CSF1R INHIBITORS FOR USE IN THE TREATMENT OF CANCER - Patent application

Abstract

Described herein are methods for treating cancers and other tumors associated with reduced proliferation, depletion, or repolarization of tumor-associated macrophages (TAMs), and CSF1R inhibitors for use in treating related disorders, including tendon sheath giant cell tumors (TGCTs) and diffuse tendon sheath giant cell tumors (DTGCTs).

Description

Related Applications

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS (0001) This application claims priority to U.S. Application No. 62 / 786,105, filed December 28, 2018, U.S. Application No. 62 / 926,341, filed October 25, 2019, and U.S. Application No. 62 / 933,830, filed November 11, 2019, the contents of each of which are incorporated herein by reference in their entirety. [Background technology]

[0002] (0002) Colony-stimulating factor 1 receptor (CSF1R) and its ligand, colony-stimulating factor 1 (CSF1), together form the lineage dependency for normal macrophage development and differentiation from monocytes. Therefore, tumor-associated macrophages (TAMs) depend on CSF1R (also known as FMS) kinase activity for proliferation and maintenance of their differentiated state and immunosuppressive phenotype. The role of TAMs in promoting an invasive and immunosuppressive tumor microenvironment is well established. TAMs mediate tumor growth, angiogenesis, invasiveness, metastasis, and immunosuppression through the secretion and response of various cytokines or other soluble factors. TAMs educate tumors by attenuating cytotoxic T cell immune responses, thereby shielding them from T cell eradication and allowing tumors to escape immune surveillance. For example, TAMs express PD-L1, a known immunosuppressive checkpoint that induces T cell anergy.

[0003] (0003) Several inhibitors targeting CSF1R have advanced to the clinic as direct antitumor therapies and potential immunotherapies. Many of these drugs also inhibit the closely related type III tyrosine receptor kinases KIT, PDGFRα / β, and FLT3, which may limit their usefulness due to off-target toxicity. Antibodies targeting CSF1R are much more specific but, among other drawbacks, blockade of CSF1 clearance results in a >10,000-fold increase in plasma levels of CSF1, the ligand for CSF1R.

[0004] Giant cell tumor of tendon sheath (TGCT) is a proliferative and inflammatory disease that includes the entity formerly known as pigmented villonodular synovitis (PVNS) and giant cell tumor of tendon sheath (GCTTS), both intra-articular and extra-articular. It is a rare neoplasm of the joint or tendon sheath, characterized by destructive proliferation of synovial membranes containing mononuclear cells intermixed with multinucleated giant cells, foam cells, siderophagocytic cells, and inflammatory cells. There are two types of TGCT: localized or nodular (involving the tendons supporting the joint or in one area of ​​the joint) and diffuse (involving the entire lining of the joint). Treatment involves surgical removal of the tumor. However, marginal resection of the diffuse form of TGCT is often difficult, resulting in a high recurrence rate. This may be characterized by overexpression of CSF1.

[0005] (0005) There is a need for selective small molecule CSF1R inhibitors useful in treating disorders associated with the proliferation of TAMs, including solid tumors of various cancers, and mesenchymal tumors, including TGCT and diffuse giant cell tumor of tendon sheath (DTGCT). Summary of the Invention

[0006]

[0006] Provided herein, in part, is a method for treating disorders such as giant cell tumor of tendon sheath and / or cancer in a patient in need thereof, comprising orally administering to the patient a therapeutically effective amount of the compound 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one, or a pharmaceutically acceptable salt thereof.

[0007]

[0007] For example, described herein is a method of treating cancer selected from the group consisting of solid tumors, acute myeloid leukemia, myelodysplastic syndrome, acute lymphocytic leukemia, and chronic lymphocytic leukemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the compound 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one or a pharmaceutically acceptable salt thereof, wherein administering comprises administering a loading dose of the compound daily for a first period; and administering a maintenance dose of the compound once weekly, twice weekly (also described as biweekly), or three times weekly for a second period.

[0008]

[0008] The present disclosure also provides a method of treating a tumor, e.g., GCTTS, PVNS, TGCT, or DTGCT, comprising administering to a patient a therapeutically effective amount of the compound 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one or a pharmaceutically acceptable salt thereof, wherein administering comprises administering a loading dose of the compound daily for a first period; and administering a maintenance dose of the compound once weekly, twice weekly, or three times weekly for a second period.

[0009]

[0009] Also contemplated herein is a method of inhibiting proliferation of cells known to have expression of the receptor colony-stimulating factor 1 receptor (CSF1R) or its ligands colony-stimulating factor 1 (CSF1) or interleukin (IL)-34 in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the compound 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one or a pharmaceutically acceptable salt thereof, wherein administering comprises administering a loading dose of the compound daily for a first period; and administering a maintenance dose of the compound once weekly, twice weekly, or three times weekly for a second period. [Brief explanation of the drawings]

[0010] [Figure 1]

[0010] Figure 1 shows the dose-dependent changes in the amount of CD11b+ / F4 / 80+ intratumoral macrophages in mice treated with Compound 1. [Figure 2]

[0011] Figure 2 shows the change in the amount of CD11b+ / F4 / 80+ intratumoral macrophages in mice treated with Compound 1 compared to treatment with vehicle or isotype control. [Figure 3]

[0012] Figure 3 shows a graphical representation demonstrating the depletion of CSF1R-expressing monocytes in peripheral blood from patients treated with Compound 1.

[0011] (0013) [Figure 4] FIG. 4 shows a graphical representation demonstrating the increase in CSF1 in plasma from patients treated with Compound 1. [Figure 5]

[0014] Figure 5 shows the plasma concentration of Compound 1 as a function of time on Day 1 of Cycle 2 for each subject in Cohorts 1-7, as described in Example 3. [Figure 6-1](0015) Figure 6 shows (A) CSF1 plasma concentrations in each subject of cohorts 1-7 described in Example 3 over different periods in a particular cycle (day 1 of cycle 1; day 15 of cycle 1; and day 1 of cycle 2); (B) IL-34 plasma concentrations in each subject of cohorts 1-7 described in Example 3 over different periods in a particular cycle (day 1 of cycle 1; day 15 of cycle 1; and day 1 of cycle 2); and (C) the percentage change in CD16+ monocyte population in each subject of cohorts 1-7 described in Example 3 over different periods in a particular cycle (day 1 of cycle 1; day 15 of cycle 1; and day 1 of cycle 2). [Figure 6-2] Same as above. [Figure 7]

[0016] Figure 7 shows (A) the percent change in CD163+ macrophages in patients in selected cohorts defined by the maintenance dose in Example 3 and (B) representative tumor biopsies at baseline and day 15 of cycle 2 in patients with pancreatic or colorectal cancer. [Figure 8]

