Oil-in-water emulsion composition and cosmetics

Abstract

To provide an oil-in-water emulsion composition that has moderate viscosity, excellent usability, good product stability, and contains a naturally derived thickener. [Solution] An oil-in-water emulsion composition containing a sulfated polysaccharide derived from Suizenji-nori, an oily component, and an aqueous medium; a cosmetic containing the oil-in-water emulsion composition.

Description

Technical Field

[0001] The present invention relates to an oil-in-water type emulsion composition and a cosmetic containing the oil-in-water type emulsion composition.

Background Art

[0002] Since an oil-in-water type emulsion composition (O / W emulsion) can provide a refreshing touch by making the texture when applied to the skin relatively light, it is widely used as a dosage form of cosmetics. In addition to the light texture, the merits of the oil-in-water type composition include the moisturizing effect by oil components, skin permeability, and the ability to use any active ingredients, whether water-soluble or fat-soluble. On the other hand, since cosmetics are required to maintain their quality for a long time under appropriate conditions, in the oil-in-water type emulsion composition, it is required that the emulsified particle size due to oil droplets in the aqueous phase is small and the emulsion is stable.

[0003] In addition, thickeners are often added to cosmetics for the purpose of improving texture, improving the spreadability on the skin, improving product stability, and achieving uniform distribution of active ingredients. In many cases, thickeners are also added to oil-in-water type compositions for cosmetics. Conventionally, polyacrylic acid-based polymers typified by carboxyvinyl polymer have been used as thickeners (for example, Patent Document 1). Although carboxyvinyl polymer can form a fresh gel in a small amount, from the perspective of environmental consideration, a natural-derived thickener to replace carboxyvinyl polymer has long been desired. In recent years, natural polymers such as polysaccharides including xanthan gum have been used as natural-derived thickeners. However, when a large amount of xanthan gum is used to exhibit thickening properties, there is a problem that the touch becomes sticky. Therefore, a new bio-derived thickener that can impart an excellent feeling of use while maintaining appropriate viscosity and product stability of the whole cosmetic is desired by replacing xanthan gum or using it in combination with xanthan gum.

[0004] On the other hand, sulfated polysaccharides derived from the freshwater cyanobacterium Aphanothece sacrum are known to have excellent moisturizing properties and have been proposed as cosmetic ingredients (see, for example, Patent Documents 2-3). The potential for reducing inflammation and restoring the skin barrier function through the use of these sulfated polysaccharides has also been reported (see Non-Patent Document 1). [Prior art documents] [Patent Documents]

[0005] [Patent Document 1] Patent No. 3828700 [Patent Document 2] Patent No. 4066443 [Patent Document 3] International Publication No. 2022 / 244334 [Non-patent literature]

[0006] [Non-Patent Document 1] Ngatu et al., “Anti-allergic and Profilaggrin(ProFLG)-mRNA expression modulatory effects of sacran,” International Journal of Biological Macromolecules, No. 105, 2017, p1532-1538 [Overview of the project] [Problems that the invention aims to solve]

[0007] In oil-in-water emulsion compositions, no naturally derived thickener has been found that can achieve both a good overall texture and appropriate viscosity, and no oil-in-water emulsion compositions containing such a thickener were known. Furthermore, when manufacturing oil-in-water emulsion compositions, emulsifiers (surfactants) are added. Therefore, there has been a need for a thickener that can be used in combination with emulsifiers in oil-in-water emulsion compositions and that can contribute to the particle size of the emulsified oil droplets in the aqueous phase and the stability of the product.

[0008] The present invention has been made in view of the above problems, and aims to provide an oil-in-water emulsion composition that has appropriate viscosity and excellent usability, good product stability, and contains a naturally derived thickener. [Means for solving the problem]

[0009] The inventors of the present invention conducted intensive research to solve the above problems and, as a result, discovered that naturally derived sulfated polysaccharides from Suizenji-nori function as a thickening agent, resulting in an oil-in-water emulsion composition with appropriate viscosity and excellent usability. They also found that the oil-in-water emulsion composition containing Suizenji-nori-derived sulfated polysaccharides has appropriately small emulsion particle sizes in the aqueous phase, resulting in high product stability. Based on these findings, the inventors completed the present invention.

[0010] In other words, the present invention provides the following invention. (1) An oil-in-water emulsion composition containing sulfated polysaccharides derived from Suizenji-nori, an oily component, and an aqueous medium. (2) The oil-in-water emulsion composition according to (1), wherein the content of the sulfated polysaccharide derived from Suizenji-nori in the oil-in-water emulsion composition is 0.05% by mass to 0.5% by mass. (3) A cosmetic composition containing the oil-in-water emulsion composition of (1) or (2) above. [Effects of the Invention]

[0011] According to the present invention, an oil-in-water emulsion composition with appropriate viscosity, excellent usability, and good emulsification stability can be obtained. Furthermore, since the sulfated polysaccharide derived from Suizenji-nori is an algae-derived component, it can be used safely and securely compared to synthetic components derived from petroleum raw materials. In addition, the sulfated polysaccharide derived from Suizenji-nori itself is expected to have moisturizing effects, skin barrier effects, anti-inflammatory effects, etc., and can improve various skin functions and skin conditions not only as a thickening agent but also in other ways. [Modes for carrying out the invention]

[0012] The present invention will be described in more detail below. However, the present invention is not limited to the embodiments shown below. In this specification, unless otherwise specified, "parts" and "%" mean "parts by mass" and "% by mass," respectively. In this specification, unless otherwise specified, "XX or greater and YY or less" or "XX to YY" means a numerical range including the lower and upper limits which are the endpoints. When a numerical range is described in steps, the upper and lower limits of each numerical range can be combined in any way.

[0013] (Oil-in-water emulsion composition) The oil-in-water emulsion composition of the present invention (hereinafter sometimes simply referred to as "emulsified composition" or "composition") contains sulfated polysaccharides derived from Suizenji-nori, an oily component, and an aqueous medium. Each component will be described below.

[0014] • Sulfated polysaccharides derived from Suizenji-nori The sulfated polysaccharide derived from Aphanothece sacrum (hereinafter sometimes simply referred to as "sulfated polysaccharide" or "polysaccharide") is a kind of sulfated polysaccharide derived from the freshwater cyanobacterium Aphanothece sacrum obtained naturally or by cultivation (culture), and generally has an average molecular weight of 2,000,000 or more. Specifically, it has a repeating structure of sugar chain units in which a sugar structure having a hexose structure and a sugar structure having a pentose structure are linked linearly or branched by an α-glycoside bond or a β-glycoside bond, the sugar chain unit contains a sulfated sugar as a sugar structure, and in the sugar chain unit, 2.7 or more hydroxyl groups per 100 hydroxyl groups are sulfated, or it is a sugar derivative in which sulfur element occupies 1.5 mass% or more in all elements.

