Heart valve prosthesis fixed by the interventricular septum

Abstract

This application relates to the field of medical devices, and in particular, to a cardiac valve prosthesis fixed by the interventricular septum. [Solution] The present invention relates to a heart valve prosthesis that is fixed by the interventricular septum, and comprises a valve stent 1 and a fixation device, the valve stent 1 comprising a valve suture segment and an artificial valve, the artificial valve being fixedly connected to the valve suture segment, and the fixation device comprising a fixation support segment 21 and a fixation member, one end of the fixation support segment 21 being connected to the proximal end portion of the valve suture segment and the other end being connected to the patient's interventricular septum by the fixation member, thereby supporting the heart valve prosthesis and restricting the axial movement of the heart valve prosthesis.

Description

【Technical Field】 【0001】 The present invention belongs to the field of medical devices, and specifically relates to a heart valve prosthesis fixed by an interventricular septum. 【Background Art】 【0002】 Conventional treatment means for mitral and tricuspid valve diseases include drug treatment applied to mild to severe regurgitation and surgical methods with corresponding surgical indications. Among them, surgical methods further include valve replacement surgery, valve repair surgery, etc. In surgical methods, typical thoracotomy and open heart surgery are too invasive and require the construction of extracorporeal circulation, with a high incidence of complications and infection risks. Many patients cannot withstand the huge surgical risks and can only wait for death helplessly. 【0003】 After the first report of aortic valve intervention replacement surgery, many companies have done a lot of work in the field of aortic valve intervention technology, so the technology is becoming increasingly mature. However, in the field of atrioventricular valve intervention treatment, there is still a large gap in the industry. At present, regarding the atrioventricular valve intervention treatment, a small number of products are used in transcatheter intervention valvuloplasty or repair, but in terms of transcatheter intervention valve replacement, internationally mature products have not yet appeared. 【0004】 Current clinical results indicate that there is no ideal product for interventional atrioventricular valve replacement. The main reason is that, whether it be the mitral valve or the tricuspid valve, they have unique physiological structures and a complex physiological environment beneath the annulus, making precise positioning and fixation of the product extremely difficult. Existing technical problems can be summarized as follows: (1) Current anchoring techniques rely mainly on the support of the atrioventricular annulus by the stent, and physicians often select and use valve specifications that are larger than the patient's own atrioventricular valve annulus to match the tissue contour of the mitral valve. In this way, the large stent itself not only affects the outflow tract but also easily compresses the surrounding tissue, further obstructing blood flow in the left ventricular outflow tract. (2) In current techniques, the stent portion located in the atrium is almost always in mesh form, and its large support easily compresses cardiac tissue. (3) Regarding mitral valve replacement, the stent specifications are too large, making it easy for the anterior leaflet of the mitral valve to be pushed into the left ventricular outflow tract. The leaflet clamping design introduced to fix the anterior leaflet of the mitral valve makes the release step very complicated and is affected by the degree of leaflet calcification, which affects the success rate of the surgery. (4) In the current fixation method that does not rely on radial force of the interventricular septum, the contact portion of the distal end of the fixation support segment with the patient's interventricular septum does not adhere tightly to the plane of the interventricular septum. As a result, anchoring by the fixation member fails, and if anchoring is forced, the stress is too great, which can damage the muscular tissue of the interventricular septum or cause the fixation member to be pulled out and detached. (5) Due to the presence of congenital leaflets, adaptive covered stents do not adhere tightly, and the artificial valve in which the atrioventricular valve membrane has been replaced experiences perivalvular leakage at the boundary of the congenital leaflets. (6) The dimensions and structure of the heart vary greatly among adults, children, and between Western and Eastern races. To achieve fixation by the interventricular septum, it is necessary to install very large European-spec fixation support segments, which results in high manufacturing and management costs. 【0005】 As described above, while each of the aforementioned surgeries has some effect in atrioventricular valve replacement, there are still shortcomings. Therefore, in the field of surgery to treat valvular lesions, there is an urgent need for new cardiac valve prostheses to solve the above problems. [Overview of the Initiative] [Problems that the invention aims to solve] 【0006】 In light of the above and many other ideas, I hereby submit this application. 