Methods and compositions for the diagnosis and treatment of cancer

JP2026517574APending Publication Date: 2026-06-02CHENGDU ANTICANCER BIOSCI LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
CHENGDU ANTICANCER BIOSCI LTD
Filing Date
2024-03-27
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Current anti-mitotic agents for cancer treatment face challenges such as mechanism-related side effects and drug resistance, and targeting MYC oncogene directly can lead to undesirable outcomes, necessitating the development of novel therapies that selectively target cancer cells while minimizing impact on normal dividing cells.

Method used

The use of biomarkers to identify individuals with elevated MYC expression and decreased MKLP2 activity, combined with agents that inhibit mitotic kinases or dysregulate chromosomal passenger protein complexes, to selectively target and inhibit cancer cell viability and proliferation.

Benefits of technology

This approach allows for the precise identification and treatment of cancer cells with high MYC and low MKLP2 expression, enhancing treatment efficacy and minimizing side effects on normal cells, thereby providing a targeted therapy for various cancer types.

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Abstract

The present invention relates to determining the expression or activity levels of specific biomarkers in biological samples, which can be used for the diagnosis, prognosis prediction, and treatment of cancer in individuals, and further to the selection of individuals who will benefit from cancer treatment (e.g., treatment involving one or more agents that inhibit the viability and / or proliferation of cancer cells). Accordingly, the present invention encompasses methods of utilizing these biomarkers for the diagnosis, prognosis prediction, and treatment of cancer, and for screening for compounds that reduce the risk of an individual developing cancer, compounds that reduce the risk of an individual developing one or more symptoms of cancer, and compounds that alleviate one or more symptoms of cancer in an individual. TIFF2026517574000069.tif212152
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