Fluid component collection bladder and fluid collection loop

Abstract

To make the blood collection process more efficient and faster for donors. [Solution] Embodiments are described that include a device for separating components from blood. Embodiments include the separation of plasma from whole blood. Embodiments are also described that include a method and device for positioning a part of a disposable item, such as loops, within a medical device. Embodiments include the use of a surface for automatically guiding the loops to position them in a predetermined position.

Claims

1. A method for collecting blood components by apheresis, the method is The steps include drawing whole blood from the donor into a centrifuge, The steps include rotating the centrifuge to apply centrifugal force to the whole blood and separating the whole blood into at least a first blood component and a third blood component, A step of separating a first blood component from the whole blood, The first step of extracting the blood component into a container, A step to detect that a second blood component has been extracted, After the second blood component is detected, while the centrifuge continues to rotate, the separated first blood component is returned to the centrifuge, and at least the third blood component is moved from the centrifuge and returned to the donor. A method that includes this.

2. In the method described in claim 1, The first blood component is one or more of plasma, platelets, red blood cells, and / or high hematocrit blood. method.

3. In the method according to claim 1 or 2, The second blood component is one or more of plasma, platelets, red blood cells, and / or high-hematocrit blood, and the third blood component is one or more of plasma, platelets, red blood cells, and / or high-hematocrit blood. method.

4. In the method according to any one of claims 1 to 3, The first blood component is two or more of the following: plasma, platelets, red blood cells, and / or high hematocrit blood. method.

5. In the method according to any one of claims 1 to 4, The centrifuge rotates at a first speed when separating the first blood component from the whole blood. method.

6. In the method described in claim 5, The centrifuge continues to rotate at the first speed when returning the separated first blood component to the centrifuge. method.

7. In the method according to any one of claims 1 to 6, The centrifuge rotates at a second speed when drawing whole blood from the donor into the centrifuge. method.

8. In the method described in claim 7, The second speed is slower than the first speed. method.

9. In the method according to any one of claims 1 to 8, The first blood component is separated from the whole blood in a blood component collection set inserted into the centrifuge. method.

10. In the method described in claim 9, The centrifuge includes a filler that rotates a blood component collection bladder associated with the blood component collection set. method.

11. In the method according to claim 10, The blood component collection bladder is inserted into and held in the collection insertion channel formed in the filler. method.

12. In an apheresis system, A first tube having a lumen and being fluidly associated with a needle, and for moving whole blood from the donor through the lumen, A suction pump engaged with the first tube for drawing the whole blood into a centrifuge, A centrifuge that rotates to apply centrifugal force to the whole blood, thereby separating the whole blood into at least a first blood component and a third blood component, A blood component collection bladder is inserted into the centrifuge and is fluidly associated with the first tube, and separates the first blood component from the whole blood. A second tube is fluidly associated with the blood component collection bladder and moves the first blood component from the blood component collection bladder, A collection container is fluidly associated with the second tube and extracts the first blood component from the apheresis system, A sensor positioned in close proximity to the second tube and detecting that a second blood component has been extracted from the whole blood, A return pump engages with the second tube and, after the second blood component is detected by the sensor, while the centrifuge continues to rotate, returns the separated first blood component through the second tube to the blood component collection bladder and moves at least the third blood component from the blood component collection bladder back to the donor. An apheresis system equipped with the following features.

13. In the apheresis system according to claim 12, The first blood component is plasma, and the second blood component is platelets, red blood cells, and / or high hematocrit blood. Apheresis system.

14. In the apheresis system according to claim 12 or 13, The system further comprises an anticoagulant pump for drawing an anticoagulant from an anticoagulant bag and mixing the anticoagulant with whole blood in a manifold or junction fluidly associated with the first tube. Apheresis system.

15. In the apheresis system according to any one of claims 12 to 14, The centrifuge includes a filler that rotates the blood component collection bladder. Apheresis system.

16. In the apheresis system according to claim 15, The blood component collection bladder is inserted into and held in the collection insertion channel formed in the filler. Apheresis system.

