Drug-containing nanofibers
Drug-containing nanofibers using biodegradable polymers address L-dopa's wearing-off issue by enabling rapid, controlled delivery through the buccal and sublingual mucosa, ensuring consistent plasma levels and bypassing first-pass metabolism.
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- HOSHI UNIVERSITY
- Filing Date
- 2024-12-16
- Publication Date
- 2026-06-26
AI Technical Summary
L-dopa, a hydrophilic low-molecular-weight drug, experiences wearing-off effects when continuously taken, necessitating frequent dosage adjustments due to alternating effective and ineffective periods, and conventional oral and parenteral drug delivery methods are limited by permeability barriers and the first-pass effect.
Formulating drug-containing nanofibers using biodegradable or biocompatible polymers, particularly polyvinyl alcohol-based polymers, via electrospinning technology, to enable rapid drug delivery through the buccal and sublingual mucosa, ensuring amorphous drug state and controlled release.
The nanofibers facilitate rapid drug replenishment by delivering L-dopa systemically, mimicking oral administration onset, avoiding first-pass metabolism, and maintaining consistent plasma drug concentrations.
Smart Images
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