Oral components

Abstract

The present invention aims to provide an oral composition in which discoloration over time caused by pyridoxine or its salts is suppressed, and bitterness is reduced. [Solution] The present invention provides an oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: a fluorine-containing compound, wherein the content of component (A) is 0.11 to 0.95% by mass, and the content of component (B) is such that when converted to a fluoride ion concentration, it is 1000 to 20000 ppm, and preferably further comprising (C) component: at least one sweetener selected from the group consisting of saccharin sodium, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol.

Description

Technical Field

[0004] , , , , , ,

[0005]

[0001] The present invention relates to an oral composition.

Background Art

[0002] Pyridoxine (vitamin B6) or its salt is known to be incorporated into an oral composition as a component that can impart effects such as a periodontal disease preventive effect, more specifically, a short-chain fatty acid reducing effect, a glycation reaction inhibitory effect, a metabolism promoting effect, and an anti-inflammatory effect.

[0003] As an oral composition containing pyridoxine or its salt, for example, the following have been reported. Patent Document 1 describes an oral composition in which one or more selected from fluoride and one or more selected from the group consisting of pyridoxine and its derivatives are blended to further enhance the caries preventive effect. Patent Document 2 describes an oral composition that stably contains pyridoxine or its salt.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, in order to further enhance the periodontal disease prevention effect of pyridoxine or its salts, it is necessary to increase the amount of pyridoxine or its salts in the oral composition. However, when the amount is increased, there is a problem that the oral composition may change color over time. The inventions described in Patent Documents 1 and 2 can prevent periodontal disease and exert a periodontal disease prevention effect, but the pyridoxine or its salt content is high, and the oral composition may change color over time or exhibit a bitter taste. As a means of solving this problem, after various investigations, we found that by incorporating a fluorine-containing compound, discoloration of oral compositions caused by pyridoxine or its salts can be suppressed.

[0006] The present invention aims to provide an oral composition in which discoloration over time caused by pyridoxine or its salts is suppressed, and bitterness is reduced. [Means for solving the problem]

[0007] The present invention provides the following [1] to [6]. [1] An oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: a fluorine-containing compound, wherein the content of (A) is 0.11 to 0.95% by mass, and the content of (B) is such that, when converted to a fluoride ion concentration, it is 1,000 to 20,000 ppm. [2] The oral composition according to [1], further comprising (C) component: at least one sweetener selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol. [3] The oral composition according to [2], wherein the content of component (C) is 0.01 to 10% by mass. [4] The oral composition according to any one of [1] to [3], further comprising (D) component: at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate. [5] The oral composition according to [4], wherein the content of component (D) is 0.03 to 2% by mass. [6] An oral composition according to any one of items [1] to [5], wherein the ratio of the content (mass%) of component (A) to the content (ppm) of component (B) as a fluoride ion concentration, multiplied by 1000, is 0.005 to 0.42. [Effects of the Invention]

[0008] According to the present invention, it is possible to provide an oral composition in which discoloration over time caused by pyridoxine or its salts is suppressed, and bitterness is also reduced. [Modes for carrying out the invention]

[0009] <Oral composition> The oral composition of the present invention contains component (A) and component (B). Preferably, it may further contain at least one component from component (C) and component (D). In addition, if necessary, other known additives may be added in addition to the above components, as long as they do not interfere with the effects of the present invention.

[0010] [(A) component] (A) The component is pyridoxine or a salt thereof. By including component (A), the oral composition can be given a periodontal disease prevention effect.

[0011] In this embodiment, the pyridoxine salt is not particularly limited as long as it is a pharmaceutically acceptable salt that exhibits the effects described above. Examples of pyridoxine salts include pyridoxine hydrochloride, pyridoxine sulfate, pyridoxine nitrate, pyridoxine hydrobromide, and pyridoxine phosphate, among which pyridoxine hydrochloride is preferred.

[0012] Here, pyridoxine hydrochloride (pyridoxine hydrochloride) is the hydrochloride salt of pyridoxine and is a type of vitamin B6. (A) Component may be used individually or in combination of two or more of the above. In addition, commercially available products may be used for component (A).

[0013] [(B) Component] Component (B) is a fluorine-containing compound. By including component (B), it is possible to suppress the discoloration of the oral composition over time caused by component (A).

[0014] Fluorine-containing compounds are components that supply fluoride ions to oral compositions. In this embodiment, the fluorine-containing compounds that can be used are not particularly limited. Examples of fluorine-containing compounds include metal fluorides such as alkali metals, monofluorophosphates, or salts thereof. Of these, one or more selected from sodium fluoride, sodium monofluorophosphate, and stannous fluoride are preferred, and one or more selected from sodium fluoride and sodium monofluorophosphate are more preferred. Component (B) may be one of the above-mentioned components used alone, or two or more may be used in combination. Furthermore, commercially available products may be used for component (B).

[0015] [(C) component] Component (C) is at least one sweetener selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol. Of these, component (C) is preferably sodium saccharin and xylitol, and more preferably sodium saccharin. By including component (C), it is possible to improve the unpleasant taste that may occur when a combination of components (A) and (B) is included. Component (C) may be used individually or in combination of two or more of the above. Furthermore, commercially available products may be used for component (C).

[0016] [(D) component] (D) component is at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate. Examples of tocopherol acetate and tocopherol nicotinate include d-α-tocopherol acetate, dl-α-tocopherol acetate, d-α-tocopherol nicotinate, and dl-α-tocopherol nicotinate. Among these, as the (D) component, d-α-tocopherol acetate, dl-α-tocopherol acetate, and dl-α-tocopherol nicotinate are preferred, it is more preferred to use dl-α-tocopherol acetate and / or dl-α-tocopherol nicotinate, and it is even more preferred to use dl-α-tocopherol acetate. By containing the (D) component, when the oral composition of the present invention contains the combination of the (A) component and the (B) component, the unpleasant taste that may occur can be improved. (D) component may be used alone or in combination of two or more of the above. Also, commercially available products can be used as the (D) component.

[0017] The oral composition of the present invention contains the (A) component and the (B) component. Further, from the viewpoint of more effectively suppressing the unpleasant taste that may occur with the blending of the (A) component and the (B) component, the oral composition of the present invention preferably further contains at least one of the (C) component and the (D) component, and more preferably can further contain the combination of the (C) component and the (D) component.

[0018] [Content of each component] -(A) component- The content of component (A) is 0.11% by mass or more, preferably 0.13% by mass or more, based on the total amount of the composition of the present invention. Thereby, a sufficient periodontal disease prevention effect can be obtained. The upper limit is 0.95% by mass or less, preferably 0.8% by mass or less, 0.6% by mass or less, 0.5% by mass or less, more preferably 0.4% by mass or less, 0.3% by mass or less, or 0.2% by mass or less. Thereby, discoloration caused by component (A) can be improved by component (B), and it is possible to prevent adverse effects on usability such as the generation of bitterness after toothbrushing. Therefore, the content of component (A) is 0.11 to 0.95% by mass, preferably 0.11 to 0.8% by mass, 0.11 to 0.6% by mass, 0.11 to 0.5% by mass, more preferably 0.11 to 0.4% by mass, 0.11 to 0.3% by mass, or 0.13 to 0.2% by mass, based on the total amount of the composition of the present invention.

[0019] -Component (B)- The content of component (B) is 1000 ppm or more when converted to a fluoride ion concentration, preferably 1100 ppm or more, or 1200 ppm or more, and more preferably 1300 ppm or more, or 1400 ppm or more. This improves discoloration caused by component (A). The upper limit is 20000 ppm or less, preferably 18000 ppm or less, 16000 ppm or less, 14000 ppm or less, or 10000 ppm or less, and more preferably 8000 ppm or less, 6000 ppm or less, 5000 ppm or less, 3000 ppm or less, or 2000 ppm or less. This prevents bitterness from being produced due to the taste derived from component (B), and prevents the unpleasant taste during use that may occur when combined with component (A) from becoming too strong, thereby improving the unpleasant taste during tooth brushing caused by component (C) or (D). Therefore, the content of component (B), when converted to a fluoride ion concentration, is 1000 to 20000 ppm, preferably 1100 to 18000 ppm, 1100 to 16000 ppm, 1100 to 14000 ppm, or 1200 to 10000 ppm, and more preferably 1200 to 8000 ppm, 1200 to 6000 ppm, 1200 to 5000 ppm, 1300 to 3000 ppm, or 1400 to 2000 ppm.

[0020] -(A) / (B)×1000- The ratio of the content of component (A) (mass%) to the content of component (B) (ppm) multiplied by 1000 (hereinafter referred to as "(A) / (B) × 1000") is preferably 0.005 or higher, or 0.011 or higher, and more preferably 0.018 or higher, or 0.02 or higher. This helps to further prevent the deterioration of bitterness derived from components (A) and (B). The upper limit is preferably 1 or less, 0.98 or less, or 0.42 or less, and more preferably 0.4 or less, 0.3 or less, or 0.25 or less. This helps to further prevent a decrease in the discoloration-inhibiting effect of component (A). Therefore, the ratio (A) / (B) × 1000 is preferably 0.005 to 1, 0.005 to 0.98, or 0.011 to 0.42, and more preferably 0.018 to 0.4, 0.02 to 0.3, or 0.02 to 0.25.

[0021] -(C) component- The content of component (C) is not particularly limited, but is preferably 0.005% by mass or more, or 0.01% by mass or more, more preferably 0.015% by mass or more, 0.02% by mass or more, and even more preferably 0.05% by mass or more, relative to the total amount of the composition of the present invention. This can improve the unpleasant taste that may occur during brushing due to the blending of components (A) and (B), and can further improve the unpleasant taste when used in combination with component (D). The upper limit is preferably 13% by mass or less, or 10% by mass or less, more preferably 7% by mass or less, 5% by mass or less, and even more preferably 2% by mass or less, or 1% by mass or less, or 0.5% by mass or less. This can prevent unpleasant taste from being caused by the taste derived from component (C). Therefore, the content of component (C) is preferably 0.005 to 13% by mass, or 0.01 to 10% by mass, and more preferably 0.015 to 7% by mass, 0.02 to 5% by mass, 0.02 to 2% by mass, 0.05 to 1% by mass, or 0.05 to 0.5% by mass, based on the total amount of the composition of the present invention.

