Acidic disinfectant composition and cleaning sheet

Abstract

To provide an acidic sterilizing agent composition that does not influence on the quality of a material of a sterilized surface and has excellent sterilization power free from reduction of active ingredients, and to provide a cleaning sheet.SOLUTION: An acidic sterilizing agent composition contains: persulfuric acid or persulfate as an (A) component; an acid agent as a (B) component, containing at least one kind selected from the group consisting of inorganic acid, organic sulfonic acid and organic phosphonic acid; a surface active agent as a (C) component; and water as a (D) component (where, the (B) component does not contain sulfuric acid). A value of a mass ratio (A) / (C) of the (A) component to the (C) component is 0.5 or more and 200 or less. A cleaning sheet comprising a substrate sheet impregnated with the composition is also provided.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a disinfectant composition and a cleaning sheet that are excellent in antibacterial, antiviral, active oxygen stability, and detergency against bacteria and viruses. Specifically, the present invention relates to a disinfectant composition and a cleaning sheet used for the hygiene management of equipment and utensils in food factories, kitchens, medical facilities, etc. More specifically, the present invention relates to an acidic disinfectant composition and a cleaning sheet that have excellent antibacterial properties against bacteria and fungi.

Background Art

[0002] Disinfectants are used to reduce the risk of food poisoning and the spread of infections and to maintain a good hygienic environment in medical facilities, food factories, kitchen facilities, etc. For disinfection in medical facilities, food factories, and kitchen facilities, disinfectants mainly composed of quaternary ammonium salts are generally used. Furthermore, in order to prevent the growth of microorganisms from the dirt adhering to and remaining on the disinfected surface, a disinfectant composition combining a nonionic surfactant, an anionic surfactant, and an amphoteric surfactant is used for the purpose of imparting detergency.

[0003] However, a disinfectant composition mainly composed of a quaternary ammonium salt has problems of causing corrosion and cracking when the material of the surface to be disinfected is plastic. In addition, the emergence of cationic surfactant-resistant bacteria may be a problem with quaternary ammonium salts, and there is a problem that the remaining bacteria may contaminate food and utensils, causing food spoilage and deterioration of the hygienic environment.

[0004] As a conventional disinfectant cleaner, Patent Document 1 describes a wet wipe containing a quaternary ammonium salt. Cited Document 2 describes a wet wipe containing a quaternary ammonium salt, propynyl butylcarbamate, and polyaminopropyl biguanide. Patent Document 3 describes a virus-killing composition containing persulfate, halide, sulfamic acid, non-reducing organic acid, and acidic phosphate.

Prior Art Documents

Patent Documents

[0005] Patent Document 1 Japanese Patent Application Laid-Open No. 2016-022272 Patent Document 2 Japanese Patent Application Laid-Open No. 2018-188368 Patent Document 3 Japanese Patent Application Laid-Open No. 61-165309 Summary of the Invention Problems to be Solved by the Invention

[0006] However, the wet wipes described in Patent Document 1 to Patent Document 2 exhibit bactericidal properties against bacteria, mold, etc., but when the material of the surface to be disinfected is plastic, there are effects of corrosion and cracking, and there is also a concern about the emergence of cationic surfactant-resistant bacteria. The virus-killing composition described in Patent Document 3 generally assumes a powder, and there is a hassle of dissolving the powder and then immersing it in a wet wipe. In addition, when made into an aqueous solution, the active ingredient of persulfate decreases.

[0007] Therefore, an object of the present invention is to provide an acidic disinfectant composition and a cleaning sheet having excellent disinfecting power with low influence on the material of the surface to be disinfected and no decrease in the active ingredient. Means for Solving the Problems

[0008] In order to solve the above problems, as a result of intensive studies by the present inventors, a disinfectant composition containing persulfuric acid or a persulfate as component (A), an acid agent containing at least one selected from the group consisting of inorganic acids, organic sulfonic acids, and organic phosphonic acids as component (B), a surfactant as component (C), and water as component (D), wherein the value of the mass ratio (A) / (C) of the component (A) to the component (C) is 0.5 or more and 200 or less (however, the component (B) does not contain sulfuric acid), and a cleaning sheet provided with a base sheet impregnated with this can solve the problems that the prior art has had, and the present invention has been completed.

[0009] That is, the present invention is (1) An acidic disinfectant composition containing, as component (A), persulfuric acid or a persulfate, as component (B), an acid agent containing at least one selected from the group consisting of inorganic acids, organic sulfonic acids, and organic phosphonic acids, as component (C), a surfactant, and as component (D), water, wherein the value of the mass ratio (A) / (C) of component (A) to component (C) is 0.5 or more and 200 or less (provided that component (B) does not contain sulfuric acid). (2) The acidic disinfectant composition according to (1), wherein component (A) contains potassium peroxymonosulfate. (3) The acidic disinfectant composition according to (1), wherein component (C) contains at least one selected from the group consisting of amphoteric surfactants and anionic surfactants. (4) The acidic disinfectant composition according to (3), wherein component (C) contains at least one selected from the group consisting of alkanesulfonates and polyoxyalkylene alkyl ether sulfates. (5) The acidic disinfectant composition according to (3), wherein component (C) is an alkylamine oxide. (6) The acidic disinfectant composition according to (1), wherein the pH of the acidic disinfectant composition is 0.5 or more and 3 or less. (7) A cleaning sheet comprising a base material sheet impregnated with the acidic disinfectant composition according to any one of (1) to (6). (8) The cleaning sheet according to (7), wherein the base material sheet contains synthetic fibers, and is impregnated with 100 parts by mass or more and 600 parts by mass or less of the acidic disinfectant per 100 parts by mass of the fibers constituting the base material sheet.

Advantages of the Invention

[0010] The acidic disinfectant composition and the cleaning sheet of the present invention have an excellent disinfecting effect with low impact on the material of the surface to be disinfected and no reduction in the active ingredient.

