Laboratory animal management system and method

Abstract

Provided is a laboratory animal management system. This management system comprises: an information identification unit for identifying laboratory information related to laboratory animals transported to a laboratory location; and a stress value calculation unit for calculating a stress value representing the stress suffered by the laboratory animals during transportation on the basis of the laboratory information, wherein the laboratory information includes at least a portion of the transportation distance across which the laboratory animals are being transported, the transportation time at which the laboratory animals are being transported, the number of laboratory animals being transported simultaneously, the ages of the laboratory animals, and information relating to preliminary procedures which the laboratory animals were subjected to prior to transportation.

Description

[Technical field]

[0001] The present disclosure relates to systems and methods for managing laboratory animals. [Background technology]

[0002] Patent Document 1 discloses a laboratory animal breeding device that can be moved by automobile. This device is equipped with a laboratory animal breeding room and a laboratory animal operating room inside, and can be moved to a desired location for use. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 3-195429 Summary of the Invention [Problem to be solved by the invention]

[0004] For example, when animals are loaded into the mobile breeding apparatus and transported to a research institute, the animals may become ill due to stress caused by the transport. If this happens, even if experiments such as treatment and drug administration are performed on the animals, the credibility of the experimental results may be reduced. Therefore, a technology that can predict the stress of experimental animals during transport is desired. [Means for solving the problem]

[0005] The present disclosure can be realized in the following forms. The laboratory animal management system according to one embodiment of the present disclosure includes an information identification unit that identifies experimental information related to a laboratory animal to be transported to an experimental site, and a stress value calculation unit that calculates a stress value representing stress experienced by the laboratory animal during transportation based on the experimental information, the experimental information including a transportation distance for the laboratory animal, a transportation time for the laboratory animal, the number of the laboratory animals to be transported at the same time, the age of the laboratory animal, The device further comprises a recovery time estimation unit which estimates a recovery time for the experimental animal to recover from stress based on the calculated stress value and the experimental content, and a transportation time determination unit which determines a transportation start time for the experimental animal based on the experimental start date, the estimated recovery time, and the transportation time of the experimental animal.The present disclosure includes the following aspects.

[0006] (1) According to a first aspect of the present disclosure, a management system for laboratory animals is provided, the management system comprising an information identification unit that identifies experimental information on laboratory animals transported to an experimental site, and a stress value calculation unit that calculates a stress value representing stress experienced by the laboratory animals during transportation based on the experimental information, the experimental information including at least a part of a transportation distance over which the laboratory animals are transported, a transportation time over which the laboratory animals are transported, the number of the laboratory animals transported at the same time, the age of the laboratory animals, and information regarding preliminary treatments performed on the laboratory animals before transportation. According to this type of management system, it is possible to predict the stress that the laboratory animals will experience during transportation based on the experimental information. (2) In the management system of the above aspect, the experiment information may include details of an experiment to be performed on the experimental animal, and a recovery time estimation unit may be provided that estimates a recovery time for the experimental animal to recover from stress based on the calculated stress value and the details of the experiment. With this type of management system, the recovery time for the experimental animal to recover can be estimated according to the details of the experiment. (3) In the management system of the above aspect, the recovery time estimation unit may obtain, as the recovery time, a time required for the calculated stress value to decrease to an experimentable stress value determined according to the content of the experiment. With this type of management system, it is possible to obtain a recovery time required for an experiment to be able to be performed according to the content of the experiment. (4) In the management system of the above aspect, the recovery time estimation unit may use a decay function that represents the relationship between the passage of time and the decrease in the stress value to determine the time until the calculated stress value decreases to the testable stress value. With this type of management system, the recovery time can be easily determined. (5) In the management system of the above aspect, the attenuation function may vary depending on at least one of the physical build and age of the experimental animal. According to the management system of this aspect, the recovery time of the experimental animal can be calculated depending on the physical build and age of the experimental animal. (6) In the management system of the above aspect, the stress value calculation unit may correct the stress value in accordance with a cortisol concentration of the experimental animal before the experiment. According to the management system of this aspect, the stress value can be calculated with high accuracy. (7) In the management system of the above aspect, the experiment information may include an experiment start date, and a transport time determination unit may be provided that determines a transport start time for the experimental animal based on the experiment start date, the recovery time, and the transport time of the experimental animal. According to this aspect, the transport start time for the experimental animal can be appropriately determined. In addition to the above-mentioned embodiment as a laboratory animal management system, the present disclosure can also be realized as a laboratory animal management method and a laboratory animal management device. [Brief description of the drawings]

