Body cooling devices and containers for body cooling devices

Abstract

The present invention provides a body cooling device that can efficiently lower the core body temperature without overcooling the skin surface it comes into contact with. [Solution] The above problem is solved by a body cooling device that contains a container with a refrigerant and a carbon dioxide release source enclosed inside, which is used by contacting the skin in such a way that the released carbon dioxide permeates the body, and which is provided with a control member in the skin contact surface region which is the region that comes into contact with the skin when applied, the control member being made of thermoplastic polyurethane elastomer or silicone rubber and further comprising a carbon dioxide release amount control member that controls the amount of carbon dioxide released from the inside, and a temperature control member that controls the surface temperature of the surface that comes into contact with the skin.

Description

[Technical Field]

[0001] The present invention relates to a body cooling device and its container, which encloses a contents including a refrigerant and a carbon dioxide release source. [Background technology]

[0002] Due to the effects of recent heat waves, the importance of cooling the body in hot conditions has increased. In particular, when exercising in hot and humid environments, the body's core temperature (core body temperature) tends to rise easily because sweat does not evaporate easily, which can lead to decreased athletic performance and symptoms of heatstroke. Furthermore, if the core body temperature reaches 40°C, it is highly likely that exercise will become difficult, so cooling the body during exercise (especially suppressing excessive rises in core body temperature) is extremely important. Several body cooling devices for cooling various parts of the body in hot conditions have been developed and are available for sale.

[0003] For example, Patent Document 1 discloses a neck cooling device that is wrapped around the neck of a living person, comprising a phase change member that absorbs heat and changes from a solid phase to a liquid phase, and an outer casing that houses the phase change member, wherein the outer casing has a curved arch portion and a first free end and a second free end extending from both ends of the arch portion, and the first free end and the second free end are maintained in a state of intersecting each other without being fixed to each other, regardless of whether the phase change member is in a solid or liquid phase, by the rigidity of the outer casing. [Prior art documents] [Patent Documents]

[0004] [Patent Document 1] Japanese Patent Publication No. 2022-153086 [Overview of the Initiative] [Problems that the invention aims to solve]

[0005] Here, as mentioned above, during exercise in hot conditions, it is extremely important not only to cool the body surface but also to efficiently lower the core body temperature to prevent excessive rise. However, with body cooling devices such as those described in Patent Document 1, it is usually difficult to lower the core body temperature using the method of use that utilizes the heat of fusion of the contents. Furthermore, if the body cooling device is cooled in a freezer or similar to enhance the cooling effect and then brought into contact with the skin, vasoconstriction is likely to occur near the skin due to the effect of the low temperature, impairing blood circulation, which is important for regulating core body temperature, and thus the core body temperature may not be lowered efficiently. In addition, in this case, not only is the vasoconstriction mentioned above more likely to occur, but local pain may be felt near the skin, causing discomfort. Therefore, during exercise in hot conditions, a body cooling device is needed that can efficiently lower the body's core temperature without overcooling the skin surface in contact with the device.

[0006] The present invention has been made in view of the above problems, and relates to a body cooling device and its container (container for a body cooling device) that can efficiently lower the core body temperature without overcooling the skin surface to which it is in contact. [Means for solving the problem]

[0007] The present invention relates to a body cooling device that encloses a refrigerant and a container containing a carbon dioxide gas emission source, and is used by contacting the skin so that the emitted carbon dioxide gas penetrates the body. The body cooling device includes a control member in a skin contact surface area, which is an area including a surface that contacts the skin during application. The control member is composed of a thermoplastic polyurethane elastomer or silicone rubber, and includes a carbon dioxide gas emission amount control member that controls the amount of carbon dioxide gas emitted from the inside, and a temperature control member that controls the surface temperature of the surface that contacts the skin. The present invention also relates to a container for a body cooling device that encloses a container containing a refrigerant and a carbon dioxide gas emission source, and is used by contacting the skin so that the emitted carbon dioxide gas penetrates the body. The container includes a storage area capable of storing and sealing the container, and a control member in a skin contact surface area, which is an area including a surface that contacts the skin during application. The control member is composed of a thermoplastic polyurethane elastomer or silicone rubber, and includes a carbon dioxide gas emission amount control member that controls the amount of carbon dioxide gas emitted from the inside, and a temperature control member that controls the surface temperature of the surface that contacts the skin.

Advantages of the Invention

[0008] According to the present invention, it is possible to provide a body cooling device capable of efficiently reducing the deep body temperature without excessively cooling the skin surface to be contacted.

Brief Description of the Drawings

[0009] [Figure 1] It is a front view of an example of the body cooling device according to the present embodiment. [Figure 2] It is a schematic diagram of an example of using the body cooling device of FIG. 1 by contacting the skin of the neck. [Figure 3] It is a schematic cross-sectional view of a specific example ((a), (b), or (c)) of the control member of the container for the body cooling device according to the present embodiment. [Figure 4]This graph shows the change in core body temperature when the body cooling device of Example 1 was applied. Note that "Application time 10 minutes" in the figure means that the body cooling device was applied for 10 minutes, i.e., removed from the body 10 minutes after application began. The same applies to Figures 5-11 below. [Figure 5] This graph shows the change in core body temperature when the body cooling device of Comparative Example 1 is applied. [Figure 6] This graph shows the temperature comfort when the body cooling device of Example 1 is applied. [Figure 7] This graph shows the temperature comfort when the body cooling device of Comparative Example 1 is applied. [Figure 8] This graph shows the skin surface temperature of the area where the body cooling device of Example 1 was applied. [Figure 9] This graph shows the skin surface temperature of the area where the body cooling device of Comparative Example 1 was applied. [Figure 10] This graph shows the temperature sensation at the application site when the body cooling device of Example 1 is applied. [Figure 11] This graph shows the temperature sensation at the application site when the body cooling device of Comparative Example 1 is applied. [Modes for carrying out the invention]

[0010] Preferred embodiments of the present invention will be described below with reference to the drawings. In all drawings, similar components are denoted by the same reference numerals, and redundant explanations are omitted as appropriate. In addition, for convenience, some parts of the drawings do not have reference numerals (they are omitted). Furthermore, the dimensional ratios of each component shown in the drawings may differ from the actual dimensional ratios in order to facilitate understanding of the invention.

[0011] [Configuration of the body cooling device and its container according to this embodiment] The configuration of the body cooling device 100 and its container 101 (body cooling device container 101) according to this embodiment will be explained using Figures 1 to 3 and other references. Figure 1 is a schematic diagram showing an example of a body cooling device 100 according to this embodiment, obtained by sealing carbon dioxide-containing cold water as a contents in the main body portion 31 (container area 41) of the body cooling device container 101 according to this embodiment. Figure 2 is a schematic diagram showing an example of using the body cooling device 100 according to this embodiment shown in Figure 1 in contact with the skin of the neck. Furthermore, Figure 3 is a schematic cross-sectional diagram showing specific configuration examples (a) to (c) of the control member 10 in the main body portion 31 (its skin contact surface area 51) of the body cooling device container 101 according to this embodiment.

[0012] The body cooling device 100 according to this embodiment contains a container (enclosed in a containment area 41) that includes a refrigerant and a carbon dioxide release source, and is used by allowing the carbon dioxide released from the internal container to the outside of the container to permeate the body and come into contact with the skin. The body cooling device 100 is equipped with a control member 10 in the skin contact area 51, which is the area that comes into contact with the skin when applied. The control member 10 is made of thermoplastic polyurethane elastomer or silicone rubber and includes a carbon dioxide release amount control member 11 that controls the amount of carbon dioxide released from the internal container, and a temperature control member 13 that controls the surface temperature of the surface that comes into contact with the skin. Furthermore, the body cooling device container 101 according to this embodiment, used in the body cooling device 100, comprises a containment area 41 capable of containing and sealing (enclosing) the above-mentioned contents, and a control member 10 in a skin contact surface area 51 which includes a surface that comes into contact with the skin when applied. The control member 10 is made of thermoplastic polyurethane elastomer or silicone rubber and includes the carbon dioxide release amount control member 11 and temperature control member 13 described above. Here, "used in contact with the skin" in this embodiment includes not only embodiments in which the body cooling device 100 is used in direct contact with the skin, but also embodiments in which it is used indirectly through clothing or a patch between the body cooling device and the skin (indirect contact within the range in which the predetermined cooling and carbon dioxide penetration functions described above can be performed). However, embodiments in which the body cooling device 100 is used in direct contact with the skin are more preferable.

