Liquid Concentration Measuring Device and Extracorporeal Circulation Device

Abstract

To provide a blood concentration measuring device and an extracorporeal circulation device capable of reducing a difference in measured value of the blood concentration due to an individual difference such as a dimension and a shape of a blood storage part.SOLUTION: A liquid concentration measuring device 60 comprises: a liquid storage part 80 fitted to a device main body 70; a sensor part 73 which comprises a light emission part 731 for emitting light to the liquid stored in the liquid storage part 80, and a light reception part 732 which receives light which has transmitted through or reflected by the liquid storage part 80 and liquid stored in the liquid storage part 80; a storage part 75 for storing in advance an initial detection value of the liquid storage part 80 in a state in which no liquid is stored; and a correction control part 744 for, when the liquid is not stored in the liquid storage part 80 and the liquid storage part 80 is fitted to the device main body 70, executing correction operation for adjusting light intensity of the light emitted from the light emission part 731 so as to reduce a difference between the detection value by the light reception part 732 and the initial detection value stored in the storage part 75.SELECTED DRAWING: Figure 4

Description

Technical Field

[0001] The present invention relates to a liquid concentration measuring device and an extracorporeal circulation device including the liquid concentration measuring device.

Background Art

[0002] Conventionally, during dialysis treatment, blood circulating in a blood circuit is temporarily stored in a blood storage unit (liquid storage unit), and a blood concentration measuring device (liquid concentration measuring device) that calculates the blood concentration of the blood temporarily stored in the blood storage unit using a sensor unit (light emitting unit, light receiving unit) is known (see, for example, Patent Document 1). The blood concentration measuring device irradiates light from a light emitting unit onto the blood temporarily stored in the blood storage unit, receives the light reflected by the blood or the light transmitted through the blood with a light receiving unit, and measures and calculates the change in the intensity of the light received by the light receiving unit to calculate the blood concentration of the blood.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] Here, if there are variations in the dimensions, shape, etc. of the blood storage unit, the intensity of the incident light used when calculating the blood concentration will differ from the actual intensity of the incident light on the blood for each blood storage unit used. As a result, due to individual differences such as the dimensions and shape of the blood storage unit, the difference in the measured values of the blood concentration may increase.

[0005] Therefore, an object of the present invention is to provide a liquid concentration measuring device and an extracorporeal circulation device capable of reducing the difference in the measured values of the liquid concentration due to individual differences such as the dimensions and shape of the liquid storage unit.

Means for Solving the Problems

[0006] The present invention relates to a liquid concentration measuring device including: a device main body; a liquid storage unit that is detachably configured on the device main body and can store a liquid; a light emitting unit that emits light toward the liquid storage unit attached to the device main body and the liquid stored in the liquid storage unit; a light receiving unit that receives light transmitted through or reflected by the liquid storage unit and the liquid stored in the liquid storage unit; a storage unit that preliminarily stores an initial detection value which is a detection value by the light receiving unit in an initial state of the liquid storage unit in a liquid non-stored state where no liquid is stored; and a calibration control unit that executes a calibration operation for adjusting the intensity of light emitted from the light emitting unit so as to reduce a difference between a detection value by the light receiving unit and the initial detection value stored in the storage unit when the liquid storage unit is attached to the device main body and no liquid is stored in the liquid storage unit.

[0007] Further, it is preferable that the storage unit stores an attachment determination range of the storage unit which is a range of detection values detected by the light receiving unit when the liquid storage unit is attached to the device main body, and includes a determination unit that determines that the liquid storage unit is attached to the device main body when the detection value by the light receiving unit is within the attachment determination range of the storage unit.

[0008] Further, it is preferable that the storage unit stores a non-liquid storage determination range which is a range of detection values detected by the light receiving unit when no liquid is stored in the liquid storage unit, and includes a determination unit that determines that no liquid is stored in the liquid storage unit when the detection value by the light receiving unit is within the non-liquid storage determination range.

[0009] Further, it is preferable that the calibration control unit does not execute the calibration operation when the liquid storage unit is not attached to the device main body or when liquid is stored in the liquid storage unit.

