Safety syringe systems and methods

Abstract

This invention provides systems and methods related to multi-chamber safety syringes in a medical setting. [Solution] A system for continuously injecting liquid includes a syringe body, proximal and distal stopper members disposed within the syringe body, a first liquid in the distal chamber, a second liquid in the proximal chamber, a plunger member, and a needle hub assembly coupled to the distal needle interface of the syringe body. The plunger includes a needle holding feature, an energy storage member, and an energy storage member latch member disposed within the plunger. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latch member configured to connect the needle to the hub. When the plunger member is operated to insert the proximal stopper member distally relative to the syringe body, the first liquid is discharged first, followed by the second liquid. The needle is retractable at least partially into the plunger.

Claims

1. A system for continuously injecting liquid, A syringe body comprising a syringe body that defines the proximal opening of the syringe and the distal needle interface at the distal end, A proximal stopper member and a distal stopper member disposed on the syringe body, wherein a proximal chamber is formed between the proximal stopper member and the distal stopper member, and a distal chamber is formed between the distal stopper member and the distal end of the syringe body, The first liquid in the distal chamber, The second liquid in the proximal chamber, A plunger member that defines the inside of the plunger and is configured to be manually operated to insert the proximal stopper member distally relative to the syringe body, The needle-holding feature portion arranged inside the plunger, An energy storage member disposed inside the plunger, A plunger member including an energy storage member latch member disposed inside the plunger, A needle hub assembly coupled to the distal needle interface of the syringe body, A needle having a characteristic portion at the proximal end, Hub and, The needle hub assembly includes a needle latch member configured to connect the needle to the hub, By operating the plunger member to insert the proximal stopper member distally relative to the syringe body, the first liquid is first discharged from the distal chamber through the needle, and then the second liquid is continuously discharged from the proximal chamber through the needle. A system characterized in that, in response to the relative operation of the plunger member with respect to the syringe body, the energy storage member latch member is converted from a latched state to an unlatched state, thereby allowing the needle to be retracted at least partially into the plunger.

2. In the system described in claim 1, A system characterized in that the first and second sizes of the distal chamber and proximal chamber, respectively, can be changed by the relative movement of the proximal and distal stopper members with respect to the syringe body.

3. In the system described in claim 1, The system is characterized in that the needle defines the inside of the needle, the distal end opening, the intermediate opening, and the proximal opening, and the distal end opening, the intermediate opening, and the proximal opening are fluidly connected via the inside of the needle.

4. In the system described in claim 3, A system characterized in that the distance between the proximal opening and the distal end of the syringe body is approximately equal to the length of the distal stopper member, and when the distal stopper member is inserted into the distal end of the syringe body, the proximal stopper member is inserted distally to the needle, and the proximal opening is positioned in the proximal chamber.

5. In the system described in claim 3, A system characterized in that the proximal stopper member, the distal stopper member, and the syringe body are configured such that a distal force applied to the proximal stopper member is transmitted to the distal stopper member via the second liquid until the proximal stopper member is inserted distally relative to the needle and the proximal opening is positioned in the proximal chamber.

6. In the system described in claim 3, The system, A first injection configuration in which the proximal opening is located within the distal chamber, A system characterized by having a second injection configuration, wherein the proximal opening is located within the proximal chamber, thereby transferring the second liquid from the proximal chamber through the proximal opening and the inside of the needle to exit the distal end opening.

7. In the system described in claim 6, A system characterized in that, when the system is in the second injection configuration, the distal stopper member closes the intermediate opening.

8. In the system described in claim 1, The system is characterized in that the needle is configured to penetrate at least the distal stopper member completely and be retracted at least partially into the plunger.

9. In the system described in claim 1, The system is characterized in that the proximal and distal stopper members include first and second polymer coatings on their respective distal and proximal surfaces, and the proximal chamber is defined by the syringe body and the first and second polymer coatings.

10. In the system described in claim 1, The system is characterized in that the distal stopper member has a funnel that tapers in the proximal direction and a space located at the proximal end of the tapering funnel.