[0013] For example, as shown in Figures 1 and 2, a body cooling device 100 is shown, which is a body cooling device container 101 in which a contents containing a refrigerant and a carbon dioxide release source is injected into the contents of

[0014] Furthermore, the application area of ​​the body cooling device 100 according to this embodiment is not limited to the skin of the neck or feet, but can be applied to the skin of any part of the body as long as it can perform the predetermined cooling and carbon dioxide penetration functions described above. For example, it can be used in contact with the skin of the arms, armpits, waist, face, etc. Furthermore, the shape of the body cooling device 100 (body cooling device container 101) according to this embodiment is not limited to the shapes shown in Figures 1 and 2, but can be any shape that can be used in contact with the skin of the body. For example, it may be a flexible pillow shape, cylindrical shape, ring shape, ice pack shape, or other bag shape. Also, the film or sheet forming the main body portion 31 of the body cooling device 100 may be a single-layer film or single-layer sheet, or a laminated film or laminated sheet, or a multi-layer structure in which single-layer or laminated films are superimposed in two or more layers in a non-jointed contact state (for example, a double-layer structure in which a single-layer outer container 203 is superimposed so as to enclose a single-layer inner container 201 forming a containment area 41, as shown in Figure 3(c)). In this double-walled embodiment, it is preferable that the inner container 201 and the outer container 203 are in substantially contact with each other. However, a gap may be included in the skin contact area 51 or other areas between the inner container 201 and the outer container 203, as long as the predetermined cooling and carbon dioxide penetration functions described above are achieved. The same applies to other multi-layered embodiments.

[0015] The following describes in detail the various components of the body cooling device 100 and the body cooling device container 101 according to this embodiment.

[0016] <Containment Area> As described above, the body cooling device 100 according to this embodiment contains a container that includes a refrigerant and a carbon dioxide release source. Therefore, the body cooling device container 101 used according to this embodiment is provided with a containment area 41 in its main body 31 or the like, which is an internal space that can contain (contain and seal) the above-mentioned container. For example, it may be a bag-shaped container that has a containment area 41. The above-mentioned container is then contained within this containment area 41 to form the body cooling device 100. Here, "containment" means containing and sealing the container within the containment area 41 as described above, but in this case, as will be described later, carbon dioxide can permeate to a certain extent through the film or sheet that forms the containment area 41. However, it is preferable that the film or sheet that forms this containment area 41 is impermeable as a whole so that carbon dioxide-containing cold water can be contained within it. Here, impermeable means that liquid substances such as water do not permeate substantially.

[0017] The shape of the containment area 41 is not particularly limited, as long as it can be used in a way that it comes into contact with at least a part of the body's skin and allows carbon dioxide gas released from inside (i.e., the contents inside the body cooling device 100) to the outside of the container (i.e., outside the body cooling device 100) to permeate the body. For example, it can have internal shapes such as pillow-shaped, cylindrical, ring-shaped, ice pack-shaped, or other bag-shaped shapes as described above. The size of the containment area 41 is also not particularly limited, but a volume of 50 cm³ per container is recommended for easier contact with various parts of the body and for easier portability. 3 (0.05L) or more 2500cm 3 It is preferable that the volume be 2.5L or less. The lower limit is 100cm. 3 It may be (0.1L) or more, and 150cm 3 (0.15L) or more is also acceptable. The upper limit is 2200cm. 3 (2.2L) or less, and 2000cm 3 The volume may be 2.0 L or less. Then, an amount of contents that can be contained therein (for example, 150 to 2000 mL of liquid or slurry contents) is placed inside and sealed to form the body cooling device 100.

[0018] Furthermore, it is preferable that the main body 31, which includes the storage area 41, is connected to an injection port 21 that allows the contents to be injected into the storage area 41 and sealed, and that the sealed contents can be discharged. The injection port 21 is configured to be openable and closable, and to be able to seal the storage area 41 (main body 31). Therefore, as long as it has such a configuration, it is not limited to other configurations, but for example, as shown in Figure 1, the injection port 21 is equipped with a detachable cap and a cap mounting part, and male and female screw shapes (spiral grooves) are formed on the inner circumference of the cap and the outer circumference of the cap mounting part, and these can be attached, detached, and sealed by screwing them together. Furthermore, the opening may be opened and closed by sliding a cap-like component (sliding type), and the configuration may not require attachment or removal. In addition to the cap, a pinch-fastening system (a system that seals with pinches made of resin or metal) may also be used. Such configurations make repeated use easier, as described above. The connection area of ​​the inlet portion 21 is not particularly limited as long as it is not the skin contact surface area 51, but it is preferable that it be connected to an area that is less likely to come into contact with the body when the body cooling device 100 is applied.

[0019] Furthermore, the size of the inlet portion 21 is not particularly limited; for example, the opening diameter of the inlet portion 21 should be large enough to allow the contents to be injected. From the viewpoint of ease of injection and drainage of the contents (ease of injection and discharge), the opening diameter (inner diameter of the opening) of the inlet portion 21 is preferably 20 mm or more, and more preferably 24 mm or more. This upper limit may be 60 mm or less, or 55 mm or less. Furthermore, while resin and metal are shown as preferred materials for the inlet portion 21, from the viewpoint of weight reduction, it is more preferable that it be made of resin materials such as polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polystyrene (PS), nylon (Ny), acrylonitrile-butadiene-styrene copolymer (ABS), polyethylene terephthalate (PET), polylactic acid (PLA), polycarbonate (PC), epoxy resin, and urethane resin. The same applies when the aforementioned cap is provided. Furthermore, this inlet portion 21 may be made of the same material as the control member 10 (i.e., the main body portion 31) which will be described later.

[0020] <Control component> The body cooling device 100 according to this embodiment is equipped with a control member 10 in the skin contact area 51 (the area of ​​the main body 31 that comes into contact with the skin, as described above), which is the area that comes into contact with the skin when applied. In other words, the body cooling device container 101 used in this embodiment is equipped with a control member 10 in its skin contact area 51 (main body 31). The control member 10 is made of thermoplastic polyurethane elastomer or silicone rubber and includes a carbon dioxide release amount control member 11, which has the function of controlling the amount of carbon dioxide released from the inside to the outside of the container within a desired range in relation to the carbon dioxide release source of the contents, and a temperature control member 13, which has the function of controlling the surface temperature of the surface that comes into contact with the skin within a desired range in relation to the temperature of the contents, etc.

[0021] The control member 10 may have a single-layer integrated structure in which the carbon dioxide release amount control member 11 and the temperature control member 13 are integrated into a single layer, or the control member 10 (the entire control member 10) may have a single-layer integrated structure in which it is integrated into a single layer. In other words, the control member 10 itself may have both the carbon dioxide release amount control function and the temperature control function as described above. For example, the control member 10 including the carbon dioxide release amount control member 11 and the temperature control member 13, as in the embodiment of Figure 3(a), may be a single-layer film or single-layer sheet (a single-layer integrated film or sheet having both the carbon dioxide release amount control function and the temperature control function as described above). Alternatively, the control member 10 may have a laminated structure in which multiple layers including these are stacked (for example, a laminated film or laminated sheet having a laminated structure in which multiple layers including the carbon dioxide emission control member 11 and / or temperature control member 13 are stacked, as in the embodiment of Figure 3(b)), or it may have a multilayer structure in which two or more single-layer or laminated films, etc., are stacked in contact without being joined (for example, the embodiment of Figure 3(c)). However, since its thickness, carbon dioxide permeability, and thermal conductivity can be easily determined, and it is easy to control both the amount of carbon dioxide emitted from the inside and the surface temperature of the surface that comes into contact with the skin to be within a desired range, it is more preferable for the control member 10 to have a single-layer integrated structure in which the carbon dioxide emission control member 11 and the temperature control member 13 are integrated into a single layer (a single-layer film or single-layer sheet made of a predetermined material), and it is even more preferable for the entire control member 10 to have a single-layer integrated structure in which the carbon dioxide emission control member 11 and the temperature control member 13 are integrated into a single layer.

