Rapid detection device for liquid samples

Abstract

A rapid detection device is provided that significantly improves detection efficiency while ensuring high accuracy. [Solution] The rapid detection device includes an insertion plate (1), a detection element (3), a deployment assisting element (4), and a cover layer (5). The detection surface of the insertion plate is provided with a detection area and a sample chamber, and the detection area is provided with one card slot or multiple parallel card slots. The ends of each card slot are connected to the sample chamber. The detection element is installed in the card slot. The sample chamber is provided with a liquid-absorbing deployment assisting element. The insertion plate is equipped with a deployment assisting element that covers the bottoms of all detection elements on the same detection surface. The deployment assisting element, made of glass fiber sheet, polyester film, or absorbent paper, allows the sample liquid to reach all detection elements quickly and uniformly, and each detection element deploys quickly and synchronously. This effectively shortens the detection time, making it possible to obtain detection results in one minute.

Description

[Technical Field]

[0001] The present invention relates to the technical field of sample detection, and more particularly to a device for rapid detection of liquid samples. [Background technology]

[0002] Drug abuse is a global problem, severely impacting public health, social stability, and economic development. According to the 2023 World Drug Report published by the United Nations Office on Drugs and Crime, there are approximately 13.2 million injection drug users worldwide, an 18% increase from previous estimates. Furthermore, the number of global drug users in 2021 exceeded 296 million, a 23% increase from 10 years ago. The illegal drug economy causes environmental destruction, and in the Amazon basin, it fuels other criminal activities and causes environmental damage. Furthermore, synthetic drugs, particularly methamphetamine (commonly known as "ice") and fentanyl, are increasingly dominating the global drug market. The current drug abuse situation is serious worldwide, and illegal drug economic activity is widespread, presenting significant challenges for countries and international organizations. Rapid and easy-to-use on-site detection devices are needed to monitor drug abuse and crack down on illegal drug economic and trade activities.

[0003] Existing detection devices are based on the principles of immunoassay, chromatography, mass spectrometry, etc., and these devices and technologies can be used to detect drugs on-site. However, the detection efficiency is extremely low, and even the most widely used detection devices currently require more than three minutes to obtain detection results. Summary of the Invention

[0004] To solve the problems of the prior art, the present invention provides a rapid detection device for detecting liquid samples.

[0005] The present invention provides a rapid liquid sample detection device that includes an insert plate, a detection element, a deployment assisting element, and a cover layer. The insert plate is provided with one or more detection surfaces, and the detection surface of the insert plate is provided with a detection area and a sample chamber. The detection area is provided with one card slot or multiple card slots arranged in parallel, and each card slot has an end connected to a sample chamber. The detection element is attached to the card slot, and the sample application area at the bottom end of the detection element is located within the sample chamber. The sample chamber is provided with a liquid-absorbing deployment assisting element, which covers the sample application areas at the bottom ends of all detection elements on the same detection surface. The cover layer is in close contact with the detection surface of the insert plate, and the cover layer is provided with a sample application window aligned with the deployment assisting element.

[0006] Preferably, the deployment assisting member is made of a glass fiber sheet, a polyester film, or absorbent paper.

[0007] Preferably, only one side of the insert plate is a detection surface.

[0008] Preferably, both side surfaces of the insertion plate are detection surfaces.

[0009] Preferably, the card slots on both detection surfaces of the insert plate are aligned with each other, and the bottom of the insert plate is provided with n sample flow holes, where n is the number of card slots on a single detection surface, and the n sample flow holes are aligned with the ends of the n card slots on the same detection surface. The sample chambers on both detection surfaces of the insert plate are in communication with each other via the sample flow holes.

[0010] Preferably, there is a region where the sample flow hole and the deployment assisting member partially overlap.

[0011] Preferably, both side walls of each card slot are provided with pins for fixing the detection members.

[0012] Preferably, any two adjacent card slots on the same detection surface are separated by a convex rib, and the convex rib has an opening that connects the two adjacent card slots. More preferably, the position of the opening is aligned with the marking pad area of ​​the detection member.