[0015] Specific examples of the sulfated polysaccharide include sulfated muramic acid or sulfated N-acetylmuramic acid.

[0016] The sulfated polysaccharide contains at least glucose, galactose, mannose, galactosamine, xylose, arabinose, glucuronic acid, galacturonic acid, fucose, and rhamnose, and a functional group selected from a functional group group containing at least a sulfate group, a lactate group, and a methyl group may be bonded at any bonding position in these sugar structures. The sulfate group, which is a characteristic of the sulfated polysaccharide derived from Aphanothece sacrum, is preferably contained in the sulfated polysaccharide at 3 to 20 mass%, more preferably 5 to 15 mass%, and even more preferably 8 to 12 mass%.

[0017] A part of the sugar structure constituting the sulfated polysaccharide may be further bonded to a peptide or a lipid.

[0018] The molar ratio of the main sugar structures constituting the sulfated polysaccharide may be arabinose 1.1: fucose 3.7: rhamnose 15.4: xylose 17.0: mannose 10.5: galactose 12.3: galacturonic acid 4.6: glucuronic acid 4.7: glucose 28.8: galactosamine 2.03. Also, the number of types of sugar structures (monosaccharides) constituting the sulfated polysaccharide may be 5 or more, 7 or more, 8 or more, 10 or more.

[0019] The average molecular weight of the sulfated polysaccharide is, for example, 500,000 or more, 800,000 or more, 1,000,000 or more, 2,000,000 or more, 5,000,000 or more, 10,000,000 or more, 20,000,000 or more, etc., and 30,000,000 or less, 28,000,000 or less, 25,000,000 or less, 22,000,000 or less, etc. Combinations that are not contradictory may also be used. For example, 1,000,000 to 30,000,000, 5,000,000 to 28,000,000, 10,000,000 to 25,000,000, 20,000,000 to 22,000,000, etc.

[0020] The sulfated polysaccharide may be extracted, isolated, and purified from Undaria pinnatifida. The method for extracting the sugar derivative from Suizenji-nori is not particularly limited, and conventional methods such as those described in Patent Document 5 can be used. Specifically, for example, the following can be used: A suitable amount of Suizenji-nori is frozen and thawed, then washed with water to remove water-soluble pigments, and then lipid-soluble pigments are removed by stirring with an organic solvent such as ethanol for 24 hours. After separating the organic solvent from the Suizenji-nori from which the pigments have been removed, the solvent is dissolved in an aqueous solution of sodium hydroxide, for example, at 40 to 80°C, while stirring for 5 to 12 hours. The aqueous solution of the sugar derivative extracted by this operation is neutralized with concentrated hydrochloric acid, for example. Here, desalting may or may not be performed by immersing in 60 to 80% isopropyl alcohol, for example. After that, the solution is poured into 100% isopropanol while stirring to precipitate a gel-like sugar derivative, and then dried with hot air. Drying with hot air may be at 85 to 100°C or higher for 6 to 24 hours, for example. In another example, a sugar derivative is extracted from Suizenji-nori by heating an aqueous dispersion of Suizenji-nori in an autoclave at 135°C for 30 minutes. The extracted sugar derivative may be purified by centrifugation, filtration, or alcohol washing. Alternatively, before extracting the sugar derivative from Suizenji-nori, the Suizenji-nori may be frozen and then thawed, followed by a step to remove the pigment.

[0021] Sulfated polysaccharides may be commercially available products, such as "Sacran" (registered trademark) manufactured by Green Science Material (GSM) and "Sacranex" (registered trademark) manufactured by the DIC Group.

[0022] Furthermore, the sulfated polysaccharides may be present in a form that is included in the crushed dried product of Suizenji-nori (hereinafter referred to as "crushed dried product of Suizenji-nori"), insofar as they achieve the effects of the present invention. Therefore, the present invention can also provide an oil-in-water emulsion composition containing crushed dried Suizenji-nori containing sulfated polysaccharides as an active ingredient. The crushed dried Suizenji Nori containing the sugar derivative may be, for example, a crushed freeze-dried Suizenji Nori containing the sugar derivative, a crushed sun-dried Suizenji Nori containing the sugar derivative, or a crushed hot-air dried Suizenji Nori containing the sugar derivative, and any one of these may be used, or a combination of several may be used. Crushed dried Suizenji-nori containing sulfated polysaccharides can all be prepared by conventional methods. For example, crushed freeze-dried Suizenji-nori containing the aforementioned sugar derivatives can be prepared by freezing Suizenji-nori containing water in a low-temperature freezer, removing the water contained within the algae by vacuum freeze-drying to obtain freeze-dried Suizenji-nori, and then crushing it (for example, by grinding it with a mortar and pestle, or by grinding it into a powder using a pulverizer). After that, it may be suspended in an appropriate solvent or solution.

[0023] Furthermore, the sulfated polysaccharides may be present in an extract of Suizenji-nori (hereinafter referred to as "Suizenji-nori extract") insofar as they achieve the effects of the present invention. Therefore, the present invention can also provide an oil-in-water emulsion composition containing a Suizenji Nori extract containing sulfated polysaccharides as an active ingredient. Suizenji-nori extract containing sulfated polysaccharides can be prepared, for example, by the method described above.

[0024] In the oil-in-water emulsion composition of the present invention, the content of sulfated polysaccharides is not particularly limited, but is preferably 0.010% by mass or more, preferably 0.010% to 1.000% by mass, more preferably 0.030% to 0.800% by mass, even more preferably 0.050% to 0.500% by mass, particularly preferably 0.060% to 0.300% by mass, quite preferably 0.070% to 0.250% by mass, very preferably 0.075% to 0.200% by mass, and most preferably 0.080% to 0.150% by mass.

[0025] • Oily components The oily component is not particularly limited, and known components can be used. The oily component may be a component that is liquid, solid, or semi-solid at room temperature. Examples of oily components include hydrocarbons, higher alcohols, higher fatty acids, esters, silicone oils, and animal and vegetable oils.

[0026] Examples of hydrocarbons include squalane, mineral oil, liquid paraffin, light isoparaffin, dodecane, tetradecane, ozokerite, microcrystalline wax, ceresin, α-olefin oligomer, polybutene, hydrogenated polyisoparaffin, limonene, turpentine oil, and petrolatum.

