R5 is a C3 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C4 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C5 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C6 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C7 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C8 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C9 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C 10 It is a cycloalkyl group.

[0187] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R5 is a C9-C7 monocyclic cycloalkyl group which may be substituted with one or more R7 groups. 10 It is a bicyclic cycloalkyl group. In some embodiments, R5 may be substituted with one or more R7s C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R5 may be substituted with one or more R7s C9-C10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R5 may be substituted with one or more R7s C8~C 10 It is a polycyclic cycloalkyl compound.

[0188] In some embodiments, R5 is replaced by one or more R7s. 3~10 It is a cycloalkyl group.

[0189] In some embodiments, R5 is a C3 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C4 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C5 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C6 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C7 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C8 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C9 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C6 cycloalkyl group substituted with one or more R7 groups. 10 It is a cycloalkyl group.

[0190] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C9-C7 monocyclic cycloalkyl group substituted with one or more R7 groups. 10 It is a bicyclic cycloalkyl. In some embodiments, R5 is substituted with one or more R7s, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R5 is substituted with one or more R7s, C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R5 is a C8-C substituted with one or more R7s.10 It is a polycyclic cycloalkyl compound.

[0191] In some embodiments, R5 is replaced by a single R7. 3~10 It is a cycloalkyl group.

[0192] In some embodiments, R5 is a C3 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C4 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C5 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C6 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C7 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C8 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C9 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C6 cycloalkyl group substituted with one R7. 10 It is a cycloalkyl group.

[0193] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group substituted with one R7. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one R7. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one R7. In some embodiments, R5 is a C9-C7 monocyclic partially saturated cycloalkyl group substituted with one R7. 10 It is a bicyclic cycloalkyl group. In some embodiments, R5 is substituted with one R7, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R5 is substituted with one R7, C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R5 is a C8-C substituted with one R7. 10 It is a polycyclic cycloalkyl compound.

[0194] In some embodiments, R5 is C 3~10 It is a cycloalkyl group.

[0195] In some embodiments, R5 is a C3 cycloalkyl group. In some embodiments, R5 is a C4 cycloalkyl group. In some embodiments, R5 is a C5 cycloalkyl group. In some embodiments, R5 is a C6 cycloalkyl group. In some embodiments, R5 is a C7 cycloalkyl group. In some embodiments, R5 is a C8 cycloalkyl group. In some embodiments, R5 is a C9 cycloalkyl group. In some embodiments, R5 is a C 10 It is a cycloalkyl group.

[0196] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group. In some embodiments, R5 is a C9-C 10 It is a bicyclic cycloalkyl. In some embodiments, R5 is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R5 is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R5 is C8~C 10 It is a polycyclic cycloalkyl compound.

[0197] In some embodiments, R5 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0198] In some embodiments, R5 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0199] In some embodiments, R5 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0200] In some embodiments, R5 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0201] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0202] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0203] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0204] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0205] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heterocycline comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0206] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with one or more R7s.

[0207] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0208] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0209] In some embodiments, R5 is C 6~10 A 5-13 member heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl may be substituted with one or more R7 atoms.

[0210] In some embodiments, R5 is C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0211] In some embodiments, R5 may be replaced by one or more R7s. 6~10 It is Ariel.

[0212] In some embodiments, R5 may be replaced by one or more R7s. 6~8 It is an aryl compound. In some embodiments, R5 is a phenyl compound which may be substituted with one or more R7s.

[0213] In some embodiments, R5 is replaced by one or more R7s. 6~8 It is an aryl compound. In some embodiments, R5 is a phenyl compound substituted with one or more R7s.

[0214] In some embodiments, R5 is replaced by a single R7. 6~8 It is an aryl compound. In some embodiments, R5 is a phenyl compound substituted with one R7.

[0215] In some embodiments, R5 is C 6~10 It is Ariel.

[0216] In some embodiments, R5 is C 6~8 It is an aryl compound. In some embodiments, R5 is a phenyl compound.

[0217] In some embodiments, R5 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0218] In some embodiments, R5 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0219] In some embodiments, R5 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0220] In some embodiments, R5 is a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 5-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 6-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 7-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0221] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0222] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered bicyclic heteroaryl substituted with one or more R7s, comprising 1 to 4 heteroatoms selected from N, O, and S.

[0223] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered bicyclic heteroaryl substituted with one R7, containing 1 to 4 heteroatoms selected from N, O, and S.

[0224] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0225] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0226] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which are substituted with one or more R7 atoms.

[0227] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0228] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0229] In some embodiments, R5 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5- to 13-membered heteroaryl or -C(O)R7 containing 1 to 4 heteroatoms selected from aryl, N, O, and S, where the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0230] In some embodiments, R5 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0231] In some embodiments, R5 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5- to 13-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with one or more R7 atoms.

[0232] In some embodiments, R5 is cyclopropyl, piperidine, tetrahydropyran, morpholine, phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0233] In some embodiments, R5 is cyclopropyl, piperidine, tetrahydropyran, or morpholine.

[0234] In some embodiments, R5 is phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0235] In some embodiments, R5 is pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0236] In some embodiments, R5 is a pyridine or pyrimidine.

[0237] In some embodiments, R5 is tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0238] In some embodiments, R5 is a tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, or imidazole.

[0239] In some embodiments, R5 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0240] In some embodiments, R5 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, or benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole.

[0241] In some embodiments, R5 is 9H-carbazole.

[0242] In some embodiments, R6 is H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0243] In some embodiments, R6 is H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0244] In some embodiments, R6 is H.

[0245] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0246] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0247] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 The alkyl, alkenyl, or alkynyl is substituted with one or more R7 groups.

[0248] In some embodiments, R6 may be replaced by one or more R7s. 1~6It is alkyl. In some embodiments, R6 is methyl which may be substituted with one or more R7s. In some embodiments, R6 is ethyl which may be substituted with one or more R7s. In some embodiments, R6 is propyl which may be substituted with one or more R7s. In some embodiments, R6 is butyl which may be substituted with one or more R7s. In some embodiments, R6 is pentyl which may be substituted with one or more R7s. In some embodiments, R6 is hexyl which may be substituted with one or more R7s. In some embodiments, R6 is isopropyl which may be substituted with one or more R7s. In some embodiments, R6 is isobutyl which may be substituted with one or more R7s. In some embodiments, R6 is isopentyl which may be substituted with one or more R7s. In some embodiments, R6 is isohexyl which may be substituted with one or more R7s. In some embodiments, R6 is secbutyl which may be substituted with one or more R7s. In some embodiments, R6 is sec-pentyl which may be substituted with one or more R7 atoms. In some embodiments, R6 is sec-hexyl which may be substituted with one or more R7 atoms. In some embodiments, R6 is tert-butyl which may be substituted with one or more R7 atoms.

[0249] In some embodiments, R6 may be replaced by one or more R7s. 2~6 It is an alkenyl. In some embodiments, R6 is a C2 alkenyl which may be substituted with one or more R7s. In some embodiments, R6 is a C3 alkenyl which may be substituted with one or more R7s. In some embodiments, R6 is a C4 alkenyl which may be substituted with one or more R7s. In some embodiments, R6 is a C5 alkenyl which may be substituted with one or more R7s. In some embodiments, R6 is a C6 alkenyl which may be substituted with one or more R7s.

[0250] In some embodiments, R6 may be replaced by one or more R7s. 2~6 It is an alkynyl. In some embodiments, R6 is a C2 alkynyl which may be substituted with one or more R7s. In some embodiments, R6 is a C3 alkynyl which may be substituted with one or more R7s. In some embodiments, R6 is a C4 alkynyl which may be substituted with one or more R7s. In some embodiments, R6 is a C5 alkynyl which may be substituted with one or more R7s. In some embodiments, R6 is a C6 alkynyl which may be substituted with one or more R7s.

[0251] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 The alkyl, alkenyl, or alkynyl is substituted with one or more R7 groups.

[0252] In some embodiments, R6 is replaced by one or more R7s. 1~6It is alkyl. In some embodiments, R6 is methyl substituted with one or more R7s. In some embodiments, R6 is ethyl substituted with one or more R7s. In some embodiments, R6 is propyl substituted with one or more R7s. In some embodiments, R6 is butyl substituted with one or more R7s. In some embodiments, R6 is pentyl substituted with one or more R7s. In some embodiments, R6 is hexyl substituted with one or more R7s. In some embodiments, R6 is isopropyl substituted with one or more R7s. In some embodiments, R6 is isobutyl substituted with one or more R7s. In some embodiments, R6 is isopentyl substituted with one or more R7s. In some embodiments, R6 is isohexyl substituted with one or more R7s. In some embodiments, R6 is secbutyl substituted with one or more R7s. In some embodiments, R6 is sec-pentyl substituted with one or more R7 atoms. In some embodiments, R6 is sec-hexyl substituted with one or more R7 atoms. In some embodiments, R6 is tert-butyl substituted with one or more R7 atoms.

