Eye drops for inhibiting myopia progression in children and screening methods for myopia progression inhibitors in children

Abstract

The present invention provides a screening method for searching for components that inhibit the PERK pathway and / or the ATF6 pathway, and an active ingredient obtained by this screening method that inhibits myopia progression without inhibiting normal eye growth (emmetropization) in children, and provides eye drops and compositions containing the active ingredient. [Solution] The above problem is solved by an eye drop for inhibiting the progression of myopia in children that contains an inhibitor of the PERK (PKRK-like endoplasmic reticulum kinase) pathway and / or the ATF6 (Activating transcription factor 6) pathway as an active ingredient. The above problem is solved by a screening method for myopia progression inhibitors in children, which includes the steps of contacting a candidate substance with cells derived from the eye and selecting a candidate substance by indicating changes in the proteins and / or genes of the PERK and / or ATF6 signaling pathways in the cells.

Claims

1. An eye drop containing an inhibitor of the PERK (PKRK-like endoplasmic reticulum kinase) pathway and / or the ATF6 (Activating transcription factor 6) pathway as an active ingredient, which suppresses the increase in lens thickness that occurs with the progression of myopia in children aged 7 to under 15 years, wherein the inhibitor is at least one selected from the group consisting of phenylbutyric acid and its pharmacologically acceptable salts.

2. The eye drop according to claim 1, wherein the inhibitor is sodium phenylbutyrate.

3. The eye drop according to claim 1 or 2, wherein the content of the inhibitor is 0.01 to 5% by mass relative to the total amount of the eye drop.

4. The eye drop according to any one of claims 1 to 3, wherein the suppression of myopia progression in the child does not suppress physiological axial elongation.

5. The eye drop according to any one of claims 1 to 4, wherein the suppression of myopia progression in the child is due to the suppression of pathological axial elongation.

6. An eye drop according to any one of claims 1 to 5, which is used before a nap or before going to bed.

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