Toothpaste composition

Abstract

To provide a toothpaste composition that can suppress discoloration over time. [Solution] A toothpaste composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: one or more nonionic surfactants selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, alkyl glycoside, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, sugar alcohol fatty acid ester, alkylolamide, fatty acid ethanolamide, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block copolymer, and polyoxyethylene polyoxypropylene fatty acid ester, wherein the content of component (A) is 0.01% by mass or more and less than 0.2% by mass.

Description

Technical Field

[0001] The present invention relates to a dentifrice composition.

Background Art

[0002] Conventionally, from the viewpoint of imparting effects such as a periodontal disease preventive effect, more specifically, a short-chain fatty acid reduction effect, a glycation reaction inhibitory effect, a metabolism promoting effect, and an anti-inflammatory effect, a mode of blending pyridoxine (vitamin B6) or a salt thereof in an oral composition containing a dentifrice has been known.

[0003] Specifically, for example, in Patent Document 1 below, for the purpose of improving the retention and absorption of pyridoxine hydrochloride, which is a water-soluble active ingredient, in oral tissues, one or more selected from fatty acids having a branched-chain structure, fatty acid esters having a linear or branched-chain structure, and polyglycerol fatty acid esters are blended, and in Patent Document 2 below, in an oral composition, for the purpose of stably containing pyridoxine or a salt thereof, a mode of containing tocopherol nicotinate and / or tocopherol acetate in the oral composition together with pyridoxine or a salt thereof is described, and in Patent Document 3 below, for the purpose of leaving vitamins such as pyridoxine hydrochloride that can sufficiently exert an effect on tooth surfaces and tooth gums, achieving sufficient plaque control and an increase in blood flow to the tooth gums, and maintaining and improving the oral hygiene environment, in a liquid oral composition, a predetermined amount of vitamins and a non-anionic water-soluble polymer are blended and adjusted to have a predetermined viscosity.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Patent Document 3

[0005] Adding pyridoxine or its salts as an ingredient to toothpaste compositions can impart desirable properties such as an astringent sensation to the oral mucosa. However, depending on the amount of pyridoxine or its salts added, the toothpaste composition may discolor over time due to storage or other factors.

[0006] Therefore, the object of the present invention is to provide a toothpaste composition that can effectively suppress discoloration over time. [Means for solving the problem]

[0007] The inventors diligently conducted research to suppress discoloration over time in toothpaste compositions containing a predetermined amount of pyridoxine or its salt, and found that the above problem could be solved by incorporating a predetermined amount of nonionic surfactant, thus completing the present invention. In other words, the present invention provides the following [1] to [7]. [1] (A) Components: Pyridoxine or a salt thereof, (B) Components: One or more nonionic surfactants selected from the group consisting of polyoxyethylene hydrogenated castor oil having an average number of ethylene oxide added moles of less than 60, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, alkyl glycoside, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, sugar alcohol fatty acid ester, alkylolamide, fatty acid ethanolamide, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block copolymer, and polyoxyethylene polyoxypropylene fatty acid ester, (A) A toothpaste composition having an ingredient content of 0.01% by mass or more and less than 0.2% by mass. [2] The toothpaste composition according to [1], wherein the content of component (B) is 0.01% to 5% by mass. [3] (C) component: toothpaste composition according to [1] or [2], further comprising an amphoteric surfactant. [4] (D) component: toothpaste composition according to any one of [1] to [3], further comprising inorganic powder. [5] (E) Components: A toothpaste composition according to any one of [1] to [4], further comprising one or more selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol. [6] (F) component: toothpaste composition according to any one of [1] to [5], further comprising one or more selected from the group consisting of tocopherol acetate and tocopherol nicotinate. [7] The toothpaste composition according to any one of [1] to [6], wherein the ratio of the content of component (A) to the content of component (B) ((A) / (B)) is 0.002 to 1.5. [Effects of the Invention]

[0008] According to the present invention, a toothpaste composition containing a predetermined amount of pyridoxine can be provided that can suppress discoloration over time caused by the inclusion of pyridoxine or a salt thereof. [Modes for carrying out the invention]

[0009] The toothpaste composition of the present invention will be described in detail below. The toothpaste composition of the present invention comprises (A) component: pyridoxine or a salt thereof, and (B) component: one or more nonionic surfactants selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, alkyl glycoside, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, sugar alcohol fatty acid ester, alkylolamide, fatty acid ethanolamide, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block copolymer, and polyoxyethylene polyoxypropylene fatty acid ester, wherein the content of component (A) is 0.01% by mass or more and less than 0.2% by mass.

[0010] First, we will describe the components (A) and (B) contained in the toothpaste composition of this embodiment, as well as the components (C), (D), (E), and (F) that may be included in the toothpaste composition of this embodiment, and any other optional components that may be included.

[0011] [(A) Ingredients: Pyridoxine or its salt] (A) Pyridoxine or its salt, which is an ingredient, is an ingredient that can provide a periodontal disease prevention effect. In the toothpaste composition of this embodiment, pyridoxine or its salt is an ingredient that can also provide an astringent sensation, especially on the oral mucosa, when used.

[0012] In this embodiment, the pyridoxine salt is not particularly limited as long as it is a pharmaceutically acceptable salt that exhibits the effects described above. Examples of pyridoxine salts include pyridoxine hydrochloride, pyridoxine sulfate, pyridoxine nitrate, pyridoxine hydrobromide, and pyridoxine phosphate. Among the pyridoxine salts, pyridoxine hydrochloride is preferred.

[0013] Here, pyridoxine hydrochloride (pyridoxine hydrochloride) is a salt of pyridoxine and is a type of vitamin B6. (A) component may be used alone, or two or more thereof may be used in combination.

[0014] In the dentifrice composition of the present embodiment, the content of component (A) is 0.01% by mass or more, preferably 0.015% by mass or more, more preferably 0.02% by mass or more from the viewpoint of imparting good periodontal disease prevention effect and astringency when the total amount of the dentifrice composition is 100% by mass. Also, the content of component (A) is less than 0.2% by mass, preferably 0.19% by mass or less, or 0.15% by mass or less, more preferably 0.12% by mass or less, or 0.1% by mass or less from the viewpoint of improving discoloration over time of the dentifrice composition. Therefore, the content of component (A) is 0.01% by mass or more and less than 0.2% by mass, preferably 0.01% to 0.19% by mass, or 0.01% to 0.15% by mass, more preferably 0.015% to 0.12% by mass, or 0.02% to 0.1% by mass.

[0015] [(B) component: nonionic surfactant] The nonionic surfactant as component (B) is a component that can effectively suppress discoloration over time due to storage, etc. of the dentifrice composition accompanying the blending of component (A) already described.

[0016] In the present embodiment, as component (B), one or more selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerol fatty acid ester, alkyl glycoside, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, sugar alcohol fatty acid ester, alkylolamide, fatty acid ethanolamide, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block copolymer and polyoxyethylene polyoxypropylene fatty acid ester can be used.

[0017] Examples of component (B) that can be used in this embodiment include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, polyglycerin fatty acid esters, alkyl glucosides, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate and polyoxyethylene sorbitan monooleate, sucrose fatty acid esters such as sucrose stearate and sucrose palmitate, sugar alcohol fatty acid esters such as maltitol fatty acid ester and lactitol fatty acid ester, fatty acid ethanolamides such as alkylolamide and lauric acid mono or diethanolamide, sorbitan fatty acid esters, polyoxyethylene polyoxypropylene block copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. In this embodiment, component (B) may be one of the above-mentioned nonionic surfactants used alone, or two or more may be used in combination, or a commercially available product may be used.

[0018] The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is less than 60, preferably 5 or more and less than 60, more preferably 5 or more and 20 or less (hereinafter, the average number of moles of ethylene oxide added may be indicated in parentheses). The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ether is preferably 10 to 26, more preferably 14 to 24, still more preferably 14 to 22, and the average number of moles of ethylene oxide added is preferably 2 to 50, more preferably 5 to 50, still more preferably 5 to 30. The number of carbon atoms in the fatty acid of polyglycerol fatty acid ester is preferably 10 to 20, and the average degree of polymerization of glycerin is preferably 1 to 20. The number of carbon atoms in the alkyl chain of alkyl glycoside is preferably 8 to 20. The number of carbon atoms in the fatty acid of sorbitan fatty acid ester is preferably 10 to 18. The number of carbon atoms in the fatty acid of polyoxyethylene sorbitan fatty acid ester is preferably 12 to 18, and the average number of moles of ethylene oxide added is preferably 20 to 80. The number of carbon atoms in the fatty acid of sucrose fatty acid ester is preferably 8 to 20. The number of carbon atoms in the alkyl chain of alkylolamide is preferably 12 to 14. The number of carbon atoms in the fatty acid of fatty acid ethanolamide is preferably 10 to 16. The average number of moles of ethylene oxide added to polyoxyethylene polyoxypropylene block copolymer is preferably 4 to 70, and the average number of moles of propylene oxide added is preferably 4 to 70. The number of carbon atoms in the fatty acid of polyoxyethylene polyoxypropylene fatty acid ester is preferably 10 to 18, the average number of moles of ethylene oxide added is preferably 4 to 70, and the average number of moles of propylene oxide added is preferably 4 to 70.

[0019] In this embodiment, component (B) is preferably polyoxyethylene hydrogenated castor oil, polyoxyethylene stearyl ether, polyglycerin fatty acid ester, sucrose stearate ester, and polyoxyethylene sorbitan monostearate, from the viewpoint of effectively suppressing discoloration of the toothpaste composition over time; more preferably polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (5) hydrogenated castor oil, polyoxyethylene (5) stearyl ether, decaglyceryl laurate, sucrose stearate ester, and polyoxyethylene (20) sorbitan monostearate; and even more preferably polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (5) hydrogenated castor oil, polyoxyethylene (5) stearyl ether, and decaglyceryl laurate. In this embodiment, component (B) may be one of the above-mentioned types alone, or two or more types in combination, or a commercially available product may be used.

[0020] In the toothpaste composition of this embodiment, the total content of component (B) is not particularly limited. The total content of component (B) is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and even more preferably 0.5% by mass or more, when the total amount of the toothpaste composition is 100% by mass, from the viewpoint of effectively suppressing discoloration of the toothpaste composition over time. From the viewpoint of effectively imparting an astringent sensation with component (A), suppressing the taste of component (B) and the irritation during use caused by its combination with component (A), and making it easier to exhibit the improvement of irritation with component (C) and / or component (D) described later, and further the improvement of unpleasant taste during use with component (E) and / or (F), it is preferably 5% by mass or less, more preferably 4% by mass or less, and even more preferably 3% by mass or less. Therefore, the content of the nonionic surfactant is preferably 0.01% to 5% by mass, more preferably 0.1% to 4% by mass, and even more preferably 0.5% to 3% by mass, from the viewpoint of providing a good astringent sensation, effectively suppressing discoloration over time, suppressing the taste caused by component (B) and the irritation during use caused by the combination with component (A), improving the irritation caused by component (C) and / or component (D) described later, and further making it easier to exhibit the effect of improving the unpleasant taste during use caused by component (E) and / or (F).