[0253] In some embodiments, R6 is replaced by one or more R7s. 2~6 It is an alkenyl. In some embodiments, R6 is a C2 alkenyl substituted with one or more R7s. In some embodiments, R6 is a C3 alkenyl substituted with one or more R7s. In some embodiments, R6 is a C4 alkenyl substituted with one or more R7s. In some embodiments, R6 is a C5 alkenyl substituted with one or more R7s. In some embodiments, R6 is a C6 alkenyl substituted with one or more R7s.

[0254] In some embodiments, R6 is replaced by one or more R7s. 2~6It is an alkynyl. In some embodiments, R6 is a C2 alkynyl substituted with one or more R7s. In some embodiments, R6 is a C3 alkynyl substituted with one or more R7s. In some embodiments, R6 is a C4 alkynyl substituted with one or more R7s. In some embodiments, R6 is a C5 alkynyl substituted with one or more R7s. In some embodiments, R6 is a C6 alkynyl substituted with one or more R7s.

[0255] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is substituted with one R7.

[0256] In some embodiments, R6 is replaced by a single R7. 1~6 It is alkyl. In some embodiments, R6 is methyl substituted with one R7. In some embodiments, R6 is ethyl substituted with one R7. In some embodiments, R6 is propyl substituted with one R7. In some embodiments, R6 is butyl substituted with one R7. In some embodiments, R6 is pentyl substituted with one R7. In some embodiments, R6 is hexyl substituted with one R7. In some embodiments, R6 is isopropyl substituted with one R7. In some embodiments, R6 is isobutyl substituted with one R7. In some embodiments, R6 is isopentyl substituted with one R7. In some embodiments, R6 is isohexyl substituted with one R7. In some embodiments, R6 is secbutyl substituted with one R7. In some embodiments, R6 is secpentyl substituted with one R7. In some embodiments, R6 is sec hexyl substituted with one R7. In some embodiments, R6 is tert butyl substituted with one R7.

[0257] In some embodiments, R6 is replaced by a single R7.2~6 It is an alkenyl. In some embodiments, R6 is a C2 alkenyl substituted with one R7. In some embodiments, R6 is a C3 alkenyl substituted with one R7. In some embodiments, R6 is a C4 alkenyl substituted with one R7. In some embodiments, R6 is a C5 alkenyl substituted with one R7. In some embodiments, R6 is a C6 alkenyl substituted with one R7.

[0258] In some embodiments, R6 is replaced by a single R7. 2~6 It is an alkynyl. In some embodiments, R6 is a C2 alkynyl substituted with one R7. In some embodiments, R6 is a C3 alkynyl substituted with one R7. In some embodiments, R6 is a C4 alkynyl substituted with one R7. In some embodiments, R6 is a C5 alkynyl substituted with one R7. In some embodiments, R6 is a C6 alkynyl substituted with one R7.

[0259] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0260] In some embodiments, R6 is C 1~6 It is alkyl. In some embodiments, R6 is methyl. In some embodiments, R6 is ethyl. In some embodiments, R6 is propyl. In some embodiments, R6 is butyl. In some embodiments, R6 is pentyl. In some embodiments, R6 is hexyl. In some embodiments, R6 is isopropyl. In some embodiments, R6 is isobutyl. In some embodiments, R6 is isopentyl. In some embodiments, R6 is isohexyl. In some embodiments, R6 is sec-butyl. In some embodiments, R6 is sec-pentyl. In some embodiments, R6 is sec-hexyl. In some embodiments, R6 is tert-butyl.

[0261] In some embodiments, R6 is C 2~6 It is an alkenyl. In some embodiments, R6 is a C2 alkenyl. In some embodiments, R6 is a C3 alkenyl. In some embodiments, R6 is a C4 alkenyl. In some embodiments, R6 is a C5 alkenyl. In some embodiments, R6 is a C6 alkenyl.

[0262] In some embodiments, R6 is C 2~6 It is an alkynyl. In some embodiments, R6 is a C2 alkynyl. In some embodiments, R6 is a C3 alkynyl. In some embodiments, R6 is a C4 alkynyl. In some embodiments, R6 is a C5 alkynyl. In some embodiments, R6 is a C6 alkynyl.

[0263] In some embodiments, R6 is C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0264] In some embodiments, R6 is C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0265] In some embodiments, R6 is C 3~10 A cycloalkyl or a 3-13 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline may be substituted with one or more R7 atoms.

[0266] In some embodiments, R6 is C 3~10 It is a cycloalkyl or a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0267] In some embodiments, R6 may be replaced by one or more R7s. 3~10 It is a cycloalkyl group.

[0268] In some embodiments, R6 is a C3 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C4 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C5 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C6 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C7 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C8 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C9 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C 10 It is a cycloalkyl group.

[0269] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R6 is a C9-C7 monocyclic cycloalkyl group which may be substituted with one or more R7 groups. 10 It is a bicyclic cycloalkyl group. In some embodiments, R6 may be substituted with one or more R7s C9-C 10 It is a bicyclic saturated cycloalkyl group. In some embodiments, R6 may be substituted with one or more R7s C9-C10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R6 may be substituted with one or more R7s C8-C 10 It is a polycyclic cycloalkyl compound.

[0270] In some embodiments, R6 is replaced by one or more R7s. 3~10 It is a cycloalkyl group.

[0271] In some embodiments, R6 is a C3 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C4 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C5 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C6 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C7 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C8 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C9 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C 10 It is a cycloalkyl group.

[0272] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C9-C7 monocyclic cycloalkyl group substituted with one or more R7 groups. 10 It is a bicyclic cycloalkyl. In some embodiments, R6 is substituted with one or more R7s, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R6 is substituted with one or more R7s, C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R6 is a C8-C substituted with one or more R7s.10 It is a polycyclic cycloalkyl compound.

[0273] In some embodiments, R6 is replaced by a single R7. 3~10 It is a cycloalkyl group.

[0274] In some embodiments, R6 is a C3 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C4 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C5 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C6 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C7 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C8 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C9 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C 10 It is a cycloalkyl group.

[0275] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group substituted with one R7. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one R7. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one R7. In some embodiments, R6 is a C9-C7 monocyclic partially saturated cycloalkyl group substituted with one R7. 10 It is a bicyclic cycloalkyl group. In some embodiments, R6 is substituted with one R7, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R6 is substituted with one R7, C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R6 is a C8-C substituted with one R7. 10 It is a polycyclic cycloalkyl compound.

[0276] In some embodiments, R6 is C 3~10 It is a cycloalkyl group.

[0277] In some embodiments, R6 is a C3 cycloalkyl group. In some embodiments, R6 is a C4 cycloalkyl group. In some embodiments, R6 is a C5 cycloalkyl group. In some embodiments, R6 is a C6 cycloalkyl group. In some embodiments, R6 is a C7 cycloalkyl group. In some embodiments, R6 is a C8 cycloalkyl group. In some embodiments, R6 is a C9 cycloalkyl group. In some embodiments, R6 is a C 10 It is a cycloalkyl group.

[0278] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl. In some embodiments, R6 is a C9-C 10 It is a bicyclic cycloalkyl. In some embodiments, R6 is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R6 is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R6 is C8~C 10 It is a polycyclic cycloalkyl compound.

[0279] In some embodiments, R6 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0280] In some embodiments, R6 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0281] In some embodiments, R6 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0282] In some embodiments, R6 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0283] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0284] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0285] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0286] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0287] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0288] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with one or more R7s.

[0289] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0290] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0291] In some embodiments, R6 is C 6~10 A 5-13 member heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl may be substituted with one or more R7 atoms.

[0292] In some embodiments, R6 is C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0293] In some embodiments, R6 may be replaced by one or more R7s. 6~10 It is Ariel.

[0294] In some embodiments, R6 may be replaced by one or more R7s. 6~8 It is an aryl compound. In some embodiments, R6 is a phenyl compound which may be substituted with one or more R7s.

[0295] In some embodiments, R6 is replaced by one or more R7s. 6~8 It is an aryl compound. In some embodiments, R6 is a phenyl compound substituted with one or more R7s.

[0296] In some embodiments, R6 is replaced by a single R7. 6~8 It is an aryl compound. In some embodiments, R6 is a phenyl compound substituted with one R7.