11. In the system according to claim 10, The system is characterized in that the funnel is configured to guide the proximal end feature portion of the needle into the space at the tapered proximal end of the funnel, thereby aligning the proximal end feature portion of the needle with the needle holding feature portion inside the plunger.

12. In the system according to claim 11, The system is characterized in that the funnel is configured to align the needle proximal end feature with the needle holding feature inside the plunger during the assembly of the system.

13. In the system according to claim 11, The system is characterized in that the funnel is configured to align the proximal end feature of the needle with the needle holding feature inside the plunger during the operation of the plunger member for inserting the proximal stopper member distally to the syringe body.

14. In the system described in claim 1, The system is characterized in that the energy storage member latch member is configured to be converted from a latched state to an unlatched state after the second liquid has been discharged from the proximal chamber via the needle, thereby pulling the needle at least partially into the plunger.

15. In the system described in claim 1, The system is characterized in that the needle-holding feature is configured to activate the conversion of the energy storage member latch member from a latched state to an unlatched state in response to the operation of the plunger member for inserting the proximal stopper member into the distal end of the syringe body.

16. In the system described in claim 1, The system is characterized in that the needle includes a transport pipe having a proximal end and a distal end.

17. A method for continuously injecting a first liquid and a second liquid into a patient, A step of providing a system, wherein the system A syringe body that defines the proximal opening and distal end of the syringe, A proximal stopper member and a distal stopper member disposed on the syringe body, wherein a proximal chamber containing the second liquid is formed between the proximal stopper member and the distal stopper member, and a distal chamber containing the first liquid is formed between the distal stopper member and the distal end of the syringe body, A plunger member that defines the inside of the plunger and is configured to be manually operated to insert the proximal stopper member distally relative to the syringe body, A needle having an internal core, a distal end opening, an intermediate opening, and a proximal opening, wherein the distal end opening, the intermediate opening, and the proximal opening are fluidly connected through the internal core of the needle; The steps include advancing the plunger member to discharge the first liquid from the distal chamber through the inside of the needle and the distal end opening, The steps include further advancing the plunger member to discharge the second liquid from the proximal chamber through the proximal opening, the inside of the needle, and the distal end opening, A method characterized by comprising the step of automatically retracting the distal needle tip into the needle hub or the syringe body when the first and second liquids are injected into the patient.

18. In the method according to claim 17, A method further comprising the step of inserting the distal end of the needle into the patient before advancing the plunger member to discharge the first liquid from the distal chamber, thereby positioning the distal end opening of the needle in the patient before discharging the first liquid.

19. In the method according to claim 18, A method further comprising the step of removing air from the distal chamber before inserting the distal end of the needle into the patient.

20. In the method according to claim 19, The step of removing air from the distal chamber is, The steps include: holding the syringe body in a nearly vertical position; A method characterized by including the step of operating the plunger member to insert the proximal stopper member distally relative to the syringe body.

21. In the method according to claim 17, A method characterized by advancing the plunger member to insert the proximal stopper member distally relative to the syringe body, thereby applying a distal force through the second liquid to insert the distal stopper member distally relative to the syringe body, thereby discharging the first liquid from the distal chamber through the inside of the needle and the distal end opening.

22. In the method according to claim 17, The aforementioned system A first injection configuration in which the proximal opening is located in the distal chamber, The proximal opening is positioned in the proximal chamber, thereby enabling the transfer of the second liquid from the proximal chamber through the proximal opening and the inside of the needle to the outside of the distal end opening, The system is in the first injection configuration when the plunger member moves forward and discharges the first liquid from the distal chamber through the inside of the needle and the distal end opening. The system is characterized in that it is in the second injection configuration when the plunger member moves further forward to discharge the second liquid from the proximal chamber through the proximal opening, the inside of the needle, and the distal end opening.

23. In the method of claim 22, A method characterized in that the distal stopper member closes the intermediate opening when the system is in the second injection configuration.