[0021] [(C) Ingredients: Amphoteric surfactant] The amphoteric surfactant, which is component (C), is an ingredient that can effectively suppress the irritation that may occur when components (A) and (B) are combined, as described above.

[0022] In this embodiment, component (C) may include, for example, betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine), fatty acid amidopropyldimethylaminoacetic acid betaine (e.g., coconut oil fatty acid amidopropyl betaine, cocamidopropyl betaine), and alkyl betaine (e.g., lauryl betaine, stearyl betaine); and imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt (e.g., N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), coconut oil fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

[0023] In this embodiment, as component (C), it is preferable to use a betaine-type amphoteric surfactant and an imidazoline-type amphoteric surfactant from the viewpoint of effectively suppressing the irritation that may occur with the blending of components (A) and (B). The betaine-type amphoteric surfactant is preferably fatty acid amidopropyl dimethylaminoacetic acid betaine, and more preferably coconut oil fatty acid amidopropyl betaine. The imidazoline-type amphoteric surfactant is preferably alkylimidazolinium betaine, and more preferably 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine. Of these, as component (C), it is more preferable to use coconut oil fatty acid amidopropyl betaine and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, and even more preferably coconut oil fatty acid amidopropyl betaine. (C) The above amphoteric surfactant may be used alone, in combination of two or more, or a commercially available product may be used.

[0024] In the toothpaste composition of this embodiment, the content of the amphoteric surfactant, which is component (C), is not particularly limited. From the viewpoint of effectively suppressing the irritation that may occur when components (A) and (B) are used in combination, the content of the amphoteric surfactant, which is component (C), is preferably 0.005% by mass or more, 0.008% by mass or more, or 0.01% by mass or more, more preferably 0.02% by mass or more, or 0.05% by mass or more, and even more preferably 0.1% by mass or more, or 0.5% by mass or more, when the total amount of the toothpaste composition is 100% by mass. Furthermore, the content of component (C) is preferably 7% by mass or less, 6% by mass or less, or 5% by mass or less, more preferably 4% by mass or less, 3% by mass or less, or 2% by mass or less. Therefore, the content of component (C) is preferably 0.005% to 7% by mass, 0.008% to 6% by mass, or 0.01% to 5% by mass, and more preferably 0.02% to 4% by mass, 0.05% to 4% by mass, 0.1% to 3% by mass, or 0.5% to 2% by mass, from the viewpoint of effectively suppressing irritation and the occurrence of unpleasant tastes that may occur during brushing.

[0025] [(D) Component: Inorganic powder] The inorganic powder component (D) is an ingredient that can effectively suppress the irritation that may occur as a result of the blending of components (A) and (B) as described above.

[0026] Examples of inorganic powders that make up component (D) include inorganic calcium salts (e.g., calcium phosphate such as dicalcium phosphate dihydrate or anhydrous, monocalcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, tricalcium phosphate, tetracalcium phosphate, and octacalcium phosphate, calcium carbonate (light and heavy), calcium hydroxide, calcium sulfate, and calcium oxide); silica-based powders (anhydrous silicic acid (e.g., thickening anhydrous silicic acid (thickening silica), abrasive anhydrous silicic acid (abrasive silica)), zeolites, etc.); inorganic aluminum salts such as aluminum hydroxide and alumina; inorganic magnesium salts such as magnesium carbonate and trimagnesium phosphate; apatite-based powders such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; bentonite; titanium dioxide (titanium oxide); aluminum oxide; zinc oxide; and sodium hydrogen phosphate. (D) The inorganic powder may be used alone, in combination of two or more types, or a commercially available product may be used.

[0027] In this embodiment, component (D) is preferably a silica-based powder or an inorganic metal salt, and it is more preferable to use one or more selected from the group consisting of thickening anhydrous silicic acid (thickening silica), abrasive anhydrous silicic acid (abrasive silica), heavy calcium carbonate, anhydrous calcium hydrogen phosphate, titanium dioxide, aluminum oxide, and zinc oxide, and it is even more preferable to use one or more selected from the group consisting of thickening anhydrous silicic acid and abrasive anhydrous silicic acid.

[0028] Examples of abrasive anhydrous silica include precipitated silica, crystalline silica, igneous silica, amorphous silica, silica gel, aluminosilicate, zirconosilicate, and titanium-bonded silica. Among these, compounds mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, as well as calcium carbonate, are particularly preferred. Examples of precipitated silica include those with a particle size of 1 μm to 40 μm and a BET specific surface area of ​​10 to 250 square meters per gram. Here, the average particle size is the volume-based median diameter (D50) measured by laser diffraction / scattering. These abrasive anhydrous silicas may be used individually or in combination of two or more, or commercially available products may be used.

[0029] Examples of thickening anhydrous silicic acid include silica obtained by known manufacturing methods, such as precipitated silica and igneous silica, which have a liquid absorption capacity of 2 mL / g to 5 mL / g. The thickening anhydrous silicic acid has a specific surface area of ​​170 m². 2 / g~230m 2 Preferably, the thickening silica is at a concentration of / g and / or has a bulk density of 130 g / L to 160 g / L. As the thickening anhydrous silicic acid, one or more of these thickening anhydrous silicic acids may be used, or commercially available products may be used.

[0030] In the toothpaste composition of this embodiment, the content of component (D) is not particularly limited. From the viewpoint of effectively suppressing the irritation that may occur with the blending of components (A) and (B), the content of the inorganic powder which is component (D) is preferably 0.005% by mass or more, 0.008% by mass or more, or 0.01% by mass or more, more preferably 0.1% by mass or more, 1% by mass or more, 3% by mass or more, 5% by mass or more, or 10% by mass or more, when the total amount of the toothpaste composition is 100% by mass. Furthermore, the content of component (D) is preferably 60% by mass or less, 55% by mass or less, or 50% by mass or less, more preferably 45% by mass or less, 40% by mass or less, 30% by mass or less, or 25% by mass or less. Therefore, the content of component (D) is preferably 0.005% to 60% by mass, 0.008% to 55% by mass, or 0.01% to 50% by mass, and more preferably 0.1% to 45% by mass, 1% to 40% by mass, 3% to 30% by mass, 5% to 30% by mass, or 10% to 25% by mass.

[0031] In the toothpaste composition of this embodiment, component (D) is more preferably used in combination with component (C) from the viewpoint of more effectively suppressing the irritation that may occur as a result of the combination of components (A) and (B).

[0032] [(E) Ingredients: Sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol] Component (E) is an ingredient that can effectively suppress the unpleasant taste that may arise from the combination of components (A) and (B) as described above, the combination of components (A), (B), and (C), the combination of components (A), (B), and (D), and the combination of components (A), (B), (C), and (D).

[0033] In this embodiment, from the viewpoint of effectively suppressing any unpleasant taste that may arise from the blending of the above combinations of components (A), (B), (C), and (D), component (E) is preferably one or more selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol, and it is more preferable to use sodium saccharin and / or xylitol. Component (E) may be used alone, in combination of two or more, or a commercially available product may be used.

[0034] In the toothpaste composition of this embodiment, the content of component (E) is not particularly limited. From the viewpoint of effectively suppressing unpleasant taste, the content of component (E) is preferably 0.005% by mass or more, or 0.01% by mass or more, more preferably 0.015% by mass or more, 0.02% by mass or more, and even more preferably 0.05% by mass or more, when the total amount of the toothpaste composition is 100% by mass. Furthermore, the content of component (E) is preferably 13% by mass or less, or 10% by mass or less, more preferably 7% by mass or less, 5% by mass or less, and even more preferably 2% by mass or less, 1% by mass or less, or 0.5% by mass or less. Therefore, the content of component (E) is preferably 0.005% to 13% by mass, or 0.01% to 10% by mass, and more preferably 0.015% to 7% by mass, 0.02% to 5% by mass, 0.02% to 2% by mass, 0.05% to 1% by mass, or 0.05% to 0.5% by mass.

[0035] [(F) Ingredient: Tocopherol acetate and / or tocopherol nicotinate] The components (F), tocopherol acetate and tocopherol nicotinate, are components that can effectively suppress the unpleasant taste that may arise from the combination of components (A) and (B), components (A), (B), and (C), components (A), (B), and (D), and the combination of components (A), (B), (C), and (D) as described above.

[0036] In this embodiment, examples of tocopherol acetate and tocopherol nicotinate esters as component (F) include d-α-tocopherol acetate, dl-α-tocopherol acetate, d-α-tocopherol nicotinate, and dl-α-tocopherol nicotinate. Component (F) may be used alone, in combination of two or more, or a commercially available product may be used.

[0037] In this embodiment, component (F) is preferably one or more of the following, from the viewpoint of effectively suppressing any unpleasant taste that may arise from the blending of the above combinations of components (A), (B), (C), and (D). Component (F) is preferably d-α-tocopherol acetate, dl-α-tocopherol acetate, d-α-tocopherol nicotinate, or dl-α-tocopherol nicotinate, more preferably d-α-tocopherol acetate, dl-α-tocopherol acetate, or dl-α-tocopherol nicotinate, and even more preferably dl-α-tocopherol acetate.

[0038] In the toothpaste composition of this embodiment, the content of component (F) is not particularly limited. From the viewpoint of effectively suppressing unpleasant taste, the content of component (F) is preferably 0.01% by mass or more, 0.02% by mass or more, or 0.03% by mass or more, more preferably 0.04% by mass or more, or 0.05% by mass or more, when the total amount of the toothpaste composition is 100% by mass. Furthermore, the content of component (F) is preferably 4% by mass or less, 3% by mass or less, or 2% by mass or less, more preferably 1.5% by mass or less, or 1% by mass or less. Therefore, the content of component (F) is preferably 0.01% by mass to 4% by mass, 0.02% by mass to 3% by mass, or 0.03% by mass to 2% by mass, more preferably 0.03% by mass to 1.5% by mass, 0.04% by mass to 1.5% by mass, or 0.05% by mass to 1% by mass.

[0039] In the toothpaste composition of this embodiment, component (F) is more preferably used in combination with component (E) from the viewpoint of more effectively suppressing the unpleasant taste that may arise from the above-mentioned combination of components (A), (B), (C), and (D).

[0040] [Content ratio] -(A) / (B)(mass ratio)- The ratio of the content of component (A) to the content of component (B) ((A) / (B)) is preferably 0.001 or more, or 0.002 or more, more preferably 0.004 or more, or 0.006 or more. The ratio ((A) / (B)) is preferably 25 or less, or 17 or less, or 15 or less, even more preferably 10 or less, 7 or less, 5 or less, 3 or less, 1.5 or less, or 1 or less, and particularly preferably 0.8 or less, 0.5 or less, or 0.2 or less. Therefore, the ratio ((A) / (B)) is preferably 0.001 to 25, 0.002 to 17, or 0.002 to 15, more preferably 0.004 to 10, 0.004 to 7, 0.006 to 5, 0.006 to 3, or 0.006 to 1, and even more preferably 0.006 to 0.8, 0.006 to 0.5, or 0.006 to 0.2. By setting the ratio ((A) / (B)) in this way, it is possible to ensure an astringent sensation on the oral mucosa during toothbrushing and to effectively suppress discoloration over time.

