Bicyclic amines as CDK2 inhibitors

Abstract

We provide a CDK inhibitor that targets CDK2. [Solution] Formula (a10): JPEG2026102714000238.jpg3472 A method for producing a compound of or a pharmaceutically acceptable salt thereof, wherein formula (a9): JPEG2026102714000239.jpg2862 The method comprising reacting a compound or a salt thereof with methanesulfonyl chloride in the presence of a base to form a compound of formula (a10) or a pharmaceutically acceptable salt thereof.

Claims

1. Compound of formula (I), 【Chemistry 1】 or a pharmaceutically acceptable salt thereof, in the formula, n is 0, 1, 2, 3, or 4, p is 0, 1, 2, 3, or 4, 【Chemistry 2】 However, it is either a single bond or a double bond. X is N, Y is C, and the ring 【Transformation 3】 but, 【Chemistry 4】 is, or X is C, Y is N, and the ring 【Transformation 5】 but, 【Transformation 6】 And, Z is CR ２ or N, Ring portion A is C ３－１０ Selected from cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, and 5-10 membered heteroaryl, Ring portion B is a 4- to 10-membered heterocycloalkyl group, where ring portion B is bonded to the -NH- group of formula (I) by a ring member of the saturated or partially unsaturated ring of the 4- to 10-membered heterocycloalkyl group. R １ is independently H, D, halo, CN, NO ２ , C １－６ alkyl, C ２－６ alkenyl, C ２－６ alkynyl, C １－６ haloalkyl, C ３－１０ cycloalkyl, 6-10 member aryl, 4-10 member heterocycloalkyl, 5-10 member heteroaryl, C ３－１０ cycloalkyl-C １－４ alkyl, 6-10 member aryl-C １－４ alkyl, 4-10 member heterocycloalkyl-C １－４ alkyl, 5-10 member heteroaryl-C １－４ alkyl, OR ａ１ , SR ａ１ , NHOR ａ１ , C(O)R ｂ１ , C(O)NR ｃ１ R ｄ１ , C(O)NR ｃ１ (OR ａ１ ), C(O)OR ａ１ , OC(O)R ｂ１ , OC(O)NR ｃ１ R ｄ１ , NR ｃ１ R ｄ１ , NR ｃ１ NR ｃ１ R ｄ１ , NR ｃ１ C(O)R ｂ１ , NR ｃ１ C(O)OR ａ１ , NR ｃ１ C(O)NR ｃ１ R ｄ１ , C(=NR ｅ１ )R ｂ１ , C(=NR ｅ１ )NR ｃ１ R ｄ１ , NR ｃ１ C(=NR ｅ１ )NR ｃ１ R ｄ１ , NR ｃ１ C(=NR ｅ１ )R ｂ１ , NR ｃ１ S(O)NR ｃ１ R ｄ１ , NR ｃ１ S(O)R ｂ１ , NR ｃ１ S(O) ２ R ｂ１ , NR ｃ１ S(O)(=NR ｅ１ )R ｂ１ , NR ｃ１ S(O) ２ NR ｃ１ R ｄ１ , S(O)R ｂ１ , S(O)NR ｃ１ R ｄ１ , S(O) ２ R ｂ１ , S(O) ２ NR ｃ１ R ｄ１ , OS(O)(=NR ｅ１ )R ｂ１ , OS(O) ２ R ｂ１ , S(O)(=NR ｅ１ )R ｂ１ , SF ５ , P(O)R ｆ１ R ｇ１ , OP(O)(OR ｈ１ )(OR ｉ１ ), P(O)(OR ｈ１ )(OR ｉ１ ), and BR ｊ１ R ｋ１ selected from, wherein the C １－６ alkyl, C ２－６ alkenyl, C ２－６ alkynyl, C １－６ haloalkyl, C ３－１０ cycloalkyl, 6-10 member aryl, 4-10 member heterocycloalkyl, 5-10 member heteroaryl, C ３－１０ cycloalkyl-C １－４ alkyl, 6-10 member aryl-C １－４ alkyl, 4-10 member heterocycloalkyl-C １－４ alkyl, and 5-10 member heteroaryl-C １－４ alkyl are each optionally, independently selected, substituted with 1, 2, 3, or 4 R １Ａ substituents, Each R ａ１ , R ｃ１ , and R ｄ１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. １Ａ Substituting with substituents, Alternatively, any R bonded to the same N atom ｃ１ and R ｄ１ However, together with the N atom to which they are bonded, they form a 4- to 10-membered heterocycloalkyl group, and the 4- to 10-membered heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. １Ａ Substituting with substituents, Each R ｂ１ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. １Ａ Substituting with substituents, Each R ｅ１ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ１ and R ｇ１ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ１ and R ｉ１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｊ１ and R ｋ１ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ１ and R ｋ１ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A five-membered or six-membered heterocycloalkyl group is formed, which is optionally substituted with one, two, three, or four substituents independently selected from the haloalkyl group. Each R １Ａ These are independent: H, D, Halo, CN, NO ２ , C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl, 5-6 member heteroaryl-C １－４ Alkyl, OR ａ１１ , SR ａ１１ , NHOR ａ１１ , C(O)R ｂ１１ C(O)NR ｃ１１ R ｄ１１ C(O)NR ｃ１１ (OR ａ１１ ), C(O)OR ａ１１ OC(O)R ｂ１１ , OC(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ R ｄ１１ , NR ｃ１１ NR ｃ１１ R ｄ１１ , NR ｃ１１ C(O)R ｂ１１ , NR ｃ１１ C(O)OR ａ１１ , NR ｃ１１ C(O)NR ｃ１１ R ｄ１１ , C(=NR ｅ１１ ) R ｂ１１ , C(=NR ｅ１１ ) NR ｃ１１ R ｄ１１ , NR ｃ１１ C (=NR ｅ１１ ) NR ｃ１１ R ｄ１１ , NR ｃ１１ C (=NR ｅ１１ ) R ｂ１１ , NR ｃ１１ S(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ S(O)R ｂ１１ , NR ｃ１１ S(O) ２ R ｂ１１ , NR ｃ１１ S(O)(=NR ｅ１１ ) R ｂ１１ , NR ｃ１１ S(O) ２ NR ｃ１１ R ｄ１１ S(O)R ｂ１１ S(O)NR ｃ１１ R ｄ１１ , S(O) ２ R ｂ１１ , S(O) ２ NR ｃ１１ R ｄ１１ , OS(O)(=NR ｅ１１ ) R ｂ１１ OS(O) ２ R ｂ１１ , S(O)(=NR ｅ１１ ) R ｂ１１ SF ５ P(O)R ｆ１１ R ｇ１１ , OP(O)(OR ｈ１１ ) ( OR ｉ１１ ), P(O)(OR ｈ１１ ) ( OR ｉ１１ ), and BR ｊ１１ R ｋ１１ Selected from, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. １Ｂ Substituting with substituents, Each R ａ１１ , R ｃ１１ , and R ｄ１１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. １Ｂ Substituting with substituents, Alternatively, any R bonded to the same N atom ｃ１１ and R ｄ１１ However, together with the N atom to which they are bonded, they form a 4-7 member heterocycloalkyl group, and the 4-7 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. １Ｂ Substituting with substituents, Each R ｂ１１ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. １Ｂ Substituting with substituents, Each R ｅ１１ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ１１ and R ｇ１１ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ１１ and R ｉ１１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｊ１１ and R ｋ１１ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ１１ and R ｋ１１ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A five-membered or six-membered heterocycloalkyl group is formed, which is optionally substituted with one, two, three, or four substituents independently selected from the haloalkyl group. Each R １Ｂ These are independent: H, D, Halo, CN, NO ２ , C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl, 5-6 member heteroaryl-C １－４ Alkyl, OR ａ１２ , SR ａ１２ , NHOR ａ１２ , C(O)R ｂ１２ C(O)NR ｃ１２ R ｄ１２ C(O)NR ｃ１２ (OR ａ１２ ), C(O)OR ａ１２ OC(O)R ｂ１２ , OC(O)NR ｃ１２ R ｄ１２ , NR ｃ１２ R ｄ１２ , NR ｃ１２ NR ｃ１２ R ｄ１２ , NR ｃ１２ C(O)R ｂ１２ , NR ｃ１２ C(O)OR ａ１２ , NR ｃ１２ C(O)NR ｃ１２ R ｄ１２ , C(=NR ｅ１２ ) R ｂ１２ , C(=NR ｅ１２ ) NR ｃ１２ R ｄ１２ , NR ｃ１２ C (=NR ｅ１２ ) NR ｃ１２ R ｄ１２ , NR ｃ１２ C (=NR ｅ１２ ) R ｂ１２ , NR ｃ１２ S(O)NR ｃ１２ R ｄ１２ , NR ｃ１２ S(O)R ｂ１２ , NR ｃ１２ S(O) ２ R ｂ１２ , NR ｃ１２ S(O)(=NR ｅ１２ ) R ｂ１２ , NR ｃ１２ S(O) ２ NR ｃ１２ R ｄ１２ S(O)R ｂ１２ S(O)NR ｃ１２ R ｄ１２ , S(O) ２ R ｂ１２ , S(O) ２ NR ｃ１２ R ｄ１２ , OS(O)(=NR ｅ１２ ) R ｂ１２ OS(O) ２ R ｂ１２ , S(O)(=NR ｅ１２ ) R ｂ１２ SF ５ P(O)R ｆ１２ R ｇ１２ , OP(O)(OR ｈ１２ ) ( OR ｉ１２ ), P(O)(OR ｈ１２ ) ( OR ｉ１２ ), and BR ｊ１２ R ｋ１２ Selected from, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. Ｇ Substituting with substituents, Each R ａ１２ , R ｃ１２ , and R ｄ１２ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. Ｇ Substituting with substituents, Alternatively, any R bonded to the same N atom ｃ１２ and R ｄ１２ However, together with the N atom to which they are bonded, they form a 4-7 member heterocycloalkyl group, and the 4-7 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. Ｇ Substituting with substituents, Each R ｂ１２ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. Ｇ Substituting with substituents, Each R ｅ１２ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ１２ and R ｇ１２ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ１２ and R ｉ１２ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｊ１２ and R ｋ１２ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ１２ and R ｋ１２ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A five-membered or six-membered heterocycloalkyl group is formed, which is optionally substituted with one, two, three, or four substituents independently selected from the haloalkyl group. R ２ These are independent: H, D, Halo, CN, OH, NO ２ , C １－４ Alkyl, C １－４ Haloalkyl, C ２－４ Alkenil, C ２－４ Alkinyl, C １－４ Alkoxy, C １－４ Haloalkoxy, amino, C １－４ Alkylamino, di(C) １－４ Alkyl)amino, cyano-C １－４ Alkyl, HO-C １－４ Alkyl, C １－４ Alkoxy-C １－４ Alkyl, C ３－４ Cycloalkyl, thio, C １－４ Alkylthio, C １－４ Alkyl sulfinyl, C １－４ Alkyl sulfonyl, carbamyl, C １－４ Alkylcarbamyl, di(C) １－４ Alkyl)carbamyl, carboxy, C １－４ Alkylcarbonyl, C １－４ Alkoxycarbonyl, C １－４ Alkylcarbonyloxy, C １－４ Alkylcarbonylamino, C １－４ Alkoxycarbonylamino, C １－４ Alkylaminocarbonyloxy, C １－４ Alkylsulfonylamino, aminosulfonyl, C １－４ Alkylaminosulfonyl, di(C) １－４ Alkyl)aminosulfonyl, aminosulfonylamino, C １－４ Alkylaminosulfonylamino, di(C) １－４ Alkyl)aminosulfonylamino, aminocarbonylamino, C １－４ Alkylaminocarbonylamino, and di(C １－４ Selected from alkyl)aminocarbonylamino, Each R ３ These became independent: H, D, Halo, CN, C １－４ Alkyl, C １－４ Haloalkyl, C ２－４ Alkenil, C ２－４ Alkinyl, OH, C １－３ Alkoxy, C １－３ Haloalkoxy, amino, C １－３ Alkylamino, di(C) １－３ Alkyl)amino, cyano-C １－４ Alkyl, HO-C １－４ Alkyl, C １－３ Alkoxy-C １－４ Alkyl and C ３－４ Selected from cycloalkyl groups, R ４ However, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ４Ａ Substituted by substituents, Each R ４Ａ These are independent: H, D, Halo, CN, NO ２ , C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl, 5-10 member heteroaryl-C １－４ Alkyl, OR ａ４１ , SR ａ４１ , NHOR ａ４１ , C(O)R ｂ４１ C(O)NR ｃ４１ R ｄ４１ C(O)NR ｃ４１ (OR ａ４１ ), C(O)OR ａ４１ OC(O)R ｂ４１ , OC(O)NR ｃ４１ R ｄ４１ , NR ｃ４１ R ｄ４１ , NR ｃ４１ NR ｃ４１ R ｄ４１ , NR ｃ４１ C(O)R ｂ４１ , NR ｃ４１ C(O)OR ａ４１ , NR ｃ４１ C(O)NR ｃ４１ R ｄ４１ , C(=NR ｅ４１ ) R ｂ４１ , C(=NR ｅ４１ ) NR ｃ４１ R ｄ４１ , NR ｃ４１ C (=NR ｅ４１ ) NR ｃ４１ R ｄ４１ , NR ｃ４１ C (=NR ｅ４１ ) R ｂ４１ , NR ｃ４１ S(O)NR ｃ４１ R ｄ４１ , NR ｃ４１ S(O)R ｂ４１ , NR ｃ４１ S(O) ２ R ｂ４１ , NR ｃ４１ S(O)(=NR ｅ４１ ) R ｂ４１ , NR ｃ４１ S(O) ２ NR ｃ４１ R ｄ４１ S(O)R ｂ４１ S(O)NR ｃ４１ R ｄ４１ , S(O) ２ R ｂ４１ , S(O) ２ NR ｃ４１ R ｄ４１ , OS(O)(=NR ｅ４１ ) R ｂ４１ OS(O) ２ R ｂ４１ , S(O)(=NR ｅ４１ ) R ｂ４１ SF ５ P(O)R ｆ４１ R ｇ４１ , OP(O)(OR ｈ４１ ) ( OR ｉ４１ ), P(O)(OR ｈ４１ ) ( OR ｉ４１ ), and BR ｊ４１ R ｋ４１ Selected from, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ４Ｂ Substituting with substituents, Each R ａ４１ , R ｃ４１ , and R ｄ４１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ４Ｂ Substituting with substituents, Alternatively, any R bonded to the same N atom ｃ４１ and R ｄ４１ However, together with the N atom to which they are bonded, they form a 4- to 10-membered heterocycloalkyl group, and the 4- to 10-membered heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. ４Ｂ Substituting with substituents, Each R ｂ４１ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. ４Ｂ Substituting with substituents, Each R ｅ４１ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ４１ and R ｇ４１ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ４１ and R ｉ４１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｊ４１ and R ｋ４１ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ４１ and R ｋ４１ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A 5-membered or 10-membered heterocycloalkyl group is formed, which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from the haloalkyl group. Each R ４Ｂ These are independent: H, D, Halo, CN, NO ２ , C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl, 5-6 member heteroaryl-C １－４ Alkyl, OR ａ４２ , SR ａ４２ , NHOR ａ４２ , C(O)R ｂ４２ C(O)NR ｃ４２ R ｄ４２ C(O)NR ｃ４２ (OR ａ４２ ), C(O)OR ａ４２ OC(O)R ｂ４２ , OC(O)NR ｃ４２ R ｄ４２ , NR ｃ４２ R ｄ４２ , NR ｃ４２ NR ｃ４２ R ｄ４２ , NR ｃ４２ C(O)R ｂ４２ , NR ｃ４２ C(O)OR ａ４２ , NR ｃ４２ C(O)NR ｃ４２ R ｄ４２ , C(=NR ｅ４２ ) R ｂ４２ , C(=NR ｅ４２ ) NR ｃ４２ R ｄ４２ , NR ｃ４２ C (=NR ｅ４２ ) NR ｃ４２ R ｄ４２ , NR ｃ４２ C (=NR ｅ４２ ) R ｂ４２ , NR ｃ４２ S(O)NR ｃ４２ R ｄ４２ , NR ｃ４２ S(O)R ｂ４２ , NR ｃ４２ S(O) ２ R ｂ４２ , NR ｃ４２ S(O)(=NR ｅ４２ )R ｂ４２ , NR ｃ４２ S(O) ２ NR ｃ４２ R ｄ４２ , S(O)R ｂ４２ , S(O)NR ｃ４２ R ｄ４２ , S(O) ２ R ｂ４２ , S(O) ２ NR ｃ４２ R ｄ４２ , OS(O)(=NR ｅ４２ )R ｂ４２ , OS(O) ２ R ｂ４２ , S(O)(=NR ｅ４２ )R ｂ４２ , SF ５ , P(O)R ｆ４２ R ｇ４２ , OP(O)(OR ｈ４２ )(OR ｉ４２ ), P(O)(OR ｈ４２ )(OR ｉ４２ , and BR ｊ４２ R ｋ４２ selected from, wherein the C １－６ alkyl, C ２－６ alkenyl, C ２－６ alkynyl, C １－６ haloalkyl, C ３－７ cycloalkyl, phenyl, 4- to 7-member heterocycloalkyl, 5- to 6-member heteroaryl, C ３－７ cycloalkyl-C １－４ alkyl, phenyl-C １－４ alkyl, 4- to 7-member heterocycloalkyl-C １－４ alkyl, and 5- to 6-member heteroaryl-C １－４ alkyl is each optionally, independently selected from 1, 2, 3, or 4 R ４Ｃ substituents Each R ａ４２ , R ｃ４２ , and R ｄ４２ is independently H, C １－６ alkyl, C １－６ haloalkyl, C ２－６ alkenyl, C ２－６ alkynyl, C ３－７ cycloalkyl, phenyl, 4- to 7-membered heterocycloalkyl, 5- to 6-membered heteroaryl, C ３－７ cycloalkyl-C １－４ alkyl, phenyl-C １－４ alkyl, 4- to 7-membered heterocycloalkyl-C １－４ alkyl, and 5- to 6-membered heteroaryl-C １－４ alkyl, selected from, said C １－６ alkyl, C ２－６ alkenyl, C ２－６ alkynyl, C １－６ haloalkyl, C ３－７ cycloalkyl, phenyl, 4- to 7-membered heterocycloalkyl, 5- to 6-membered heteroaryl, C ３－７ cycloalkyl-C １－４ alkyl, phenyl-C １－４ alkyl, 4- to 7-membered heterocycloalkyl-C １－４ alkyl, and 5- to 6-membered heteroaryl-C １－４ alkyl is each optionally, 1, 2, 3, or 4 independently selected R ４Ｃ substituted with substituents, or Alternatively, any R bonded to the same N atom ｃ４２ and R ｄ４２ However, together with the N atom to which they are bonded, they form a 4-7 member heterocycloalkyl group, and the 4-7 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. ４Ｃ Substituting with substituents, Each R ｂ４２ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. ４Ｃ Substituting with substituents, Each R ｅ４２ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ４２ and R ｇ４２ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ４２ and R ｉ４２ are independently selected from H, C １－６ alkyl, C １－６ haloalkyl, C ２－６ alkenyl, C ２－６ alkynyl, C ３－７ cycloalkyl, phenyl, 4- to 7-membered heterocycloalkyl, 5- to 6-membered heteroaryl, C ３－７ cycloalkyl-C １－４ alkyl, phenyl-C １－４ alkyl, 4- to 7-membered heterocycloalkyl-C １－４ alkyl, and 5- to 6-membered heteroaryl-C １－４ alkyl, Each R ｊ４２ and R ｋ４２ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ４２ and R ｋ４２ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A five-membered or six-membered heterocycloalkyl group is formed, which is optionally substituted with one, two, three, or four substituents independently selected from the haloalkyl group. Each R ４Ｃ These are independent: H, D, Halo, CN, NO ２ , C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl, 5-6 member heteroaryl-C １－４ Alkyl, OR ａ４３ , SR ａ４３ , NHOR ａ４３ , C(O)R ｂ４３ C(O)NR ｃ４３ R ｄ４３ C(O)NR ｃ４３ (OR ａ４３ ), C(O)OR ａ４３ OC(O)R ｂ４３ , OC(O)NR ｃ４３ R ｄ４３ , NR ｃ４３ R ｄ４３ , NR ｃ４３ NR ｃ４３ R ｄ４３ , NR ｃ４３ C(O)R ｂ４３ , NR ｃ４３ C(O)OR ａ４３ , NR ｃ４３ C(O)NR ｃ４３ R ｄ４３ , C(=NR ｅ４３ ) R ｂ４３ , C(=NR ｅ４３ ) NR ｃ４３ R ｄ４３ , NR ｃ４３ C (=NR ｅ４３ ) NR ｃ４３ R ｄ４３ , NR ｃ４３ C (=NR ｅ４３ ) R ｂ４３ , NR ｃ４３ S(O)NR ｃ４３ R ｄ４３ , NR ｃ４３ S(O)R ｂ４３ , NR ｃ４３ S(O) ２ R ｂ４３ , NR ｃ４３ S(O)(=NR ｅ４３ ) R ｂ４３ , NR ｃ４３ S(O) ２ NR ｃ４３ R ｄ４３ S(O)R ｂ４３ S(O)NR ｃ４３ R ｄ４３ , S(O) ２ R ｂ４３ , S(O) ２ NR ｃ４３ R ｄ４３ , OS(O)(=NR ｅ４３ ) R ｂ４３ OS(O) ２ R ｂ４３ , S(O)(=NR ｅ４３ ) R ｂ４３ SF ５ P(O)R ｆ４３ R ｇ４３ , OP(O)(OR ｈ４３ ) ( OR ｉ４３ ), P(O)(OR ｈ４３ ) ( OR ｉ４３ ), and BR ｊ４３ R ｋ４３ Selected from, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. Ｇ Substituting with substituents, Each R ａ４３ , R ｃ４３ , and R ｄ４３ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. Ｇ Substituting with substituents, Alternatively, any R bonded to the same N atom ｃ４３ and R ｄ４３ However, together with the N atom to which they are bonded, they form a 4-7 member heterocycloalkyl group, and the 4-7 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. Ｇ Substituting with substituents, Each R ｂ４３ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. Ｇ Substituting with substituents, Each R ｅ４３ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ４３ and R ｇ４３ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ４３ and R ｉ４３ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｊ４３ and R ｋ４３ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ４３ and R ｋ４３ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A five-membered or six-membered heterocycloalkyl group is formed, which is optionally substituted with one, two, three, or four substituents independently selected from the haloalkyl group. Each R ５ They became independent, H, D, Halo, NO ２ , CN, C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl, 5-10 member heteroaryl-C １－４ Alkyl, OR ａ５ , SR ａ５ , NHOR ａ５ , C(O)R ｂ５ C(O)NR ｃ５ R ｄ５ C(O)NR ｃ５ (OR ａ５ ), C(O)OR ａ５ OC(O)R ｂ５ , OC(O)NR ｃ５ R ｄ５ , NR ｃ５ R ｄ５ , NR ｃ５ NR ｃ５ R ｄ５ , NR ｃ５ C(O)R ｂ５ , NR ｃ５ C(O)OR ａ５ , NR ｃ５ C(O)NR ｃ５ R ｄ５ , C(=NR ｅ５ ) R ｂ５ , C(=NR ｅ５ ) NR ｃ５ R ｄ５ , NR ｃ５ C (=NR ｅ５ ) NR ｃ５ R ｄ５ , NR ｃ５ C (=NR ｅ５ ) R ｂ５ , NR ｃ５ S(O)NR ｃ５ R ｄ５ , NR ｃ５ S(O)R ｂ５ , NR ｃ５ S(O) ２ R ｂ５ , NR ｃ５ S(O)(=NR ｅ５ ) R ｂ５ , NR ｃ５ S(O) ２ NR ｃ５ R ｄ５ S(O)R ｂ５ S(O)NR ｃ５ R ｄ５ , S(O) ２ R ｂ５ , S(O) ２ NR ｃ５ R ｄ５ , OS(O)(=NR ｅ５ ) R ｂ５ OS(O) ２ R ｂ５ , S(O)(=NR ｅ５ ) R ｂ５ SF ５ P(O)R ｆ５ R ｇ５ , OP(O)(OR ｈ５ ) ( OR ｉ５ ), P(O)(OR ｈ５ ) ( OR ｉ５ ), and BR ｊ５ R ｋ５ Selected from, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ５Ａ Substituted by substituents, Each R ａ５ , R ｃ５ , and R ｄ５ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ５Ａ Substituting with substituents, Alternatively, any R bonded to the same N atom ｃ５ and R ｄ５ However, together with the N atom to which they are bonded, they form a 4- to 10-membered heterocycloalkyl group, which can optionally consist of 1, 2, 3, or 4 independently selected R atoms. ５Ａ Substituting with substituents, Each R ｂ５ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. ５Ａ Substituting with substituents, Each R ｅ５ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ５ and R ｇ５ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ５ and R ｉ５ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｊ５ and R ｋ５ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ５ and R ｋ５ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A five-membered or six-membered heterocycloalkyl group is formed, which is optionally substituted with one, two, three, or four substituents independently selected from the haloalkyl group. Each R ５Ａ These are independent: H, D, Halo, CN, NO ２ , C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl, 5-10 member heteroaryl-C １－４ Alkyl, OR ａ５１ , SR ａ５１ , NHOR ａ５１ , C(O)R ｂ５１ C(O)NR ｃ５１ R ｄ５１ C(O)NR ｃ５１ (OR ａ５１ ), C(O)OR ａ５１ OC(O)R ｂ５１ , OC(O)NR ｃ５１ R ｄ５１ , NR ｃ５１ R ｄ５１ , NR ｃ５１ NR ｃ５１ R ｄ５１ , NR ｃ５１ C(O)R ｂ５１ , NR ｃ５１ C(O)OR ａ５１ , NR ｃ５１ C(O)NR ｃ５１ R ｄ５１ , C(=NR ｅ５１ ) R ｂ５１ , C(=NR ｅ５１ ) NR ｃ５１ R ｄ５１ , NR ｃ５１ C (=NR ｅ５１ ) NR ｃ５１ R ｄ５１ , NR ｃ５１ C (=NR ｅ５１ ) R ｂ５１ , NR ｃ５１ S(O)NR ｃ５１ R ｄ５１ , NR ｃ５１ S(O)R ｂ５１ , NR ｃ５１ S(O) ２ R ｂ５１ , NR ｃ５１ S(O)(=NR ｅ５１ ) R ｂ５１ , NR ｃ５１ S(O) ２ NR ｃ５１ R ｄ５１ S(O)R ｂ５１ S(O)NR ｃ５１ R ｄ５１ , S(O) ２ R ｂ５１ , S(O) ２ NR ｃ５１ R ｄ５１ , OS(O)(=NR ｅ５１ ) R ｂ５１ OS(O) ２ R ｂ５１ , S(O)(=NR ｅ５１ ) R ｂ５１ SF ５ P(O)R ｆ５１ R ｇ５１ , OP(O)(OR ｈ５１ ) ( OR ｉ５１ ), P(O)(OR ｈ５１ ) ( OR ｉ５１ ), and BR ｊ５１ R ｋ５１ Selected from, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ５Ｂ Substituting with substituents, Each R ａ５１ , R ｃ５１ , and R ｄ５１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ５Ｂ Substituting with substituents, Alternatively, any R bonded to the same N atom ｃ５１ and R ｄ５１ However, together with the N atom to which they are bonded, they form a 4- to 7-membered heterocycloalkyl group, which can optionally consist of 1, 2, 3, or 4 independently selected R atoms. ５Ｂ Substituting with substituents, Each R ｂ５１ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. ５Ｂ Substituting with substituents, Each R ｅ５１ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ５１ and R ｇ５１ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ５１ and R ｉ５１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C ３－１０ Cycloalkyl-C １－４ Alkyl, 6-10 membered aryl-C １－４ Alkyl, 4-10 member heterocycloalkyl-C １－４ Alkyl and 5-10 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｊ５１ and R ｋ５１ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ５１ and R ｋ５１ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A five-membered or six-membered heterocycloalkyl group is formed, which is optionally substituted with one, two, three, or four substituents independently selected from the haloalkyl group. Each R ５Ｂ These are independent: H, D, Halo, CN, NO ２ , C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl, 5-6 member heteroaryl-C １－４ Alkyl, OR ａ５２ , SR ａ５２ , NHOR ａ５２ , C(O)R ｂ５２ C(O)NR ｃ５２ R ｄ５２ C(O)NR ｃ５２ (OR ａ５２ ), C(O)OR ａ５２ OC(O)R ｂ５２ , OC(O)NR ｃ５２ R ｄ５２ , NR ｃ５２ R ｄ５２ , NR ｃ５２ NR ｃ５２ R ｄ５２ , NR ｃ５２ C(O)R ｂ５２ , NR ｃ５２ C(O)OR ａ５２ , NR ｃ５２ C(O)NR ｃ５２ R ｄ５２ , C(=NR ｅ５２ ) R ｂ５２ , C(=NR ｅ５２ ) NR ｃ５２ R ｄ５２ , NR ｃ５２ C (=NR ｅ５２ ) NR ｃ５２ R ｄ５２ , NR ｃ５２ C (=NR ｅ５２ ) R ｂ５２ , NR ｃ５２ S(O)NR ｃ５２ R ｄ５２ , NR ｃ５２ S(O)R ｂ５２ , NR ｃ５２ S(O) ２ R ｂ５２ , NR ｃ５２ S(O)(=NR ｅ５２ ) R ｂ５２ , NR ｃ５２ S(O) ２ NR ｃ５２ R ｄ５２ S(O)R ｂ５２ S(O)NR ｃ５２ R ｄ５２ , S(O) ２ R ｂ５２ , S(O) ２ NR ｃ５２ R ｄ５２ , OS(O)(=NR ｅ５２ ) R ｂ５２ OS(O) ２ R ｂ５２ , S(O)(=NR ｅ５２ ) R ｂ５２ SF ５ P(O)R ｆ５２ R ｇ５２ , OP(O)(OR ｈ５２ ) ( OR ｉ５２ ), P(O)(OR ｈ５２ ) ( OR ｉ５２ ), and BR ｊ５２ R ｋ５２ Selected from, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ５Ｃ Substituting with substituents, Each R ａ５２ , R ｃ５２ , and R ｄ５２ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ５Ｃ Substituting with substituents, Alternatively, any R bonded to the same N atom ｃ５２ and R ｄ５２ However, together with the N atom to which they are bonded, they form a 4- to 7-membered heterocycloalkyl group, which can optionally consist of 1, 2, 3, or 4 independently selected R atoms. ５Ｃ Substituting with substituents, Each R ｂ５２ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. ５Ｃ Substituting with substituents, Each R ｅ５２ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ５２ and R ｇ５２ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ５２ and R ｉ５２ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｊ５２ and R ｋ５２ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ５２ and R ｋ５２ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A five-membered or six-membered heterocycloalkyl group is formed, which is optionally substituted with one, two, three, or four substituents independently selected from the haloalkyl group. Each R ５Ｃ These are independent: H, D, Halo, CN, NO ２ , C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl, 5-6 member heteroaryl-C １－４ Alkyl, OR ａ５３ , SR ａ５３ , NHOR ａ５３ , C(O)R ｂ５３ C(O)NR ｃ５３ R ｄ５３ C(O)NR ｃ５３ (OR ａ５３ ), C(O)OR ａ５３ OC(O)R ｂ５３ , OC(O)NR ｃ５３ R ｄ５３ , NR ｃ５３ R ｄ５３ , NR ｃ５３ NR ｃ５３ R ｄ５３ , NR ｃ５３ C(O)R ｂ５３ , NR ｃ５３ C(O)OR ａ５３ , NR ｃ５３ C(O)NR ｃ５３ R ｄ５３ , C(=NR ｅ５３ ) R ｂ５３ , C(=NR ｅ５３ ) NR ｃ５３ R ｄ５３ , NR ｃ５３ C (=NR ｅ５３ ) NR ｃ５３ R ｄ５３ , NR ｃ５３ C (=NR ｅ５３ ) R ｂ５３ , NR ｃ５３ S(O)NR ｃ５３ R ｄ５３ , NR ｃ５３ S(O)R ｂ５３ , NR ｃ５３ S(O) ２ R ｂ５３ , NR ｃ５３ S(O)(=NR ｅ５３ ) R ｂ５３ , NR ｃ５３ S(O) ２ NR ｃ５３ R ｄ５３ S(O)R ｂ５３ S(O)NR ｃ５３ R ｄ５３ , S(O) ２ R ｂ５３ , S(O) ２ NR ｃ５３ R ｄ５３ , OS(O)(=NR ｅ５３ ) R ｂ５３ OS(O) ２ R ｂ５３ , S(O)(=NR ｅ５３ ) R ｂ５３ SF ５ P(O)R ｆ５３ R ｇ５３ , OP(O)(OR ｈ５３ ) ( OR ｉ５３ ), P(O)(OR ｈ５３ ) ( OR ｉ５３ ), and BR ｊ５３ R ｋ５３ Selected from, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. Ｇ Substituting with substituents, Each R ａ５３ , R ｃ５３ , and R ｄ５３ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. Ｇ Substituting with substituents, Alternatively, any R bonded to the same N atom ｃ５３ and R ｄ５３ However, together with the N atom to which they are bonded, they form a 4- to 7-membered heterocycloalkyl group, which can optionally consist of 1, 2, 3, or 4 independently selected R atoms. Ｇ Substituting with substituents, Each R ｂ５３ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. Ｇ Substituting with substituents, Each R ｅ５３ These are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｆ５３ and R ｇ５３ H and C became independent. １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｈ５３ and R ｉ５３ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, Each R ｊ５３ and R ｋ５３ OH and C are independent of each other. １－６ Alkoxy and C １－６ Selected from haloalkoxys, Alternatively, any R bonded to the same B atom ｊ５３ and R ｋ５３ However, together with the aforementioned B atoms to which they are bonded, C １－６ Alkyl and C １－６ A five-membered or six-membered heterocycloalkyl group is formed, which is optionally substituted with one, two, three, or four substituents independently selected from the haloalkyl group. Each R Ｇ They become independent, OH, NO ２ , CN, Halo, C １－３ Alkyl, C ２－３ Alkenil, C ２－３ Alkinyl, C １－３ Haloalkyl, cyano-C １－３ Alkyl, HO-C １－３ Alkyl, C １－３ Alkoxy-C １－３ Alkyl, C ３－７ Cycloalkyl, C １－３ Alkoxy, C １－３ Haloalkoxy, amino, C １－３ Alkylamino, di(C) １－３ Alkyl)amino, thio, C １－３ Alkylthio, C １－３ Alkyl sulfinyl, C １－３ Alkyl sulfonyl, carbamyl, C １－３ Alkylcarbamyl, di(C) １－３ Alkyl)carbamyl, carboxy, C １－３ Alkylcarbonyl, C １－３ Alkoxycarbonyl, C １－３ Alkylcarbonyloxy, C １－３ Alkylcarbonylamino, C １－３ Alkoxycarbonylamino, C １－３ Alkylaminocarbonyloxy, C １－３ Alkylsulfonylamino, aminosulfonyl, C １－３ Alkylaminosulfonyl, di(C) １－３ Alkyl)aminosulfonyl, aminosulfonylamino, C １－３ Alkylaminosulfonylamino, di(C) １－３ Alkyl)aminosulfonylamino, aminocarbonylamino, C １－３ Alkylaminocarbonylamino, and di(C １－３ Selected from alkyl)aminocarbonylamino, The aforementioned compound, or a pharmaceutically acceptable salt thereof.