24. In the method according to claim 17, The steps include: the needle completely penetrating at least the distal stopper member; A method further comprising the step of retracting the needle at least partially into the plunger.

25. In the method according to claim 17, The method is characterized in that the needle includes a transport pipe having a proximal end and a distal end.

26. In the method according to claim 17, The distal stopper member is A funnel that tapers towards the proximal end, The funnel has a space located at its tapering proximal end, The method further includes the step of guiding the needle into a space at the tapered proximal end of the funnel, thereby aligning the proximal end feature of the needle with the needle-holding feature inside the plunger.

27. In the method according to claim 17, The needle further has a characteristic portion at the proximal end of the needle, and the distal stopper member has a detent. The method further comprises the step of the detent resisting the passage of the needle proximal end feature.

28. In the method according to claim 27, A method characterized in that advancing the plunger member to discharge the first liquid from the distal chamber through the inside of the needle and the distal end opening includes applying a distal force to the plunger member to overcome the resistance to the proximal end feature portion of the needle passing through the detent.

29. In the method of claim 28, A method characterized in that the distal force is approximately 2 pounds to approximately 5 pounds.

30. In the method according to claim 17, The needle further has a shoulder portion, and the distal stopper member has a detent, The method further comprises the step of the detent resisting the passage of the shoulder portion.

31. In the method according to claim 30, A method characterized in that further advancing the plunger member to discharge the second liquid from the proximal chamber through the proximal opening, the inside of the needle, and the distal end opening includes applying a distal force to the plunger member to overcome the resistance to the shoulder passing through the detent.

32. In the method according to claim 31, A method characterized in that the distal force is approximately 2 pounds to approximately 5 pounds.

33. In the method according to claim 17, The needle further has a groove, and the distal stopper member has a detent, The method further comprises the step of the detent resisting passage through the groove.

34. In the method according to claim 33, A method characterized in that further advancing the plunger member to discharge the second liquid from the proximal chamber through the proximal opening, the inside of the needle, and the distal end opening includes applying a distal force to the plunger member to overcome the resistance to the groove passing through the detent.

35. In the method according to claim 34, A method characterized in that the distal force is approximately 2 pounds to approximately 5 pounds.

36. In the system described in claim 1, The system is characterized in that the distal stopper member has a detent that resists the passage of the proximal end feature portion of the needle.

37. In the system described in claim 36, The system is characterized in that the detent is configured such that a distal force of about 2 to 5 pounds applied to the plunger member overcomes the resistance to the passage of the needle's proximal end feature.

38. In the system described in claim 37, A system characterized in that the detent is adjustable in order to adjust the distal force required to overcome resistance.

39. In the system described in claim 36, A system characterized in that the detent has a "U" shape.

40. In the system described in claim 36, The system is characterized in that the detent includes a bent wire.

41. In the system described in claim 36, The system is characterized in that the detent has a flattened cross-section.

42. In the system described in claim 36, The system is characterized in that the detent has a needle proximal end feature receiving feature portion.

43. In the system according to claim 42, The system is characterized in that the needle proximal end feature portion receiving feature portion has a chamfered surface.

44. In the system described in claim 36, The system is characterized in that the detent contains an annealed stainless steel alloy.

45. In the system described in claim 36, The system is characterized in that the proximal end feature portion of the needle has an angle of approximately 30 degrees.

46. In the system described in claim 36, The system is characterized in that the needle has a shoulder portion to resist the needle passing through the detent.

47. In the system described in claim 46, The system is characterized in that the shoulder portion and the detent are configured such that they overcome the resistance to the shoulder portion passing through the detent by a distal force of about 2 to 5 pounds applied to the plunger member.

48. In the system described in claim 47, A system characterized in that the detent is adjustable in order to adjust the distal force required to overcome resistance.

49. In the system described in claim 46, The system is characterized in that the shoulder portion has an angle of approximately 50 degrees.

50. In the system described in claim 36, The system is characterized in that the needle has a groove to resist the needle passing through the detent.