[0027] Examples of higher alcohols include, Straight-chain or branched-chain alcohols with 8 to 24 carbon atoms, such as coconut oil alcohol, caprylic alcohol, caprin alcohol, lauryl alcohol, isostearyl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, arachidyl alcohol, behenyl alcohol, oleyl alcohol, isostearyl alcohol, hexyldecanol, 2-octyldodecanol, decyltetradecanol, batyl alcohol, etc. Examples include cholesterol and sterols such as phytosterols.

[0028] Examples of higher fatty acids include those with 8 to 24 carbon atoms, such as coconut oil fatty acid, isostearic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, oxystearic acid, palmitoleic acid, ricinoleic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), isostearic acid, and 12-hydroxystearic acid. These higher fatty acids may also be in the form of metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, sodium salts, and potassium salts, as well as amine salts such as ethanolamine salts, and nitrogen-containing derivatives such as amides.

[0029] Examples of esters include, Esters of linear fatty acids such as isopropyl myristate, isopropyl palmitate, and ethyl oleate with lower alcohols; Esters of linear fatty acids and linear higher alcohols, such as hexyl laurate, myristyl myristate, decyl oleate, stearyl stearate, and cetyl palmitate; Esters of straight-chain fatty acids such as octyldodecyl myristate, isostearyl palmitate, ethylhexyl stearate, and ethylhexyl palmitate with branched-chain alcohols; Esters of branched-chain fatty acids such as ethyl isostearate and isopropyl isostearate with lower alcohols; Esters of branched-chain fatty acids such as cetyl ethylhexanoate and hexyl isostearate with linear higher alcohols; Esters of fatty acids such as phytosteryl isostearate, phytosteryl oleate, and phytosteryl hydroxystearate with steroid alcohols; Esters of fatty acids such as di(isostearyl / phytosteryl) dimer dilinoleate, dimer dilinoleyl bis(behenyl / isostearyl / phytosteryl) dimer dilinoleate, and dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl) with alcohols and steroid alcohols; Esters of fatty acids and polyhydric alcohols such as propylene glycol dicaprylate, triethylhexanoin, caprylic / capric triglyceride, and caprylic / capric triglyceride (coconut alkyl); Esters of branched-chain fatty acids such as 2-octyldodecyl neopentanoate and isostearyl isostearate with branched-chain alcohols; Esters of hydroxycarboxylic acids such as lauryl lactate, trioctyldodecyl citrate, and diisostearyl malate with alcohols; Ester oils such as esters of dibasic acids like diisopropyl adipate and diethyl sebacate; Examples include wax esters such as jojoba oil, carnauba wax, candelilla wax, rice bran wax, beeswax, montan wax, sugarcane wax, and palm wax.

[0030] Examples of silicone oils include methylpolysiloxane (dimethicone), dimethylpolysiloxane, methylphenylpolysiloxane, dodecamethylcyclohexasiloxane, methylhydrogenpolysiloxane, and dimethylsiloxane. There are no particular restrictions on the kinematic viscosity of silicone oil at 25°C, and it can be appropriately selected depending on the purpose, but 100 mm at 25°C is not recommended. 2 Preferably less than / s, 50mm 2 / s or less is preferable.

[0031] Examples of animal and vegetable oils include apricot kernel oil, camellia oil, argan oil, soybean oil, olive oil, castor oil, coconut oil, palm oil, palm kernel oil, sesame oil, perilla oil, jojoba seed oil, hydrogenated jojoba oil, cottonseed oil, rapeseed oil, linseed oil, rosehip oil, sunflower oil, essential oils, avocado oil, almond oil, rice bran oil, safflower oil, corn oil, grapeseed oil, coconut oil, argania spisano kernel oil, wheat germ oil, rice germ oil, kukui nut oil, cranbe abyssinica seed oil, hemp seed oil, peanut oil, sasanqua oil, evening primrose oil, pistachio oil, macadamia nut oil, meadowhome oil, cocoa butter, shea butter, and other vegetable oils; Examples include animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, and turtle oil.

[0032] The oily component may be used alone or in combination of two or more types. The oily component is preferably one or more selected from the group consisting of hydrocarbons, higher alcohols, esters, silicone oils, and vegetable oils.

[0033] In the oil-in-water emulsion composition of the present invention, the content of the oily component is not particularly limited, but is preferably 1.0% by mass or more, more preferably 3.0% by mass or more, even more preferably 5.0% by mass or more, even more preferably 8.0% by mass or more, and even more preferably 10.0% by mass or more. On the other hand, relative to the whole composition, it is preferably 50.0% by mass or less, more preferably 40.0% by mass or less, even more preferably 35.0% by mass or less, even more preferably 30.0% by mass or less, and even more preferably 25.0% by mass or less. Specifically, for example, it is 1.0% to 50.0% by mass, 3.0% to 40.0% by mass, 5.0% to 35.0% by mass, 8.0% to 30.0% by mass, or 10.0% to 25.0% by mass.

[0034] ·Aqueous medium In the present invention, examples of aqueous media include water, organic solvents miscible with water, and combinations thereof. The water may be any of the following: tap water, purified water, hard water, soft water, natural water, deep-sea water, electrolyzed alkaline ionized water, electrolyzed acidic ionized water, ionized water, cluster water, etc. As organic solvents, known solvents usable in cosmetics can be used, such as lower alcohols like ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols like propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; glycol ethers like diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and dipropylene glycol monoethyl ether; glycol ether esters like ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters like diethoxyethyl succinate and ethylene glycol disuccinate; and benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, and N-methylpyrrolidone.

[0035] The content of the aqueous medium is not particularly limited, but is preferably 40.0% by mass or more, more preferably 45.0% by mass or more, even more preferably 50.0% by mass or more, even more preferably 55.0% by mass or more, even more preferably 60.0% by mass or more, and even more preferably 65.0% by mass or more. On the other hand, it is preferably 90.0% by mass or less, more preferably 85.0% by mass or less, even more preferably 80.0% by mass or less, even more preferably 75.0% by mass or less, and even more preferably 70.0% by mass or less. Specifically, for example, it is 40.0% by mass to 90.0% by mass, 45.0% by mass to 85.0% by mass, 50.0% by mass to 80.0% by mass, 55.0% by mass or more to 75.0% by mass, 60.0% by mass to 70.0% by mass, or 65.0% by mass to 70.0% by mass.

[0036] ·emulsifier The oil-in-water emulsion composition of the present invention preferably contains an emulsifier. The emulsifier is not particularly limited and includes, for example, one or more surfactants selected from the group consisting of anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants.