[0010] The present invention also relates to an extracorporeal circulation device including a blood circuit and the liquid concentration measuring device disposed in the blood circuit.

Effects of the Invention

[0011] According to the present invention, it is possible to provide a liquid concentration measuring device and an extracorporeal circulation device that can reduce the difference in the measured values of the liquid concentration due to individual differences such as the dimensions and shapes of the liquid storage parts.

Brief Description of the Drawings

[0012]

Figure 1

Figure 2

Figure 3

Figure 4

Embodiments for Carrying Out the Invention

[0013] Hereinafter, an embodiment of a hemodialysis device (extracorporeal circulation device) including the blood concentration measuring device (liquid concentration measuring device) of the present invention will be described with reference to the drawings. The hemodialysis device of the present invention purifies the blood of patients with renal failure or drug poisoning, removes excess water in the blood, and replenishes (supplies fluid) water to the blood as necessary.

[0014] First, the overall configuration of the hemodialysis device 1 of the present embodiment will be described with reference to FIG. 1. The hemodialysis device 1 includes a dialyzer 10 as a hemodialyzer, a blood circuit 20, a dialysate circuit 30, a console 100, and a control device 50. A part of the blood circuit 20, a part of the dialysate circuit 30, a chemical solution pump 231, and the control device 50 are arranged in the console 100.

[0015] The dialyzer 10 includes a container body 11 formed in a cylindrical shape and a dialysis membrane (not shown) housed inside the container body 11. The inside of the container body 11 is partitioned by the dialysis membrane into a blood-side flow path and a dialysate-side flow path (both not shown). The container body 11 is formed with a blood inlet 111 and a blood outlet 112 that communicate with the blood-side flow path, and a dialysate inlet 113 and a dialysate outlet 114 that communicate with the dialysate-side flow path.

[0016] The blood circuit 20 includes an arterial line 21, a venous line 22, a drug line 23, and an overflow line 24. The arterial line 21, the venous line 22, the drug line 23, and the overflow line 24 are all mainly composed of flexible tubes through which liquid can flow.

[0017] One end of the arterial line 21 is connected to the artery of the subject (dialysis patient), and the other end is connected to the blood inlet 111 of the dialyzer 10. An air bubble sensor 211, a blood pump 212, and a blood concentration measuring device 60 (liquid concentration measuring device) are arranged on the arterial line 21. The air bubble sensor 211 detects air bubbles contained in the blood flowing inside the arterial line 21. The blood pump 212 is arranged downstream of the air bubble sensor 211 in the arterial line 21. The blood pump 212 squeezes the tube constituting the arterial line 21 to send out the blood inside the arterial line 21.

[0018] The blood concentration measuring device 60 is arranged between the blood pump 212 and the dialyzer 10 in the arterial line 21. As shown in FIG. 2, the blood concentration measuring device 60 includes a sensor clip 70 (device body) and a blood chamber 80 (liquid storage part) detachably attached to the sensor clip 70. The blood concentration measuring device 60 can calculate the hematocrit value and the oxygen saturation by once storing the blood flowing through the arterial line 21 of the blood circuit 20 in the blood chamber 80 and measuring the concentration of the blood components in the blood flowing through the arterial line 21 of the blood circuit 20 in real time. The blood concentration measuring device 60 will be described in detail later.

[0019] As shown in FIG. 1, one end of the venous line 22 is connected to the blood outlet 112 of the dialyzer 10, and the other end is connected to the vein of the subject (dialysis patient). A venous pressure sensor 221, a venous chamber 222, a bubble sensor 223, and a venous clamp 224 are arranged on the venous line 22.

[0020] The venous pressure sensor 221 detects the pressure of the blood flowing through the venous line 22. The venous chamber 222 is arranged on the downstream side of the venous pressure sensor 221 in the venous line 22. The venous chamber 222 stores a predetermined amount (for example, 20 ml) of blood. The bubble sensor 223 is arranged on the downstream side of the venous chamber 222 in the venous line 22. The bubble sensor 223 detects the bubbles contained in the blood flowing through the inside of the venous line 22. The venous clamp 224 is arranged on the downstream side of the bubble sensor 223 in the venous line 22. The venous clamp 224 opens and closes the flow path of the venous line 22.

