Recombinant AAV with improved directivity and specificity
JP2026518993APending Publication Date: 2026-06-11AFFINIA THERAPEUTICS INC
View PDF 0 Cites 0 Cited by
Patent Information
- Application Number
- JP2025567629
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-05-07
- Filing Date
- 2024-05-16
- Publication Date
- 2026-06-11
Smart Images
Figure 2026518993000485 
Figure 2026518993000486 
Figure 2026518993000487
Abstract
This disclosure provides a modified AAV capsid protein comprising a targeted peptide in variable region VIII (VR VIII) and / or a peptide segment in variable region I (VR I). The modified AAV capsid protein can form rAAVs with preferred directivity, specificity, or biodistribution in vivo or in vitro. The rAAVs of this disclosure can be used in gene therapies targeting specific tissues.
Need to check novelty before this filing date? Find Prior Art