17. A blood component collection set associated with an apheresis system, the set comprises: A needle is inserted into the donor's blood vessel to draw whole blood from the donor, A first tube having a lumen and being fluidly associated with the needle, and through which whole blood is moved, wherein a draw-in pump engaged with the first tube draws the whole blood from the donor, A blood component collection bladder is inserted into a centrifuge and is fluidly associated with the first tube, and separates a first blood component and a third blood component from the whole blood. A second tube is fluidly associated with the blood component collection bladder and moves the first blood component from the blood component collection bladder, A collection container for extracting the first blood component from the apheresis system, wherein a sensor is positioned physically close to the second tube to detect that the second blood component has been extracted from the whole blood, and after the second blood component has been detected by the sensor, a return pump engaged with the second tube returns the separated first blood component through the second tube to the blood component collection bladder, and moves at least the third blood component from the blood component collection bladder back to the donor, while the centrifuge continues to rotate. A blood component collection kit equipped with the necessary components.

18. In the blood component collection set according to claim 17, The first blood component is plasma, and the second blood component is platelets. Blood component collection kit.

19. In the blood component collection set according to claim 17 or 18, When the return pump returns the separated first blood component through the second tube to the blood component collection bladder and moves at least the third blood component from the blood component collection bladder back to the donor, the draw-in pump is disengaged. Blood component collection kit.

20. In the blood component collection set according to any one of claims 17 to 19, The blood component collection bladder is inserted into and held within a filler that rotates the blood component collection bladder in the centrifuge. Blood component collection kit.

21. An assembly for separating one component from a multi-component fluid, wherein the assembly is A filler having a channel for holding a separation bladder of a disposable product, wherein the channel has two opposing walls, A loop rotation positioning guide comprising multiple bearings, wherein the loop rotation positioning guide holds the flexible loop of a disposable item when the separation bladder is mounted in the channel, An assembly comprising:

22. In the assembly according to claim 21, The aforementioned loop rotation positioning guide includes a stopper plate. assembly.

23. In the assembly according to claim 21 or 22, The flexible loop contacts the stopper plate when it is held within the loop rotation positioning guide. assembly.

24. In the assembly according to any one of claims 21 to 23, The aforementioned assembly is part of an apheresis device. assembly.

25. In the assembly according to any one of claims 21 to 24, The assembly is connected to a rotor that rotates the loop rotation positioning guide around the axis of rotation. assembly.

26. In the assembly according to any one of claims 21 to 25, The aforementioned plurality of bearings comprises a plurality of pairs of roller bearings. assembly.

27. A centrifuge assembly, the centrifuge assembly is A centrifuge housing having an outer surface and an internal cavity, which rotates around the rotation axis of the centrifuge assembly, A fluid separation body is at least partially disposed within the internal cavity of the centrifugal separator housing and configured to rotate relative to the centrifugal separator housing about a rotation axis, A fluid line loop arm is attached to a part of the centrifugal separator housing and extends along the length of the outer surface of the centrifugal separator housing, Equipped with, The fluid line loop arm includes a set of bearings positioned at points along the length of the outer surface, The bearing set is configured to contact the tubular portion of the interconnected fluid line loops, holding the fluid line loops in an engaged position relative to the centrifugal separator housing, while allowing the fluid line loops to rotate in the engaged position. Centrifuge assembly.

28. In the centrifugal separator assembly according to claim 27, The bearing set comprises a pair of roller bearings, Centrifuge assembly.

29. In the centrifugal separator assembly according to claim 27 or 28, The bearing set comprises multiple pairs of roller bearings. Centrifuge assembly.

30. In the centrifugal separator assembly according to any one of claims 27 to 29, The aforementioned centrifuge assembly is part of an apheresis apparatus. Centrifuge assembly.

31. In the centrifugal separator assembly according to claim 30, The fluid line loop is attached at its first end to the fixed, non-rotating part of the apheresis device via a first positively-located connector, and at its second end, the fluid line loop is interconnected with the fluid separator body in the internal cavity via a second positively-located connector. Centrifuge assembly.

32. In the centrifugal separator assembly according to claim 31, The second end of the fluid line loop rotates together with the fluid separation body. Centrifuge assembly.

33. In the centrifugal separator assembly according to claim 31 or 32, The fluid line loop is physically and fluidly attached to a disposable fluid separation bladder with the second positive-movement positioning connector. Centrifuge assembly.

34. In the centrifugal separator assembly according to claim 33, The fluid line loop comprises a plurality of tubular lumens, and the fluid separation bladder comprises a first flexible sheet that is attached to a second flexible sheet to form a fluid path, wherein the first portion of the fluid path is narrower than the second portion of the fluid path. Centrifuge assembly.