2. R １ They became independent: H, Halo, CN, NO ２ , C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl, 5-6 member heteroaryl-C １－４ Alkyl, OR ａ１ , SR ａ１ , C(O)R ｂ１ C(O)NR ｃ１ R ｄ１ , C(O)OR ａ１ OC(O)R ｂ１ , OC(O)NR ｃ１ R ｄ１ , NR ｃ１ R ｄ１ , NR ｃ１ C(O)R ｂ１ , NR ｃ１ C(O)OR ａ１ , NR ｃ１ C(O)NR ｃ１ R ｄ１ , NR ｃ１ S(O) ２ R ｂ１ , NR ｃ１ S(O) ２ NR ｃ１ R ｄ１ , S(O) ２ R ｂ１ , and S(O) ２ NR ｃ１ R ｄ１ Selected from, the C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. １Ａ A compound according to claim 1, or a pharmaceutically acceptable salt thereof, substituted with a substituent.

3. R １ They became independent: H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－３ Alkyl, phenyl-C １－３ Alkyl, 4-7 member heterocycloalkyl-C １－３ Alkyl, 5-6 member heteroaryl-C １－３ Alkyl, OR ａ１ , SR ａ１ , and NR ｃ１ R ｄ１ Selected from, the C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－３ Alkyl, phenyl-C １－３ Alkyl, 4-7 member heterocycloalkyl-C １－３ Alkyl and 5-6 member heteroaryl-C １－３ The alkyl group consists of one or two independently selected R groups, each of which can be arbitrarily chosen. １Ａ A compound according to claim 1, or a pharmaceutically acceptable salt thereof, substituted with a substituent.