[0017] Figures 8A, 8B, and 8C show the percentage reduction in diffuse giant cell tumor size in patient 1 (A), patient 2 (B), and patient 3 (C) of an additional DTGCT case study described in Example 4 herein at specific time points in specific cycles, as determined according to RECIST version 1.1. [Figure 9]

[0018] Figures 9 and 10 show MRI images of tumor sites in typical DTGCT patients 1 and 2, respectively, described in Example 4 herein. [Figure 10] Same as above. [Figure 11]

[0019] Figure 11 shows (A) CSF1 plasma concentrations in each subject of Cohorts 1-7, as described in Example 3, over different periods in a particular cycle (Day 1 of Cycle 1; Day 15 of Cycle 1; and Day 1 of Cycle 2), with corresponding data for Patients 1, 2, and 3 of the DTGCT case study described in Example 4; (B) CSF1 plasma concentrations in each subject of Cohorts 1-7, as described in Example 3, over different periods in a particular cycle (Day 1 of Cycle 1; Day 15 of Cycle 2; and Day 1 of Cycle 2), with corresponding data for Patients 1, 2, and 3 of the DTGCT case study described in Example 4. (C) IL-34 plasma concentrations in each subject from Cohorts 1-7, as described in Example 3, over different periods in a particular cycle (Day 1 of Cycle 1; Day 15 of Cycle 1; and Day 1 of Cycle 2), with corresponding data for patients 2 and 3 of the DTGCT case study, as described in Example 4. [Figure 12]

[0020] Figure 12 shows typical IC50 values ​​of Compound 1 or pexidartinib for inhibition of M-NFS-60 cell proliferation in the presence of various levels of the CSF1R ligand, CSF1. [Figure 13]

[0021] Figure 13 shows typical total steady-state exposure of Compound 1 and its active metabolites in a typical 13-week GLP-compliant toxicity study in patients, as well as in rats and dogs, on day 1 of cycle 2 of the study described in Example 8. [Figure 14]

[0022] Figure 14 shows a representative study of steady-state exposure of pexidartinib in rats and humans. [Figure 15]

[0023] Figure 15 shows an exemplary graphical representation illustrating the depletion of CD16+ monocytes in peripheral blood from patients treated with Compound 1.

[0012] (0024) [Figure 16]FIG. 16 shows an exemplary graphical representation demonstrating the increase in CSF1 and IL-34 in plasma from patients treated with Compound 1. [Figure 17]

[0025] Figure 17 shows a typical simulation of dosing of Compound 1. Simulated concentrations are plotted for Compound 1 when administered at three different dosing regimens: (1) 10 mg QD, (2) a 5-day 30 mg QD loading dose followed by a 30 mg twice-weekly maintenance dose, and (3) a 30 mg QD loading dose followed by a 10 mg QD maintenance dose for 3 days. The pharmacokinetic simulations are based on a preliminary nonparametric stratification using Cohorts 1-7 data from patients with evaluable pharmacokinetics at the time of analysis. DETAILED DESCRIPTION OF THE INVENTION

[0013] definition

[0026] As used herein, "DTGCT" refers to diffuse giant cell tumor of the tendon sheath.

[0014] (0027) "Individual," "patient," or "subject" are used interchangeably herein and include any animal, including mammals, including mice, rats, other rodents, rabbits, dogs, cats, pigs, cows, sheep, horses, or primates, and humans. The compounds described herein can be administered to mammals such as humans, but can also be administered to other mammals, such as animals requiring veterinary treatment, for example, companion animals (e.g., dogs, cats, etc.), livestock (e.g., cows, sheep, pigs, horses, etc.), and laboratory animals (e.g., rats, mice, guinea pigs, etc.). The mammal treated in the methods described herein is preferably a mammal, such as a human, for whom treatment of the disorders described herein is desired.

[0015]

[0028] As used herein, the term "pharmaceutically acceptable salt(s)" refers to salts of acidic or basic groups that may be present in compounds used in the compositions. Compounds included in the present compositions that are basic in nature can form a wide variety of salts with various inorganic and organic acids. Acids that can be used to prepare pharmaceutically acceptable acid addition salts of such basic compounds are those that form non-toxic acid addition salts, i.e., salts containing pharmacologically acceptable anions, including, but not limited to, malate, oxalate, chloride, bromide, iodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, isonicotinate, acetate, lactate, salicylate, citrate, tartrate, oleate, tannate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisate, fumarate, gluconate, glucaronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate, and pamoate (i.e., 1,1'-methylene-bis-(2-hydroxy-3-naphthoate)) salts.

[0016]

[0029] As used herein, "TAM" refers to tumor-associated macrophages.

[0030] As used herein, "TGCT" refers to giant cell tumor of tendon sheath.

[0017]

[0031] As used herein, "DTGCT" refers to diffuse giant cell tumor of the tendon sheath.

[0032] As used herein, "GCTTS" refers to giant cell tumor of the tendon sheath.

[0018]

[0033] As used herein, "PVNS" refers to pigmented villonodular synovitis.

[0034] As used herein, "treating" includes any effect, eg, attenuation, reduction, modulation, or elimination, that results in the improvement of a condition, disease, disorder, or the like.

[0019] (0035) A "therapeutically effective amount" includes an amount of a subject compound that elicits the biological or medical response in a tissue, system, animal, or human that is desired by a researcher, veterinarian, physician, or other clinician. A compound described herein, e.g., Compound 1, is administered in a therapeutically effective amount to treat a condition, e.g., TGCT or DTGCT. Alternatively, a therapeutically effective amount of a compound is the amount required to achieve the desired therapeutic and / or prophylactic effect, such as an amount that results in the prevention or reduction of symptoms associated with a condition.

[0020] (0036) The compounds described herein, e.g., Compound 1, can be formulated into pharmaceutical compositions using pharmaceutically acceptable carriers and administered by various routes. In some embodiments, such compositions are for oral administration. In some embodiments, such compositions are for parenteral (injection) administration (e.g., compositions formulated for local injection at the site of a tumor, e.g., diffuse giant cell tumor). In some embodiments, such compositions are for transdermal administration. In some embodiments, such compositions are for intravenous (IV) administration. In some embodiments, such compositions are for intramuscular (IM) administration. Such pharmaceutical compositions and processes for preparing them are well known in the art. See, for example, REMINGTON: THE SCIENCE AND PRACTICE OF PHARMACY (A. Gennaro et al., eds., 19th ed., Mack Publishing Co., 1995).

[0021]

[0037] Throughout this disclosure, various patents, patent applications, and publications are referenced. The disclosures of these patents, patent applications, and publications in their entireties are incorporated by reference into this disclosure to more fully describe the state of the art as known to those of ordinary skill in the art as of the date of this disclosure. In the event of any inconsistency between these patents, patent applications, and publications and this disclosure, the present disclosure shall control.