35. A method for automatically mounting a fluid line loop to a centrifugal assembly, the method being The steps include attaching the fluid line loop to the fluid separation body of the centrifugal separator assembly at the first end, A step of rotating the fluid separation body in a first rotational direction relative to the housing of the centrifugal separator assembly, wherein by rotating the fluid separation body, the fluid line loop is rotated relative to the housing and guided to a channel of a loop arm attached to a part of the housing. Includes, The channel includes bearings positioned in a bearing set attached to the loop arm, the bearings holding the fluid line loop in place relative to the housing as the centrifuge assembly rotates, and the steps are: A method that includes this.

36. In the method described in claim 35, As the fluid line loop rotates within the channel relative to the housing at the predetermined position, the bearing comes into contact with a portion of the fluid line loop. method.

37. In the method according to claim 35 or 36, The centrifugal separator housing rotates in a first direction at a first angular velocity around the axis of rotation, and the fluid separation body is rotated at a different second angular velocity around the axis of rotation by the torsional force provided by the fluid line loop. method.

38. In the method described in claim 37, The second angular velocity is approximately twice the first angular velocity. method.

39. In the method according to any one of claims 35 to 38, The fluid line loop is physically and fluidly attached to a disposable fluid separation bladder that is at least partially located within the fluid separation body. method.

40. In the method according to any one of claims 35 to 39, The steps include attaching the second end of the fluid line loop to a point that is fixed in the rotational direction of the apheresis device, The steps include rotating the centrifugal separator assembly around the rotation axis with respect to a point fixed in the rotational direction of the apheresis apparatus via the rotor motor assembly of the apheresis apparatus, A method that further includes this.

41. A filler for holding a separation bladder from which components are separated from a composite fluid, The aforementioned filler is, The system includes a channel for holding a separation bladder during the separation of components from the composite fluid, The aforementioned channel is The first obstacle, The second wall opposite the first wall, Equipped with, The first end of the channel is adjacent to the center of the filler, and the channel is spiral in shape toward the outer circumference of the filler. Filler.

42. In the filler according to claim 41, The upper end of the channel is narrower than the central part of the channel. Filler.

43. In the filler according to claim 41 or 42, At least a portion of the second wall has a concave surface, Filler.

44. In the filler according to any one of claims 41 to 43, The second end of the channel is positioned to experience a higher gravitational force than the first end during separation. Filler.

45. In the filler according to any one of claims 41 to 44, The upper end of the channel provides reinforcement to the separation bladder during separation. Filler.

46. A fluid separation filler, wherein the filler is A main body having a rotation axis positioned approximately at the center of mass of the main body, A fluid collection and insertion channel is disposed within the main body and follows a substantially spiral path extending outward in a spiral manner from a first point near the rotation axis to a second point located near the outer circumference of the main body, Equipped with The fluid collection and insertion channel curves outward toward the circumferential portion of the body near the end of the substantially helical path defining the third point of the fluid collection and insertion channel that is located furthest from the axis of rotation, Fluid separation filler.

47. In the fluid separation filler according to claim 46, The device further comprises a fluid collection chamber disposed within the main body and following a portion of the substantially spiral path, and the fluid collection insertion channel is connected to the fluid collection chamber and defines an access area between the inside of the fluid collection chamber and the outside of the main body. Fluid separation filler.

48. In the fluid separation filler according to claim 47, The fluid collection chamber is configured to receive a disposable fluid collection bladder. Fluid separation filler.

49. In the fluid separation filler according to any one of claims 46 to 48, The distance from the rotation axis to the third point of the substantially helical path is greater than the distance from the rotation axis to the second point of the substantially helical path. Fluid separation filler.

50. In the fluid separation filler according to any one of claims 46 to 49, The width of the fluid collection chamber at a point along the substantially helical path is greater than the width of the fluid collection insertion channel at the point along the substantially helical path. Fluid separation filler.

51. In the fluid separation filler according to claim 47 or 48, The fluid collection chamber further comprises a first wall that follows the innermost portion of the substantially helical path, and a second wall that is substantially parallel to the first wall and follows the outermost portion of the substantially helical path. Fluid separation filler.

52. In the fluid separation filler according to claim 51, The fluid collection chamber further comprises one or more tapered walls positioned between the first wall and the second wall, the one or more tapered walls being configured to guide the disposable fluid collection bladder to a seated position within the fluid collection chamber. Fluid separation filler.

