5,6-condensed and 6,6-condensed bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators

Abstract

This disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions in the treatment of 15-hydroxy-prostaglandin dehydrogenase-mediated diseases. Methods for producing such compounds and their intermediates are also provided. The compounds have general formula (A): It has TIFF2026518604000656.tif11170. Furthermore, this disclosure provides intermediates useful for the synthesis of compounds of formula (A).

Claims

1. Formula (A) 【Chemistry 1】 (In the formula, 【Chemistry 2】 teeth, 【Transformation 3】 And, m is either 0 or 1. X is either N or CH, Y is N or C-R ３ And, Z is N or C-R ５ And, b is N or C-R ４ And, R １ａ is -H, deuterium, C １～６ Alkyl or C １～６ It is a haloalkyl, R １ａ is C １～６ alkyl or C １～６ haloalkyl, R １ａ is unsubstituted or is independently substituted with one or more substituents which are halogen, -OH, -N(R ｂ ), ２ C １～３ alkyl or C １～３ alkoxy, R １ｂ is -H, C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Heteroalkyl, -(C １～６ Alkylene)-O-(C) １～６ Alkyl), C ３～１０ A cycloalkyl or heterocyclyl having 3 to 10 ring members, R １ｂ C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Heteroalkyl, -(C １～６ Alkylene)-O-(C) １～６ Alkyl), C ３～１０ If it is a cycloalkyl or a heterocyclyl having 3 to 10 ring members, R １ｂ These are either unsubstituted or each independently a halogen, -OH, and -N(R) ｂ ) ２ , C １～３ Alkyl or C １～３ The C may be substituted with one or more substituents that are alkoxy. １～３ Alkyl and C １～３ Each alkoxy is either unsubstituted or can be substituted with 1 to 6 -F groups, or Instead, R １ａ and R １ｂ C ３～１０ Cycloalkyl, C ３～１０ They together form cycloalkenyls or heterocyclyls having 3 to 10 ring members, The aforementioned R １ａ and R １ｂ The rings are either unsubstituted or each independently consists of a halogen, -OH, oxo, and -N(R). ｂ ) ２ , C １～３ Alkyl, C １～３ Alkoxy, -CN, C １～６ Heteroalkyl, C ３～１０ The C may be substituted with one or more substituents that are cycloalkyl or heterocyclyl having 3 to 10 ring members. １～３ Alkyl and C １～３ Each alkoxy is either unsubstituted or has 1 to 9 halogen groups or C １～３ It may be substituted with an alkoxy. R １ｃ is -H, C １～６ Alkyl or C ３～６ It is a cycloalkyl, R １ｃ C １～６ Alkyl or C ３～６ If it is a cycloalkyl, R １ｃ These are either unsubstituted or each independently a halogen, -OH, and -N(R) ｂ ) ２ , C １～３ Alkyl, C １～３ Alkoxy or C １～６ It may be substituted with one or more substituents that are heteroalkyl. R ２ C ３～２０ Cycloalkyl, C ３～２０ Cycloalkenyl, C ６～１８ The aryl, heteroaryl having 5 to 20 ring members, or heterocyclyl having 3 to 20 ring members, R ２ These are either unsubstituted or each independently a halogen, -OH, oxo, and -N(R) ｂ ) ２ , C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkoxy, C １～６ Alkylene-OH, C １～６ Alkylene-OC １～６ Alkyl or C １～６ It may be substituted with one or more substituents that are heteroalkyl. R ３ is -H, C １～６ Alkyl, C １～６ Haloalkyl, C ３～６ Cycloalkyl, amino, C １～４ Alkyl-amino, di-C １～４ Alkyl-amino, C ６～１０ The aryl, the heteroaryl having 5 to 10 ring members, or the heterocyclyl having 5 to 10 ring members, R ３ is C １～６ alkyl, C １～６ haloalkyl, C ３～６ cycloalkyl, C １～４ alkyl - amino, di - C １～４ alkyl - amino, C ６～１０ aryl, heteroaryl having 5 to 10 ring members or heterocyclyl having 5 to 10 ring members, then R ３ is unsubstituted or is independently substituted with one or more substituents which are halogen, - OH, oxo, - N(R ｂ ), ２ C １～３ alkyl, C １～３ haloalkyl, C １～３ alkoxy, C １～３ alkylene - C １～３ alkoxy, C １～６ heteroalkyl, or two R ３ substituents together form a carbocyclic or heterocyclic having 3 to 6 ring members,​​ R ４ is -H, C １～３ Alkyl, C １～３ Haloalkyl, -CN, halogen or -N(R) ａ ) ２ And R ａ Each example, if present, independently of -H, C １～６ Alkyl or -C(O)C １～６ It is alkyl, or instead, it has two R's. ａ The substituents together form a heterocyclyl having 3 to 6 ring members. R ａ These are either unsubstituted or each is independently -F, -Cl, -OH, C １～３ It may be substituted with one or more substituents that are alkoxy. R ５ is -H, C １～６ Alkyl, C ３～６ Cycloalkyl, C １～６ Haloalkyl or C １～６ It is heteroalkyl, R ５ C １～６ Alkyl, C ３～６ Cycloalkyl, C １～６ Haloalkyl or C １～６ If it is a heteroalkyl, R ５ These are either unsubstituted or each is independently a halogen, -OH, or C １～３ Alkyl or C １～３ It may be substituted with one or more substituents that are alkoxy. R ｂ Each example, if present, independently of -H or C １～６ It is alkyl, or instead, it has two R's. ｂ The substituents together form a heterocyclyl having 3 to 6 ring members. R ｂ C １～６ It is alkyl, or instead, it has two R's. ｂ When the substituents together form a heterocycline having 3 to 6 ring members, R ｂ These are either unsubstituted or each is independently -F, -Cl, -OH, C １～３ It may be substituted with one or more substituents that are alkoxy. however, a) 【Chemistry 4】 but, 【Transformation 5】 If R ３ This is not unsubstituted or substituted morpholinyl, and b) 【Transformation 6】 but, 【Transformation 7】 If R １ａ and R １ｂ Both are not methyl, R １ａ and R １ｂ Both are -CF ３ It is not the case that R １ｂ If R is methyl, １ａ -CF ３ No, RI １ａ If R is methyl, １ｂ -CF ３ Rather, and R １ａ and R １ｂ (This does not provide unsubstituted or substituted piperdinyl.) A compound of the said compound or a pharmaceutically acceptable salt of the said compound. 【Request Item 2】 【Chemistry 8】 teeth, 【Chemistry 9】 The compound or salt according to claim 1. 【Request Item 3】 【Chemistry 10】 teeth, 【Chemistry 11】 The compound or salt according to claim 1 or 2. 【Request Item 4】 【Chemistry 12】 teeth, 【Chemistry 13】 The compound or salt according to any one of claims 1 to 3. 【Request Item 5】 【Chemistry 14】 teeth, 【Chemistry 15】 The compound or salt according to any one of claims 1 to 4.