[0297] In some embodiments, R6 is C 6~10 It is Ariel.

[0298] In some embodiments, R6 is C 6~8 It is an aryl compound. In some embodiments, R6 is a phenyl compound.

[0299] In some embodiments, R6 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0300] In some embodiments, R6 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0301] In some embodiments, R6 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0302] In some embodiments, R6 is a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 5-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 6-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 7-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0303] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0304] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0305] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered bicyclic heteroaryl substituted with one R7, containing 1 to 4 heteroatoms selected from N, O, and S.

[0306] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0307] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0308] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0309] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0310] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0311] In some embodiments, R6 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5- to 13-membered heteroaryl or -C(O)R7 containing 1 to 4 heteroatoms selected from aryl, N, O, and S, where the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0312] In some embodiments, R6 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0313] In some embodiments, R6 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5- to 13-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with one or more R7 atoms.

[0314] In some embodiments, R6 is cyclopropyl, piperidine, tetrahydropyran, morpholine, phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0315] In some embodiments, R6 is cyclopropyl, piperidine, tetrahydropyran, or morpholine.

[0316] In some embodiments, R6 is phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0317] In some embodiments, R6 is pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0318] In some embodiments, R6 is a pyridine or pyrimidine.

[0319] In some embodiments, R6 is tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0320] In some embodiments, R6 is a tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, or imidazole.

[0321] In some embodiments, R6 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0322] In some embodiments, R6 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, or benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole.

[0323] In some embodiments, R6 is 9H-carbazole.

[0324] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl may be substituted with one or more R7s.

[0325] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0326] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0327] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a four-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0328] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0329] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0330] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0331] In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0332] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a nine-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0333] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0334] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which are substituted with one or more R7 atoms.

[0335] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a four-membered heterocycline containing one to four heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heterocycline containing one to four heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0336] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which are substituted with one R7.

[0337] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a four-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an eight-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7.

[0338] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0339] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a four-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an eight-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a nine-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0340] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5-10 membered heteroaryl comprising 1-4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0341] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a seven-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an eight-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a nine-membered heteroaryl compound containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a ten-membered heteroaryl compound containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0342] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 5-10 membered heteroaryl ion comprising 1-4 heteroatoms selected from N, O, and S, which are substituted with one or more R7 atoms.

[0343] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 10-membered heteroaryl ion comprising 1 to 4 heteroatoms selected from N, O, and S, which are substituted with one or more R7 atoms.

[0344] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a nine-membered heteroaryl compound containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a ten-membered heteroaryl compound containing one to four heteroatoms selected from N, O, and S, each substituted with one R7.

[0345] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 5-10 membered heteroaryl aryl composing 1-4 heteroatoms selected from N, O, and S.

[0346] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0347] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a piperidine which may be substituted with one or more R7 atoms.

[0348] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a piperidine substituted with one or more R7 atoms.

[0349] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a piperidine substituted with one R7.

[0350] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a piperidine.

[0351] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroquinoline which may be substituted with one or more R7 atoms.

[0352] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroquinoline substituted with one or more R7 atoms.

[0353] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroquinoline substituted with one R7.

[0354] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form tetrahydroquinoline.

[0355] In some embodiments, each R7 is independently oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may be replaced with .

[0356] In some embodiments, each R7 is independently oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0357] In some embodiments, R7 is oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2,-O-(CH2) t -R8, or -NH-(CH2) t -R8

[0358] In some embodiments, R7 is an oxo, halogen, -OH, -NH2, or -CN.

[0359] In some embodiments, R7 is an oxo.

[0360] In some embodiments, R7 is a halogen. In some embodiments, R7 is F, Cl, Br, or I. In some embodiments, R7 is F, Cl, or Br. In some embodiments, R7 is F. In some embodiments, R7 is Cl. In some embodiments, R7 is Br. In some embodiments, R7 is I.

[0361] In some embodiments, R7 is -OH. In some embodiments, R7 is -NH2. In some embodiments, R7 is -CN.

[0362] In some embodiments, R7 is -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2,-O-(CH2) t -R8, or -NH-(CH2) t -R8

[0363] In some embodiments, R7 is -C(O)R 10 In some aspects, R7 is -C(O)OR 10 In some embodiments, R7 is -C(O)N(R 10 )2. In some embodiments, R7 is -O-(CH2) t -R8. In some embodiments, R7 is -NH-(CH2) t -R8

[0364] In some embodiments, R7 is C 1~6 Alkoxy, -NH(C 1~6 Alkyl), or -N(C 1~6 It is alkyl(2).

[0365] In some embodiments, R7 is C 1~6 It is an alkoxy. In some embodiments, R7 is methoxy. In some embodiments, R7 is ethoxy. In some embodiments, R7 is propoxy. In some embodiments, R7 is butoxy. In some embodiments, R7 is pentoxy. In some embodiments, R7 is hexoxy. In some embodiments, R7 is isopropoxy. In some embodiments, R7 is isobutoxy. In some embodiments, R7 is isopentoxy. In some embodiments, R7 is isohexoxy. In some embodiments, R7 is secbutoxy. In some embodiments, R7 is secpentoxy. In some embodiments, R7 is sechexoxy. In some embodiments, R7 is tertbutoxy.

[0366] In some embodiments, R7 is -NH(C 1~6 Alkyl) or -N(C 1~6 It is alkyl)2. In some embodiments, R7 is -NH(C 1~6 It is alkyl. In some embodiments, R7 is -N(C 1~6 It is alkyl(2).

[0367] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may be replaced with .

[0368] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0369] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more R 10 It may be replaced with .

[0370] In some embodiments, R7 is one or more R 10Even if replaced by C 1~3 It is alkyl. In some embodiments, R7 is one or more R 10 It is a methyl that may be substituted with. In some embodiments, R7 is one or more R 10 It is ethyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a propyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is an isopropyl that may be substituted with [another compound].

[0371] In some embodiments, R7 is one or more R 10 Even if replaced by C 2~6 It is an alkenil. In some embodiments, R7 is one or more R 10 It is a C2 alkenyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C3 alkenyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C4 alkenyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C5 alkenyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C6 alkenyl which may be substituted with [another compound].

[0372] In some embodiments, R7 is one or more R 10 Even if replaced by C 2~6 It is an alkynyl. In some embodiments, R7 is one or more R 10 It is a C2 alkynyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C3 alkynyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C4 alkynyl which may be substituted with. In some embodiments, R7 is one or more R 10It is a C5 alkynyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C6 alkynyl which may be substituted with [another compound].

[0373] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more R 10 It has been replaced with.

[0374] In some embodiments, R7 is one or more R 10 C replaced by 1~3 It is alkyl. In some embodiments, R7 is one or more R 10 It is a methyl substituted with. In some embodiments, R7 is one or more R 10 It is ethyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a propyl substituted with R7. In some embodiments, R7 is one or more R 10 It is isopropyl substituted with [a specific compound].

[0375] In some embodiments, R7 is one or more R 10 C replaced by 2~6 It is an alkenil. In some embodiments, R7 is one or more R 10 It is a C2 alkenyl substituted with. In some embodiments, R7 is one or more R 10 It is a C3 alkenyl substituted with. In some embodiments, R7 is one or more R 10 It is a C4 alkenyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C5 alkenyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C6 alkenyl substituted with [the specified compound].

[0376] In some embodiments, R7 is one or more R 10C replaced by 2~6 It is an alkynyl. In some embodiments, R7 is one or more R 10 It is a C2 alkynyl substituted with. In some embodiments, R7 is one or more R 10 It is a C3 alkynyl substituted with. In some embodiments, R7 is one or more R 10 It is a C4 alkynyl substituted with. In some embodiments, R7 is one or more R 10 It is a C5 alkynyl substituted with. In some embodiments, R7 is one or more R 10 It is a C6 alkynyl substituted with [the specified compound].

[0377] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one R 10 It has been replaced with.

[0378] In some embodiments, R7 is one R 10 C replaced by 1~3 It is alkyl. In some embodiments, R7 is one R 10 It is a methyl substituted with. In some embodiments, R7 is one R 10 It is ethyl substituted with. In some embodiments, R7 is one R 10 It is a propyl substituted with R. In some embodiments, R7 is one R 10 It is isopropyl substituted with [a specific compound].

[0379] In some embodiments, R7 is one R 10 C replaced by 2~6 It is an alkenil. In some embodiments, R7 is one R 10 It is a C2 alkenyl substituted with. In some embodiments, R7 is one R 10 It is a C3 alkenyl substituted with. In some embodiments, R7 is one R 10 It is a C4 alkenyl substituted with R. In some embodiments, R7 is one R10 It is a C5 alkenyl substituted with. In some embodiments, R7 is one R 10 It is a C6 alkenyl substituted with [the specified compound].