【0007】 The present invention aims to overcome the limitations of the prior art and provide a cardiac valve prosthesis fixed by the interventricular septum for patients requiring interventional valve replacement due to mitral valve or tricuspid valve regurgitation or stenosis. The present invention solves the problems caused by radial expansion of the patient's own valve annulus in conventional anchoring techniques, ensuring the anchoring effect of the implanted valve, reducing the impact on the outflow tract after stent release, and avoiding stretching of the patient's own valve annulus. [Means for solving the problem] 【0008】 The objective of this invention is achieved by the following technical solution. 【0009】 A valve stent comprising a valve suture segment and an artificial valve fixedly connected to the valve suture segment, and a fixation device comprising a fixation support segment and a fixation member, wherein one end of the fixation support segment is connected to the proximal end portion of the valve suture segment and the other end is connected to the patient's interventricular septum by the fixation member, thereby fixing the valve prosthesis by the interventricular septum which supports the valve prosthesis and restricts its axial movement. 【0010】 The objectives of the present invention can be further realized by the following technical solutions. 【0011】 Preferably, the fixed support segment is provided with a curved segment such that its proximal end can be in close contact with the patient's interventricular septum. 【0012】 More preferably, the fixed support segment has a straight segment in the portion that contacts the patient's interventricular septum. 【0013】 Preferably, the fixed support segment is made of one or more rods / wires, each of which has one end connected to the valve suture segment and the other end provided with a portion that is combined with a fixing member, and is connected to the patient's interventricular septum via the fixing member. 【0014】 Preferably, in the circumferential arc where the outer edge of the valve sewing segment is located, the maximum arc length consisting of the connection points between the plurality of rods or wires and the valve sewing segment is one-quarter or more of the circumference of the valve sewing segment. 【0015】 Preferably, the fixed support segment is provided with a structure that is easily subjected to twisting deformation. 【0016】 Preferably, the structure that is prone to torsional deformation is a curved indentation structure. 【0017】 Preferably, the fixed support segment is provided with an extendable structure that allows for easy adjustment of its length. 【0018】 Preferably, the fixed support segment is formed by extending the skeletal structure at the proximal end of the valve suture segment. 【0019】 Preferably, the cardiac valve prosthesis further comprises an adaptive covered stent, the adaptive covered stent being connected to the valve suture segment, and in the free state, the adaptive covered stent is located within the patient's atrium. The adaptive covered stent has a circular portion at its distal end that is fixedly attached to the valve stent, a D-shaped portion in the middle, and an elliptical or nearly elliptical portion at its proximal end that contacts the atrial tissue. The self-expanding stent of the adaptive covered stent is integrally woven from wire material, and the coating of the self-expanding stent is a polymeric flexible material such as a PTFE membrane or a polyester membrane. 【0020】 Preferably, the above-mentioned heart valve prosthesis further comprises a leaflet lifting prevention device, and one end of the above-mentioned leaflet lifting prevention device is fixed to the valve membrane stent, and the other end is provided outside the valve membrane stent and / or the adaptive covered stent. 【0021】 Preferably, the installation position of the leaflet lifting prevention device corresponds to the connection location of its own leaflet. 【0022】 Preferably, the fixing member is an anchoring needle, and a position restricting member is provided at the tail of the anchoring needle. 【0023】 Preferably, in a cross-section perpendicular to the central axis of the artificial valve membrane, the valve membrane sewing segment has a cross-sectional area smaller than that of the patient's own valve membrane annulus so as not to radially expand the patient's own valve membrane annulus. 【0024】 Preferably, in the free state, the cross-sectional area of the adaptive covered stent is larger than that of the patient's own valve membrane annulus, and the adaptive covered stent can adapt to the uneven contour of the atrial wall or the patient's own valve membrane annulus without restricting the atrial contraction function. 【0025】 Preferably, in a cross-section perpendicular to the central axis of the artificial valve membrane, the center of the valve membrane sewing segment does not coincide with the center of the adaptive covered stent. 【0026】 Another object of the present invention is realized by the following technical solutions. 【0027】 a. The step of inserting a delivery catheter equipped with the above-mentioned heart valve prosthesis into the annulus location of the atrioventricular valve; b. The step of operating the delivery catheter to release the fixing device; c. The step of operating the delivery catheter to release the valve membrane sewing segment; d. operating the delivery catheter to insert the fixing member into the ventricular septum of the patient; e. pulling out the delivery catheter from the human body; A method used for the delivery and release of a heart valve prosthesis fixed by the ventricular septum as described above, which includes the above steps. 