[0022] -((A)+0.0001×(B)) / (C)- The ratio of the sum of the content of component (A) (mass%) and the content of component (B) (ppm) multiplied by 0.0001 to the content of component (C) (mass%) (hereinafter referred to as "((A) + 0.0001 × (B)) / (C)") is preferably 0.021 or more, or 0.025 or more, more preferably 0.042 or more, 0.05 or more, 0.1 or more, even more preferably 0.5 or more, or 1 or more. The upper limit is preferably 295 or less, 200 or less, 100 or less, 80 or less, or 60 or less, more preferably 40 or less, 25 or less, 20 or less, even more preferably 15 or less, or 10 or less. Therefore, the ratio ((A) + 0.0001 × (B)) / (C) is preferably 0.021 to 295, 0.021 to 200, 0.021 to 100, 0.025 to 80, or 0.025 to 60, more preferably 0.042 to 40, 0.042 to 25, 0.05 to 20, or 0.1 to 15, and even more preferably 0.5 to 15, or 1 to 10. This makes it possible to further improve the unpleasant taste that may occur during brushing due to the blending of components (A) and (B).

[0023] -(D) Component- The content of component (D) is not particularly limited, but is preferably 0.01% by mass or more, 0.02% by mass or more, or 0.03% by mass or more, more preferably 0.04% by mass or more, or 0.05% by mass or more. This can improve the unpleasant taste that may arise with the blending of components (A) and (B), and can further improve the unpleasant taste when used in combination with component (C). The upper limit is preferably 4% by mass or less, 3% by mass or less, or 2% by mass or less, more preferably 1.5% by mass or less, or 1% by mass or less. This prevents the unpleasant taste from being enhanced by the taste derived from component (D). Therefore, the content of component (D) is preferably 0.01 to 4% by mass, 0.02 to 3% by mass, or 0.03 to 2% by mass, more preferably 0.03 to 1.5% by mass, 0.04 to 1.5% by mass, or 0.05 to 1% by mass.

[0024] -((A)+0.0001×(B)) / (D)- The ratio of the sum of the content of component (A) (mass%) and the content of component (B) (ppm, 0.0001 times the amount) to the content of component (D) (mass%) (hereinafter referred to as "((A) + 0.0001 × (B)) / (D)") is preferably 0.1 or higher, more preferably 0.18 or higher, 0.21 or higher, or 0.25 or higher. The upper limit is preferably 98 or lower, 70 or lower, 50 or lower, or 20 or lower, more preferably 18 or lower, 16 or lower, even more preferably 12 or lower, or 6 or lower. Therefore, the ratio ((A) + 0.0001 × (B)) / (D) is preferably 0.1 to 98, 0.1 to 70, 0.1 to 50, or 0.1 to 20, more preferably 0.18 to 18, 0.21 to 16, and even more preferably 0.25 to 12, or 0.25 to 6. This makes it possible to further improve the unpleasant taste that may occur during brushing due to the combination of components (A) and (B).

[0025] [Optional ingredients] The oral composition of this embodiment may contain optional components other than those already described, provided that the effects of the present invention are not impaired. These will be described in detail below.

[0026] Optional components, when the oral composition is a toothpaste composition (paste, gel, or cream toothpaste and toothpaste paste), include, for example, solvents, surfactants, sweeteners, fragrances, medicinal ingredients, oily ingredients, preservatives, humectants, abrasives, binders, pH adjusters, and colorants (pigments). These will be explained in detail below.

[0027] In this specification, the content of each component is based on the amount of each component used when manufacturing the oral composition.

[0028] -solvent- The oral composition of this embodiment may further contain a solvent. Preferably, water (purified water) or ethanol can be used as the solvent. The solvent may be one of the above solvents alone, two or more solvents in combination, or a commercially available product may be used.

[0029] - Surfactants - Examples of surfactants include nonionic surfactants, amphoteric surfactants, anionic surfactants, or cationic surfactants.

[0030] Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene alkyl ethers, glycerin fatty acid esters, polyglycerin fatty acid esters, alkyl glycosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, sucrose fatty acid esters (e.g., sucrose stearate, sucrose palmitate), sugar alcohol fatty acid esters (e.g., maltitol fatty acid ester, lactitol fatty acid ester), fatty acid ethanolamides (e.g., lauric acid mono or diethanolamide), polyoxyethylene polyoxypropylene block copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is preferably 5 to 100 moles, more preferably 5 to 60 moles. The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ether is preferably 10 to 26, and the average number of moles of ethylene oxide added is preferably 2 to 50 moles. The number of carbon atoms in the fatty acid of polyglycerin fatty acid ester is preferably 10 to 20, and the average degree of polymerization of glycerin is preferably 1 to 20. The average number of moles of ethylene oxide added to polyoxyethylene-polyoxypropylene alkyl ether is preferably 10 to 300 moles, the average number of moles of propylene oxide added is preferably 5 to 70 moles, and the number of carbon atoms in the alkyl group is preferably 10 to 20. The number of carbon atoms in the alkyl group of alkyl glycoside is preferably 8 to 20. The number of carbon atoms in the fatty acid of sucrose fatty acid ester is preferably 8 to 20. The number of carbon atoms in the fatty acid of sorbitan fatty acid ester is preferably 10 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is preferably 12 to 18, and the average number of moles of ethylene oxide added is preferably 20 to 80 moles. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14.

[0031] Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine), fatty acid amidopropyl betaine (e.g., coconut oil fatty acid amidopropyl betaine, cocamidopropyl betaine), and alkyl betaine (e.g., lauryl betaine, stearyl betaine); and imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts (e.g., N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), coconut oil fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

[0032] Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, lauryl sulfoacetate, and polyoxyethylene alkyl sulfosuccinate. The alkyl and acyl groups may be linear or branched, saturated or unsaturated, and the number of carbon atoms is preferably 10 to 20, more preferably 12 to 18, and even more preferably 12 to 14. The average number of ethylene oxide added to the polyoxyethylene alkyl sulfosuccinate is preferably 1 to 9. The salt can be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples include inorganic base salts such as sodium salt, potassium salt, calcium salt, magnesium salt, and ammonium salt; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt, and diisopropylammonium salt; and basic amino acid salts such as arginine salt. In particular, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0033] Examples of alkyl sulfates include lauryl sulfate (e.g., sodium lauryl sulfate) and myristoyl sulfate. Examples of acyl amino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamate salts such as lauroyl glutamate, myristoyl glutamate, and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methylglycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-methyl-N-acyl alanine salt; and acyl aspartate salts such as lauroyl aspartate salt. Examples of acyl taurine salts include lauroyl methyl taurine salt, N-methyl-N-acyl taurine salt, and N-cocoyl methyl taurine salt. Examples of α-olefin sulfonates include α-olefin sulfonates with 12 to 18 carbon atoms, such as tetradecene sulfonate. The number of carbon atoms in the alkyl group is preferably 12 to 14. Examples of the salt include sodium salt, potassium salt, and ammonium salt, with sodium salt being preferred. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate and sodium lauryl sulfoacetate.

[0034] Examples of cationic surfactants include quaternary ammonium salt type cationic surfactants and amino acid-based cationic surfactants. Examples of quaternary ammonium salts include alkylpyridinium salts, benzethonium salts, benzalkonium salts, monoalkyltrimethylammonium salts, and dialkyldimethylammonium salts. Examples of salts include chloride salts and bromide salts. Examples of alkyl groups in alkylpyridinium salts, monoalkyltrimethylammonium salts, or dialkyldimethylammonium salts include alkyl groups with 8 to 22 carbon atoms. The upper or lower limit of the number of carbon atoms may be, for example, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21. More specifically, it may be, for example, 9 to 21. Examples of quaternary ammonium salt type cationic surfactants include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, distearyldimethylammonium chloride, laurylbenzyldimethylammonium chloride, hexadecyltrimethylammonium bromide, and stearyltrimethylammonium bromide. Examples of amino acid-based cationic surfactants include mono-N-long-chain acyl basic amino acid lower alkyl ester salts. Examples of basic amino acids constituting amino acid-based cationic surfactants include natural amino acids such as ornithine, lysine, and arginine. Synthetic amino acids such as α,γ-diaminobutyric acid can also be used. These may be optically active or racemic. The acyl group of the mono-N-long-chain acyl basic amino acid lower alkyl ester salt is preferably a saturated or unsaturated higher fatty acid residue having 8 to 22 carbon atoms. The upper or lower limit of the carbon number may be, for example, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21. More specifically, it may be 9 to 21. Examples include single higher fatty acid residues such as lauroyl group, myristoyl group, palmitoyl group, and stearoyl group; and natural mixed higher fatty acid residues such as coconut oil fatty acid residues and beef tallow higher fatty acid residues. Examples of lower alkyl esters include alkyl esters having 1 to 8 carbon atoms. Specifically, these include methyl esters, ethyl esters, propyl esters, butyl esters, pentyl esters, hexyl esters, heptyl esters, octyl esters, and the like. Lower alkyl esters are preferably in salt form, and examples include inorganic salts such as hydrochloride, bromate, sulfate, and phosphate; and organic salts such as glycolate, acetate, lactate, succinate, tartrate, citrate, acidic amino acid salts, higher fatty acid salts, L- or DL-pyrrolidone carboxylate salts, pyroglutamate, and p-toluenesulfonate. Examples of amino acid-based cationic surfactants include N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate. The surfactant may be used individually from the above-mentioned types, or in combination of two or more types, and commercially available products may be used.

[0035] The surfactant content is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more, when the total amount of the oral composition is taken as 100% by mass. The upper limit is preferably 15% by mass or less, more preferably 10% by mass or less, and even more preferably 5.5% by mass or less. Therefore, the surfactant content is preferably 0.001 to 15% by mass, more preferably 0.01 to 10% by mass, and even more preferably 0.1 to 5.5% by mass, when the total amount of the oral composition is taken as 100% by mass.