[0380] In some embodiments, R7 is one R 10 C replaced by 2~6 It is an alkynyl. In some embodiments, R7 is one R 10 It is a C2 alkynyl substituted with. In some embodiments, R7 is one R 10 It is a C3 alkynyl substituted with. In some embodiments, R7 is one R 10 It is a C4 alkynyl substituted with. In some embodiments, R7 is one R 10 It is a C5 alkynyl substituted with. In some embodiments, R7 is one R 10 It is a C6 alkynyl substituted with [the specified compound].

[0381] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0382] In some embodiments, R7 is C 1~3 It is alkyl. In some embodiments, R7 is methyl. In some embodiments, R7 is ethyl. In some embodiments, R7 is propyl. In some embodiments, R7 is isopropyl.

[0383] In some embodiments, R7 is C 2~6 It is an alkenyl. In some embodiments, R7 is a C2 alkenyl. In some embodiments, R7 is a C3 alkenyl. In some embodiments, R7 is a C4 alkenyl. In some embodiments, R7 is a C5 alkenyl. In some embodiments, R7 is a C6 alkenyl.

[0384] In some embodiments, R7 is C 2~6It is an alkynyl. In some embodiments, R7 is a C2 alkynyl. In some embodiments, R7 is a C3 alkynyl. In some embodiments, R7 is a C4 alkynyl. In some embodiments, R7 is a C5 alkynyl. In some embodiments, R7 is a C6 alkynyl.

[0385] In some embodiments, R7 is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl containing an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may be replaced with .

[0386] In some embodiments, R7 is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0387] In some embodiments, R7 is C 3~10 A cycloalkyl or a 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline contains 1 or more R 10 It may be replaced with .

[0388] In some embodiments, R7 is C 3~10 It is a cycloalkyl or a 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0389] In some embodiments, R7 is one or more R 10 Even if replaced by C 3~10 It is a cycloalkyl group.

[0390] In some embodiments, R7 is one or more R 10 It is a C3 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C4 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C5 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C6 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C7 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C8 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C9 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 Even if replaced by C 10 It is a cycloalkyl group.

[0391] In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic cycloalkyl that may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic saturated cycloalkyl that may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic partially saturated cycloalkyl that may be substituted with R7. In some embodiments, R7 is one or more R 10 C9~C may be replaced with 10 It is a bicyclic cycloalkyl. In some embodiments, R7 is one or more R 10 C9~C may be replaced with 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R7 is one or more R 10 C9~C may be replaced with 10It is a bicyclic partially saturated cycloalkyl. In some embodiments, R7 is one or more R 10 C8~C may be replaced with 10 It is a polycyclic cycloalkyl compound.

[0392] In some embodiments, R7 is one or more R 10 C replaced by 3~10 It is a cycloalkyl group.

[0393] In some embodiments, R7 is one or more R 10 It is a C3 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C4 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C5 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C6 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C7 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C8 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C9 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 C replaced by 10 It is a cycloalkyl group.

[0394] In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic cycloalkyl substituted with R. In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic saturated cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic partially saturated cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 C9~C replaced by 10It is a bicyclic cycloalkyl. In some embodiments, R7 is one or more R 10 C9~C replaced by 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R7 is one or more R 10 C9~C replaced by 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R7 is one or more R 10 C8~C replaced by 10 It is a polycyclic cycloalkyl compound.

[0395] In some embodiments, R7 is one R 10 C replaced by 3~10 It is a cycloalkyl group.

[0396] In some embodiments, R7 is one R 10 It is a C3 cycloalkyl substituted with R. In some embodiments, R7 is one R 10 It is a C4 cycloalkyl substituted with R. In some embodiments, R7 is one R 10 It is a C5 cycloalkyl substituted with R. In some embodiments, R7 is one R 10 It is a C6 cycloalkyl substituted with R7. In some embodiments, R7 is one R 10 It is a C7 cycloalkyl substituted with R7. In some embodiments, R7 is one R 10 It is a C8 cycloalkyl substituted with R7. In some embodiments, R7 is one R 10 It is a C9 cycloalkyl substituted with R7. In some embodiments, R7 is one R 10 C replaced by 10 It is a cycloalkyl group.

[0397] In some embodiments, R7 is one R 10 It is a C3-C7 monocyclic cycloalkyl substituted with R. In some embodiments, R7 is one R 10 It is a C3-C7 monocyclic saturated cycloalkyl substituted with R. In some embodiments, R7 is one R 10It is a C3-C7 monocyclic partially saturated cycloalkyl substituted with R. In some embodiments, R7 is one R 10 C9~C replaced by 10 It is a bicyclic cycloalkyl. In some embodiments, R7 is one R 10 C9~C replaced by 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R7 is one R 10 C9~C replaced by 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R7 is one R 10 C8~C replaced by 10 It is a polycyclic cycloalkyl compound.

[0398] In some embodiments, R7 is C 3~10 It is a cycloalkyl group.

[0399] In some embodiments, R7 is a C3 cycloalkyl group. In some embodiments, R7 is a C4 cycloalkyl group. In some embodiments, R7 is a C5 cycloalkyl group. In some embodiments, R7 is a C6 cycloalkyl group. In some embodiments, R7 is a C7 cycloalkyl group. In some embodiments, R7 is a C8 cycloalkyl group. In some embodiments, R7 is a C9 cycloalkyl group. In some embodiments, R7 is a C 10 It is a cycloalkyl group.

[0400] In some embodiments, R7 is a C3-C7 monocyclic cycloalkyl. In some embodiments, R7 is a C3-C7 monocyclic saturated cycloalkyl. In some embodiments, R7 is a C3-C7 monocyclic partially saturated cycloalkyl. In some embodiments, R7 is a C9-C 10 It is a bicyclic cycloalkyl. In some embodiments, R7 is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R7 is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R7 is C8~C 10 It is a polycyclic cycloalkyl compound.

[0401] In some embodiments, R7 is one or more R 10 A 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R7s. 10 A three-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A four-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a five-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a six-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R7s. 10 It is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A nine-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with .

[0402] In some embodiments, R7 is one or more R 10 It is a 3- to 10-membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10It is a three-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a four-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a five-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a six-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with [a specific component].

[0403] In some embodiments, R7 is one R 10 It is a 3- to 10-membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is 1 R 10 It is a three-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one R 10 It is a four-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one R 10It is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is 1 R 10 It is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one R 10 It is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R. In some embodiments, R7 is 1 R 10 It is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one R 10 It is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is 1 R 10 It is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with [a specific component].

[0404] In some embodiments, R7 is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0405] In some embodiments, R7 is C 6~10 An aryl or 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl contains one or more R 10 It may be replaced with .

[0406] In some embodiments, R7 is C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0407] In some embodiments, R7 is one or more R 10 Even if replaced by C 6~10 It is Ariel.

[0408] In some embodiments, R7 is one or more R 10 Even if replaced by C 6~8 It is an arrow. In some embodiments, R7 is one or more R 10 It is a phenyl compound that may be substituted with [another compound].

[0409] In some embodiments, R7 is one or more R 10 C replaced by 6~8 It is an arrow. In some embodiments, R7 is one or more R 10 It is a phenyl compound substituted with [a specific compound].

[0410] In some embodiments, R7 is one R 10 C replaced by 6~8 It is an arrow. In some embodiments, R7 is one R 10 It is a phenyl compound substituted with [a specific compound].

[0411] In some embodiments, R7 is C 6~10 It is Ariel.

[0412] In some embodiments, R7 is C 6~8It is an aryl compound. In some embodiments, R7 is a phenyl compound.

[0413] In some embodiments, R7 is one or more R 10 A 5-10 membered heteroaryl comprising 1-4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A five-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A six-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A 7-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is an 8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A nine-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with other elements.

[0414] In some embodiments, R7 is one or more R 10 It is a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a five-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10It is a six-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10 It is a 7-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10 It is an 8-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10 It is a 9-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10 It is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with [a specific component].

[0415] In some embodiments, R7 is one R 10 It is a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is 1 R 10 It is a 5-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one R 10 It is a 6-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one R 10 It is a 7-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is 1 R 10 It is an 8-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one R 10 It is a 9-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one R 10 It is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with [a specific component].

[0416] In some embodiments, R7 is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0417] In some embodiments, R7 is cyclopropyl, piperidine, tetrahydropyran, morpholine, phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0418] In some embodiments, R7 is cyclopropyl, piperidine, tetrahydropyran, or morpholine.

