Multi-cavity customizable dosage forms

Abstract

This invention provides a method for easily combining both active and inactive components into a single dosage form. [Solution] An improved customizable dosage form comprising a substrate such as a tablet core, having two or more distinct, isolated cavities on both sides of its outer surface and / or having two or more distinct, isolated cavities on a first side of its outer surface and an identifying feature portion on a second opposing side of its outer surface. A process for manufacturing such a customizable dosage form, wherein one or more active and inactive components, such as colorants, flavoring agents, and / or sensory agents, are deposited in at least one of the cavities.

Claims

1. A method for manufacturing a dosage form, (a) Preparing a substrate having two opposing surfaces and at least two cavities on a first surface, wherein the substrate contains at least one active ingredient. (b) Covering the substrate with a coating, (c) depositing a fluid material in at least one cavity, Methods that include...

2. A method for producing the dosage form according to claim 1, wherein the fluid material covers at least 50% of the bottom surface of the at least one cavity.

3. A method for producing the dosage form according to claim 1, wherein the fluid material covers at least 60% of the bottom surface of the at least one cavity.

4. A method for producing the dosage form according to claim 1, wherein the fluid material covers at least 70% of the bottom surface of at least one cavity.

5. The aforementioned fluid material is applied to the upper surface of the substrate by 30 mm. ２ A method for producing the dosage form described in claim 1, which diffuses in less than a certain amount.

6. The aforementioned fluid material is applied to the upper surface of the substrate by 20 mm ２ A method for producing the dosage form described in claim 1, which diffuses in less than a certain amount.

7. The fluid material is applied to the upper surface of the substrate by 10 mm ２ A method for producing the dosage form described in claim 1, which diffuses in less than a certain amount.

8. A method for producing the dosage form according to claim 1, wherein the fluid material comprises a polymer.

9. A method for producing the dosage form according to claim 8, wherein the polymer is a poloxamer.

10. A method for producing the dosage form according to claim 8, wherein the polymer is selected from hydroxypropyl methylcellulose, hydroxypropyl methylcellulose acetate succinate, and polyvinylpyrrolidone.

11. A method for producing the dosage form according to claim 8, wherein the polymer is a polyol.

12. A method for producing the dosage form according to claim 8, wherein the fluid material contains a maximum of 0.05 mL of an active or inactive component.

13. A method for producing a dosage form containing two mutually immiscible active ingredients, (a) Preparing a substrate having two opposing surfaces and at least two cavities on the first surface, wherein the substrate contains an active ingredient. (b) Covering the substrate with a coating, (c) Depositing a fluid material containing a second active ingredient in at least one cavity, Methods that include...

14. A method for producing a dosage form containing two mutually immiscible active ingredients, (a) Preparing a substrate having two opposing surfaces and at least two cavities on the first surface, (b) Covering the substrate with a coating, (c) Depositing a fluid material containing an active ingredient in at least one cavity, (d) depositing a fluid material containing a second active ingredient in at least one second cavity, Methods that include...

15. A method for producing a dosage form containing an active ingredient, (a) Preparing a substrate having two opposing surfaces and at least two cavities on the first surface, (b) Covering the substrate with a coating, (c) Depositing a first fluid material containing an active ingredient and a first polymer within the cavity, (d) Depositing a second fluid material containing the active ingredient and the second polymer in the cavity, Methods that include...

16. A method for producing the dosage form according to claim 15, wherein the first polymer is suitable for pH-dependent release of the active ingredient, and the second polymer is suitable for immediate release of the active ingredient.

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