51. In the system described in claim 50, The system is characterized in that the groove and the detent are configured such that they overcome the resistance to the groove passing through the detent by a distal force of about 2 to 5 pounds applied to the plunger member.

52. In the system described in claim 51, A system characterized in that the detent is adjustable in order to adjust the distal force required to overcome resistance.

53. A system for continuously injecting liquid, A syringe body comprising a syringe body that defines the proximal opening of the syringe and the distal interface at the distal end, A proximal stopper member and a distal stopper member disposed on the syringe body, wherein a proximal chamber is formed between the proximal stopper member and the distal stopper member, and a distal chamber is formed between the distal stopper member and the distal end of the syringe body, The first liquid in the distal chamber, The second liquid in the proximal chamber, A plunger member configured to be manually operated to insert the proximal stopper member distally relative to the syringe body, A hub assembly coupled to the distal interface of the syringe body, A transport pipe having a proximal end and a distal end, Hub and, The hub assembly includes a connector fluidly coupled to the distal end of the transfer pipe, A system characterized by first discharging the first liquid from the distal chamber via the transfer pipe, and then continuously discharging the second liquid from the proximal chamber via the transfer pipe, by operating the plunger member to insert the proximal stopper member distally to the syringe body.

54. In the system described in claim 53, A system characterized in that the first and second sizes of the distal chamber and proximal chamber, respectively, can be changed by the relative movement of the proximal and distal stopper members with respect to the syringe body.

55. In the system described in claim 53, The system is characterized in that the transfer pipe defines the interior of the transfer pipe, a distal end opening at the distal end of the transfer pipe, an intermediate opening, and a proximal opening, and the distal end opening, the intermediate opening, and the proximal opening are fluidly connected via the interior of the transfer pipe.

56. In the system described in claim 55, A system characterized in that the distance between the proximal opening and the distal end of the syringe body is approximately equal to the length of the distal stopper member, and when the distal stopper member is inserted into the distal end of the syringe body, the proximal stopper member is inserted distally relative to the transfer pipe, and the proximal opening is positioned in the proximal chamber.

57. In the system described in claim 55, A system characterized in that the proximal stopper member, the distal stopper member, and the syringe body are configured such that a distal force applied to the proximal stopper member is transmitted to the distal stopper member via the second liquid until the proximal stopper member is inserted distally into the transfer pipe and the proximal opening is positioned in the proximal chamber.

58. In the system described in claim 55, The system, A first injection configuration in which the proximal opening is located within the distal chamber, A system characterized by having a second injection configuration, wherein the proximal opening is located within the proximal chamber, thereby transferring the second liquid from the proximal chamber through the proximal opening and the inside of the transfer pipe to exit the distal end opening.

59. In the system described in claim 58, A system characterized in that, when the system is in the second injection configuration, the distal stopper member closes the intermediate opening.

60. In the system described in claim 53, The system is characterized in that the proximal and distal stopper members include first and second polymer coatings on their respective distal and proximal surfaces, and the proximal chamber is defined by the syringe body and the first and second polymer coatings.

61. In the system described in claim 53, The system is characterized in that the distal stopper member has a funnel that tapers in the proximal direction and a space located at the proximal end of the tapering funnel.

62. In the system described in claim 61, The system is characterized in that the funnel is configured to guide the proximal end of the transfer pipe into the space at the tapered proximal end of the funnel, thereby aligning the transfer pipe with the distal stopper member.

63. In the system described in claim 62, The system is characterized in that the funnel is configured to align the transfer pipe with the distal stopper member during the assembly of the system.

64. In the system described in claim 62, The system is characterized in that the funnel is configured to align the transfer pipe with the distal stopper member during the operation of the plunger member for inserting the proximal stopper member distally to the syringe body.

65. In the system described in claim 53, The system is characterized in that the distal stopper member has a detent that resists the passage of the proximal end of the transfer pipe.

66. In the system described in claim 65, The system is characterized in that the detent is configured such that a distal force of approximately 2 to 5 pounds applied to the plunger member overcomes the resistance to the passage of the proximal end of the transfer pipe.

