Method for isolating T cells and T cell receptors for immunotherapy from tumors by single-cell analysis.
JP2026097840APending Publication Date: 2026-06-16THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
- Filing Date
- 2026-02-10
- Publication Date
- 2026-06-16
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Figure 2026097840000001_ABST
Abstract
This invention provides a method for preparing an enriched population of T cells that have antigen specificity for a target antigen. [Solution] The method may include isolating T cells from a patient's tumor sample; selecting isolated T cells having a gene expression profile; and separating the selected T cells from unselected cells. The isolated, selected T cells provide an enriched population of T cells having antigen specificity to a target antigen. Methods for isolating T cell receptors (TCRs), preparing populations of cells expressing TCRs, isolated TCRs, populations of isolated cells, pharmaceutical compositions, and methods for treating or preventing conditions in mammals are also provided.
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