[0037] As for anionic surfactants, Fatty acid soaps such as potassium coconut oil fatty acid (e.g., potassium cocoyl glutamate), potassium myristate, and potassium laurate; Alkyl sulfates such as potassium lauryl sulfate, sodium lauryl sulfate, triethanolamine lauryl sulfate, and sodium myristyl sulfate; Sodium polyoxyethylene lauryl ether sulfate, such as POE(2) sodium lauryl ether sulfate; Polyoxyethylene alkyl ether sulfates such as polyoxyethylene lauryl ether sulfate triethanolamine; Alkyl phosphates such as lauryl phosphate; Amino acid-based surfactants such as acylmethyltaurate and sodium lauroylmethylalanine; Examples include sulfonates such as sodium lauryl sulfoacetate; and so on.

[0038] Cationic surfactants include, Alkylammonium salts such as cetyltrimethylammonium chloride, stearyltrimethylammonium chloride (steartrimonium chloride), behenyltrimethylammonium chloride, lauryltrimethylammonium chloride, stearoxypropyltrimonium chloride, and quaternium-33; Alkylbenzylammonium salt; Stearylamine acetate; Polyoxyethylene alkylamines such as polyoxyethylene laurylamine and polyoxyethylene stearylamine; Stearamidopropyldimethylamine; Examples include benzalkonium chloride; etc.

[0039] Nonionic surfactants include, Polyoxyethylene sorbitan fatty acid esters such as POE(20) sorbitan monolaurate, POE(20) sorbitan monopalmitate, POE(6) sorbitan monostearate, POE(20) sorbitan monostearate, POE(20) sorbitan tristearate, POE(6) sorbitan monooleate, POE(20) sorbitan monooleate, POE(20) sorbitan trioleate, POE(20) sorbitan monoisostearate, etc. Polyethylene glycol fatty acid esters such as POE(10) monostearate, POE(25) monostearate, POE(40) monostearate, POE(55) monostearate, POE(10) monolaurate, POE(10) monooleate, PEG-20 sorbitan cocoate, etc. Polyoxyethylene alkyl ethers such as POE(4) lauryl ether, POE(9) lauryl ether, POE(21) ​​lauryl ether, POE(150) cetyl ether, POE(20) cetyl ether, POE(2) cetyl ether, POE(10) cetyl ether, POE(25) cetyl ether, POE(30) cetyl ether, POE(10) oleyl ether, POE(15) oleyl ether, POE(7) oleyl ether, POE(20) oleyl ether, POE(50) oleyl ether, POE(5) behenyl ether, POE(10) behenyl ether, POE(20) behenyl ether, POE(30) behenyl ether, POE(20) stearyl ether, etc. Polyoxyethylene polyoxypropylene alkyl ethers such as POE(20)POP(4) cetyl ether, POE(20)POP(8) cetyl ether, and POE(30)POP(6) decyltetradecyl ether; Polyoxyethylene sorbitan fatty acid esters such as POE(60) sorbitan tetrastearate, POE(6) sorbitan tetraoleate, POE(30) sorbitan tetraoleate, POE(60) sorbitan tetraoleate, and POE(6) sorbitan monolaurate; Polyoxyethylene glycerin fatty acid esters such as PEG-20 glyceryl triisostearate, PEG-7 glyceryl cocoate, POE(15) glyceryl monostearate, POE(5) glyceryl monostearate, and POE(15) glyceryl monooleate; Polyoxyethylene castor oil / hydrogenated castor oil such as POE(40) castor oil, POE(20) hydrogenated castor oil, POE(40) hydrogenated castor oil, POE(50) hydrogenated castor oil, POE(60) castor oil, POE(60) hydrogenated castor oil, POE(80) hydrogenated castor oil, POE(100) hydrogenated castor oil, etc. Polyoxyethylene lanolin alcohols such as POE(10) lanolin alcohol, POE(20) lanolin alcohol, and POE(40) lanolin alcohol; Sorbitan fatty acid esters such as sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquistearate, sorbitan monooleate, sorbitan sesquioleate, and sorbitan trioleate; Glycerin fatty acid esters such as glyceryl monooleate, glyceryl monostearate, and glyceryl monomyristate; Diglycerin fatty acid esters such as diglyceryl monostearate, diglyceryl monooleate, and diglyceryl monoisostearate; triglycerin fatty acid esters such as triglyceryl monolaurate, triglyceryl monomyristate, triglyceryl monooleate, and triglyceryl monostearate; tetraglycerin fatty acid esters such as tetraglyceryl monostearate and tetraglyceryl monooleate; pentagglyceryl trimyristate, pentagglyceryl trioleate, pentagglyceryl monolaurate, pentagglyceryl monomyristate, pentagglyceryl monooleate, and pentagglyceryl monostearate; and pentagglycerin lipids such as pentagglyceryl trimyristate, pentagglyceryl trioleate, pentagglyceryl monolaurate, pentagglyceryl monomyristate, pentagglyceryl monooleate, and pentagglyceryl monostearate. Fatty acid esters, hexaglycerin fatty acid esters such as hexaglyceryl monooleate, hexaglyceryl monostearate, hexaglyceryl tristearate, hexaglyceryl monolaurate, hexaglyceryl monomyristate, and polyglycerin fatty acid esters such as decaglyceryl monostearate, decaglyceryl distearate, decaglyceryl diisostearate, decaglyceryl dioleate, decaglyceryl tristearate, decaglyceryl trioleate, decaglyceryl monolaurate, decaglyceryl monomyristate, decaglyceryl monooleate, decaglyceryl distearate; Alkyl glucosides such as lauryl glucoside; Fatty acid alkylolamides such as coconut oil fatty acid N-methylethanolamide and coconut oil fatty acid diethanolamide; Examples include alkyldimethylamine oxide solutions such as lauryldimethylamine oxide solution.

[0040] As for amphoteric surfactants, Betaine-type betaines such as lauryldimethylaminoacetic acid betaine (lauryl betaine), stearyl betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, stearyldimethylaminoacetic acid betaine, dodecylaminomethyldimethylsulfopropyl betaine, octadecylaminomethyldimethylsulfopropyl betaine, and other alkyl betaines; cocamidopropyl betaine, cocamidopropyl fatty acid amidopropyl betaine, cocamidopropyl fatty acid amidopropyl dimethylaminoacetic acid betaine (cocamidopropyl betaine), cocamidopropyl hydroxysultaine, and other fatty acid amidopropyl betaines; Alkylimidazole types such as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine; Amine oxide types such as lauryldimethylamine N-oxide, oleyldimethylamine N-oxide, and lauramine oxide; Examples include lecithins such as egg yolk lecithin, soy lecithin, hydroxylated lecithin, and hydrogenated lecithin.