[0036] -Sweetener- The oral composition of this embodiment may contain a conventionally known, optionally suitable sweetener in an optionally suitable amount. Including a sweetener in the oral composition can further improve the user experience.

[0037] Other sweeteners besides component (C) may be used. Examples include aspartame, stevioside, stevia extract, p-methoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartin, thaumatin, and aspartylphenylalanine methyl ester. One of the above-mentioned sweeteners may be used alone, or two or more may be used in combination. When using a sweetener, the amount can be appropriately determined within a range that does not impair the effects of the present invention. The sweeteners may be one of the above-mentioned types used alone, or two or more types used in combination, and commercially available products may be used.

[0038] -Fragrance- The oral composition of this embodiment may contain a conventionally known and suitable fragrance in an arbitrarily suitable amount. Including a fragrance in the oral composition can further improve the user experience.

[0039] Fragrances include, for example, natural essential oils such as peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, clove oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, rose oil, iris oil, thyme oil, sage oil, cardamom oil, coriander oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, grapefruit oil, lime oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, paraclete oil, vanilla oil, cinnamon oil, pimento oil, cinnamon leaf oil, and perilla oil; menthol, menthofran, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate Fragrance components contained in the above natural essential oils, such as phosphate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, octanal, octyl acetate, caryophyllene, germacrene, viridiflorol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, carone, methyl jasmonate, citronellyl acetate, ethyl linalool, etc.Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, ethylcyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, cis-3-hexenol, trans-2-hexenal, undecalact Fragrance components such as decalactone, hexyl acetate, ethyl-2-methyl butyrate, benzyl alcohol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl lactate, ethylene glycol-l-menthyl carbonate, maltol, ethyl maltol; plant extracts such as vanilla extract, chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, cardamom extract;This also includes various blended flavors such as mint, fruit, and herb, which are created by combining several fragrance components and natural essential oils. Furthermore, fragrances that can also function as cooling agents include, for example, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), N-[(ethoxycarbonyl)methyl)-p-menthane-3-carboxamide, Np-benzeneacetonitrile menthanecarboxamide, N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl lactate, menthyl monosuccinate, vanillyl butyl ether, isopuregol, menthol glycoside ketal, N-(4-cyanomethylphenyl)- Other examples include p-menthanecarboxamide, 3-l-menthoxypropane-1,2-diol, menthyl glyceryl ether, menthyl succinate, linalool oxide, vanillyl butyl ether, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, 2-isopropyl-N,2,3-trimethylbutylamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, menthyl glutarate, 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophen-2-ylmethyl)acetamide, and isopulegol. As for the fragrance, one of the fragrances exemplified above may be used alone, or two or more may be used in combination; commercially available products may be used. Furthermore, solvents may be used when compounding these fragrances. Examples of solvents include ethanol, propylene glycol, glycerin fatty acid esters, and triacetin. If the oral composition contains a fragrance, its content is preferably 0.0000001 to 5% by mass, more preferably 0.00001 to 3% by mass, and even more preferably 0.01 to 2% by mass, based on 100% by mass of the total amount of the oral composition. If the oral composition contains a fragrance that can also function as a cooling agent, its content is preferably 0.00001 to 0.01% by mass, based on 100% by mass of the total amount of the oral composition.

[0040] -Medicinal ingredients- Medicinal ingredients include, for example, enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, azulene, sodium azulene sulfonate, glycyrrhizic acid or its salts (e.g., dipotassium glycyrrhizate), glycyrrhetinic acid or its salts (e.g., stearyl glycyrrhetinate), Phellodendron bark, and Phellodendron bark extract; cell activators such as sodium chloride and vitamins; isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, thymol, lysozyme chloride, chlorhexidine, triclosan, and glycan. Examples of medicinal ingredients include: bactericidal or antibacterial agents such as zinc conate and zinc citrate; water-soluble copper compounds such as copper chlorophyll and copper gluconate; tartar preventative agents such as zeolite, ethane hydroxydiphosphonate, and polyphosphates (e.g., sodium polyphosphate); vitamins such as vitamin C (e.g., ascorbic acid) and vitamin E other than component (D) (e.g., tocopherol); astringents such as sodium chloride, alum, and lysozyme chloride; hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; amino acids such as alanine, glycine, proline, arginine, lysine, glutamine, and cysteine; peptides such as caropeptide; and plant extracts such as thyme, scutellaria baicalensis, clove, and witch hazel. When an oral composition contains medicinal ingredients, the amount can be an effective amount within a range that does not hinder the effects of the present invention (a range that is pharmacologically acceptable). The medicinal ingredients may be one of the above-mentioned ingredients used alone, or two or more ingredients may be used in combination, and commercially available products may be used.

[0041] -Oily components- Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. The oily component may be one of the above-mentioned types used alone, or two or more types used in combination, and commercially available products may be used.

[0042] - Preservatives - The oral composition of this embodiment may contain a conventionally known, suitable preservative in a suitably appropriate amount. By including a preservative in the oral composition, the preservative effect of the oral composition can be ensured.

[0043] Examples of preservatives that may be included in oral compositions include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, etc. The preservatives may be used individually or in combination of two or more, and commercially available products may be used.

[0044] -Wetting agent- The oral composition of this embodiment may contain a conventionally known and suitable wetting agent in an arbitrarily suitable amount. By including an arbitrary wetting agent in the oral composition, the user experience can be further improved.

[0045] As a wetting agent, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include sorbitol, lactitol, and reduced starch syrups; glycerin; and polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycol include polyethylene glycol with an average molecular weight of 150 to 6000, preferably polyethylene glycol with an average molecular weight of 190 to 4000. Specifically, examples include PEG200, PEG300, PEG400, PEG600, and PEG4000. The average molecular weight is the average molecular weight described in the 2021 Japanese Standards for Raw Materials of Quasi-Drugs. The wetting agent may be used individually from the above list, or in combination of two or more, and commercially available products may be used. If the oral composition may contain a wetting agent, its content is preferably 1 to 70% by mass, more preferably 1 to 65% by mass, even more preferably 1 to 60% by mass, and most preferably 3 to 60% by mass, when the total amount of the oral composition is 100% by mass.

[0046] -Abrasive- As an abrasive, this embodiment can be suitably used when the oral composition is a toothpaste composition (toothpaste).

[0047] Examples of abrasives include calcium phosphate compounds such as dicalcium phosphate dihydrate and anhydrous phosphate, monocalcium phosphate, tricalcium phosphate, and calcium pyrophosphate; silica-based abrasives such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica; calcium carbonate, calcium hydroxide, aluminum hydroxide, trimagnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite. One or more of these can be blended. Among these, compounds mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, as well as calcium carbonate, are particularly preferred. Examples of precipitated silica include those with a particle size of 1 μm to 40 μm and a BET specific surface area of ​​10 to 250 square meters per gram, and commercially available precipitated silica can be blended. Examples include Zeodent 124, Zeodent 113, Zeodent 103, Sident 3, Sident 9, and Sident 20 from EVONIK, TIXOSIL 73 and TIXOSIL 63 from Rhodia, and zirconosilicate and aluminosilicate from Taki Chemical Co., Ltd. The amount of abrasive is preferably 5 to 70% by mass, and more preferably 10 to 50% by mass, when the total amount of the oral composition is 100% by mass. The abrasive may be one of the above-mentioned types used alone, or two or more types may be used in combination, and commercially available products can be used.

[0048] Furthermore, granular materials can be incorporated as abrasive components. The granular materials are granulated particles formed from water-insoluble powders. A binder may be used for granulation, but it is preferable not to use a binder. Examples of water-insoluble powders include inorganic powders such as dicalcium phosphate, tricalcium phosphate, water-insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, iron oxide, calcium carbonate, calcium pyrophosphate, zeolite, aluminosilicate, magnesium carbonate, zirconosilicate, and calcium sulfate, as well as mixtures thereof. Silica granules and zeolite granules are particularly preferred. The volume-average particle size (median diameter d50) of the granular material is preferably 50 to 500 μm. The volume-average particle size is measured using a particle size distribution analyzer (Microtrac particle size distribution analyzer, manufactured by Nikkiso Co., Ltd., dispersion medium: water). The average disintegration strength of the granular material is preferably 10 to 200 g / piece. In this invention, the average collapse strength is the average of the automatic fracture strength measurements of 30 granules using a rheometer (Sun Rheometer CR-200D, manufactured by Sun Science Co., Ltd.). (The value is the load measured when a granule collapses when it is compressed at a speed of 10 mm / min.) As silica granules, gel-processed silica and precipitated silica are preferably used, and a primary particle size of about 3 to 15 nm, preferably 4 to 10 nm, is good. For example, methods include washing and drying a mass of silica gel grown to a primary particle size of about 4 to 10 nm by the gel method, then pulverizing it to classify it into silica granules with an average particle size of 50 to 500 μm; spraying silica hydrosol into the air to gel it and preparing granules; and preparing silica granules by agglomerating while suppressing primary particle growth using the precipitated method, and then growing the primary particle size to about 4 to 10 nm. Silica granules can be prepared using these methods. Among these, the method of pulverizing a mass of silica gel prepared by the gel method is preferred because it is simple in terms of manufacturing and the average particle size can be easily controlled by classification. By preparing the granules in this way, it is possible to obtain granules with appropriate average collapse strength. Commercially available silica granules with such average particle size and average collapse strength can be used. Specific examples of silica granules include SORBOSILBFG10 and SORBOSILBFG50 from PQ Corporation, NIPGELAY and NIPGELBY-001 from Tosoh Silica, and SYLOPURE30, SYLOPURE39, SYLOPURE40, SYLOPURE50, and SYLOPURE60 from Fuji Silicia Chemical. An example of a zeolite granule is COLITETG from Cosmo. Colored granules can also be used, specifically SORBOSILBFG51, SORBOSILBFG52, and SORBOSILBFG54 from PQ Corporation. The amount of these granules added is preferably 0.1 to 20% by mass of the total composition.

[0049] - Binding agent - The oral composition of this embodiment may contain a binder.