[0007] [Figure 1] FIG. 1 is an explanatory diagram of a management system. [Diagram 2] 1 is a block diagram showing a schematic configuration of a management system. [Diagram 3] 13 is a flowchart of a transportation management process. [Figure 4] FIG. 13 is a diagram showing a table for determining a coefficient kn. [Diagram 5] FIG. 13 is a graph for determining the value Pd. [Figure 6] FIG. 13 is a graph for determining the value Pt. [Figure 7] FIG. 13 is a diagram showing a table for determining values ​​Pg, Pm, and Po. [Figure 8] FIG. 13 is a diagram showing a table for determining values ​​Ps, Pr, and Py. [Figure 9] FIG. 11 is an explanatory diagram showing a method for estimating recovery time. [Figure 10]FIG. 11 is an explanatory diagram showing a method for determining a transportation start time. [Figure 11] 13 is a flowchart of a correction coefficient determination process. [Figure 12] 1 is a graph showing the correspondence relationship between cortisol concentration and stress value. [Figure 13] FIG. 4 is an explanatory diagram of a method for deriving a correction coefficient. [Figure 14] FIG. 11 is an explanatory diagram showing an effect of changing a correction coefficient. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] A. First embodiment: FIG. 1 is an explanatory diagram of a laboratory animal management system 100 as a first embodiment of the present disclosure. The management system 100 receives experimental plan information on an animal experiment from a client terminal 200 via a communication line NT such as the Internet, and determines the start time of transporting the laboratory animals to a client facility 250, which is the experimental site, according to the information. For example, a computer, a smartphone, or a tablet terminal is used as the client terminal 200. For example, various vehicles 300 are used for transportation, such as a mobile animal experiment vehicle equipped with experimental equipment and an animal transport vehicle without experimental equipment. In this embodiment, the laboratory animal is a pig. Note that various animal species such as cows, horses, sheep, dogs, cats, rabbits, mice, and chickens can be used as laboratory animals.

[0009] 2 is a block diagram showing a schematic configuration of the management system 100. The management system 100 is configured by a computer, and includes a CPU 10, a memory 20, a storage device 30, and a communication interface 40. These are connected to each other so as to be able to communicate with each other via a predetermined bus 50. The communication interface 40 functions as an input unit that inputs various types of information and an output unit that outputs the information.

[0010] The CPU 10 loads a predetermined computer program stored in the storage device 30 into the memory 20 and executes it, thereby functioning as an information identifying unit 12, a stress value calculating unit 14, a recovery time estimating unit 16, and a transportation timing determining unit 18. These functional units may be configured by circuits.

[0011] The information identification unit 12 identifies experimental information related to the experimental animal to be transported to the experimental site based on the experimental plan information transmitted from the customer terminal 200. The stress value calculation unit 14 calculates a stress value representing the stress the experimental animal will experience during transportation based on the experimental information. The recovery time estimation unit 16 estimates the recovery time required for the experimental animal to recover from the stress caused by transportation based on the stress value and the experiment content. The transportation timing determination unit 18 determines the start time of transportation of the experimental animal based on the experiment start date, the recovery time, and the transportation time. The processing contents realized by each of these units will be explained below based on the flowchart.

[0012] 3 is a flowchart of the transportation management process executed in the management system 100. This process is started when the management system 100 receives a request for transporting a laboratory animal from the customer terminal 200 via the communication line NT.

[0013] When the transportation management process is started, in step S10, the information identifying unit 12 of the management system 100 acquires the experiment planning information from the customer terminal 200. In this embodiment, the experiment planning information includes, for example, the following information. (i) Information describing the location of the shipment. (ii) The number of experimental animals being transported at the same time. (iii) The age (including age in months and weeks) of the experimental animals being transported. (iv) The physical characteristics of the animal being transported (e.g., length, weight, girth). (v) Information regarding any pre-treatment given to the experimental animals prior to shipment. (vi) Information describing the experiment performed on the laboratory animals. (vii) The start date of the experiment. (viii) The type of animal being transported. (ix) Simultaneous transportation of equipment and facilities.