6. The compound of formula (A) is of formula (I) 【Chemistry 16】 (In the formula, X is either N or CH, R １ａ is -H, C １～６ Alkyl or C １～６ It is a haloalkyl, R １ａ C １～６ Alkyl or C １～６ If R is a haloalkyl, １ａ These are either unsubstituted or each independently a halogen, -OH, and -N(R) ｂ ) ２ , C １～３ Alkyl or C １～３ It may be substituted with one or more substituents that are alkoxy. R １ｂ is -H, C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Heteroalkyl, -(C １～６ Alkylene)-O-(C) １～６ Alkyl), C ３～１０ A cycloalkyl or heterocyclyl having 3 to 10 ring members, R １ｂ C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Heteroalkyl, C ３～１０ If it is a cycloalkyl or a heterocyclyl having 3 to 10 ring members, R １ｂ These are either unsubstituted or each independently a halogen, -OH, and -N(R) ｂ ) ２ , C １～３ Alkyl or C １～３ The C may be substituted with one or more substituents that are alkoxy. １～３ Alkyl and C １～３ Each alkoxy is either unsubstituted or can be substituted with 1 to 6 -F groups, or Instead, R １ａ and R １ｂ C ３～１０ Cycloalkyl, C ３～１０ They together form cycloalkenyls or heterocyclyls having 3 to 10 ring members, The aforementioned R １ａ and R １ｂ The rings are either unsubstituted or each independently consists of a halogen, -OH, oxo, and -N(R). ｂ ) ２ , C １～３ Alkyl, C １～３ Alkoxy or C １～６ The C may be substituted with one or more substituents that are heteroalkyl. １～３ Alkyl and C １～３ Each alkoxy is either unsubstituted or has 1 to 9 halogen groups or C １～３ It may be substituted with an alkoxy. R １ｃ is -H, C １～６ Alkyl or C ３～６ It is a cycloalkyl, R １ｃ C １～６ Alkyl or C ３～６ If it is a cycloalkyl, R １ｃ These are either unsubstituted or each independently a halogen, -OH, and -N(R) ｂ ) ２ , C １～３ Alkyl, C １～３ Alkoxy or C １～６ It may be substituted with one or more substituents that are heteroalkyl. R ２ C ３～２０ Cycloalkyl, C ３～２０ Cycloalkenyl, C ６～１８ The aryl, heteroaryl having 5 to 20 ring members, or heterocyclyl having 3 to 20 ring members, R ２ These are either unsubstituted or each independently a halogen, -OH, oxo, and -N(R) ｂ ) ２ , C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkoxy, C １～６ Alkylene-OH, C １～６ Alkylene-OC １～６ Alkyl or C １～６ It may be substituted with one or more substituents that are heteroalkyl. R ３ is -H, C １～６ Alkyl, C １～６ Haloalkyl, C ３～６ Cycloalkyl, amino, C １～４ Alkyl-amino, di-C １～４ Alkyl-amino, C ６～１０ The aryl, the heteroaryl having 5 to 10 ring members, or the heterocyclyl having 5 to 10 ring members, R ３ C １～６ Alkyl, C １～６ Haloalkyl, C ３～６ Cycloalkyl, C １～４ Alkyl-amino, di-C １～４ Alkyl-amino, C ６～１０ In the case of an aryl, a heteroaryl having 5 to 10 ring members, or a heterocyclyl having 5 to 10 ring members, R ３ These are either unsubstituted or each independently a halogen, -OH, oxo, and -N(R) ｂ ) ２ , C １～３ Alkyl, C １～３ Haloalkyl, C １～３ Alkoxy, C １～３ Alkylene-C １～３ Alkoxy, C １～６ It may be substituted with one or more substituents that are heteroalkyl, or with two R ３ The substituent is C ３～６ Carbocyclils or heterocyclils having 3 to 6 ring members are formed together. R ４ is -H or -N (R ａ ) ２ And R ａ Each example, if present, independently of -H or C １～６ It is alkyl, or instead, it has two R's. ａ The substituents together form a heterocyclyl having 3 to 6 ring members. R ａ These are either unsubstituted or each is independently -F, -Cl, -OH, C １～３ It may be substituted with one or more substituents that are alkoxy. R ５ is -H, C １～６ Alkyl, C ３～６ Cycloalkyl, C １～６ Haloalkyl or C １～６ It is heteroalkyl, R ５ C １～６ Alkyl, C ３～６ Cycloalkyl, C １～６ Haloalkyl or C １～６ If it is a heteroalkyl, R ５ These are either unsubstituted or each is independently a halogen, -OH, or C １～３ Alkyl or C １～３ It may be substituted with one or more substituents that are alkoxy. R ｂ Each example, if present, independently of -H or C １～６ It is alkyl, or instead, it has two R's. ｂ The substituents together form a heterocyclyl having 3 to 6 ring members. R ｂ C １～６ It is alkyl, or instead, it has two R's. ｂ When the substituents together form a heterocycline having 3 to 6 ring members, R ｂ These are either unsubstituted or each is independently -F, -Cl, -OH, C １～３ (May be substituted with one or more substituents that are alkoxy) A compound of the said compound or a pharmaceutically acceptable salt of the said compound, However, the aforementioned compound is 6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-methanol, 6-Cyclopropylbenzo[b]thiophene-2-methanol, 6-phenylbenzo[b]thiophene-2-methanol, or 6-[3-[(dimethylamino)methyl]bicyclo[2.2.1]hepta-2-en-2-yl]benzo[b]thiophene-2-methanol The compound described in any one of claims 1 to 5, not the compound described in any one of claims 1 to 5.

7. A compound or salt according to any one of claims 1 to 6, wherein X is N.

8. The compound or salt according to any one of claims 1 to 7, wherein X is CH.

9. R １ａ C is -H, unsubstituted or substituted. １～３ Alkyl or unsubstituted or substituted C １～３ A compound or salt according to any one of claims 1 to 8, which is a haloalkyl compound.

10. R １ａ The compound or salt according to any one of claims 1 to 9, wherein is substituted with one, two, three, or four substituents.

11. R １ａ If replaced, each R １ａ The substituents are independently -F, -OH, or C １～３ A compound or salt according to any one of claims 1 to 10, which is an alkoxy.