4. R １ H and C became independent. １－６ Alkyl, phenyl, 5-7 member heterocycloalkyl, OR ａ１ , SR ａ１ , and NR ｃ１ R ｄ１ Selected from, the C １－６ Alkyl, phenyl, and 5- to 7-membered heterocycloalkyl groups are each optionally selected as one or two independently selected R groups. １Ａ A compound according to claim 1, or a pharmaceutically acceptable salt thereof, substituted with a substituent.

5. R １ H and OR are independent of each other. ａ１ A compound according to claim 1, or a pharmaceutically acceptable salt thereof, selected from the above.

6. Each R ａ１ , R ｃ１ , and R ｄ１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. １Ａ Substituting with substituents, Each R ｂ１ C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. １Ａ Substituting with substituents, Each R １Ａ These are independent: H, D, Halo, CN, NO ２ , C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl, 5-6 member heteroaryl-C １－４ Alkyl, OR ａ１１ , C(O)R ｂ１１ C(O)NR ｃ１１ R ｄ１１ , C(O)OR ａ１１ OC(O)R ｂ１１ , OC(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ R ｄ１１ , NR ｃ１１ C(O)R ｂ１１ , NR ｃ１１ C(O)OR ａ１１ , NR ｃ１１ C(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ S(O) ２ R ｂ１１ , NR ｃ１１ S(O) ２ NR ｃ１１ R ｄ１１ , S(O) ２ R ｂ１１ , and S(O) ２ NR ｃ１１ R ｄ１１ Selected from, the C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. １Ｂ Substituting with substituents, Each R ａ１１ , R ｃ１１ , and R ｄ１１ H and C became independent. １－６ Alkyl and C １－６ Selected from haloalkyls, Each R ｂ１１ C １－６ Alkyl and C １－６ Selected from haloalkyls, Each R １Ｂ H, D, and OR are independent. ａ１２ Selected from, Each R ａ１２ H and C are independent of each other. １－６ Selected from alkyl groups, A compound according to any one of claims 1 to 5, or a pharmaceutically acceptable salt thereof.

7. Each R ａ１ , R ｃ１ , and R ｄ１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ３－６ Cycloalkyl, phenyl, 4-6 member heterocycloalkyl, C ３－６ Cycloalkyl-C １－３ Alkyl and 4-6 member heterocycloalkyl-C １－３ Selected from alkyl, the C １－６ Alkyl, C １－６ Haloalkyl, C ３－６ Cycloalkyl, phenyl, 4-6 member heterocycloalkyl, C ３－６ Cycloalkyl-C １－３ Alkyl and 4-6 member heterocycloalkyl-C １－３ Alkyl groups are selected from 1, 2, or 3 independently chosen groups. １Ａ Substituting with substituents, Each R ｂ１ C １－６ Alkyl, C １－６ Haloalkyl, C ３－６ Cycloalkyl, 4-6 member heterocycloalkyl, C ３－６ Cycloalkyl-C １－２ Alkyl and 4-6 member heterocycloalkyl-C １－２ Selected from alkyl groups, each of which can be optionally selected as one or two independently R groups. １Ａ Substituting with substituents, Each R １Ａ These became independent: H, D, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, OR ａ１１ , and C(O)OR ａ１１ Selected from, the C １－６ Alkyl and C １－６ The haloalkyl group consists of one, two, or three independently selected R groups, each of which can be arbitrarily chosen. １Ｂ Substituting with substituents, Each R ａ１１ H and C are independent of each other. １－４ Selected from alkyl, the C １－４ The alkyl group is optionally selected from 1, 2, or 3 independently selected R groups. １Ｂ Substituted by substituents, Each R １Ｂ These are independently H, D, and O-C １－４ Selected from alkyl groups, A compound according to any one of claims 1 to 5, or a pharmaceutically acceptable salt thereof.

8. R １ However, OR ａ１ And R ａ１ However, C １－３ The compound according to claim 1, or a pharmaceutically acceptable salt thereof, which is alkyl.

9. R ２ However, H, Halo, CN, C １－４ Alkyl, C １－４ Haloalkyl, C ２－４ Alkenil, C ２－４ Alkinyl, OH, C １－３ Alkoxy, C １－３ Haloalkoxy, amino, C １－３ Alkylamino, di(C) １－３ Alkyl)amino, cyano-C １－４ Alkyl, HO-C １－４ Alkyl, C １－３ Alkoxy-C １－４ Alkyl and C ３－４ A compound according to any one of claims 1 to 8, selected from cycloalkyls, or a pharmaceutically acceptable salt thereof.

10. R ２ The compound according to any one of claims 1 to 8, or a pharmaceutically acceptable salt thereof, wherein the compound is H or a halo.

11. R ２ A compound according to any one of claims 1 to 8, wherein the compound is H or F, or a pharmaceutically acceptable salt thereof.

12. The compound according to any one of claims 1 to 11, wherein the ring portion B is a monocyclic 4- to 7-membered heterocycloalkyl, or a pharmaceutically acceptable salt thereof.

13. The compound according to any one of claims 1 to 11, wherein ring portion B is piperidinyl, or a pharmaceutically acceptable salt thereof.

14. A compound according to any one of claims 1 to 13, or a pharmaceutically acceptable salt thereof, wherein n is 0 or 1.

15. Each R ３ A compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof, wherein the compound is independently selected from H, F, and methyl.

16. Each R ３ A compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof, wherein the compound is independently selected from H and methyl.

17. R ４ However, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ４Ａ A compound according to any one of claims 1 to 16, substituted with a substituent, or a pharmaceutically acceptable salt thereof.

18. R ４ However, C １－６ Alkyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, and 4-7 member heterocycloalkyl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, and 4-7 member heterocycloalkyl-C １－４ The alkyl group consists of one or two independently selected R groups, each of which can be arbitrarily chosen. ４Ａ A compound according to any one of claims 1 to 16, substituted with a substituent, or a pharmaceutically acceptable salt thereof.

19. R ４ However, C １－６ Alkyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, and 4-7 member heterocycloalkyl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ３－６ Cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally selected as one or two independently of each other. ４Ａ A compound according to any one of claims 1 to 16, substituted with a substituent, or a pharmaceutically acceptable salt thereof.

20. R ４ However, C １－６ Alkyl and C ３－６ A compound according to any one of claims 1 to 16, which is a cycloalkyl compound, or a pharmaceutically acceptable salt thereof.

21. Each R ４Ａ They became independent: H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－４ Cycloalkyl, OR ａ４１ , C(O)R ｂ４１ C(O)NR ｃ４１ R ｄ４１ , C(O)OR ａ４１ OC(O)R ｂ４１ , OC(O)NR ｃ４１ R ｄ４１ , NR ｃ４１ R ｄ４１ , NR ｃ４１ C(O)R ｂ４１ , NR ｃ４１ C(O)OR ａ４１ , NR ｃ４１ C(O)NR ｃ４１ R ｄ４１ , NR ｃ４１ S(O) ２ R ｂ４１ , NR ｃ４１ S(O) ２ NR ｃ４１ R ｄ４１ , S(O) ２ R ｂ４１ , and S(O) ２ NR ｃ４１ R ｄ４１ Selected from, the C １－６ Alkyl, C １－６ Haloalkyl and C ３－４ The cycloalkyl group consists of one, two, or three independently selected R groups, each of which can be arbitrarily chosen. ４Ｂ Substituting with substituents, Each R ａ４１ , R ｃ４１ , and R ｄ４１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl and C ３－４ Selected from cycloalkyl, the C １－６ Alkyl, C １－６ Haloalkyl and C ３－４ Each cycloalkyl group is optionally selected from one or two independently selected R groups. ４Ｂ Substituting with substituents, Each R ｂ４１ C １－６ Alkyl, C １－６ Haloalkyl and C ３－４ R is selected from cycloalkyl groups, each of which is optionally selected as one or two independently. ４Ｂ Substituting with substituents, Each R ４Ｂ They became independent: H, Halo, CN, C １－３ Alkyl, C １－３ Haloalkyl, OR ａ４２ , and NR ｃ４２ R ｄ４２ Selected from, Each R ａ４２ , R ｃ４２ , and R ｄ４２ H and C became independent. １－３ Alkyl and C １－３ Selected from haloalkyls, Each R ｂ４２ C １－３ Alkyl and C １－３ Selected from haloalkyl groups, A compound according to any one of claims 1 to 20, or a pharmaceutically acceptable salt thereof.