【0028】 Preferably, between step c and step d, c1. operating the delivery catheter to partially release the valve sewing segment so that the valve sewing segment is not completely detached from the delivery catheter; c2. operating the delivery catheter to release the adaptable covered stent and using the adaptable covered stent for positioning; c3. operating the delivery catheter to completely release the valve sewing segment, which are further included. 【Advantages of the Invention】 【0029】 Compared with the prior art, the advantages of the present invention are as follows. 【0030】 1. Different from the design in which most products in the prior art support the valve annulus with a stent, in the present invention, the fixed support segment is fixed to the ventricular septum of the patient by the fixing member. In such an anchoring method, the stent does not need to radially expand the patient's own valve annulus, and sufficient anchoring force can be obtained. 【0031】 2. Without employing radial support for the valve stent, and in a cross-section perpendicular to the central axis of the artificial valve, the projected area of ​​the valve suture segment is smaller than the projected area of ​​the patient's own valve annulus. Therefore, the valve suture segment does not radially expand the patient's own valve annulus. The fixed support segment connected to the valve suture segment is provided with a curved segment so that it can be in close contact with the patient's interventricular septum. As a result, the proximal end of the fixed support segment can be in close contact with the patient's interventricular septum, while the distal end of the fixed support segment, which is in contact with the patient's interventricular septum, is a straight segment. Such a design can maximize the contact area between the fixed support segment and the patient's interventricular septum and enhance the anchoring effect. 【0032】 3. In the present invention, the maximum arc length formed by the connection points between the plurality of rods and the valve sewing segment in the circumferential arc where the outer edge of the valve sewing segment is located is one-quarter or more of the circumference of the valve sewing segment. The advantage of this design is that the support points of the fixed support segment in the valve sewing segment can provide sufficient support strength and rigidity, and that tilting of the valve sewing segment is avoided. 【0033】 4. In the actual surgical process, after the valve stent is released, due to the significant differences in human cardiac structure, the contact portion of the distal end of the fixation support segment with the patient's interventricular septum often does not adhere tightly to the plane of the interventricular septum. If the fixation support segment is directly fixed with a fixation member, it becomes difficult to fix the fixation member to the interventricular septum, potentially leading to fixation failure. Even if the contact portion of the distal end of the fixation support segment with the patient's interventricular septum is forcibly fixed tightly to the interventricular septum, it may still fail. Furthermore, the maximum arc length of the fixation support segment, consisting of the connection points between the multiple rods or wires and the valve suture segment, is 4 / 4 of the circumference of the valve suture segment. Because the setting is set to be 1 or greater, the rigidity of the fixed support segment becomes too high. When the distal end of the fixed support segment is forcibly fixed to the patient's interventricular septum by the fixing member, the fixed support segment deforms to recover, applying a constant tensile force to the fixing member fixed to the interventricular septum. In addition, the pressure that the artificial heart valve receives during the heartbeat process is also applied to the fixing member. As a result, the fixing member is constantly pulling on the interventricular septum, and the muscle tissue of the patient's ventricular septum is constantly being damaged, leading to tissue damage. Consequently, the fixing member may be pulled out from the tissue of the ventricular septum, causing the valve stent to become unfixed and fail. In this invention, the fixed support segment is creatively provided with a structure that is easily twisted and deformed. Even if the contact portion of the distal end of the fixed support segment with the patient's interventricular septum does not adhere tightly to the plane of the interventricular septum, the fixed support segment can be deformed with only a small force. This avoids the risk of the fixing member failing to be fixed or being pulled off. Furthermore, due to the structure that is easily twisted and deformed (especially if the structure that is easily twisted and deformed is a curved inward recess structure), in this invention, the rigid connection between the valve stent and the fixation point becomes a semi-rigid connection with a certain buffering elasticity. When the artificial valve is subjected to pressure during ventricular contraction, the tensile and shear forces that the valve stent exerts on the fixation member are reduced, and the durability of the artificial valve is significantly increased. 