[0014] The "location of the destination" is, for example, the location of the client facility 250 where the animal experiment is performed, and is expressed by the address or longitude and latitude. The "number of experimental animals to be transported at the same time" is the number of experimental animals to be transported at the same time by the same vehicle 300. The "age" of the experimental animals to be transported includes "age in months" and "age in weeks". The "physique of the experimental animals" is expressed by at least one of the total length, weight, and waist circumference, for example. The "information on preliminary treatment" includes, for example, information such as the presence or absence of genome editing, the name of the medicine administered in advance, and whether or not an electroencephalogram measuring device is embedded. The "type of animals to be transported" may be omitted if the species of experimental animals handled by the management system 100 are limited. As described above, the management system 100 of this embodiment targets pigs. The "equipment or device to be transported at the same time" is the equipment or device to be transported at the same time as the experimental animals by the vehicle 300.

[0015] In step S20, the CPU 10 identifies a transportation route for the experimental animals from the information indicating the destination location among the experimental plan information acquired in step S10 and the location of the origin of the experimental animals, and determines the transportation distance and transportation time according to the transportation route. The transportation route, transportation distance, and transportation time can be determined using a known route search algorithm using map data. The CPU 10 may cause an external server to identify the transportation route and determine the transportation distance and transportation time.

[0016] In step S30, the information identifying unit 12 identifies experimental information related to the experimental animal. In this embodiment, the information identifying unit 12 identifies, as the experimental information, the information included in the experimental plan information acquired in step S10 and the transportation distance and transportation time determined in step S20.

[0017] In step S40, the stress value calculation unit 14 calculates a stress value representing the stress that the experimental animal experiences during transportation based on the experimental information identified in step S30. In this embodiment, the stress value calculation unit 14 calculates the stress value Si based on the following formula (1). The higher the stress value Si, the higher the stress.

[0018] Si=kc×kn×(Pd+Pt+Pg+Pm+Po+Ps+Pr+Py)...(1) however, kc is an arbitrarily determined correction coefficient, and is usually "1.0." kn is a coefficient determined according to the number of experimental animals being transported at the same time. Pd is a value determined according to the transportation distance. Pt is a value determined according to the transportation time. Pg is a value determined depending on whether or not genome editing is performed. Pm is a value determined according to the type of medicine administered in advance. Po is a value that is determined depending on whether or not an electroencephalogram measuring device is embedded. Ps is a value that is determined depending on whether or not the vehicle 300 has soundproofing equipment. Pr is a value determined depending on whether or not the experimental animals are allowed to listen to music during transportation. Py is a value determined depending on whether or not various equipment is transported at the same time as the experimental animals.

[0019] Fig. 4 is a diagram showing a table for determining the coefficient kn. The stress value calculation unit 14 determines the coefficient kn according to the number of laboratory animals to be transported simultaneously, by referring to the table shown in Fig. 4 stored in the storage device 30. As shown in Fig. 4, the coefficient kn becomes larger as the number of animals to be transported simultaneously increases.

[0020] FIG. 5 is a diagram showing a graph for determining the value Pd. The value Pd is determined according to the transport distance of the experimental animal and the age of the experimental animal. The value Pd increases as the transport distance increases and increases as the age decreases. The relationship between the transport distance, age, and value Pd shown in FIG. 5 is stored as a function or map in the storage device 30. The stress value calculation unit 14 determines the value Pd from the transport distance and age of the experimental animal by referring to the function or map stored in the storage device 30.

[0021] FIG. 6 is a diagram showing a graph for determining the value Pt. The value Pt is determined according to the transportation time of the experimental animal and the age of the experimental animal. The value Pt increases as the transportation time increases and increases as the age decreases. The relationship between the transportation time, age, and value Pt shown in FIG. 6 is stored as a function or map in the storage device 30. The stress value calculation unit 14 determines the value Pt from the transportation time and age of the experimental animal by referring to the function or map stored in the storage device 30.

[0022] FIG. 7 is a diagram showing a table for determining the values ​​Pg, Pm, and Po. The stress value calculation unit 14 determines the values ​​Pg, Pm, and Po by referring to the table shown in FIG. 7 stored in the storage device 30. For example, if genome editing is performed on the experimental animal as a preliminary treatment before transportation, the value Pg is determined to a predetermined value ("5" in FIG. 7). If medication is administered as a preliminary treatment, the value Pm is determined according to the type of drug administered (2, 3, or 5 in FIG. 7). If an electroencephalogram measuring device is embedded as a preliminary treatment, the value Po is determined to a predetermined value ("10" in FIG. 7). The values ​​Pg, Pm, and Po are set so that the greater the burden of the preliminary treatment on the experimental animal, the larger the value.