22. Each R ４Ａ They became independent: H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－４ Cycloalkyl, OR ａ４１ , C(O)R ｂ４１ C(O)NR ｃ４１ R ｄ４１ , C(O)OR ａ４１ OC(O)R ｂ４１ , OC(O)NR ｃ４１ R ｄ４１ , NR ｃ４１ R ｄ４１ , NR ｃ４１ C(O)R ｂ４１ , NR ｃ４１ C(O)OR ａ４１ , NR ｃ４１ C(O)NR ｃ４１ R ｄ４１ , NR ｃ４１ S(O) ２ R ｂ４１ , NR ｃ４１ S(O) ２ NR ｃ４１ R ｄ４１ , S(O) ２ R ｂ４１ , and S(O) ２ NR ｃ４１ R ｄ４１ Selected from, Each R ａ４１ , R ｃ４１ , and R ｄ４１ H and C became independent. １－３ Alkyl and C １－３ Selected from haloalkyls, Each R ｂ４１ C １－３ Alkyl and C １－３ Selected from haloalkyl groups, A compound according to any one of claims 1 to 20, or a pharmaceutically acceptable salt thereof.

23. Each R ４Ａ They became independent: H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, OR ａ４１ , and NR ｃ４１ R ｄ４１ Selected from, Each R ａ４１ , R ｃ４１ , and R ｄ４１ H and C are independent of each other. １－３ Alkyl and C １－３ Selected from haloalkyls, Each R ｂ４１ However, C １－３ It is alkyl. A compound according to any one of claims 1 to 20, or a pharmaceutically acceptable salt thereof.

24. The compound according to any one of claims 1 to 23, wherein ring portion A is a 5- to 10-membered heteroaryl compound, or a pharmaceutically acceptable salt thereof.

25. The compound according to any one of claims 1 to 23, wherein the ring portion A is a 5- to 6-membered heteroaryl compound, or a pharmaceutically acceptable salt thereof.

26. The compound according to any one of claims 1 to 23, or a pharmaceutically acceptable salt thereof, wherein ring portion A is 1H-pyrrolo[2,3-b]pyridinyl, pyridinyl, or pyrazolyl.

27. The compound according to any one of claims 1 to 23, wherein ring portion A is pyrazolyl, or a pharmaceutically acceptable salt thereof.

28. A compound according to any one of claims 1 to 27, or a pharmaceutically acceptable salt thereof, wherein p is 0 or 1.

29. Each R ５ They became independent: H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－４ Cycloalkyl, OR ａ５ , and NR ｃ５ R ｄ５ Selected from, each R ａ５ , R ｃ５ , and R ｄ５ H and C became independent. １－６ Alkyl and C １－６ A compound according to any one of claims 1 to 28, selected from haloalkyls, or a pharmaceutically acceptable salt thereof.

30. Each R ５ CH became independent, ３ or NH ２ A compound according to any one of claims 1 to 28, selected from, or a pharmaceutically acceptable salt thereof.

31. n is 0, 1, or 2, p is 0, 1, or 2, Ring portion A is C ３－１０ Selected from cycloalkyl, 6-10 membered aryl, 4-10 membered heterocycloalkyl, and 5-10 membered heteroaryl, Ring portion B is azetidinil, pyrrolidinil, or piperidinil. R １ However, H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－６ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－６ Cycloalkyl-C １－３ Alkyl, phenyl-C １－３ Alkyl, 4-7 member heterocycloalkyl-C １－３ Alkyl, 5-6 member heteroaryl-C １－３ Alkyl, OR ａ１ , SR ａ１ , and NR ｃ１ R ｄ１ And the above C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C １－６ Haloalkyl, C ３－６ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－６ Cycloalkyl-C １－３ Alkyl, phenyl-C １－３ Alkyl, 4-7 member heterocycloalkyl-C １－３ Alkyl and 5-6 member heteroaryl-C １－３ Alkyl groups are selected from 1, 2, or 3 independently chosen groups. １Ａ Substituting with substituents, Each R ａ１ , R ｃ１ , and R ｄ１ They became independent: H, D, C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, and C ３－７ Cycloalkyl-C １－４ Selected from alkyl, the C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, and C ３－７ Cycloalkyl-C １－４ Alkyl groups are selected from 1, 2, or 3 independently chosen groups. １Ａ Substituting with substituents, Each R １Ａ These became independent: H, D, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－４ Cycloalkyl, OR ａ１１ , C(O)R ｂ１１ C(O)NR ｃ１１ R ｄ１１ , C(O)OR ａ１１ OC(O)R ｂ１１ , OC(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ R ｄ１１ , NR ｃ１１ C(O)R ｂ１１ , NR ｃ１１ C(O)OR ａ１１ , NR ｃ１１ C(O)NR ｃ１１ R ｄ１１ , NR ｃ１１ S(O) ２ R ｂ１１ , NR ｃ１１ S(O) ２ NR ｃ１１ R ｄ１１ , S(O) ２ R ｂ１１ , and S(O) ２ NR ｃ１１ R ｄ１１ Selected from, the C １－６ Alkyl, C １－６ Haloalkyl and C ３－４ The cycloalkyl group consists of one, two, or three independently selected R groups, each of which can be arbitrarily chosen. １Ｂ Substituted by substituents, Each R ａ１１ , R ｃ１１ , and R ｄ１１ H and C became independent. １－６ Alkyl and C １－６ Selected from haloalkyls, Each R ｂ１１ C １－６ Alkyl and C １－６ Selected from haloalkyls, Each R １Ｂ H, D, and OR are independent. ａ１２ Selected from, Each R ａ１２ H and C are independent of each other. １－６ Selected from alkyl groups, R ２ However, H, Halo, CN, C １－３ Alkyl and C １－３ Selected from haloalkyls, Each R ３ They became independent as H, Halo, and C １－３ Selected from alkyl and cyclopropyl, R ４ However, C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, and 4-7 member heterocycloalkyl-C １－４ Selected from alkyl, the C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, and 4-7 member heterocycloalkyl-C １－４ The alkyl group consists of one or two independently selected R groups, each of which can be arbitrarily chosen. ４Ａ Substituted by substituents, Each R ４Ａ They became independent: H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－４ Cycloalkyl, OR ａ４１ , C(O)R ｂ４１ C(O)NR ｃ４１ R ｄ４１ , C(O)OR ａ４１ OC(O)R ｂ４１ , OC(O)NR ｃ４１ R ｄ４１ , NR ｃ４１ R ｄ４１ , NR ｃ４１ C(O)R ｂ４１ , NR ｃ４１ C(O)OR ａ４１ , NR ｃ４１ C(O)NR ｃ４１ R ｄ４１ , NR ｃ４１ S(O) ２ R ｂ４１ , NR ｃ４１ S(O) ２ NR ｃ４１ R ｄ４１ , S(O) ２ R ｂ４１ , and S(O) ２ NR ｃ４１ R ｄ４１ Selected from, the C １－６ Alkyl, C １－６ Haloalkyl and C ３－４ The cycloalkyl group consists of one, two, or three independently selected R groups, each of which can be arbitrarily chosen. ４Ｂ Substituting with substituents, Each R ａ４１ , R ｃ４１ , and R ｄ４１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl and C ３－４ Selected from cycloalkyl, the C １－６ Alkyl, C １－６ Haloalkyl and C ３－４ Each cycloalkyl group is optionally selected from one or two independently selected R groups. ４Ｂ Substituting with substituents, Each R ｂ４１ C １－６ Alkyl, C １－６ Haloalkyl and C ３－４ R is selected from cycloalkyl groups, each of which is optionally selected as one or two independently. ４Ｂ Substituting with substituents, Each R ４Ｂ They became independent: H, Halo, CN, C １－３ Alkyl, C １－３ Haloalkyl, OR ａ４２ , and NR ｃ４２ R ｄ４２ Selected from, Each R ａ４２ , R ｃ４２ , and R ｄ４２ H and C became independent. １－３ Alkyl and C １－３ Selected from haloalkyls, Each R ｂ４２ C １－３ Alkyl and C １－３ Selected from haloalkyls, Each R ５ They became independent, H, Haro, NO ２ , CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl, 5-6 member heteroaryl-C １－４ Alkyl, OR ａ５ , SR ａ５ , NHOR ａ５ , C(O)R ｂ５ C(O)NR ｃ５ R ｄ５ , C(O)OR ａ５ OC(O)R ｂ５ , OC(O)NR ｃ５ R ｄ５ , NR ｃ５ R ｄ５ , NR ｃ５ C(O)R ｂ５ , NR ｃ５ C(O)OR ａ５ , NR ｃ５ C(O)NR ｃ５ R ｄ５ , NR ｃ５ S(O) ２ R ｂ５ , NR ｃ５ S(O) ２ NR ｃ５ R ｄ５ , S(O) ２ R ｂ５ , and S(O) ２ NR ｃ５ R ｄ５ Selected from, the C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ５Ａ Substituted by substituents, Each R ａ５ , R ｃ５ , and R ｄ５ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl, the C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ５Ａ Substituting with substituents, Each R ｂ５ C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, phenyl, 4-7 member heterocycloalkyl, 5-6 member heteroaryl, C ３－７ Cycloalkyl-C １－４ Alkyl, phenyl-C １－４ Alkyl, 4-7 member heterocycloalkyl-C １－４ Alkyl and 5-6 member heteroaryl-C １－４ Selected from alkyl groups, these are each optionally selected as 1, 2, 3, or 4 independently R groups. ５Ａ Substituting with substituents, Each R ５Ａ They became independent: H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－４ Cycloalkyl, OR ａ５１ , SR ａ５１ , NHOR ａ５１ , C(O)R ｂ５１ C(O)NR ｃ５１ R ｄ５１ , C(O)OR ａ５１ OC(O)R ｂ５１ , OC(O)NR ｃ５１ R ｄ５１ , NR ｃ５１ R ｄ５１ , NR ｃ５１ C(O)R ｂ５１ , NR ｃ５１ C(O)OR ａ５１ , NR ｃ５１ C(O)NR ｃ５１ R ｄ５１ , NR ｃ５１ S(O) ２ R ｂ５１ , NR ｃ５１ S(O) ２ NR ｃ５１ R ｄ５１ , S(O) ２ R ｂ５１ , and S(O) ２ NR ｃ５１ R ｄ５１ Selected from, Each R ａ５１ , R ｃ５１ , and R ｄ５１ H and C became independent. １－６ Alkyl and C １－６ Selected from haloalkyls, Each R ｂ５１ C １－６ Alkyl and C １－６ Selected from haloalkyl groups, The compound according to claim 1, or a pharmaceutically acceptable salt thereof.