[0041] -((A)+0.1×(B)) / (C)(mass ratio)- The ratio of the content of component (C) to the content of component (C), which is the sum of the content of component (A) obtained by multiplying the content of component (B) by 0.1, "((A) + 0.1 × (B)) / (C)", is preferably 0.002 or more, 0.004 or more, 0.005 or more, or 0.008 or more, more preferably 0.01 or more, or 0.03 or more. Furthermore, the ratio ((A) + 0.1 × (B)) / (C) is preferably 70 or less, 50 or less, 20 or less, or 10 or less, even more preferably 8 or less, 7 or less, or 6 or less, particularly preferably 4 or less, or 2 or less. Therefore, the ratio ((A) + 0.1 × (B)) / (C) is preferably 0.002 to 70, 0.002 to 50, 0.002 to 10, 0.004 to 70, 0.005 to 20, or 0.008 to 10, more preferably 0.01 to 8, or 0.03 to 8, even more preferably 0.03 to 7, or 0.03 to 6, and particularly preferably 0.03 to 4, or 0.03 to 2. By setting the ratio ((A) + 0.1 × (B)) / (C) in this way, the sensation of irritation can be suppressed more effectively.

[0042] -((A)+0.1×(B)) / (D)(mass ratio)- The ratio of the content of component (A) to the content of component (D), "((A) + 0.1 × (B)) / (D)", which is the sum of the content of component (A) obtained by multiplying the content of component (B) by 0.1, is preferably 0.0002 or more, 0.0004 or more, or 0.0005 or more, more preferably 0.0008 or more, or 0.001 or more, and even more preferably 0.005 or more. Furthermore, the ratio ((A) + 0.1 × (B)) / (D) is preferably 70 or less, 50 or less, or 40 or less, more preferably 20 or less, 10 or less, 5 or less, 1 or less, 0.5 or less, 0.25 or less, or 0.1 or less. Therefore, the ratio ((A) + 0.1 × (B)) / (D) is preferably 0.0002 to 70, 0.0002 to 50, 0.0004 to 70, or 0.0005 to 40, more preferably 0.0008 to 20, 0.0008 to 10, 0.001 to 5, 0.001 to 1, 0.001 to 0.5, 0.001 to 0.25, or 0.001 to 0.1, and even more preferably 0.005 to 0.1. By setting the ratio ((A) + 0.1 × (B)) / (D) in this way, the sensation of irritation can be suppressed more effectively.

[0043] -((A)+0.1×(B)) / (E)(mass ratio)- The ratio of the content of component (E) to the content of component (E), which is the sum of the content of component (A) obtained by multiplying the content of component (B) by 0.1, "((A) + 0.1 × (B)) / (E)", is preferably 0.001 or more, more preferably 0.002 or more, even more preferably 0.004 or more, 0.005 or more, or 0.006 or more, even more preferably 0.008 or more, 0.01 or more, or 0.05 or more, and particularly preferably 0.1 or more, or 0.5 or more. Furthermore, the ratio ((A) + 0.1 × (B)) / (E) is preferably 70,000 or less, 50,000 or less, 10,000 or less, 5,000 or less, 2,000 or less, 1,000 or less, or 500 or less, more preferably 300 or less, 200 or less, 100 or less, or 70 or less, and even more preferably 50 or less, 30 or less, or 15 or less. Therefore, the ratio ((A) + 0.1 × (B)) / (E) is preferably 0.001 to 70000, 0.002 to 50000, 0.002 to 10000, 0.002 to 5000, 0.002 to 2000, 0.002 to 1000, or 0.002 to 500, more preferably 0.002 to 300, 0.002 to 200, 0.002 to 100, or 0.002 to 70, even more preferably 0.004 to 50, 0.005 to 30, or 0.006 to 30, even more preferably 0.008 to 15, 0.01 to 15, or 0.05 to 15, and particularly preferably 0.1 to 15 or 0.5 to 15. By using the ratio ((A) + 0.1 × (B)) / (E) in this way, unpleasant sensations during brushing can be suppressed more effectively.

[0044] -((A)+0.1×(B)) / (F)(mass ratio)- The ratio of the content of component (A) to the content of component (F), which is the sum of the content of component (B) multiplied by 0.1 and the content of component (A), "((A) + 0.1 × (B)) / (F))", is preferably 0.01 or more, more preferably 0.02 or more, even more preferably 0.03 or more, and still more preferably 0.1 or more. Also, ((A) + 0.1 × (B)) / (F)) is preferably 24 or less, more preferably 10 or less, and still more preferably 8.0 or less. Therefore, the ratio ((A) + 0.1 × (B)) / (F)) is preferably 0.01 to 24, more preferably 0.02 to 10, even more preferably 0.03 to 8.0, and still still preferably 0.1 to 8. By setting the ratio ((A) + 0.1 × (B)) / (F) in this way, unpleasant odors during brushing can be suppressed more effectively.

[0045] [Optional ingredients] The toothpaste composition of this embodiment may contain optional components other than those already described, provided that the effects and benefits of the present invention are not impaired. These will be described in detail below.

[0046] Optional components in this embodiment include, for example, solvents, surfactants, sweeteners, fragrances, medicinal ingredients, oily components, preservatives, wetting agents, abrasives, binders, pH adjusters, and colorants (pigments). These can be formulated individually or in appropriate combinations of two or more. A detailed explanation follows below.

[0047] In this specification, the content of each component is based on the amount of each component added when manufacturing the toothpaste composition.

[0048] -solvent- The toothpaste composition of this embodiment may further contain a solvent. Preferably, water (purified water) or ethanol can be used as the solvent. The solvent may be one of the above solvents alone, or two or more solvents in combination, or a commercially available product may be used.

[0049] - Surfactants - The toothpaste composition of this embodiment may further contain surfactants other than components (B) and (C). Examples of surfactants that can be used in the toothpaste composition of this embodiment include anionic surfactants and cationic surfactants.

[0050] Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, lauryl sulfoacetate, and polyoxyethylene alkyl sulfosuccinate. The alkyl and acyl groups may be linear or branched, saturated or unsaturated, and the number of carbon atoms is preferably 10 to 20, more preferably 12 to 18, and even more preferably 12 to 14. The average number of ethylene oxide added to the polyoxyethylene alkyl sulfosuccinate is preferably 1 to 9. The salt can be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples of pharmacologically acceptable salts include inorganic base salts such as sodium salt, potassium salt, calcium salt, magnesium salt, and ammonium salt; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt, and diisopropylammonium salt; and basic amino acid salts such as arginine salt. In particular, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0051] Examples of alkyl sulfates include lauryl sulfate (sodium lauryl sulfate) and myristoyl sulfate. Examples of acyl amino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate, and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methylglycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-methyl-N-acyl alanine salt; and acyl aspartates such as lauroyl aspartate salt. Examples of acyl taurine salts include lauroyl methyl taurine salt, N-methyl-N-acyl taurine salt, and N-cocoyl methyl taurine salt. Examples of α-olefin sulfonates include α-olefin sulfonates with 12 to 18 carbon atoms, such as tetradecene sulfonate. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride monosulfate sodium and lauryl sulfoacetate sodium.

[0052] For anionic surfactants, it is preferable to use anionic surfactants containing sulfonic acid groups in terms of foaming ability and foam quality, and it is more preferable to use alkyl sulfates and α-olefin sulfonates.

[0053] Examples of cationic surfactants include quaternary ammonium salt type cationic surfactants and amino acid-based cationic surfactants. Examples of quaternary ammonium salts include alkylpyridinium salts, benzethonium salts, benzalkonium salts, monoalkyltrimethylammonium salts, and dialkyldimethylammonium salts. Examples of salts include chloride salts and bromide salts. Examples of alkyl groups in alkylpyridinium salts, monoalkyltrimethylammonium salts, or dialkyldimethylammonium salts include alkyl groups having 8 to 22 carbon atoms. The upper or lower limit of the number of carbon atoms may be, for example, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21. More specifically, it may be, for example, 9 to 21. Examples of quaternary ammonium salt type cationic surfactants include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, distearyldimethylammonium chloride, laurylbenzyldimethylammonium chloride, hexadecyltrimethylammonium bromide, and stearyltrimethylammonium bromide. Examples of amino acid-based cationic surfactants include mono-N-long-chain acyl basic amino acid lower alkyl ester salts. Examples of basic amino acids constituting amino acid-based cationic surfactants include natural amino acids such as ornithine, lysine, and arginine. Synthetic amino acids such as α,γ-diaminobutyric acid can also be used. These may be optically active or racemic. The acyl group of the mono-N-long-chain acyl basic amino acid lower alkyl ester salt is preferably a saturated or unsaturated higher fatty acid residue with 8 to 22 carbon atoms. The upper or lower limit of the number of carbon atoms may be, for example, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21. More specifically, it may be 9 to 21. Examples include single higher fatty acid residues such as lauroyl group, myristoyl group, palmitoyl group, and stearoyl group; and natural mixed higher fatty acid residues such as coconut oil fatty acid residues and beef tallow higher fatty acid residues. Examples of lower alkyl esters include alkyl esters having 1 to 8 carbon atoms. Specifically, these include methyl esters, ethyl esters, propyl esters, butyl esters, pentyl esters, hexyl esters, heptyl esters, and octyl esters. Lower alkyl esters are preferably in salt form, and examples include inorganic salts such as hydrochloride, bromate, sulfate, and phosphate; and organic salts such as glycolate, acetate, lactate, succinate, tartrate, citrate, acidic amino acid salts, higher fatty acid salts, L- or DL-pyrrolidone carboxylate salts, pyroglutamate, and p-toluenesulfonate. Examples of amino acid-based cationic surfactants include N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate.

[0054] In this embodiment, the content of the optional surfactant is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.1% by mass or more, preferably 10% by mass or less, and even more preferably 5% by mass or less, when the total amount of the toothpaste composition is 100% by mass. Therefore, the content of the optional surfactant is preferably 0.001% by mass to 10% by mass, preferably 0.01% by mass to 5% by mass, and even more preferably 0.1% by mass to 5% by mass. The content of the optional surfactant can be independent of the content of component (B) and / or component (C).

[0055] -Sweetener- The toothpaste composition of this embodiment may contain a sweetener in an optionally suitable amount, as long as it does not impair the effects of the present invention.

[0056] Examples of sweeteners include aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartin, thaumatin, and aspartylphenylalanine methyl ester. The sweeteners listed above may be used individually, in combination of two or more, or commercially available products may be used.

[0057] -Fragrance (Fragrance composition)- The toothpaste composition of this embodiment may contain a conventionally known, optionally suitable fragrance (fragrance composition) in an optionally suitable amount. Including a fragrance in the toothpaste composition can further improve the user experience.