[0021] The drug line 23 supplies the drugs necessary during hemodialysis to the arterial line 21. One end (proximal end) of the drug line 23 is connected to a drug solution pump 231 that delivers the drug, and the other end (distal end) is connected between the blood pump 212 and the blood concentration measuring device 60 in the arterial line 21.

[0022] One end (proximal end) of the overflow line 24 is connected to the venous chamber 222. The overflow line 24 discharges physiological saline, air, etc. flowing through the venous line 22 to the outside during the priming process. An overflow clamp 241 is arranged on the overflow line 24. The overflow clamp 241 opens and closes the flow path of the overflow line 24.

[0023] According to the above blood circuit 20, the blood taken out from the artery of the subject (dialysis patient) flows through the arterial line 21 by the blood pump 212 and is introduced into the blood side flow path of the dialyzer 10. The blood introduced into the dialyzer 10 is purified by the dialysate flowing through the dialysate circuit 30 described later via the dialysis membrane. The blood purified in the dialyzer 10 flows through the venous line 22 and is returned to the vein of the subject.

[0024] In this embodiment, the dialysate circuit 30 is constituted by a so-called closed volume control type dialysate circuit 30. This dialysate circuit 30 includes a dialysate chamber 31, a dialysate supply line 32, a dialysate introduction line 33, a dialysate derivation line 34, a drainage line 35, a bypass line 36, and a dehydration / ultrafiltration pump 37.

[0025] The dialysate chamber 31 includes a rigid container 311 capable of accommodating a fixed volume (for example, 300 ml to 500 ml) of dialysate, and a flexible diaphragm 312 partitioning the inside of the container 311. The inside of the dialysate chamber 31 is partitioned by the diaphragm 312 into a liquid supply accommodating portion 313 and a drainage accommodating portion 314.

[0026] The base end side of the dialysate supply line 32 is connected to a dialysate supply device (not shown), and the distal end side is connected to the dialysate chamber 31. The dialysate supply line 32 supplies dialysate to the liquid supply accommodating portion 313 of the dialysate chamber 31.

[0027] The dialysate introduction line 33 connects the dialysate chamber 31 and the dialysate inlet 113 of the dialyzer 10, and introduces the dialysate accommodated in the liquid supply accommodating portion 313 of the dialysate chamber 31 into the dialysate side flow path of the dialyzer 10.

[0028] The dialysate derivation line 34 connects the dialysate outlet 114 of the dialyzer 10 and the dialysate chamber 31, and derives the dialysate discharged from the dialyzer 10 to the drainage accommodating portion 314 of the dialysate chamber 31. The drainage line 35 has its proximal end connected to the dialysate chamber 31 and discharges the dialysate stored in the drainage storage section 314.

[0029] The bypass line 36 connects the dialysate derivation line 34 and the drainage line 35. The ultrafiltration / reverse osmosis pump 37 is arranged in the bypass line 36. The ultrafiltration / reverse osmosis pump 37 is composed of a pump that can be driven to pump the dialysate inside the bypass line 36 in the direction of flowing to the drainage line 35 side (ultrafiltration direction) and the direction of flowing to the dialysate derivation line 34 side (reverse osmosis direction).

[0030] The control device 50 is composed of an information processing device (computer) and controls the operation of the hemodialysis device 1 by executing a control program. Specifically, the control device 50 controls the operations of various pumps, clamps, etc. arranged in the blood circuit 20 and the dialysate circuit 30 to execute various processes (operation (dialysis) process, cleaning process, priming process, blood removal process, fluid infusion process, blood return process, etc.) performed by the hemodialysis device 1.

[0031] Further, the control device 50 monitors the rate of change in circulating blood volume based on the hematocrit value and oxygen saturation calculated from the concentration of blood components in the blood flowing through the arterial side line 21 of the blood circuit 20 measured by the blood concentration measuring device 60 described later, analyzes the precursor of blood pressure drop, and notifies the outside that it is a precursor of blood pressure drop, for example, by a display device or the like.