12. R １ａ The compound or salt according to any one of claims 1 to 9, wherein the compound is unsubstituted.

13. R １ａ is -H, -CH ３ or -CF ３ The compound or salt according to any one of claims 1 to 9.

14. R １ｂ C is -H, unsubstituted or substituted. １～３ Alkyl, unsubstituted, or substituted C １～３ Haloalkyl, unsubstituted, or substituted C ３～６ The compound or salt according to any one of claims 1 to 13, which is a cycloalkyl or an unsubstituted or substituted heterocycline having 3 to 6 ring members.

15. R １ｂ The compound or salt according to any one of claims 1 to 14, wherein is an unsubstituted or substituted cycloalkyl spiro ring system or an unsubstituted or substituted heterocyclyl spiro ring system.

16. R １ｂ The compound or salt according to any one of claims 1 to 15, wherein the compound is a bicyclic ring system.

17. R １ｂ These are nitrogen, oxygen, or -S(O) respectively, independently. ｘ A compound or salt according to any one of claims 1 to 16, having 1, 2, or 3 heteroatom ring members, wherein x is 0, 1, or 2.

18. R １ｂ The compound or salt according to any one of claims 1 to 17, wherein is an unsubstituted or substituted heterocyclyl having one, two or three heteroatom ring members, each independently being nitrogen or oxygen.

19. R １ｂ The compound or salt according to any one of claims 1 to 18, wherein is an unsubstituted or substituted heterocyclyl having 3 to 6 ring members.

20. R １ｂ The compound or salt according to any one of claims 1 to 19, wherein is substituted with one or two substituents.

21. R １ｂ If replaced, each R １ｂ The substituents can be halogens, unsubstituted or substituted carbon atoms, independently. １～３ Alkyl or unsubstituted or substituted C １～３ A compound or salt according to any one of claims 1 to 20, which is an alkoxy.

22. R １ｂ If replaced, each R １ｂ The compound or salt according to any one of claims 1 to 21, wherein the substituent is independently -F, -OH, methyl, or -OMe.

23. R １ｂ The compound or salt according to any one of claims 1 to 19, wherein the compound is unsubstituted.

24. R １ａ and R １ｂ is non-substituted or substituted C ３～１０ A compound or salt according to any one of claims 1 to 8, which together forms a cycloalkyl or an unsubstituted or substituted 3 to 10-membered heterocycline.

25. R １ａ and R １ｂ The compound or salt according to any one of claims 1 to 8 or 24, wherein the compound together forms an unsubstituted or substituted 3 to 10 membered heterocycline.

26. R １ａ and R １ｂ When they form unsubstituted or substituted heterocyclines together, each heterocycline independently contains nitrogen, oxygen, or -S(O) ｘ A compound or salt according to any one of claims 1 to 8 or 24 or 25, comprising one, two or three heteroatom ring members, wherein x is 0, 1 or 2.

27. R １ａ and R １ｂ C is either non-substituted or substituted. ３～１０ A compound or salt according to any one of claims 1 to 8 or 24 to 26, which together forms a cycloalkyl group.

28. R １ａ and R １ｂ The compound or salt according to any one of claims 1 to 8 or 24 to 27, which together form a spiro ring system.

29. R １ａ and R １ｂ The compound or salt according to any one of claims 1 to 8 or 24 to 28, which together form a bicyclic ring system.

30. R １ａ and R １ｂ The compound or salt according to any one of claims 1 to 8 or 24 to 29, wherein the compound or salt together forms a ring substituted with one, two, or three substituents.

31. R １ａ and R １ｂ is, -(C １～３ Alkylene)-O-(C) １～３ A compound or salt according to any one of claims 1 to 8 or 24 to 30, which together forms a ring substituted with alkyl.

32. R １ａ and R １ｂ The substituted rings together form a ring, and each substituent of the ring is independently a halogen, -OH, oxo, -N(R) ｂ ) ２ , C １～３ Alkyl or C １～３ It is an alkoxy, and the C １～３ Alkyl and C １～３ Each alkoxy is either unsubstituted or has 1 to 6 halogen groups or C １～３ A compound or salt according to any one of claims 1 to 8 or 24 to 31, which may be substituted with an alkoxy.

33. R １ａ and R １ｂ The substituted rings together form a ring, and each substituent of the ring is independently -F, -OH, oxo, methyl, methoxy, or -OCF ３ The compound or salt according to any one of claims 1 to 8 or 24 to 32.

34. R １ａ and R １ｂ The compound or salt according to any one of claims 1 to 8 or 24 to 29, wherein the unsubstituted rings are formed together.

35. R １ｃ The compound or salt according to any one of claims 1 to 34, wherein is -H.

36. R １ｃ -CF ３ The compound or salt according to any one of claims 1 to 34.

37. R １ｃ The compound or salt according to any one of claims 1 to 34, wherein is methyl.

38. R ２ is non-substituted or substituted C ３～６ Cycloalkyl, unsubstituted, or substituted C ６～１０ A compound or salt according to any one of claims 1 to 37, which is an aryl, an unsubstituted or substituted heteroaryl, or an unsubstituted or substituted heterocycline.

39. R ２ is an unsubstituted or substituted heteroaryl or an unsubstituted or substituted heterocycline, and the R ２ The compound or salt according to any one of claims 1 to 38, wherein the heteroaryl or heterocyclyl comprises one, two, three, or four heteroatom ring members.

40. R ２ is an unsubstituted or substituted heteroaryl or an unsubstituted or substituted heterocycline, and the R ２ Each ring member heteroatom of the ring is independently nitrogen, oxygen, or -S(O) ｙ The compound or salt according to any one of claims 1 to 39, wherein y is 0, 1, or 2.

41. R ２ The compound or salt according to any one of claims 1 to 40, wherein is an unsubstituted or substituted condensed bicyclic heteroaryl or an unsubstituted or substituted condensed bicyclic heterocyclil.

42. R ２ The compound or salt according to any one of claims 1 to 41, wherein is an unsubstituted or substituted heteroaryl having 8 to 10 ring members or an unsubstituted or substituted heterocyclyl having 8 to 10 ring members.

43. R ２ The compound or salt according to any one of claims 1 to 42, wherein is an unsubstituted or substituted heteroaryl compound.

44. R ２ The compound or salt according to any one of claims 1 to 43, wherein is substituted with one, two, or three substituents.

45. R ２ If replaced, each R ２ The substituents are, independently, halogen, -OH, oxo, and C. １～３ Alkyl or C １～３ A compound or salt according to any one of claims 1 to 44, which is an alkoxy.