[0022]

[0038] ChemDraw version 10 or 12 (CambridgeSoft Corporation, Cambridge, Mass.) was used to name the structures of intermediates and exemplified compounds.

[0023] How to use

[0039] Selective inhibitors of CSF1R are described herein, including 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one (i.e., Compound 1) and pharmaceutically acceptable salts thereof. Compound 1 can be represented by the following:

[0024] [ka]

[0025] (0040) The compounds described herein, e.g., Compound 1, may be useful in inhibiting TAM proliferation, depleting TAMs, repolarizing tumor-promoting M2 TAMs to anti-tumor M1 macrophages, and treating the disorders disclosed herein, e.g., related disorders such as diffuse tendon sheath giant cell tumor (DTGCT), in patients, where treatment with Compound 1 causes macrophage depletion in this mesenchymal tumor. In some embodiments, Compound 1 potently inhibits CSF1R signaling. In some embodiments, Compound 1 blocks macrophage-mediated tumor cell migration. In some embodiments, Compound 1 blocks osteoclast differentiation. In some embodiments, Compound 1 blocks the proliferation of CSF1R-dependent cell lines. In some embodiments, Compound 1 potently inhibits CSF1R signaling in cellular assays and blocks macrophage-mediated tumor cell migration, osteoclast differentiation, and the proliferation of CSF1R-dependent cell lines. In some embodiments, the compounds are selective in inhibiting CSF1R over one or more of FLT3, KIT, PDGFRα, PDGFRβ, and VEGFR2 kinases, hi some embodiments, the compounds are more than 100-fold selective in inhibiting CSF1R over FLT3, KIT, PDGFRα, PDGFRβ, and VEGFR2 kinases.

[0026]

[0041] In some embodiments, provided are methods for treating giant cell tumor of tendon sheath in a patient (e.g., a human patient) in need thereof, comprising orally administering to the patient a therapeutically effective amount of the compound 2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one, or a pharmaceutically acceptable salt thereof. In some embodiments, such giant cell tumor of tendon sheath may be localized, for example, as a single, well-defined nodule. In some embodiments, such giant cell tumor of tendon sheath may be a diffuse giant cell tumor of tendon sheath, for example, a benign tumor. In some embodiments, such giant cell tumor of tendon sheath may be a diffuse giant cell tumor of tendon sheath, for example, a diffuse giant cell tumor of tendon sheath with multiple nodules, which is more aggressive. The method may include administering about 2 mg to about 60 mg of a compound (e.g., Compound 1) daily, once a week, twice a week, or three times a week. For example, the disclosed methods, such as methods for treating giant cell tumor of tendon sheath, may include administering about 10 mg to about 90 mg of the disclosed compound daily, twice a week, or three times a week to a patient in need thereof. In some embodiments, the method for treating giant cell tumor of tendon sheath may include administering about 5 mg to about 70 mg of the disclosed compound daily, twice a week, or three times a week to a patient in need thereof. In some embodiments, the method for treating giant cell tumor of tendon sheath may include administering about 5 mg to about 50 mg of the disclosed compound daily, twice a week, or three times a week to a patient in need thereof. In some embodiments, the method for treating giant cell tumor of tendon sheath may include administering about 5 mg to about 30 mg of the disclosed compound daily, twice a week, or three times a week to a patient in need thereof. In some embodiments, the method of treating giant cell tumor of tendon sheath may comprise administering about 6 mg to about 25 mg of the disclosed compound daily, twice a week, or three times a week to a patient in need thereof. In some embodiments, the method of treating giant cell tumor of tendon sheath may comprise administering about 6 mg to about 20 mg of the disclosed compound daily, twice a week, or three times a week to a patient in need thereof.In some embodiments, the method of treating giant cell tumor of tendon sheath may comprise administering about 20 mg to about 50 mg of the disclosed compounds daily, twice a week, or three times a week to a patient in need thereof.

[0027]

[0042] Such disclosed methods may, in embodiments, include administering a loading dose of the compound daily for a first period; and administering a maintenance dose of the compound daily, once weekly, twice weekly, or three times weekly for a second period. For example, the loading dose may be about 10 mg / day to about 80 mg / day, or about 20 mg / day to about 60 mg / day. In some embodiments, the loading dose is about 20 mg / day, about 30 mg / day, about 40 mg / day, about 50 mg / day, or about 60 mg / day. In some embodiments, the maintenance dose of the compound is about 6 mg / day, 7 mg / day, 8 mg / day, 9 mg / day, 10 mg / day, 11 mg / day, 12 mg / day, 13 mg / day, 14 mg / day, 15 mg / day, 16 mg / day, 17 mg / day, 18 mg / day, 19 mg / day, 20 mg / day, 21 mg / day, 22 mg / day, 23 mg / day, 24 mg / day, 26 mg / day, 27 mg / day, 28 mg / day, 29 mg / day, or 30 mg / day.

[0028] (0043) Administration of the maintenance dose may involve administering to the patient about 10 mg to about 60 mg of the compound, e.g., about 10 mg, about 20 mg, about 25 mg, about 30 mg, about 40 mg, or about 50 mg, which may be administered once, twice, or three times per week, respectively. In some embodiments, the maintenance dose may involve administering to the patient about 2 mg to about 40 mg of the compound once per week. In some embodiments, the maintenance dose may involve administering to the patient about 2 mg to about 30 mg of the compound once per week. In some embodiments, the maintenance dose may involve administering to the patient about 2 mg to about 20 mg of the compound once per week. In some embodiments, the maintenance dose may involve administering to the patient about 5 mg to about 40 mg of the compound once per week. In some embodiments, the maintenance dose may involve administering to the patient about 5 mg to about 30 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg to about 20 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 40 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 30 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 20 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 40 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 30 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 20 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 3 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 8 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg of the compound once per week.In some embodiments, the maintenance dose may comprise administering to the patient about 11 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 12 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 13 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 14 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 15 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 16 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 17 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 18 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 19 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 20 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 22 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 24 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 26 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 28 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 30 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 32 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 34 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 36 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 38 mg of the compound once per week, hi some embodiments, the maintenance dose may comprise administering to the patient about 40 mg of the compound once per week.In some embodiments, the maintenance dose may comprise administering to the patient about 42 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 44 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 46 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 48 mg of the compound once per week. In some embodiments, the maintenance dose may comprise administering to the patient about 50 mg of the compound once per week.