[0419] In some embodiments, R7 is phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0420] In some embodiments, R7 is pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0421] In some embodiments, R7 is a pyridine or pyrimidine.

[0422] In some embodiments, R7 is tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0423] In some embodiments, R7 is a tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, or imidazole.

[0424] In some embodiments, R7 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0425] In some embodiments, R7 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, or benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole.

[0426] In some embodiments, R7 is 9H-carbazole.

[0427] In some embodiments, R7 is oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , C 1~6 Alkyl, C 2~6 Alkinyl, -O-(CH2) t -R8, C 6~10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, aryl, or heteroaryl is one or more R 10 It may be replaced with .

[0428] In some embodiments, R7 is oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , C 1~6 Alkyl, C 2~6 Alkinyl, -O-(CH2) t -R8, C 6~10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, aryl, or heteroaryl is one or more R 10 It has been replaced with.

[0429] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms.

[0430] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0431] In some embodiments, R8 is -OH, C1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2, -SH, or -S(C 1~6 The alkyl group is wherein the alkoxy or alkyl group may be substituted with one or more R9 groups.

[0432] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2, -SH, or -S(C 1~6 The alkyl group is, where the alkoxy or alkyl group is substituted with one or more R9 atoms.

[0433] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2, -SH, or -S(C 1~6 The alkyl group is, where the alkoxy or alkyl group is substituted with one R9.

[0434] In some embodiments, R8 may be replaced by one or more R9s. 1~6 It is an alkoxy.

[0435] In some embodiments, R8 is C 1~6 It is an alkoxy-OH group, where the alkoxy may be substituted with one or more R9 groups.

[0436] In some embodiments, R8 is replaced by one or more R9s. 1~6 It is an alkoxy.

[0437] In some embodiments, R8 is C 1~6It is an alkoxy-OH group, where the alkoxy is substituted with one or more R9 groups.

[0438] In some embodiments, R8 is replaced by a single R9. 1~6 It is an alkoxy.

[0439] In some embodiments, R8 is C 1~6 It is an alkoxy-OH group, where the alkoxy is substituted with one R9 group.

[0440] In some embodiments, R8 is -NH(C 1~6 The alkyl group is an alkyl group, where the alkyl group may be substituted with one or more R9 groups.

[0441] In some embodiments, R8 is -N(C 1~6 The alkyl group is R92, where the alkyl group may be substituted with one or more R9 groups.

[0442] In some embodiments, R8 is -NH(C 1~6 The alkyl group is substituted with one or more R9 atoms.

[0443] In some embodiments, R8 is -N(C 1~6 The alkyl group is R92, where the alkyl group is substituted with one or more R9 atoms.

[0444] In some embodiments, R8 is -NH(C 1~6 It is an alkyl group, where the alkyl group is substituted with one R9.

[0445] In some embodiments, R8 is -N(C 1~6 It is alkyl)2, where the alkyl is substituted with one R9.

[0446] In some embodiments, R8 is -S(C 1~6 The alkyl group is an alkyl group, where the alkyl group may be substituted with one or more R9 groups.

[0447] In some embodiments, R8 is -S(C 1~6 The alkyl group is substituted with one or more R9 atoms.

[0448] In some embodiments, R8 is -S(C 1~6 It is an alkyl group, where the alkyl group is substituted with one R9.

[0449] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C) 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 It is alkyl.

[0450] In some embodiments, R8 is -OH, C 1~6 Alkoxy, or C 1~6 It is an alkoxy-OH group.

[0451] In some embodiments, R8 is -OH.

[0452] In some embodiments, R8 is C 1~6 It is an alkoxy. In some embodiments, R8 is methoxy. In some embodiments, R8 is ethoxy. In some embodiments, R8 is propoxy. In some embodiments, R8 is butoxy. In some embodiments, R8 is pentoxy. In some embodiments, R8 is hexoxy. In some embodiments, R8 is isopropoxy. In some embodiments, R8 is isobutoxy. In some embodiments, R8 is isopentoxy. In some embodiments, R8 is isohexoxy. In some embodiments, R8 is secbutoxy. In some embodiments, R8 is secpentoxy. In some embodiments, R8 is sechexoxy. In some embodiments, R8 is tertbutoxy.

[0453] In some embodiments, R8 is C1~6 It is an alkoxy-OH group. In some embodiments, R8 is a methoxy-OH group. In some embodiments, R8 is an ethoxy-OH group. In some embodiments, R8 is a propoxy-OH group. In some embodiments, R8 is a butoxy-OH group. In some embodiments, R8 is a pentoxy-OH group. In some embodiments, R8 is a hexoxy-OH group. In some embodiments, R8 is an isopropoxy-OH group. In some embodiments, R8 is an isobutoxy-OH group. In some embodiments, R8 is an isopentoxy-OH group. In some embodiments, R8 is an isohexoxy-OH group. In some embodiments, R8 is a sec-butoxy-OH group. In some embodiments, R8 is a sec-pentoxy-OH group. In some embodiments, R8 is a sec-hexoxy-OH group. In some embodiments, R8 is a tert-butoxy-OH group.

[0454] In some embodiments, R8 is -NH2, -NH(C 1~6 Alkyl), or -N(C 1~6 It is alkyl(2).

[0455] In some embodiments, R8 is -NH2.

[0456] In some embodiments, R8 is -NH(C 1~6It is alkyl. In some embodiments, R8 is -NH (methyl). In some embodiments, R8 is -NH (ethyl). In some embodiments, R8 is -NH (propyl). In some embodiments, R8 is -NH (butyl). In some embodiments, R8 is -NH (pentyl). In some embodiments, R8 is -NH (hexyl). In some embodiments, R8 is -NH (isopropyl). In some embodiments, R8 is -NH (isobutyl). In some embodiments, R8 is -NH (isopentyl). In some embodiments, R8 is -NH (isohexyl). In some embodiments, R8 is -NH (sec-butyl). In some embodiments, R8 is -NH (sec-pentyl). In some embodiments, R8 is -NH (sec-hexyl). In some embodiments, R8 is -NH (tert-butyl).

[0457] In some embodiments, R8 is -N(C 1~6 R8 is alkyl)2. In some embodiments, R8 is -N(methyl)2. In some embodiments, R8 is -N(ethyl)2. In some embodiments, R8 is -N(propyl)2. In some embodiments, R8 is -N(butyl)2. In some embodiments, R8 is -N(pentyl)2. In some embodiments, R8 is -N(hexyl)2. In some embodiments, R8 is -N(isopropyl)2. In some embodiments, R8 is -N(isobutyl)2. In some embodiments, R8 is -N(isopentyl)2. In some embodiments, R8 is -N(isohexyl)2. In some embodiments, R8 is -N(secbutyl)2. In some embodiments, R8 is -N(secpentyl)2. In some embodiments, R8 is -N(sechexyl)2. In some embodiments, R8 is -N(tertbutyl)2.

[0458] In some embodiments, R8 is -SH or -S(C 1~6 It is alkyl.

[0459] In some embodiments, R8 is -SH.

[0460] In some embodiments, R8 is -S(C 1~6 It is alkyl.

[0461] In some embodiments, R8 is -S (methyl). In some embodiments, R8 is -S (ethyl). In some embodiments, R8 is -S (propyl). In some embodiments, R8 is -S (butyl). In some embodiments, R8 is -S (pentyl). In some embodiments, R8 is -S (hexyl). In some embodiments, R8 is -S (isopropyl). In some embodiments, R8 is -S (isobutyl). In some embodiments, R8 is -S (isopentyl). In some embodiments, R8 is -S (isohexyl). In some embodiments, R8 is -S (sec-butyl). In some embodiments, R8 is -S (sec-pentyl). In some embodiments, R8 is -S (sec-hexyl). In some embodiments, R8 is -S (tert-butyl).

[0462] In some embodiments, R8 is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms.

[0463] In some embodiments, R8 is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0464] In some embodiments, R8 is C 3~10A cycloalkyl or a 3-10 membered heterocycline comprising 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline may be substituted with one or more R9 atoms.

[0465] In some embodiments, R8 is C 3~10 It is a cycloalkyl or a 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0466] In some embodiments, R8 may be replaced by one or more R9s. 3~10 It is a cycloalkyl group.

[0467] In some embodiments, R8 is a C3 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C4 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C5 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C6 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C7 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C8 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C9 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C 10 It is a cycloalkyl group.