46. R ２ If replaced, each R ２ The compound or salt according to any one of claims 1 to 45, wherein the substituent is independently methyl, ethyl, or isopropyl.

47. R ２ The compound or salt according to any one of claims 1 to 44, wherein the compound is unsubstituted.

48. R ２ teeth, 【Chemistry 17】 And, 「 [Chemistry 18] This indicates that a double bond or a single bond may be present. X ａ Each of these examples is, independently, nitrogen, oxygen, or carbon. Each example of n is an integer selected from 1, 2, 3, 4, or 5, if any exist. Each example of n' is an integer selected from 1, 2, 3, 4, or 5, if any exist. Each example of p is an integer selected from 0, 1, 2, 3, or 4, if present. Each example of r, if present, is an integer selected from 0, 1, 2, 3, 4, or 5, and two examples of r are the same R ２ If present on the base, the sum of both combined r values ​​does not exceed 5. R １２ Each example exists and, if bonded to an N-member, C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkylene-OH or C １～６ Alkylene-OC １～６ It is alkyl, and R １２ Each example, when present and bonded to a C ring member, is independently halogen, -OH, oxo, -N(R) ｂ ) ２ , C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkoxy, C １～６ Alkylene-OH or C １～６ Alkylene-OC １～６ A compound or salt according to any one of claims 1 to 47, wherein the compound is alkyl.

49. R ２ teeth, 【Chemistry 19】 The compound or salt according to any one of claims 1 to 37.

50. R ２ teeth, 【Chemistry 20】 The compound or salt according to any one of claims 1 to 37.

51. R ３ is non-substituted or substituted C ３～６ Cycloalkyl, unsubstituted, or substituted C ３～１０ Cycloalkenyl, unsubstituted or substituted C ６～１０ The compound or salt according to any one of claims 1 to 50, wherein the compound is an aryl, an unsubstituted or substituted heteroaryl having 5 to 10 ring members, or an unsubstituted or substituted heterocyclyl having 5 to 10 ring members.

52. R ３ is an unsubstituted or substituted heteroaryl or an unsubstituted or substituted heterocycline, and the R ３ The compound or salt according to any one of claims 1 to 51, wherein the heteroaryl or heterocyclyl comprises one, two, three, or four heteroatom ring members.

53. R ３ is an unsubstituted or substituted heteroaryl or an unsubstituted or substituted heterocycline, and the R ３ Each heteroatom in the ring is independently nitrogen, oxygen, or -S(O) ｚ The compound or salt according to any one of claims 1 to 52, wherein z is - and z is 0, 1 or 2.

54. R ３ The compound or salt according to any one of claims 1 to 53, wherein is an unsubstituted or substituted heteroaryl compound.

55. R ３ C is either non-substituted or substituted. ３～４ A compound or salt according to any one of claims 1 to 51, which is a cycloalkyl compound.

56. R ３ C is either non-substituted or substituted. １～６ A compound or salt according to any one of claims 1 to 51, wherein the compound is alkyl.

57. R ３ The compound or salt according to any one of claims 1 to 56, wherein is substituted with one, two, or three substituents.

58. R ３ If replaced, each R ３ The substituents are independently C １～３ Alkyl, C １～３ Alkoxy or C １～３ Alkylene-C １～３ A compound or salt according to any one of claims 1 to 57, which is an alkoxy.

59. R ３ The compound or salt according to any one of claims 1 to 56, wherein the compound is unsubstituted.

60. R ３ The compound or salt according to any one of claims 1 to 50, wherein is -H.

61. R ４ is -H, C １～３ Alkyl, halogen, or -N(R) ａ ) ２ And R ａ Each example, if present, independently of -H or C １～６ A compound or salt according to any one of claims 1 to 60, which is alkyl.

62. R ４ is -N(R ａ ) ２ The compound or salt according to any one of claims 1 to 61.

63. R ４ The compound or salt according to any one of claims 1 to 61, wherein is methyl.

64. R ４ The compound or salt according to any one of claims 1 to 61, wherein is -H.

65. R ５ is -H or unsubstituted or substituted C １～６ A compound or salt according to any one of claims 1 to 64, wherein the compound is alkyl.