67. In the system described in claim 66, A system characterized in that the detent is adjustable in order to adjust the distal force required to overcome resistance.

68. In the system described in claim 65, A system characterized in that the detent has a "U" shape.

69. In the system described in claim 65, The system is characterized in that the detent includes a bent wire.

70. In the system described in claim 65, The system is characterized in that the detent has a flattened cross-section.

71. In the system described in claim 65, The system is characterized in that the detent has a feature portion that accepts the proximal end of the transfer pipe.

72. In the system described in claim 71, The system is characterized in that the receiving feature portion at the proximal end of the transfer pipe has a chamfered surface.

73. In the system described in claim 65, The system is characterized in that the detent contains an annealed stainless steel alloy.

74. In the system described in claim 65, The system is characterized in that the proximal end of the transfer pipe includes a feature portion of the transfer pipe having an angle of approximately 30 degrees.

75. In the system described in claim 65, The system is characterized in that the transfer pipe has shoulders to resist the transfer pipe passing through the detent.

76. In the system described in claim 75, The system is characterized in that the shoulder portion and the detent are configured such that they overcome the resistance to the shoulder portion passing through the detent by a distal force of about 2 to 5 pounds applied to the plunger member.

77. In the system described in claim 76, A system characterized in that the detent is adjustable in order to adjust the distal force required to overcome resistance.

78. In the system described in claim 75, The system is characterized in that the shoulder portion has an angle of approximately 50 degrees.

79. In the system described in claim 65, The system is characterized in that the transfer pipe has grooves to resist the transfer pipe passing through the detent.

80. In the system described in claim 79, The system is characterized in that the groove and the detent are configured such that they overcome the resistance to the groove passing through the detent by a distal force of about 2 to 5 pounds applied to the plunger member.

81. In the system described in claim 80, A system characterized in that the detent is adjustable in order to adjust the distal force required to overcome resistance.

82. A method for continuously injecting a first liquid and a second liquid, A step of providing a system, wherein the system A syringe body that defines the proximal opening and distal end of the syringe, A proximal stopper member and a distal stopper member disposed on the syringe body, wherein a proximal chamber containing the second liquid is formed between the proximal stopper member and the distal stopper member, and a distal chamber containing the first liquid is formed between the distal stopper member and the distal end of the syringe body, A plunger member that defines the inside of the plunger and is configured to be manually operated to insert the proximal stopper member distally relative to the syringe body, A transfer pipe having an internal transfer pipe, a distal end opening, an intermediate opening, and a proximal opening, wherein the distal end opening, the intermediate opening, and the proximal opening are fluidly connected via the internal transfer pipe, The steps include a connector fluidly coupled inside the transfer pipe, The steps include: advancing the plunger member to discharge the first liquid from the distal chamber through the inside of the transfer pipe and the distal end opening; A method characterized by further advancing the plunger member to discharge the second liquid from the proximal chamber through the proximal opening, the inside of the transfer pipe, and the distal end opening.

83. In the method according to claim 82, The method further includes the step of connecting the coupling member to an IV bag before advancing the plunger member to discharge the first liquid from the distal chamber, thereby fluidly coupling the inside of the transfer pipe with the IV bag before discharging the first liquid.

84. In the method according to claim 83, A method further comprising the step of removing air from the distal chamber before connecting the coupling member to the IV bag.

85. In the method according to claim 84, The step of removing air from the distal chamber is, The steps include: holding the syringe body in a nearly vertical position; A method characterized by including the step of operating the plunger member to insert the proximal stopper member distally relative to the syringe body.

86. In the method according to claim 82, A method characterized by advancing the plunger member to insert the proximal stopper member distally relative to the syringe body, thereby applying a distal force through the second liquid to insert the distal stopper member distally relative to the syringe body, thereby discharging the first liquid from the distal chamber through the inside of the transfer pipe and the distal end opening.