【0034】 5. Unlike the prior art, the present invention provides a fixed support segment with a structure that is easily torsion-deformable, and on the premise that the anchoring point does not change, increases the actual length of the material of the fixed support segment, provides a larger adjustment range for the expandable structure that allows the length of the fixed support segment to be easily adjusted, and in addition provides a choice of cross-sectional diameters for the material of the fixed support segment, thereby making one specification of the heart valve prosthesis suitable for more patients and significantly reducing production and management costs. 【0035】 6. Unlike the prior art, the present invention is provided with multiple valve leaflet lifting prevention devices. These devices lift the valve leaflets and fix them together with the interventricular septum, providing multi-point support to the valve stent and ensuring uniform support for the valve stent. At the same time, the installation positions of the valve leaflet lifting prevention devices correspond to the connection points of their own valve leaflets, allowing the adaptive covered stent to fit more snugly to these connection points and reducing the occurrence of perialvalvular leakage at these points. 【0036】 7. Unlike the concentric structure of most conventional products, in the present invention, the center of the valve suture segment does not coincide with the center of the adaptive covered stent in a cross-section perpendicular to the central axis of the prosthetic valve. When the heart valve prosthesis is used for mitral valve interventional replacement, the central axis of the valve suture segment is biased towards the posterior leaflet region of the patient's mitral valve, which can further reduce obstruction to the left ventricular outflow tract. When the heart valve prosthesis is used for tricuspid valve interventional replacement, the central axis of the valve suture segment is biased towards the septal leaflet region of the patient's tricuspid valve, which is advantageous as the fixed support segment can tightly adhere to the target anchoring region, resulting in a more ideal anchoring effect and more stable valve movement. 【0037】 8. Unlike the design of most conventional stents that support the valve annulus, in the present invention, in a cross-section perpendicular to the central axis of the artificial valve, the projected area of ​​the valve suture segment is smaller than the projected area of ​​the patient's own valve annulus. Therefore, the valve suture segment does not radially expand the patient's own valve annulus, reducing the impact on the outflow tract after the stent is released and avoiding stretching of the original valve annulus. Furthermore, it ensures that the valve opening area does not change excessively due to large differences between patient valve annus, optimizing valve performance. At the same time, manufacturers can reduce product specifications, easing the pressure on manufacturers to prepare the goods. 【0038】 9. Most conventional stents located within the atrium employ a mesh design, which means their immense support force can easily compress cardiac tissue, and their leakage prevention effect is generally poor. The adaptive covered stent of the present invention, however, is located within the patient's atrium and is in close contact with the patient's own valve annulus, allowing it to adapt to the uneven contour of the atrial wall or the patient's own valve annulus, thereby improving the leakage prevention effect. 【0039】 Embodiments of this application can achieve other advantageous technical effects not listed herein, which may be described in later sections and should be anticipated and understood by those skilled in the art after reading this application. [Brief explanation of the drawing] 【0040】 By referring to the following description in conjunction with the drawings, the aforementioned features and advantages of these embodiments, other features and advantages, and the methods by which they are realized will become clearer, and the embodiments of this application will be better understood. 【0041】 [Figure 1] This is a schematic diagram of the overall structure of the heart valve prosthesis of the present invention. [Figure 2] This is a schematic diagram illustrating the connection between the valve suture segment and the fixed support segment of the present invention. [Figure 3]This diagram shows the implanted state of the heart valve prosthesis of the present invention within the heart. [Figure 4] This is a top view after the heart valve prosthesis of the present invention has been implanted, and the valve leaflet lift prevention device is located at the boundary of the valve leaflets. [Figure 5] This is another embodiment of the heart valve prosthesis of the present invention. [Figure 6-7] This is a schematic diagram showing what happens when twisting occurs in the curved recess structure of the present invention, where the valve suture segment does not move, but the curved recess structure rotates. [Figure 8-9] This is a schematic diagram of an expandable structure according to another embodiment of the present invention. [Modes for carrying out the invention] 【0042】 To make the purpose, technical proposal, and advantages of the present invention clearer and easier to understand, the present invention will be described in more detail below with reference to the drawings and examples. 【0043】 In this invention, the term "distal end" refers to the end far from the apex, and the term "proximal end" refers to the end close to the apex. 