66. R ５ The compound or salt according to any one of claims 1 to 65, wherein is -H.

67. The aforementioned compound, 5-(4-cyclobutyl-2-(methoxymethyl)thieno[2,3-b]pyridine-6-yl)-2-methyl-2H-pyrazolo[3,4-b]pyridine, 5-(2-(methoxymethyl)-4-(1-(methoxymethyl)cyclobutyl)thieno[2,3-b]pyridine-6-yl)-2-methyl-2H-pyrazolo[3,4-b]pyridine, (R)-(4,6-bis(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)(cyclobutyl)methanol, (S)-(4,6-bis(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)(cyclobutyl)methanol, (R)-Cyclobutyl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-Cyclobutyl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-Cyclobutyl(4-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-6-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-Cyclobutyl(4-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-6-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, 5-(2-((R)-cyclobutyl(methoxy)methyl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-6-yl)-2-methyl-2H-pyrazolo[3,4-b]pyridine, 5-(2-((S)-cyclobutyl(methoxy)methyl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-6-yl)-2-methyl-2H-pyrazolo[3,4-b]pyridine, (1R)-1-cyclobutyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-cyclobutyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1R)-1-cyclobutyl-2,2,2-trifluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-cyclobutyl-2,2,2-trifluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1R)-1-(4-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-6-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-(4-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-6-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1R)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-4-(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (R)-Cyclobutyl(6-Cyclopropyl-4-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-Cyclobutyl(6-Cyclopropyl-4-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-Cyclobutyl(4-Cyclopropyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-Cyclobutyl(4-Cyclopropyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (4-(dimethylamino)-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2,5-diyl)diethanol, (1R)-1-(4,6-bis(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-(4,6-bis(1-methyl-1H-pyrazole-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1R)-1-(4,6-bis(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)ethanol, (1S)-1-(4,6-bis(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)ethanol, (1R)-1-(4-cyclopropyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-(4-cyclopropyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1R)-1-(6-cyclopropyl-4-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-(6-cyclopropyl-4-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1R)-1-(4-cyclopropyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-propanol, (1S)-1-(4-cyclopropyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-propanol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-Cyclopropyl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-Cyclopropyl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-Cyclobutyl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-Cyclobutyl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (3R)-3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)tetrahydro-3-furanol, (3S)-3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)tetrahydro-3-furanol, 1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 4-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)tetrahydro-2H-pyran-4-ol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((3R)-tetrahydro-3-furanyl)methanol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((3S)-tetrahydro-3-furanyl)methanol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((3R)-tetrahydro-3-furanyl)methanol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)((3S)-tetrahydro-3-furanyl)methanol, 3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-3-oxetanol, 1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclopentanol, (1R)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-propanol, (1S)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-propanol, (6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (1R)-2,2,2-trifluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-2,2,2-trifluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1R)-2-methyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-propanol, (1S)-2-methyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-propanol, (1R)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1R)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-butanol, (1S)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-butanol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)(3-oxetanyl)methanol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(3-oxetanyl)methanol, (1R)-3-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-propanol, (1S)-3-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-1-propanol, 4,4-difluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclohexanol, (2R)-1,1,1-trifluoro-3-methoxy-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-propanol, (2S)-1,1,1-trifluoro-3-methoxy-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-propanol, (1R)-1-cyclopropyl-2,2,2-trifluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-cyclopropyl-2,2,2-trifluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (R)-(3,3-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(4,4-difluorocyclohexyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-(4,4-difluorocyclohexyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, 1-methyl-3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3-azetidinol, (3R)-1-methyl-3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3-piperidinol, (3S)-1-methyl-3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3-piperidinol, (2R)-1,1,1-trifluoro-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-butanol, (2S)-1,1,1-trifluoro-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-butanol, (1R)-2-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-2-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, 4-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)tetrahydro-2H-thiopyran-4-ol 1,1-dioxide, 2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-2-propanol, (2R)-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-butanol, (2S)-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-2-butanol, (1R)-1-cyclopropyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (1S)-1-cyclopropyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, 1-methyl-4-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-4-piperidinol, (2R)-1-methoxy-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-propanol, (2S)-1-methoxy-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-2-propanol, 3,3-difluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (3R)-1-methyl-3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3-pyrrolidinol, (3S)-1-methyl-3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3-pyrrolidinol, (R)-(1-methyl-4-piperidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-(1-methyl-4-piperidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-(6-(1-methyl-1H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(6-(1-methyl-1H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-(6-(1-methyl-1H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(6-(1-methyl-1H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (2R)-1,1,1-trifluoro-4-methoxy-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-butanol, (2S)-1,1,1-trifluoro-4-methoxy-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-butanol, (S)-(6-(1H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(6-(1H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-(6-(6-methyl-1H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(6-(6-methyl-1H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (2R)-1,1,1-trifluoro-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-propanol, (2S)-1,1,1-trifluoro-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-propanol, (S)-(6-(2-methyl-2H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(6-(2-methyl-2H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-(6-(3-methyl-1H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(6-(3-methyl-1H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (2R)-4-methoxy-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-2-butanol, (2S)-4-methoxy-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-2-butanol, (R)-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(1-methyl-3-azetidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-(1-methyl-3-azetidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-(6-(1,2-benzoxazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(6-(1,2-benzoxazole-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-tetrahydro-2H-pyran-4-yl(6-(3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-tetrahydro-2H-pyran-4-yl(6-(3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-((2R)-1-methyl-2-azetidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (R)-((2S)-1-methyl-2-azetidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-((2R)-1-methyl-2-azetidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-((2S)-1-methyl-2-azetidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(2-methyl-1,3-benzoxazole-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(2-methyl-1,3-benzoxazole-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(1H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(1H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(2-methylimidazo[1,2-a]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(2-methylimidazo[1,2-a]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)methanol, 6-(2-((R)-(3,3-difluorocyclobutyl)(hydroxy)methyl)thieno[2,3-b]pyridine-6-yl)-3-methyl-4(3H)-pyrimidinone, 6-(2-((S)-(3,3-difluorocyclobutyl)(hydroxy)methyl)thieno[2,3-b]pyridine-6-yl)-3-methyl-4(3H)-pyrimidinone, 6-(2-((S)-(3,3-difluorocyclobutyl)(hydroxy)methyl)thieno[2,3-b]pyridine-6-yl)-2-methyl-1(2H)-isoquinolinone, 