[0029] (0044) In some embodiments, the maintenance dose may comprise administering to the patient about 2 mg to about 40 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 2 mg to about 30 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 2 mg to about 20 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg to about 40 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg to about 30 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg to about 20 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 40 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 30 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 20 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 40 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 30 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 20 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 3 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 8 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 11 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 12 mg of the compound twice per week.In some embodiments, the maintenance dose may comprise administering to the patient about 13 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 14 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 15 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 16 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 17 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 18 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 19 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 20 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 22 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 24 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 26 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 28 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 30 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 32 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 34 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 36 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 38 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 40 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 42 mg of the compound twice per week, hi some embodiments, the maintenance dose may comprise administering to the patient about 44 mg of the compound twice per week.In some embodiments, the maintenance dose may comprise administering to the patient about 46 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 48 mg of the compound twice per week. In some embodiments, the maintenance dose may comprise administering to the patient about 50 mg of the compound twice per week.

[0030] (0045) In some embodiments, the maintenance dose may comprise administering to the patient about 2 mg to about 40 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 2 mg to about 30 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 2 mg to about 20 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg to about 40 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg to about 30 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg to about 20 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 40 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 30 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 20 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 40 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 30 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 20 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 3 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 8 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 11 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 12 mg of the compound three times per week.In some embodiments, the maintenance dose may comprise administering to the patient about 13 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 14 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 15 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 16 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 17 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 18 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 19 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 20 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 22 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 24 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 26 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 28 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 30 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 32 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 34 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 36 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 38 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 40 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 42 mg of the compound three times per week, hi some embodiments, the maintenance dose may comprise administering to the patient about 44 mg of the compound three times per week.In some embodiments, the maintenance dose may comprise administering to the patient about 46 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 48 mg of the compound three times per week. In some embodiments, the maintenance dose may comprise administering to the patient about 50 mg of the compound three times per week.

[0031] (0046) The maintenance dose may also be administered once daily. For example, the maintenance dose may comprise administering about 2 mg of the compound to the patient once daily. In some embodiments, the maintenance may comprise administering about 2 mg to about 40 mg of the compound to the patient once daily. In some embodiments, the maintenance may comprise administering about 2 mg to about 30 mg of the compound to the patient once daily. In some embodiments, the maintenance may comprise administering about 2 mg to about 20 mg of the compound to the patient once daily. In some embodiments, the maintenance may comprise administering about 5 mg to about 40 mg of the compound to the patient once daily. In some embodiments, the maintenance may comprise administering about 5 mg to about 30 mg of the compound to the patient once daily. In some embodiments, the maintenance may comprise administering about 5 mg to about 20 mg of the compound to the patient once daily. In some embodiments, the maintenance may comprise administering to the patient about 6 mg to about 40 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 6 mg to about 30 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 6 mg to about 20 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 10 mg to about 40 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 10 mg to about 30 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 10 mg to about 20 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 3 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 5 mg of the compound once daily. In some embodiments, maintenance may involve administering to the patient about 6 mg of the compound once daily. In some embodiments, maintenance may involve administering to the patient about 8 mg of the compound once daily. In some embodiments, maintenance may involve administering to the patient about 10 mg of the compound once daily. In some embodiments, maintenance may involve administering to the patient about 11 mg of the compound once daily.In some embodiments, the maintenance may comprise administering to the patient about 12 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 13 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 14 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 15 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 16 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 17 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 18 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 19 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 20 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 22 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 24 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 26 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 28 mg of the compound once daily. In some embodiments, the maintenance may comprise administering to the patient about 30 mg of the compound once daily. In some embodiments, the maintenance dose may comprise administering to the patient about 32 mg of the compound once daily. In some embodiments, the maintenance dose may comprise administering to the patient about 34 mg of the compound once daily. In some embodiments, the maintenance dose may comprise administering to the patient about 36 mg of the compound once daily. In some embodiments, the maintenance dose may comprise administering to the patient about 38 mg of the compound once daily. In some embodiments, the maintenance dose may comprise administering to the patient about 40 mg of the compound once daily. In some embodiments, the maintenance dose may comprise administering to the patient about 42 mg of the compound once daily. In some embodiments, the maintenance dose may comprise administering to the patient about 44 mg of the compound once daily.In some embodiments, the maintenance dose may comprise administering to the patient about 46 mg of the compound once daily. In some embodiments, the maintenance dose may comprise administering to the patient about 48 mg of the compound once daily. In some embodiments, the maintenance dose may comprise administering to the patient about 50 mg of the compound once daily.

[0032] (0047) In some embodiments, the maintenance dose may comprise administering to a patient about 2 mg to about 40 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to a patient about 2 mg to about 30 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to a patient about 2 mg to about 20 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to a patient about 5 mg to about 40 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to a patient about 5 mg to about 30 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to a patient about 5 mg to about 20 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to a patient about 6 mg to about 40 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to a patient about 6 mg to about 30 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg to about 20 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 40 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 30 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg to about 20 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 3 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 5 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 6 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 8 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 10 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 11 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 12 mg of the compound every other day.In some embodiments, the maintenance dose may comprise administering to the patient about 13 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 14 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 15 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 16 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 17 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 18 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 19 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 20 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 22 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 24 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 26 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 28 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 30 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 32 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 34 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 36 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 38 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 40 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 42 mg of the compound every other day, hi some embodiments, the maintenance dose may comprise administering to the patient about 44 mg of the compound every other day.In some embodiments, the maintenance dose may comprise administering to the patient about 46 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 48 mg of the compound every other day. In some embodiments, the maintenance dose may comprise administering to the patient about 50 mg of the compound every other day. In some embodiments, the first period of time, e.g., during which the loading dose is administered (e.g., daily, every other day, or twice daily), is about 1 or 2 weeks, or 1 to 3 weeks. For example, such a first period of time may be about 4 days, about 5 days, about 6 days, or about 10 days. In some embodiments, the first period of time is about 1 to 6 days. In some embodiments, the first period of time is about 1 to 5 days. In some embodiments, the first period of time is about 1 to 4 days. In some embodiments, the first period of time is about 1 to 3 days. In some embodiments, the first period of time is about 1 to 2 days. In some embodiments, the first period of time is about 1 to 5 weeks. In some embodiments, the first period of time is about 1 to 4 weeks. In some embodiments, the first period of time is about 1 to 3 weeks. In some embodiments, the first period of time is about 1 to 2 weeks.