[0022] For example, if the control member 10 has the single-layer integrated structure described above, the single-layer film or single-layer sheet forming the control member 10 (i.e., the main body portion 31) of the body cooling device 100 (container 101) according to this embodiment is made of thermoplastic polyurethane elastomer or silicone rubber. In other words, the single-layer film or single-layer sheet forming the control member 10, including the carbon dioxide emission control member 11 and the temperature control member 13, is a film or sheet mainly composed of thermoplastic polyurethane elastomer or silicone rubber. A single-layer film or single-layer sheet mainly composed of thermoplastic polyurethane elastomer has a certain degree of carbon dioxide permeability even at a certain thickness and its thermal conductivity is also well known, making it easy to control the carbon dioxide emission amount and the surface temperature to the desired level. Furthermore, due to its material properties, it is easy to achieve a high degree of compatibility between conformability to the body at low temperatures and durability at low temperatures. A single-layer film or sheet containing silicone rubber as the main component has high carbon dioxide permeability, making it easy to adjust the layer thickness while maintaining a high carbon dioxide release rate, and thus making it easier to create a body cooling device 100 with superior strength. Furthermore, as described above, the control member 10 may be in the form of multiple layers or stacks of films or sheets containing thermoplastic polyurethane elastomer or silicone rubber as the main component (for example, a multi-layer or multi-layer structure of films or sheets made of thermoplastic polyurethane elastomer, or a multi-layer or multi-layer structure of films or sheets made of silicone rubber). Note that "contained as the main component" means containing 80% or more of the material by mass, more preferably 90% or more, even more preferably 95% or more, and may even be 100% (made of the material). Therefore, for example, it is also acceptable to include small amounts of known additives commonly used in films and sheets. The same applies to other parts.

[0023] Here, "thermoplastic polyurethane elastomer (TPU)" refers to a polyurethane material that combines the properties of thermoplastics with the properties of elastomers (elastic properties). This thermoplastic polyurethane elastomer may be either ether-based or ester-based, but one composed of an ether-based thermoplastic polyurethane elastomer (especially a single-layer film or single-layer sheet) is more preferable because it allows for a high degree of compatibility between conformability to the body at low temperatures and durability at low temperatures, while also making it easier to control carbon dioxide release and providing excellent water resistance. Furthermore, it tends to have excellent abrasion resistance. Note that "ether-based thermoplastic polyurethane elastomer" refers to one in which the main chain of the thermoplastic polyurethane elastomer molecule contains an ether bond (-O-), and "ester-based thermoplastic polyurethane elastomer" refers to one in which the main chain of the thermoplastic polyurethane elastomer molecule contains an ester bond (-COO-). Furthermore, "silicone rubber" refers to a rubber material that primarily contains a thermosetting polymer material (siloxane polymer material) having a polyorganosiloxane skeleton and elastomer properties (elastic properties), and may have a cross-linked structure. The phrase "primarily contains" has the same meaning as described above; therefore, in addition to high-purity silica and plasticizers used to improve the heat resistance and strength of silicone rubber, it may also contain small amounts of known additives commonly used in films and sheets. However, even in this case, the control member 10 made of silicone rubber contains at least 80% by mass of the aforementioned specified polymer material. To elaborate further on silicone rubber, as mentioned above, silicone rubber is a rubber material mainly composed of a predetermined polymer material having a polyorganosiloxane skeleton. Based on differences in curing mechanisms, it is broadly classified into high-temperature curing silicone rubber (HTV) and room-temperature curing silicone rubber (RTV). When used as part of the configuration of the control member 10, for example, in the embodiment shown in Figure 3(b), a wide range of sheet-type silicone rubber can be selected. On the other hand, in order to obtain a hollow, three-dimensional structure such as the embodiment shown in Figure 3(a), since silicone rubber is thermosetting, it is necessary to mold it through a heat curing or (heat) reaction curing process. Therefore, compression molding, transfer molding, and injection molding are mainly selected as molding methods, and it is preferable to use high-temperature curing silicone rubber from the viewpoint of processability. Furthermore, high-temperature curing silicone rubber is classified into millable-type silicone rubber (silicone rubber mainly composed of linear siloxane polymer material with an average degree of polymerization of 3,000 to 10,000) and liquid silicone rubber (silicone rubber mainly composed of linear siloxane polymer material with an average degree of polymerization of 100 to 2,000). However, in order to obtain appropriate thinness, flexibility, and strength for molded products, it is preferable to use millable-type silicone rubber, which has a high degree of polymerization of the raw polymer, as the constituent material. Here, this average degree of polymerization is the weight-average degree of polymerization in polystyrene terms, measured by GPC (gel permeation chromatography) using toluene as the solvent.

[0024] Furthermore, the control member 10 (i.e., the carbon dioxide emission control member 11 and / or temperature control member 13) may be made of materials other than the thermoplastic polyurethane elastomer and silicone rubber described above, as long as they have the predetermined properties. For example, they may be made of thermoplastic polyolefin elastomer (TPO), thermoplastic polystyrene elastomer (TPS), etc. In addition, the laminated structure may consist of two or more layers made of either the thermoplastic polyurethane elastomer or silicone rubber described above, or a laminated structure in which one or more layers made of either of these materials are laminated with a layer made of another material as described later. However, as mentioned above, it is more preferable that the control member 10 be made of thermoplastic polyurethane elastomer or silicone rubber. For example, the control member 10 in the embodiment of Figure 3(a) may be made entirely of silicone rubber. And, as also mentioned above, in this embodiment, the control member 10 may be made using both thermoplastic polyurethane elastomer and silicone rubber, for example, a laminated structure of a layer made of thermoplastic polyurethane elastomer and a layer made of silicone rubber.

[0025] In addition, in cases such as the laminated structure described above, the control member 10 may contain, in addition to the main component thermoplastic polyurethane elastomer or silicone rubber, other materials as minor components or constituent materials (auxiliary materials) in a total of 20% by mass or less. For example, at least one selected from the group consisting of woven fabric, nonwoven fabric, natural rubber, synthetic rubber, synthetic resin (e.g., linear low-density polyethylene (LLDPE), etc.), foamed plastic, paper, and metal may be included in a part of the control member 10 (such as a part that does not substantially affect the carbon dioxide emission control function and the temperature control function). Specifically, the layer laminated on a portion of the outer surface (skin-contacting surface) of a film or sheet made of the thermoplastic polyurethane elastomer or silicone rubber described above may be a layer of a predetermined thickness made of woven or nonwoven fabric, a net layer of a predetermined thickness made of natural rubber, synthetic rubber, or synthetic resin, a porous film or porous sheet, a foamed plastic layer with holes, a paper layer, a metal foil with holes, or a combination of two or more selected from these, provided that it does not substantially affect the carbon dioxide emission control function and temperature control function of the film or sheet. Furthermore, layers made of the aforementioned thermoplastic polyolefin elastomer, etc., may be combined as auxiliary components or auxiliary materials, to the extent that they do not substantially affect the carbon dioxide emission control function and temperature control function.

[0026] Furthermore, the control member 10 (main body 31) may be separable into two or more components, including the carbon dioxide release amount control member 11 and the temperature control member 13. For example, as shown in Figure 3(c) above, the control member 10 (main body 31) of the skin contact surface area 51 may have a configuration in which the inner container 201 (which mainly functions as the carbon dioxide release amount control member 11 and may also function as part of the temperature control member 13) and the outer container 203 (which mainly functions as the temperature control member 13 or a part thereof) are superimposed on the inner container 201 so as to enclose it, and these are in substantially contact with each other without adhesive. More specifically, examples include embodiments in which the inner container 201 is made of the thermoplastic polyurethane elastomer or silicone rubber described above, and the outer container 203 is also made of the thermoplastic polyurethane elastomer or silicone rubber described above, or the outer container 203 is made of a nonwoven fabric or woven fabric of a predetermined thickness described above (in this case, only the inner container 201 functions as the carbon dioxide emission control member 11 and the temperature control member 13). However, as mentioned above, it is more preferable that the control member 10 is a single-layer integrated structure in which the carbon dioxide emission control member 11 and the temperature control member 13, both made of thermoplastic polyurethane elastomer or silicone rubber, are integrated into a single layer.