6-(2-((R)-(3,3-difluorocyclobutyl)(hydroxy)methyl)thieno[2,3-b]pyridine-6-yl)-2-methyl-1(2H)-isoquinolinone, (S)-(3,3-difluorocyclobutyl)(6-(2-methyl-1,3-benzoxazole-6-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(2-methyl-1,3-benzoxazole-6-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(6-quinoxalinyl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(6-quinoxalinyl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(2-ethyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(2-ethyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (1S)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)-1-butanol, (1R)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)-1-butanol, (S)-(3,3-difluorocyclobutyl)(6-(2-methylimidazo[1,2-a]pyridine-7-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(2-methylimidazo[1,2-a]pyridine-7-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(2-(2-propanyl)-2H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(2-(2-propanyl)-2H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(5-pyrimidinyl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(5-pyrimidinyl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-Cyclopentyl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)methanol, (R)-Cyclopentyl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)methanol, (1S)-3-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)-1-propanol, (1R)-3-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)-1-propanol, (1S)-4,4,4-trifluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)-1-butanol, (1R)-4,4,4-trifluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)-1-butanol, (S)-(3,3-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)methanol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((3R)-1-methyl-3-pyrrolidinyl)methanol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((3S)-1-methyl-3-pyrrolidinyl)methanol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((3R)-1-methyl-3-pyrrolidinyl)methanol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((3S)-1-methyl-3-pyrrolidinyl)methanol, (R)-((3R)-1-methyl-3-piperidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (R)-((3S)-1-methyl-3-piperidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-((3R)-1-methyl-3-piperidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-((3S)-1-methyl-3-piperidinyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(2-(2-propanyl)-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(2-(2-propanyl)-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(1-(2-propanyl)-1H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(1-(2-propanyl)-1H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methane-d-ol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methane-d-ol, (R)-(3-amino-6-(5-pyrimidinyl)thieno[2,3-b]pyridine-2-yl)(3,3-difluorocyclobutyl)methanol, (S)-(3-amino-6-(5-pyrimidinyl)thieno[2,3-b]pyridine-2-yl)(3,3-difluorocyclobutyl)methanol, 2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)spiro[3.3]heptan-2-ol, 3,3-dimethyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 6,6-difluoro-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)spiro[3.3]heptan-2-ol, 6-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-2-oxaspiro[3,3]heptan-6-ol, cis-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-3-(trifluoromethyl)cyclobutanol, cis-3-(difluoromethyl)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, cis-3-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (S)-(3,3-difluorocyclobutyl)(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)methanol, 1-(6-(2-ethyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3,3-difluorocyclobutanol, (S)-(3,3-difluorocyclobutyl)(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[3,2-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[3,2-b]pyridine-2-yl)methanol, 3,3-difluoro-1-(6-(3-methyl-3H-imidazo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 3,3-difluoro-1-(6-(2-methyl[1,3]oxazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 3,3-difluoro-1-(6-(2-methyl-3H-imidazo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 3,3-difluoro-1-(6-(1H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 3,3-difluoro-1-(6-(2-methylimidazo[1,2-a]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 1-(6-(2-amino-5-pyrimidinyl)thieno[2,3-b]pyridin-2-yl)-3,3-difluorocyclobutanol, (S)-(3,3-difluorocyclobutyl)(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[4,5-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[4,5-b]pyridine-2-yl)methanol, 3,3-difluoro-1-(6-(2-methyl-1,3-benzoxazole-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, trans-3-fluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (R)-(3,3-difluorocyclobutyl)(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)methanol, (S)-(3,3-difluorocyclobutyl)(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)methanol, (S)-(3-chloro-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(3,3-difluorocyclobutyl)methanol, (R)-(3-chloro-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(3,3-difluorocyclobutyl)methanol, 3,3-difluoro-1-(6-(3H-imidazo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 3,3-difluoro-1-(6-(1H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (R)-(3,3-difluorocyclobutyl)(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[3,2-b]pyridine-2-yl)methanol, (R)-(3,3-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[3,2-b]pyridine-2-yl)methanol, 3,3-difluoro-1-(6-(2-(methylamino)-5-pyrimidinyl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (R)-(3,3-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methane-d-ol, (S)-(3,3-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methane-d-ol, 3,3-difluoro-1-(6-(2-methylimidazo[1,2-a]pyridine-7-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 3,3-difluoro-1-(6-(2-methylimidazo[1,2-a]pyrimidine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (2R)-2-(3,3-difluorocyclobutyl)-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (2S)-2-(3,3-difluorocyclobutyl)-2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, 3,3-difluoro-1-(6-(5-pyrimidinyl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 3,3-difluoro-1-(6-(pyrido[2,3-b]pyrazine-7-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (S)-(3,3-difluorocyclobutyl)(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-7-quinolinyl)methanol, (R)-(3,3-difluorocyclobutyl)(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-7-quinolinyl)methanol, 3,3-difluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-1-benzothiophen-2-yl)cyclobutanol, 3,3-difluoro-1-(6-(2-methyl-2H-indazole-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 1-(6-(1,2-benzoxazole-5-yl)thieno[2,3-b]pyridine-2-yl)-3,3-difluorocyclobutanol, 3,3-difluoro-1-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)spiro[3.5]nonan-2-ol, 2-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)spiro[3,4]octan-2-ol, 3,3-difluoro-1-(6-(2-methylimidazo[1,2-b]pyridazin-7-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 3,3-difluoro-1-(6-(3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (R)-(3,3-difluorocyclobutyl)(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)methanol, trans-6-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-1-oxaspiro[3.3]heptan-6-ol, cis-6-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-1-oxaspiro[3,3]heptan-6-ol, 3,3-dimethyl-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, cis-3-(methoxymethyl)-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, trans-3-methoxy-3-methyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, cis-3-methoxy-3-methyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (R)-(3,3-difluorocyclobutyl)(3-methyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluorocyclobutyl)(3-methyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, 1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)cyclopropanol, 5-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)spiro[2,3]hexane-5-ol, cis-3-cyclopropyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, trans-3-hydroxy-1-methyl-3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanecarbonitriel, cis-3-hydroxy-1-methyl-3-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanecarbonitol, (1S,2R)-2-methyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (1R,2S)-2-methyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (1S)-2,2-dimethyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (1R)-2,2-dimethyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, trans-3-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3-(trifluoromethyl)cyclobutanol, cis-3-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-3-(trifluoromethyl)cyclobutanol, cis-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-3-(trifluoromethoxy)cyclobutanol, 3,3-dimethyl-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)cyclobutanol, cis-1-(3-chloro-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3-methoxycyclobutanol, (1R,2R)-2-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (1R,2S)-2-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (1S,2R)-2-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, cis-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, (1S,2S)-2-methoxy-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, 1-(3-chloro-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3,3-dimethylcyclobutanol, cis-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)[1,3]thiazolo[5,4-b]pyridin-2-yl)-3-(trifluoromethyl)cyclobutanol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((cis)-3-(trifluoromethyl)cyclobutyl)methanol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((cis)-3-(trifluoromethyl)cyclobutyl)methanol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((trans)-3-(trifluoromethyl)cyclobutyl)methanol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)((trans)-3-(trifluoromethyl)cyclobutyl)methanol, cis-1-(3-chloro-6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-3-(trifluoromethyl)cyclobutanol, (R)-((1R)-2,2-difluorocyclopropyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-((1S)-2,2-difluorocyclopropyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-((1R)-2,2-difluorocyclopropyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-((1S)-2,2-difluorocyclopropyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-(3,3-difluoro-1-methylcyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-(3,3-difluoro-1-methylcyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-Bicyclo[1.1.1]pentan-1-yl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-Bicyclo[1.1.1]pentan-1-yl(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-((cis)-3-methoxycyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, cis-3-(difluoromethyl)-1-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (R)-((cis)-3-methoxycyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-((trans)-3-methoxycyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-((trans)-3-methoxycyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, 