[0033] (0048) In some embodiments, the loading dose is about 2 mg to about 100 mg of the compound. In some embodiments, the loading dose is about 5 mg to about 90 mg of the compound. In some embodiments, the loading dose is about 10 mg to about 80 mg of the compound. In some embodiments, the loading dose is about 10 mg to about 70 mg of the compound. In some embodiments, the loading dose is about 10 mg to about 60 mg of the compound. In some embodiments, the loading dose is about 10 mg to about 50 mg of the compound. In some embodiments, the loading dose is about 10 mg to about 40 mg of the compound. In some embodiments, the loading dose is about 10 mg to about 30 mg of the compound. In some embodiments, the loading dose is about 10 mg to about 20 mg of the compound. In some embodiments, the loading dose is about 2 mg of the compound. In some embodiments, the loading dose is about 3 mg of the compound. In some embodiments, the loading dose is about 4 mg of the compound. In some embodiments, the loading dose is about 5 mg of the compound. In some embodiments, the loading dose is about 10 mg of the compound. In some embodiments, the loading dose is about 11 mg of the compound. In some embodiments, the loading dose is about 12 mg of the compound. In some embodiments, the loading dose is about 13 mg of the compound. In some embodiments, the loading dose is about 14 mg of the compound. In some embodiments, the loading dose is about 15 mg of the compound. In some embodiments, the loading dose is about 16 mg of the compound. In some embodiments, the loading dose is about 17 mg of the compound. In some embodiments, the loading dose is about 18 mg of the compound. In some embodiments, the loading dose is about 19 mg of the compound. In some embodiments, the loading dose is about 20 mg of the compound. In some embodiments, the loading dose is about 22 mg of the compound. In some embodiments, the loading dose is about 24 mg of the compound. In some embodiments, the loading dose is about 26 mg of the compound. In some embodiments, the loading dose is about 28 mg of the compound. In some embodiments, the loading dose is about 30 mg of the compound. In some embodiments, the loading dose is about 32 mg of the compound. In some embodiments, the loading dose is about 34 mg of the compound. In some embodiments, the loading dose is about 36 mg of the compound. In some embodiments, the loading dose is about 38 mg of the compound.In some embodiments, the loading dose is about 40 mg of the compound. In some embodiments, the loading dose is about 42 mg of the compound. In some embodiments, the loading dose is about 44 mg of the compound. In some embodiments, the loading dose is about 40 mg of the compound. In some embodiments, the loading dose is about 46 mg of the compound. In some embodiments, the loading dose is about 48 mg of the compound. In some embodiments, the loading dose is about 50 mg of the compound.

[0034] (0049) In some embodiments, the loading dose is about 2 mg to about 100 mg of the compound once daily. In some embodiments, the loading dose is about 2 mg to about 100 mg of the compound once daily. In some embodiments, the loading dose is about 5 mg to about 90 mg of the compound once daily. In some embodiments, the loading dose is about 10 mg to about 80 mg of the compound once daily. In some embodiments, the loading dose is about 10 mg to about 70 mg of the compound once daily. In some embodiments, the loading dose is about 10 mg to about 60 mg of the compound once daily. In some embodiments, the loading dose is about 10 mg to about 50 mg of the compound once daily. In some embodiments, the loading dose is about 10 mg to about 40 mg of the compound once daily. In some embodiments, the loading dose is about 10 mg to about 30 mg of the compound once daily. In some embodiments, the loading dose is about 10 mg to about 20 mg of the compound once daily. In some embodiments, the loading dose is about 2 mg of the compound once daily. In some embodiments, the loading dose is about 3 mg of the compound once daily. In some embodiments, the loading dose is about 4 mg of the compound once daily. In some embodiments, the loading dose is about 5 mg of the compound once daily. In some embodiments, the loading dose is about 10 mg of the compound once daily. In some embodiments, the loading dose is about 11 mg of the compound once daily. In some embodiments, the loading dose is about 12 mg of the compound once daily. In some embodiments, the loading dose is about 13 mg of the compound once daily. In some embodiments, the loading dose is about 14 mg of the compound once daily. In some embodiments, the loading dose is about 15 mg of the compound once daily. In some embodiments, the loading dose is about 16 mg of the compound once daily. In some embodiments, the loading dose is about 17 mg of the compound once daily. In some embodiments, the loading dose is about 18 mg of the compound once daily. In some embodiments, the loading dose is about 19 mg of the compound once daily. In some embodiments, the loading dose is about 20 mg of the compound once daily. In some embodiments, the loading dose is about 22 mg of the compound once daily. In some embodiments, the loading dose is about 24 mg of the compound once daily. In some embodiments, the loading dose is about 26 mg of the compound once daily.In some embodiments, the loading dose is about 28 mg of the compound once daily. In some embodiments, the loading dose is about 30 mg of the compound once daily. In some embodiments, the loading dose is about 32 mg of the compound once daily. In some embodiments, the loading dose is about 34 mg of the compound once daily. In some embodiments, the loading dose is about 36 mg of the compound once daily. In some embodiments, the loading dose is about 38 mg of the compound once daily. In some embodiments, the loading dose is about 40 mg of the compound once daily. In some embodiments, the loading dose is about 42 mg of the compound once daily. In some embodiments, the loading dose is about 44 mg of the compound once daily. In some embodiments, the loading dose is about 40 mg of the compound once daily. In some embodiments, the loading dose is about 46 mg of the compound once daily. In some embodiments, the loading dose is about 48 mg of the compound once daily. In some embodiments, the loading dose is about 50 mg of the compound once daily.

[0035] (0050) In some embodiments, the loading dose is about 2 mg to about 100 mg of the compound once per week. In some embodiments, the loading dose is about 2 mg to about 100 mg of the compound once per week. In some embodiments, the loading dose is about 5 mg to about 90 mg of the compound once per week. In some embodiments, the loading dose is about 10 mg to about 80 mg of the compound once per week. In some embodiments, the loading dose is about 10 mg to about 70 mg of the compound once per week. In some embodiments, the loading dose is about 10 mg to about 60 mg of the compound once per week. In some embodiments, the loading dose is about 10 mg to about 50 mg of the compound once per week. In some embodiments, the loading dose is about 10 mg to about 40 mg of the compound once per week. In some embodiments, the loading dose is about 10 mg to about 30 mg of the compound once per week. In some embodiments, the loading dose is about 10 mg to about 20 mg of the compound once per week. In some embodiments, the loading dose is about 2 mg of the compound once per week. In some embodiments, the loading dose is about 3 mg of the compound once per week. In some embodiments, the loading dose is about 4 mg of the compound once per week. In some embodiments, the loading dose is about 5 mg of the compound once per week. In some embodiments, the loading dose is about 10 mg of the compound once per week. In some embodiments, the loading dose is about 11 mg of the compound once per week. In some embodiments, the loading dose is about 12 mg of the compound once per week. In some embodiments, the loading dose is about 13 mg of the compound once per week. In some embodiments, the loading dose is about 14 mg of the compound once per week. In some embodiments, the loading dose is about 15 mg of the compound once per week. In some embodiments, the loading dose is about 16 mg of the compound once per week. In some embodiments, the loading dose is about 17 mg of the compound once per week. In some embodiments, the loading dose is about 18 mg of the compound once per week. In some embodiments, the loading dose is about 19 mg of the compound once a week. In some embodiments, the loading dose is about 20 mg of the compound once a week. In some embodiments, the loading dose is about 22 mg of the compound once a week.In some embodiments, the loading dose is about 24 mg of the compound once per week. In some embodiments, the loading dose is about 26 mg of the compound once per week. In some embodiments, the loading dose is about 28 mg of the compound once per week. In some embodiments, the loading dose is about 30 mg of the compound once per week. In some embodiments, the loading dose is about 32 mg of the compound once per week. In some embodiments, the loading dose is about 34 mg of the compound once per week. In some embodiments, the loading dose is about 36 mg of the compound once per week. In some embodiments, the loading dose is about 38 mg of the compound once per week. In some embodiments, the loading dose is about 40 mg of the compound once per week. In some embodiments, the loading dose is about 42 mg of the compound once per week. In some embodiments, the loading dose is about 44 mg of the compound once per week. In some embodiments, the loading dose is about 40 mg of the compound once per week. In some embodiments, the loading dose is about 46 mg of the compound once a week. In some embodiments, the loading dose is about 48 mg of the compound once a week. In some embodiments, the loading dose is about 50 mg of the compound once a week.