[0041] As an emulsifier, one or more selected from the group consisting of nonionic surfactants and amphoteric surfactants are preferred. One or more nonionic surfactants selected from the group consisting of polyglycerin fatty acid esters, glycerin fatty acid esters, and sorbitan fatty acid esters are more preferred. Lecithin is more preferred as the amphoteric surfactant. Hydrogenated lecithin may also be used.

[0042] The degree of polymerization of the polyglycerin fatty acid ester is preferably 8 or higher, more preferably 9 or higher, while preferably 12 or lower, and more preferably 11 or lower. Specifically, the degree of polymerization of the polyglycerin fatty acid ester is, for example, 8 to 12, or 9 to 11. The fatty acids in polyglycerol fatty acid esters may be saturated or unsaturated fatty acids, and may have branched or linear chains. The number of carbon atoms in the fatty acid (hydrocarbon chain) of the polyglycerol fatty acid ester is preferably 12 or more, more preferably 14 or more, while preferably 20 or less, and more preferably 19 or less. Specifically, the number of carbon atoms is, for example, 12 to 20 or 14 to 19.

[0043] The fatty acids in glycerol fatty acid esters may be saturated or unsaturated fatty acids, and may have branched or linear chains. The number of carbon atoms in the fatty acid (hydrocarbon chain) of the glycerol fatty acid ester is preferably 16 or more, more preferably 17 or more, while preferably 20 or less, and more preferably 19 or less. Specifically, the number of carbon atoms is, for example, 16 to 20 or 17 to 19.

[0044] The fatty acids in sorbitan fatty acid esters may be saturated or unsaturated fatty acids, and may have branched or linear chains. The number of carbon atoms in the fatty acid (hydrocarbon chain) of the sorbitan fatty acid ester is preferably 15 or more, more preferably 16 or more, while preferably 19 or less, and more preferably 18 or less. Specifically, the number of carbon atoms is, for example, 15 to 19 or 16 to 18.

[0045] The emulsifier may be used alone or in combination of two or more types. The emulsifier content is not particularly limited, but is preferably 0.5% by mass or more, more preferably 1.0% by mass or more, even more preferably 1.5% by mass or more, even more preferably 2.0% by mass or more, and even more preferably 2.5% by mass or more. On the other hand, relative to the whole composition, it is preferably 15.0% by mass or less, more preferably 13.0% by mass or less, even more preferably 10.0% by mass or less, even more preferably 7.0% by mass or less, even more preferably 5.0% by mass or less, and even more preferably 4.5% by mass or less. Specifically, for example, it may be 0.5% to 15.0% by mass, 1.0% to 13.0% by mass, 1.5% to 10.0% by mass, 2.0% to 7.0% by mass, 2.5% to 5.0% by mass, 2.5% to 4.5% by mass, or 2.8% to 4.5% by mass.

[0046] The oil-in-water emulsion composition of the present invention can be used in various cosmetic applications such as skin cosmetics, hair cosmetics, or makeup cosmetics, and the dosage form of the cosmetic is not limited as long as the effects of the present invention can be obtained. The dosage forms include, for example, ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc., in a form suitable for use: 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or general-purpose skin cosmetics (for example; basic cosmetics such as lotions, toners, emulsions, creams, ointments, serums, beauty serums, and packs; facial cleansers and skin cleansers; massage agents, cleansing agents, depilatory agents, hair removal agents, shaving agents, aftershave lotions, preshave lotions, shaving creams; sunscreens, makeup bases, concealers, foundations, face powders, lipsticks, blushes, eyeshadows, eyeliners, mascaras, etc.) 1) Makeup cosmetics such as eyebrow products; perfumes, nail care products, nail enamel, nail enamel removers, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) Medicinal and / or cosmetic preparations applied to the scalp and hair (for example, shampoos, conditioners, hair treatments, pre-hair treatments, permanent solutions, hair dyes, hair styling products, hair tonics, hair growth and nourishing products, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) Bath additives used by adding them to bathwater, 6) Others include deodorants and antiperspirants, antiperspirants, antiperspirants, hygiene products, sanitary cotton, wet wipes, toothpastes, mouthwashes, gargles, dishwashing detergents, etc.

[0047] ·Optional ingredients In addition to the components described above, the oil-in-water emulsion composition of the present invention may contain optional components as long as they do not impair the effects of the present invention. Optional components include humectants, texture enhancers, various polymers, other thickeners, gelling agents, coloring pigments or pearl pigments, antioxidants, preservatives, antibacterial agents, chelating agents, pH adjusters, acids and alkalis, powders, UV absorbers, various active ingredients (whitening agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, antipruritics, etc.), vitamins and their derivatives, hormones, various extracts, and fragrances.

[0048] As humectants and texture enhancers, polyols and their polymers such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, pentylene glycol, and ethylene glycol-propylene glycol copolymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, and lactose Sugars and their derivatives such as raffinose, gluconic acid, glucuronic acid, β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, kerato sulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharides; fucoidan; tuberose polysaccharides and other natural Derived sulfated polysaccharides; organic acids such as citric acid, tartaric acid, and lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salt and other salts; amino acids such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, and taurine and their salts;Protein peptides and their derivatives such as collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degraded peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degraded peptides, keratin-degraded peptides, hydrolyzed keratin, conchiolin-degraded peptides, hydrolyzed conchiolin, silk protein-degraded peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein-degraded peptides, wheat protein-degraded peptides, hydrolyzed wheat protein, casein-degraded peptides, acylated peptides, etc.; palmitoyl oligopeptides, palmitoyl pentapeptides, palmitoyl tetrapeptides, etc. Preferred ingredients include ceramides; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesamin glycosides, glutathione, albumin, whey; choline chloride, phosphorylcholine; placental extract, aerlastin, collagen, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rose extract, yarrow extract, eucalyptus extract, sweet clover extract, and other animal and plant extracts; natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudoceramides, sphingoglycolipids, ceramides, and ceramide-containing extracts; and other ceramides.