【0044】 Specific examples Example 1 As shown in Figures 1 and 2, a cardiac valve prosthesis fixed by the ventricular septum according to one embodiment of the present invention is illustrated, which comprises a valve stent 1 and a fixation device 2, the valve stent 1 comprising a valve suture segment 11 and an artificial valve 12, the artificial valve 12 being fixedly connected to the valve suture segment 11, and the fixation device 2 comprising a fixation support segment 21 and a fixation member 22, one end of the fixation support segment 21 being connected to the proximal end portion of the valve suture segment 11 and the other end being connected to the patient's ventricular septum by the fixation member 22, thereby supporting the cardiac valve prosthesis and restricting its axial movement. 【0045】 In this embodiment 1, as shown in Figure 2, a curved segment 211 is provided on the fixed support segment 21 so that the near end portion of the fixed support segment 21 can be in close contact with the patient's interventricular septum. 【0046】 In this embodiment 1, as shown in Figure 3, the fixed support segment 21 has a straight segment 212 in contact with the patient's interventricular septum. 【0047】 In this embodiment 1, the fixed support segment 21 is made of one or more rods / wires, each of which has one end connected to the valve suture segment 11 and the other end provided with a portion that is combined with a fixing member 22, and is connected to the patient's interventricular septum via the fixing member 22. 【0048】 In this embodiment 1, in the circumferential arc where the outer edge of the valve sewing segment 11 is located, the maximum arc length consisting of the connection points between the plurality of rods or wires and the valve sewing segment 11 is one-quarter or more of the circumference of the valve sewing segment 11. 【0049】 In this embodiment 1, the fixed support segment 21 is formed by extending the skeletal structure at the near end of the valve membrane sewing segment 11. 【0050】 In this embodiment 1, the cardiac valve prosthesis further comprises an adaptive covered stent 3, which is connected to the valve suture segment 11, and in the free state, the adaptive covered stent 3 is located in the patient's atrium. The adaptive covered stent 3 has a circular portion that is fixedly connected to the distal valve stent 1, a D-shaped portion in the middle, and an elliptical or nearly elliptical portion that contacts the atrial tissue at the proximal end. The self-expanding stent of the adaptive covered stent 3 is integrally woven from wire material, and the coating of the self-expanding stent is a polymeric flexible material such as a PTFE membrane or a polyester membrane. 【0051】 In this embodiment 1, the heart valve prosthesis further comprises a leaflet lift prevention device 4, one end of which is fixed to the valve stent 1 and the other end is provided outside the valve stent 1 and / or the adaptive covered stent 3. 【0052】 In this embodiment 1, as shown in Figure 4, the installation position of the valve leaflet lifting prevention device 4 corresponds to the connection point of its own valve leaflet. 【0053】 In this embodiment 1, the fixing member 22 is an anchoring needle, and a position regulating member is provided at the tail end of the anchoring needle. 【0054】 In this embodiment 1, in order that the valve suture segment 11 does not radially expand the patient's own valve annulus, the cross-sectional area of ​​the valve suture segment 11 is smaller than the cross-sectional area of ​​the patient's own valve annulus in a cross-section perpendicular to the central axis of the artificial valve 12. 【0055】 In this embodiment 1, in the free state, the cross-sectional area of ​​the adaptive covered stent 3 is larger than the cross-sectional area of ​​the patient's own valve annulus, and the adaptive covered stent 3 can adapt to the heterogeneous contour of the atrial wall or the patient's own valve annulus without restricting the atrial contractile function. 【0056】 In this embodiment 1, as shown in Figure 4, in a cross-section perpendicular to the central axis of the artificial valve 12, the center of the valve suture segment 11 does not coincide with the center of the adaptive covered stent 3. 【0057】 Example 2 Example 2 is almost the same as Example 1, but differs in that, as shown in Figure 5, the fixed support segment 21 is provided with a structure that is easily subjected to twisting deformation. 【0058】 This embodiment introduces a heart valve prosthesis fixed by the interventricular septum, comprising a valve stent 1 and a fixation device 2. The valve stent 1 comprises a valve suture segment 11 and an artificial valve 12, the artificial valve 12 being fixedly connected to the valve suture segment 11, and the fixation device 2 comprises a fixation support segment 21 and a fixation member 22. One end of the fixation support segment 21 is connected to the proximal end portion of the valve suture segment 11, and the other end is connected to the patient's interventricular septum by the fixation member 22, thereby supporting the heart valve prosthesis and restricting its axial movement. 【0059】 In this embodiment 2, as shown in Figures 6 and 7, the structure that is prone to torsional deformation is a curved indentation structure 213, and the curved indentation structure 213 is adapted to interventricular septa with different inclination bending angles. 【0060】 In this regard, the relevant structure and concept of Example 2 are similar to those of Example 1, so they will not be explained again here. 【0061】 Example 3 Example 3 is the same as Example 1, but differs in that the fixed support segment 21 is provided with an extendable structure 214 that allows for easy length adjustment. 