[0050] Examples of binders that can be included in oral compositions include conventionally known and suitable organic binders, such as polysaccharides, cellulosic binders (e.g., carboxymethylcellulose (CMC) or its salts (e.g., sodium carboxymethylcellulose), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, etc., and pharmaceutically acceptable salts thereof such as their sodium salts), other polysaccharide thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Furthermore, inorganic binders such as thickening silica and aluminum silicate can also be included. One or more of the above-exemplary binders can be included as binders, and commercially available products can be used.

[0051] As the thickening silica, silica obtained by known manufacturing methods with an absorption capacity in the range of 2 to 5 ml / g can be used. The method for measuring the absorption capacity is as follows. Weigh 1.0 g of the sample onto a clean glass plate, and using a microburette, add 42.5% glycerin dropwise in small amounts while mixing the sample with a stainless steel spatula until the liquid is uniform. The endpoint is reached when the sample forms a single mass and can be cleanly peeled off the glass plate with the spatula, and the amount of liquid (ml) used is recorded as the absorption volume. Examples of thickening silica include Tokusil from Tokuyama Corporation, SORBOSILTC15 from PQ Corporation, TIXOSIL43 from Rhodia, Zeodent153 from EVONIK, Carplex #67Q from DSL Japan, and Silopure 25 from Fuji Silicia Chemical Co., Ltd.

[0052] The binder content is preferably greater than 0% by mass, more preferably 0.001% by mass or more, and more preferably 0.01% by mass or more, when the total amount of the oral composition is considered as 100% by mass. The upper limit is preferably 11% by mass or less, and more preferably 10% by mass or less. Therefore, the binder content is preferably greater than 0% by mass and 11% by mass or less, and more preferably 0.001 to 10% by mass, and more preferably 0.01 to 10% by mass.

[0053] - pH adjuster - The oral composition of this embodiment may contain a conventionally known and suitable pH adjusting agent in a suitably suitable amount. By including a pH adjusting agent in the oral composition, the pH stability of the oral composition can be ensured.

[0054] Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, tartaric acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate); inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic salts include disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, sodium carbonate, and sodium bicarbonate. pH adjusters may be used individually from the above-mentioned types, or in combination of two or more types, and commercially available products may be used.

[0055] The amount of pH adjuster can preferably be such that the pH of the oral composition after addition is 5 to 9, and more preferably 5.5 to 8.5.

[0056] In this specification, the pH value preferably refers to the value obtained 3 minutes after the start of measurement at 25°C. The pH value can be measured using, for example, a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

[0057] -Colorants- The oral composition of this embodiment may contain a conventionally known and suitable coloring agent in a suitably suitable amount.

[0058] Examples of colorants that may be included in an oral composition include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red yeast rice pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cocoa pigment, spirulina blue pigment, and tamarind pigment, as well as legally approved pigments such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1, and riboflavin, copper chlorophyll sodium, and titanium dioxide (titanium oxide). When an oral composition contains a colorant, its content is preferably 0.00001 to 3% by mass when the total amount of the oral composition is 100% by mass. The coloring agents may be one of the above-mentioned types used alone, or two or more types used in combination, and commercially available products may be used.

[0059] -Other optional components- The oral composition of this embodiment may contain other optional components in an optionally suitable amount.

[0060] In this embodiment, examples of other optional components that the oral composition may contain include inorganic compounds such as titanium mica, titanium dioxide, zinc oxide, magnesium oxide, and zirconium oxide; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; calcium compounds such as calcium glycerophosphate; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; and polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these other optional components can be appropriately set within a range that does not hinder the effects of the present invention. Other optional components may be used individually or in combination of two or more of the above-mentioned components, and commercially available products may be used.

[0061] [Dosage forms and uses of oral compositions] The oral composition of this embodiment can be prepared in any suitable conventional dosage form by any suitable conventional method according to the usual procedures. Examples of dosage forms include liquids (liquid bodies such as solutions, emulsions, suspensions, and syrups), semi-solids (gels, creams, pastes, etc.), and solids (tablets, particulates, capsules, films, kneaded products, molten solids, waxy solids, elastic solids, soft capsules, etc.). The dosage form of the oral composition is preferably a liquid or a semi-solid.

[0062] The oral compositions of this embodiment can be widely used in oral applications. Examples of solid dosage forms include lozenges, gummies, gums, and toothpastes. Examples of semi-solid dosage forms include toothpastes and gel toothpastes. Examples of liquid dosage forms include mouthwashes, liquid toothpastes, and oral fresheners (sprays, etc.).

[0063] In this embodiment, the oral composition preferably has a pH of 5 to 9 (at 25°C). The pH can be adjusted by adding a pH adjusting agent, changing the component composition, etc.

[0064] The oral composition of this embodiment can be adjusted to an appropriate viscosity depending on the dosage form, for example. In the case of an oral composition in paste or gel form, the viscosity at 25°C measured with a BH viscometer is preferably 1 Pa·s to 300 Pa·s, and more preferably 20 to 150 Pa·s.

[0065] [Method for producing oral compositions] The method for producing the oral composition of the present invention is not particularly limited. When the oral composition of the present invention is a toothpaste composition, it can be produced by any suitable conventionally known method. Specifically, a method for producing a toothpaste composition may involve first preparing components that dissolve in a solvent, then mixing in other insoluble components, and, if necessary, degassing by, for example, reducing pressure. The toothpaste obtained in this way can be made into a product by placing it in a designated container (laminated tube). The shape and material of the container in which the toothpaste composition of the present invention can be contained are not particularly limited. Any suitable conventionally known container that is normally applied to toothpaste compositions can be used as the container. Examples of containers include plastic containers made of polyethylene, polypropylene, polyethylene terephthalate, and nylon.

[0066] When the oral composition of the present invention is a liquid oral composition, one possible method of manufacturing it is to sequentially add raw material components to a solvent such as purified water, stir, and dissolve them uniformly. The shape and material of the container in which the liquid oral composition of the present invention can be contained are not particularly limited. It can be used by filling it into a container that is normally used for oral compositions. Specifically, such containers can be laminated containers consisting of a polyethylene layer, an ethylene methacrylic acid copolymer layer, a polyethylene terephthalate layer, an aluminum layer, a glass vapor deposition layer, a polyvinyl alcohol layer, an ethylene vinyl alcohol copolymer layer, an acrylonitrile copolymer layer, paper, a recycled plastic layer, etc., or polyethylene containers, polyethylene terephthalate containers, polypropylene containers, or pouch containers made of polyethylene or polypropylene such as linear polyethylene, low-density polyethylene, high-density polyethylene, etc. Various containers that are normally used for oral compositions can be used, such as tubular containers, mechanical or differential pressure dispenser containers, and film packaging containers such as pillow packaging. [Examples]

[0067] The present invention will be described below with reference to examples. The following examples are not intended to limit the present invention.

[0068] <Raw materials used> -(A) component- Pyridoxine hydrochloride: Manufactured by Kyowa Pharma Chemical Co., Ltd., "Pyridoxine hydrochloride" -(B) Component- Sodium fluoride: Stella Chemifa Co., Ltd., "Purified Sodium Fluoride (S)" Sodium monofluorophosphate: "PHOSKADENT Na 211" manufactured by ICL Japan Co., Ltd. Stannous fluoride: Manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., "Stin(II) fluoride" -(C) component- Sodium saccharin: Manufactured by Aisan Chemical Industry Co., Ltd., "Sodium saccharin" Xylitol: Mitsubishi Corporation Life Sciences Co., Ltd., "Xylitol" -(D) Component- Tocopherol acetate: Manufactured by DSM Nutrition Japan, "dl-α-tocopherol acetate" Tocopherol nicotinate: Manufactured by Eisai Food Chemical Co., Ltd., "Tocopherol Nicotinate" -others- 70% sorbitol: "D-Sorbitol Solution" manufactured by Mitsubishi Corporation Life Sciences Co., Ltd. Polyoxyethylene (POE) hydrogenated castor oil (20): "Brownon RCX-20" manufactured by Aoki Oil Co., Ltd. Sodium lauryl sulfate: Manufactured by BASF Japan Ltd., "TEXAPON OC-P" Sodium carboxymethylcellulose: CMC1260, manufactured by Daicel Mirise Co., Ltd. Silica (abrasive): Zeodent 124, manufactured by EVONIK Corporation. Propylene glycol: "Cosmetic-grade propylene glycol" manufactured by ADEKA Corporation. Fragrance compositions A to S: The composition of each fragrance composition is shown in Tables 6 and 7. purified water

[0069] <Evaluation of toothpaste composition> The raw materials shown in Tables 1-5 were blended by conventional methods to obtain toothpaste compositions. The obtained toothpaste compositions were then placed in any suitable conventionally known container (laminated tube).

[0070] The obtained toothpaste compositions (Examples 1-32 and Comparative Examples 1-4) were evaluated using the following evaluation method. The evaluation results are shown in Tables 1-5 below.

[0071] -Evaluation of discoloration over time- The toothpaste compositions described in the examples and comparative examples were visually observed and evaluated for their appearance (discoloration and its degree) after being stored for one month at 60°C and -5°C. Specifically, the discoloration (or lack thereof) of the toothpaste composition stored at 60°C for one month was evaluated using the following scoring criteria, with the toothpaste composition stored at -5°C for one month used as a baseline. The average score obtained from a total of five similar tests was calculated and evaluated using the following five-level evaluation criteria.

[0072] Rating criteria: 5 points: No discoloration at all. 4 points: There is a very slight discoloration to a pale yellow, but it is hardly noticeable. 3 points: There is a slight discoloration to a light yellow, but it is not noticeable during use. Two points: There is discoloration from dark yellow to brownish-red. 1 point: Discoloration to a dark reddish-brown color.

[0073] Evaluation criteria: A score of C or higher is considered a passing grade. A: Average score of 4.5 or higher B: Average score is between 4.0 and 4.5 C: Average score is between 3.0 and 4.0 D: Average score is between 2.0 and 3.0 points. E: Average score is less than 2.0 points

[0074] -Evaluation of bitterness after brushing teeth- Ten expert panelists conducted a sensory evaluation of the presence and degree of bitterness after brushing. Each toothpaste composition, according to the previously described examples and comparative examples, was dispensed 1 cm onto a toothbrush. Brushing was performed for 3 minutes using the usual method. The presence and degree of bitterness felt in the mouth after brushing were evaluated according to the scoring criteria shown below. The average score of the ten expert panelists was calculated and judged as A, B, C, or D according to the evaluation criteria below.