53. In the fluid separation filler according to claim 52, The fluid inlet for the disposable fluid collection bladder, when installed in the fluid collection chamber, is located adjacent to the rotating shaft, and the first fluid path of the disposable fluid collection bladder follows the substantially spiral path outward toward the end of the disposable fluid collection bladder located adjacent to the third point of the fluid collection insertion channel located furthest from the rotating shaft, and is fluidically interconnected with a second fluid path that is separated from the first fluid path of the disposable fluid collection bladder and extends inward from the third point along the substantially spiral path toward the fluid outlet for the disposable fluid collection bladder located adjacent to the rotating shaft. Fluid separation filler.

54. In the fluid separation filler according to claim 53, The fluid inlet and the fluid outlet are part of a connector attached to the disposable fluid collection bladder, and the body of the fluid separator filler includes a connection point that engages with the connector. Fluid separation filler.

55. In the fluid separation filler according to claim 54, The connector includes at least one key function portion, the connection point includes at least one mating key function portion, and the key function portion securely positions the connector with respect to the connection point. Fluid separation filler.

56. A centrifuge assembly, the centrifuge assembly is A centrifuge housing having an internal cavity and rotating around the rotation axis of the centrifuge assembly, A fluid separation body is at least partially disposed within the internal cavity of the centrifugal separator housing and configured to rotate relative to the centrifugal separator housing about a rotation axis, Equipped with, The fluid separation body includes a fluid collection and insertion channel that is disposed within the fluid separation body and follows a substantially spiral path extending outward in a spiral manner from a first point adjacent to the rotation axis to a second point located adjacent to the outer circumference of the fluid separation body. The fluid collection and insertion channel curves outward toward the outer circumference of the main body near the end of the substantially helical path that defines the third point of the fluid collection and insertion channel located furthest from the axis of rotation, Centrifuge assembly.

57. In the centrifugal separator assembly according to claim 56, The fluid separation body further comprises a fluid collection chamber disposed within the body and following a portion of the substantially spiral path, and the fluid collection insertion channel is connected to the fluid collection chamber and defines an access area between the inside of the fluid collection chamber and the outside of the fluid separation body. Centrifuge assembly.

58. In the centrifugal separator assembly according to claim 57, The system further comprises a disposable fluid collection bladder disposed within the fluid collection chamber and following the substantially spiral path, the disposable fluid collection bladder including a fluid inlet located adjacent to the rotation axis, the first fluid path of the disposable fluid collection bladder following the substantially spiral path outward toward the end of the disposable fluid collection bladder located adjacent to the third point of the fluid collection insertion channel located furthest from the rotation axis, and is fluidically interconnected with a second fluid path separated from the first fluid path of the disposable fluid collection bladder and extending inward from the third point along the substantially spiral path toward a fluid outlet for the disposable fluid collection bladder located adjacent to the rotation axis. Centrifuge assembly.

59. In the centrifugal separator assembly according to any one of claims 56 to 58, The aforementioned centrifuge assembly is part of an apheresis apparatus. Centrifuge assembly.

60. In the centrifugal separator assembly according to any one of claims 56 to 59, The centrifugal separator housing is divided into an upper housing and a lower housing, the upper housing includes an internal cavity, the upper housing is rotatable between an open state and a closed state about a pivot axis offset from the rotation axis and substantially perpendicular to the rotation axis, the fluid collection insertion channel of the fluid separation body is accessible in the open state and inaccessible in the closed state. Centrifuge assembly.

61. A blood component collection loop, the blood component collection loop is Flexible loops and A system fixed loop connector is positioned at the first end of the flexible loop, and the system fixed loop connector is connected to the fixed loop connection portion of the centrifuge so as to fix the first end of the flexible loop so as to rotate integrally with the centrifuge. A filler loop connector is positioned at a second end of the flexible loop opposite to the first end, wherein the filler loop connector is connected to the loop connection region of the filler, and a torsional force based on twisting in the flexible loop is applied to the filler via the filler loop connector. Equipped with, The flexible loop is moved in the rotational direction so as to be captured by a loop rotation positioning guide located in the centrifuge. Blood component collection loop.

62. In the blood component collection loop according to claim 61, The aforementioned blood component collection loop is part of a blood component collection set, and the blood component collection set is associated with an apheresis system. Blood component collection loop.