87. In the method according to claim 82, The aforementioned system A first injection configuration in which the proximal opening is located in the distal chamber, The proximal opening is positioned in the proximal chamber, thereby enabling the transfer of the second liquid from the proximal chamber through the proximal opening and the inside of the transfer pipe to the outside of the distal end opening, The system is in the first injection configuration when the plunger member moves forward and discharges the first liquid from the distal chamber through the inside of the transfer pipe and the distal end opening. The system is characterized in that it is in the second injection configuration when the plunger member moves further forward to discharge the second liquid from the proximal chamber through the proximal opening, the inside of the transfer pipe, and the distal end opening.

88. In the method according to claim 87, A method characterized in that the distal stopper member closes the intermediate opening when the system is in the second injection configuration.

89. In the method according to claim 82, The distal stopper member is A funnel that tapers towards the proximal end, The funnel has a space located at its tapering proximal end, The method further includes the step of guiding the proximal end of the transfer pipe into the space at the tapered proximal end of the funnel, thereby aligning the proximal end of the transfer pipe with the distal stopper member.

90. In the method according to claim 82, The transfer pipe further has a proximal end, and the distal stopper member has a detent. The method further comprises the step of the detent resisting passage of the proximal end of the transfer pipe.

91. In the method of claim 90, A method characterized in that advancing the plunger member to discharge the first liquid from the distal chamber through the inside of the transfer pipe and the distal end opening includes applying a distal force to the plunger member to overcome the resistance to the proximal end of the transfer pipe passing through the detent.

92. In the method according to claim 91, A method characterized in that the distal force is approximately 2 pounds to approximately 5 pounds.

93. In the method according to claim 82, The transfer pipe further has a shoulder portion, and the distal stopper member has a detent. The method further comprises the step of the detent resisting the passage of the shoulder portion.

94. In the method according to claim 93, A method characterized in that further advancing the plunger member to discharge the second liquid from the proximal chamber through the proximal opening, the inside of the transfer pipe, and the distal end opening includes applying a distal force to the plunger member to overcome the resistance to the shoulder passing through the detent.

95. In the method of claim 94, A method characterized in that the distal force is approximately 2 pounds to approximately 5 pounds.

96. In the method according to claim 82, The transfer pipe further has a groove, and the distal stopper member has a detent. The method further comprises the step of the detent resisting passage through the groove.

97. In the method according to claim 96, A method characterized in that further advancing the plunger member to discharge the second liquid from the proximal chamber through the proximal opening, the inside of the transfer pipe, and the distal end opening includes applying a distal force to the plunger member to overcome the resistance to the groove passing through the detent.

98. In the method according to claim 97, A method characterized in that the distal force is approximately 2 pounds to approximately 5 pounds.

99. A system for mixing and injecting pharmaceutical products, A syringe body comprising a syringe body that defines the proximal opening of the syringe and the distal needle interface at the distal end, A proximal stopper member and a distal stopper member disposed on the syringe body, wherein a proximal chamber is formed between the proximal stopper member and the distal stopper member, and a distal chamber is formed between the distal stopper member and the distal end of the syringe body, A plunger member that defines the inside of the plunger and is configured to be manually operated to insert the proximal stopper member distally relative to the syringe body, The needle-holding feature portion arranged inside the plunger, An energy storage member disposed inside the plunger, A plunger member including an energy storage member latch member disposed inside the plunger, A needle hub assembly coupled to the distal needle interface of the syringe body, A needle having a characteristic portion at the proximal end, Hub and, The needle hub assembly includes a needle latch member configured to connect the needle to the hub, The distal stopper member includes a detent that resists the passage of the proximal end feature portion of the needle, A system characterized in that, in response to the relative operation of the plunger member with respect to the syringe body, the energy storage member latch member is converted from a latched state to an unlatched state, thereby allowing the needle to be retracted at least partially into the plunger.