[0075] Rating Criteria 4 points: No bitterness at all. 3 points: Slightly bitter taste. 2 points: I can taste bitterness. 1 point: I find the bitterness to be very strong.

[0076] Evaluation criteria: A score of B or higher is considered a passing grade. A: Average score of 3.5 points or more B: Average score between 3.0 and 3.5 points C: Average score between 2.0 and 3.0 D: Average score between 1.0 and 2.0

[0077] - How to evaluate sarcastic remarks made while brushing your teeth - A sensory evaluation was conducted by 10 expert panelists to assess the presence and degree of unpleasant taste during toothbrushing. The toothpaste compositions described in the previously mentioned examples and comparative examples were applied to a toothbrush, extruding 1 cm of each. Teeth were brushed for 3 minutes using the usual method, and the presence and degree of unpleasant taste felt during brushing were evaluated according to the following scoring criteria. The average score from the 10 expert panelists was calculated and judged as A, B, C, D, or E according to the evaluation criteria below.

[0078] Rating Criteria 4 points: Not offensive at all. 3 points: Almost no sarcasm. 2 points: Slightly sarcastic. 1 point: It's sarcastic.

[0079] Evaluation criteria: A score of C or higher is considered a passing grade. A: Average score 4.0 points B: Average score of 3.5 points or higher but less than 4.0 points C: Average score of 3.0 or higher but less than 3.5 D: Average score between 2.0 and 3.0 E: Average score less than 2.0 points

[0080] [Table 1]

[0081] [Table 2]

[0082] [Table 3]

[0083] [Table 4]

[0084] [Table 5]

[0085] While the toothpaste compositions of Comparative Examples 1 to 4 were inferior in either discoloration over time or bitterness after brushing, the toothpaste compositions of the present invention in Examples 1 to 32, which contained predetermined amounts of component (A) and component (B), all showed suppressed discoloration over time and suppressed bitterness after brushing. Of these, the toothpaste compositions of the present invention (Examples 14-32) further containing at least one of component (C) and component (D) were also good in terms of the absence of unpleasant taste during brushing, and the toothpaste compositions of the present invention containing both component (C) and component (D) were more preferable in terms of the absence of unpleasant taste during brushing.

[0086] (Example prescription) Below are examples of formulations for oral compositions (toothpaste compositions) to which the present invention is applied. In each formulation example, the unit of the numerical value indicated as the content is "mass%". In the following prescription examples 1-43, discoloration over time was suppressed, and the bitter taste after brushing was also reduced. Furthermore, the evaluation results did not change even when fragrance composition A used in the oral compositions of Examples 1-32, Comparative Examples 1-4, and Formulation Examples 1-43 was replaced with fragrance compositions B-S.

[0087] Prescription Example 1 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Sodium lauryl sulfate: 1.5 Sodium lauroyl sarcosinate: 0.1 Polyoxyethylene (20) hydrogenated castor oil: 0.5 Sodium polyphosphate: 1 Abrasive silica*1:18 Thickening silica*2:3 Titanium dioxide: 0.4 Coconut oil fatty acid amidopropyl betaine solution*3:0.5 Propylene glycol: 4 Sodium bicarbonate: 0.2 70% sorbitol solution: 25 Xanthan gum: 1.6 Sodium polyacrylate: 0.2 Methylparaben: 0.2 Sodium hydroxide (48% solution): 0.2 Fragrance composition A:1.2 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0088] Prescription Example 2 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Sodium lauryl sulfate: 1 Sodium lauroyl sarcosinate: 0.1 Polyoxyethylene (20) hydrogenated castor oil: 1 Sodium pyrophosphate: 0.5 Abrasive silica*1:22 Thickening silica*2:1 Titanium dioxide: 0.4 Aluminum oxide: 2 Propylene glycol: 3 Polyethylene glycol 400:2.5 Sodium bicarbonate: 0.5 70% sorbitol solution: 30 Xanthan gum: 0.8 Sodium polyacrylate: 0.5 Methylparaben: 0.2 Sodium hydroxide (48% solution): 0.2 Fragrance composition A:1.2 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3)

[0089] Prescription Example 3 Pyridoxine hydrochloride: 0.2 Stannous fluoride: 0.6 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.1 Mannitol: 0.5 Sodium lauryl sulfate: 1.5 Heavy calcium carbonate: 50 Thickening silica*1:2 Aluminum oxide: 1 Polyethylene glycol 400:1 Propylene glycol: 3 70% sorbitol solution: 20 Sodium carboxymethylcellulose*2:1 Methylparaben: 0.2 Fragrance composition A:1 Water: Balance Total: 100 *1 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *2 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0090] Prescription Example 4 Pyridoxine hydrochloride: 0.2 Sodium monofluorophosphate: 1.1 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Sucralose: 0.002 Sodium lauryl sulfate: 1.8 Heavy calcium carbonate: 35 Thickening silica*4:5 Propylene glycol: 3 70% sorbitol solution: 25 Sodium carboxymethylcellulose*1:0.6 Sodium carboxymethylcellulose*2:0.2 Sodium carboxymethylcellulose*3:0.4 Sodium polyacrylate: 0.2 Methylparaben: 0.2 Fragrance composition A:1 Water: Balance Total: 100 *1 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *2 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260 *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1250 *4 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1220

[0091] Prescription Example 5 Pyridoxine hydrochloride: 0.2 Sodium monofluorophosphate: 1.1 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Xylitol: 7 Mannitol: 0.3 Sodium lauryl sulfate: 2 Sodium lauroyl sarcosinate: 0.1 Heavy calcium carbonate: 20 Aluminum oxide: 0.4 Thickening silica*1: 5.5 Titanium dioxide: 0.5 70% sorbitol solution: 25 Propylene glycol: 3 Sodium carboxymethylcellulose*2:1.5 Methylparaben: 0.2 Fragrance composition A: 1.5 Water: Balance Total: 100 *1 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *2 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0092] Prescription Example 6 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.15 Mannitol: 0.2 Sucralose: 0.02 Sodium tetradecenesulfonate: 0.3 Sodium lauryl sulfate: 0.3 Polyoxyethylene (20) hydrogenated castor oil: 1.5 Abrasive silica*1:15 Thickening silica*2:5 Titanium dioxide: 0.4 Coconut oil fatty acid amidopropyl betaine: 1.5 70% sorbitol solution: 40 Propylene glycol: 3 Polyethylene glycol 4000:0.2 Xanthan gum: 0.5 Sodium alginate: 0.5 Sodium polyacrylate: 0.2 Hydroxyethylcellulose dimethyldiallylammonium chloride: 0.05 Benzalkonium chloride: 0.01 Fragrance composition A:1 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.7)

[0093] Prescription example 7 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Mannitol: 0.2 Sodium lauryl sulfate: 0.7 Sodium tetradecenesulfonate: 0.3 Sodium lauroyl sarcosinate: 0.2 Polyoxyethylene (20) hydrogenated castor oil: 1 Polyoxyethylene (5) stearyl ether: 1 Decaglycerin fatty acid ester: 0.2 Dextranase*1:0.2 (Enzyme activity per gram of preparation: 20 U): Sodium polyphosphate: 0.5 Polishable silica*2:18 Thickening silica*3:6 Titanium oxide: 1 Coconut oil fatty acid amidopropyl betaine: 2 70% sorbitol solution: 40 Propylene glycol: 3 Polyethylene glycol #4000:1 Xanthan gum: 0.5 Carrageenan: 0.5 Sodium alginate: 0.2 Hydroxyethylcellulose dimethyldiallylammonium chloride: 0.05 DL-Alanine: 0.15 Fragrance composition A: 1.3 Water: Balance Total: 100 *1 Dextranase: Mitsubishi Chemical Corporation Dextranase 2F (enzyme activity 4000 U / g) *2 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *3 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.7)

[0094] Prescription example 8 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.1 Mannitol: 0.5 Tocopherol acetate: 0.1 Dextranase*1:0.2 (Enzyme activity per gram of preparation: 20 U): Potassium nitrate: 5 Sodium lauryl sulfate: 0.5 Sodium lauroyl sarcosinate: 0.1 Sodium tetradecenesulfonate: 0.5 Polyoxyethylene (20) hydrogenated castor oil: 2 Polyoxyethylene(5) stearyl ether: 1.5 Decaglycerin fatty acid ester: 0.1 Polishable silica*2:10 Thickening silica*3:1 Thickening silica*4:2 Titanium dioxide: 0.4 Coconut oil fatty acid amidopropyl betaine: 2 Propylene glycol: 5 70% sorbitol solution: 45 Xanthan gum: 1 Sodium alginate: 0.8 Sodium polyacrylate: 0.6 Hydroxyethylcellulose Dimethyldiallylammonium Chloride:1 Sodium pyrrolidonecarboxylate: 3 DL-Alanine: 0.1 Fragrance composition A: 1.3 Water: Balance Total: 100 *1 Dextranase: Mitsubishi Chemical Corporation Dextranase 2F (enzyme activity 4000 U / g) *2 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *3 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.7) *4 Thickening silica: Nippon Aerosil Co., Ltd. Aerosil 200 (liquid absorption capacity 4.2)

[0095] Prescription example 9 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.12 Xylitol: 3 Mannitol: 0.3 Tocopherol acetate: 0.1 Potassium nitrate: 5 Dextranase*1:0.2 (Enzyme activity per gram of preparation: 20 U): Sodium lauroyl sarcosinate: 0.1 Sodium tetradecenesulfonate: 1 Polyoxyethylene (20) hydrogenated castor oil: 2.5 Polyoxyethylene(5) stearyl ether: 1.5 Decaglycerin fatty acid ester: 0.1 Coconut oil fatty acid amidopropyl betaine: 1 Polishable silica*2:10 Thickening silica*3:2 Thickening silica*4:0.5 Titanium dioxide: 0.4 Propylene glycol: 5 70% sorbitol solution: 45 Xanthan gum: 1.5 Sodium alginate: 0.2 Sodium polyacrylate: 0.2 Hydroxyethylcellulose dimethyldiallylammonium chloride: 0.1 DL-Alanine: 0.2 Fragrance composition A: 1.3 Water: Balance Total: 100 *1 Dextranase: Mitsubishi Chemical Corporation Dextranase 2F (enzyme activity 4000 U / g) *2 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *3 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.7) *4 Thickening silica: Nippon Aerosil Co., Ltd. Aerosil 200 (liquid absorption capacity 4.2)

