A method of treating IGA nephropathy with atrasentan

Abstract

This provides a method for treating IgA nephropathy. [Solution] A method is provided for treating IgA nephropathy, comprising administering a therapeutically effective amount of atrasentan or a pharmaceutically acceptable salt thereof to a subject in need thereof. Also provided herein is a method for reducing renal inflammation and / or fibrosis, reducing the occurrence of hematuria, stabilizing eGFR, reducing the number of disease flares associated with IgA nephropathy, delaying the onset of ESRD, reducing proteinuria, and reducing fatigue in a subject having IgA nephropathy, comprising administering a therapeutically effective amount of atrasentan or a pharmaceutically acceptable salt thereof to a subject. In some embodiments, the subject has never been previously diagnosed with one or more of the following: diabetic nephropathy, HIV / AIDS, HIV-related nephropathy, prostate cancer, or acute renal failure.

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