3,3-dimethyl-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-7-quinolinyl)cyclobutanol, 3,3-difluoro-1-(3-methyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, cis-1-(3-methyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-3-(trifluoromethyl)cyclobutanol, cis-1-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)-3-(trifluoromethyl)cyclobutanol, cis-3-(difluoromethyl)-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, (R)-(2-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)-7-quinolinyl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-(2-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)-7-quinolinyl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-7-quinolinyl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-7-quinolinyl)(tetrahydro-2H-pyran-4-yl)methanol, cis-3-(difluoromethyl)-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)cyclobutanol, cis-3-(difluoromethyl)-1-(5-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)cyclobutanol, (R)-(3-methyl-6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-(3-methyl-6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (R)-(3-methyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, (S)-(3-methyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(tetrahydro-2H-pyran-4-yl)methanol, cis-3-(difluoromethyl)-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-7-quinolinyl)cyclobutanol, (R)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)methanol, (S)-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)methanol, cis-3-fluoro-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, cis-3-(difluoromethyl)-1-(3-methyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, cis-3-(difluoromethyl)-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-6-quinolinyl)cyclobutanol, cis-3-(difluoromethyl)-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[3,2-b]pyridine-2-yl)cyclobutanol, cis-3-(difluoromethyl)-1-(2-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, cis-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[3,2-b]pyridin-2-yl)-3-(trifluoromethyl)cyclobutanol, (S)-(3,3-difluorocyclobutyl)(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-6-quinolinyl)methanol, (R)-(3,3-difluorocyclobutyl)(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)-6-quinolinyl)methanol, cis-3-(difluoromethyl)-1-(6-(2-ethyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (trans)-1,1-difluoro-5-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)spiro[2.3]hexane-5-ol, (cis)-1,1-difluoro-5-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)spiro[2.3]hexane-5-ol, cis-3-(difluoromethyl)-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[3,2-d]pyrimidine-6-yl)cyclobutanol, cis-3-(difluoromethyl)-1-(5-methyl-2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, trans-3-hydroxy-1-methyl-3-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)cyclobutanecarbonitriel, cis-3-hydroxy-1-methyl-3-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclobutanecarbonitric, cis-3-(difluoromethyl)-1-(6-(2-methylimidazo[1,2-b]pyridazin-7-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, cis-3-(difluoromethyl)-1-(6-(2-methyl-3H-imidazo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, (R)-(3,3-difluorocyclobutyl)(3-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyrazine-6-yl)methanol, (S)-(3,3-difluorocyclobutyl)(3-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyrazine-6-yl)methanol, (2S)-2-(3,3-difluorocyclobutyl)-2-(3-methyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, (2R)-2-(3,3-difluorocyclobutyl)-2-(3-methyl-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)ethanol, cis-3-methoxy-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, cis-1-(2-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, cis-3-hydroxy-1-methyl-3-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanecarbonitric, trans-3-hydroxy-1-methyl-3-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanecarbonitric, cis-3-(difluoromethyl)-1-(6-(2-methylimidazo[1,2-a]pyrimidine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, trans-3-hydroxy-1-methyl-3-(2-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanecarbonitol, cis-3-hydroxy-1-methyl-3-(2-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanecarbonitric, cis-3-cyclopropyl-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, cis-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethoxy)cyclobutanol, cis-1-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)-3-(trifluoromethoxy)cyclobutanol, cis-3-methoxy-3-methyl-1-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, cis-3-(difluoromethyl)-1-(6-(3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, trans-3-hydroxy-1-methyl-3-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanecarbonitric, cis-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)[1,3]thiazolo[5,4-b]pyridin-2-yl)-3-(trifluoromethoxy)cyclobutanol, trans-3-hydroxy-1-methyl-3-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[3,2-b]pyridine-2-yl)cyclobutanecarbonitride, cis-3-hydroxy-1-methyl-3-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[3,2-b]pyridine-2-yl)cyclobutanecarbonitol, 5-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)spiro[2,3]hexane-5-ol, 5-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)spiro[2.3]hexane-5-ol, (R)-((1S)-2,2-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-((1R)-2,2-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (R)-((1R)-2,2-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, (S)-((1S)-2,2-difluorocyclobutyl)(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)methanol, cis-3-(difluoromethyl)-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)[1,3]thiazolo[5,4-d]pyrimidine-2-yl)cyclobutanol, cis-3-hydroxy-1-methyl-3-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanecarbonitric, cis-1-(2-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethoxy)cyclobutanol, cis-1-(5-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)-3-(trifluoromethoxy)cyclobutanol, trans-3-methoxy-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, cis-3-methoxy-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, trans-1,1-difluoro-5-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)spiro[2.3]hexane-5-ol, cis-1,1-difluoro-5-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)spiro[2.3]hexane-5-ol, trans-1,1-difluoro-5-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)spiro[2.3]hexane-5-ol, cis-1,1-difluoro-5-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)spiro[2.3]hexane-5-ol, 6,6-difluoro-2-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)spiro[3.3]heptan-2-ol, cis-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[3,2-b]pyridin-2-yl)-3-(trifluoromethoxy)cyclobutanol, trans-3-methoxy-3-methyl-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, cis-3-methoxy-3-methyl-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, cis-3-(methoxymethyl)-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, cis-1-(2-(1-methyl-1H-pyrazole-4-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, (S)-(3-amino-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(3,3-difluorocyclobutyl)methanol, (R)-(3-amino-6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)(3,3-difluorocyclobutyl)methanol, trans-3-methoxy-3-methyl-1-(2-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, cis-3-methoxy-3-methyl-1-(2-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutanol, cis-1-(2-(3-pyridinyl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, cis-1-(2-(6-quinoxalinyl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, cis-1-(2-(imidazo[1,2-a]pyrimidine-6-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, trans-3-methoxy-3-methyl-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)[1,3]thiazolo[5,4-b]pyridine-2-yl)cyclobutanol, cis-3-methoxy-3-methyl-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclobutanol, trans-3-methoxy-3-methyl-1-(6-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-yl)thieno[2,3-b]pyridine-2-yl)cyclobutanol, cis-1-(2-(4-pyridazinyl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, cis-3-methoxy-3-methyl-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[3,2-b]pyridine-2-yl)cyclobutanol, 3-(6-(cis-1-hydroxy-3-(trifluoromethyl)cyclobutyl)thieno[2,3-d]pyrimidine-2-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridine-7-one, cis-1-(2-([1,2,4]triazolo[4,3-a]pyrimidine-6-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, (R)-(3,3-difluorocyclobutyl)(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyrazine-6-yl)methanol, (S)-(3,3-difluorocyclobutyl)(2-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyrazine-6-yl)methanol, trans-3-methyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thieno[2,3-b]pyridine-2-yl)-3-(trifluoromethyl)cyclobutanol, cis-3-methyl-1-(6-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-b]pyridin-2-yl)-3-(trifluoromethyl)cyclobutanol, cis-1-(2-(2-methyl-2H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, cis-1-(2-(1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, cis-1-(2-(1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, cis-1-(2-(1,8-naphthyridine-3-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutanol, trans-3-(difluoromethyl)-1-(5-(2-methyl-2H-pyrazolo[3,4-b]pyridine-5-yl)thiazolo[5,4-b]pyridine-2-yl)cyclobutanol, trans-3-methoxy-1-(2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)thieno[2,3-d]pyrimidine-6-yl)cyclobutan-1-ol, or cis-1-(2-([1,2,4]triazolo[1,5-a]pyrimidine-6-yl)thieno[2,3-d]pyrimidine-6-yl)-3-(trifluoromethyl)cyclobutan-1-ol The compound or salt according to claim 1 or 4.