[0096] Prescription example 10 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Sodium lauryl sulfate: 1.4 Sodium lauroyl sarcosinate: 0.2 Polyoxyethylene (20) hydrogenated castor oil: 0.5 Polyoxyethylene(5) stearyl ether: 0.5 β-Glycyrrhetinic acid: 0.01 Isopropylmethylphenol: 0.1 Abrasive silica*1:15 Thickening silica*2:5 Titanium dioxide: 0.1 70% sorbitol solution: 35 Propylene glycol: 3 Polyethylene glycol 4000:0.5 Xanthan gum: 0.7 Sodium alginate: 0.3 Sodium polyacrylate: 0.5 Fragrance composition A: 1.3 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.4L)

[0097] Prescription Example 11 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.18 Xylitol: 0.5 Sodium lauryl sulfate: 1.2 Polyoxyethylene (20) hydrogenated castor oil: 0.75 Polyoxyethylene(5) stearyl ether: 0.75 β-Glycyrrhetinic acid: 0.01 Isopropylmethylphenol: 0.05 Abrasive silica*1:15 Thickening silica*2:5 Titanium dioxide: 0.4 70% sorbitol solution: 35 Sodium carboxymethylcellulose*3:1.4 Sodium polyacrylate: 0.4 Fragrance composition A:1.2 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.4L) *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0098] Prescription Example 12 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.18 Tocopherol acetate: 0.2 Tranexamic acid: 0.05 Isopropylmethylphenol: 0.05 Sodium lauroyl methyl taurate: 0.6 Sodium lauryl sulfate: 0.2 Polyoxyethylene (5) hydrogenated castor oil: 1.5 Polishable silica*1:10 Thickening silica*2:6 Titanium dioxide: 0.05 Coconut oil fatty acid amidopropyl betaine: 0.3 85% Glycerin: 40 Xanthan gum: 0.5 Sodium carboxymethylcellulose*3:1.5 Sodium polyacrylate: 0.3 Citric acid: 0.5 Sodium citrate: 0.5 Anhydrous sodium sulfate: 0.5 Fragrance composition A: 1.3 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.4L) *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0099] Prescription Example 13 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Xylitol: 1 Sucralose: 0.005 Tocopherol acetate: 0.1 Tranexamic acid: 0.05 Isopropylmethylphenol: 0.05 Dipotassium glycyrrhizinate: 0.1 Sodium lauroyl methyl taurate: 0.8 Sodium lauryl sulfate: 0.1 Polyoxyethylene (5) hydrogenated castor oil: 1.5 Polishable silica*1:10 Thickening silica*2: 4.5 Titanium dioxide: 0.01 Coconut oil fatty acid amidopropyl betaine: 0.6 85% Glycerin: 20 70% sorbitol solution: 20 Xanthan gum: 0.2 Sodium carboxymethylcellulose*3:1.8 Sodium polyacrylate: 0.3 Citric acid: 0.5 Sodium citrate: 0.5 Anhydrous sodium sulfate: 1 Fragrance composition A: 1.3 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0100] Prescription Example 14 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.18 Tocopherol acetate: 0.1 Potassium nitrate: 5 Tranexamic acid: 0.05 Isopropylmethylphenol: 0.05 Sodium lauroyl methyl taurate: 0.7 Polyoxyethylene (5) hydrogenated castor oil: 2 Polishable silica*1:8 Titanium dioxide: 0.5 Thickening silica*3:6 Coconut oil fatty acid amidopropyl betaine: 1 70% sorbitol solution: 40 Sodium carboxymethylcellulose*2:2 Xanthan gum: 0.5 Citric acid: 0.25 Sodium citrate: 0.5 Fragrance composition A: 1.3 Methylparaben: 0.2 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0101] Prescription example 15 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.15 Tocopherol acetate: 0.1 Sodium polyphosphate: 1 Tranexamic acid: 0.05 Isopropylmethylphenol: 0.05 Sodium lauroyl methyl taurate: 1.5 Polyoxyethylene (5) hydrogenated castor oil: 1.5 Abrasive silica*1:12 Thickening silica*2:2 Titanium dioxide: 0.4 Coconut oil fatty acid amidopropyl betaine: 2 70% sorbitol solution: 50 Sodium carboxymethylcellulose*3:1.5 Sodium polyacrylate: 0.5 Fragrance composition A: 1.3 Methylparaben: 0.2 Anhydrous sodium sulfate: 1 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0102] Prescription Example 16 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.15 Tocopherol acetate: 0.1 Tranexamic acid: 0.05 Potassium nitrate: 5 Isopropylmethylphenol: 0.05 Sodium polyphosphate: 1 Sodium lauroyl methyl taurate: 0.2 Polyoxyethylene (5) hydrogenated castor oil: 1.5 Polishable silica*1:10 Thickening silica*2:5 Coconut oil fatty acid amidopropyl betaine: 1 70% sorbitol solution: 40 Sodium carboxymethylcellulose*3:1.4 Xanthan gum: 0.5 Citric acid: 0.25 Sodium citrate: 0.5 Titanium mica: 0.5 Yellow No. 5: 0.00025 Fragrance composition A: 1.3 Methylparaben: 0.15 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0103] Formulation Example 17 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Saccharin sodium: 0.2 Tocopherol acetate: 0.1 Tranexamic acid: 0.05 Potassium nitrate: 5 Isopropylmethylphenol: 0.05 Sodium pyrophosphate: 0.5 Sodium lauroyl methyl taurate: 1 Polyoxyethylene (5) hydrogenated castor oil: 1.5 Abrasive silica *1: 15 Viscosity - increasing silica *2: 8 Titanium oxide: 0.05 Coconut oil fatty acid amide propyl betaine: 2.5 85% Glycerin: 30 Propylene glycol: 3 Propylene glycol alginate: 0.1[[ID=​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Sodium saccharin: 0.1 Xylitol: 5 Mannitol: 0.1 Tocopherol acetate: 0.1 β-Glycyrrhetinic acid: 0.02 Tranexamic acid: 0.05 Sodium lauryl sulfate: 0.8 Sodium lauroyl sarcosinate: 0.1 Polyoxyethylene (20) hydrogenated castor oil: 1 Polyoxyethylene (5) stearyl ether: 1 Benzalkonium chloride: 0.01 Heavy calcium carbonate: 20 Thickening silica*1:4 Sodium carboxymethylcellulose*2:1 Sodium polyacrylate: 0.3 70% sorbitol solution: 55 Propylene glycol: 3 Polyethylene glycol 4000:0.5 Scutellaria baicalensis extract: 0.005 Carrot extract: 0.001 Phellodendron bark extract: 0.05 Rosemary extract: 0.001 Sage extract: 0.001 Tea extract: 0.001 Fragrance composition A:1 Water: Balance Total: 100 *1 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *2 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0105] Prescription example 19 Pyridoxine hydrochloride: 0.2 Sodium monofluorophosphate: 1.1 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.1 Tocopherol acetate: 0.1 Aluminum lactate: 2 Isopropyl methylphenol: 0.1 Tranexamic acid: 0.1 Potassium nitrate: 5 Sodium chloride: 1 Sodium lauroyl methyl taurate: 1 Polyoxyethylene (20) hydrogenated castor oil: 0.6 Polyoxyethylene (5) stearyl ether: 0.6 Abrasive silica *1: 10 Viscosity - increasing silica *2: 3 Titanium oxide: 1 Coconut oil fatty acid amide propyl betaine solution *3: 1 70% sorbitol solution: 32 Propylene glycol: 5 Polyethylene glycol 4000: 0.5 Xanthan gum: 0.3 Carrageenan: 0.9 Sodium alginate: 0.9 Sodium hydroxide: 0.1 Sodium dihydrogen phosphate: 1 Methyl paraben: 0.2 Fragrance composition A: 1.5 Water: balance Total: 100 *1 Abrasive silica: EVONIK Corporation Zeodent 124 *2 Viscosity - increasing silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption amount 2.3) ​​​​​​​​​​​​​​​​​ Tranexamic acid: 0.05 Copper gluconate: 0.1 Sodium lauryl sulfate: 1.5 Sodium lauroyl sarcosinate: 0.2 Sodium lauroyl methyl taurate: 1.2 Polyoxyethylene (20) hydrogenated castor oil: 1.5 Polyoxyethylene(5) stearyl ether: 1.5 Polishable silica*1:10 Thickening silica*2:6 Titanium dioxide: 0.1 Coconut oil fatty acid amidopropyl betaine solution *3:1 85% Glycerin: 45 Propylene glycol: 3 Polyethylene glycol 4000:0.4 Xanthan gum: 0.5 Sodium carboxymethylcellulose*4:1 Sodium hydroxide: 0.1 Methylparaben: 0.2 Fragrance composition A: 1.5 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated. *4 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0107] Prescription Example 21 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.1 Xylitol: 8 Sodium lauryl sulfate: 1.4 Abrasive silica*1:12 Thickening silica*2:2 Titanium dioxide: 0.4 Aluminum oxide: 0.5 70% sorbitol solution: 32 Propylene glycol: 3 Xanthan gum: 0.55 Sodium polyacrylate: 0.55 Methylparaben: 0.1 Fragrance composition A:1 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3)

[0108] Prescription Example 22 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.18 Sucralose: 0.1 Sodium lauroyl sarcosinate: 0.2 Sodium lauryl sulfate: 1.7 Polyoxyethylene (20) hydrogenated castor oil: 0.3 Abrasive silica*1:15 Thickening silica*2: 4.5 Aluminum oxide: 0.5 Xanthan gum: 0.5 Sodium polyacrylate: 1.5 70% sorbitol solution: 35 Propylene glycol: 4 Methylparaben: 0.18 Fragrance composition A: 1.4 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3)

