Blood urea nitrogen (BUN) sensor and method for detecting blood urea nitrogen in biological samples
The BUN sensor system addresses inaccuracies by using differential carbon dioxide detection in a two-component setup, ensuring accurate urea nitrogen measurement without enzyme redundancy and ammonia interference.
JP2026524941APending Publication Date: 2026-07-24SIEMENS HEALTHCARE DIAGNOSTICS INC
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Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- SIEMENS HEALTHCARE DIAGNOSTICS INC
- Filing Date
- 2024-07-15
- Publication Date
- 2026-07-24
AI Technical Summary
Technical Problem
Conventional BUN sensors are adversely affected by potassium ions, pH levels, and background ammonia, leading to measurement inaccuracies, and lack a correction mechanism for background ammonia.
Method used
A sensor system utilizing two sensor components, one with a urease enzyme and one without, generates differential voltage signals to measure urea nitrogen by detecting carbon dioxide byproducts, and a computer processor converts these signals to urea nitrogen levels using the Nernst equation.
Benefits of technology
The system provides accurate urea nitrogen measurements unaffected by potassium ions and background ammonia, reducing complexity and cost by eliminating the need for multiple enzymes and correction algorithms.
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Abstract
One embodiment of a blood urea nitrogen (BUN) sensor measures urea nitrogen in a biological sample by measuring a differential voltage signal based on first and second voltage signals, each representing the amount of carbon dioxide detected. The first signal represents the amount of detected carbon dioxide resulting from an enzymatic reaction in the biological sample where a urease enzyme comes into contact with the immobilized sensor surface. The second voltage signal represents the amount of background carbon dioxide detected in the biological sample. The differential voltage signal indicates the amount of urea nitrogen in the biological sample, which can be determined by appropriate correlation. Other embodiments of the BUN sensor and methods for detecting BUN are also provided, as in other embodiments.
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