[0058] As fragrances, for example, natural essential oils such as peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, rose oil, iris oil, thyme oil, sage oil, cardamom oil, coriander oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, grapefruit oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, paraclete oil, vanilla oil, cinnamon oil, pimento oil, cinnamon leaf oil, and perilla oil; menthol, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, Fragrance components contained in the above natural essential oils, such as camphor, borneol, pinene, spiranthol, menthyl succinate, n-decyl alcohol, citronellol, α-terpineol, menthofran, linalool oxide, vanillyl butyl ether, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol (3-octanol), octanal (3-octanal), octyl acetate (3-octyl acetate), caryophyllene (caryophyllene-BE), germacrene (germacrene D), viridiflorol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, carone, methyl jasmonate, citronellyl acetate, and ethyl linalool;Ethyl acetate, ethyl butyrate, ethyl-2-methyl butyrate, isoamyl acetate, hexanal, hexenal (trans-2-hexenal), hexyl acetate, methyl anthranilate, ethylmethylphenyl glycidate, benzyl alcohol, benzaldehyde, maltol, ethyl maltol, vanillin, ethyl vanillin, furaneol, ethylcyclopentenone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, p-methoxycinnamic aldehyde, cis-3-hexenol, undecalactone, decalactone, N-ethyl-p-menthane-3-carboxamide, N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, Fragrance components such as N-[(ethoxycarbonyl)methyl]-p-menthane-3-carboxamide, Np-benzeneasotonitrile menthanecarboxamide, N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophen-2-ylmethyl)acetamide, N-(4-methoxyphenyl)-p-menthanecarboxamide, menthyl glyceryl ether, menthyl lactate, ethylene glycol-l-menthyl carbonate, etc.; plant extracts such as vanilla extract, chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, cardamom extract, etc.In addition, various blended flavors such as mint, fruit, and herb, which are made by combining several fragrance components and natural essential oils, can be mentioned. Furthermore, fragrances that can also function as cooling agents include, for example, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, menthyl monosuccinate, isopulegol, menthol glycoside ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-l-mentoxypropane-1,2-diol, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3-carboxamide Other examples include ethyl acetate (Samide), 2-isopropyl-N,2,3-trimethylbutylamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, menthyl glutarate, 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophen-2-ylmethyl)acetamide, and isopuregol. As for the fragrance, one of the above example fragrances may be used alone, two or more may be used in combination (as a fragrance composition), and commercially available products may also be used. If the oral composition contains a fragrance (fragrance composition), its content is preferably 0.0000001% to 5% by mass, more preferably 0.00001% to 3% by mass, and even more preferably 0.01% to 2% by mass, based on 100% by mass of the total amount of the oral composition. If the oral composition contains a fragrance that can also function as a cooling agent, its content is preferably 0.00001% to 0.01% by mass, based on 100% by mass of the total amount of the oral composition. Furthermore, when these fragrances are combined to form a fragrance composition, a solvent may be used. Examples of such solvents include ethanol, propylene glycol, glycerin fatty acid esters, and triacetin.

[0059] -Medicinal ingredients- Medicinal ingredients include, for example, enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, azulene, sodium azulene sulfonate, glycyrrhizic acid or its salts (e.g., dipotassium glycyrrhizate), glycyrrhetinic acid or its salts (e.g., stearyl glycyrrhetinate), Phellodendron amurense, and Phellodendron amurense extract; cell activators such as sodium chloride and vitamins; and bactericidal or antibacterial agents such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, thymol, lysozyme chloride, chlorhexidine, triclosan, zinc gluconate, and zinc citrate. Examples of medicinal toothpaste compositions include: water-soluble copper compounds such as copper chlorophyll and copper gluconate; tartar preventatives such as zeolites, ethane hydroxydiphosphonates, and polyphosphates (e.g., sodium polyphosphate); vitamins such as vitamin C (e.g., ascorbic acid) and vitamin E (e.g., vitamin E other than component (F), such as tocopherol); astringents such as sodium chloride, alum, and lysozyme chloride; hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; amino acids such as alanine, glycine, proline, arginine, lysine, glutamine, and cysteine; peptides such as caropeptides; fluoride compounds such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride; and plant extracts such as thyme, scutellaria baicalensis, clove, and witch hazel. When a toothpaste composition contains medicinal ingredients, the amount can be an effective amount within a range that does not hinder the effects of the present invention (a range that is pharmacologically acceptable). The medicinal ingredients may be used individually from the above list, in combination of two or more, or commercially available products may be used.

[0060] -Oily components- The toothpaste composition of this embodiment may contain conventionally known and suitable oily components in an arbitrarily suitable amount. Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. As for the oily components, one of the above oily components may be used alone, two or more may be used in combination, and commercially available products may be used.

[0061] - Preservatives - The toothpaste composition of this embodiment may contain a conventionally known, suitable preservative in a suitably appropriate amount. By including a preservative in the toothpaste composition, preservative properties can be imparted to the toothpaste composition.

[0062] Examples of preservatives that the toothpaste composition may contain include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, etc. The preservative may be used alone, in combination of two or more, or a commercially available product may be used.

[0063] -Wetting agent- The toothpaste composition of this embodiment may contain a conventionally known and suitable wetting agent in a suitably appropriate amount. By including a suitable wetting agent in the toothpaste composition, the user experience can be further improved.

[0064] As a wetting agent, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include sugar alcohols such as sorbitol, lactitol, and reduced starch syrup; glycerin; and polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycol include polyethylene glycol with an average molecular weight of 150 to 6000, and preferably polyethylene glycol with an average molecular weight of 190 to 4000. Specifically, examples include PEG200, PEG300, PEG400, PEG600, PEG4000, etc. As a wetting agent, one of the above wetting agents may be used alone, two or more may be used in combination, or commercially available products may be used. The average molecular weight is the average molecular weight described in the 2021 Japanese Standards for Raw Materials of Quasi-Drugs. If the toothpaste composition may contain a wetting agent, the amount thereof is preferably 1% to 70% by mass, more preferably 1% to 65% by mass, even more preferably 1% to 60% by mass, and still more preferably 3% to 60% by mass, when the total amount of the toothpaste composition is 100% by mass.

[0065] -Abrasive- Either inorganic or organic abrasives may be used as the abrasive. Examples of inorganic abrasives include calcium hydroxide, aluminum hydroxide, trimagnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite. Examples of organic abrasives include synthetic resin-based abrasives and polymethyl methacrylate. The above abrasives may be used individually, in combination of two or more, or commercially available products may be used.

[0066] The amount of abrasive is preferably 5.0 to 70% by mass, and more preferably 10 to 50% by mass, when the total amount of the toothpaste composition is considered to be 100% by mass.

[0067] - Binding agent - The toothpaste composition of this embodiment may contain a binder.

[0068] Examples of binders that can be included in toothpaste compositions include conventionally known and suitable organic binders, such as polysaccharides, cellulosic binders (e.g., carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, etc., and pharmaceutically acceptable salts thereof such as their sodium salts), other polysaccharide thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Furthermore, conventionally known and suitable inorganic binders may also be included. One or more of the above-exemplary binders can be included as binders, and commercially available products can also be used.

[0069] The binder content is preferably greater than 0% by mass, more preferably 0.001% by mass or more, and even more preferably 0.01% by mass or more, when the total amount of the toothpaste composition is considered as 100% by mass. Furthermore, the binder content is preferably 11% by mass or less, and more preferably 10% by mass or less. Therefore, the binder content is preferably greater than 0% by mass and 11% by mass or less, and more preferably between 0.01% by mass and 10% by mass.

[0070] - pH adjuster - The toothpaste composition of this embodiment may contain a conventionally known and suitable pH adjusting agent in a suitably suitable amount. By including a pH adjusting agent in the toothpaste composition, pH stability can be provided.

[0071] Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, tartaric acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate); inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic salts include disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, sodium carbonate, and sodium bicarbonate. As a pH adjuster, one of the above pH adjusters may be used alone, two or more may be used in combination, or commercially available products may be used.

[0072] The amount of pH adjuster can be such that the pH of the toothpaste composition after the addition of the pH adjuster is preferably 5.0 to 9.0, and more preferably 5.5 to 8.5.

[0073] In this specification, the pH value refers to the value obtained 3 minutes after the start of measurement at 25°C. The pH value can be measured using, for example, a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

[0074] -Coloring agent- The toothpaste composition of this embodiment may contain a conventionally known and suitable coloring agent in a suitably suitable amount.

[0075] Examples of colorants that the toothpaste composition may contain include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red yeast rice pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cocoa pigment, spirulina blue pigment, and tamarind pigment, as well as legally approved colorants such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1, and riboflavin, copper chlorophyll sodium, and titanium dioxide. As colorants, one of the above colorants may be used alone, two or more may be used in combination, and commercially available products may be used. When the toothpaste composition contains a colorant, its content is preferably 0.00001% to 3% by mass when the total amount of the toothpaste composition is 100% by mass.

[0076] -Other optional components- The toothpaste composition of this embodiment may contain other optional components in an optionally suitable amount.

[0077] In this embodiment, examples of other optional components that the toothpaste composition may contain include inorganic compounds such as titanium mica, magnesium oxide, and zirconium oxide; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; calcium compounds such as calcium glycerophosphate; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; and polyisobutylene, polybutadiene, urethane, silicone, and natural rubber.

[0078] Other optional components may be used individually, in combination of two or more, or commercially available products may be used. The content of these other optional components can be appropriately set within a range that does not interfere with the effects of the present invention.

[0079] [Dosage form] The toothpaste composition of this embodiment may include toothpaste compositions that are in the form of a paste, gel, or cream. The toothpaste composition of this embodiment is preferably in the form of a paste or gel.

[0080] In this embodiment, the pH (at 25°C) of the toothpaste composition is preferably 5.0 to 9.0. The pH can be adjusted by adding a pH adjusting agent, changing the component composition, etc.

[0081] The toothpaste composition of this embodiment can be adjusted to an appropriate viscosity depending on the dosage form, for example. When the dosage form is paste, gel, or cream, the viscosity at 25°C measured with a BH viscometer is preferably 1 Pa·s to 300 Pa·s, and more preferably 20 Pa·s to 150 Pa·s.

[0082] [Method for producing toothpaste composition] The method for producing the toothpaste composition of this embodiment is not particularly limited. The toothpaste composition can be produced by any suitable conventionally known method. Specifically, a method for producing the toothpaste composition may involve first preparing components that dissolve in a solvent, then mixing in other insoluble components, and, if necessary, degassing by, for example, reducing pressure.

[0083] The toothpaste composition obtained in this way can be made into a product by placing it in a predetermined container (laminated tube).

[0084] The shape and material of the container in which the toothpaste composition of the present invention can be contained are not particularly limited. Any suitable conventionally known container that is normally applied to toothpaste compositions can be used as the container. Examples of containers include plastic containers made of polyethylene, polypropylene, polyethylene terephthalate, and nylon. [Examples]

[0085] The present invention will be specifically described below with reference to examples and comparative examples. The present invention is not limited to these examples. Unless otherwise specified, the numerical values ​​described in these examples (including the values ​​in the table below) represent mass percent.