Modes for Carrying Out the Invention

[0011] The present invention relates to an acidic disinfectant composition and a cleaning sheet containing the above components (A) to (D) as essential components. The acidic disinfectant composition and cleaning sheet of the present invention contain persulfuric acid or a persulfate as component (A). This component (A) mainly contributes to the disinfection effect.

[0012] As component (A), any persulfuric acid or persulfate with a recognized disinfection effect can be used. For example, as persulfates, sodium peroxydisulfate, potassium peroxydisulfate, ammonium peroxydisulfate, sodium hydrogen peroxymonosulfate, potassium hydrogen peroxymonosulfate, ammonium hydrogen peroxymonosulfate, etc. can be mentioned. From a commercial reason and the perspective of bactericidal property, potassium hydrogen peroxymonosulfate is preferred as the persulfate. These oxidizing agents may be used alone or in combination of multiple ones.

[0013] Note that potassium hydrogen peroxymonosulfate is contained as a part of the triple double salt (2KHSO5·KHSO4·K2SO4) composed of potassium hydrogen peroxymonosulfate, potassium bisulfate, and potassium sulfate, and is commercially available under the trade name "Oxone". When component (A) contains potassium hydrogen peroxymonosulfate, it is preferably potassium hydrogen peroxymonosulfate derived from the triple double salt composed of potassium hydrogen peroxymonosulfate, potassium bisulfate, and potassium sulfate. TM The concentration of oxidizing substances such as persulfuric acid can be measured by the iodine titration method.

[0014] <Test method> Weigh an appropriate amount of the test solution, add 10 mL of 20% sulfuric acid and 10 mL of 25% potassium iodide solution, perform titration with a 0.01 mol / L aqueous sodium thiosulfate solution, and take the point where it becomes colorless for 30 seconds as the end point. Calculate the available oxygen concentration from the dropping amount of the 0.01 mol / L aqueous sodium thiosulfate solution until the end point according to the following formula (1). [Calculation formula] Available oxygen concentration (ppm) = (dropping amount (mL) of 0.01 mol / L aqueous sodium thiosulfate solution × 80.00) / test solution amount (g) ····· (1)

[0015] ​The acidic antibacterial composition of the present invention contains, as component (B), an acid agent containing at least one selected from the group consisting of inorganic acids, organic sulfonic acids, and organic phosphonic acids. This component (B) mainly contributes to the stability of component (A).

[0016] Examples of the inorganic acid include sulfuric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, nitric acid, nitrous acid, thiocyanic acid, phosphoric acid, phosphorous acid, hypophosphorous acid, pyrophosphoric acid, tripolyphosphoric acid, tetrapolyphosphoric acid, metaphosphoric acid, pentapolyphosphoric acid, hexametaphosphoric acid, and condensed phosphoric acids such as ultraphosphoric acid.

[0017] Examples of the organic sulfonic acid include xylene sulfonic acids such as methanesulfonic acid, ethanesulfonic acid, propanesulfonic acid, butanesulfonic acid, hexanesulfonic acid, and m-xylene sulfonic acid, toluene sulfonic acids such as p-toluenesulfonic acid, cumene sulfonic acids such as p-cumenesulfonic acid, and benzene sulfonic acids such as methoxybenzenesulfonic acid.

[0018] Examples of the organic phosphonic acid include 1-hydroxyethylidene-1,1-diphosphonic acid, methylenediphosphonic acid, 1,2-ethylenediphosphonic acid, 1-hydroxypropylidene-1,1-diphosphonic acid, 1-hydroxybutylidene-1,1-diphosphonic acid, and 2-phosphonobutane-1,2,4-tricarboxylic acid.

[0019] From the viewpoints of active oxygen stability, antibacterial property, and wiping residue marks after drug use, sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid, methanesulfonic acid, pyrophosphoric acid, metaphosphoric acid, m-xylene sulfonic acid, p-toluenesulfonic acid, cumene sulfonic acid, 1-hydroxyethylidene-1,1-diphosphonic acid, and 2-phosphonobutane-1,2,4-tricarboxylic acid are preferred, sulfuric acid, hydrochloric acid, nitric acid, and phosphoric acid are more preferred, and it is even more preferred to use sulfuric acid.

[0020] The acidic antibacterial composition of the present invention uses a surfactant as the component (C). As long as the effects of the present invention are achieved, any surfactant can be used. For example, amphoteric surfactants, anionic surfactants, cationic surfactants, and nonionic surfactants can be mentioned. In the acidic antibacterial agent composition of the present invention, amphoteric surfactants, anionic surfactants, and nonionic surfactants are preferred, and amphoteric surfactants and anionic surfactants are more preferred. The component (C) affects detergency, drug permeability of non-woven fabrics, wiping residue marks after drug use, material effects, etc.

[0021] When the component (C) is an amphoteric surfactant, for example, alkylaminoacetic acid betaine, alkylamidopropyl betaine, sulfobetaine, alkylamino (mono- or di-) propionate, imidazolinium betaine, alkylamine oxide, alkylaminoethyl glycine, alkyldi(aminoethyl) glycine, glycine n-(3-aminopropyl) C10-16 derivatives, alkylpolyaminoethyl glycine, alkyl β-alanine, alkyldiethanolamine, polyoxyalkylene alkylamine, oxyethylene-added type surfactants of diamines, etc. can be mentioned. Among these, alkylamine oxide is preferred, alkyl dimethylamine oxide having an alkyl group with 6 or more and 18 or less carbon atoms is more preferred, alkyl dimethylamine oxide having an alkyl group with 8 or more and 14 or less carbon atoms is more preferred, and alkyl dimethylamine oxide having an alkyl group with 10 carbon atoms (especially decyl group) is even more preferred. The alkyl group may be branched or linear.