[0027] Furthermore, in this embodiment, the body cooling device 100, through the combination of the carbon dioxide release source of the contained object and the control member 10, has a carbon dioxide release rate (amount of carbon dioxide released from the inside to the outside, and the amount of carbon dioxide released from the inside) of 3.2 mL / m³ per minute after the contained object is sealed. 2It is more preferable that the amount continues for 5 minutes or more. That is, it is more preferable that the amount of carbon dioxide gas in the carbon dioxide gas release source of the contained substance, the constituent material of the control member 10, the thickness, etc. are adjusted so as to achieve the above carbon dioxide gas release amount. For example, when carbon dioxide gas-containing water with an initial carbon dioxide gas concentration of 1000 ppm or more is enclosed as a contained substance in the accommodation area 41 of the body cooling device container 101 according to the present embodiment (when the carbon dioxide gas concentration of the carbon dioxide gas-containing water immediately after enclosure is 1000 ppm or more), the carbon dioxide gas release amount is, for example, 3.2 mL / m per minute from immediately after enclosing this contained substance 2 It is preferable that it is controlled (adjusted) so that it can continue for 5 minutes or more. In particular, when carbon dioxide gas-containing water with an initial carbon dioxide gas concentration of 1000 ppm is enclosed as a contained substance in the accommodation area 41 of the body cooling device container 101 according to the present embodiment, it is more preferable that the carbon dioxide gas release amount is controlled as described above. This is because a large amount of carbon dioxide gas can penetrate the body at the initial stage of application of the body cooling device 100 according to the present embodiment, and vasoconstriction can be quickly prevented. As a result, it becomes easier to increase the rate of decrease in deep body temperature. When the type of the contained substance to be enclosed, the carbon dioxide gas release source, etc. are changed, the thickness and the type of the constituent material of the control member 10 (particularly the member that exhibits the function as the carbon dioxide gas release amount control member 11) may be adjusted so as to achieve the above carbon dioxide gas release amount. Incidentally, the carbon dioxide gas release amount (the amount that continues for 5 minutes or more) per minute after enclosing this contained substance is 4.0 mL / m 2 It is more preferable that it is 4.5 mL / m 2 It is even more preferable that it is 4.9 mL / m 2 It is even more preferable that it is 5.5 mL / m 2 It is even more preferable that it is 6.0 mL / m 2 It is even more preferable that it is 6.5 mL / m 2 It is even more preferable that it is 100 mL / m or less from the viewpoint of the persistence of carbon dioxide gas release 2 It is more preferable that it is 80 mL / m or less 2It is even more preferable that the following is true: 70 mL / m² 2 The following is even more preferable. Furthermore, the duration is preferably 6 minutes or more, more preferably 8 minutes or more, and even more preferably 10 minutes or more. In other words, it is more preferable that these are controlled within the above range. And since this embodiment is made of the aforementioned thermoplastic polyurethane elastomer or silicone rubber having high carbon dioxide permeability, this can be easily achieved by fine-tuning the thickness of the control member 10 and the configuration of the carbon dioxide release source of the contents (such as carbon dioxide concentration).

[0028] Furthermore, the body cooling device 100 according to this embodiment, through the combination of the carbon dioxide release source and control member 10 of the contained object, releases a total amount of carbon dioxide of 30 mL / m³ from the time the contained object is sealed until 10 minutes have elapsed. 2 It is more preferable that the amount is greater than or equal to the above. In other words, it is more preferable that the amount of carbon dioxide in the carbon dioxide release source of the containment and the constituent material and thickness of the control member 10 are adjusted so that the total amount of carbon dioxide released is as described above. For example, when carbon dioxide-containing water with an initial carbon dioxide concentration of 1000 ppm or more is sealed as the containment in the containment area 41 of the body cooling device container 101 according to this embodiment (when the carbon dioxide concentration of the carbon dioxide-containing water immediately after sealing is 1000 ppm or more), the total amount of carbon dioxide released from immediately after sealing the containment to 10 minutes later is 30 mL / m³, depending on the combination of the carbon dioxide in the containment and the control member 10 of a predetermined thickness made of a predetermined material. 2It is preferable that the system is controlled (adjusted) to achieve the above. In particular, it is even more preferable that the total amount of carbon dioxide released is controlled to be the above when carbon dioxide-containing water with an initial carbon dioxide concentration of 1000 ppm is sealed as the contents in the containment area 41 of the body cooling device container 101 according to this embodiment. This is because a sufficient amount of carbon dioxide can be permeated into the body by applying the body cooling device 100 according to this embodiment for a certain period of time, and the persistence of this effect makes it easier to sufficiently lower the core body temperature. If the contents to be sealed or the type of carbon dioxide release source are changed, the thickness of the control member 10 (especially the member that functions as a carbon dioxide release amount control member 11) and the type of constituent material can be adjusted accordingly to achieve the above total amount of carbon dioxide released. Furthermore, the total amount of carbon dioxide released from the contents up to 10 minutes after sealing was 40 mL / m³. 2 Preferably, it is 49 mL / m² 2 It is more preferable that the value is greater than or equal to 60 mL / m². 2 It is even more preferable if it is 70 mL / m² 2 It is more preferable to be 90 mL / m² or more. 2 It is even more preferable if it is greater than or equal to this. This upper limit is 1000 mL / m³, also from the viewpoint of the sustainability of carbon dioxide release. 2 Preferably, it is 500 mL / m² 2 It is more preferably the following: 450 mL / m² 2 It is even more preferable that the following conditions are met: 400 mL / m² 2 It is even more preferable that the following conditions are met: 350 mL / m² 2 The following is even more preferable. In other words, it is more preferable that these are controlled within the range described above. And this is also easily achievable by fine-tuning the thickness of the control member 10 and the configuration of the carbon dioxide release source of the contents (such as carbon dioxide concentration), since the control member 10 is made of the aforementioned thermoplastic polyurethane elastomer or silicone rubber having high carbon dioxide permeability.

[0029] In addition, the above describes the amount of carbon dioxide released per minute from immediately after sealing the contents (initial period) and the cumulative amount released up to 10 minutes later (total amount of carbon dioxide released). However, in order for the body cooling device 100 according to this embodiment to exert an immediate effect of lowering core body temperature, it is more preferable that the amount of carbon dioxide released per minute from immediately after sealing the contents be high. This can be confirmed by the fact that the curve (carbon dioxide release curve) that shows the change in the amount of carbon dioxide released over time, measured by the following method, is convex upwards.