68. The aforementioned compound, 【Chemistry 21】 The compound or salt according to claim 1.

69. The aforementioned compound, 【Chemistry 22】 The compound or salt according to claim 1.

70. The aforementioned compound, 【Chemistry 23】 The compound or salt according to claim 1.

71. The aforementioned compound, 【Chemistry 24】 The compound or salt according to claim 1.

72. The aforementioned compound, 【Chemistry 25】 The compound or salt according to claim 1.

73. The aforementioned compound, 【Chemistry 26】 The compound or salt according to claim 1.

74. The aforementioned compound, 【Chemistry 27】 The compound or salt according to claim 1.

75. The aforementioned compound, 【Chemistry 28】 The compound or salt according to claim 1.

76. The aforementioned compound, 【Chemistry 29】 The compound or salt according to claim 1.

77. The aforementioned compound, 【Transformation 30】 The compound or salt according to claim 1.

78. The aforementioned compound, 【Chemistry 31】 The compound or salt according to claim 1.

79. The aforementioned compound, 【Chemistry 32】 The compound or salt according to claim 1.

80. The aforementioned compound, 【Transformation 33】 The compound or salt according to claim 1.

81. The aforementioned compound, 【Transformation 34】 The compound or salt according to claim 1.

82. The aforementioned compound, 【Chemistry 35】 The compound or salt according to claim 1.

83. The aforementioned compound, 【Transformation 36】 The compound or salt according to claim 1.

84. The aforementioned compound, 【Chemistry 37】 The compound or salt according to claim 1.

85. The aforementioned compound, 【Transformation 38】 The compound or salt according to claim 1.

86. The aforementioned compound, 【Chemistry 39】 The compound or salt according to claim 1.

87. The aforementioned compound, 【Chemistry 40】 The compound or salt according to claim 1.

88. The aforementioned compound, 【Chemistry 41】 The compound or salt according to claim 1.

89. The aforementioned compound, 【Chemistry 42】 The compound or salt according to claim 1.

90. The aforementioned compound, 【Chemistry 43】 The compound or salt according to claim 1.

91. The compound according to any one of claims 1 to 90.

92. A pharmaceutical composition comprising a compound according to any one of claims 1 to 90 or a compound according to claim 91, and a pharmaceutically acceptable excipient.

93. A compound or salt according to any one of claims 1 to 90, a compound according to claim 91, or a pharmaceutical composition according to claim 92, for use as a pharmaceutical agent.

94. A compound or salt according to any one of claims 1 to 90, the compound according to claim 91, or the pharmaceutical composition according to claim 92, for use in the treatment of 15-PGDH-mediated diseases or disorders.

95. A compound or salt according to any one of claims 1 to 90, a compound according to claim 91, or a pharmaceutical composition according to claim 92, for use in the treatment of inflammatory bowel disease.

96. A compound or salt according to any one of claims 1 to 90 or a compound according to claim 91, for use in the manufacture of a drug for the treatment of 15-PGDH-mediated diseases or disorders.

97. A method for treating intestinal disorders, gastrointestinal disorders, or bowel disorders in a subject in need thereof, comprising administering to the subject a therapeutically acceptable amount of a compound or salt according to any one of claims 1 to 90, a compound according to claim 91, or a pharmaceutical composition according to claim 92.

98. A method for producing the compound or salt described in claim 1 or 6, Formula (A-int-b) 【Chemistry 44】 The compound and formula (R2-B): 【Chemistry 45】 Perform Suzuki coupling between the compounds. (In the formula, X Ｈ is -Br or -Cl, B ａ This is a boronic acid group or a boronic acid ester group, 「 【Chemistry 46】 This indicates that a double bond or a single bond may be present. X ａ Each of these examples is, independently, nitrogen, oxygen, or carbon. Each example of r, if present, is an integer selected from 0, 1, 2, 3, 4, or 5, and two examples of r are the same R ２ If present on the base, the sum of both combined r values ​​does not exceed 5. R １２ Each example, if it exists and is coupled to an N-member, independently, C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkylene-OH or C １～６ Alkylene-OC １～６ It is alkyl, and R １２ Each example, when present and bonded to a C ring member, is independently -OH, oxo, -N(R) ｂ ) ２ , C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkoxy, C １～６ Alkylene-OH or C １～６ Alkylene-OC １～６ It is alkyl, R ｂ Each example, if present, independently of -H or C １～６ It is alkyl, or instead, it has two R's. ｂ The substituents together form a heterocyclyl having 3 to 6 ring members. R ｂ C １～６ It is alkyl, or instead, it has two R's. ｂ When the substituents together form a heterocycline having 3 to 6 ring members, R ｂ These are either unsubstituted or each is independently -F, -Cl, -OH, C １～３ (May be substituted with one or more substituents that are alkoxy) A method that includes this.

99. Formula (A-int-b) 【Chemistry 47】 The compound and formula (R2-B): 【Chemistry 48】 Perform Suzuki coupling between the compounds. (In the formula, X Ｈ is -Br or -Cl, B ａ This is a boronic acid group or a boronic acid ester group, 「 【Chemistry 49】 This indicates that a double bond or a single bond may be present. X ａ Each of these examples is, independently, nitrogen, oxygen, or carbon. Each example of r, if present, is an integer selected from 0, 1, 2, 3, 4, or 5, and two examples of r are the same R ２ If present on the base, the sum of both combined r values ​​does not exceed 5. R １２ Each example, if it exists and is coupled to an N-member, independently, C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkylene-OH or C １～６ Alkylene-OC １～６ It is alkyl, and R １２ Each example, when present and bonded to a C ring member, is independently -OH, oxo, -N(R) ｂ ) ２ , C １～６ Alkyl, C １～６ Haloalkyl, C １～６ Alkoxy, C １～６ Alkylene-OH or C １～６ Alkylene-OC １～６ It is alkyl, R ｂ Each example, if present, independently of -H or C １～６ It is alkyl, or instead, it has two R's. ｂ The substituents together form a heterocyclyl having 3 to 6 ring members. R ｂ C １～６ It is alkyl, or instead, it has two R's. ｂ When the substituents together form a heterocycline having 3 to 6 ring members, R ｂ These are either unsubstituted or each is independently -F, -Cl, -OH, C １～３ (May be substituted with one or more substituents that are alkoxy) The compound or salt according to claim 1, prepared by a method comprising the above.

100. A method for producing the compound or salt described in claim 1 or 27, wherein the intermediate is of formula (A-int-a): [Transformation 50] (In the formula, X Ｈ１ is -Cl, -Br, or -I, and X Ｈ２ (These are -Cl, -Br, -OTf, -OTs, or -OMs) A method comprising using a compound of the said compound or a pharmaceutically acceptable salt of the said compound.

101. A method for producing the compound or salt described in claim 1 or 6, wherein the intermediate is of formula (A-int-b): 【Chemistry 51】 (In the formula, X Ｈ２ (These are -Cl, -Br, -OTf, -OTs, or -OMs) A method comprising using the compound.

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