[0036] (0051) In some embodiments, the loading dose is about 2 mg to about 100 mg of the compound twice per week. In some embodiments, the loading dose is about 2 mg to about 100 mg of the compound twice per week. In some embodiments, the loading dose is about 5 mg to about 90 mg of the compound twice per week. In some embodiments, the loading dose is about 10 mg to about 80 mg of the compound twice per week. In some embodiments, the loading dose is about 10 mg to about 70 mg of the compound twice per week. In some embodiments, the loading dose is about 10 mg to about 60 mg of the compound twice per week. In some embodiments, the loading dose is about 10 mg to about 50 mg of the compound twice per week. In some embodiments, the loading dose is about 10 mg to about 40 mg of the compound twice per week. In some embodiments, the loading dose is about 10 mg to about 30 mg of the compound twice per week. In some embodiments, the loading dose is about 10 mg to about 20 mg of the compound twice per week. In some embodiments, the loading dose is about 2 mg of the compound twice per week. In some embodiments, the loading dose is about 3 mg of the compound twice per week. In some embodiments, the loading dose is about 4 mg of the compound twice per week. In some embodiments, the loading dose is about 5 mg of the compound twice per week. In some embodiments, the loading dose is about 10 mg of the compound twice per week. In some embodiments, the loading dose is about 11 mg of the compound twice per week. In some embodiments, the loading dose is about 12 mg of the compound twice per week. In some embodiments, the loading dose is about 13 mg of the compound twice per week. In some embodiments, the loading dose is about 14 mg of the compound twice per week. In some embodiments, the loading dose is about 15 mg of the compound twice per week. In some embodiments, the loading dose is about 16 mg of the compound twice per week. In some embodiments, the loading dose is about 17 mg of the compound twice per week. In some embodiments, the loading dose is about 18 mg of the compound twice per week. In some embodiments, the loading dose is about 19 mg of the compound twice a week. In some embodiments, the loading dose is about 20 mg of the compound twice a week. In some embodiments, the loading dose is about 22 mg of the compound twice a week.In some embodiments, the loading dose is about 24 mg of the compound twice per week. In some embodiments, the loading dose is about 26 mg of the compound twice per week. In some embodiments, the loading dose is about 28 mg of the compound twice per week. In some embodiments, the loading dose is about 30 mg of the compound twice per week. In some embodiments, the loading dose is about 32 mg of the compound twice per week. In some embodiments, the loading dose is about 34 mg of the compound twice per week. In some embodiments, the loading dose is about 36 mg of the compound twice per week. In some embodiments, the loading dose is about 38 mg of the compound twice per week. In some embodiments, the loading dose is about 40 mg of the compound twice per week. In some embodiments, the loading dose is about 42 mg of the compound twice per week. In some embodiments, the loading dose is about 44 mg of the compound twice per week. In some embodiments, the loading dose is about 40 mg of the compound twice per week. In some embodiments, the loading dose is about 46 mg of the compound twice a week. In some embodiments, the loading dose is about 48 mg of the compound twice a week. In some embodiments, the loading dose is about 50 mg of the compound twice a week.

[0037] (0052) The second period, e.g., the period during which the maintenance dose is administered, may be at least about 1 week, or longer, e.g., about 1 month or longer (e.g., about 1 month to about 2 months, about 1 month to about 3 months, about 1 month to about 4 months, about 1 month to about 5 months, about 1 month to about 6 months, about 1 month to about 9 months, 1 month to about 12 months, or longer).

[0038]

[0053] The method includes administering a loading dose daily for a first period of time and a maintenance dose daily for a second period of time. In some embodiments, the first period of time is 1 to 6 days and the second period of time is 1 to 35 days. In some embodiments, the first period of time is 1 to 6 days and the second period of time is 1 to 30 days. In some embodiments, the first period of time is 1 to 6 days and the second period of time is 1 to 25 days. In some embodiments, the first period of time is 1 to 6 days and the second period of time is 1 to 22 days. In some embodiments, the first period of time is 1 to 6 days and the second period of time is 1 to 20 days. In some embodiments, the first period of time is 1 to 5 days and the second period of time is 1 to 35 days. In some embodiments, the first period of time is 1 to 5 days and the second period of time is 1 to 30 days. In some embodiments, the first period is 1 to 5 days, and the second period is 1 to 25 days. In some embodiments, the first period is 1 to 5 days, and the second period is 1 to 22 days. In some embodiments, the first period is 1 to 5 days, and the second period is 1 to 20 days. In some embodiments, the first period is 1 to 4 days, and the second period is 1 to 35 days. In some embodiments, the first period is 1 to 4 days, and the second period is 1 to 30 days. In some embodiments, the first period is 1 to 4 days, and the second period is 1 to 25 days. In some embodiments, the first period is 1 to 4 days, and the second period is 1 to 22 days. In some embodiments, the first period is 1 to 4 days, and the second period is 1 to 20 days. In some embodiments, the first period is 1 to 3 days, and the second period is 1 to 35 days. In some embodiments, the first period is 1 to 3 days, and the second period is 1 to 30 days. In some embodiments, the first period is 1 to 3 days, and the second period is 1 to 25 days. In some embodiments, the first period is 1 to 3 days, and the second period is 1 to 22 days. In some embodiments, the first period is 1 to 3 days, and the second period is 1 to 20 days. In some embodiments, the first period is 1 to 2 days, and the second period is 1 to 35 days.In some embodiments, the first period of time is 1 to 2 days, and the second period of time is 1 to 30 days. In some embodiments, the first period of time is 1 to 2 days, and the second period of time is 1 to 25 days. In some embodiments, the first period of time is 1 to 2 days, and the second period of time is 1 to 22 days. In some embodiments, the first period of time is 1 to 2 days, and the second period of time is 1 to 20 days. In other embodiments, the first period of time and the combined second period of time comprise 20 days. In some embodiments, the first period of time and the combined second period of time comprise 21 days. In some embodiments, the first period of time and the combined second period of time comprise 22 days. In some embodiments, the first period of time and the combined second period of time comprise 23 days. In some embodiments, the first period of time and the combined second period of time comprise 24 days. In some embodiments, the first period of time and the combined second period of time comprise 25 days. In some embodiments, the first period of time and the combined second period of time comprise 26 days. In some embodiments, the first period of time and the combined second period of time comprise 27 days. In some embodiments, the first period of time and the combined second period of time comprise 28 days. In some embodiments, the first period of time and the combined second period of time comprise 29 days. In some embodiments, the first period of time and the combined second period of time comprise 30 days. In some embodiments, the first period of time and the combined second period of time comprise 31 days. In some embodiments, the first period of time and the combined second period of time comprise 32 days. In some embodiments, the first period of time and the combined second period of time comprise 33 days. In some embodiments, the first period of time and the combined second period of time comprise 34 days. In some embodiments, the first period of time and the combined second period of time comprise 35 days. The disclosed methods may be administered for a cycle comprising the first period of time and the second period of time. In some embodiments, the cycle comprises 20 days. In some embodiments, the cycle comprises 21 days, hi some embodiments, the cycle comprises 22 days.In some embodiments, the cycle comprises 23 days. In some embodiments, the cycle comprises 24 days. In some embodiments, the cycle comprises 25 days. In some embodiments, the cycle comprises 26 days. In some embodiments, the cycle comprises 27 days. In some embodiments, the cycle comprises 28 days. In some embodiments, the cycle comprises 29 days. In some embodiments, the cycle comprises 30 days. In some embodiments, the cycle comprises 31 days. In some embodiments, the cycle comprises 32 days. In some embodiments, the cycle comprises 33 days. In some embodiments, the cycle comprises 34 days. In some embodiments, the cycle comprises 35 days. In other embodiments, the method may be administered for 1 to 1200 cycles. In some embodiments, the method may be administered for 10 to 1000 cycles. In some embodiments, the method may be administered for 50 to 800 cycles. In some embodiments, the method may be administered for 70 to 700 cycles. In some embodiments, the method may be administered for 100 to 500 cycles.