[0030] Here, the carbon dioxide emission amount and total carbon dioxide emission amount mentioned above are values ​​measured by the following method. 1) A test piece measuring 70 mm in width and 70 mm in length is sampled from a control member 10 of a predetermined thickness in the body cooling device 100 (body cooling device container 101) according to this embodiment. If the control member 10 includes two or more members, the test piece is sampled so as to include the entire total thickness of the control member 10. 2) Prepare a set of two commercially available 450ml UM glass bottles, and pre-purge one of them, UM glass bottle (A), with nitrogen gas. Place the test specimen over the opening of (A) after nitrogen gas purging, ensuring it is smooth and free of gaps or wrinkles, and securely fasten the edges of the opening with tape. Do not stretch the test specimen at this time. Then, fill the other UM glass bottle (B), which has been nitrogen-purged, with carbon dioxide-containing water at 25℃±1℃ with a predetermined carbon dioxide concentration (for example, 1000ppm) to the brim of the bottle opening. Immediately overlap the opening of (A) onto the opening of (B) without any gaps (so that there are no air gaps between the liquid surface and the film or sheet), and wrap the surrounding area with plastic wrap. The room temperature during this preparation should be 25℃±1℃. 3) After 1 minute, remove (A) from (B), remove the test piece attached to the opening, and immediately seal the opening of (A) with plastic wrap. Then, using a carbon dioxide concentration measuring device (GASTEC, gas detection tube "2LC" (carbon dioxide detection tube: 100-2000 ppm when 100 ml is drawn, 200-4000 ppm when 50 ml is drawn)), measure the carbon dioxide concentration inside (A) 2 minutes after sealing the opening with plastic wrap. A GASTEC gas sampler "GV-100S" will be used for the measurement, and the measurement will be performed according to the operating instructions for the gas detection tube and gas sampler. The measurement environment will be an atmospheric environment of 25℃±1℃ and 70% relative humidity. 4) Perform the same measurement three times, and use the average of the three measurements (average amount of detected carbon dioxide) as the "carbon dioxide emission rate per minute" mentioned above. 5) The total amount of carbon dioxide released at 5 minutes and 10 minutes is measured in the same manner as above, except for the elapsed time. The same applies to other elapsed times, such as the total amount of carbon dioxide released at 30 minutes. The continuity at 5 minutes may be calculated by drawing a carbon dioxide release curve from the amount of carbon dioxide released per minute and the total amount of carbon dioxide released at 5 minutes, or it may be calculated by individually measuring the amount of carbon dioxide released at 5 minutes (divided into 1-minute intervals).

[0031] Furthermore, it is preferable that the body cooling device 100 according to this embodiment controls the surface temperature of the surface that comes into contact with the skin by the configuration of the control member 10 (mainly the temperature control member 13), so that when the temperature of the contents is set to 1°C to 5°C, or even 1°C to 3°C, the surface temperature of the skin facing the surface that comes into contact with the skin when the body cooling device 100 is applied is 18°C ​​to 25°C. In other words, it is preferable that the constituent materials, thickness, etc. of the control member 10 are adjusted so that the surface temperature of the skin to which the body cooling device 100 is applied falls within the above range. For example, when a contents temperature of 1°C to 5°C is enclosed in the containment area 41 of the body cooling device container 101 according to this embodiment, it is preferable that the skin surface temperature is controlled (adjusted) to 18°C ​​to 25°C by a combination of the temperature of the contents and the control member 10 of a predetermined thickness made of a predetermined material. Furthermore, it is preferable that the skin surface temperature is maintained within the above range for at least 10 minutes after the body cooling device 100 is applied (more preferably between 5 minutes and 10 minutes after application). This is because when the body cooling device 100 according to this embodiment is applied, local pain is less likely to be felt, and the effect of lowering core body temperature is more easily exerted. It is even more preferable that the skin surface temperature remains between 18°C ​​and 25°C even when the temperature of the contents is outside the above range (for example, between 5°C and 10°C or between 10°C and 15°C). Furthermore, it is even more preferable that the skin surface temperature is 19°C or higher, and even more preferable that it is 23°C or lower, and even more preferable that it is 21°C or lower. Here, "the surface temperature of the skin facing the surface in contact with the skin is 18°C ​​to 25°C" means that, in an ambient temperature of 35°C (a hot environment), when the surface of the body cooling device 100 according to this embodiment, which contains the above-mentioned contents, is applied in contact with the skin, the surface temperature of the skin facing this surface becomes within the range of 18°C ​​to 25°C due to its cooling effect. The same applies to the preferred temperatures mentioned above. The surface temperature of the skin can be measured by setting up a known surface temperature measuring instrument, such as a thermistor thermometer, facing the skin surface under predetermined conditions. The measurement site for the surface temperature of the skin is not particularly limited as long as it is the contact area of ​​the body cooling device 100, but it is preferable to select a site where the body cooling device 100 is in close contact with the skin without any gaps, such as the posterior neck in Figure 2 (a skin area where the body cooling device 100 is in substantially direct contact).

[0032] As mentioned above, the amount of carbon dioxide released, the total amount of carbon dioxide released, and the surface temperature (such as the surface temperature of the surface that comes into contact with the skin) can all be adjusted by a combination of factors such as the type and layer configuration of the materials constituting the control member 10 of the body cooling device 100 according to this embodiment (i.e., the carbon dioxide release control member 11 and the temperature control member 13), the total thickness of the film or sheet, the type and temperature of the contents, and the amount of carbon dioxide from the carbon dioxide release source. In other words, the amount of carbon dioxide released, the total amount of carbon dioxide released, and the surface temperature can all be adjusted by these factors.

[0033] The total thickness of the film or sheet forming the control member 10 may be set appropriately, taking into account the relationship with each member, in accordance with the characteristics of the constituent materials and the composition of the contents, as described above, so as to enable control to the desired amount of carbon dioxide released and the desired surface temperature. However, as an example, the total thickness may be in the range of 50 μm to 2000 μm. The lower limit may be 80 μm or more, 100 μm or more, 150 μm or more, 200 μm or more, 250 μm or more, or 300 μm or more. The upper limit may be 1500 μm or less, 1000 μm or less, 800 μm or less, or 600 μm or less. For example, if the control member 10, including the carbon dioxide emission control member 11 and the temperature control member 13, is a film or sheet (particularly a single-layer film or single-layer sheet) made of thermoplastic polyurethane elastomer, its thickness (total thickness) is preferably 100 μm or more and 600 μm or less, more preferably 200 μm or more and 600 μm or less, and even more preferably 200 μm or more and 500 μm or less. Also, if the control member 10, including the carbon dioxide emission control member 11 and the temperature control member 13, is a film or sheet (particularly a single-layer film or single-layer sheet) made of silicone rubber, its thickness (total thickness) is preferably 100 μm or more and 2000 μm or less, more preferably 200 μm or more and 2000 μm or less, even more preferably 300 μm or more and 2000 μm or less, and even more preferably 300 μm or more and 1500 μm or less. Furthermore, the film or sheet of the entire main body 31 including the control member 10 may have the total thickness described above. Here, "total thickness" refers to the total length in the thickness direction of the film or sheet forming the control member 10, that is, the sum of the thicknesses of all the layers constituting the control member 10. Therefore, in laminated structures in which multiple layers are stacked, it is the sum of the thicknesses of all of them, including embodiments that include the inner container 201 and outer container 203 described above.

[0034] <Contents> The contents contained and enclosed in the body cooling device 100 according to this embodiment are not limited to those other than a refrigerant and a carbon dioxide release source. Examples include a refrigerant containing carbon dioxide at a temperature of 1°C to 15°C (such as carbon dioxide-containing cold water with a carbon dioxide concentration of 100 ppm or more), a refrigerant at a temperature of 1°C to 15°C in which a predetermined amount of a mixture of carbonate and an organic acid is dissolved, dry ice or a liquid containing dry ice (dry ice slurry), etc. The refrigerant (a cold liquid, slurry, or solid for heat conduction) may be water, ice water, ice, etc., and also includes dry ice, which is also a carbon dioxide release source. Furthermore, this contents may also contain additives such as sugar alcohols, surfactants, and plant extracts.

[0035] Here, the "carbon dioxide emission source" refers to the source of carbon dioxide released from the contents to the outside of the body cooling device 100 (body cooling device container 101), and includes not only the carbon dioxide dissolved in the refrigerant of the contents, but also sources that generate carbon dioxide through chemical reactions during dissolution (carbon dioxide generation sources). Specifically, this includes carbon dioxide dissolved in carbon dioxide-containing cold water, dry ice, and mixtures of carbonates and organic acids. In the case of the carbon dioxide-containing cold water mentioned above, the carbon dioxide concentration may be 200 ppm or more, 500 ppm or more, 800 ppm or more, or 1000 ppm or more. The upper limit may be, for example, 4000 ppm or less. In addition, the temperature of the refrigerant (i.e., the contents, especially the contents immediately after sealing) may be 1°C to 15°C as mentioned above, but it may also be 1°C to 10°C, 1°C to 5°C, or 1°C to 3°C.