[0013] Preferably, the outer walls of the two card slots closest to both side edges of the insertion plate are both provided with groove structures, and these two groove structures are aligned with the openings on the protruding ribs.

[0014] Preferably, some or all of the protruding ribs have a channel structure in them, the length of which is parallel to the length of the card slot, and the bottom end of which communicates with the sample chamber.

[0015] Preferably, all or part of the detection surface of the insert plate is provided with a residual sample reservoir above the detection area, and the apex of the channel structure communicates with the residual sample reservoir.

[0016] Preferably, a protective cover is also included, and the protective cover has an insertion groove structure corresponding to the bottom of the insertion plate, and in an initial state, the bottom of the insertion plate is inserted into the insertion groove structure of the protective cover.

[0017] Preferably, the inner wall of the protective cover is provided with one or more reinforcing structures.

[0018] The beneficial effects of this invention are as follows: 1. This device uses a deployment support element on the insertion plate that covers the bottom of all the detection elements on the same detection surface. The deployment support element, made of glass fiber sheet, polyester film, or absorbent paper, allows the liquid sample to reach all the detection elements quickly and evenly, allowing each detection element to deploy quickly and synchronously. This shortens the detection time, allowing detection results to be obtained in just one minute, significantly improving detection efficiency while maintaining high accuracy. 2. This device has vertical and horizontal exhaust structures installed on the detection surface of the insertion plate, which effectively exhausts air inside each card slot, preventing the pressure inside the card slot from being released and adversely affecting the deployment effect. 3. The present invention provides a detection element and a deployment assist element on both sides of the insertion plate, which can increase the types of objects that can be detected by the detection device. [Brief explanation of the drawings]

[0019] [Figure 1] FIG. 1 is an exploded view of a first embodiment of the present invention. [Figure 2] FIG. 2 is a front view of the insertion plate according to the first embodiment of the present invention. [Figure 3] FIG. 3 is a schematic diagram of the insertion plate with the detection member attached thereto in the first embodiment of the present invention. [Figure 4] FIG. 4 is a schematic diagram of the inside of the protective cover according to the first embodiment of the present invention. [Figure 5] FIG. 5 is an exploded view of the second embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0020] The structure of the present invention will be described in detail below with reference to examples, which are preferred embodiments of the present invention and are not intended to limit the present invention.

[0021] Example 1 As shown in Figure 1, the device for rapid detection of liquid samples includes an insert plate 1, a cover layer 5, a protective cover 2, and a detection member 3. The insert plate 1 is a rigid structure, and both sides are detection surfaces. The protective cover 2 has an insert groove structure corresponding to the bottom of the insert plate 1, and the bottom of the insert plate 1 is inserted into the insert groove structure of the protective cover 2.

[0022] The detection surface of the insertion plate 1 is divided into a top region, a detection region, and a sample addition region, from top to bottom. The detection region has six card slots 1-1 spaced apart along the width of the insertion plate 1. Each card slot 1-1 has a pin 1-2 on each side wall for fixing the detection element 3. Adjacent card slots 1-1 are separated by a convex rib 1-3. The card slots 1-1 are used to accommodate the detection element 3. In this embodiment, the detection element 3 uses a test strip. The outer surface of the convex rib 1-3 is flush with the edge of the detection surface. The sample addition region of the detection surface has a recessed sample chamber 1-4. The ends (bottom ends) of each card slot 1-1 are connected to the top of the sample chamber 1-4. The sample addition region at the bottom end of the detection element 3 extends into the sample chamber 1-4.

[0023] A deployment assisting member 4 is provided in each sample chamber 1-4. The deployment assisting member 4 covers the sample application areas at the bottom ends of all detection members 3 on the same detection surface. The deployment assisting member 4 allows the liquid sample to be quickly absorbed, promoting deployment, ensuring high accuracy and significantly improving detection efficiency. In this embodiment, the deployment assisting member 4 is a glass fiber sheet. In other embodiments, the deployment assisting member 4 is a polyester film or absorbent paper.