[0023] FIG. 8 is a diagram showing a table for determining the values ​​Ps, Pr, and Py. The stress value calculation unit 14 determines the values ​​Ps, Pr, and Py by referring to the table shown in FIG. 8 stored in the storage device 30. For example, if the transport vehicle 300 is equipped with soundproofing equipment, the value Ps is determined to a predetermined value ("-5" in FIG. 8). If the laboratory animal is to listen to music during transport, the value Pr is set to a predetermined value ("-4" in FIG. 8). If various facilities and devices are to be transported together with the laboratory animal during transport, the value Py is set to a predetermined value ("+10" in FIG. 8). The value P s ,P r ,P y are values ​​relating to comfort during transportation, and are set so that the more uncomfortable the transportation environment is, the larger the value, and the more comfortable the transportation environment is, the smaller the value. The value Pr may be different depending on the music played to the laboratory animals. The value Py may be different between when the equipment is loaded onto the vehicle 300 in advance and when the equipment is loaded onto the vehicle 300 after the laboratory animals are loaded. For example, the value Py may be larger when the equipment is loaded onto the vehicle 300 after the laboratory animals are loaded than when the equipment is loaded onto the vehicle 300 in advance.

[0024] After the stress value calculation section 14 calculates the stress value Si in step S40 in FIG. 3, the recovery time estimation section 16 estimates the recovery time, which is the time it takes for the laboratory animal to recover from the stress, in step S50.

[0025] FIG. 9 is an explanatory diagram showing a method of estimating recovery time in the recovery time estimation unit 16. The storage device 30 stores a decay function that indicates the correspondence between the stress value and the elapsed time. This decay function is a function that reduces the stress value as time passes. The decay function is determined according to at least one of the physical size (total length, weight, waist circumference) and age of the experimental animal. The recovery time estimation unit 16 first refers to the decay function stored in the storage device 30 to obtain the time t0 corresponding to the stress value Si calculated in step S40. Next, the recovery time estimation unit 16 specifies the experimentable stress value corresponding to the experiment content to be performed on the experimental animal. The experimentable stress value for each experiment content is stored in the storage device 30. In FIG. 9, the experimentable stress values ​​corresponding to the experiment A, the experiment B, and the experiment C are respectively shown as values ​​Sa, Sb, and Sc. For example, when the experiment C is performed on the experimental animal, the experimentable stress value is the value Sc. Therefore, the recovery time estimation unit 16 refers to the decay function to obtain the time t1 corresponding to this value Sc. Then, the recovery time ta, which is the time it takes for the stress value to decrease from value Si to value Sc, is calculated from the difference between time t1 and time t0. Once this recovery time ta has elapsed, the experimental animal will be in a stressed state in which it is possible to carry out the corresponding experiment.

[0026] After the recovery time estimation unit 16 estimates the recovery time ta in step S50 of FIG. 3, the transportation timing decision unit 18 decides the transportation start time for starting transportation of the experimental animal in step S60.

[0027] Fig. 10 is an explanatory diagram showing a method for determining the transportation start time in the transportation time determination unit 18. As shown in Fig. 10, the transportation time determination unit 18 determines, as the transportation start time, the day obtained by going back from the experiment start date in the experiment information identified in step S30, through the recovery time estimated in step S50, and the transportation time in the experiment information determined in step S30.

[0028] When the transportation start time of the laboratory animals is determined by the series of processes described above, the management system 100 notifies the customer terminal 200 of that time via the communication line NT, and also notifies the transportation agency that will transport the laboratory animals of the transportation start time, and arranges for the delivery of the laboratory animals. Note that the stress value calculated in step S40 of Fig. 3 and the recovery time estimated in step S50 may also be notified to the customer terminal 200 via the communication line NT.

[0029] In the management system 100 of the first embodiment described above, experimental information is determined from experimental plan information received from the customer terminal 200, and stress experienced by the experimental animals during transportation is predicted based on the experimental information. The experimental information includes the transportation distance over which the experimental animals are transported, the transportation time over which the experimental animals are transported, the number of experimental animals transported at the same time, the ages of the experimental animals, information on the preliminary treatments given to the experimental animals before transportation, and the like, so that the stress experienced by the experimental animals during transportation can be predicted with high accuracy based on this information.

[0030] In addition, in this embodiment, the recovery time for the experimental animal to recover from stress can be estimated based on the predicted stress and the contents of the experiment, so that the date on which the experiment can be started can be easily specified. As a result, it is possible to prevent the experimental animal from being treated or medicated in a stressed state, so that the credibility of the experimental results can be improved. Furthermore, when the organs of the experimental animal are used for regenerative medicine, the organs can be extracted in a state where they are minimally damaged.

