Improved therapeutic regimens for therapeutic effector components that act via intracellular molecular targets

Saponin components enhance the duration and frequency of oligonucleotide therapeutics by promoting endosomal escape, addressing inefficiencies in delivery and dosing frequency, and reducing treatment costs.

JP2026519131APending Publication Date: 2026-06-11SAPREME TECH BV
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
SAPREME TECH BV
Filing Date
2024-05-28
Publication Date
2026-06-11

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Abstract

The present invention relates to the field of therapy. More specifically, the present invention relates to a therapeutic method for administering an effector component that requires cellular uptake to become effective and / or exerts its effects via intracellular (molecular) targets, such as nucleic acid or oligonucleotide therapeutics, for example, but not limited to these. The present invention provides modalities for extending the duration of effect of an effector component, and / or extending the dosing interval of the effector component, and / or reducing the dosing frequency of the effector component, and / or causing a (delayed) boost of the effect of the effector component.
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