Methods and compositions for regulating plasminogen activation inhibitor 1 (PAI-1)

Abstract

An siRNA molecule for suppressing the expression of plasminogen activator inhibitor 1 (PAI-1) is disclosed. The siRNA molecule may comprise a sense strand and an antisense strand. In some embodiments, the sense strand has at least 80% sequence identity to one of SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, or SEQ ID NO:9. In some embodiments, the antisense strand has at least 80% sequence identity to one of SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, or SEQ ID NO:10. The sense strand and / or antisense strand may comprise one or more modified nucleotides. The sense strand and / or antisense strand may comprise a ligand. Lipid nanoparticles comprising the siRNA molecule are also disclosed. Methods for treating subjects suffering from at least one PAI-1 related condition, disease, or disorder using the siRNA molecule or lipid nanoparticles comprising the siRNA molecule are also disclosed.

Images