Spray-drying composition containing an adrenaline receptor modulator
A stable amorphous powder composition of epinephrine with maltodextrin carrier addresses the instability and convenience issues of current auto-injectors, enhancing shelf life and bioavailability for transmucosal delivery.
JP2026519542APending Publication Date: 2026-06-16OREXO AB
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- OREXO AB
- Filing Date
- 2024-05-31
- Publication Date
- 2026-06-16
AI Technical Summary
Technical Problem
Current epinephrine auto-injectors are inconvenient for self-administration, chemically unstable, and have limited shelf life, leading to waste and reduced bioavailability due to instability and formulation challenges in transmucosal delivery systems.
Method used
A stable, amorphous single-particle powder composition of epinephrine or its salt, formulated with maltodextrin as a carrier, providing rapid absorption and improved bioavailability through spray-drying, suitable for transmucosal delivery.
Benefits of technology
The composition exhibits enhanced physical and chemical stability, allowing for extended shelf life and rapid pharmacological effects with minimal adverse events, improving patient compliance and reducing waste.
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Smart Images
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Abstract
The present invention provides a pharmaceutically acceptable composition in the form of a solid amorphous single-particle powder, comprising a mixture of (a) a pharmacologically effective dose of an adrenergic receptor modulator or a pharmaceutically acceptable salt thereof, and (b) a pharmaceutically acceptable carrier material comprising maltodextrin, wherein the solid composition exhibits a pH of about 4.5 to about 8.0 when dissolved in an aqueous medium. The composition is suitable for transmucosal drug delivery, for example, nasal delivery, and can be loaded into a single-use nasal applicator. The composition may further comprise a disaccharide, such as lactose or trehalose, which may be prepared by spray drying and spray-dried together with the active ingredient and maltodextrin. The composition may further comprise one or more alkylsaccharides. Preferred alkylsaccharides include sucrose esters such as sucrose monolaurate. A preferred adrenergic receptor modulator is epinephrine (adrenaline). Therefore, the composition is particularly useful in the treatment of allergic reactions, including anaphylaxis.
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