Synthesis of oligonucleotides using cyclic phosphate nucleosides
A method using cyclic phosphate nucleosides and benzyl alcohol nucleophiles in a liquid-phase process efficiently synthesizes oligonucleotides, overcoming scalability and cost issues of existing methods, enabling efficient production of short to long-chain oligonucleotides.
JP2026517877APending Publication Date: 2026-06-02ELI LILLY & CO +1
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- ELI LILLY & CO
- Filing Date
- 2024-05-08
- Publication Date
- 2026-06-02
Smart Images
Figure 2026517877000001_ABST
Abstract
This disclosure provides methods for preparing oligonucleotides. In certain embodiments, this disclosure provides methods for preparing oligonucleotides using cyclic phosphate nucleosides. In certain embodiments, this disclosure provides methods for preparing oligonucleotides using substituted benzyl alcohol nucleophiles. In certain embodiments, this disclosure provides methods for preparing oligonucleotides using cyclic phosphate nucleosides and substituted benzyl alcohol nucleophiles. [Formula 1] TIFF2026517877000241.tif38170
Need to check novelty before this filing date? Find Prior Art