Antiviral compounds and methods for producing and using the same

Compounds of formula I and their salts provide effective treatment and prevention of viral infections in Paramyxoviridae, Pneumoviridae, Flaviviridae, Filoviridae, and Orthomyxoviridae families by targeting these viruses and reducing viral load, with enhanced metabolic resistance and broad species applicability.

JP2026094177APending Publication Date: 2026-06-09GILEAD SCIENCES INC
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Patent Information

Application Number
JP2026018586
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-03-03
Filing Date
2026-02-06
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

There is a need for effective compounds and methods to treat infections caused by viral families such as Paramyxoviridae, Pneumoviridae, Flaviviridae, Filoviridae, and Orthomyxoviridae, as existing treatments are inadequate.

Method used

Development of compounds of formula I and their pharmaceutically acceptable salts, which can be administered to prevent or treat viral infections by targeting these viral families, including pharmaceutical compositions and methods for administration.

Benefits of technology

The compounds effectively prevent or treat viral infections by reducing viral load and alleviating symptoms, with the potential for increased half-life and resistance to metabolism through deuterium substitution, and applicability to various animal species.

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Abstract

To provide a method for treating a disease. [Solution] Disclosed are an antiviral compound of formula I, a method of using the antiviral compound alone or in combination with further agents, and a pharmaceutical composition of the antiviral compound for treating viral infections. Surprisingly, remarkable effects are achieved according to the present invention, as described in detail and demonstrated concretely herein, and these remarkable effects were not readily predictable to those skilled in the art from the prior art. TIFF2026094177000204.tif23128
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