[0024] A cover layer 5 corresponds to each detection surface of the insertion plate 1. The two cover layers 5 are respectively attached to both detection surfaces of the insertion plate 1, and the cover layers 5 prevent the detection members 3 from moving or falling off during transportation and detection, promote deployment, and ensure the effectiveness of detection. In this embodiment, the cover layers 5 are adhesive sheets for panels.

[0025] The insert plate 1 can be made of either a transparent or opaque material, and the cover layer 5 can be made of either a transparent or opaque material. The insert plate 1, whether transparent or not, and the cover layer 5 can be combined in any way. The cover layer 5 can be made of either a flexible or rigid material.

[0026] The cover layer 5 is provided with six sets of observation windows corresponding to the six card slots 1-1. Each set of observation windows includes two observation windows corresponding to the object name display area and object detection result display area on the detection member 3. The cover layer 5 is also provided with a sample addition window 5-1 corresponding to the deployment assist member 4.

[0027] Six sample flow holes 1-5 located in the sample addition area are provided at the bottom of the insertion plate 1. The six sample flow holes 1-5 correspond to the bottom ends of the six card slots 1-1 on the same detection surface, respectively, and the six sample flow holes 1-5 connect the sample chambers 1-4 at the bottom of both detection surfaces of the insertion plate 1, improving the uniformity of development.

[0028] In an optional preferred embodiment, there is a partial overlapping region between the sample flow holes 1-5 and the deployment assisting member 4.

[0029] In some embodiments, residual sample reservoirs 1-6 are provided in the top region of the detection surface of the insert plate 1. Depending on the actual application, residual sample reservoirs 1-6 can be provided on only one detection surface or on both detection surfaces.

[0030] In some embodiments, openings 1-8 are provided in all of the protruding ribs 1-3. Both ends of the openings 1-8 are connected to the two adjacent card slots 1-1. The positions of the openings 1-8 correspond to the marking pad areas of the detection member 3. The two card slots 1-1 closest to the side edges of the insertion plate 1 each have a groove structure on the outer wall. These two groove structures correspond to the openings 1-8 in the protruding ribs 1-3 and form a lateral exhaust structure when attaching the cover layer 5. Furthermore, the openings 1-8 also serve to prevent the liquid sample from flowing upward by capillary action through the gap formed along the side wall of the card slot 1-1 and the side edge of the detection member 3.

[0031] In some embodiments, a channel structure 1-7 is provided in the elongated convex rib 1-3. Both ends of the channel structure 1-7 are connected to the residual sample reservoir 1-6 in the top region and the sample chamber 1-4 in the sample addition region, respectively. The channel structure 1-7 functions as a vertical exhaust structure when the cover layer 5 is attached, and also sucks excess liquid sample from the sample chamber 1-4 into the residual sample reservoir 1-6 by capillary action. The channel structure 1-7 is blocked by an opening 1-8 in the convex rib 1-3.

[0032] In some embodiments, partition structures 1-9 are provided in some of the channel structures 1-7. More preferably, channel structures 1-7 provided with partition structures 1-9 and channel structures 1-7 without partition structures 1-9 are alternately arranged along the arrangement direction of each channel structure 1-7. The partition structures 1-9 are useful for increasing the pressure difference and improving the exhaust effect.

[0033] In some embodiments, the edges of the detection surface of the insert plate 1 are provided with a circumferential flange structure 1-10. The cover layer 5 is provided inside the flange structure 1-10. On the one hand, this flange structure 1-10 prevents the center of the detection surface from coming into direct contact with the support surface when the insert plate 1 is placed flat, and serves to protect the cover layer 5 and the detection element 3. On the other hand, it provides accurate positioning when attaching the cover layer 5.

[0034] In some embodiments, the residual sample reservoirs 1-6 in the top region of the detection surface of the insert plate 1 are single-hole or multi-hole structures.

[0035] In some embodiments, the pore structure of the residual sample reservoirs 1-6 is an ordered honeycomb structure.

[0036] In some embodiments, the residual sample reservoirs 1-6 are located at the top end of the insert plate 1 and are formed as a single square or an array of squares.