63. In the blood component collection loop according to claim 61 or 62, The loop rotation positioning guide is attached to a rotor that rotates the loop rotation positioning guide and the flexible loop around the axis of rotation. Blood component collection loop.

64. In the blood component collection loop according to any one of claims 61 to 63, The blood component collection loop is at least partially positioned by a loop positioning stopper plate. Blood component collection loop.

65. In the blood component collection loop according to any one of claims 61 to 64, The flexible loop is curved around the centrifuge. Blood component collection loop.

66. In the blood component collection loop according to any one of claims 61 to 65, The flexible loop is also held in a predetermined position by the loop storage bracket. Blood component collection loop.

67. In the blood component collection loop according to any one of claims 61 to 66, At least a portion of the loop rotation positioning guide is equipped with a loop torsion support bearing. Blood component collection loop.

68. In the blood component collection loop according to claim 67, The aforementioned loop torsion support bearing comprises a pair of roller bearings. Blood component collection loop.

69. In the blood component collection loop according to claim 68, The loop torsion support bearing allows the flexible loop to twist. Blood component collection loop.

70. In the blood component collection loop according to claim 69, The twisting causes the filler to rotate at an angular velocity greater than that of the centrifugal separator. Blood component collection loop.

71. In the blood component collection loop according to any one of claims 61 to 70, The flexible loop may include two or more lumens for moving whole blood and / or blood components within the flexible loop. Blood component collection loop.

72. The first port and The second port and A DC tubular lumen fluidly connected to the first port and the second port, A drip chamber, wherein the drip chamber is positioned within the DC tube lumen such that the fluid passing through the DC tube lumen passes through the drip chamber, A fluid flow bypass path, wherein the fluid flowing through the fluid flow bypass path bypasses the drip chamber, and is fluid-connected to the DC lumen adjacent to the first port between the first port and the drip chamber, and is fluid-connected to the DC lumen adjacent to the second port between the second port and the drip chamber, A soft cartridge equipped with [features / equipment].

73. In the soft cassette according to claim 72, The fluid flow bypass path comprises a first bypass branch adjacent to the first port and fluidly connected to the DC lumen, and a second bypass branch adjacent to the second port and fluidly connected to the DC lumen. Soft cassette.

74. In the soft cassette according to claim 73, The fluid flow bypass path further comprises a fluid pressure ring positioned between the first bypass branch and the second bypass branch and fluidly connected to these bypass branches. Soft cassette.

75. In the soft cassette according to claim 74, The DC tubular lumen includes a first flexible region positioned between the first connection point with the first bypass branch and the drip chamber, the first flexible region being such that the first fluid control valve can close the DC tubular lumen. Soft cassette.

76. In the soft cassette according to claim 75, The DC tubular lumen includes a second flexible region positioned between the second connection point with the second bypass branch and the drip chamber, the second flexible region enabling the second fluid control valve to close the DC tubular lumen. Soft cassette.

77. In the soft cassette according to claim 76, The DC pipe lumen includes a third flexible region located within the first bypass branch, the third flexible region enabling the intake fluid control valve to close the first bypass branch. Soft cassette.

78. In the soft cassette according to claim 77, The first port is fluid-connected to a cassette inlet tube that moves fluid from the donor to the soft cassette or from the soft cassette to the donor, and the second port is fluid-connected to a loop inlet tube that moves fluid from the soft cassette to the centrifuge or from the centrifuge to the soft cassette. Soft cassette.

79. In a soft cassette according to any one of claims 72 to 78, When the fluid is drawn in from the donor, the fluid passes through the fluid flow bypass path. Soft cassette.

80. In a soft cassette according to any one of claims 72 to 79, When the fluid is sent to the donor, the fluid passes through the DC tube lumen. Soft cassette.

81. In the soft cassette according to claim 80, When the fluid is drawn from the donor in the next draw-in, a portion of the fluid previously sent to the donor through the DC lumen is retained in the drip chamber as the fluid passes through the fluid flow bypass path. Soft cassette.

82. In a soft cassette according to any one of claims 72 to 81, The aforementioned soft cassette is part of a blood component collection set. Soft cassette.

83. In the soft cassette according to claim 82, The aforementioned blood component collection set is part of the apheresis system. Soft cassette.