【0062】 This embodiment introduces a heart valve prosthesis fixed by the interventricular septum, comprising a valve stent 1 and a fixation device 2. The valve stent 1 comprises a valve suture segment 11 and an artificial valve 12, the artificial valve 12 being fixedly connected to the valve suture segment 11, and the fixation device 2 comprises a fixation support segment 21 and a fixation member 22. One end of the fixation support segment 21 is connected to the proximal end portion of the valve suture segment 11, and the other end is connected to the patient's interventricular septum by the fixation member 22, thereby supporting the heart valve prosthesis and restricting its axial movement. 【0063】 In this embodiment 3, as shown in Figures 8 and 9, the expandable structure 214 provides a larger adjustment range for the fixed support segment 21, adjusting the distance between the anchoring region and the valve suture segment 11, thereby allowing one specification of the heart valve prosthesis to be adapted to more patients. 【0064】 In this regard, the relevant structure and concept of Example 3 are similar to those of Example 2, so they will not be explained again here. 【0065】 For illustrative purposes, a preamble describing several embodiments of the present application is provided, as described above. The preamble described herein is not intended to be an exhaustive list, nor to limit the present application to the specific configurations, structures, and / or steps disclosed, and it is clear that many modifications and variations are possible in accordance with the teachings of the preamble. The scope of the present invention and all its equivalents are intended to be limited by the appended claims. [Explanation of Symbols] 【0066】 1... Valve stent, 11... Valve suture segment, 12... Artificial valve, 2... Fixation device, 21... Fixation support segment, 211... Curved segment, 212... Straight segment, 213... Curved recessed structure, 214... Expandable structure, 22... Fixation member, 3... Adaptive covered stent, 4... Valve leaflet lift prevention device.

Claims

[Claim 1] A heart valve prosthesis fixed by the interventricular septum, A valve stent comprising a valve suture segment and an artificial valve fixedly connected to the valve suture segment, and a fixing device comprising a fixing support segment and a fixing member, wherein one end of the fixing support segment is connected to the proximal end portion of the valve suture segment and the other end is connected to the patient's interventricular septum by the fixing member, thereby supporting the heart valve prosthesis and restricting the axial movement of the heart valve prosthesis, characterized in that the heart valve prosthesis is fixed by the interventricular septum. [Claim 2] The ventricular valve prosthesis fixed by the ventricular septum according to claim 1, characterized in that the fixed support segment is provided with a curved segment such that its proximal end portion can be in close contact with the patient's interventricular septum. [Claim 3] The ventricular septum-fixed cardiac valve prosthesis according to claim 1, characterized in that the fixed support segment is made of one or more rods / wires, one end of each rod / wire is connected to the valve suture segment, and the other end is provided with a portion that is combined with the fixing member, and is connected to the patient's interventricular septum via the fixing member, and in the circumferential arc where the outer edge of the valve suture segment is located, the maximum arc length consisting of the connection points between the multiple rods or wires and the valve suture segment is one-quarter or more of the circumference of the valve suture segment. [Claim 4] The cardiac valve prosthesis fixed by the interventricular septum according to claim 1, characterized in that the fixed support segment is provided with a structure that is easily subjected to twisting deformation. [Claim 5] The aforementioned structure prone to twisting deformation is characterized by a curved inward recess structure, as described in claim 4, for a cardiac valve prosthesis fixed by the interventricular septum. [Claim 6] The cardiac valve prosthesis fixed by the interventricular septum according to claim 1 or 4, characterized in that the aforementioned fixed support segment is provided with an expandable structure that allows for easy adjustment of its length. [Claim 7] A cardiac valve prosthesis fixed by an interventricular septum according to claim 1, further comprising an adaptive covered stent. [Claim 8] A cardiac valve prosthesis fixed by the interventricular septum according to claim 7, further comprising a valve leaflet lifting prevention device. [Claim 9] The ventricular septum-fixed cardiac valve prosthesis according to claim 8, characterized in that one end of the valve leaflet lifting prevention device is fixed to the valve stent and the other end is provided on the outside of the valve stent and / or the adaptive covered stent, and the installation position of the valve leaflet lifting prevention device corresponds to the connection point of its own valve leaflets. [Claim 10] A cardiac valve prosthesis fixed by a ventricular septum according to claim 1, characterized in that, in a cross-section perpendicular to the central axis of the artificial valve, the cross-sectional area of ​​the valve suture segment is smaller than the cross-sectional area of ​​the patient's own valve annulus, so as not to radially expand the patient's own valve annulus.

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