[0049] Various polymers and other thickeners and gelling agents include guar gum, locust bean gum, queen seed gum, carrageenan, galactan, gum arabic, tara gum, tamarind, fercerelan, karaya gum, okra gum, tragacanth gum, pectin, pectic acid and its salts, alginic acid and its salts, mannan; starches from rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, Chitin, chitosan, agar, cassia seed extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder, and other cellulose and its derivatives; soluble starch, carboxymethyl starch, methylhydroxypropyl starch Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride starch, and corn starch aluminum octenyl succinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpyridone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate ester copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer and (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine;Polyesters, water-dispersible polyesters; polyacrylamides; polyacrylic acid ester copolymers such as ethyl polyacrylate, carboxyvinyl polymers (carbomers), salts such as polyacrylic acid and its sodium salts, acrylic acid / methacrylic acid ester copolymers; acrylic acid / alkyl methacrylate copolymers; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymers such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymers such as polyquaternium-22, acrylic acid / diallyldimethylammonium chloride / acrylamide copolymers such as polyquaternium-39, acrylic acid / cationized methacrylic acid ester copolymers, acrylic acid / cationized methacrylamide copolymers, acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymers such as polyquaternium-47, choline methacrylate chloride polymers; cationized oligosaccharides, cationized dextran, guar hydroxypropyltrimonium Preferred materials include cationized polysaccharides such as muchlorides; polyethyleneimines; cationic polymers; polymers of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and butyl methacrylate copolymers; polymer emulsions such as acrylic resin emulsions, ethyl polyacrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; anhydrous silicic acid, fuzzy silica (ultrafine particle anhydrous silicic acid), magnesium aluminum silicate, magnesium sodium silicate, metal soaps, dialkyl phosphate metal salts, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters.

[0050] In this specification, a coloring pigment is a component added for the purpose of coloring cosmetics, and is a pigment that exhibits color by absorbing light of a specific wavelength. On the other hand, in this specification, a pearl pigment is a component added primarily for the purpose of imparting luster (and color) similar to that of pearls or other shellfish, and mainly consists of an inorganic compound, or a coloring component may be attached to or coated on the inorganic compound. As coloring pigments, there are no particular limitations as long as they can be used in cosmetics, including inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and lower titanium oxide; inorganic purple pigments such as mango violet, manganese violet, and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; aluminum powder, etc. Examples include metal powder pigments such as vermiculite powder and gold; and synthetic organic pigments such as zirconium, barium, or aluminum lake, including Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3, and Blue 1. The pearl pigment is not particularly limited as long as it can be used in cosmetics. It can be made by coating the surface of inorganic granular plate-like powders such as mica, synthetic mica, synthetic fluorphlogopite, glass powder, silica, and alumina with colorants such as titanium dioxide, iron oxide, silicon dioxide, Prussian blue, chromium oxide, chromium hydroxide, gold, silver, carmine, or the aforementioned coloring pigments. Specifically, examples include titanium dioxide-coated mica, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, and bismuth oxychloride. The average particle size of the coloring pigment or pearl pigment is not particularly limited, but is preferably 2 to 250 μm. The content of coloring pigments or pearl pigments is not particularly limited and can be appropriately determined according to the desired color and texture, but is generally used in the range of 0.00001% to 0.1% by mass relative to the total composition.

[0051] Preferred antioxidants include alpha-lipoic acid, salts of alpha-lipoic acid, and derivatives of alpha-lipoic acid; tocopherol derivatives such as tocopherol (vitamin E), tocotrienol, and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride. Preferred reducing agents include thioglycolic acid, cysteine, and cysteamine. Preferred oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

[0052] As preservatives and antibacterial agents, hydroxybenzoic acids and their salts or esters such as methylparaben, ethylparaben, propylparaben, and butylparaben; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-diols such as 1,2-pentanediol and 1,2-hexanediol; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, and quaternary ammonium salts. The following are preferred: trichlorocarbanides, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenols, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol, and other phenols; ethylhexylglycerin, glyceryl caprylate, phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions.

[0053] Preferred chelating agents include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and their sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

[0054] Preferred pH adjusters and acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

[0055] Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium dioxide, fine and ultrafine titanium dioxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fuzzy silica (ultrafine anhydrous silicic acid), and titanium mica. Preferred materials include inorganic powders of various sizes and shapes such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorphlogopite, fine particle composite powders, gold, aluminum, and inorganic powders that have been hydrophobized or hydrophilized by treating them with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silanes or titanium coupling agents; organic powders of various sizes and shapes such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminated powder, polyethylene terephthalate-aluminum-epoxy laminated powder, urethane powder, silicone powder, Teflon® powder, and other organic powders and surface-treated powders, as well as organic-inorganic composite powders.Preferred inorganic salts include sodium chloride-containing salts such as table salt, regular salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; and sodium phosphates such as 1Na, 2Na, and 3Na phosphates, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0056] UV absorbers include benzoic acid-based UV absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxypara-aminobenzoate ethyl ester, N,N-diethoxypara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate butyl ester, and N,N-dimethylpara-aminobenzoate ethyl ester; anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid-based UV absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanolphenyl salicylate; and octyl cinnamate. Cinnamic acid-based UV absorbers such as ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy cinnamate, 2-ethylhexyl-p-methoxy cinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxy cinnamate (cinoxate), cyclohexyl-p-methoxy cinnamate, ethyl-α-cyano-β-phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy cinnamate, ferulic acid and its derivatives;Benzophenone-based UV absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydro Xy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzarazine; dianisioylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butyl methoxydibenzoylmethane; octyltriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanic acid; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole; Preferred materials include benzotriazole (nyl), 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, and other hydantoin derivatives, phenylbenzimidazol sulfonic acid, terephthalylidene dicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

[0057] Preferred whitening agents include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate, ascorbic acid fatty acid esters such as tetraisopalmitic ascorbic acid, alkyl ascorbic acid ethers such as ethyl ascorbic acid, ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, willow extract, saxifrage extract, and other plant extracts.

[0058] Preferred anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract.

[0059] Preferred hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, Capsicum tincture, Ginger tincture, Ginger extract, and Cantharis tincture; capsaicin, nonylic acid valenylamide, gingerol, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate; γ-oryzanol, nicotinic acid and derivatives such as nicotinamide, benzyl nicotinate, inositol hexanicotinate, and nicotinic alcohol; allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmamanol and its glycosides; and minoxidil.

[0060] Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance-P inhibitors. Examples of exfoliating and dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, and pyridoxine. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol and methyl salicylate. Examples of astringent agents include citric acid, tartaric acid, lactic acid, potassium aluminum sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

[0061] Other medicinal agents such as anti-wrinkle agents, anti-aging agents, firming agents, cooling agents, warming agents, wound healing promoters, irritation relievers, analgesics, and cell activators include retinols, retinoic acids, retinoic acid tocopheryl; lactic acid, glycolic acid, gluconic acid, fruit acids, salicylic acid and its glycosides and esters and their derivatives; hydroxycapric acid, long-chain α-hydroxy fatty acids, long-chain α-hydroxy fatty acid cholesteryl and other α- or β-hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and their derivatives; coenzyme Q10, carotene, lycopene, astaxanthin, lutein, etc. Preferred materials include antioxidants and free radical scavengers; catechins; flavonoids such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannins, sesamin, protoanthocyanidins, chlorogenic acid, and apple polyphenols; rutin and glycoside derivatives; hesperidin and glycoside derivatives; lignan glycosides; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; lactoferrin; gingerol; fragrance substances and their derivatives such as menthol, camphor, and cedrol; capsaicin, vanillin, and their derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances with cyclodextrins.