32. n is 0 or 1, p is 0 or 1, Ring portion A is a 5- to 10-membered heteroaryl having one or two N-ring forming atoms. Ring portion B is piperidinyl, R １ H and C became independent. １－６ Alkyl, phenyl, 5-7 member heterocycloalkyl, OR ａ１ , SR ａ１ , and NR ｃ１ R ｄ１ Selected from, the C １－６ Alkyl, phenyl, and 5- to 7-membered heterocycloalkyl groups are each optionally selected as one or two independently selected R groups. １Ａ Substituting with substituents, Each R ａ１ , R ｃ１ , and R ｄ１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ３－６ Cycloalkyl, phenyl, 4-6 member heterocycloalkyl, C ３－６ Cycloalkyl-C １－３ Alkyl and 4-6 member heterocycloalkyl-C １－３ Selected from alkyl, the C １－６ Alkyl, C １－６ Haloalkyl, C ３－６ Cycloalkyl, phenyl, 4-6 member heterocycloalkyl, C ３－６ Cycloalkyl-C １－３ Alkyl and 4-6 member heterocycloalkyl-C １－３ Alkyl groups are selected from 1, 2, or 3 independently chosen groups. １Ａ Substituting with substituents, Each R １Ａ They became independent as D, Halo, CN, C １－３ Alkyl, C １－３ Haloalkyl, C ３－４ Cycloalkyl, OR ａ１１ , and C(O)OR ａ１１ Selected from, the C １－６ Alkyl and C １－６ The haloalkyl group consists of one, two, or three independently selected R groups, each of which can be arbitrarily chosen. １Ｂ Substituting with substituents, Each R ａ１１ H and C are independent of each other. １－４ Selected from alkyl, the C １－４ The alkyl group is optionally selected from 1, 2, or 3 independently selected R groups. １Ｂ Substituted by substituents, Each R １Ｂ These are independently H, D, and O-C １－４ Selected from alkyl groups, R ２ However, it is H or F, Each R ３ independently selected from H or methyl, R ４ However, C １－６ Alkyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, and 4-7 member heterocycloalkyl-C １－４ Selected from alkyl, the C １－６ Alkyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, and 4-7 member heterocycloalkyl-C １－４ The alkyl group consists of 1, 2, 3, or 4 independently selected R groups, each of which can be arbitrarily chosen. ４Ａ Substituted by substituents, Each R ４Ａ H and C became independent. １－６ Alkyl, OH, and NR ｃ４１ R ｄ４１ Selected from, Each R ｃ４１ and R ｄ４１ H and C became independent. １－６ Alkyl and C １－６ Selected from haloalkyls, Each R ５ They became independent: H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－４ Cycloalkyl, OR ａ５ , and NR ｃ５ R ｄ５ Selected from, Each R ａ５ , R ｃ５ , and R ｄ５ H and C became independent. １－６ Alkyl and C １－６ Selected from haloalkyl groups, The compound according to claim 1, or a pharmaceutically acceptable salt thereof.

33. n is 0 or 1, p is 0 or 1, Ring portion A is a 5- to 10-membered heteroaryl having one or two N-ring forming atoms. Ring portion B is piperidinyl, R １ H and OR are independent of each other. ａ１ Selected from, Each R ａ１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ３－６ Cycloalkyl, 4-6 member heterocycloalkyl, C ３－６ Cycloalkyl-C １－３ Alkyl and 4-6 member heterocycloalkyl-C １－３ Selected from alkyl, the C １－６ Alkyl, C １－６ Haloalkyl C ３－６ Cycloalkyl, 4-6 member heterocycloalkyl, C ３－６ Cycloalkyl-C １－３ Alkyl and 4-6 member heterocycloalkyl-C １－３ The alkyl group consists of one or two independently selected R groups, each of which can be arbitrarily chosen. １Ａ Substituting with substituents, Each R １Ａ C １－３ Alkyl, C １－３ Haloalkyl, C ３－４ Cycloalkyl, OH, C １－３ Alkoxy and C １－３ Selected from haloalkoxys, R ２ However, it is H or F, Each R ３ independently selected from H or methyl, R ４ However, C １－６ Alkyl and C ３－６ Selected from cycloalkyl, the C １－６ Alkyl and C ３－６ Each cycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R groups. ４Ａ Substituted by substituents, Each R ４Ａ H and C are independent of each other. １－６ Selected from alkyl groups, Each R ５ They became independent: H, Halo, CN, C １－６ Alkyl, C １－６ Haloalkyl, C ３－４ Cycloalkyl, OR ａ５ , and NR ｃ５ R ｄ５ Selected from, Each R ａ５ , R ｃ５ , and R ｄ５ H and C became independent. １－６ Alkyl and C １－６ Selected from haloalkyl groups, The compound according to claim 1, or a pharmaceutically acceptable salt thereof.

34. Equation (Va), or (Vb), or (VC), or (Vd), 【Transformation 7】 The compound according to any one of claims 1 to 33, or having any of the above-mentioned pharmaceutically acceptable salts.

35. Equation (VIa), or (VIIa), or (VIIIIa), or (IXa), 【Transformation 8】 The compound according to any one of claims 1 to 33, or having any of the above-mentioned pharmaceutically acceptable salts.

36. Equation (VIb), or (VIIIIb), or (IXb), 【Chemistry 9】 The compound according to any one of claims 1 to 33, or having any of the above-mentioned pharmaceutically acceptable salts.

37. Formula (VIc), or (VIIIIc), or (IXc), 【Chemistry 10】 The compound according to any one of claims 1 to 33, or having any of the above-mentioned pharmaceutically acceptable salts.

38. N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Ethoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Isobutoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-(cyclopropylmethoxy)-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-((tetrahydro-2H-pyran-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-(2-methoxyethoxy)-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 6-Fluoro-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 8-(2,2-difluoroethoxy)-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-(2,2,2-trifluoroethoxy)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-((tetrahydrofuran-3-yl)methoxy)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Ethoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-1-(cyclopropylsulfonyl)-3-methylpiperidine-4-yl)-8-ethoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Isopropoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-Isobutoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrrolo[2,3-b]pyridine-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, and 7-(2-aminopyridine-4-yl)-8-isobutoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, A compound according to claim 1, or a pharmaceutically acceptable salt thereof, selected from the above.