[0022] When the (C) component is an anionic surfactant, for example, fatty acids, alkyl or alkenyl succinic acids, polyoxyalkylene alkyl or alkenyl ether carboxylic acids, alkylol sarcosines, alkyl or alkenyl sulfates, polyoxyalkylene alkyl ether sulfates, polyoxyalkylene alkenyl ether sulfates, amide ether sulfates, alkylbenzene sulfonic acids, olefin sulfonic acids, alkane sulfonic acids, alkyl diphenyl ether disulfonic acids, dialkyl sulfosuccinic acids, polyoxyalkylene alkyl ether sulfosuccinic acid semiesters, acyl tauric acids, alkyl monophosphates, alkyl triphosphates, polyoxyalkylene alkyl ether phosphates, dipolyoxyalkylene alkyl ether phosphates, tripolyoxyalkylene alkyl ether phosphates, tripolyoxyalkylene alkyl ether phosphoric acid, and their alkali metal salts, ammonium salts, etc. may be mentioned. Among these, alkyl sulfates or their salts, polyoxyalkylene alkyl ether sulfates or their salts, alkane sulfonic acids or their salts are preferred, and secondary alkane sulfonic acids or their salts, polyoxyethylene alkyl ether sulfates or their salts are more preferred. As an example, sodium secondary alkane sulfonate is exemplified. These may be used alone or in combination of two or more.

[0023] The above anionic surfactant is a compound in the form of a salt, and can be, for example, alkali metal salts such as sodium and potassium; alkaline earth metal salts such as magnesium; alkanolamine salts such as monoethanolammonium and diethanolammonium.

[0024] The alkyl group of the alkyl sulfate salt is preferably an alkyl group having 8 to 18 carbon atoms. Specific examples of the alkyl sulfate salt include sodium lauryl sulfate and sodium myristyl sulfate. The alkyl group of the alkyl ether sulfate salt is preferably an alkyl group having 10 to 18 carbon atoms. Further, the alkyl ether sulfate salt has an oxyethylene group and / or an oxypropylene group, and the average number of repeating units n of the oxyethylene group is preferably 1 to 5, and the average number of repeating units m of the oxypropion group is preferably 0 to 1. Specific examples of the alkyl ether sulfate salt include sodium polyoxyethylene lauryl ether sulfate.

[0025] For the alkane sulfonate, it is preferable to use an alkane sulfonate having 14 to 18 carbon atoms. Specific examples include sodium secondary alkane (C14 - 17) sulfonate and sodium hydroxyalkane (C14 - 18) sulfonate.

[0026] The alkyl group of the linear alkylbenzene sulfonate is preferably an alkyl group having 8 to 16 carbon atoms. Specific examples of the linear alkylbenzene sulfonate include sodium laurylbenzenesulfonate and sodium tetradecylbenzenesulfonate.

[0027] The alkenyl group of the α-olefin sulfonate is preferably an alkyl group having 8 to 20 carbon atoms. Specific examples of the α-olefin sulfonate include Lipolan LB-440 manufactured by Lion Corporation.

[0028] The alkyl group of the alkyl diphenyl ether sulfonate is preferably an alkyl group having 8 to 18 carbon atoms. Specific examples of the alkyl diphenyl ether sulfonate include Pelec SS-H and Pelec SS-L manufactured by Kao Corporation.

[0029] Sulfosuccinate is an alkyl succinate having a sulfo group, and the alkyl group preferably has 6 to 18 carbon atoms. Specific examples of sulfosuccinate include sodium dioctyl sulfosuccinate, sodium didecyl sulfosuccinate, sodium didodecyl sulfosuccinate, sodium di-2-ethylhexyl sulfosuccinate, and the like.

[0030] The alkyl group of the alkyl ether carboxylate is preferably an alkyl group having 8 to 18 carbon atoms. The alkyl ether carboxylate has an oxyethylene group and / or an oxypropylene group, and the average number of repeating units n of the oxyethylene group is preferably 1 to 10, and the average number of repeating units m of the oxypropylene group is preferably 0 to 1.

[0031] When the component (C) is a cationic surfactant, for example, alkyl(alkenyl)trimethylammonium salts, dialkyl(alkenyl)dimethylammonium salts, alkyl(alkenyl)quaternary ammonium salts, mono- or dialkyl(alkenyl)quaternary ammonium salts containing an ether group or an ester group or an amide group, alkyl(alkenyl)pyridinium salts, alkyl(alkenyl)dimethylbenzylammonium salts, alkyl(alkenyl)isoquinolinium salts, dialkyl(alkenyl)morphonium salts, polyoxyethylene alkyl(alkenyl)amines, alkyl(alkenyl)amine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride, and the like can be mentioned. Among these, alkyltrimethylammonium salts are preferred.

[0032] When the (C) component is a nonionic surfactant, for example, polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether, polyoxyethylene polyoxypropylene alkyl ether (the addition form of ethylene oxide and propylene oxide may be either random or block), polyethylene glycol propylene oxide adduct, polypropylene glycol ethylene oxide adduct, glycerin fatty acid ester or its ethylene oxide adduct, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyl polyglucoside, fatty acid monoethanolamide or its ethylene oxide adduct, fatty acid-N-methylmonoethanolamide or its ethylene oxide adduct, fatty acid diethanolamide (for example, coconut oil fatty acid diethanolamide) or its ethylene oxide adduct, sucrose fatty acid ester, alkyl(poly)glycerin ether, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, fatty acid methyl ester ethoxylate, etc. may be mentioned. Among these, polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether, polyoxyethylene polyoxypropylene alkyl ether (the addition form of ethylene oxide and propylene oxide may be either random or block) are preferable, and polyoxyethylene alkyl ether is more preferable.

[0033] The alkyl group or alkenyl group of polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether and polyoxyethylene polyoxypropylene alkyl ether preferably has 8 to 14 carbon atoms. Further, polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether and polyoxyethylene polyoxypropylene alkyl ether have an oxyethylene group and / or an oxypropylene group, and the average repeat number n of the oxyethylene group is preferably 1 to 30, and the average repeat number m of the oxypropylene group is preferably 0 to 10.