[0039] (0054) In some embodiments, the loading dose is administered for 1 to 20 days, and the maintenance dose is administered for 20 to 37,000 days. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for nine days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for ten days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for three days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 10 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for nine days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for ten days, followed by a maintenance dose of 10 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound every other day. The method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for nine days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for ten days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for three days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for nine days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for nine days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises The method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for three days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound three times per week. The method comprises administering a loading dose of 10 mg of the compound daily for four days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for nine days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound three times per week.

[0040] (0055) In some embodiments, the loading dose is administered for 1 to 20 days, and the maintenance dose is administered for 20 to 37,000 days. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 20 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for nine days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for ten days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for three days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for four days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 20 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for five days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for eight days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for nine days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for ten days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 20 days, followed by a maintenance dose of 20 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 .... The method comprises administering a loading dose of 10 mg of the compound every other day for 10 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound every day for 3 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound every day for 4 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound every day for 5 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound every day for 6 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound every day for 7 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for seven days, followed by a maintenance dose of 20 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 20 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for three days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for four days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for five days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for seven days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for eight days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for three days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for four days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for five days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for eight days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 20 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for five days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, The method includes administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method includes administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound once a week. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound twice a week. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound twice a week. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound twice a week. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound twice a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for five days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for four days, followed by a maintenance dose of 20 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for three days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for four days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for five days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for seven days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for eight days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for five days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for eight days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound three times weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound three times weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound three times weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound three times weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound three times a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of the compound. and administering a maintenance dose of 20 mg three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for five days, followed by a maintenance dose of 20 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 20 mg of the compound daily for 3 days. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for four days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for seven days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for eight days, followed by a maintenance dose of 20 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 10 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 20 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 20 mg of the compound three times per week.

[0041] (0056) In some embodiments, the loading dose is administered for 1 to 20 days, and the maintenance dose is administered for 20 to 37,000 days. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 30 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for nine days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for ten days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for nine days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for ten days, followed by a maintenance dose of 30 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for nine days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for ten days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for nine days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for nine days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound once a week. In some embodiments, the method comprises The method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for nine days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for ten days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for four days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for nine days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for ten days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 30 mg of the compound three times per week. daily for four days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for nine days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 30 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 30 mg of the compound three times per week.

[0042] (0057) In some embodiments, the loading dose is administered for 1 to 20 days, and the maintenance dose is administered for 20 to 37,000 days. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 40 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for nine days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for ten days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 40 days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for nine days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for ten days, followed by a maintenance dose of 40 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for nine days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for ten days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for nine days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for nine days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 40 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound once a week. In some embodiments, the method comprises The method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for four days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for nine days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for ten days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 40 mg of the compound three times per week. daily for four days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for nine days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 40 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 40 mg of the compound three times per week.

[0043] (0058) In some embodiments, the loading dose is administered for 1 to 20 days, and the maintenance dose is administered for 20 to 37,000 days. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 40 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for nine days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for ten days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 40 days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for nine days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for ten days, followed by a maintenance dose of 50 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound every other day.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound every other day. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for nine days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for ten days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for nine days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for nine days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 40 days, followed by a maintenance dose of 10 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound once a week.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound once a week. In some embodiments, the method comprises The method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound twice weekly.In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound twice weekly. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 5 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for nine days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 7 mg of the compound daily for ten days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for four days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for nine days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 8 mg of the compound daily for ten days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for three days, followed by a maintenance dose of 50 mg of the compound three times per week. daily for four days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for five days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for six days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for seven days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for eight days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for nine days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 10 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound three times per week.In some embodiments, the method comprises administering a loading dose of 12 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 3 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 4 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 5 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 6 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 7 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 8 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 9 days, followed by a maintenance dose of 50 mg of the compound three times per week. In some embodiments, the method comprises administering a loading dose of 15 mg of the compound daily for 10 days, followed by a maintenance dose of 50 mg of the compound three times per week.