84. A blood component collection kit, the blood component collection kit is A centrifuge for separating blood components from whole blood, A cassette inlet tube that is connected to the donor fluid, A loop inlet tube connected to the centrifuge, Soft cartridge and Equipped with, The aforementioned soft cassette is A first cassette port is fluid-connected to the cassette inlet tube, A second cassette port is fluid-connected to the loop inlet tube, A DC tubular lumen is fluidly connected to the first cassette port and the second cassette port, A drip chamber, wherein the drip chamber is positioned within the DC tube lumen such that the fluid passing through the DC tube lumen passes through the drip chamber, A fluid flow bypass path, wherein the fluid flowing through the fluid flow bypass path bypasses the drip chamber, and is fluid-connected to the DC lumen adjacent to the first cassette port between the first cassette port and the drip chamber, and is fluid-connected to the DC lumen adjacent to the second cassette port between the second cassette port and the drip chamber, Equipped with, Blood component collection kit.

85. In the blood component collection set according to claim 84, The aforementioned fluid flow bypass path is A first bypass branch section adjacent to the first cassette port and fluidly connected to the DC tube lumen, A second bypass branch section adjacent to the second cassette port and fluidly connected to the DC tube lumen, A fluid pressure ring is positioned between the first bypass branch and the second bypass branch and is fluidly connected to these bypass branches, Equipped with, Blood component collection kit.

86. In the blood component collection set according to claim 85, The DC tubular lumen includes a first flexible region located between a first connection to the first bypass branch and the drip chamber, the first flexible region enabling a first fluid control valve to close the DC tubular lumen; the DC tubular lumen includes a second flexible region located between a second connection to the second bypass branch and the drip chamber, the second flexible region enabling a second fluid control valve to close the DC tubular lumen; and the DC tubular lumen includes a third flexible region located within the first bypass branch, the third flexible region enabling a draw-in fluid control valve to close the first bypass branch. Blood component collection kit.

87. In the blood component collection set according to claim 86, When drawing fluid from the donor, The first fluid control valve and the second fluid control valve are closed to block the DC pipe lumen. The intake fluid control valve is opened to allow whole blood to pass through the fluid flow bypass path. Blood component collection kit.

88. In the blood component collection set according to claim 86 or 87, When sending the fluid to the donor, The first fluid control valve and the second fluid control valve are opened to allow the fluid to pass through the DC pipe lumen. The aforementioned intake fluid control valve is closed to block the fluid flow bypass path. Blood component collection kit.

89. In the blood component collection set according to claim 88, When the fluid is drawn from the donor in the next draw-in, a portion of the fluid previously sent to the donor through the DC lumen is retained in the drip chamber as the fluid passes through the fluid flow bypass path. Blood component collection kit.

90. In a method for moving a fluid through a soft cassette, the method is: The step of preparing a soft cassette, wherein the soft cassette is A first cassette port is fluid-connected to the cassette inlet tube, A second cassette port is connected to the loop inlet tube for fluid, A DC tubular lumen is fluidly connected to the first cassette port and the second cassette port, A drip chamber comprising drip chambers arranged relative to each other within the DC tubular lumen such that the fluid passing through the DC tubular lumen passes through the drip chambers, A fluid flow bypass path, wherein the fluid flowing through the fluid flow bypass path bypasses the drip chamber, and is fluid-connected to the DC lumen adjacent to the first cassette port between the first cassette port and the drip chamber, and is fluid-connected to the DC lumen adjacent to the second cassette port between the second cassette port and the drip chamber, It has steps, The method is, When drawing whole blood from a donor, The steps include receiving whole blood from the cassette inlet tube at a first cassette port that is fluidly connected to the cassette inlet tube, The steps include moving the whole blood to the second cassette port through the fluid flow bypass path, A step to prevent whole blood from moving through the straight-line lumen, It has, The method is, When returning red blood cells to the donor, The steps include receiving red blood cells from the loop inlet tube at a second cassette port that is fluidly connected to the loop inlet tube, The steps include moving the red blood cells to the first cassette port through the DC lumen and the drip chamber, A step of preventing red blood cells from moving through the fluid flow bypass path, Having, method.

91. In the method described in claim 90, When fluid is drawn from the donor in the next draw-in, a portion of the fluid previously sent to the donor through the DC lumen is retained in the drip chamber as the whole blood passes through the fluid flow bypass path again when the red blood cells are returned to the donor. method.

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