[0037] In some embodiments, the residual sample reservoir 1-6 is located at the top end of the insert plate 1, and the residual sample reservoir 1-6 can communicate with one channel structure 1-7 or multiple channel structures 1-7.

[0038] In some embodiments, the rigid insert plate 1 is unitarily molded, and more particularly, is unitarily injection molded.

[0039] In some embodiments, the detection surface may have one or more card slots 1-1, and the number of pins 1-2 on the card slot 1-1 may be multiple. Each pin 1-2 may be located at the top, center, or bottom of the side wall of the card slot 1-1, or at any other position on the card slot 1-1, and may be symmetrical or asymmetrical. The pins 1-2 help prevent the liquid sample from flowing upward by capillary action through the gap formed along the side wall of the card slot 1-1 and the side edge of the detection member 3. The size of the pins 1-2 must be larger than the size at which capillary flow is formed, so as to effectively prevent the liquid from passing through the gap between the side edge of the detection member 3 and the side wall of the card slot 1-1.

[0040] In some embodiments, the card slot 1-1 can accommodate one or more detection members 3.

[0041] In some embodiments, the bottom surfaces of the sample chambers 1-4 are flat or beveled. Preferably, the bottom surfaces of the sample chambers 1-4 are flat.

[0042] In some embodiments, the openings 1-8 in the convex ribs 1-3 are formed by hollowing out the bottom of the convex ribs 1-3. The openings 1-8 in the channel structures 1-7 are provided at any positions on the channel structures 1-7.

[0043] In some embodiments, a reinforcing structure 2-1 is provided in the inner cavity of the protective cover 2. On the one hand, the reinforcing structure 2-1 improves the structural strength of the protective cover 2 and ensures that the protective cover 2 maintains a certain supporting function. On the other hand, the four reinforcing structures 2-1 cooperate to sandwich the bottom of the insert plate 1, firmly fixing the insert plate 1 after the detection element 3 and the cover layer 5 are assembled, and preventing the protective cover 2 from falling off.

[0044] In some embodiments, the reinforcing structures 2-1 in the protective cover 2 are in one or more rows.

[0045] In some embodiments, the four corners of the bottom of the cavity in the protective cover 2 are provided with reinforcing structures 2-1.

[0046] In some embodiments, the reinforcing structures 2-1 within the protective cover 2 are located on both the left and right sides of the inside of the protective cover 2.

[0047] In some embodiments, the reinforcing structures 2-1 within the protective cover 2 are located on both the front and rear sides of the inside of the protective cover 2.

[0048] In some embodiments, the reinforcing structure 2-1 within the protective cover 2 is located on the left side of the inside of the protective cover 2.

[0049] In some embodiments, the reinforcing structure 2-1 within the protective cover 2 is located on the right side of the inside of the protective cover 2.

[0050] In some embodiments, the reinforcing structure 2-1 in the protective cover 2 is located on the front side of the inside of the protective cover 2.

[0051] In some embodiments, the reinforcing structure 2-1 in the protective cover 2 is located on the rear side of the inside of the protective cover 2.

[0052] The operating principle of this embodiment is as follows. The protective cover 2 and the insertion plate 1 are separated, and the bottom of the insertion plate 1 is inserted into the test sample so that the deployment assisting member 4 comes into contact with the test sample. After a certain period of time, the plate is removed. The test sample in the sample chambers 1-4 is guided by the deployment assisting member 4 to quickly and thoroughly contact each detection member 3, and each detection member 3 begins to deploy quickly. After deployment is complete, the detection results can be observed through the observation window in the cover layer 5. During the deployment process, the detection device can be deployed normally in an upright position, flat position, or any other orientation.

[0053] In another embodiment, the test liquid sample is placed in the protective cover 2, and the bottom of the insertion plate 1 is inserted into the protective cover 2 so that the deployment assisting member 4 comes into contact with the test sample. After a certain period of time, it is removed. The detection member 3 deploys, and the detection result corresponding to the analyte on the detection member 3 is read one minute later.

