Transdermal absorption patch

Abstract

The present invention provides a transdermal patch containing nicotine or a pharmaceutically acceptable salt thereof, and a method for manufacturing such a transdermal patch. [Solution] The transdermal patch comprises a backing layer, a first drug-containing adhesive layer containing a first nicotine or a pharmaceutically acceptable salt thereof and a first adhesive, a second drug-containing adhesive layer containing a second nicotine or a pharmaceutically acceptable salt thereof and a second adhesive, and a release liner, wherein the first drug-containing adhesive layer and the second drug-containing adhesive layer are positioned between the backing layer and the release liner.

Claims

1. It is a transdermal patch, Backing layer, A first drug-containing adhesive layer comprising a first nicotine or a pharmaceutically acceptable salt thereof and a first adhesive, A second drug-containing adhesive layer comprising a second nicotine or a pharmaceutically acceptable salt thereof and a second adhesive, Release liner and Equipped with, A transdermal absorption patch comprising the first drug-containing adhesive layer and the second drug-containing adhesive layer, positioned between the backing layer and the release liner.

2. The transdermal patch according to claim 1, wherein the thickness of the first drug-containing adhesive layer is in the range of 10 μm to 500 μm.

3. The transdermal patch according to claim 1, wherein the thickness of the second drug-containing adhesive layer is in the range of 10 μm to 500 μm.

4. The transdermal patch according to claim 1, wherein the content of the first nicotine or a pharmaceutically acceptable salt thereof is in the range of 5% to 30% by weight relative to the total weight of the first drug-containing adhesive layer, and the content of the second nicotine or a pharmaceutically acceptable salt thereof is in the range of 5% to 30% by weight relative to the total weight of the second drug-containing adhesive layer.

5. The transdermal patch according to claim 1, wherein the first adhesive and the second adhesive each include a pressure-sensitive adhesive.

6. The transdermal patch according to claim 5, wherein the pressure-sensitive adhesive is an acrylic pressure-sensitive adhesive.

7. The transdermal patch according to claim 1, wherein the first drug-containing adhesive layer or the second drug-containing adhesive layer further comprises an excipient.

8. The transdermal patch according to claim 7, wherein the first drug-containing adhesive layer contains a first excipient, the second drug-containing adhesive layer contains a second excipient, the content of the first excipient is in the range of 0.1% to 1% by weight relative to the total weight of the first drug-containing adhesive layer, and the content of the second excipient is in the range of 0.1% to 1% by weight relative to the total weight of the second drug-containing adhesive layer.

9. The transdermal patch according to claim 1, wherein the transdermal patch does not include a semipermeable paper or a semipermeable membrane.

10. A method for manufacturing a transdermal patch, the following: The steps include forming a first drug-containing adhesive layer on the backing layer and forming a second drug-containing adhesive layer on the release liner, A step of bonding the first drug-containing adhesive layer and the second drug-containing adhesive layer, wherein the first drug-containing adhesive layer and the second drug-containing adhesive layer are placed between the backing layer and the release liner, Equipped with, A method comprising: the first drug-containing adhesive layer comprising a first nicotine or a pharmaceutically acceptable salt thereof and a first adhesive; and the second drug-containing adhesive layer comprising a second nicotine or a pharmaceutically acceptable salt thereof and a second adhesive.

Images