[0034] The above components (A) to (C) may each be a single component, or a combination of a plurality of components may be used.

[0035] The acidic disinfectant composition of the present invention contains water as component (D). As the water, tap water, softened water, pure water, RO water, ion-exchanged water, or distilled water can be used. Examples of tap water include tap water in Arakawa-ku, Tokyo (pH = 7.6, total alkalinity (in terms of calcium carbonate) 40.5 mg / L, German hardness 2.3 °DH (of which calcium hardness is 1.7 °DH and magnesium hardness is 0.6 °DH), chloride ion 21.9 mg / L, sodium and its compounds 15 mg / L, nitrate nitrogen and nitrite nitrogen 1.2 mg / L, fluorine and its compounds 0.1 mg / L, boron and its compounds 0.04 mg / L, total trihalomethane 0.016 mg / L, residual chlorine 0.4 mg / L, organic matter (total organic carbon content) 0.7 mg / L). The water of (D) in the present invention is the remainder with respect to the total amount of the above components (A) to (C), or the remainder with respect to the total amount of components (A) to (C) and other optional components.

[0036] (A) The concentration of the component in the acidic disinfectant composition is not particularly limited as long as the effects of the present invention are achieved. However, from the viewpoints of the disinfecting property, material influence, and active oxygen stability of the acidic disinfectant composition, it is preferably 0.1% by mass or more and 5% by mass or less, more preferably 0.2% by mass or more and 2% by mass or less, and still more preferably 0.3% by mass or more and 1% by mass or less with respect to the total amount of the acidic disinfectant composition. It should be noted that potassium peroxymonosulfate is contained in an amount of 42.8% by mass to about 45% by mass in a triple double salt (2KHSO5·KHSO4·K2SO4) composed of potassium peroxymonosulfate, potassium bisulfate, and potassium sulfate.

[0037] (B) The concentration of the component in the acidic disinfectant composition is not particularly limited as long as the effects of the present invention are achieved. However, from the viewpoints of the disinfecting property and material influence of the acidic disinfectant composition, it is preferably 0.01% by mass or more and 5% by mass or less, more preferably 0.05% by mass or more and 2% by mass or less, and still more preferably 0.1% by mass or more and 1% by mass or less with respect to the total amount of the disinfectant composition.

[0038] (C) The concentration in the acidic disinfectant composition is not particularly limited as long as the effects of the present invention are achieved. However, from the viewpoints of the detergency of the acidic disinfectant composition and the drug permeability into the nonwoven fabric, it is preferably 0.001% by mass or more and 2% by mass or less, more preferably 0.01% by mass or more and 1% by mass or less, and still more preferably 0.02% by mass or more and 0.7% by mass or less, based on the total amount of the acidic disinfectant composition.

[0039] The mass ratio of the component (A) to the component (C) in the acidic disinfectant composition of the present invention is preferably such that the value of (A) / (C) is 0.1 or more and 5000 or less, more preferably 0.2 or more and 1000 or less, still more preferably 0.5 or more and 300 or less, and most preferably 1 or more and 100 or less. When the value of (A) / (C) is less than 0.1, the bactericidal property and stability may not be sufficient, and when it is greater than 5000, the detergency and the drug penetration into the nonwoven fabric may deteriorate.

[0040] In the acidic disinfectant composition of the present invention, if necessary, a pH adjuster, a glycol-based solvent and / or a glycol ether-based solvent, a chelating agent, a pigment, other disinfectants, an antifoaming agent, a fragrance, a corrosion inhibitor, a natural extract, a thickener, an enzyme, and other salt components (such as sodium chloride and mirabilite) can be further blended.

[0041] Examples of the pH adjuster include lithium hydroxide, potassium hydroxide, sodium hydroxide, cerium hydroxide, calcium hydroxide, magnesium hydroxide, barium hydroxide, aluminum hydroxide, sodium carbonate, sodium metasilicate, sodium acetate, potassium phosphate, sodium phosphate, sodium hydrogen phosphate, N,N-dimethylethanolamine, N,N-dibutylethanolamine, N-(β-aminoethyl)ethanolamine, N-methylethanolamine, N-methyldiethanolamine, N-ethylethanolamine, N-ethyldiethanolamine, N-n-butyldiethanolamine, N-t-butyethanolamine, N-t-butyldiethanolamine, N-(β-aminoethyl)isopropanolamine, N,N-diethylisopropanolamine, 2-amino-2-hydroxymethyl-1,3-propanediol, aminomethylpropanol, tetrahydroxypropyl ethylenediamine, morpholine, N-methylmorpholine, N-ethylmorpholine, piperazine, hydroxyethylpiperazine, 2-methylpiperazine, trans-2,5-dimethylpiperazine, cis-2,6-dimethylpiperazine and other alkalis, and acids other than component (B) (for example, acetic acid). These may be used alone or in combination of two or more.

[0042] Examples of the glycol-based solvent include ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, isoprene glycol, 1,2-butylene glycol, 1,3-butylene glycol and the like. These may be used alone or in combination of two or more.

[0043] In addition, examples of glycol ether solvents include ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monohexyl ether, ethylene glycol monophenyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, diethylene glycol monobenzyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, triethylene glycol monopropyl ether, triethylene glycol monobutyl ether, triethylene glycol monohexyl ether, triethylene glycol monophenyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, propylene glycol monobutyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether, dipropylene glycol monobutyl ether, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, diethylene glycol methyl ethyl ether, propylene glycol methyl ethyl ether, dipropylene glycol methyl ethyl ether, and the like. These may be used alone or in combination of two or more.

[0044] Examples of chelating agents include ethylenediaminetetraacetic acid, nitrilotriacetic acid, methylglycine diacetic acid, hydroxyethylenediamine triacetic acid, diethylenetriamine pentaacetic acid, triethylenetetramine hexaacetic acid, hydroxyethyliminodiacetic acid, dihydroxyethylglycine, glutamic acid diacetic acid, aspartic acid diacetic acid, β-alanine diacetic acid, serine diacetic acid, and alkali metal salts thereof. These may be used alone or in combination of two or more.