[0062] Vitamins and their derivatives include vitamin A compounds such as retinol, retinyl acetate, and retinyl palmitate; vitamin B compounds such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acid compounds, nicotinic acid compounds such as nicotinamide and benzyl nicotinate, and choline compounds; vitamin C compounds such as ascorbic acid and its sodium salts; vitamin D; vitamin E compounds such as α, β, γ, and δ-tocopherols; other vitamins such as pantothenic acid and biotin; and ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt. Preferred materials include ascorbic acid phosphate salts, ascorbic acid fatty acid esters such as tetraisopalmitic ascorbate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, alkyl ascorbic acid ethers such as ethyl ascorbate, ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate esters, tocotrienols, and various other vitamin derivatives.

[0063] Preferred hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.

[0064] Various extracts from plants, animals, and microorganisms include iris extract, angelica extract, Thujopsis dolabrata extract, asparagus extract, avocado extract, Hydrangea macrophylla extract, almond extract, Althaea extract, Arnica extract, apricot extract, apricot kernel extract, Ginkgo biloba extract, Inca extract, fennel extract, turmeric extract, oolong tea extract, bearberry extract, rosehip extract, Echinacea leaf extract, Enmeisou extract, Scutellaria baicalensis extract, Phellodendron amurense extract, Coptis japonica extract, barley extract, Panax ginseng extract, St. John's wort extract, and Lamium album. Grass extract, Ononis extract, Nasturtium officinale extract, Orange extract, Dried seawater, Seaweed extract, Persimmon leaf extract, Arctium moniliforme extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria lobata extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Artemisia capillaris extract, Oat extract, Chloranthus erythrosora extract, Licorice extract, Oil-soluble licorice extract, Kiwi extract, Kelpodium extract, Wood ear mushroom extract, Cinchona extract, Cucumber extract, Paulownia leaf extract, Guanosine, Guava extract, Sophora flavescens extract, Gardenia extract, Sasa veitchii extract Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Geranium thunbergii extract, black tea extract, yeast extract, Magnolia bark extract, coffee extract, burdock extract, rice extract, rice fermentation extract, rice bran fermentation extract, rice germ oil, comfrey extract, collagen, lingonberry extract, Asarum sieboldii extract, Bupleurum chinense extract, umbilical cord extract, saffron extract, sage extract, soapwort extract, bamboo extract, hawthorn extract, sunflower extract Sodium, Japanese pepper extract, shiitake mushroom extract, rehmannia extract, lithospermum extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, ginger extract, calamus root extract, birch extract, white fungus extract, horsetail extract, stevia extract, stevia ferment, iris extract, ivy extract, hawthorn extract, elderflower extract, yarrow extract, peppermint extract, sage extract, mallow extract, chuanxiong extract, swertia japonica extract, mulberry bark extract, rhubarb extract,Soybean extract, jujube extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, cogongrass extract, citrus peel extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, Ophiopogon extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, Isodon japonicus extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur extract, Poria cocos extract, butcher's broom extract, grape extract Examples of extracts include grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, cypress extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, lemon balm extract, seaweed extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, reishi mushroom extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

[0065] The fragrance ingredients include acetylcedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, iso-esuper, isobutylquinoline, iris oil, ylone, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragol, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carbone, camphor, canone, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styraryl acetate, cedyl acetate, terepinel acetate, and pt-butylcyclohexyl acetate. Lu, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanol, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, α-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexyl Cinnamaldehyde, cis-3-Hexenol, Peruvian Balsam, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzoate Preferred examples include synthetic and natural fragrances such as benzoate, borneol, myrrhizinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, liral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances.

[0066] In addition, it is possible to include ingredients listed in the Cosmetic Ingredient Standards, Cosmetic Ingredient Formulation Standards, Japan Cosmetic Industry Association Ingredient Labeling Name List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Ingredient Standards, Japanese Pharmacopoeia, Pharmaceutical Additives Standards, Food Additives Compendium, etc., as well as known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., to the extent that the effects of the present invention can be obtained.

[0067] The initial viscosity of the compositions of this disclosure is not particularly limited and can be adjusted as appropriate depending on the purpose, but is preferably 2000 mPa·s or more, more preferably 5000 mPa·s or more, even more preferably 10000 mPa·s or more, even more preferably 15000 mPa·s or more, and particularly preferably 20000 mPa·s or more. On the other hand, it is preferably 70000 mPa·s or less, more preferably 60000 Pa·s or less, even more preferably 55000 mPa·s or less, even more preferably 50000 mPa·s or less, and particularly preferably 40000 mPa·s or less. Specifically, for example, these ranges are 2000 mPa·s to 70000 mPa·s, 5000 mPa·s to 60000 mPa·s, 10000 mPa·s to 55000 mPa·s, 10000 mPa·s to 50000 mPa·s, 15000 mPa·s to 50000 mPa·s, 20000 mPa·s to 50000 mPa·s, or 20000 mPa·s to 40000 mPa·s.

[0068] In the present invention, the initial viscosity and the viscosity after storage, as described later, can be easily and effectively adjusted without impairing the feel of use by increasing or decreasing the content of sulfated polysaccharides derived from Suizenji-nori. However, viscosity adjustment does not need to be performed solely by sulfated polysaccharides derived from Suizenji-nori; the viscosity adjustment effect of sulfated polysaccharides derived from Suizenji-nori may be used in combination with the viscosity adjustment effect of other components. When adjusting viscosity with other components, this can be done according to well-known and conventional methods, such as adjusting the type and content of other thickeners, or the content and usage ratio of oily components (for example, the ratio of liquid components to solid components). In this specification, "initial viscosity" refers to the viscosity of an oil-in-water emulsion composition immediately after preparation, and is the measured value 30 seconds after the start of measurement, using a digital B-type viscometer ("Digital Viscometer DV2T", manufactured by Eiko Seiki Co., Ltd.) with an LV-4 rotor, under the conditions of a rotation speed of 6 rpm and a measurement temperature of 25°C.