100. In the system described in claim 99, The system is characterized in that the distal chamber has a vacuum inside.

101. A system for mixing and injecting pharmaceutical products, A syringe body comprising a syringe body that defines a proximal opening at the proximal end and a distal needle interface at the distal end, A proximal stopper member and a distal stopper member disposed on the syringe body, wherein a proximal drug chamber is formed between the proximal stopper member and the distal stopper member, and a distal drug chamber is formed between the distal stopper member and the distal end of the syringe body, A plunger member that defines the inside of the plunger and is configured to be manually operated to insert the proximal stopper member into the syringe body, A needle hub assembly coupled to the distal needle interface of the syringe body, A needle having a characteristic proximal end and a sharp distal end, A needle hub assembly including a hub, A needle cover comprising a needle cover having a threaded surface for removably connecting the needle cover to the hub, The system is characterized in that the needle cover has a sealing configuration that prevents the flow of fluid through the distal end of the needle, and a ventilation configuration that allows the flow of fluid through the distal end of the needle.

102. In the system according to claim 101, A system characterized in that the needle cover moves from the sealed configuration to the ventilated configuration by pulling the needle cover distally relative to the syringe body.

103. In the system according to claim 101, A system characterized in that the first and second sizes of the distal drug chamber and the proximal drug chamber, respectively, can be changed by the relative movement of the proximal and distal stopper members with respect to the syringe body.

104. In the system according to claim 101, The plunger member, The needle-holding feature portion arranged inside the plunger, An energy storage member disposed inside the plunger, The plunger includes an energy storage member latch member disposed inside the plunger, A system characterized in that, in response to the relative operation of the plunger member with respect to the syringe body, the energy storage member latch member is converted from a latched state to an unlatched state, thereby allowing the needle to be retracted at least partially into the plunger.

105. In the system according to claim 101, The system is characterized in that the needle assembly further includes a needle latch member configured to connect the needle to the hub.

106. In the system according to claim 101, The system is characterized in that the distal drug chamber and the proximal drug chamber each contain a first and second component of a drug that is mixed together before being injected into the patient.

107. In the system according to claim 101, The aforementioned system A transport configuration in which the proximal end feature portion of the needle is located within the distal drug chamber, The transfer configuration includes a needle proximal end feature portion that at least partially penetrates the distal stopper member and is at least partially positioned within the proximal drug chamber, A system characterized by having a mixing configuration in which the proximal stopper member and the distal stopper member come into contact with each other, thereby transferring a first drug component from the proximal drug chamber to the distal drug chamber, and mixing the first drug component with a second drug component in the distal drug chamber.

108. In the system described in claim 107, The aforementioned needle, The distal end opening located at the distal end of the needle, When the system is in transport configuration, transfer configuration and mixing configuration, an intermediate opening is located in the distal drug chamber, A system further comprising a proximal opening located in the proximal drug chamber when the system is in a transport configuration and a transfer configuration.

109. In the system described in claim 108, A system characterized in that the proximal opening is a slot.

110. In the system according to claim 101, The system is characterized in that the needle cover has a flexible finger configured to allow distal movement of the needle cover relative to the hub in the sealed configuration and to prevent distal movement of the needle cover relative to the hub in the ventilated configuration.

111. In the system described in claim 110, The system is characterized in that the hub has a threaded surface, which is configured to interact with the threaded surface of the needle cover and the flexible finger when the needle cover is in the ventilation configuration, thereby preventing distal movement of the needle cover relative to the syringe body without relative rotation of the needle cover relative to the syringe body.

112. In the system according to claim 101, A system characterized in that the needle cover transitions from the sealed configuration to the ventilated configuration by rotating the needle cover relative to the syringe body in a first direction.

113. In the system according to claim 112, The system is characterized in that the hub further comprises an interference member configured to detachably connect the needle cover to the hub.

114. In the system according to claim 101, A system characterized in that by moving the plunger member relatively distally to the syringe body, the distal stopper member moves relatively distally to the needle, and the proximal end feature portion of the needle penetrates the distal stopper member.