[0468] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl group which may be substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl group which may be substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl group which may be substituted with one or more R9s. In some embodiments, R8 is a C9-C7 monocyclic partially saturated cycloalkyl group which may be substituted with one or more R9s.10 It is a bicyclic cycloalkyl group. In some embodiments, R8 may be substituted with one or more R9s. 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R8 may be substituted with one or more R9s C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R8 may be substituted with one or more R9s C8~C 10 It is a polycyclic cycloalkyl compound.

[0469] In some embodiments, R8 is replaced by one or more R9s. 3~10 It is a cycloalkyl group.

[0470] In some embodiments, R8 is a C3 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C4 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C5 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C6 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C7 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C8 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C9 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C3 cycloalkyl group substituted with one or more R9 groups. 10 It is a cycloalkyl group.

[0471] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C9-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R9s. 10It is a bicyclic cycloalkyl. In some embodiments, R8 is substituted with one or more R9s, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R8 is substituted with one or more R9s, C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R8 is a C8-C substituted with one or more R9s. 10 It is a polycyclic cycloalkyl compound.

[0472] In some embodiments, R8 is replaced by a single R9. 3~10 It is a cycloalkyl group.

[0473] In some embodiments, R8 is a C3 cycloalkyl substituted with one R9. In some embodiments, R8 is a C4 cycloalkyl substituted with one R9. In some embodiments, R8 is a C5 cycloalkyl substituted with one R9. In some embodiments, R8 is a C6 cycloalkyl substituted with one R9. In some embodiments, R8 is a C7 cycloalkyl substituted with one R9. In some embodiments, R8 is a C8 cycloalkyl substituted with one R9. In some embodiments, R8 is a C9 cycloalkyl substituted with one R9. In some embodiments, R8 is a C3 cycloalkyl substituted with one R9. 10 It is a cycloalkyl group.

[0474] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl group substituted with one R9. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one R9. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one R9. In some embodiments, R8 is a C9-C7 monocyclic partially saturated cycloalkyl group substituted with one R9. 10 It is a bicyclic cycloalkyl group. In some embodiments, R8 is substituted with one R9, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R8 is substituted with one R9, C9~C 10It is a bicyclic partially saturated cycloalkyl. In some embodiments, R8 is a C8-C substituted with one R9. 10 It is a polycyclic cycloalkyl compound.

[0475] In some embodiments, R8 is C 3~10 It is a cycloalkyl group.

[0476] In some embodiments, R8 is a C3 cycloalkyl group. In some embodiments, R8 is a C4 cycloalkyl group. In some embodiments, R8 is a C5 cycloalkyl group. In some embodiments, R8 is a C6 cycloalkyl group. In some embodiments, R8 is a C7 cycloalkyl group. In some embodiments, R8 is a C8 cycloalkyl group. In some embodiments, R8 is a C9 cycloalkyl group. In some embodiments, R8 is a C 10 It is a cycloalkyl group.

[0477] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl. In some embodiments, R8 is a C9-C 10 It is a bicyclic cycloalkyl. In some embodiments, R8 is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R8 is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R8 is C8~C 10 It is a polycyclic cycloalkyl compound.

[0478] In some embodiments, R8 is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s. In some embodiments, R8 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s. In some embodiments, R8 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s. In some embodiments, R8 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s. In some embodiments, R8 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s. In some embodiments, R8 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s. In some embodiments, R8 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s. In some embodiments, R8 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s. In some embodiments, R8 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s.

[0479] In some embodiments, R8 is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s.

[0480] In some embodiments, R8 is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9.

[0481] In some embodiments, R8 is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0482] In some embodiments, R8 is C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl may be substituted with one or more R9 atoms.

[0483] In some embodiments, R8 is C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0484] In some embodiments, R8 may be replaced by one or more R9s. 6~10 It is Ariel.

[0485] In some embodiments, R8 may be replaced by one or more R9s. 6~8It is an aryl compound. In some embodiments, R8 is a phenyl compound which may be substituted with one or more R9s.

[0486] In some embodiments, R8 is replaced by one or more R9s. 6~8 It is an aryl compound. In some embodiments, R8 is a phenyl compound substituted with one or more R9s.

[0487] In some embodiments, R8 is replaced by a single R9. 6~8 It is an aryl compound. In some embodiments, R8 is a phenyl compound substituted with one R9.

[0488] In some embodiments, R8 is C 6~10 It is Ariel.

[0489] In some embodiments, R8 is C 6~8 It is an aryl compound. In some embodiments, R8 is a phenyl compound.

[0490] In some embodiments, R8 is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9 atoms. In some embodiments, R8 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9 atoms. In some embodiments, R8 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9 atoms. In some embodiments, R8 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9 atoms. In some embodiments, R8 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9 atoms. In some embodiments, R8 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9 atoms. In some embodiments, R8 is a 10-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R9s.

[0491] In some embodiments, R8 is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 10-membered heteroaryl ion comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R9s.

[0492] In some embodiments, R8 is a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 5-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 6-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 7-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is an 8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 9-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 10-membered heteroaryl ion comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one R9.

[0493] In some embodiments, R8 is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0494] In some embodiments, R8 is H, -OH, C 1~6 Alkoxy, C 1~6Alkoxy-OH, -NH2, -N(C) 1~6 Alkyl)2,-S(C 1~6 A 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from alkyl, N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl may be substituted with one or more R9 atoms.

[0495] In some embodiments, R8 is H, -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -N(C) 1~6 Alkyl)2,-S(C 1~6 A 3- to 10-membered heterocyclyl containing 1 to 4 heteroatoms selected from alkyl, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl is substituted with one or more R9 atoms.

[0496] In some embodiments, each R9 is independently -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 The heteroaryl or aryl is substituted with one or more halogens, -CN, -OH, or -NH2.

[0497] In some embodiments, R9 is -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 It is Ariel.

[0498] In some embodiments, R9 is -(CH2) u-(a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where the heteroaryl may be substituted with one or more halogens, -CN, -OH, or -NH2.

[0499] In some embodiments, R9 is -(CH2) u -(5-membered heteroaryl), where the heteroaryl may be substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(6-membered heteroaryl), where the heteroaryl may be substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(7-membered heteroaryl), where the heteroaryl may be substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(8-membered heteroaryl), where the heteroaryl may be substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(9-membered heteroaryl), where the heteroaryl may be substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(10-membered heteroaryl), where the heteroaryl may be substituted with one or more halogens, -CN, -OH, or -NH2.

[0500] In some embodiments, R9 is -(CH2) u -(a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one or more halogens, -CN, -OH, or -NH2.

[0501] In some embodiments, R9 is -(CH2) u-(a five-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(a six-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(a 7-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(an 8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(a 9-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(a 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one or more halogens, -CN, -OH, or -NH2.

[0502] In some embodiments, R9 is -(CH2) u -(a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one halogen, -CN, -OH, or -NH2.

[0503] In some embodiments, R9 is -(CH2) u-(a five-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(a six-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(a 7-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(an 8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(a 9-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(a 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where the heteroaryl is substituted with one halogen, -CN, -OH, or -NH2.

[0504] In some embodiments, R9 is -(CH2) u -(A 5-10 member heteroaryl compound containing 1-4 heteroatoms selected from N, O, and S).

[0505] In some embodiments, R9 is -(CH2) u -(a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2) u-(a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2) u -(a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2) u -(an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2) u -(a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2) u -(A 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S).

[0506] In some embodiments, R9 is -(CH2) u -(C 6~10 R9 is an aryl group, where the aryl group may be substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(C 6~8 R9 is an aryl group, where the aryl group may be substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(phenyl), where phenyl may be substituted with one or more halogens, -CN, -OH, or -NH2.

[0507] In some embodiments, R9 is -(CH2) u -(C 6~10 R9 is an aryl group, where the aryl group is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(C 6~8 R9 is an aryl group, where the aryl group is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u-(phenyl), where the phenyl is substituted with one or more halogens, -CN, -OH, or -NH2.

[0508] In some embodiments, R9 is -(CH2) u -(C 6~10 R9 is an aryl group, where the aryl group is substituted with one halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(C 6~8 R9 is an aryl group, where the aryl group is substituted with one halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2) u -(phenyl), where the phenyl is substituted with one halogen, -CN, -OH, or -NH2.

[0509] In some embodiments, R9 is -(CH2) u -(C 6~10 It is aryl). In some embodiments, R9 is -(CH2) u -(C 6~8 It is aryl). In some embodiments, R9 is -(CH2) u -(phenyl)

[0510] In some embodiments, R9 is -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 The heteroaryl or aryl is substituted with one or more halogens or -OH groups.