[0054] The process of inserting the bottom of the insertion plate 1 into the liquid sample to be tested can be performed in a stationary or moving state, and the holding method is preferably in a stationary state. The holding time is 1 second to 1 hour, preferably 1 to 15 seconds.

[0055] Example 2 This is a rapid detection device for liquid samples, and the difference between this embodiment and the first embodiment is that only one side of the insertion plate 1 is a detection surface, and the other detection surface does not have a card slot 1-1. [Explanation of symbols]

[0056] 1. Insertion plate 1-1, card slot 1-2, pin 1-3, convex rib 1-4, Sample room 1-5, sample flow hole 1-6, residual sample storage chamber 1-7. Channel structure 1-8, opening 1-9. Partition structure 1-10. Convex edge structure 2. Protective cover 2-1. Reinforcement structure 3. Detection element 4. Deployment support parts 5. Cover layer 5-1. Sample addition window

Claims

1. A device for rapid detection of liquid samples, comprising an insertion plate (1), a detection member (3), a deployment assisting member (4), and a cover layer (5); The insertion plate (1) is provided with one or more detection surfaces, The detection surface of the insert plate (1) is provided with a detection area and a sample chamber (1-4), The detection area is provided with one card slot (1-1) or multiple parallel card slots (1-1), The ends of each card slot (1-1) are connected to the sample chamber (1-4), The detecting member (3) is mounted in the card slot (1-1), The sample application area of ​​the detection member (3) is located within the sample chamber (1-4), The sample chamber (1-4) is provided with the development assisting member (4) for absorbing liquid, The deployment assisting member (4) covers the sample application areas of all the detection members (3) on the same detection surface, The cover layer (5) is in close contact with the detection surface of the insert plate (1), The rapid detection device for liquid samples is characterized in that the cover layer (5) is provided with a sample addition window (5-1) aligned with the deployment assisting member (4).

2. 2. The device for rapid detection of liquid samples according to claim 1, wherein the deployment assisting member (4) is a glass fiber sheet, a polyester film, or absorbent paper.

3. 2. The device for rapid detection of liquid samples according to claim 1, wherein the insert plate (1) has a detection surface on only one side.

4. 2. The device for rapid detection of liquid samples according to claim 1, wherein both sides of the insertion plate (1) are detection surfaces.

5. The card slots on both detection surfaces of the insertion plate (1) are aligned with each other; The bottom of the insert plate (1) is provided with n sample flow holes (1-5), n is the number of card slots in a single detection surface; The n sample flow holes (1-5) are aligned with the ends of the n card slots (1-1) on the same detection surface, respectively; 5. The device for rapid detection of liquid samples according to claim 4, wherein the sample chambers (1-4) on both detection faces of the insert plate (1) communicate with each other via sample flow holes (1-5).

6. Any two adjacent card slots (1-1) on the same detection surface are separated by a convex rib (1-3), 2. The rapid detection device for liquid samples according to claim 1, wherein the convex rib (1-3) has an opening (1-8) that connects two adjacent card slots (1-1).

7. Some or all of the convex ribs (1-3) have channel structures (1-7) therein; The rapid detection device for liquid samples according to claim 6, characterized in that the length of the channel structure (1-7) is parallel to the length of the card slot, and the bottom end communicates with the sample chamber.

8. The entire or part of the detection surface of the insert plate (1) is provided with a residual sample reservoir (1-6) located above the detection area; 2. The device for rapid detection of liquid samples according to claim 1, characterized in that the apex of the channel structure (1-7) communicates with the residual sample reservoir (1-6).

9. It further includes a protective cover (2), The protective cover (2) is provided with an insertion groove structure corresponding to the bottom of the insertion plate (1); 2. The device for rapid detection of liquid samples as claimed in claim 1, wherein in an initial state, the bottom of the insertion plate (1) is inserted into the insertion groove structure of the protective cover (2).

10. The device for rapid detection of liquid samples according to claim 9, characterized in that the inner wall of the protective cover (2) is provided with one or more reinforcing structures (2-1).

Images