[0045] Examples of the pigment include natural pigments, synthetic pigments, or mixtures thereof. Examples of other bactericides include sodium hypochlorite, potassium hypochlorite, sodium chlorite, potassium chlorite, sodium chlorate, potassium chlorate, sodium perchlorate, potassium perchlorate, sodium chlorinated isocyanurate, potassium chlorinated isocyanurate, ε-polylysine, poly-γ-glutamic acid, nisin, etc. Examples of the antifoaming agent include silicone-based antifoaming agents, polyether-based antifoaming agents, higher alcohol-based antifoaming agents, etc. Examples of the fragrance include natural fragrances, synthetic fragrances, or compound fragrances thereof. Examples of the corrosion inhibitor include polycarboxylic acids such as short-chain dicarboxylic acids or tricarboxylic acids, phosphate esters, benzotriazole, triazoles such as tolyltriazole or mercaptobenzothiazole, adipic acid, glutaric acid, or succinic acid, silicate, etc. Examples of the natural extract include natural extracts derived from plants such as plants of the Asclepiadaceae family, Rubiaceae family, Brassicaceae family, Poaceae family, Cornaceae family, Asteraceae family, Lamiaceae family, Zingiberaceae family, Camelliaceae family, Solanaceae family, Cupressaceae family, Moraceae family, Vitaceae family, Fabaceae family, Rutaceae family, Liliaceae family, etc., and natural extracts derived from animals such as lysozyme and white shrimp protein extract. Examples of the thickener include carrageenan, xanthan gum, guar gum, locust bean gum, ghatti gum, karaya gum, pectin, etc. Examples of the enzyme include lipase, alkaline amylase, amylase, cellulase, protease, pullulanase, etc.

[0046] From the viewpoint of the stability of the component (A), the pH of the acidic bactericide composition of the present invention is preferably 0.5 or more and 3 or less, more preferably 1 or more and 2.5 or less.

[0047] In the disinfection method using the acidic disinfectant composition of the present invention, the above acidic disinfectant composition may be directly used as a disinfectant solution by applying it to the surface of the object to be disinfected. Alternatively, a method can be adopted where the disinfectant solution is sprayed or discharged onto the object to be disinfected using a foaming washer (spray gun or foam pump), or the object to be disinfected is immersed in the disinfectant solution. Furthermore, it can be impregnated into the base material sheet described below and used as a cleaning sheet.

[0048] (Base material sheet) The cleaning sheet of the present invention includes a base material sheet. The cleaning sheet of the present invention may be a single-layer sheet consisting essentially of only the base material sheet, or may be a laminated sheet of two or more layers formed by laminating the base material sheet and an arbitrary sheet. Also, base material sheets made of different members may be laminated.

[0049] The above base material sheet may be any sheet that can appropriately hold the impregnated acidic disinfectant composition. Specifically, for example, as the base material sheet, non-woven fabrics, woven fabrics, mesh fabrics, etc. made of recycled fibers, synthetic fibers, natural fibers, or mixed fibers thereof can be mentioned.

[0050] From the perspective that the base material sheet becomes hydrophilic, the impregnation amount of the acidic disinfectant composition can be increased, and good antiviral properties can be exhibited, it is preferable that the base material sheet is a sheet containing synthetic fibers. More preferably, the proportion of synthetic fibers is 10% by mass or more based on the total mass of the fibers constituting the base material sheet, still more preferably 50% by mass or more, and even more preferably more than 75% by mass. The impregnation amount of the acidic disinfectant composition into the base material sheet can be in the range of 100 parts by mass or more and 600 parts by mass or less of the acidic disinfectant composition per 100 parts by mass of the fibers constituting the base material sheet. Preferably, it is 150 parts by mass or more and 500 parts by mass or less, and more preferably 200 parts by mass or more and 450 parts by mass or less.

[0051] Regenerated fibers refer to those obtained by dissolving natural polymer compounds into solutions and then spinning them through spinnerets. Examples of natural polymer compounds include cellulose-based materials using cellulose materials such as wood and cotton, and protein-based materials using protein materials such as milk, corn, and peanuts. Examples of regenerated fibers manufactured using cellulose-based materials include rayon, polynosic, cupra, lyocell, and the like. Examples of synthetic fibers include polypropylene, polyester, polyethylene terephthalate, polystyrene, acrylic, and examples of natural fibers include cotton, wool, etc.

[0052] The cleaning sheet of the present invention exhibits excellent bactericidal properties and is also excellent in preventing corrosion of the object to be wiped. Therefore, the present invention is not only used for cleaning various objects to be wiped at home to provide a hygienic environment, but is also useful for disinfection in a wide range of fields such as the medical field, food field, brewing field, and agricultural field. In particular, since the present invention realizes not only bactericidal properties but also the compatibility of the corrosion prevention effect of the object to be wiped, which has been a conventional problem, it is suitable for maintaining the hygienic environment in the medical field and food field where there are many opportunities to clean plastic or stainless steel surfaces.

[0053] The cleaning sheet of the present invention can be applied to various uses. For example, it is suitable for surface disinfection excluding the human skin surface, equipment disinfection, or for disinfection and virus removal around toilets, beds, and water areas such as drain outlets. The cleaning sheet of the present invention can be formed in a form in which a plurality of sheets are laminated, a form in which a long sheet is wound in a roll shape, or a form in which the sheet is folded into an appropriate size.

Examples

[0054] Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples. Each component used in the formulation in the Examples and Comparative Examples is shown below. In the following Examples, etc., "%" represents mass % unless otherwise specified, and the numerical values of the formulations in the Examples and Comparative Examples in the table represent the mass % of the pure component. The "balance" indicating the water content represents the formulation amount adjusted so that the total amount of the aqueous disinfectant, which is the final preparation, becomes 100 mass %. The compounds used in the Examples and Comparative Examples are described below. Regarding the notation of the alkyl group, for example, when it is denoted as alkyl (C8-18), it represents a mixture having an alkyl group with 8 or more and 18 or less carbon atoms.