[0036] As described above, the body cooling device 100 according to this embodiment can be used by bringing it into contact with the skin in such a way that carbon dioxide gas released to the outside from the control member 10 of the skin contact surface area 51 permeates the body, as shown in Figure 2. This allows the body to be cooled while suppressing vasoconstriction near the contact area (maintaining blood circulation to a certain extent) by the carbon dioxide gas that has permeated the body, and efficiently lowering the core body temperature without overcooling the skin surface (skin surface) that is in contact with the body. In other words, it is less likely to cause unpleasant sensations such as local pain when applied, and it can lower the core body temperature more efficiently and prevent an excessive rise in core body temperature, making it particularly suitable as a body cooling device to suppress a decline in exercise performance under hot conditions.

[0037] The following describes embodiments of the present invention, but the present invention is not limited to the following embodiments, and various modifications are possible within the technical concept of the present invention. [Examples]

[0038] (Example 1) Using a single-layer film of the constituent materials listed below, a body part with the shape shown in Figure 2 was formed by heat sealing, and a container for a body cooling device was manufactured with a predetermined control member in the skin contact area. The thickness of the film (or sheet) used was measured using a PG-11 thickness gauge manufactured by Teclock Co., Ltd., after spreading the film (or sheet) on the base without wrinkles and applying a standard load of 3.7 gf / cm². 2The measurement was performed (the same applies to the following examples, etc.). Then, 1650 mL of carbon dioxide-containing cold water with a temperature of 1°C and a carbon dioxide concentration of 1000 ppm was sealed inside this body cooling device container, and a body cooling device (with carbon dioxide release) that releases a predetermined amount of carbon dioxide to the outside of the container was manufactured. Here, the carbon dioxide concentration was measured using a carbon dioxide meter (such as the IM-32P hydrogen ion concentration indicator manufactured by Toa DKK Co., Ltd.) immediately after preparing the carbon dioxide-containing cold water prepared at a temperature of 1°C, and the value after the indicated value stabilized was taken as the initial concentration. In other words, carbon dioxide-containing cold water prepared in the same manner as the carbon dioxide-containing cold water with this initial concentration of 1000 ppm was sealed inside the above container (the same applies to the following examples, etc.). Film composition: Ether-based thermoplastic polyurethane elastomer (Elastoran 1180A, manufactured by BASF), film thickness 200 μm. (Comparative Example 1) In Example 1, a body cooling device container was prepared, and 1650 mL of cold water at a temperature of 1°C was sealed inside as the contents to create a body cooling device that does not release carbon dioxide to the outside of the container (no carbon dioxide release).

[0039] Then, using these, a body cooling effect confirmation test was conducted as follows. Specifically, for the subjects (men in their 40s), a 30-minute acclimatization period and standardization of pre-test meals were first performed. The measurement time (test duration) for the subjects was also standardized. The subjects then exercised in a hot environment (35°C, 80% relative humidity) indoors using a bicycle ergometer at an intensity of 80-85% HRM (heart rate 130-150) until their rectal temperature rose by approximately 1.0°C (approximately 25-35 minutes). Immediately after this exercise, either the body cooling device described in Example 1 or Comparative Example 1 was applied directly to the neck (direct contact application to the skin of the neck), and the subjects rested while cooling for 10 minutes (application time 10 minutes). After that, the body cooling device was removed, and the subjects rested for another 40 minutes.

[0040] In this study, core body temperature (deep body temperature) was measured by rectal temperature every 0.5 minutes starting 30 minutes after exercise, and skin surface temperature (surface temperature of the skin) was measured every 0.5 minutes after application of the body cooling device. Furthermore, as a sensory evaluation, a questionnaire was administered every 5 minutes after application of the body cooling device to rate the comfort level of internal body temperature (the degree of comfort or discomfort felt from the internal body temperature) on a 5-point scale from pleasant (1.0) to normal (3.0) to unpleasant (5.0). In addition, the temperature sensation on the skin surface of the application area was evaluated on a 9-point scale from too cold to use (0), too cold to use (1), cold (2) to comfortable (4), and not very cold (5) to hot (8). These sensory evaluations were judged from the following perspectives.

[0041] Body temperature comfort: In addition to determining whether the body cooling device has an immediate effect, we used the temperature comfort value at 25 minutes (15 minutes after removing the body cooling device) as a baseline to comprehensively assess whether the effect lasts over time. A smaller value indicates greater comfort, a value around 3.0 is average, and a value of 4.0 or higher indicates discomfort. Temperature sensation of the skin surface at the application site: To determine the temperature sensation (coldness / comfort) while the body cooling device is in use, the numerical value of the temperature sensation immediately after application (0 minutes) was used as the baseline. A value of 3 to 4 indicates a range where it is cool and comfortable, a value less than 3 indicates a range where it is too cold and comfort is reduced, and a value greater than 4 indicates a range where it is not cool enough and comfort is reduced.

[0042] These results are shown in Table 1 and Figures 4-11 below (Figures 4 and 5: Changes in core body temperature, Figures 6 and 7: Temperature comfort, Figures 8 and 9: Skin surface temperature of the application area, Figures 10 and 11: Temperature sensation of the application area). The values ​​for the rate of decrease in core body temperature, core body temperature after 25 minutes, minimum skin surface temperature during cooling, internal body temperature comfort after 25 minutes, and temperature sensation immediately after application, calculated from the above, are also shown in Table 1 below. These results show that applying a body cooling device (Example 1), which is obtained by filling a container for a body cooling device with carbon dioxide-containing cold water at a predetermined temperature and carbon dioxide concentration, into a container for a body cooling device that has a main body made of a single-layer film of ether-based thermoplastic polyurethane elastomer having a predetermined thickness (i.e., a single-layer integrated structure of ether-based thermoplastic polyurethane elastomer film in which control members including a carbon dioxide emission control member and a temperature control member are integrated into a single layer), to the body can efficiently lower the core body temperature without overcooling the skin surface in contact with it, and also reduces discomfort such as local pain, compared to applying a body cooling device (Comparative Example 1) that simply has cold water filled into it to the body. Although specific data are not shown, it has become clear that even when similar tests were conducted using body cooling devices that do not release carbon dioxide to the outside of the container and have different constituent materials, such as the neck cooling device described in Patent Document 1 (Cool Neck Ring, manufactured by TAT Co., Ltd.) or other neck coolers (vinyl chloride material, manufactured by YM Tech Co., Ltd.), the results would be almost the same as or worse than those of Comparative Example 1.

[0043] [Table 1]

[0044] (Example 2) In this embodiment, a body cooling device container prepared in Example 1 was filled with 1650 mL of carbon dioxide-containing cold water at a temperature of 1°C and a carbon dioxide concentration of 1000 ppm, similar to Example 1. Furthermore, when worn on the body, an ether-based thermoplastic polyurethane elastomer film (film thickness of 100 μm), similar to that in Example 1, was cut to create an intervening layer between the device and the neck (skin surface), and sandwiched between the skin-contacting surface as part of the control member. In other words, this embodiment provided a body cooling device in which a part of the control member is detachable. (Reference example 1) As a material to be sandwiched between the surfaces that come into contact with the skin, we use spunbond nonwoven fabric (Syntex PS-103, basis weight 16g / m²) manufactured by Mitsui Chemicals, Inc. 2 The body cooling device was the same as in Example 2, except that it used ). Using Example 2 and Reference Example 1, a group of three subjects (men in their 40s to 60s) were formed, and a body cooling effect confirmation test and sensory evaluation were conducted under the same conditions as in Example 1. The results (numerical values ​​for internal body temperature comfort after 25 minutes and temperature sensation immediately after application) are shown in Table 2. These results were also shown to be almost the same as those of Example 1.

