Lipids suitable for nucleic acid delivery

Abstract

Providing a delivery platform suitable and efficient for the delivery of oligonucleotides. 【Solution means】Formula (I): TIFF2026098044000251.tif33161 A lipid having the structure of, wherein L is L a -X a -L b where; X a is selected from the group consisting of -O2C-, -CO2-L c -O2C-, L c -CO2-, -L c -O2C-, and -CO-NH-; L a is selected from the group consisting of C 4~20 alkylene, and C 0~4 alkylene; L b is selected from the group consisting of C 4~20 alkylene, and C 0~4 alkylene; L c is selected from the group consisting of C 1~6 alkylene-(O-C 1~6 alkylene) f -, and C 1~6 alkylene-S-S-C 1~6 alkylene, and C 1~4 alkylene; f is a lipid that is 0, 1, or 2.

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