[0031] In addition, in this embodiment, the time until the calculated stress value falls to an experimentable stress value determined according to the experiment content is calculated as the recovery time, so that an appropriate recovery time can be calculated according to the experiment content. In particular, in this embodiment, the recovery time is calculated using a decay function that represents the relationship between the passage of time and the fall in the stress value, so that the recovery time can be easily calculated. In addition, in this embodiment, the decay function differs depending on the physique and age of the experimental animal, so that an appropriate recovery time can be calculated according to the physique and age of the experimental animal.

[0032] Furthermore, in this embodiment, the start time of transportation can be appropriately determined based on the experiment start date, recovery time, and transportation time, thereby improving the operating rate of experimental animal production facilities and transportation facilities.

[0033] B. Second embodiment: The configuration of the management system 100 of the second embodiment is the same as the configuration of the management system 100 of the first embodiment. In the second embodiment, the stress value calculation unit 14 shown in Fig. 2 has a function of correcting the stress value. In order for the stress value calculation unit 14 to correct the stress value, the management system 100 executes a correction coefficient determination process described below.

[0034] 11 is a flowchart of the correction coefficient determination process executed by the management system 100. This process is executed prior to the transportation management process shown in FIG.

[0035] First, in step S100, the stress value calculation unit 14 acquires the cortisol concentration of the experimental animal before the experiment, that is, the experimental animal that has been in a stressful state for the experiment after transportation. Cortisol is one of the hormones secreted from the adrenal cortex, and is a hormone whose secretion increases when the animal is under stress. The cortisol concentration can be measured by collecting saliva or blood from the experimental animal.

[0036] In step S110, the stress value calculation section 14 calculates a stress value corresponding to the cortisol concentration obtained in step S100.

[0037] 12 is a graph showing the correspondence relationship between the cortisol concentration and the stress value. This correspondence relationship is stored in advance as a function or a map in the storage device 30. The stress value calculation unit 14 determines the stress value S1 corresponding to the cortisol concentration by referring to the function or map stored in the storage device 30. Note that the correspondence relationship between the cortisol concentration and the stress value may differ depending on the physique and age of the experimental animal.

[0038] In step S120 of FIG. 11, the stress value calculation section 14 derives the correction coefficient kc in the formula (1) shown in the first embodiment based on the stress value S1 obtained in step S110.

[0039] FIG. 13 is an explanatory diagram of a method for deriving the correction coefficient kc. For example, it is assumed that the stress value of an experimental animal whose stress has decreased enough to start experiment C will be the value Sc before the start of the experiment. Therefore, the stress value S1 calculated in step S110 should match the stress value Sc before the execution of experiment C. On the other hand, if the stress value S1 calculated in step S110 is not the stress value Sc as shown in FIG. 13, the stress value calculation unit 14 compares the stress value Sc with the stress value S1, and if the stress value S1 is smaller than the stress value Sc, the correction coefficient kc is reduced. Conversely, if the stress value S1 is larger than the stress value Sc, the correction coefficient kc is increased. Then, in the transportation management process shown in FIG. 3 to be executed next time, the correction coefficient kc is used to calculate the stress value in step S40 and estimate the recovery time in step S50.

[0040] Fig. 14 is an explanatory diagram showing the effect of changing the correction coefficient kc. As shown in Fig. 13, the stress value Sc is compared with the stress value S1, and when the stress value S1 is smaller than the stress value Sc, the stress value calculation unit 14 reduces the correction coefficient kc. Then, the stress value Si calculated by the above formula (1) is multiplied by a correction coefficient kc (e.g., 0.9) smaller than the previous correction coefficient kc (e.g., 1.0), and is calculated as a stress value Si' smaller than the original stress value Si. Then, as shown in Fig. 14, the time t0 used to calculate the recovery period becomes later, and the recovery period ta' until the stress value decreases to the value Sc becomes shorter.

[0041] According to the second embodiment described above, it is possible to accurately correct the stress value by measuring the actual cortisol concentration of the laboratory animal. As a result, it is possible to accurately calculate the recovery period, and therefore the start time of transportation, and it is possible to improve the operating rate of the production facilities and transportation facilities for the laboratory animals.

[0042] C. Other embodiments: (C-1) In the above embodiment, the experimental information includes the transportation distance over which the experimental animals are transported, the transportation time over which the experimental animals are transported, the number of experimental animals transported at the same time, the ages of the experimental animals, and information regarding any preliminary treatments given to the experimental animals prior to transportation, but it is not necessary for all of these to be included, and any part of these may be included.