[0044] (0059) In some embodiments, the loading dose is administered for 1 to 20 days, and the maintenance dose is administered for 20 to 37,000 days. In some embodiments, the method includes administering a loading dose of 20 mg of the compound daily for 3 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 20 mg of the compound daily for 4 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 20 mg of the compound daily for 5 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 20 mg of the compound daily for 6 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 20 mg of the compound daily for 7 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method includes administering a loading dose of 20 mg of the compound daily for 8 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 20 mg of the compound daily for 9 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 20 mg of the compound daily for 10 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 30 mg of the compound daily for 3 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 30 mg of the compound daily for 4 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 30 mg of the compound daily for 5 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 30 mg of the compound daily for 6 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 30 mg of the compound daily for 7 days, followed by a maintenance dose of 6 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 30 mg of the compound daily for 8 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 30 mg of the compound daily for 9 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 30 mg of the compound daily for 10 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 40 mg of the compound daily for 3 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 40 mg of the compound daily for 4 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 40 mg of the compound daily for 5 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 40 mg of the compound daily for 6 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 40 mg of the compound daily for 7 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 40 mg of the compound daily for 8 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 40 mg of the compound daily for 9 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 40 mg of the compound daily for 10 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 50 mg of the compound daily for 3 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 50 mg of the compound daily for 4 days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 50 mg of the compound daily for 5 days, followed by a maintenance dose of 6 mg of the compound daily.In some embodiments, the method comprises administering a loading dose of 50 mg of the compound daily for six days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 50 mg of the compound daily for seven days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 50 mg of the compound daily for eight days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 50 mg of the compound daily for nine days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 50 mg of the compound daily for ten days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 60 mg of the compound daily for three days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 60 mg of the compound daily for four days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 60 mg of the compound daily for five days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 60 mg of the compound daily for six days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 60 mg of the compound daily for seven days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 60 mg of the compound daily for eight days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose of 60 mg of the compound daily for nine days, followed by a maintenance dose of 6 mg of the compound daily. In some embodiments, the method comprises administering a loading dose ...

Claims

1. For use in a method of treating giant cell tumor of tendon sheath in a patient in need thereof, a therapeutically effective amount of 【Chemistry 1】 or a pharma- ceutically acceptable salt thereof, wherein the method comprises orally administering to the patient a therapeutically effective amount of the compound or a pharma- ceutically acceptable salt thereof.

2. The composition according to claim 1 , wherein the tendon sheath giant cell tumor is a diffuse type tendon sheath giant cell tumor.

3. The composition of claim 1 , wherein the tumor is benign.

4. 4. The composition of any one of claims 1-3, wherein administering comprises administering 2 mg to 60 mg of the compound daily, once a week, twice a week, or three times a week.

5. 4. The composition of any one of claims 1 to 3, wherein said administering comprises administering 10 mg to 90 mg of said compound daily, once a week, twice a week, or three times a week.

6. The composition of any one of claims 1 to 3, wherein said administering comprises administering 30 mg of said compound twice weekly.

7. Administering administering a loading dose of the compound daily for a first period of time; and The composition of any one of claims 1 to 3, comprising administering a maintenance dose of the compound daily, twice weekly, or three times weekly for a second period of time.

8. The composition of claim 7, wherein the loading dose is 10-80 mg / day.

9. The composition of claim 7 or 8, wherein the loading dose is 20-60 mg / day.

10. The composition of any one of claims 7 to 9, wherein the loading dose is 20 mg / day, 30 mg / day, 40 mg / day, 50 mg / day or 60 mg / day.

11. The composition of any one of claims 7 to 10, wherein the maintenance dose is from 2 mg to 60 mg.

12. The composition of any one of claims 7 to 11, wherein the maintenance dose is 2 mg, 10 mg, 20 mg, 25 mg, 30 mg, 40 mg or 50 mg, each administered two or three times per week.

13. The composition according to any one of claims 7 to 12, wherein the first period of time is one week or two weeks.

14. The composition of any one of claims 7 to 12, wherein the first period of time is 4 days, 5 days, 6 days, or 10 days.

15. The composition according to any one of claims 7 to 14, wherein the second period is from 1 month to 2 months, 3 months or more.

16. The composition of any one of claims 7 to 15, wherein the second period of time is from 1 month to 9 months or more.

17. The composition of any one of claims 7 to 16, wherein said administering further comprises administering an additional loading dose for a third period of time.

18. 20. The composition of claim 17, wherein said administering further comprises administering an additional maintenance dose for a fourth period of time.

19. 18. The composition of claim 16 or 17, wherein the third time period and / or the fourth time period occurs after the first time period and the second time period.

20. The composition of any one of claims 1 to 18, wherein one month or more after administration, the patient has an improved tumor response as measured by CT, MRI and / or RECIST.

21. 20. The composition of any one of claims 1 to 19, wherein the patient has improved range of motion in the joints one month or more after administration.

22. 21. The composition of any one of claims 1 to 20, wherein one month or more after administration, the patient has reduced circulating chemokines / cytokines associated with macrophage infiltration and / or inflammation in the affected joint compared to pre-administration levels.

23. The composition of any one of claims 7 to 22, wherein the size of the tendon sheath giant cell tumor is reduced to 90% to 10% of its size before administration.

24. For the treatment of giant cell tumor of tendon sheath in a patient in need thereof, a compound of the formula: 【Chemistry 2】 or a pharma- ceutically acceptable salt thereof, wherein 2 mg to 60 mg of said compound is orally administered to said patient twice weekly.

25. 25. The composition of claim 24, wherein 5 mg to 30 mg of the compound is administered to the patient twice weekly.

26. 26. The composition of claim 24 or 25, wherein 20 mg of the compound is administered to the patient twice weekly.

27. The composition according to claim 24 or 25, wherein the tendon sheath giant cell tumor is a diffuse type tendon sheath giant cell tumor.

28. The composition of any one of claims 24 to 27, wherein the tumor is benign.

29. For the treatment of giant cell tumor of tendon sheath in a patient in need thereof, a compound of the formula: 【Chemistry 3】 wherein 30 mg of said compound is orally administered to said patient twice weekly.

30. 30. The composition of claim 29, wherein the tumor is benign.

31. The method of any one of claims 24 to 30, wherein the tendon sheath giant cell tumor is further treated surgically in the patient.

32. 32. The composition of claim 31, wherein the compound is administered to a patient as an adjuvant after surgically treating a tendon sheath giant cell tumor in the patient.

33. 32. The composition of claim 31, wherein the compound is administered to a patient as a neoadjuvant prior to surgically treating the patient for giant cell tumor of tendon sheath.

34. The composition of any one of claims 24 to 33, wherein one month or more after administration, the patient has an improved tumor response as measured by CT, MRI and / or RECIST.

35. A composition described in any one of claims 24 to 33, wherein the patient has improved range of motion in the joint one month or more after administration.

36. A composition described in any one of claims 24 to 33, wherein one month or more after administration, the patient has reduced levels of circulating chemokines / cytokines associated with macrophage infiltration and / or inflammation in the affected joint compared to pre-administration levels.

37. The composition of any one of claims 24 to 36, wherein the giant cell tumor of tendon sheath is surgically treated after administering the compound to the patient.

38. The composition of any one of claims 24 to 36, wherein the size of the tendon sheath giant cell tumor is reduced to 90% to 10% of the size before administration of the compound or a pharmacopoeia thereof.

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