[0055] Each component of the acidic disinfectant composition (hereinafter abbreviated as the disinfectant composition) used in the formulation in the cleaning sheets of the Examples and Comparative Examples is shown in Tables 1 to 9 below. Also, regarding the base sheet, the ratio (mass %) of each constituent fiber to 100 mass % of the base sheet is shown in Tables 1 to 9. A base sheet of a non-woven fabric containing various fibers at the ratios shown in the table was impregnated so that the disinfectant composition was 350 parts by mass to 450 parts by mass per 100 parts by mass of the base sheet, and stored in a sealed container for 24 hours to be used as a cleaning sheet. Also, each cleaning sheet was tightened with a force of 10 N·cm for 10 minutes using a vise, and the squeezed-out solution was used as the squeezed-out liquid. Using the cleaning sheet and / or the squeezed-out liquid, each measurement and evaluation described below were carried out. The measurement results and evaluation results are shown in Tables 1 to 9.

[0056] (Component (A)) A-1: Potassium peroxymonosulfate (sulfuric acid) (manufactured by Lonza, product name "OXONE" (trademark) (a double salt composed of potassium peroxymonosulfate, potassium bisulfate, and potassium sulfate)) A-2: Potassium peroxydisulfate A-3: Sodium peroxydisulfate A-4: Ammonium peroxydisulfate

[0057] (Component (B)) B-1: Sulfuric acid B-2: Hydrochloric acid B-3: Nitric acid B-4: Phosphoric acid B-5: Methanesulfonic acid B-6: Pyrophosphoric acid B-7: Metaphosphoric acid B-8: m-Xylenesulfonic acid B-9: p-Toluenesulfonic acid B-10: 1-Hydroxyethylidene-1,1-diphosphonic acid B-11: 2-Phosphonobutane-1,2,4-tricarboxylic acid

[0058] (C) component C-1: Octyldimethylamine oxide (manufactured by Global Amines, product name "GENAMINOX OC (trademark)") C-2: Decyldimethylamine oxide (manufactured by Global Amines, product name "GENAMINOX K-10 (trademark)") C-3: Sodium secondary alkane (C14~17) sulfonate (manufactured by Clariant, product name "HOSTAPUR SAS30SB (trademark)") C-4: Sodium polyoxyethylene alkyl ether sulfate (manufactured by Teika, product name: Teikapol NE-7030 (trademark)) C-5: Alkyl (C14~C18) trimethylammonium chloride (manufactured by Lion Specialty Chemicals, product name: Lipocard 16-29 (trademark)) C-6: Polyoxyalkylene alkyl (C9~C11) ether (manufactured by Oxaris Chemicals, product name: JCT ethoxylate 91-6)

[0059] (D) component D-1: Ion-exchanged water

[0060] For the compositions of each example, water of the (D) component was added to the mixing tank so that the total of the composition was 100% by mass, and then the (A) component, (B) component, and (C) component were blended into the mixing tank and sufficiently mixed and stirred for preparation.

[0061] Examples 1 to 59, Comparative Examples 1 to 6 Bactericidal agent compositions shown in Tables 1 to 9 were prepared. Using each bactericidal agent composition, bactericidal property, prevention of metal and plastic corrosion, rinsability, and storage stability were measured. Tables 1 to 5 and 7 to 8 show the results of Examples 1 to 59, and Tables 6 and 9 show the results of Comparative Examples 1 to 6, respectively. Note that Examples 1 to 14, 19, 21 to 31, 35 to 45, 52 to 54, and 56 to 59 are reference examples.

[0062] ※1: Method for measuring pH Connect a combined electrode for pH measurement (manufactured by HORIBA; glass sliding sleeve type) to a pH meter (manufactured by HORIBA; pH / Ion meter F-23) and turn on the power. As the internal solution of the pH electrode, a saturated potassium chloride aqueous solution (3.33 mol / L) was used. Next, fill 100 mL beakers with a pH 4.01 standard solution (phthalate standard solution), a pH 6.86 (neutral phosphate standard solution), and a pH 9.18 standard solution (borate standard solution), respectively, and immerse them in a constant temperature bath at 25 °C for 30 minutes. Immerse the pH measurement electrode in the thermostatically adjusted standard solution for 3 minutes, and perform calibration operations in the order of pH 6.86 → pH 9.18 → pH 4.01. Fill a 100 mL beaker with each bactericidal agent composition and adjust the temperature to 25 °C in a constant temperature bath. Immerse the pH measurement electrode in the thermostatically adjusted sample for 3 minutes and measure the pH of the composition.

[0063] ※2: Evaluation test regarding usability Test method: Using 10 cleaning sheets (200 mm × 250 mm) shown in Tables 1 to 9, take out 1 non-woven fabric impregnated with the chemical solution, and wipe the clean stainless-steel surface over an area of about 30 centimeters square, wiping up and down 5 times and left and right 5 times. The usability was confirmed by a sensory test from the viewpoints of foaming, stickiness, wetness, roughness, and dampness. Also, panelists were randomly selected, and n = 10 was set for each sample. Statistical processing was performed for the analysis of the evaluation results, and the item with the most evaluations was adopted as the evaluation result.

[0064] Evaluation criteria: ○: No foaming, stickiness, watery feeling, or roughness, with appropriate moisture and good usability. △: Slightly foaming, sticky, watery, or rough, or without appropriate moisture. ×: Excessively foaming, sticky, watery, or rough, or almost no moisture and poor usability. And △ and ○ were determined to be practical.

[0065] ※3: Bactericidal test Staphylococcus aureus (NBRC13276) was used as the test strain.

[0066] 3-1: Cultivation of the strain The test strain was smeared on SCD agar medium (Nissui Pharmaceutical Co., Ltd.), cultured at 37°C for 24 hours, and the colonies were scraped off and diluted in sterilized phosphate-buffered saline respectively to be used as the bacterial suspension.