[0086] [Components used in the examples and comparative examples] First, we will explain the components used in the examples and comparative examples. -(A) Ingredients: Pyridoxine or its salt- (A1) Pyridoxine hydrochloride (Kyowa Pharma Chemical Co., Ltd. "Pyridoxine Hydrochloride")

[0087] -(B) Ingredient: Nonionic surfactant- (B1) Polyoxyethylene hydrogenated castor oil (5) (EMALEX HC-5 manufactured by Nippon Emulsion Co., Ltd.) (B2) Polyoxyethylene hydrogenated castor oil (20) (Aoki Oil Co., Ltd. "Brownon RCW-20") (B3) Polyoxyethylene stearyl ether (20) (Aoki Oil Co., Ltd. "Brownon SR-720") (B4) Sorbitan monostearate (Sorbitan monostearate manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) (B5) Decaglyceryl laurate (manufactured by Nikko Chemicals Co., Ltd. as "NIKKOL Decaglyn 1-L") (B6) Sucrose stearate ester ("Ryoto Sugar Ester S-1570" manufactured by Mitsubishi Chemical Corporation) (B7) Polyoxyethylene (20) sorbitan monostearate (Kao Corporation's "Leodor TW-S120V")

[0088] -(C) Ingredients: Amphoteric surfactant- (C1) Coconut oil fatty acid amidopropyl betaine (EVONIK "Tego Betaine CK OK (30%)")

[0089] -(D) Component: Inorganic powder- (D1) Abrasive anhydrous silicic acid (abrasive silica) (Zeodent 124, manufactured by EVONIK Co., Ltd.) (D2) Thickening anhydrous silicic acid (thickening silica) ("Carplex #67Q (liquid absorption capacity: 2.3)" manufactured by DSL Japan Co., Ltd.)

[0090] -(E) Component- (E1) Sodium saccharin (Sodium saccharin manufactured by Aisan Chemical Industry Co., Ltd.) (E2) Xylitol (manufactured by Mitsubishi Corporation Life Sciences Co., Ltd.)

[0091] -(F) component- (F1) Tocopherol acetate (dl-α-tocopherol acetate, manufactured by DSM Nutrition Japan)

[0092] - Optional components (components other than components (A) to (F)) 70% sorbitol (D-Sorbitol Solution, manufactured by Mitsubishi Corporation Life Sciences Co., Ltd.) Propylene glycol ("Cosmetic-grade Propylene Glycol" manufactured by ADEKA Corporation) Sodium lauryl sulfate (BASF Japan Ltd. "TEXAPON OC-P") Sodium carboxymethylcellulose (CMC1260, manufactured by Daicel Mirise Co., Ltd.) fragrance composition purified water

[0093] The compositions of fragrance compositions A to S used in the examples, comparative examples, and formulation examples are shown in Tables 1 and 2 below.

[0094] [Table 1]

[0095] [Table 2]

[0096] The compositions of flavors 1 to 7 and solvents used in the above-mentioned fragrance compositions A to S are shown in Tables 3 to 10 below.

[0097] [Table 3]

[0098] [Table 4]

[0099] [Table 5]

[0100] [Table 6]

[0101] [Table 7]

[0102] [Table 8]

[0103] [Table 9]

[0104] [Table 10]

[0105] Examples 1-45 and Comparative Examples 1-6 Using the above ingredients as raw materials, toothpaste compositions having the formulations shown in Tables 11 to 17 below were prepared.

[0106] [Preparation of toothpaste composition] The raw materials shown in Tables 11-17 were blended by conventional methods to obtain toothpaste compositions. The obtained toothpaste compositions were then placed in any suitable conventionally known container (laminated tube).

[0107] The obtained toothpaste compositions (Examples 1-45 and Comparative Examples 1-6) were evaluated using the following evaluation method. The evaluation results are shown in Tables 11-17 below.

[0108] [Evaluation Method] (1) Evaluation of the astringent sensation of the oral mucosa during tooth brushing Ten expert panelists conducted a sensory evaluation of the presence and degree of astringency in the oral mucosa during toothbrushing. Each participant was asked to apply 1 cm of the toothpaste composition (filled in a laminate tube) described in the previously mentioned examples and comparative examples to a toothbrush and brush their teeth for 3 minutes using their usual method. The astringency felt in the oral mucosa during brushing was evaluated according to the scoring criteria shown below. The average score from the ten expert panelists was calculated and judged on a 5-point scale (A, B, C, D, and E) according to the evaluation criteria below. A score of C or higher (A, B, and C) was considered a pass. (Scoring Criteria) 5 points: I feel a very strong astringent sensation in my mouth. 4 points: I felt a strong astringent sensation in my mouth. 3 points: There is a constricting sensation in the mouth. 2 points: There is a slight astringent sensation in the mouth. 1 point: No astringent feeling in the mouth. (Evaluation Criteria) A: Average score of 4.5 points or more B: Average score of 4.0 or higher but less than 4.5 C: Average score between 3.0 and 4.0 D: Average score between 2.0 and 3.0 E: Average score between 1.0 and 2.0 points

[0109] (2) Evaluation of discoloration over time The toothpaste compositions described in the examples and comparative examples were visually observed and evaluated for their appearance (discoloration and its degree) after being stored for one month at 60°C and -5°C. Specifically, the discoloration (or lack thereof) of the toothpaste composition stored at 60°C for one month was evaluated using the following scoring criteria, with the toothpaste composition stored at -5°C for one month used as a baseline. The average score obtained from a total of five similar tests was calculated and evaluated according to the following five-level evaluation criteria. Here, a score of C or higher (A, B, and C) was determined to be acceptable. (Scoring Criteria) 5 points: No discoloration at all. 4 points: There is a very slight discoloration to a pale yellow, but it is hardly noticeable. 3 points: There is a slight discoloration to a light yellow, but it is not noticeable during use. Two points: There is discoloration from dark yellow to brownish-red. 1 point: Discoloration to a dark reddish-brown color. (Evaluation Criteria) A: Average score of 4.5 points or more B: Average score of 4.0 or higher but less than 4.5 C: Average score between 3.0 and 4.0 D: Average score between 2.0 and 3.0 E: Average score less than 2.0 points

[0110] (3) Evaluation of irritation after brushing teeth A sensory evaluation was conducted by 10 expert panelists regarding the presence and degree of irritation after brushing. The toothpaste compositions described in the examples and comparative examples were extruded 1 cm onto a toothbrush and brushed for 3 minutes using the usual method. The presence and degree of oral mucosal irritation felt after brushing were evaluated according to the scoring criteria shown below. The average score from the 10 expert panelists was calculated and judged on a 5-point scale (A, B, C, D, and E) according to the evaluation criteria below. A score of C or higher (A, B, and C) was considered a pass. (Scoring Criteria) 4 points: No stimulation at all 3 points: Almost no irritation 2 points: Slightly stimulating 1 point: Stimulating (Evaluation Criteria) A: Average score 4.0 points B: Average score between 3.5 and 4.0 C: Average score between 3.0 and 3.5 points D: Average score between 2.0 and 3.0 E: Average score less than 2.0 points

[0111] (4) Evaluation of sarcastic remarks while brushing teeth A sensory evaluation was conducted by 10 expert panelists to assess the presence and degree of unpleasantness during toothbrushing. The toothpaste compositions described in the previously mentioned examples and comparative examples were extruded 1 cm onto a toothbrush and used for 3 minutes of normal brushing. The presence and degree of unpleasantness felt during brushing were then evaluated according to the following scoring criteria. The average score from the 10 expert panelists was calculated and judged on a 5-point scale (A, B, C, D, and E) according to the evaluation criteria below. A score of C or higher (A, B, and C) was considered a pass. (Scoring Criteria) 4 points: Not offensive at all. 3 points: Almost no sarcasm. 2 points: Slightly sarcastic. 1 point: It's sarcastic. (Evaluation Criteria) A: Average score 4.0 points B: 3.5 points or higher, less than 4.0 points C: 3.0 points or higher, less than 3.5 points D: 2.0 points or higher, less than 3.0 points E: Less than 2.0 points

[0112] [Table 11]

[0113] [Table 12]

[0114] [Table 13]

[0115] [Table 14]

[0116] [Table 15]

[0117] [Table 16]

[0118] [Table 17]

[0119] In Examples 1 to 45, which used predetermined amounts of components (A) and (B), the evaluation of both the astringent sensation of the oral mucosa during brushing and the discoloration over time was good. Furthermore, in Examples 19 to 45, which further included either or both of components (C) and (D), the irritation after brushing was also effectively reduced, and in particular, when both components (C) and (D) were included, the irritation after brushing was reduced more effectively. Furthermore, in Examples 32 to 45, which further included either or both of components (E) and (F), the unpleasant taste during brushing was effectively reduced, and in particular, when both components (E) and (F) were included, the unpleasant taste during brushing was reduced more effectively. On the other hand, in Comparative Examples 1 to 6, which did not satisfy any of the requirements of the present invention, at least one of the astringent sensation of the oral mucosa during brushing and the discoloration over time was inferior.

[0120] (Example prescription) Examples of toothpaste compositions to which the present invention is applied are shown below. In each example, the units of the numerical values ​​indicated as content are "mass%".

[0121] In the following prescription examples 1-43, both the astringent sensation of the oral mucosa during brushing and the discoloration over time were evaluated favorably.

[0122] Formulation Example 1: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.5 Coconut oil fatty acid amidopropyl betaine solution*3 0.5 Polishable silica*1 18 Thickening silica*2 3 Titanium dioxide 0.4 Sodium saccharin 0.2 Sodium fluoride 0.32 Sodium polyphosphate 1 Sodium lauryl sulfate 1.5 Sodium lauroyl sarcosinate 0.1 Propylene glycol 4 Sodium bicarbonate 0.2 70% sorbitol solution 25 Xanthan gum 1.6 Sodium polyacrylate 0.2 Methylparaben 0.2 Sodium hydroxide (48% solution) 0.2 Fragrance composition A 1.2 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0123] Formulation Example 2: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1 Polishable silica*1 22 Thickening silica*2 1 Titanium dioxide 0.4 Aluminum Oxide 2 Sodium saccharin 0.2 Sodium fluoride 0.32 Sodium pyrophosphate 0.5 Sodium lauryl sulfate 1 Sodium lauroyl sarcosinate 0.1 Propylene glycol 3 Polyethylene glycol 400 2.5 Sodium bicarbonate 0.5 70% sorbitol solution 30 Xanthan gum 0.8 Sodium polyacrylate 0.5 Methylparaben 0.2 Sodium hydroxide (48% solution) 0.2 Fragrance composition A 1.2 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0124] Formulation Example 3: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.8 Heavy calcium carbonate 50 Thickening silica*1 2 Aluminum Oxide 1 Sodium saccharin 0.1 Mannitol 0.5 Stannous fluoride 0.6 Sodium lauryl sulfate 1.5 Polyethylene glycol 400 1 Propylene glycol 3 70% sorbitol solution 20 Sodium carboxymethylcellulose*2 1 Methylparaben 0.2 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0125] Formulation Example 4: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.3 Heavy calcium carbonate 35 Thickening silica*4 5 Sodium saccharin 0.2 Sucralose 0.002 Sodium monofluorophosphate 1.1 Sodium lauryl sulfate 1.8 Propylene glycol 3 70% sorbitol solution 25 Sodium carboxymethylcellulose*1 0.6 Sodium carboxymethylcellulose*2 0.2 Sodium carboxymethylcellulose*3 0.4 Sodium polyacrylate 0.2 Methylparaben 0.2 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1250" manufactured by Daicel Mirise Co., Ltd. *4 Carboxymethylcellulose sodium: "CMC1220" manufactured by Daicel Mirise Co., Ltd.