[0109] Prescription Example 23 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.18 Xylitol: 0.8 Sodium lauroyl sarcosinate: 0.2 Sodium lauryl sulfate: 1.2 Polyoxyethylene (20) hydrogenated castor oil: 0.5 Abrasive silica*1:17 Thickening silica*2: 3.5 Titanium dioxide: 0.5 Coconut oil fatty acid amidopropyl betaine solution*3:0.8 Sodium alginate: 0.2 Xanthan gum: 1.6 Sodium polyacrylate: 0.3 70% sorbitol solution: 40 Propylene glycol: 4 Methylparaben: 0.18 Fragrance composition A: 1.3 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0110] Prescription Example 24 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.05 Tocopherol acetate: 1 Tranexamic acid: 0.05 Isopropylmethylphenol: 0.1 Dipotassium glycyrrhizinate: 0.15 Sodium lauroyl sarcosinate: 0.2 Sodium lauryl sulfate: 1.8 Polyoxyethylene (5) hydrogenated castor oil: 2.5 Thickening silica*1:5 70% sorbitol solution: 55 Propylene glycol: 5 Polyethylene glycol 4000:1 Sodium alginate: 0.6 Xanthan gum: 0.9 Sodium polyacrylate: 0.5 Anhydrous sodium sulfate: 0.5 Fragrance composition A:1 Water: Balance Total: 100 *1 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3)

[0111] Prescription example 25 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.16 Tocopherol acetate: 0.5 Tranexamic acid: 0.05 Isopropylmethylphenol: 0.07 Dipotassium glycyrrhizinate: 0.12 Sodium lauroyl sarcosinate: 0.2 Sodium lauroyl methyl taurate: 0.5 Sodium lauryl sulfate: 0.5 Polyoxyethylene (5) hydrogenated castor oil: 1.5 Polishable silica*1:10 Thickening silica*2:5 Titanium dioxide: 0.4 70% sorbitol solution: 50 Propylene glycol: 3 Polyethylene glycol 4000:2 Sodium alginate: 0.2 Xanthan gum: 1 Sodium polyacrylate: 0.5 Methylparaben: 0.2 Fragrance composition A:0.9 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3)

[0112] Prescription Example 26 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.03 Tocopherol acetate: 0.1 Isopropylmethylphenol: 0.1 Tranexamic acid: 0.05 Sodium lauroyl sarcosinate: 0.2 Sodium lauroyl methyl taurate: 0.4 Polyoxyethylene (20) hydrogenated castor oil: 2 Polyoxyethylene (5) stearyl ether: 2 Thickening silica*1: 1.5 Thickening silica*2: 1.5 Polishable silica*3:10 70% sorbitol solution: 45 Propylene glycol: 5 Polyethylene glycol 4000:3 Sodium alginate: 0.6 Xanthan gum: 1.2 Sodium polyacrylate: 0.3 Hydroxyethylcellulose dimethyldiallylammonium chloride: 0.05 Sodium pyrrolidonecarboxylate: 6 Citric acid: 0.2 Sodium citrate: 0.4 Fragrance composition A: 1.8 Water: Balance Total: 100 *1 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *2 Thickening silica: Nippon Aerosil Co., Ltd. Aerosil 200 (liquid absorption capacity 4.2) *3 Abrasive silica: EVONIK Co., Ltd. Zeodent 124

[0113] Prescription example 27 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.06 Tocopherol acetate: 0.15 Isopropylmethylphenol: 0.1 Tranexamic acid: 0.05 Dipotassium glycyrrhizinate: 0.035 Sodium chloride: 8 Potassium nitrate: 5 Sodium polyphosphate: 0.5 Allantoin: 0.1 Sodium lauroyl sarcosinate: 0.2 Sodium lauryl sulfate: 1.5 Polyoxyethylene (5) hydrogenated castor oil: 0.5 Polishable silica*1:10 Thickening silica*2:3 Titanium dioxide: 0.4 70% sorbitol solution: 30 Propylene glycol: 3 Polyethylene glycol 400:1 Xanthan gum: 2 Sodium polyacrylate: 0.5 Sodium citrate: 0.5 Methylparaben: 0.18 Sodium hydroxide (48% solution): 0.2 Fragrance composition A: 1.6 Water: Balance Total: 100 *1 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *2 Thickening silica: Nippon Aerosil Co., Ltd. Aerosil 200 (liquid absorption capacity 4.2)

[0114] Prescription example 28 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.08 Tocopherol acetate: 0.1 Isopropylmethylphenol: 0.1 Tranexamic acid: 0.05 Sodium lauroyl sarcosinate: 0.2 Sodium lauryl sulfate: 1.2 Polyoxyethylene (20) hydrogenated castor oil: 1.25 Polyoxyethylene(5) stearyl ether: 1.25 Thickening silica*1:3 Thickening silica*2:3 70% sorbitol solution: 55 Propylene glycol: 3 Polyethylene glycol 4000:1 Xanthan gum: 1.5 Sodium alginate: 0.3 Anhydrous sodium sulfate: 2 Isostearic acid: 0.2 Methylparaben: 0.2 Fragrance composition A:1.2 Water: Balance Total: 100 *1 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *2 Thickening silica: Nippon Aerosil Co., Ltd. Aerosil 200 (liquid absorption capacity 4.2)

[0115] Prescription example 29 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.18 Xylitol: 0.01 Sucralose: 0.01 Mannitol: 0.01 Tocopherol acetate: 0.1 Isopropylmethylphenol: 0.05 Allantoin: 0.1 Tranexamic acid: 0.05 Hinokitiol: 0.1 Polishable silica*1:10 Thickening silica*2:5 Titanium dioxide: 0.3 Sodium lauroyl methyl taurate: 0.6 Sodium lauryl sulfate: 0.2 Polyoxyethylene (20) hydrogenated castor oil: 1 Coconut oil fatty acid amidopropyl betaine*3:0.5 85% Glycerin: 50 Propylene glycol: 3 Polyethylene glycol 4000:0.3 Propylene glycol alginate: 0.1 Sodium alginate: 0.8 Xanthan gum: 1 Citric acid: 0.6 Sodium citrate: 0.6 Fragrance composition A: 1.3 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0116] Prescription example 30 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.16 Tocopherol acetate: 0.1 Isopropylmethylphenol: 0.05 Sodium polyphosphate: 1 Tranexamic acid: 0.05 Sodium lauroyl methyl taurate: 1.2 Polyoxyethylene (20) hydrogenated castor oil: 1.25 Polyoxyethylene(5) stearyl ether: 1.25 Polishable silica*1:10 Thickening silica*2:5 Titanium dioxide: 0.4 70% sorbitol solution: 48 Propylene glycol: 3 Polyethylene glycol 4000:0.1 Propylene glycol alginate: 0.5 Sodium carboxymethylcellulose*3:1.2 Sodium polyacrylate: 0.5 Phytosteryl isostearate: 0.1 Isostearic acid: 0.1 Fragrance composition A: 1.3 Methylparaben: 0.18 Anhydrous sodium sulfate: 1 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0117] Prescription example 31 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.18 Tocopherol acetate: 0.1 Potassium nitrate: 5 Tranexamic acid: 0.2 Allantoin: 0.2 Isopropylmethylphenol: 0.2 Sodium lauroyl methyl taurate: 1.5 Polyoxyethylene (20) hydrogenated castor oil: 0.25 Polyoxyethylene(5) stearyl ether: 0.25 Polishable silica*1:10 Thickening silica*2:6 Titanium dioxide: 0.5 Coconut oil fatty acid amidopropyl betaine*3:0.3 70% sorbitol solution: 45 Propylene glycol: 4 Polyethylene glycol 4000:0.5 Propylene glycol alginate: 0.1 Sodium alginate: 0.6 Xanthan gum: 1.2 Citric acid: 0.25 Sodium citrate: 0.5 Phytosteryl isostearate: 0.3 Isostearic acid: 0.3 Fragrance composition A: 1.3 Methylparaben: 0.18 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0118] Prescription Example 32 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Tocopherol acetate: 0.1 Tranexamic acid: 0.05 Potassium nitrate: 5 Isopropylmethylphenol: 0.05 Sodium polyphosphate: 1 Sodium azulene sulfonate: 0.01 Sodium lauroyl methyl taurate: 0.2 Polyoxyethylene (5) hydrogenated castor oil: 1.5 Polishable silica*1:10 Thickening silica*2:5 Coconut oil fatty acid amidopropyl betaine*3:0.6 70% sorbitol solution: 20 85% Glycerin: 20 Propylene glycol: 4 Polyethylene glycol 4000:0.4 Propylene glycol alginate: 0.1 Xanthan gum: 1.6 Sodium alginate: 0.6 Titanium mica: 0.7 Red No. 106: 0.000025 Yellow No. 4: 0.00025 Fragrance composition A:1 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0119] Prescription Example 33 Pyridoxine hydrochloride: 0.2 Sodium monofluorophosphate: 1.1 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.15 Xylitol: 2 Sucralose: 0.003 Tocopherol acetate: 0.1 Phellodendron bark extract: 0.05 Isopropylmethylphenol: 0.1 Tranexamic acid: 0.05 Sodium chloride: 5 Hinokitiol: 0.05 Sodium lauroyl sarcosinate: 0.2 Sodium lauryl sulfate: 1.5 Polyoxyethylene (5) hydrogenated castor oil: 2.5 Polishable silica*1:10 Thickening silica*2:1 Aluminum oxide: 0.1 Coconut oil fatty acid amidopropyl betaine*3:0.1 70% sorbitol solution: 45 Propylene glycol: 4 Polyethylene glycol 400:1 Polyethylene glycol 4000:0.4 Xanthan gum: 0.3 Carrageenan: 0.9 Sodium alginate: 0.9 Aluminum potassium sulfate: 1 Sodium hydroxide: 0.1 Fragrance composition A:0.7 Water: Balance Total: 100 *1 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *2 Thickening silica: Nippon Aerosil Co., Ltd. Aerosil 200 (liquid absorption capacity 4.2) *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0120] Prescription example 34 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Tocopherol acetate: 0.1 Dextranase*1:0.2 (Enzyme activity per gram of preparation: 20 U): Sodium tripolyphosphate: 2 Benzalkonium chloride: 0.01 Sodium lauryl sulfate: 0.3 N-lauroyl-L-glutamate sodium:1 Polyoxyethylene (20) hydrogenated castor oil: 1 Polyoxyethylene (5) stearyl ether: 1 Decaglycerin fatty acid ester: 0.1 Abrasive silica*2:20 Thickening silica*3:3 Titanium dioxide: 0.5 Coconut oil fatty acid amidopropyl betaine solution *4:2 70% sorbitol solution: 35 Propylene glycol: 3 Polyethylene glycol 4000:1 Xanthan gum: 0.5 Sodium polyacrylate: 0.5 Carrageenan: 0.3 DL-Alanine: 0.2 Fragrance composition A:1.2 Water: Balance Total: 100 *1 Dextranase: Mitsubishi Chemical Corporation Dextranase 2F (enzyme activity 4000 U / g) *2 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *3 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *4 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0121] Prescription example 35 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.15 Sucralose: 0.01 Sodium lauryl sulfate: 1.2 N-lauroyl-L-sodium glutamate: 0.3 Abrasive silica*1:18 Thickening silica*2:3 70% sorbitol solution: 35 Propylene glycol: 3 Sodium alginate: 1 Fragrance composition A: 1.3 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3)