115. A system for mixing and injecting pharmaceutical products, A syringe body comprising a syringe body that defines a proximal opening at the proximal end and a distal needle interface at the distal end, A proximal stopper member and a distal stopper member disposed on the syringe body, wherein a proximal drug chamber is formed between the proximal stopper member and the distal stopper member, and a distal drug chamber is formed between the distal stopper member and the distal end of the syringe body, A plunger member that defines the inside of a plunger, wherein when the plunger member is rotated relative to the syringe body in a first direction, the plunger member advances and has a threaded surface that inserts the proximal stopper member into the syringe body, A needle hub assembly coupled to the distal needle interface of the syringe body, A needle having a characteristic proximal end and a sharp distal end, A needle hub assembly including a hub, The system is characterized by comprising a needle cover that is detachably coupled to the hub.

116. In the system described in claim 115, A system characterized in that the first and second sizes of the distal drug chamber and the proximal drug chamber, respectively, can be changed by the relative movement of the proximal and distal stopper members with respect to the syringe body.

117. In the system described in claim 115, The plunger member, The needle-holding feature portion arranged inside the plunger, An energy storage member disposed inside the plunger, The plunger includes an energy storage member latch member disposed inside the plunger, A system characterized in that, in response to the relative operation of the plunger member with respect to the syringe body, the energy storage member latch member is converted from a latched state to an unlatched state, thereby allowing the needle to be retracted at least partially into the plunger.

118. In the system described in claim 115, The system is characterized in that the needle assembly further includes a needle latch member configured to connect the needle to the hub.

119. In the system described in claim 115, The system is characterized in that the distal drug chamber and the proximal drug chamber each contain a first and second component of a drug that is mixed together before being injected into the patient.

120. In the system described in claim 115, The aforementioned system A transport configuration in which the proximal end feature portion of the needle is located within the distal drug chamber, The transfer configuration includes a needle proximal end feature portion that at least partially penetrates the distal stopper member and is at least partially positioned within the proximal drug chamber, A system characterized by having a mixing configuration in which the proximal stopper member and the distal stopper member come into contact with each other, thereby transferring a first drug component from the proximal drug chamber to the distal drug chamber, and mixing the first drug component with a second drug component in the distal drug chamber.

121. In the system according to claim 120, The aforementioned needle, The distal end opening located at the distal end of the needle, When the system is in the transport configuration, transfer configuration and mixing configuration, an intermediate opening is located in the distal drug chamber, A system further comprising a proximal opening located in the proximal drug chamber when the system is in the transport configuration and transfer configuration.

122. In the system according to claim 121, A system characterized in that the proximal opening is a slot.

123. In the system described in claim 115, The system is characterized in that the threaded surface of the plunger member has a double helix thread.

124. In the system described in claim 115, The system is characterized in that the threaded surface of the plunger member has threads with a relatively large pitch.

125. In the system according to claim 124, The system is characterized in that the threaded surface of the plunger member has a pitch of 8.5 mm.

126. In the system described in claim 115, The system is characterized in that the threaded surface of the plunger member is configured such that the plunger member can be advanced by rotating the plunger member relative to the syringe body in a first direction, thereby allowing the proximal stopper member to be inserted into the syringe body until the proximal stopper member contacts the distal stopper member.

127. In the system described in claim 115, The system is characterized in that the plunger member can be advanced by rotating the plunger member relative to the syringe body in a first direction, and the threaded surface of the plunger member is configured such that the proximal stopper member can be inserted into the syringe body until it is just before it contacts the distal stopper member.

128. In the system described in claim 115, A system further comprising a flange coupled to the proximal end of the syringe body, wherein the flange has a threaded surface, and this threaded surface interacts with the threaded surface of the plunger member to advance the plunger member as the plunger member rotates relative to the syringe body, thereby inserting the proximal stopper member into the syringe body.

129. In the system according to claim 128, The system is characterized in that the surface of the flange includes the removed wall.

130. In the system described in claim 115, A system characterized in that by rotating the plunger member in a first direction relative to the syringe body, the distal stopper member moves distally relative to the needle, so that the proximal end feature portion of the needle penetrates the distal stopper member.

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