[0126] Formulation Example 5: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.1 Heavy calcium carbonate 20 Aluminum oxide 0.4 Thickening silica*1 5.5 Titanium dioxide 0.5 Sodium saccharin 0.2 Xylitol 7 Mannitol 0.3 Sodium monofluorophosphate 1.1 Sodium lauryl sulfate 2 Sodium lauroyl sarcosinate 0.1 70% sorbitol solution 25 Propylene glycol 3 Sodium carboxymethylcellulose*2 1.5 Methylparaben 0.2 Fragrance composition A 1.5 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0127] Formulation Example 6: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 1.5 Polishable silica*1 15 Thickening silica*2 5 Titanium dioxide 0.4 Sodium saccharin 0.15 Mannitol 0.2 Sucralose 0.02 Sodium fluoride 0.32 Sodium tetradecenesulfonate 0.3 Sodium lauryl sulfate 0.3 70% sorbitol solution 40 Propylene glycol 3 Polyethylene glycol 4000 0.2 Xanthan gum 0.5 Sodium alginate 0.5 Sodium polyacrylate 0.2 Hydroxyethylcellulose Dimethyldiallylammonium chloride 0.05 Benzalkonium chloride 0.01 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.7)" manufactured by DSL Japan Co., Ltd.

[0128] Formulation Example 7: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1 Polyoxyethylene (5) stearyl ether 1 Decaglycerin fatty acid ester 0.2 Coconut oil fatty acid amidopropyl betaine 2 Polishable silica*2 18 Thickening silica*3 6 Titanium dioxide 1 Sodium saccharin 0.2 Mannitol 0.2 Sodium fluoride 0.32 Dextranase*1 0.2 (Enzyme activity per gram of preparation: 20 U) Sodium polyphosphate 0.5 Sodium lauryl sulfate 0.7 Sodium tetradecenesulfonate 0.3 Sodium lauroyl sarcosinate 0.2 70% sorbitol solution 40 Propylene glycol 3 Polyethylene glycol #4000 1 Xanthan gum 0.5 Carrageenan 0.5 Sodium alginate 0.2 Hydroxyethylcellulose Dimethyldiallylammonium chloride 0.05 DL-Alanine 0.15 Fragrance composition A 1.3 Water balance Total 100 *1 Dextranase: Dextranase 2F (enzyme activity 4000 U / g) manufactured by Mitsubishi Chemical Corporation. *2 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *3 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.7)" manufactured by DSL Japan Co., Ltd.

[0129] Formulation Example 8: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 2 Polyoxyethylene(5) stearyl ether 1.5 Decaglycerin fatty acid ester 0.1 Coconut oil fatty acid amidopropyl betaine 2 Polishable silica*2 10 Thickening silica*3 1 Thickening silica*4 2 Titanium dioxide 0.4 Sodium saccharin 0.1 Mannitol 0.5 Tocopherol acetate 0.1 Sodium fluoride 0.32 Dextranase*1 0.2 (Enzyme activity per gram of preparation: 20 U) Potassium nitrate 5 Sodium lauryl sulfate 0.5 Sodium lauroyl sarcosinate 0.1 Sodium tetradecenesulfonate 0.5 Propylene glycol 5 70% sorbitol solution 45 Xanthan gum 1 Sodium alginate 0.8 Sodium polyacrylate 0.6 Hydroxyethylcellulose Dimethyldiallylammonium chloride 1 Sodium pyrrolidonecarboxylate 3 DL-Alanine 0.1 Fragrance composition A 1.3 Water balance Total 100 *1 Dextranase: Dextranase 2F (enzyme activity 4000 U / g) manufactured by Mitsubishi Chemical Corporation. *2 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *3 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.7)" manufactured by DSL Japan Co., Ltd. *4 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd.

[0130] Formulation Example 9: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 2.5 Polyoxyethylene(5) stearyl ether 1.5 Decaglycerin fatty acid ester 0.1 Coconut oil fatty acid amidopropyl betaine 1 Polishable silica*2 10 Thickening silica*3 2 Thickening silica*4 0.5 Titanium dioxide 0.4 Sodium saccharin 0.12 Xylitol 3 Mannitol 0.3 Tocopherol acetate 0.1 Sodium fluoride 0.32 Potassium nitrate 5 Dextranase*1 0.2 (Enzyme activity per gram of preparation: 20 U) Sodium lauroyl sarcosinate 0.1 Sodium tetradecenesulfonate 1 Propylene glycol 5 70% sorbitol solution 45 Xanthan gum 1.5 Sodium alginate 0.2 Sodium polyacrylate 0.2 Hydroxyethylcellulose Dimethyldiallylammonium chloride 0.1 DL-Alanine 0.2 Fragrance composition A 1.3 Water balance Total 100 *1 Dextranase: Dextranase 2F (enzyme activity 4000 U / g) manufactured by Mitsubishi Chemical Corporation. *2 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *3 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.7)" manufactured by DSL Japan Co., Ltd. *4 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd.

[0131] Formulation Example 10: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.5 Polyoxyethylene (5) stearyl ether 0.5 Polishable silica*1 15 Thickening silica*2 5 Titanium dioxide 0.1 Sodium saccharin 0.2 Sodium lauryl sulfate 1.4 Sodium lauroyl sarcosinate 0.2 Sodium fluoride 0.32 β-Glycyrrhetinic acid 0.01 Isopropylmethylphenol 0.1 70% sorbitol solution 35 Propylene glycol 3 Polyethylene glycol 4000 0.5 Xanthan gum 0.7 Sodium alginate 0.3 Sodium polyacrylate 0.5 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: "Zeodent 124" manufactured by EVONIK Corporation *2 Viscosity - increasing silica: "Carplex #67Q (liquid absorption amount 2.4)" manufactured by DSL Japan Co., Ltd.

[0132] Formulation example 11: Toothpaste composition Pyridoxine hydrochloride 0.0₂ Polyoxyethylene (20) hydrogenated castor oil 0.75 Polyoxyethylene (5) stearyl ether 0.75 Abrasive silica *1 15 Viscosity - increasing silica *2 5 Titanium oxide 0.4 Saccharin sodium 0.18 Xylitol 0.5 Sodium lauryl sulfate 1.2 Sodium fluoride 0.32 β - Glycyrrhetinic acid 0.01 Isopropylmethylphenol 0.05 70% Sorbitol solution 35 Sodium carboxymethyl cellulose *3 1.4 Sodium polyacrylate 0.4 Fragrance composition A 1.2 Water balance Total 100 *1 Abrasive silica: "Zeodent 124" manufactured by EVONIK Corporation[[ID=​​​​​​​​Pyridoxine hydrochloride 0.02 Polyoxyethylene(5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 0.3 Abrasive silica *1 10 Viscosity increasing silica *2 6 Titanium oxide 0.05 Saccharin sodium 0.18 Tocopherol acetate 0.2 Sodium fluoride 0.32 Tranexamic acid 0.05 Isopropyl methylphenol 0.05 Sodium lauroyl methyltaurine 0.6 Sodium lauryl sulfate 0.2 85% Glycerin 40 Xanthan gum 0.5 Carboxymethyl cellulose sodium *3 1.5 Sodium polyacrylate 0.3 Citric acid 0.5 Sodium citrate 0.5 Sodium sulfate anhydrous 0.5 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: "Zeodent 124" manufactured by EVONIK Corporation *2 Viscosity increasing silica: "Carplex #67Q (liquid absorption amount 2.4)" manufactured by DSL Japan Co., Ltd. *3 Carboxymethyl cellulose sodium: CMC1260 of Daicel Miraiz Co., Ltd.

[0134] Formulation example 13: Toothpaste composition Pyridoxine hydrochloride 0.02 Polyoxyethylene(5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 0.6 Abrasive silica *1 10 Viscosity increasing silica *2 4.5 Titanium oxide 0.01 Sodium saccharin 0.2 Xylitol 1 Sucralose 0.005 Tocopherol acetate 0.1 Sodium fluoride 0.32 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Dipotassium glycyrrhizinate 0.1 Sodium lauroyl methyltaurine 0.8 Sodium lauryl sulfate 0.1 85% Glycerin 20 70% Sorbitol solution 20 Xanthan gum 0.2 Sodium carboxymethyl cellulose*3 1.8 Sodium polyacrylate 0.3 Citric acid 0.5 Sodium citrate 0.5 Sodium sulfate anhydrous 1 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: "Zeodent 124" manufactured by EVONIK Corporation *2 Viscosity - increasing silica: "Carplex #67Q (liquid absorption amount 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethyl cellulose: "CMC1260" manufactured by Daicel Miraiz Co., Ltd.