[0043] (C-2) In the above embodiment, the management system 100 includes the recovery time estimation unit 16 and the transportation time determination unit 18, but may not include the transportation time determination unit 18. In this case, the management system 100 may be operated as a system that estimates a recovery time and notifies the customer terminal 200 of the estimated recovery time via the communication interface 40, or a system that displays the recovery time on a display device. Furthermore, the management system 100 may not include the transportation time determination unit 18 and the recovery time estimation unit 16. In this case, the management system 100 may be operated as a system that calculates a stress value to predict stress that the laboratory animal will experience during transportation, and notifies the customer terminal 200 of the predicted stress via the communication interface 40, or a system that displays the predicted stress on a display device.

[0044] (C-3) In the above embodiment, the attenuation function shown in Fig. 9 is different depending on the physique and age of the experimental animal, but a single attenuation function may be determined regardless of the physique and age. Also, different attenuation functions may be determined not only depending on the physique and age but also on the animal species.

[0045] (C-4) In the above embodiment, the formula (1) for calculating the stress value Si can be modified as appropriate. For example, the value kn may be a term rather than a coefficient. Also, at least one of the values ​​Pd, Pt, Pg, Pm, Po, Ps, Pr, and Py may be a coefficient rather than a term. Also, each coefficient and each term in the above formula (1) is not essential, and some coefficients or terms may be omitted as appropriate.

[0046] The present disclosure is not limited to the above-mentioned embodiment, and can be realized in various configurations without departing from the spirit of the present disclosure. For example, the technical features in the embodiments corresponding to the technical features in each aspect described in the Summary of the Invention column can be appropriately replaced or combined to solve some or all of the above-mentioned problems or to achieve some or all of the above-mentioned effects. Furthermore, if the technical feature is not described as essential in this specification, it can be appropriately deleted. [Explanation of symbols]

[0047] 10 CPU, 12 information identification unit, 14 stress value calculation unit, 16 recovery time estimation unit, 18 transportation time determination unit, 20 memory, 30 storage device, 40 communication interface, 50 bus, 100 management system, 200 customer terminal, 250 customer facility, 300 vehicle

Claims

1. 1. A laboratory animal management system, comprising: an information identification unit that identifies experimental information regarding the experimental animal to be transported to the experimental site; a stress value calculation unit that calculates a stress value representing the stress that the experimental animal experiences during transportation based on the experimental information; Equipped with The experimental information includes a transportation distance for transporting the experimental animals, a transportation time for transporting the experimental animals, the number of the experimental animals transported at the same time, the age of the experimental animals, the content of the experiment to be performed on the experimental animals, and the start date of the experiment; Furthermore, a recovery time estimation unit that estimates a recovery time for the experimental animal to recover from stress based on the calculated stress value and the experiment content; a transportation time determination unit that determines a transportation start time of the experimental animal based on the experiment start date, the estimated recovery time, and the transportation time of the experimental animal; A management system comprising:

2. The management system according to claim 1, The recovery time estimation unit calculates, as the recovery time, the time required for the calculated stress value to decrease to an experimentable stress value determined according to the content of the experiment.

3. The management system according to claim 2, A management system in which the recovery time estimation unit uses a decay function that represents the relationship between the passage of time and the decrease in stress value to determine the time until the calculated stress value decreases to the experimentable stress value.

4. The management system according to claim 3, A management system, wherein the decay function varies depending on at least one of the body size of the experimental animal and the age of the experimental animal.

5. The management system according to any one of claims 1 to 4, A management system in which the stress value calculation unit corrects the stress value according to the cortisol concentration of the experimental animal before the experiment.

6. A management system according to any one of claims 1 to 5, The experimental information further includes information regarding any pre-treatment administered to the experimental animal prior to transport.

7. A method for managing an experimental animal, comprising: a computer identifying experimental information relating to the experimental animal to be transported to the experimental site; A step of the computer calculating a stress value representing the stress experienced by the experimental animal during transportation based on the experimental information; Equipped with The experimental information includes a transportation distance for transporting the experimental animals, a transportation time for transporting the experimental animals, the number of the experimental animals transported at the same time, the age of the experimental animals, the content of the experiment to be performed on the experimental animals, and the start date of the experiment; Furthermore, A step in which the computer estimates a recovery time for the experimental animal to recover from stress based on the calculated stress value and the experiment content; and a step of the computer determining a start time for transporting the experimental animal based on the experiment start date, the estimated recovery time, and the transport time of the experimental animal. Management method.

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