39. 8-Ethoxy-7-(3-methyl-1H-pyrazole-4-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 4-((2-((1-(methylsulfonyl)piperidine-4-yl)amino)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-8-yl)oxy)piperidine-1-carboxylate methyl, (R)-1-(2-(((3R,4S)-4-((8-ethoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-yl)amino)-3-methylpiperidine-1-yl)sulfonyl)ethyl)pyrrolidine-3-ol, 8-Ethoxy-N-((3R,4S)-3-methyl-1-((1-methyl-1H-pyrazole-4-yl)sulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Ethoxy-N-((3R,4S)-3-methyl-1-((2-methyl-2H-1,2,3-triazole-4-yl)sulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-8-phenyl-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-(4-fluoropiperidine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N ２ -(1-(methylsulfonyl)piperidine-4-yl)-N ８ -phenyl-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine, 8-(4-fluorophenyl)-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Ethoxy-N-((3R,4S)-3-methyl-1-((3-(piperidine-1-yl)propyl)sulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-1-((3-(dimethylamino)propyl)sulfonyl)-3-methylpiperidine-4-yl)-8-ethoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Ethoxy-N-((3R,4S)-3-methyl-1-((3-(pyrrolidine-1-yl)propyl)sulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-(4-(trifluoromethyl)piperidine-1-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-(3-fluoropiperidine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Ethoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-Isopropoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-(4-methylpiperidine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 2-Fluoro-4-(2-((1-(methylsulfonyl)piperidine-4-yl)amino)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-yl)benzonitrile, N-(1-(methylsulfonyl)piperidine-4-yl)-8-propyl-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Isopropoxy-N-((3R,4S)-3-methyl-1-((2-(pyrrolidine-1-yl)ethyl)sulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-((4,4-difluorocyclohexyl)oxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-((tetrahydrofuran-3-yl)oxy)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-(ethoxy-d5)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-((tetrahydro-2H-pyran-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Isopropoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 8-Isobutoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-(2,2-difluoroethoxy)-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-(3,3,3-trifluoropropoxy)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-Butoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-8-propoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-8-(piperidine-1-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-(3-methyl-1-(methylsulfonyl)piperidine-4-yl)-8-(piperidine-1-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-(4-(2-methoxyethyl)piperazine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-8-(pyrrolidine-1-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-(cyclopropylsulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-(ethylsulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-((3-(ethyl(methyl)amino)propyl)sulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-((3-(dimethylamino)propyl)sulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-Isopropoxy-N-((3R,4S)-1-((3-(isopropyl(methyl)amino)propyl)sulfonyl)-3-methylpiperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-Isopropoxy-N-((3R,4S)-3-methyl-1-((3-(piperidine-1-yl)propyl)sulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-Isopropoxy-N-((3R,4S)-3-methyl-1-((3-(pyrrolidine-1-yl)propyl)sulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-((3-(diethylamino)propyl)sulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-Isopropoxy-N-((3R,4S)-3-methyl-1-((3-(4-methylpiperazine-1-yl)propyl)sulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-((3-(4-ethylpiperazine-1-yl)propyl)sulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 8-Isopropoxy-N-((3R,4S)-3-methyl-1-((4-morpholinobutyl)sulfonyl)piperidine-4-yl)-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-((4-((2,2-difluoroethyl)amino)butyl)sulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-((4-(ethyl(methyl)amino)butyl)sulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-((4-(dimethylamino)butyl)sulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, N-((3R,4S)-1-((4-((R)-3-(difluoromethyl)pyrrolidine-1-yl)butyl)sulfonyl)-3-methylpiperidine-4-yl)-8-isopropoxy-7-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-2-amine, 5-Isopropoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-Cyclobutoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-Isobutoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-propoxy-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-(2,2-difluoroethoxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-(2,2,3,3-tetrafluoropropoxy)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-Cyclopropoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-((3,3-difluorocyclopentyl)oxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-(cyclobutylmethoxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-(cyclopentylmethoxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-5-propoxy-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-Isobutoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-(2,2-difluoroethoxy)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-(2,2,3,3-tetrafluoropropoxy)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-(cyclopropylmethoxy)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-(piperidine-1-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-1-(ethylsulfonyl)-3-methylpiperidine-4-yl)-5-(piperidine-1-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-1-(cyclopropylsulfonyl)-3-methylpiperidine-4-yl)-5-(piperidine-1-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-3-methyl-1-((1-methyl-1H-imidazole-4-yl)sulfonyl)piperidine-4-yl)-5-(piperidine-1-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-Isopropoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-1-(ethylsulfonyl)-3-methylpiperidine-4-yl)-5-isopropoxy-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-1-(cyclopropylsulfonyl)-3-methylpiperidine-4-yl)-5-isopropoxy-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-((tetrahydro-2H-pyran-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-1-(ethylsulfonyl)-3-methylpiperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-((tetrahydro-2H-pyran-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-1-(cyclopropylsulfonyl)-3-methylpiperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-((tetrahydro-2H-pyran-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Cyclobutoxy-N-((3R,4S)-1-(ethylsulfonyl)-3-methylpiperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Cyclobutoxy-N-((3R,4S)-3-methyl-1-((1-methyl-1H-pyrazole-4-yl)sulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Cyclobutoxy-N-((3R,4S)-3-methyl-1-((1-methyl-1H-imidazole-4-yl)sulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-1-(ethylsulfonyl)-3-methylpiperidine-4-yl)-5-isopropoxy-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-1-(cyclopropylsulfonyl)-3-methylpiperidine-4-yl)-5-isopropoxy-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-((tetrahydro-2H-pyran-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, N-((3R,4S)-3-methyl-1-((1-methyl-1H-pyrazole-4-yl)sulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-((tetrahydro-2H-pyran-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyridine-2-amine, 5-Cyclobutoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Isobutoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-propoxy-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Butoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Isobutoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-5-propoxy-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Butoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-(3-methylcyclobutoxy)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(3-(difluoromethyl)cyclobutoxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Cyclopropoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-((4,4-difluorocyclohexyl)oxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-((3-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-((2-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-((2-(trifluoromethyl)tetrahydro-2H-pyran-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-((1-(trifluoromethyl)cyclobutyl)methoxy)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(cyclopropylmethoxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(isopentyloxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Cyclobutoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(3,3-difluorocyclobutoxy)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-((2-(trifluoromethyl)tetrahydro-2H-pyran-4-yl)oxy)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-((1-(trifluoromethyl)cyclobutyl)methoxy)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(isopentyloxy)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Ethoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(ethylthio)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(isopropylthio)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-(piperidine-1-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-5-(piperidine-1-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(3,3-difluoropiperidine-1-yl)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, (R)-5-(3-fluoropiperidine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, (S)-5-(3-fluoropiperidine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(3,3-difluoropyrroridine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(2-azabicyclo[2.2.1]heptan-2-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, (S)-5-(2-methylpiperidine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, (S)-5-(2-methylpyrrolidine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, (S)-5-(3-(difluoromethyl)pyrroridine-1-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-5-(3-(trifluoromethyl)piperidine-1-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-((propan-2-yl-2-d)oxy)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-((propan-2-yl-1,1,1,3,3,3-d ６ )oxy)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-5-((propan-2-yl-d ７ )oxy)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-(cyclopentyloxy)-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, 5-Isopropoxy-N-(1-(methylsulfonyl)piperidine-4-yl)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, and N-(1-(methylsulfonyl)piperidine-4-yl)-5-((propan-2-yl-2-d)oxy)-6-(1H-pyrazole-4-yl)-[1,2,4]triazolo[1,5-a]pyrazine-2-amine, A compound according to claim 1, or a pharmaceutically acceptable salt thereof, selected from the above.

40. A pharmaceutical composition comprising a compound according to any one of claims 1 to 39, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

41. A method for inhibiting CDK2, comprising contacting the CDK2 with a compound according to any one of claims 1 to 39, or a pharmaceutically acceptable salt thereof.

42. A method for inhibiting CDK2 in a patient, comprising administering to the patient a compound according to any one of claims 1 to 39, or a pharmaceutically acceptable salt thereof.

43. A method for treating a disease or disorder related to CDK2 in a patient, comprising administering to the patient a therapeutically effective amount of a compound according to any one of claims 1 to 39, or a pharmaceutically acceptable salt thereof.

44. The method according to claim 43, wherein the disease or disorder is related to amplification and / or overexpression of the cyclin E1 (CCNE1) gene.

45. A method for treating a human subject having a disease or disorder related to cyclin-dependent kinase 2 (CDK2), comprising administering to the human subject a compound according to any one of claims 1 to 39, or a pharmaceutically acceptable salt thereof, wherein the human subject (i) (a) Having a nucleotide sequence that encodes a p16 protein, including the amino acid sequence of Sequence ID No. 1, and / or (b) Having a cyclin-dependent kinase inhibitor 2A (CDKN2A) gene lacking one or more inactivating nucleic acid substitutions and / or deletions, (ii) (a) Having amplification of the cyclin E1 (CCNE1) gene, and / or (b) A biological sample obtained from the human subject having a CCNE1 expression level higher than the control CCNE1 expression level, The aforementioned method, which has been previously determined.

46. A method for treating a human subject with a disease or disorder related to cyclin-dependent kinase 2 (CDK2), (i) In the biological sample obtained from the human subject, (a) A nucleotide sequence encoding the p16 protein, including the amino acid sequence of Sequence ID No. 1, and / or (b) Identify the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene lacking one or more inactivating nucleic acid substitutions, (ii) In the biological sample obtained from the human subject, (a) amplification of the cyclin E1 (CCNE1) gene, and / or (b) Identify CCNE1 expression levels that are higher than the control expression level of CCNE1, (iii) Administering to a human subject a compound according to any one of claims 1 to 39, or a pharmaceutically acceptable salt thereof; The method, including the method described above.

47. (i) In the biological sample obtained from the human subject, (a) A nucleotide sequence encoding the p16 protein, including the amino acid sequence of Sequence ID No. 1, and / or (b) Identifying the CDKN2A gene lacking one or more inactivating nucleic acid substitutions and / or deletions, (ii) In the biological sample obtained from the human subject, (a) Identifying the amplification of the CCNE1 gene, (iii) Administering the compound or the salt to the human subject, The method according to claim 46, including the method described in claim 46.

48. A method for evaluating the response of a human subject having a disease or disorder related to cyclin-dependent kinase 2 (CDK2) to a compound according to any one of claims 1 to 39, or a pharmaceutically acceptable salt thereof, (a) administering the compound or salt to a human subject, wherein the human subject has been previously determined to have an amplified cyclin E1 (CCNE1) gene and / or a CCNE1 expression level higher than the control expression level of CCNE1, (b) Following the administration in step (a), the level of phosphorylation of the retinoblastoma (Rb) protein at serine corresponding to amino acid position 780 of SEQ ID NO: 3 in the biological sample obtained from the subject is measured, The method wherein a reduced level of Rb phosphorylation at the serine corresponding to amino acid position 780 of SEQ ID NO: 3, compared to a control level of Rb phosphorylation at the serine corresponding to amino acid position 780 of SEQ ID NO: 3, indicates that the human subject responds to the compound or the salt.

49. The method according to any one of claims 43 to 48, wherein the disease or disorder is cancer.

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