[0122] Prescription Example 36 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.17 Sodium lauryl sulfate: 1 Polyoxyethylene (20) hydrogenated castor oil: 0.5 Heavy calcium carbonate: 20 Granular zeolite (average particle size 282 μm) *1:5 Thickening silica*2:5 Aluminum oxide: 1 70% sorbitol solution: 30 Propylene glycol: 2 Sodium carboxymethylcellulose*3:1.5 Methylparaben: 0.2 Fragrance composition A:1 Water: Balance Total: 100 *1 Granular zeolite: Zeolite; 80%, Anhydrous silicic acid; 18.89%, Titanium dioxide; 0.1%, Blue No. 201; 0.01% *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0123] Prescription example 37 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.1 Sodium lauryl sulfate: 1.5 Abrasive silica*1:25 Silica granules (average particle size 250 μm) * 2:3 Silica granules (average particle size 100 μm) * 3:2 70% sorbitol solution: 40 Propylene glycol: 3 Sodium carboxymethylcellulose*4:1.5 Fragrance composition A:1 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Silica granules: SORBOSIL BFG50 *3 Silica granules: SORBOSIL BFG10 *4 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0124] Prescription example 38 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Sucralose: 0.001 Tocopherol acetate: 0.2 Dipotassium glycyrrhizinate: 0.1 Isopropylmethylphenol: 0.05 Cetylpyridinium chloride: 0.05 Alkyl glucoside:1 Polyoxyethylene (10) cetyl ether: 1 Abrasive silica*1:15 Thickening silica*2:3 70% sorbitol solution: 40 Propylene glycol: 0.5 Sodium carboxymethylcellulose*3:1 Sodium polyacrylate: 0.2 Propylene glycol alginate: 0.1 Sodium pyrrolidonecarboxylate: 3 Fragrance composition A:1.2 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3) *3 Carboxymethylcellulose sodium: Daicel Mirise Co., Ltd. CMC1260

[0125] Prescription example 39 Pyridoxine hydrochloride: 0.2 Stannous fluoride: 0.6 (Fluoride ion concentration: 1450 ppm) Sodium saccharin: 0.2 Tocopherol acetate: 0.5 Tranexamic acid: 0.05 Isopropylmethylphenol: 0.05 Sodium lauroyl methyl taurate: 1 Sodium tetradecenesulfonate: 0.5 Polyoxyethylene (5) hydrogenated castor oil: 2 Polishable silica*1:10 Thickening silica*2:3 Titanium dioxide: 0.05 70% sorbitol solution: 40 Propylene glycol: 3 Polyethylene glycol 4000:0.2 Xanthan gum: 1.2 Sodium alginate: 0.4 Propylene glycol alginate: 0.1 Titanium mica: 0.3 Citric acid: 0.8 Sodium citrate: 0.5 Fragrance composition A:1 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3)

[0126] Prescription example 40 Pyridoxine hydrochloride: 0.2 Stannous fluoride: 0.4 (Fluoride ion concentration: 970 ppm) Sodium fluoride: 0.11 (Fluoride ion concentration: 500 ppm) Sodium saccharin: 0.2 Tocopherol acetate: 0.5 Tranexamic acid: 0.05 Isopropylmethylphenol: 0.05 Sodium lauroyl methyl taurate: 1 Sodium tetradecenesulfonate: 0.5 Polyoxyethylene (5) hydrogenated castor oil: 2 Polishable silica*1:10 Thickening silica*2:3 Titanium dioxide: 0.05 Zinc oxide: 0.3 70% sorbitol solution: 40 Propylene glycol: 3 Polyethylene glycol 4000:0.2 Xanthan gum: 1.2 Sodium alginate: 0.4 Propylene glycol alginate: 0.1 Titanium mica: 0.3 Citric acid: 0.8 Sodium citrate: 0.5 Fragrance composition A:1 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3)

[0127] Prescription example 41 Pyridoxine hydrochloride: 0.2 Stannous fluoride: 0.4 (Fluoride ion concentration: 970 ppm) Sodium monofluorophosphate: 0.38 (Fluoride ion concentration: 500 ppm) Sodium saccharin: 0.2 Tocopherol acetate: 0.5 Tranexamic acid: 0.05 Isopropylmethylphenol: 0.05 Sodium lauroyl methyl taurate: 1 Sodium tetradecenesulfonate: 0.5 Polyoxyethylene (5) hydrogenated castor oil: 2 Polishable silica*1:10 Thickening silica*2:3 Titanium dioxide: 0.05 Zirconium oxide: 0.5 70% sorbitol solution: 40 Propylene glycol: 3 Polyethylene glycol 4000:0.2 Xanthan gum: 1.2 Sodium alginate: 0.4 Propylene glycol alginate: 0.1 Titanium mica: 0.3 Citric acid: 0.8 Sodium citrate: 0.5 Fragrance composition A:1 Water: Balance Total: 100 *1 Abrasive silica: EVONIK Co., Ltd. Zeodent 124 *2 Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (liquid absorption capacity 2.3)

[0128] Prescription example 42 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Tocopherol acetate: 2 Glycyrrhetinic acid: 0.3 Cetylpyridinium chloride: 0.05 Sodium lauryl sulfate: 1.6 Sorbitan monostearate: 1 POE(20) Sorbitan Monostearate: 1.5 Sucrose fatty acid ester: 2 Thickening silica*1:3 Hydroxyethylcellulose*2:1.5 Hydroxypropyl methylcellulose*3:1 Carboxyvinyl polymer: 2.1 Polyvinylpyrrolidone: 1 70% sorbitol solution: 20 Propylene glycol: 5 Ethanol: 1 Light liquid paraffin: 2 Cetanol: 1.4 Fragrance composition A: 1.5 Water: Balance Total: 100 *1 Thickening silica: Nippon Aerosil Co., Ltd. Aerosil 200 (liquid absorption capacity 4.2) *2 Hydroxyethylcellulose: Daicel Mirise Co., Ltd. HEC Daicel EE-820 *3 Hydroxypropyl methylcellulose: Shin-Etsu Chemical Co., Ltd. METOLOSE Hypromellose 90SH-4000SR

[0129] Prescription example 43 Pyridoxine hydrochloride: 0.2 Sodium fluoride: 0.32 (Fluoride ion concentration: 1450 ppm) Tocopherol acetate: 1.5 Dipotassium glycyrrhizinate: 0.4 Cetylpyridinium chloride: 0.05 Hinokitiol: 0.1 Allantoin: 0.3 Sodium lauryl sulfate: 1.1 Sorbitan monostearate: 0.1 POE(20) Sorbitan Monostearate: 0.15 Sucrose fatty acid ester: 0.5 Thickening silica*1:3 Hydroxypropylmethylcellulose*2:0.3 Carboxyvinyl polymer*3:2.1 Polyvinylpyrrolidone* 4:1 Sodium alginate*5:0.3 70% sorbitol solution: 25 Propylene glycol: 7 Ethanol: 3 Light liquid paraffin: 0.5 Fragrance composition A:1 Water: Balance Total: 100 *1 Thickening silica: Aerosil 200 (absorption capacity 4.2L) manufactured by Nippon Aerosil Co., Ltd. *2 Hydroxypropyl methylcellulose: Shin-Etsu Chemical Co., Ltd. METOLOSE Hypromellose 90SH-4000SR *3 Carboxyvinyl polymer: Lublizol Carbopol 980NF *4 Polyvinylpyrrolidone: ISP PLASDONE K-90 *5 Sodium alginate: Kimika Co., Ltd. Kimika Algin ULV-20

[0130] [Table 6]

[0131] [Table 7]

[0132] [Table 8]

[0133] Table 9

[0134] Table 10

Claims

1. (A) Components: Pyridoxine or its salt, and (B) Component: Contains a fluorine-containing compound, (A) The content of component is 0.11 to 0.95% by mass, (B) The amount of component contained is such that, when converted to a fluoride ion concentration, it is between 1,000 and 20,000 ppm. Oral composition.

2. Furthermore, the oral composition according to claim 1, further comprising (C) component: at least one sweetener selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol.

3. The oral composition according to claim 2, wherein the content of component (C) is 0.01 to 10% by mass.

4. Furthermore, the oral composition according to claim 1 or 2, further comprising (D) component: at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate.

5. The oral composition according to claim 4, wherein the content of component (D) is 0.03 to 2% by mass.

6. The oral composition according to claim 1 or 2, wherein the ratio of the content (mass%) of component (A) to the content (ppm) of component (B) as a fluoride ion concentration, multiplied by 1000, is 0.005 to 0.42.

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