[0067] 3-2: Preparation of sterilized neutralizing solution 10 g of soy lecithin, 30 g of Tween 80, 1 g of L-histidine, and 20 g of sodium thiosulfate were dissolved in 1 L of distilled water by heating, and cooled while stirring. Then, 9 mL of each was dispensed into test tubes with screw caps and sterilized by autoclaving (121°C, 20 minutes) to obtain a sterilized neutralizing solution.

[0068] 3-3: Bactericidal test Test method: 0.1 mL of each bacterial suspension was added to 10 mL of a sterilizing cleaning solution prepared by diluting each bactericidal agent composition to 0.5% by mass with ion-exchanged water so that the final concentration was 1.5 - 5.0×10 8 (CFU / mL), and the mixture was contacted at 20°C for 1 minute to obtain a test solution. 1 mL of each test solution was added to the sterilized neutralizing solution and stirred well. After the mixture was mixed and solidified on SCD agar medium, it was cultured at 37°C for 2 days. After cultivation, the viable bacteria count was measured, and the bactericidal property was evaluated according to the following criteria based on the difference from the initial bacteria count. Those evaluated as △, ○, and ◎ were determined to be practical.

[0069] Evaluation criteria: ◎: Log reduction of the test bacteria is 6 or more ○: Log reduction of the test bacteria is 4 or more and less than 6 △: Log reduction of the test bacteria is 2 or more and less than 4 ×: Log reduction of the test bacteria is less than 2

[0070] ※4: Bactericidal test (spore-forming bacteria) Test method: The test strain was smeared on SCD agar medium (Nissui Pharmaceutical Co., Ltd.) and cultured at 37°C. After culturing, it was confirmed by microscopic observation that spores were sufficiently formed. 10 mL of sterilized pure water was placed on the plate medium, and the colonies were scraped off to collect the suspension. The collected suspension was centrifuged and washed 3 times at 10,000 rpm under the conditions of 4°C for 15 minutes. After centrifugation, an appropriate amount of sterilized pure water was added, and the number of bacteria was adjusted to about 2.0×10 8 ~9.0×10 8 CFU / mL, and heat treatment was carried out in a water bath at 80°C for 15 minutes to obtain a spore-forming bacteria solution.

[0071] 0.1 mL of the test spore-forming bacteria solution was added to 10 mL of each squeezed-out liquid, and after contacting at 20°C for 10 minutes, a sterilized neutralization solution was added and stirred well. Clostridioides difficile ATCC9689 (10 8 CFU / mL level) was used as the spore-forming bacteria. 1 mL of this was mixed and cultured on SCD agar medium to confirm the viable count, and evaluated according to the following criteria.

[0072] Evaluation criteria: 1 point: Reduction in the number of bacteria with a log reduction of the test bacteria of 3 or more 2 points: Reduction in the number of bacteria with a log reduction of the test bacteria of 2 or more and less than 3 3 points: Reduction in the number of bacteria with a log reduction of the test bacteria of less than 2 The reduction in the number of bacteria for each of the above bacterial species was evaluated by points, and the average value of the points of the reduction in the number of bacteria was obtained, and the bactericidal property was evaluated according to the following criteria. ◎: The average value is 1.0 or more and less than 1.5 points. ○: The average value is 1.5 or more and less than 2.0 points. △: The average value is 2.0 or more and less than 2.5 points. ×: The average value is 2.5 or more. And △, ○, and ◎ were determined to be practical.

[0073] ※5: Virus inactivation test (feline calicivirus) <Test method> Add 0.1 mL of feline calicivirus solution (FCV F9 strain) adjusted to 10 8 TCID50 / mL to 0.9 mL of each disinfectant composition in a test tube to prepare a virus test solution (Virus test solution 1), mix with a mixer, and allow to act at 25 °C for 1 minute. Also, assuming organic soil, add 0.1 mL of feline calicivirus solution (FCV F9 strain) containing 0.5% meat extract (manufactured by Nacalai Tesque) adjusted to 10 8 TCID50 / mL to 0.9 mL of each disinfectant composition in a test tube to prepare a virus test solution containing organic soil (Virus test solution 2), mix with a mixer, and allow to act at 25 °C for 1 minute.

[0074] After reacting for 1 minute as described above, dilute Virus test solutions 1 and 2 7-fold with Dulbecco's modified Eagle's Medium (DMEM) supplemented with 2% fetal bovine serum (FBS) to stop the reaction. The stopped solution after the reaction was serially diluted 7-fold with DMEM medium, and each diluted solution was inoculated onto feline kidney cells (CRFK) and cultured in DMEM medium supplemented with 1% FBS in a 37 °C, CO2 incubator for 4 days. After culturing, the cytopathic effect was observed and the virus infectivity titer (TCID50 / mL) was determined. From the initial infectivity titer of the control and the infectivity titer after the action of the test article, the logarithm reduction value of the virus infectivity titer (Virus infectivity Log reduction value) was calculated, and the virus inactivation effect was evaluated according to the following criteria.

[0075] <Evaluation criteria> ◎: The logarithm reduction value of the virus infectivity titer decreases by 4 or more. ○: The logarithmic decrease value of the virus infection titer is a decrease of 3 or more and less than 4. △: The logarithmic decrease value of the virus infection titer is a decrease of 2 or more and less than 3. ×: The logarithmic decrease value of the virus infection titer is a decrease of less than 2. And △, ○, and ◎ were determined to be practical.

[0076] ※6: Test for reducing wiping marks by cleaning sheets A 15 cm × 15 cm glass plate was prepared, and the surface of the glass plate was wiped up and down 5 times and left and right 5 times with each cleaning sheet shown in Tables 1 to 9. Then, the glass plate was dried at room temperature for 2 hours, and the remaining wiping marks generated on the surface of the glass plate were visually evaluated.