[0135] Formulation example 14: Toothpaste composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 2 Coconut oil fatty acid amide propyl betaine 1 Abrasive silica*1 8 Titanium oxide 0.5 Viscosity - increasing silica*3 6 Sodium saccharin 0.18 Tocopherol acetate 0.1 Sodium fluoride 0.32 Potassium nitrate 5 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium lauroyl methyl taurate 0.7 70% sorbitol solution 40 Sodium carboxymethylcellulose*2 2 Xanthan gum 0.5 Citric acid 0.25 Sodium citrate 0.5 Fragrance composition A 1.3 Methylparaben 0.2 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0136] Formulation Example 15: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 2 Polishable silica*1 12 Thickening silica*2 2 Titanium dioxide 0.4 Sodium saccharin 0.15 Tocopherol acetate 0.1 Sodium fluoride 0.32 Sodium polyphosphate 1 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium lauroyl methyl taurate 1.5 70% sorbitol solution 50 Sodium carboxymethylcellulose*3 1.5 Sodium polyacrylate 0.5 Fragrance composition A 1.3 Methylparaben 0.2 Anhydrous sodium sulfate 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0137] Formulation Example 16: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 1 Polishable silica*1 10 Thickening silica*2 5 Sodium saccharin 0.15 Tocopherol acetate 0.1 Sodium fluoride 0.32 Tranexamic acid 0.05 Potassium nitrate 5 Isopropylmethylphenol 0.05 Sodium polyphosphate 1 Sodium lauroyl methyl taurate 0.2 70% sorbitol solution 40 Sodium carboxymethylcellulose*3 1.4 Xanthan gum 0.5 Citric acid 0.25 Sodium citrate 0.5 Titanium mica 0.5 Yellow No. 5 0.00025 Fragrance composition A 1.3 Methylparaben 0.15 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0138] Formula Example 17: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine 2.5 Polishable silica*1 15 Thickening silica*2 8 Titanium dioxide 0.05 Sodium saccharin 0.2 Tocopherol acetate 0.1 Sodium fluoride 0.32 Tranexamic acid 0.05 Potassium nitrate 5 Isopropylmethylphenol 0.05 Sodium pyrophosphate 0.5 Sodium Lauroyl Methyl Taurate 1 85% Glycerin 30 Propylene glycol 3 Propylene glycol alginate 0.1 Xanthan gum 0.4 Sodium carboxymethylcellulose*3 1.2 Sodium polyacrylate 0.3 Titanium mica 0.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0139] Formulation Example 18: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1 Polyoxyethylene (5) stearyl ether 1 Heavy calcium carbonate 20 Thickening silica*1 4 Sodium saccharin 0.1 Xylitol 5 Mannitol 0.1 Tocopherol acetate 0.1 Sodium monofluorophosphate 1.1 β-Glycyrrhetinic acid 0.02 Tranexamic acid 0.05 Sodium lauryl sulfate 0.8 Sodium lauroyl sarcosinate 0.1 Benzalkonium chloride 0.01 Sodium carboxymethylcellulose*2 1 Sodium polyacrylate 0.3 70% sorbitol solution 55 Propylene glycol 3 Polyethylene glycol 4000 0.5 Scutellaria baicalensis extract 0.005 Carrot extract 0.001 Phellodendron bark extract 0.05 Rosemary extract 0.001 Sage extract 0.001 Tea extract 0.001 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0140] Formulation Example 19: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.6 Polyoxyethylene(5) stearyl ether 0.6 Coconut oil fatty acid amidopropyl betaine solution*3 1 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 1 Sodium saccharin 0.1 Tocopherol acetate 0.1 Sodium monofluorophosphate 1.1 Aluminum lactate 2 Isopropylmethylphenol 0.1 Tranexamic acid 0.1 Potassium nitrate 5 Sodium chloride 1 Sodium Lauroyl Methyl Taurate 1 70% sorbitol solution 32 Propylene glycol 5 Polyethylene glycol 4000 0.5 Xanthan gum 0.3 Carrageenan 0.9 Sodium alginate 0.9 Sodium hydroxide 0.1 Sodium dihydrogen phosphate 1 Methylparaben 0.2 Fragrance composition A 1.5 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0141] Formulation Example 20: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1.5 Polyoxyethylene(5) stearyl ether 1.5 Coconut oil fatty acid amidopropyl betaine solution*3 1 Polishable silica*1 10 Thickening silica*2 6 Titanium dioxide 0.1 Sodium saccharin 0.1 Tocopherol acetate 0.1 Sodium monofluorophosphate 1.1 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Copper gluconate 0.1 Sodium lauryl sulfate 1.5 Sodium lauroyl sarcosinate 0.2 Sodium lauroyl methyl taurate 1.2 85% Glycerin 45 Propylene glycol 3 Polyethylene glycol 4000 0.4 Xanthan gum 0.5 Sodium carboxymethylcellulose*4 1 Sodium hydroxide 0.1 Methylparaben 0.2 Fragrance composition A 1.5 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated. *4 Carboxymethylcellulose sodium: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0142] Formulation Example 21: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 1.5 Polishable silica*1 12 Thickening silica*2 2 Titanium dioxide 0.4 Aluminum oxide 0.5 Sodium saccharin 0.1 Xylitol 8 Sodium fluoride 0.32 Sodium lauryl sulfate 1.4 70% sorbitol solution 32 Propylene glycol 3 Xanthan gum 0.55 Sodium polyacrylate 0.55 Methylparaben 0.1 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0143] Formulation Example 22: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.3 Polishable silica*1 15 Thickening silica*2 4.5 Aluminum oxide 0.5 Sodium saccharin 0.18 Sucralose 0.1 Sodium fluoride 0.32 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.7 Xanthan gum 0.5 Sodium polyacrylate 1.5 70% sorbitol solution 35 Propylene glycol 4 Methylparaben 0.18 Fragrance composition A 1.4 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0144] Formulation Example 23: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.5 Coconut oil fatty acid amidopropyl betaine solution*3 0.8 Polishable silica*1 17 Thickening silica*2 3.5 Titanium dioxide 0.5 Sodium saccharin 0.18 Xylitol 0.8 Sodium fluoride 0.32 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.2 Sodium alginate 0.2 Xanthan gum 1.6 Sodium polyacrylate 0.3 70% sorbitol solution 40 Propylene glycol 4 Methylparaben 0.18 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0145] Formulation Example 24: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 2.5 Thickening silica*1 5 Sodium saccharin 0.05 Tocopherol acetate 1 Sodium fluoride 0.32 Tranexamic acid 0.05 Isopropylmethylphenol 0.1 Dipotassium glycyrrhizinate 0.15 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.8 70% sorbitol solution 55 Propylene glycol 5 Polyethylene glycol 4000 1 Sodium alginate 0.6 Xanthan gum 0.9 Sodium polyacrylate 0.5 Anhydrous sodium sulfate 0.5 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0146] Formulation Example 25: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 1.5 Polishable silica*1 10 Thickening silica*2 5 Titanium dioxide 0.4 Sodium saccharin 0.16 Tocopherol acetate 0.5 Sodium fluoride 0.32 Tranexamic acid 0.05 Isopropylmethylphenol 0.07 Dipotassium glycyrrhizinate 0.12 Sodium lauroyl sarcosinate 0.2 Sodium lauroyl methyl taurate 0.5 Sodium lauryl sulfate 0.5 70% sorbitol solution 5 Propylene glycol 3 Polyethylene glycol 4000 2 Sodium alginate 0.2 Xanthan gum 1 Sodium polyacrylate 0.5 Methylparaben 0.2 Fragrance composition A 0.9 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0147] Formulation Example 26: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 2 Polyoxyethylene (5) stearyl ether 2 Thickening silica*1 1.5 Thickening silica*2 1.5 Polishable silica*3 10 Sodium saccharin 0.03 Tocopherol acetate 0.1 Sodium fluoride 0.32 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Sodium lauroyl sarcosinate 0.2 Sodium lauroyl methyl taurate 0.4 70% sorbitol solution 45 Propylene glycol 5 Polyethylene glycol 4000 3 Sodium alginate 0.6 Xanthan gum 1.2 Sodium polyacrylate 0.3 Hydroxyethylcellulose Dimethyldiallylammonium chloride 0.05 Sodium pyrrolidonecarboxylate 6 Citric acid 0.2 Sodium citrate 0.4 Fragrance composition A 1.8 Water balance Total 100 *1 Thickening silica: DSL Japan Co., Ltd. "Carplex #67Q (liquid absorption capacity 2.3)" *2 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd. *3 Abrasive silica: EVONIK Co., Ltd. Zeodent 124

[0148] Formulation Example 27: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 0.5 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 0.4 Sodium saccharin 0.06 Tocopherol acetate 0.15 Sodium fluoride 0.32 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Dipotassium glycyrrhizinate 0.035 Sodium chloride 8 Potassium nitrate 5 Sodium polyphosphate 0.5 Allantoin 0.1 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.5 70% sorbitol solution 30 Propylene glycol 3 Polyethylene glycol 400 1 Xanthan gum 2 Sodium polyacrylate 0.5 Sodium citrate 0.5 Methylparaben 0.18 Sodium hydroxide (48% solution) 0.2 Fragrance composition A 1.6 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd.

[0149] Formulation Example 28: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1.25 Polyoxyethylene(5) stearyl ether 1.25 Thickening silica*1 3 Thickening silica*2 3 Sodium saccharin 0.08 Tocopherol acetate 0.1 Sodium fluoride 0.32 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.2 70% sorbitol solution 55 Propylene glycol 3 Polyethylene glycol 4000 1 Xanthan gum 1.5 Sodium alginate 0.3 Anhydrous sodium sulfate 2 Isostearic acid 0.2 Methylparaben 0.2 Fragrance composition A 1.2 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd.