[0045] [Table 2]

[0046] (Examples 4-13, Reference Example 2, Comparative Example 2) The carbon dioxide permeation rate (carbon dioxide emission rate) confirmation test was conducted as follows. Specifically, first, the following films or sheets (1) to (5) were prepared. (1) Single-layer film or single-layer sheet used in Example 1 (ether-based thermoplastic polyurethane elastomer (indicated as TPU), with four thicknesses: 100 μm (Example 4), 200 μm (Example 5), 300 μm (Example 6), and 600 μm (Example 7)) (2) Single-layer film or single-layer sheet obtained by compression molding of Mirable-type silicone rubber (silicone rubber, with five thicknesses: 100 μm (Example 8), 200 μm (Example 9), 300 μm (Example 10), 600 μm (Example 11), and 2000 μm (Example 12)) (3) The TPU film used in Example 2 (film thickness 100 μm) is placed on the upper surface (corresponding to the surface that comes into contact with the skin) of the TPU film with a film thickness of 200 μm used in Example 1, as described below: Example 13 (4) On the upper surface (corresponding to the surface in contact with the skin) of the 200 μm thick TPU film used in Example 1, the spunbond nonwoven fabric (Syntex PS-103 (indicated as Syntex), basis weight 16 g / m²) manufactured by Mitsui Chemicals, Inc., used in Reference Example 1, was placed. 2 ) is arranged as described below: Reference Example 2 (5) Single-layer film made of linear low-density polyethylene (LLDPE) as the constituent material (film thickness 100 μm): Comparative Example 2

[0047] Then, in an environment of room temperature at 25°C ± 1°C, the above film or sheet (70 mm wide x 70 mm long) was placed over the mouth of a 450 mL UM glass bottle (which had been pre-purged with nitrogen gas) in a smooth state without gaps or wrinkles (not stretched), and the edges of the opening were securely fixed with tape. In (3), the TPU film (film thickness 100 μm) was placed on the inside (the side that covers the glass bottle, opposite to the surface that comes into contact with the liquid described later) and fixed to the mouth of the bottle. The spunbond nonwoven fabric in (4) was done in the same manner. After that, an empty UM glass bottle of the same capacity and material that had been purged with nitrogen was filled to the brim with carbon dioxide-containing water with a carbon dioxide concentration of 1000 ppm at 25°C ± 1°C, and immediately the above glass bottles with the film or sheet fixed on top were placed on top of each other without any gaps (so that there were no air gaps between the liquid surface and the film or sheet) so that the mouth of the bottle was sealed, and the bottles were wrapped with plastic wrap. In the control group, empty bottles without film or sheets were stacked and packaged in the same manner. After 1 minute, 5 minutes, 10 minutes, or 30 minutes, the empty bottles were removed, the film or sheet was removed, and they were immediately sealed with plastic wrap. Two minutes after sealing, the carbon dioxide concentration inside the empty bottles was measured using a carbon dioxide detector (GASTEC, gas detection tube "2LC" and gas sampler "GV-100S"). This measurement was repeated three times, and the average of these three measurements (average amount of detected carbon dioxide, mL / m³) was taken. 2 The value ) was defined as "carbon dioxide permeation rate (i.e., carbon dioxide emission rate)". The measurement environment was 25°C ± 1°C with a relative humidity of 70%. The detected carbon dioxide amount was calculated using the conversion formula from the detector tube indicator gas concentration (ppm) disclosed by the manufacturer.

[0048] The results are shown in Table 3 below. A carbon dioxide emission curve was also created from the carbon dioxide emission amount after 1 minute and the total carbon dioxide emission amount up to 10 minutes (not shown). From these results, it was found that, based on their physical properties, Examples 4-7 and 13, which are films or sheets made of ether-based thermoplastic polyurethane elastomer, and Examples 8-12, which are films or sheets made of silicone rubber, when used to form the containment area and control member of a body cooling device container, emit 3.2 mL / m² per minute after enclosing a contents with an initial carbon dioxide concentration of 1000 ppm. 2 The above amount of carbon dioxide release can be sustained for more than 5 minutes, and the total amount released up to 10 minutes after sealing the contents is 30 mL / m³. 2 It became clear that the amount of carbon dioxide released could exceed the above. In other words, because the amount of carbon dioxide released after enclosing a contents with a carbon dioxide concentration of 1000 ppm or more can be controlled as described above, it was shown that a body cooling device configured in this way can allow a large amount of carbon dioxide to penetrate the body in the initial stages of application, quickly prevent vasoconstriction, and allow a sufficient amount of carbon dioxide to penetrate the body within a certain application time, making it easier to lower core body temperature. Reference Example 2 yielded generally similar results. On the other hand, Comparative Example 2, a film made of linear low-density polyethylene (LLDPE), showed some carbon dioxide permeation after 1 minute, but no further carbon dioxide permeation was observed thereafter.

[0049] [Table 3]

[0050] Furthermore, as can be seen from the upward-convex curves when plotting the carbon dioxide release rates for each case, the amount of carbon dioxide released gradually decreases over time. However, when calculating the amount of carbon dioxide released per minute from the total amount of carbon dioxide released after 10 minutes, the result for Examples 4-13 is 3.2 mL / m³. 2Furthermore, when comparing this value with the carbon dioxide release rate in the first minute, it was found that the carbon dioxide release rate in the first minute was higher. In addition, in Examples 4-13, the carbon dioxide release rate after 5 minutes was 16 mL / m³. 2 (3.2 mL / m²) 2 Since it exceeds five times the amount and the carbon dioxide release curve is convex upwards, it is 3.2 mL / m³ per minute. 2 It was found that the above carbon dioxide emissions continued for more than 5 minutes. The results for Reference Example 2 were generally similar.

[0051] <Evaluation of film or sheet strength (tear strength)> Furthermore, the tear strength of each sample was measured according to JIS K7128-3 using the following method. (1) Sampling: The sample was taken with the longitudinal direction of the sample as the long side of the test specimen (100 mm). (2) Test speed: 200 mm / min. (3) Measurement: After leaving the test specimen at 25°C and 55%RH for 24 hours, a tensile test was performed using Tensilon UCT-100W (manufactured by Orientec Co., Ltd.) at the speed specified in (2) above, and the value (N) measured was defined as the breaking strength. If the specimen did not break even when it reached a strength of 20N, the strength was defined as "20N or higher". (4) Measurements were taken three times, and the average value (N) was defined as the "tear strength". The values ​​obtained reflect the durability against impacts such as when a container containing its contents is dropped. Based on evaluations using TPU film, a tear strength of 10N or higher is generally preferred. These results are shown in Table 4 below.

[0052] <Evaluation of blood flow enhancement effect> In addition, the blood flow-enhancing effect of each sample was evaluated using the following method. First, a bottle similar to the one used for carbon dioxide permeability evaluation described above was prepared. The subjects were then allowed to acclimate to the environment by resting for 30 minutes in a 25°C, 50% RH environment. At this time (immediately afterward), the blood flow enhancement evaluation described later was performed to check skin color (skin flushing) and total hemoglobin level, which were then defined as the initial state. Then, each sample was filled to the brim with carbonated water in the bottle as described above, and then secured to the bottle opening, taking care to prevent leakage. At this time, the composite material of the sample (100 μm TPU film in Example 13, spunbond nonwoven fabric in Reference Example 2) was secured so that it was on the opposite side from the liquid. Immediately after securing the sample, the inside of the subject's forearm, which had been moistened with gauze soaked in pure water beforehand, was pressed tightly against the bottle opening and held for 5 minutes. After that, the skin tone (skin flushing) at the point of contact with the bottle opening was visually checked and evaluated in the following three stages by comparing it with the initial state. ○: The entire circular area around the neck of the bottle is clearly flushed red. △: A small, indistinct area around the bottle neck is reddened, or the entire area is slightly reddened. ×: No color change occurs. This assessment indicates that the more the skin flushing progresses, the greater the increase in blood flow in the epidermal capillaries.

[0053] Furthermore, after the visual inspection described above, the total hemoglobin amount (total hemoglobin volume) up to a depth of 5 mm was measured using a tissue blood oxygen monitor (NIRS, BOM-L1 TRSF, OMEGAWAVE, Inc.). Since the device allows for movement of the measurement probe, three measurements were taken by moving the measurement position, and the average value was calculated. This evaluation means the total amount of hemoglobin up to a depth of 5 mm (deep tissue) (×10,000 cells / mm³). 3 Since the resulting values ​​reflect this, it can be said that they represent the degree of increased blood flow in the deep tissues. In the two evaluations described above, if both are elevated, it indicates increased blood flow from the skin surface to the deeper layers of the body. Therefore, even with localized cooling of the neck, it is possible to lower the internal body temperature (core body temperature) without significantly lowering the minimum temperature of the skin surface, as shown in Example 1 of Table 1. The initial state immediately after environmental acclimatization, which serves as the standard, is as follows: Skin flushing: × (no flushing), Total hemoglobin amount (~5mm): 17.2 (× 10,000 cells / mm²) 3 ) These results are also shown in Table 4 below.