[0511] In some embodiments, R9 is -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 The heteroaryl or aryl is substituted with one or more halogens or -OH groups.

[0512] In some embodiments, each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0513] In some embodiments, R 10 These are halogens, -OH, -NH2, or -CN.

[0514] In some embodiments, R 10 It is a halogen.

[0515] In some embodiments, R 10 is F, Cl, Br, or I. In some embodiments, R 10 It is F, Cl, or Br.

[0516] In some embodiments, R 10 is F. In some embodiments, R 10 is Cl. In some embodiments, R 10 is Br. In some embodiments, R 10 It is I.

[0517] In some embodiments, R 10 is -OH. In some embodiments, R 10 is -NH2. In some embodiments, R 10 is -CN.

[0518] In some embodiments, R 10 is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0519] In some embodiments, R 10 is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, or C 1~6 It is a haloalkyl group.

[0520] In some embodiments, R 10 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0521] In some embodiments, R 10 is C 1~6 It is alkyl. In some embodiments, R 10 is methyl. In some embodiments, R 10 is ethyl. In some embodiments, R 10 is propyl. In some embodiments, R 10 is butyl. In some embodiments, R 10 is pentyl. In some embodiments, R 10 is hexyl. In some embodiments, R 10 is isopropyl. In some embodiments, R 10 isobutyl. In some embodiments, R 10 is isopentyl. In some embodiments, R 10 is isohexyl. In some embodiments, R 10 is secbutyl. In some embodiments, R 10 secpentyl is secpentyl. In some embodiments, R 10 is sec hexyl. In some embodiments, R 10 It is tert-butyl.

[0522] In some embodiments, R 10 is C 2~6 It is an alkenil. In some embodiments, R 10 is a C2 alkenyl. In some embodiments, R 10 is a C3 alkenyl. In some embodiments, R 10 is a C4 alkenyl. In some embodiments, R 10 is a C5 alkenyl. In some embodiments, R 10 This is a C6 alkenyl.

[0523] In some embodiments, R 10 is C 2~6 It is alkinyl. In some embodiments, R 10 is C2 alkynyl. In some embodiments, R 10 is C3 alkynyl. In some embodiments, R 10 is C4 alkynyl. In some embodiments, R 10 is C5 alkynyl. In some embodiments, R 10 This is a C6 alkynyl.

[0524] In some embodiments, R 10 is C 1~6 It is a haloalkyl. In some embodiments, R 10 is a halomethyl. In some embodiments, R 10 is haloethyl. In some embodiments, R 10 is a halopropyl. In some embodiments, R 10 is halobutyl. In some embodiments, R 10 is halopentyl. In some embodiments, R 10 It is a halohexyl.

[0525] In some embodiments, R 10 is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0526] In some embodiments, R 10 is C 3~10 It is a cycloalkyl or a 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0527] In some embodiments, R 10 is C 3~10 It is a cycloalkyl group.

[0528] In some embodiments, R 10 R is a C3 cycloalkyl. In some embodiments, R 10 R is a C4 cycloalkyl. In some embodiments, R 10 R is a C5 cycloalkyl. In some embodiments, R 10 is a C6 cycloalkyl. In some embodiments, R 10 R is a C7 cycloalkyl. In some embodiments, R 10 is a C8 cycloalkyl. In some embodiments, R 10 is a C9 cycloalkyl. In some embodiments, R 10 is C 10 It is a cycloalkyl group.

[0529] In some embodiments, R 10 R is a C3-C7 monocyclic cycloalkyl. In some embodiments, R 10 R is a C3-C7 monocyclic saturated cycloalkyl. In some embodiments, R 10 R is a C3-C7 monocyclic partially saturated cycloalkyl. In some embodiments, R 10 is C9~C 10 It is a bicyclic cycloalkyl. In some embodiments, R 10 is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R 10 is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R10 is C8~C 10 It is a polycyclic cycloalkyl compound.

[0530] In some embodiments, R 10 It is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a three-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a four-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0531] In some embodiments, R 10 is C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0532] In some embodiments, R 10 is C 6~10 It is Ariel.

[0533] In some embodiments, R 10 is C 6~8It is an arrow. In some aspects, R 10 It is phenyl.

[0534] In some embodiments, R 10 R is a 5-10 membered heteroaryl compound containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 R is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 R is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R 10 It is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0535] In some embodiments, R 10 is C 1~6 Alkyl, C 1~6 It is a haloalkyl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0536] In some embodiments, each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, halogen, -CN, -OH, or -NH2.

[0537] In some embodiments, each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2.

[0538] In some embodiments, each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0539] In some embodiments, R 11 H is H.

[0540] In some embodiments, R 11 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~105-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2.

[0541] In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 C may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S. 1~6 Alkyl, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A methyl molecule that may be substituted with an aryl or a 5-10 membered heteroaryl molecule containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl molecule contains one or more C atoms. 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 Ethyl, which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A propyl that may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 Butyl, which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 Pentyl, which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A hexyl which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 isopropyl, which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10Isobutyl is an isobutyl which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 isopentyl, which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10An isohexyl which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 secbutyl, which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10secpentyl, which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A sechexyl which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10Tert-butyl which may be substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2.

[0542] In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 C is substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S. 1~6 Alkyl, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10Methyl is substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 Ethyl substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A propyl substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 Butyl is substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10Pentyls substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A hexyl substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10isopropyl substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 Isobutyl is substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10Isopentyl is substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An isohexyl substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10secbutyl substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 secpentyl substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10sechexyl substituted with an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 It may be substituted with an alkynyl, oxo, halogen, -CN, -OH, or -NH2. In some embodiments, R 11 is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N,...

Claims

1. Compounds of formula (I), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: During the ceremony, A is C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y are each independently H, C 1～6 alkyl, C 2～6 alkenyl, C 2～6 alkynyl, C 1～6 alkoxy, halogen, -CN, -OH, or -NH 2 ; R 1 and R 4 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is alkinyl; R 2 and R 3 These are H and C, which are independent of each other. 2～6 Alkenil, C 2～6 Alkinyl, -OC 1～6 Alkyl, -OC 2～6 Alkenyl, -OC 2～6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 ) 2 -C(O)NR 11 -S(O) 2 R 11 -C(O)NR 11 -S(O) 2 -OR 11 , or -C(O)NR 11 -S(O) 2 -N(R 11 ) 2 And here R 2 R 3 Not H; R 5 and R 6 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5- to 13-membered heteroaryls containing 1 to 4 heteroatoms selected from aryl, N, O, and S, or -C(O)R 7 Here, the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 It may be replaced with, or, R 5 and R 6 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 It may also be replaced with; Each R 7 These are independently oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 ) 2 , C 1～3 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 ,-O-(CH 2 ) t -R 8 -NH-(CH 2 ) t -R 8 , C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R 8 is -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 -SH, -S(C 1～6 Alkyl), C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 9 It may also be replaced with; Each R 9 It is independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 A heteroaryl or aryl is one or more halogens, -CN, -OH, or -NH 2 It may also be replaced with; Each R 10 is independently selected from halogen, -OH, -NH 2 , -CN, C 1～6 alkyl, C 2～6 alkenyl, C 2～6 alkynyl, C 1～6 haloalkyl, C 3～10 cycloalkyl, a 3- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, C 6～10 aryl, or a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, oxo, halogen, -CN, -OH, or -NH 2 It may be replaced with, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 It may also be replaced with; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R 5 and R 6 These atoms, together with the atoms they are bonded to, form heterocyclines or heteroaryls, and A is also phenyl. But no.

2. Compounds of formula (I), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: During the ceremony, A is and; R x and R y These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, halogen, -CN, -OH, or -NH 2 and; R 1 and R 4 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is alkinyl; R 2 and R 3 These are H and C, which are independent of each other. 2～6 Alkenil, C 2～6 Alkinyl, -OC 1～6 Alkyl, -OC 2～6 Alkenyl, -OC 2～6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 ) 2 -C(O)NR 11 -S(O) 2 R 11 -C(O)NR 11 -S(O) 2 -OR 11 , or -C(O)NR 11 -S(O) 2 -N(R 11 ) 2 And here R 2 R 3 Not H; R 5 and R 6 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5- to 13-membered heteroaryls containing 1 to 4 heteroatoms selected from aryl, N, O, and S, or -C(O)R 7 Here, the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 It may be replaced with, or, R 5 and R 6 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 It may also be replaced with; Each R 7 These are independently oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 ) 2 , C 1～3 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 ,-O-(CH 2 ) t -R 8 -NH-(CH 2 ) t -R 8 , C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R 8 is -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 -SH, -S(C 1～6 Alkyl), C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 9 It may also be replaced with; Each R 9 It is independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 A heteroaryl or aryl is one or more halogens, -CN, -OH, or -NH 2 It may also be replaced with; Each R 10 These are independently halogen, -OH, and -NH 2 ,-CN,C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It is a 5- to 10-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, oxo, halogen, -CN, -OH, or -NH 2 It may be replaced with, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 It may also be replaced with; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R 5 and R 6 These, together with the atoms they are bonded to, form a heterocycline, and A is That is the case.