[0150] Formulation Example 29: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1 Coconut oil fatty acid amidopropyl betaine*3 0.5 Polishable silica*1 10 Thickening silica*2 5 Titanium dioxide 0.3 Sodium saccharin 0.18 Xylitol 0.01 Sucralose 0.01 Mannitol 0.01 Tocopherol acetate 0.1 Sodium fluoride 0.32 Isopropylmethylphenol 0.05 Allantoin 0.1 Tranexamic acid 0.05 Hinokitiol 0.1 Sodium lauroyl methyl taurate 0.6 Sodium lauryl sulfate 0.2 85% Glycerin 50 Propylene glycol 3 Polyethylene glycol 4000 0.3 Propylene glycol alginate 0.1 Sodium alginate 0.8 Xanthan gum 1 Citric acid 0.6 Sodium citrate 0.6 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0151] Formulation Example 30: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1.25 Polyoxyethylene (5) stearyl ether 1.25 Polishable silica*1 10 Thickening silica*2 5 Titanium dioxide 0.4 Sodium saccharin 0.16 Tocopherol acetate 0.1 Sodium fluoride 0.32 Isopropylmethylphenol 0.05 Sodium polyphosphate 1 Tranexamic acid 0.05 Sodium lauroyl methyl taurate 1.2 70% sorbitol solution 48 Propylene glycol 3 Polyethylene glycol 4000 0.1 Propylene glycol alginate 0.5 Sodium carboxymethylcellulose*3 1.2 Sodium polyacrylate 0.5 Phytosteryl isostearate 0.1 Isostearic acid 0.1 Fragrance composition A 1.3 Methylparaben 0.18 Anhydrous sodium sulfate 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0152] Formulation Example 31: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.25 Polyoxyethylene(5) stearyl ether 0.25 Coconut oil fatty acid amidopropyl betaine*3 0.3 Polishable silica*1 10 Thickening silica*2 6 Titanium dioxide 0.5 Sodium saccharin 0.18 Tocopherol acetate 0.1 Sodium fluoride 0.32 Potassium nitrate 5 Tranexamic acid 0.2 Allantoin 0.2 Isopropylmethylphenol 0.2 Sodium lauroyl methyl taurate 1.5 70% sorbitol solution 45 Propylene glycol 4 Polyethylene glycol 4000 0.5 Propylene glycol alginate 0.1 Sodium alginate 0.6 Xanthan gum 1.2 Citric acid 0.25 Sodium citrate 0.5 Phytosteryl isostearate 0.3 Isostearic acid 0.3 Fragrance composition A 1.3 Methylparaben 0.18 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0153] Formulation Example 32: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 1.5 Coconut oil fatty acid amidopropyl betaine*3 0.6 Polishable silica*1 10 Thickening silica*2 5 Sodium saccharin 0.2 Tocopherol acetate 0.1 Sodium fluoride 0.32 Tranexamic acid 0.05 Potassium nitrate 5 Isopropylmethylphenol 0.05 Sodium polyphosphate 1 Sodium azulene sulfonate 0.01 Sodium lauroyl methyl taurate 0.2 70% sorbitol solution 20 85% Glycerin 20 Propylene glycol 4 Polyethylene glycol 4000 0.4 Propylene glycol alginate 0.1 Xanthan gum 1.6 Sodium alginate 0.6 Titanium mica 0.7 Red No. 106 0.000025 Yellow No. 4 0.00025 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0154] Formulation Example 33: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 2.5 Coconut oil fatty acid amidopropyl betaine*3 0.1 Polishable silica*1 10 Thickening silica*2 1 Aluminum oxide 0.1 Sodium saccharin 0.15 Xylitol 2 Sucralose 0.003 Tocopherol acetate 0.1 Sodium monofluorophosphate 1.1 Phellodendron bark extract 0.05 Isopropylmethylphenol 0.1 Tranexamic acid 0.05 Sodium chloride 5 Hinokitiol 0.05 Sodium lauroyl sarcosinate 0.2 Sodium lauryl sulfate 1.5 70% sorbitol solution 45 Propylene glycol 4 Polyethylene glycol 400 1 Polyethylene glycol 4000 0.4 Xanthan gum 0.3 Carrageenan 0.9 Sodium alginate 0.9 Aluminum potassium sulfate 1 Sodium hydroxide 0.1 Fragrance composition A 0.7 Water balance Total 100 *1 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *2 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd. *3 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0155] Formulation Example 34: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1 Polyoxyethylene(5) stearyl ether 1.0 Decaglycerin fatty acid ester 0.1 Coconut oil fatty acid amidopropyl betaine solution*4 2 Polishable silica*2 20 Thickening silica*3 3 Titanium dioxide 0.5 Sodium saccharin 0.2 Tocopherol acetate 0.1 Sodium fluoride 0.32 Dextranase*1 0.2 (Enzyme activity per gram of preparation: 20 U) Sodium tripolyphosphate 2 Benzalkonium chloride 0.01 Sodium lauryl sulfate 0.3 N-lauroyl-L-sodium glutamate 1 70% sorbitol solution 35 Propylene glycol 3 Polyethylene glycol 4000 1 Xanthan gum 0.5 Sodium polyacrylate 0.5 Carrageenan 0.3 DL-Alanine 0.2 Fragrance composition A 1.2 Water balance Total 100 *1 Dextranase: Dextranase 2F (enzyme activity 4000 U / g) manufactured by Mitsubishi Chemical Corporation. *2 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *3 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *4 Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0156] Formulation Example 35: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.5 Polyoxyethylene (5) stearyl ether 0.5 Polishable silica*1 18 Thickening silica*2 3 Sodium saccharin 0.15 Sucralose 0.01 Sodium fluoride 0.32 Sodium lauryl sulfate 1.2 N-lauroyl-L-glutamate sodium 0.3 70% sorbitol solution 35 Propylene glycol 3 Sodium alginate 1 Fragrance composition A 1.3 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0157] Formulation Example 36: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 0.5 Heavy calcium carbonate 20 Granular zeolite (average particle size 282 μm) *1 5 Thickening silica*2 5 Aluminum Oxide 1 Sodium saccharin 0.17 Sodium fluoride 0.32 Sodium lauryl sulfate 1 70% sorbitol solution 30 Propylene glycol 2 Sodium carboxymethylcellulose*3 1.5 Methylparaben 0.2 Fragrance composition A 1 Water balance Total 100 *1 Granular zeolite: Zeolite; 80%, Anhydrous silicic acid; 18.89%, Titanium dioxide; 0.1%, Blue No. 201; 0.01% *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0158] Formulation Example 37: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (20) hydrogenated castor oil 1.2 Polishable silica*1 25 Silica granules (average particle size 250 μm) *2 3 Silica granules (average particle size 100 μm) * 3 2 Sodium saccharin 0.1 Sodium fluoride 0.32 Sodium lauryl sulfate 1.5 70% sorbitol solution 40 Propylene glycol 3 Sodium carboxymethylcellulose*4 1.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Silica granules: SORBOSIL BFG50 *3 Silica granules: SORBOSIL BFG10 *4 Carboxymethylcellulose sodium: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0159] Formulation Example 38: Toothpaste Composition Pyridoxine hydrochloride 0.02 Alkyl glucoside 1 Polyoxyethylene (10) cetyl ether 1 Polishable silica*1 15 Thickening silica*2 3 Sodium saccharin 0.2 Sucralose 0.001 Tocopherol acetate 0.2 Sodium fluoride 0.32 Dipotassium glycyrrhizinate 0.1 Isopropylmethylphenol 0.05 Cetylpyridinium chloride 0.05 70% sorbitol solution 40 Propylene glycol 0.5 Sodium carboxymethylcellulose*3 1 Sodium polyacrylate 0.2 Propylene glycol alginate 0.1 Sodium pyrrolidonecarboxylate 3 Fragrance composition A 1.2 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd. *3 Sodium carboxymethylcellulose: "CMC1260" manufactured by Daicel Mirise Co., Ltd.

[0160] Formulation Example 39: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 2 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 0.05 Sodium saccharin 0.2 Tocopherol acetate 0.5 Stannous fluoride 0.6 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium Lauroyl Methyl Taurate 1 Sodium tetradecenesulfonate 0.5 70% sorbitol solution 40 Propylene glycol 3 Polyethylene glycol 4000 0.2 Xanthan gum 1.2 Sodium alginate 0.4 Propylene glycol alginate 0.1 Titanium mica 0.3 Citric acid 0.8 Sodium citrate 0.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0161] Formulation Example 40: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 2 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 0.05 Zinc oxide 0.3 Sodium saccharin 0.2 Tocopherol acetate 0.5 Stannous fluoride 0.4 Sodium fluoride 0.11 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium Lauroyl Methyl Taurate 1 Sodium tetradecenesulfonate 0.5 70% sorbitol solution 40 Propylene glycol 3 Polyethylene glycol 4000 0.2 Xanthan gum 1.2 Sodium alginate 0.4 Propylene glycol alginate 0.1 Titanium mica 0.3 Citric acid 0.8 Sodium citrate 0.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0162] Formulation Example 41: Toothpaste Composition Pyridoxine hydrochloride 0.02 Polyoxyethylene (5) hydrogenated castor oil 2 Polishable silica*1 10 Thickening silica*2 3 Titanium dioxide 0.05 Zirconium oxide 0.5 Sodium saccharin 0.2 Tocopherol acetate 0.5 Stannous fluoride 0.4 Sodium monofluorophosphate 0.38 Tranexamic acid 0.05 Isopropylmethylphenol 0.05 Sodium Lauroyl Methyl Taurate 1 Sodium tetradecenesulfonate 0.5 70% sorbitol solution 40 Propylene glycol 3 Polyethylene glycol 4000 0.2 Xanthan gum 1.2 Sodium alginate 0.4 Propylene glycol alginate 0.1 Titanium mica 0.3 Citric acid 0.8 Sodium citrate 0.5 Fragrance composition A 1 Water balance Total 100 *1 Abrasive silica: Zeodent 124 manufactured by EVONIK Corporation *2 Thickening silica: "Carplex #67Q (liquid absorption capacity 2.3)" manufactured by DSL Japan Co., Ltd.

[0163] Formulation Example 42: Toothpaste Composition Pyridoxine hydrochloride 0.02 Sorbitan monostearate 1 POE(20) Sorbitan Monostearate 1.5 Sucrose fatty acid ester 2 Thickening silica*1 3 Tocopherol acetate 2 Sodium fluoride 0.32 Glycyrrhetinic acid 0.3 Cetylpyridinium chloride 0.05 Sodium lauryl sulfate 1.6 Hydroxyethylcellulose*2 1.5 Hydroxypropyl methylcellulose*3 1 Carboxyvinyl polymer 2.1 Polyvinylpyrrolidone 1 70% sorbitol solution 20 Propylene glycol 5 Ethanol 1 Light liquid paraffin 2 Cetanol 1.4 Fragrance composition A 1.5 Water balance Total 100 *1 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd. *2 Hydroxyethylcellulose: "HEC Daicel EE-820" manufactured by Daicel Mirise Co., Ltd. *3 Hydroxypropyl methylcellulose: "METOLOSE Hypromellose 90SH-4000SR" manufactured by Shin-Etsu Chemical Co., Ltd.

[0164] Formulation Example 43: Toothpaste Composition Pyridoxine hydrochloride 0.02 Sorbitan monostearate 0.1 POE(20) Sorbitan Monostearate 0.15 Sucrose fatty acid ester 0.5 Thickening silica*1 3 Tocopherol acetate 1.5 Sodium fluoride 0.32 Dipotassium glycyrrhizinate 0.4 Cetylpyridinium chloride 0.05 Hinokitiol 0.1 Allantoin 0.3 Sodium lauryl sulfate 1.1 Hydroxypropyl methylcellulose*2 0.3 Carboxyvinyl polymer*3 2.1 Polyvinylpyrrolidone*4 1 Sodium alginate*5 0.3 70% sorbitol solution 25 Propylene glycol 7 Ethanol 3 Light liquid paraffin 0.5 Fragrance composition A 1 Water balance Total 100 *1 Thickening silica: "Aerosil 200 (liquid absorption capacity 4.2)" manufactured by Nippon Aerosil Co., Ltd. *2 Hydroxypropyl methylcellulose: "METOLOSE Hypromellose 90SH-4000SR" manufactured by Shin-Etsu Chemical Co., Ltd. *3 Carboxyvinyl polymer: Lublizol's "Carbopol980NF" *4 Polyvinylpyrrolidone: "PLASDONE K-90" manufactured by ISP Corporation *5 Sodium alginate: "Kimika Algin ULV-20" manufactured by Kimika Co., Ltd.

[0165] Furthermore, in Examples 1 to 45 and Formulation Examples 1 to 43, toothpaste compositions with the same composition as above were prepared and evaluated, except that fragrance compositions B to S were used instead of fragrance composition A. The evaluation results were unchanged.

Claims

1. (A) Components: Pyridoxine or a salt thereof, (B) Component: Contains one or more nonionic surfactants selected from the group consisting of polyoxyethylene hydrogenated castor oil having an average number of ethylene oxide added moles of less than 60, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, alkyl glycoside, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, sugar alcohol fatty acid ester, alkylolamide, fatty acid ethanolamide, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block copolymer, and polyoxyethylene polyoxypropylene fatty acid ester, (A) A toothpaste composition having an ingredient content of 0.01% by mass or more and less than 0.2% by mass.

2. The toothpaste composition according to claim 1, wherein the content of component (B) is 0.01% to 5% by mass.

3. (C) Component: The toothpaste composition according to claim 1 or 2, further comprising an amphoteric surfactant.

4. (D) Component: The toothpaste composition according to claim 1 or 2, further comprising an inorganic powder.

5. (E) The toothpaste composition according to claim 1 or 2, further comprising one or more selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol.

6. (F) Component: The toothpaste composition according to claim 1 or 2, further comprising one or more selected from the group consisting of tocopherol acetate and tocopherol nicotinate.

7. The toothpaste composition according to claim 2, wherein the ratio of the content of component (A) to the content of component (B) ((A) / (B)) is 0.002 to 1.5.

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