[0032] In addition, the control device 50 controls the blood concentration measuring device 60. As shown in FIG. 3, the control device 50 has a calibration instruction unit 51. The calibration instruction unit 51 instructs a calibration control unit 744 (described later) of the blood concentration measuring device 60 to execute a calibration operation of the blood concentration measuring device 60. The calibration instruction unit 51 instructs the blood concentration measuring device 60 to execute a calibration operation at a predetermined timing in a state where no blood is stored in the blood chamber 80 of the blood concentration measuring device 60 (a state where the blood chamber 80 is empty). Examples of the predetermined timing in the state where the blood chamber 80 of the blood concentration measuring device 60 is empty and no blood is stored include the timing when the console 100 is started and the timing before the priming process is executed.

[0033] The blood concentration measuring device 60 will be described. The blood concentration measuring device 60 is a device that measures the hematocrit value and oxygen saturation of the blood flowing through the arterial line 21 of the blood circuit 20 during hemodialysis. The blood concentration measuring device 60 measures the concentration of blood components in the blood flowing through the arterial line 21, calculates the hematocrit value and oxygen saturation, and monitors the change rate of the circulating blood volume, thereby analyzing the precursor of blood pressure drop.

[0034] As shown in FIG. 2, the blood concentration measuring device 60 includes a sensor clip 70 (device main body) and a blood chamber 80 (liquid storage unit).

[0035] The blood chamber 80 is detachably attached to the sensor clip 70. The sensor clip 70 includes a first cell holding unit 71, a second cell holding unit 72, and a sensor unit 73 having a light emitting unit 731 and a light receiving unit 732. A light emitting element is provided in the light emitting unit 731. A light receiving element is provided in the light receiving unit 732.

[0036] The first cell holding part 71 and the second cell holding part 72 are arranged to face each other with a chamber accommodation space S therebetween. The first cell holding part 71 and the second cell holding part 72 sandwich and hold the blood chamber 80 in a state where the blood chamber 80 is disposed in the chamber accommodation space S.

[0037] Inside the first cell holding part 71, the light emitting part 731 of the sensor part 73 is arranged. Inside the second cell holding part 72, the light receiving part 732 of the sensor part 73 is arranged. The light emitting part 731 and the light receiving part 732 are arranged to face each other.

[0038] The light emitting part 731 irradiates light toward the blood chamber 80 in a state where the sensor clip 70 sandwiches the blood chamber 80. The light emitting part 731 emits light toward the blood chamber 80 attached to the sensor clip 70 and the blood accommodated in the blood chamber 80. From the light emitting part 731, a plurality of wavelength lights are irradiated to the blood chamber 80 and the blood flowing through the blood chamber 80. The light receiving part 732 receives the light transmitted through the blood chamber 80 and the blood accommodated in the blood chamber 80. By the light receiving part 732 receiving the light transmitted through the blood, the blood concentration measuring device 60 can measure the concentration of blood components due to the difference in the transmittance of red blood cells and moisture in the blood.

[0039] The blood chamber 80 constitutes a blood accommodation cell (liquid accommodation part) having a cell for accommodating blood (liquid) inside. The blood chamber 80 has a container body 81 for accommodating blood, a blood introduction connection part 82, and a blood derivation connection part 83 (see FIG. 1).

[0040] The outer shape of the container body 81 is formed in a disk shape having a thickness. Inside the container body 81, a flow path through which blood flows is formed. The container body 81 is detachably attached to the sensor clip 70 between the light emitting part 731 and the light receiving part 732 of the sensor clip 70. The container body 81 is configured to transmit the light from the light emitting part 731.

[0041] The blood introduction connection part 82 is an introduction part for introducing blood into the blood concentration measurement device 60. The blood introduction connection part 82 is connected to the downstream end of the line connecting the blood pump 212 and the blood concentration measurement device 60 in the arterial side line 21 (see Fig. 1).

[0042] The blood derivation connection part 83 is a derivation part for deriving the blood that has flowed through the inside of the blood concentration measurement device 60 toward the dialyzer 10. The blood derivation connection part 83 is connected to the upstream end of the line connecting the blood concentration measurement device 60 and the dialyzer 10 in the arterial side line 21.