3. Compounds of formula (II), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: During the ceremony, R x and R y These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, halogen, -CN, -OH, or -NH 2 and; R 1 and R 4 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is alkinyl; R 2 and R 3 These are H and C, which are independent of each other. 2～6 Alkenil, C 2～6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 ) 2 -C(O)NR 11 -S(O) 2 R 11 -C(O)NR 11 -S(O) 2 -OR 11 , or -C(O)NR 11 -S(O) 2 -N(R 11 ) 2 And here R 2 R 3 Not H; R 5 and R 6 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5- to 13-membered heteroaryls containing 1 to 4 heteroatoms selected from aryl, N, O, and S, or -C(O)R 7 Here, the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 It may be replaced with, or, R 5 and R 6 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 It may also be replaced with; Each R 7 These are independently oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 ) 2 , C 1～3 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 ,-O-(CH 2 ) t -R 8 -NH-(CH 2 ) t -R 8 , C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R 8 is -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 -SH, -S(C 1～6 Alkyl), C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 9 It may also be replaced with; Each R 9 It is independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 A heteroaryl or aryl is one or more halogens, -CN, -OH, or -NH 2 It may also be replaced with; Each R 10 These are independently halogen, -OH, and -NH 2 ,-CN,C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It is a 5- to 10-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, oxo, halogen, -CN, -OH, or -NH 2 It may be replaced with, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 It may also be replaced with; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3.

4. R x and R y H and C are independent of each other. 1～6 The compound according to any one of the claims, wherein it is alkyl or -OH.

5. R 1 and R 4 Each of them independently is H or C 1～6 The compound according to any one of the above claims, wherein it is alkyl.

6. R 2 and R 3 Each of them operates independently, -OC 1～6 Alkyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 ) 2 , or -C(O)NR 11 -S(O) 2 R 11 The compound according to claim 1 or 2.

7. R 5 and R 6 H and C are independent of each other. 1～6 Alkyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5- to 13-membered heteroaryls containing 1 to 4 heteroatoms selected from aryl, N, O, and S, or -C(O)R 7 Here, the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 The compound according to any one of the claims, which may be substituted with

8. R 5 and R 6 H and C are independent of each other. 1～6 Alkyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5- to 13-membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 The compound according to any one of the claims, which may be substituted with

9. R 5 and R 6 H and C are independent of each other. 1～6 Alkyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5- to 13-membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 The compound according to any one of the claims, which is substituted with

10. R 5 and R 6 However, together with the atoms to which they are bonded, they form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 The compound according to any one of the claims, which is substituted with

11. Each R 7 These independently form oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , C 1～3 Alkyl, C 2～6 Alkinyl, -O-(CH 2 ) t -R 8 , C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, aryl, or heteroaryl comprises one or more R 10 The compound according to any one of the claims, which may be substituted with

12. Each R 7 These independently form oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , C 1～3 Alkyl, C 2～6 Alkinyl, C 1～6 Alkoxy, -O-(CH 2 ) t -R 8 , C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, aryl, or heteroaryl comprises one or more R 10 The compound according to any one of the claims, which is substituted with

13. R 8 However, -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -N(C 1～6 Alkyl) 2 , -S(C 1～6 A 3- to 10-membered heterocyclyl containing 1 to 4 heteroatoms selected from alkyl, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl contains one or more R 9 The compound according to any one of the claims, which may be substituted with

14. R 8 However, -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -N(C 1～6 Alkyl) 2 , -S(C 1～6 A 3- to 10-membered heterocyclyl containing 1 to 4 heteroatoms selected from alkyl, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl contains one or more R 9 The compound according to any one of the claims, which is substituted with

15. Each R 9 It became independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 The compound according to any one of the claims, wherein the heteroaryl or aryl is substituted with one or more halogens or -OH groups.

16. Each R 9 It became independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 The compound according to any one of the claims, wherein the heteroaryl or aryl is substituted with one or more halogens or -OH groups.

17. Each R 10 C 1～6 Alkyl, C 1～6 The compound according to any one of the claims, which is a haloalkyl or a 5-10 membered heteroaryl comprising 1-4 heteroatoms selected from N, O, and S.

18. Each R 11 They became independent, H； One or more 3- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing aryl or 1-4 heteroatoms selected from N, O, and S Even if it is replaced with C 1～6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1～6 The compound according to any one of the claims, which may be substituted with an alkyl group or an oxo group.

19. Each R 11 They became independent, H； One or more 3- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing aryl or 1-4 heteroatoms selected from N, O, and S Even if it is replaced with C 1～6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1～6 The compound according to any one of the claims, which is substituted with an alkyl group or an oxo group.

20. Each R 11 They became independent, H； One or more 3- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing aryl or 1-4 heteroatoms selected from N, O, and S Replaced with, C 1～6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1～6 The compound according to any one of the claims, which may be substituted with an alkyl group or an oxo group.

21. 2 R 11 However, together with the atoms to which they are bonded, One or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 4- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, which may be substituted. A compound according to any one of the above claims, which forms a compound.

22. 2 R 11 However, together with the atoms to which they are bonded, One or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 4- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, substituted with A compound according to any one of the above claims, which forms a compound.

23. The compound according to any one of the claims, wherein each n is 0.

24. The compound according to any one of the claims, wherein each n is 1.

25. The compound according to any one of the claims, wherein each m is 0.

26. The compound according to any one of the claims, wherein each m is 1.

27. The compound according to any one of the claims, wherein each p is 0.

28. The compound according to any one of the claims, wherein each p is 1.

29. R 2 R 3 The compound according to any one of the above claims, which is not H.

30. R 5 and R 6 However, if they combine with the atoms they are bonded to to form a heterocycline or heteroaryl, then A The compound according to any one of the above claims.

31. Compounds of formula (Ia) or (Ib): The compound according to claim 1 or 2, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

32. Compounds of formula (Ic), (Id), or (Ie): The compound according to claim 1 or 2, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

33. Compounds of formula (I-a') or (I-b'): The compound according to claim 1 or 2, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

34. Compound of formula (II-a): The compound according to any one of claims 1 to 3, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

35. Compound of formula (II-a'): The compound according to any one of claims 1 to 3, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

36. A compound according to any one of claims 1 to 3, selected from Table 1.

37. A pharmaceutical composition comprising a compound according to any one of claims 1 to 36, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, and a pharmaceutically acceptable diluent or carrier.

38. A method for modulating P-glycoprotein activity and / or cytochrome P450 activity, comprising the step of contacting cells with an effective amount of a compound according to any one of claims 1 to 36 or a pharmaceutical composition according to claim 37.

39. A method for treating or preventing a disease or disorder disclosed herein in a subject where such treatment is necessary, comprising the step of administering to the subject a therapeutically effective amount of a compound according to any one of claims 1 to 36 or a pharmaceutical composition according to claim 37.

40. A method for treating or preventing cancer in a subject in need, comprising the step of administering to the subject a therapeutically effective amount of a compound according to any one of claims 1 to 36 or a pharmaceutical composition according to claim 37.

41. A compound according to any one of claims 1 to 36 or a pharmaceutical composition according to claim 37 for use in modulating P-glycoprotein activity and / or cytochrome P450 activity.

42. A compound according to any one of claims 1 to 36 or a pharmaceutical composition according to claim 37 for use in treating or preventing any of the diseases or disorders disclosed herein.

43. A compound according to any one of claims 1 to 36 or a pharmaceutical composition according to claim 37 for use in treating or preventing cancer.

44. Use of a compound according to any one of claims 1 to 36 or a pharmaceutical composition according to claim 37 in the manufacture of a pharmacopoeia for modulating P-glycoprotein activity and / or cytochrome P450 activity.

45. Use of a compound according to any one of claims 1 to 36 or a pharmaceutical composition according to claim 37 in the manufacture of a medicament for treating or preventing a disease or disorder disclosed herein.

46. Use of a compound according to any one of claims 1 to 36 or a pharmaceutical composition according to claim 37 in the manufacture of a pharmacopoeia for treating or preventing cancer.

Images