HBV vaccine and methods of treating HBV

Abstract

This invention provides an HBV vaccine and a method for treating HBV. [Solution] A polypeptide useful for inducing a protective immune response to one or more hepatitis B virus (HBV) antigens in humans is provided. The immunogenic polypeptides described herein can induce prophylactic and / or therapeutic immune responses in humans to one or more hepatitis B virus (HBV) antigens. Generally, the immunogenic polypeptides described herein contain highly conserved portions of the HBV protein to induce a response to epitopes that are identical in vaccine antigens and in infectious HBV present in patients, while excluding poorly conserved regions, thereby avoiding the induction of an immune-dominant T cell response targeting epitopes that are not present in the patient's infectious HBV strain.

Claims

[Claim 1] The composition or method described in the specification.

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