[0069] The viscosity of the oil-in-water emulsion composition after storage is not particularly limited, but is preferably 2000 mPa·s or more, more preferably 5000 mPa·s or more, even more preferably 10000 mPa·s or more, even more preferably 18000 mPa·s or more, even more preferably 20000 mPa·s or more, even more preferably 25000 mPa·s or more, even more preferably 30000 mPa·s or more, and even more preferably 35000 mPa·s or more. On the other hand, it is preferably 70000 mPa·s or less, more preferably 60000 Pa·s or less, even more preferably 55000 mPa·s or less, even more preferably 50000 mPa·s or less, and even more preferably 40000 mPa·s or less. Specifically, for example, these ranges are 2000 mPa·s to 70000 mPa·s, 5000 mPa·s to 60000 mPa·s, 10000 mPa·s to 55000 mPa·s, 18000 mPa·s to 70000 mPa·s, 20000 mPa·s to 60000 mPa·s, 25000 mPa·s to 55000 mPa·s, 30000 mPa·s to 50000 mPa·s, or 35000 mPa·s to 40000 mPa·s. In this specification, "viscosity after storage" refers to the viscosity of the composition disclosed herein after being left standing at 50°C for one month. This is the measurement taken 30 seconds after the start of measurement using a digital B-type viscometer ("Digital Viscometer DV2T," manufactured by Eiko Seiki Co., Ltd.), with the LV-4 rotor, a rotation speed of 6 rpm, and a measurement temperature of 25°C.

[0070] The viscosity retention rate of the oil-in-water emulsion composition is not particularly limited, but is preferably 70% or more, more preferably 75% or more, even more preferably 80% or more, even more preferably 85% or more, and even more preferably 90% or more. Specifically, for example, it is 70% to 100%, 75% to 100%, 80% to 100%, 85% to 100%, or 90% to 100%. By incorporating sulfated polysaccharides derived from Suizenji-nori, an oil-in-water emulsion composition with excellent viscosity (emulsification) stability can be obtained. In this specification, "viscosity retention rate" refers to the ratio (%) of the viscosity after storage (mPa·s) to the initial viscosity (mPa·s).

[0071] The median diameter (d50) of the emulsion particles in an oil-in-water emulsion composition, calculated on a volume-average basis, is not particularly limited, but is preferably 25.0 μm or less, more preferably 20.0 μm or less, even more preferably 15.0 μm or less, even more preferably 10.0 μm or less, even more preferably 5.0 μm or less, and even more preferably 3.0 μm or less. On the other hand, it is preferably 0.5 μm or more, more preferably 1.0 μm or more, and even more preferably 1.2 μm or more. Specifically, for example, it is 0.5 μm to 25.0 μm, 0.5 μm to 20.0 μm, 0.5 μm to 15.0 μm, 1.0 μm to 10.0 μm, 1.0 μm to 5.0 μm, or 1.2 μm to 3.0 μm. In this specification, the median diameter refers to the median diameter calculated on a volume-averaged basis using a laser diffraction particle size distribution analyzer ("SALD-7000", manufactured by Shimadzu Corporation).

[0072] (Cosmetics) The oil-in-water emulsion composition of the present invention can be used as a cosmetic after further addition of necessary components. Examples of necessary components include the optional components mentioned above in the description of the oil-in-water emulsion composition. [Examples]

[0073] The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

[0074] [Example 1, Comparative Example 1] The compositions (creams) of Example 1 and Comparative Example 1 were prepared using the following procedure. First, component A, as shown in Table 1, was dispersed at room temperature and then heated to 80°C and mixed and dissolved. In a separate container, component B was heated to 80°C and mixed and dissolved. Next, component A was gradually added to component B in several batches while stirring with a homomixer at 80°C. After that, the mixture was emulsified by stirring with a homomixer at 7000 rpm for 3 minutes. Then, component C was added while stirring at 80 rpm with the stirring blade changed to a U-shaped blade, and the mixture was air-cooled to below 40°C to obtain the compositions (creams) shown in Table 1. The content of each component listed in Table 1 is in parts by mass. The following evaluations and measurements were performed on each of the obtained oil-in-water emulsion compositions.

[0075] (viscosity measurement) The viscosity (initial viscosity) of each example of oil-in-water emulsion composition was measured using a digital B-type viscometer ("Digital Viscometer DV2T," manufactured by Eiko Seiki Co., Ltd.). The results are shown in Table 1. An LV-04 rotor was used, and measurements were taken at a rotation speed of 6 rpm and a measurement temperature of 25°C. The measured value 30 seconds after the start of measurement was taken as the viscosity.

[0076] (Stability evaluation) After storing each example of an oil-in-water emulsion composition at 50°C for 3 weeks, its viscosity was measured in the same manner as described above and compared with its initial viscosity to confirm its stability after long-term storage. The results are shown in Table 1. A: The viscosity is well maintained at over 90% of the initial viscosity. B: Maintains a viscosity of 80% to 90% of the initial viscosity. C: Viscosity has decreased to less than 80% of the initial viscosity.

[0077] (Evaluation of emulsion particle size) Using a laser diffraction particle size distribution analyzer ("SALD-7000", manufactured by Shimadzu Corporation), the particle size distribution of emulsion particles in each example of oil-in-water emulsion composition was measured as the median diameter (d50) on a volume-average basis and evaluated according to the following criteria. The results are shown in Table 1. A: 3μm or less B: 5μm or less C: More than 5μm

[0078] [Table 1]

[0079] From the above results, it was confirmed that the oil-in-water emulsion composition of Example 1 according to the present invention yields an oil-in-water emulsion composition with appropriate viscosity, and that the oil-in-water emulsion composition containing sulfated polysaccharides derived from Suizenji-nori has appropriately small emulsion particle sizes in the aqueous phase and exhibits high stability despite being an emulsion composition. On the other hand, the oil-in-water emulsion composition of Comparative Example 1, which does not use sulfated polysaccharides derived from Suizenji-nori, had lower viscosity, larger emulsion particle sizes, and inferior product stability compared to the oil-in-water emulsion composition of Example 1. Furthermore, the oil-in-water emulsion composition of Example 1 had superior usability despite having higher viscosity compared to the oil-in-water emulsion composition of Comparative Example 1. Therefore, it was confirmed that an excellent oil-in-water emulsion composition can be obtained by using sulfated polysaccharides derived from Suizenji-nori as a thickening agent.

Claims

1. An oil-in-water emulsion composition containing sulfated polysaccharides derived from Suizenji-nori, an oily component, and an aqueous medium.

2. The oil-in-water emulsion composition according to claim 1, wherein the content of the sulfated polysaccharide derived from Suizenji-nori in the oil-in-water emulsion composition is 0.05% by mass to 0.5% by mass.

3. A cosmetic composition containing the oil-in-water emulsion composition according to claim 1 or 2.

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