[0077] Evaluation criteria: ◎: The remaining wiping marks are not noticeable at all. 〇: The remaining wiping marks are hardly noticeable. △: The remaining wiping marks are slightly noticeable but at an acceptable level. ×: The remaining wiping marks are noticeable. And △, 〇, and ◎ were determined to be practical.

[0078] ※7: Evaluation test on the corrosiveness of the object to be wiped Test method: For each 30 mL of each disinfectant composition, a total of 18 sheets of 9 types of resin and metal panels (vinyl chloride · ABS · polypropylene · polyethylene · acrylic · polycarbonate · silicon · Teflon (registered trademark) · stainless steel) cut into a size of 1 cm × 2.5 cm × 7.5 cm were immersed. After storage at 25°C for 48 hours, each panel was rinsed with ion-exchanged water and dried at room temperature for 24 hours, and then the degree of corrosion was visually evaluated.

[0079] Evaluation criteria: ◎: No discoloration, deterioration, cracks, etc. are observed on all panels. ○: Discoloration, deterioration, cracks, etc. are observed on less than 20% of the panels. △: Discoloration, deterioration, cracks, etc. are observed on 20% or more and less than 30% of the panels. ×: Discoloration, deterioration, cracks, etc. are observed in panels with 3 or more cuts.

[0080] ※8: Evaluation test on drug uneven distribution of base sheet Test method: Non-woven fabrics (200 mm × 250 mm × 300 sheets) made of various materials shown in Tables 1 to 9 were put into a 3 L polypropylene bag, impregnated with 2 L of each disinfectant composition, stored at room temperature for 24 hours, then cut in half lengthwise, and visually observed whether the chemical solution had penetrated to the center part.

[0081] Evaluation criteria: ◎: The chemical solution has penetrated evenly throughout. ○: The chemical solution has penetrated almost entirely. △: There are some parts that have not been penetrated. ×: There are parts that have not been penetrated everywhere. And △, ○, and ◎ were determined to be practical.

[0082] ※9: Evaluation test on discoloration of non-woven fabric Test method: Ten cleaning sheets (200 mm × 250 mm) shown in Tables 1 to 9 were used, stored at 40°C for 1 week, and then the appearance changes of the cleaning sheets were visually observed. Evaluation criteria: ◎: No discoloration or deterioration has occurred. ○: Almost no light discoloration or minor deterioration has occurred. △: Some strong discoloration or strong deterioration has occurred, but it is at a non-problematic level. ×: Overall, strong discoloration or strong deterioration has occurred. And △, ○, and ◎ were determined to be practical

[0083] ※10: Active oxygen stability test Test method: Non-woven fabrics made of PET materials shown in Tables 1 to 9 (200 mm × 250 mm × 300 sheets) were placed in bags made of PET and polyethylene with aluminum vapor deposition, each containing 2 L of each disinfectant composition, impregnated, stored at room temperature for 24 hours, sealed by heat sealing, and the residual active oxygen ratio after being left at 40°C for 1 month was measured. <Test method> Weighed an appropriate amount of the test solution, added 10 mL of 20% sulfuric acid and 10 mL of 25% potassium iodide solution, titrated with 0.01 mol / L sodium thiosulfate aqueous solution, and took the point when it became colorless for 30 seconds as the end point. The active oxygen concentration was calculated from the dropping amount of 0.01 mol / L sodium thiosulfate aqueous solution up to the end point according to the following formula (1). [Calculation formula] Active oxygen concentration (ppm) = (dropping amount of 0.01 mol / L sodium thiosulfate aqueous solution (mL) × 80.00) / test solution amount (g) ····· (1)

[0084] Evaluation criteria: ○: Residual active oxygen ratio is 80% or more △: Residual active oxygen ratio is 60% or more and less than 80% ×: Residual active oxygen ratio is less than 60% We judged △ and ○ as having practicality.

[0085] ※11: Storage stability test Test method: Put 100 g of each disinfectant composition into a polypropylene container, observed the appearance after standing at 0°C, 25°C, and 40°C for 1 month.

[0086] Evaluation criteria: ○: No separation or turbidity is observed and it is stable. △: There is no overall separation, some turbidity is observed, but there is no problem in use. ×: Separation or turbidity is observed. We judged △ and ○ as having practicality.

[0087]

Table 1

[0088] [Table 2]

[0089] [Table 3]

[0090] [Table 4]

[0091] [Table 5]

[0092] [Table 6]

[0093] [Table 7]

[0094] [Table 8]

[0095] [Table 9]

Claims

1. (A) component, persulfuric acid or a persulfate salt; (B) an acid agent including at least one selected from the group consisting of inorganic acids, organic sulfonic acids, and organic phosphonic acids; (C) a surfactant as component; (D) Water as component and a mass ratio (A) / (C) of the component (A) to the component (C) is 0.5 or more and 200 or less (provided that the component (B) does not contain sulfuric acid).

2. The acidic disinfectant composition according to claim 1, wherein the component (A) contains potassium hydrogen peroxomonosulfate.

3. 2. The acidic disinfectant composition according to claim 1, wherein the component (C) contains at least one selected from the group consisting of amphoteric surfactants and anionic surfactants.

4. The acidic disinfectant composition according to claim 3, wherein the component (C) contains at least one selected from the group consisting of alkanesulfonates and polyoxyalkylene alkyl ether sulfates.

5. The acidic disinfectant composition according to claim 3, wherein component (C) is an alkylamine oxide.

6. The acidic disinfectant composition according to claim 1, wherein the pH of the acidic disinfectant composition is 0.5 or more and 3 or less.

7. A cleaning sheet comprising a base sheet impregnated with the acidic disinfectant composition according to any one of claims 1 to 6.

8. 8. The cleaning sheet according to claim 7, wherein the base sheet contains synthetic fibers and is impregnated with 100 parts by mass or more and 600 parts by mass or less of an acidic disinfectant per 100 parts by mass of fibers constituting the base sheet.

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