[0054] [Table 4]

[0055] The results in Tables 3 and 4 show that TPU (including multilayer structures) and silicone rubber of a specified thickness exhibit sufficient carbon dioxide permeability while ensuring durability during use. Furthermore, these also indicate that, similar to the results of Example 1 shown in Table 1 (effectively lowering core body temperature while suppressing excessive decrease in skin surface temperature), increased blood flow from the skin surface to the deeper tissues occurs due to the effect of carbon dioxide. In addition, based on this tear strength (durability) and carbon dioxide permeability, the thickness (total thickness) of these films or sheets is particularly suitable in the range of 200 to 600 μm when composed of TPU, and particularly suitable in the range of 300 to 2000 μm when composed of silicone rubber.

[0056] Furthermore, the above embodiment encompasses the following technical concepts. <1> A body cooling device that contains a container with a refrigerant and a carbon dioxide release source, and is used by contacting the skin in such a way that the released carbon dioxide permeates the body, A control member is provided in the skin contact area, which is the area that comes into contact with the skin during application. The control member is made of a thermoplastic polyurethane elastomer (more preferably an ether-based thermoplastic polyurethane elastomer) or silicone rubber (more preferably millable-type silicone rubber), and includes a carbon dioxide emission control member that controls the amount of carbon dioxide released from the inside, and a temperature control member that controls the surface temperature of the surface that comes into contact with the skin. Body cooling equipment. <2> The control member has a single-layer integrated structure in which the carbon dioxide emission control member and the temperature control member are integrated into a single layer. <1> Body cooling devices as described above. <3> The control member is a film or sheet made of thermoplastic polyurethane elastomer with a total thickness of 100 to 600 μm (more preferably 200 to 600 μm), or a film or sheet made of silicone rubber with a total thickness of 100 to 2000 μm (more preferably 200 to 2000 μm, even more preferably 300 to 2000 μm). <1> or <2> Body cooling devices as described above. <4> The carbon dioxide release rate is 3.2 mL / m³ per minute after the contents are sealed. 2 This amount is sufficient to last for more than 5 minutes. <1> ~ <3> A body cooling device as described in any one of the following. <5> The carbon dioxide release amount is 30 mL / m³, which is the total amount released up to 10 minutes after the contents are sealed inside. 2 This is the amount that is greater than or equal to the above. <1> ~ <4> A body cooling device as described in any one of the following. <6> When the temperature of the contents is set to 1°C or more and 5°C or less, and more specifically, 1°C or more and 3°C or less, the surface temperature of the skin opposite the surface in contact with the skin is 18°C ​​or more and 25°C or less. <1> ~ <5> A body cooling device as described in any one of the following. <7> The control member includes at least one selected from the group consisting of woven fabric, nonwoven fabric, natural rubber, synthetic rubber, synthetic resin, foamed plastic, paper, and metal. <1> ~ <6> A body cooling device as described in any one of the following. <8> A container for a body cooling device that encloses a contents containing a refrigerant and a carbon dioxide release source, and is used by allowing the released carbon dioxide to permeate the body and come into contact with the skin, The system comprises a containment area capable of containing and sealing the contents, and a skin contact area which includes a surface that comes into contact with the skin during application, with a control member. The control member is made of a thermoplastic polyurethane elastomer (more preferably an ether-based thermoplastic polyurethane elastomer) or silicone rubber (more preferably millable-type silicone rubber), and includes a carbon dioxide emission control member that controls the amount of carbon dioxide released from the inside, and a temperature control member that controls the surface temperature of the surface that comes into contact with the skin. Container for body cooling equipment. <9> The control member has a single-layer integrated structure in which the carbon dioxide emission control member and the temperature control member are integrated into a single layer. <8> A container for body cooling devices as described above. <10> The control member is a film or sheet made of thermoplastic polyurethane elastomer with a total thickness of 100 to 600 μm (more preferably 200 to 600 μm), or a film or sheet made of silicone rubber with a total thickness of 100 to 2000 μm (more preferably 200 to 2000 μm, even more preferably 300 to 2000 μm). <8> or <9> A container for body cooling devices as described above. <11> The control member includes at least one selected from the group consisting of woven fabric, nonwoven fabric, natural rubber, synthetic rubber, synthetic resin, foamed plastic, paper, and metal. <8> ~ <10> A container for body cooling devices as described in any one of the following. <12> When carbon dioxide-containing water having an initial carbon dioxide concentration of 1000 ppm or more, more preferably 1000 ppm, is enclosed as the container, the carbon dioxide release rate is controlled by the container and the control member including the carbon dioxide release rate control member to 3.2 mL / m³ per minute after the container is enclosed. 2 It is controlled so that it can be maintained for more than 5 minutes. <8> ~ <11> A container for body cooling devices as described in any one of the following. <13> When carbon dioxide-containing water with an initial carbon dioxide concentration of 1000 ppm or more, more preferably 1000 ppm, is enclosed as the container, the carbon dioxide release amount is controlled by the container and the control member including the carbon dioxide release amount control member, so that the total amount of carbon dioxide released up to 10 minutes after the container is enclosed is 30 mL / m³. 2 It is controlled to be above the above. <8> ~ <12> A container for body cooling devices as described in any one of the following. <14> When the aforementioned contents are enclosed in a container with a temperature of 1°C to 5°C, or even 1°C to 3°C, the surface temperature of the skin opposite the surface in contact with the skin is controlled to be between 18°C ​​and 25°C. <8> ~ <13> A container for body cooling devices as described in any one of the following. [Explanation of symbols]

[0057] 100 Body cooling equipment 101 Container for body cooling equipment 201 Inner container 203 Outer container 10 Control Member 11 Carbon dioxide emission control member 13 Temperature control member 21 Inlet section 31 Main body 41 Containment Area 51 Skin contact area

Claims

1. A body cooling device that contains a container with a refrigerant and a carbon dioxide release source, and is used by contacting the skin in such a way that the released carbon dioxide permeates the body, A control member is provided in the skin contact area, which is the area that comes into contact with the skin during application. The control member is made of thermoplastic polyurethane elastomer or silicone rubber and includes a carbon dioxide emission control member that controls the amount of carbon dioxide released from the inside, and a temperature control member that controls the surface temperature of the surface that comes into contact with the skin. Body cooling equipment.

2. The body cooling device according to claim 1, wherein the control member has a single-layer integrated structure in which the carbon dioxide emission control member and the temperature control member are integrated into a single layer.

3. The carbon dioxide release rate is 3.2 mL / m³ per minute after the contents are sealed. 2 The body cooling device according to claim 1 or 2, wherein the amount is sufficient to last for five minutes or more.

4. The carbon dioxide release amount is 30 mL / m³, which is the total amount released from the time the contents are sealed until 10 minutes have elapsed. 2 The body cooling device according to claim 1 or 2, wherein the amount is greater than or equal to the above.

5. The body cooling device according to claim 1 or 2, wherein when the temperature of the contents is set to 1°C or more and 5°C or less, the surface temperature of the skin opposite the surface in contact with the skin is 18°C ​​or more and 25°C or less.

6. A container for a body cooling device that encloses a contents containing a refrigerant and a carbon dioxide release source, and is used by allowing the released carbon dioxide to permeate the body and come into contact with the skin, The system comprises a containment area capable of containing and sealing the contents, and a skin contact area which includes a surface that comes into contact with the skin during application, with a control member. The control member is made of thermoplastic polyurethane elastomer or silicone rubber and includes a carbon dioxide emission control member that controls the amount of carbon dioxide released from the inside, and a temperature control member that controls the surface temperature of the surface that comes into contact with the skin. Container for body cooling equipment.

7. The container for a body cooling device according to claim 6, wherein the control member has a single-layer integrated structure in which the carbon dioxide release amount control member and the temperature control member are integrated into a single layer.

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