[0043] As shown in Fig. 3, in addition to the above configuration, the sensor clip 70 includes a sensor clip side control part 74 (control part) and a sensor clip side storage part 75 (storage part). The sensor clip side storage part 75 stores in advance the initial detection value of the non-blood-containing state of the blood chamber 80, the blood chamber mounting determination range (accommodation part mounting determination range), and the non-blood-containing state determination range (non-liquid-containing determination range) of the blood chamber 80.

[0044] The initial detection value of the non-blood-containing state of the blood chamber 80 is the initial detection value of the blood chamber 80 detected by the light receiving part 732 of the sensor part 73 in the non-blood-containing state where no blood is accommodated. The initial detection value of the non-blood-containing state of the blood chamber 80 is measured at the time of shipment at the factory, for example, using the blood chamber 80 as a predetermined reference device.

[0045] The blood chamber mounting determination range is the range of the detection value detected by the light receiving part 732 of the sensor part 73 when the blood chamber 80 is mounted on the sensor clip 70. When the determination part 743 (described later) of the sensor clip side control part 74 determines that the detection value by the light receiving part 732 of the sensor part 73 is within the blood chamber mounting determination range, it is determined that the blood chamber 80 is mounted on the sensor clip 70. The blood chamber mounting determination range is obtained in advance by experiments or the like, for example.

[0046] The blood non-accommodation state determination range is the range of the detection value detected by the light receiving unit 732 of the sensor unit 73 when the blood chamber 80 is empty, i.e., not accommodating blood. When the determination unit 743 (described later) of the sensor clip side control unit 74 determines that the detection value by the light receiving unit 732 of the sensor unit 73 is within the blood non-accommodation state determination range, it is determined that the blood chamber 80 is in an empty state without blood being accommodated. The blood non-accommodation state determination range is obtained, for example, through experiments in advance.

[0047] As shown in FIG. 3, the sensor clip side control unit 74 includes a light emission control unit 741, an arithmetic unit 742, a determination unit 743, and a calibration control unit 744.

[0048] The light emission control unit 741 controls the intensity of the light emitted from the light emission unit 731. The arithmetic unit 742 calculates the intensity of the light received by the light receiving unit 732 as a detection value. Thereby, in the blood concentration measuring device 60, when the blood chamber 80 is attached to the sensor clip 70, the hematocrit value and the oxygen saturation are calculated from the detection value detected by the light receiving unit 732 of the sensor unit 73. The calculated hematocrit value and oxygen saturation are transmitted to the control device 50 of the console 100.

[0049] When the detection value by the light receiving unit 732 of the sensor unit 73 is within the blood chamber attachment determination range, the determination unit 743 determines that the blood chamber 80 is attached to the sensor clip 70. When the detection value by the light receiving unit 732 of the sensor unit 73 is within the blood non-accommodation state determination range, the determination unit 743 determines that the blood chamber 80 is in an empty state without blood being accommodated.

[0050] When the determination unit 743 determines that the blood chamber 80 is attached to the sensor clip 70 and no blood is contained in the blood chamber 80, the calibration control unit 744 executes a calibration operation to adjust the intensity of the light emitted from the light emitting unit 731 of the sensor unit 73 so as to reduce the difference between the detection value by the light receiving unit 732 of the sensor unit 73 and the initial detection value of the blood-uncontained state of the blood chamber 80 stored in the sensor clip side storage unit 75.

[0051] More specifically, when the detection value by the light receiving unit 732 of the sensor unit 73 is smaller than the initial detection value of the blood-uncontained state of the blood chamber 80 stored in the sensor clip side storage unit 75, the calibration control unit 744 executes a calibration operation to increase the intensity of the light emitted from the light emitting unit 731 of the sensor unit 73. When the detection value by the light receiving unit 732 of the sensor unit 73 is larger than the initial detection value of the blood-uncontained state of the blood chamber 80 stored in the sensor clip side storage unit 75, the calibration control unit 744 executes a calibration operation to decrease the intensity of the light emitted from the light emitting unit 731 of the sensor unit 73.

[0052] The calibration control unit 744 does not execute the calibration operation when the blood chamber 80 is not attached to the sensor clip 70 or when blood is contained in the blood chamber 80.

[0053] Next, the control of the calibration operation of the hemodialysis device 1 will be described with reference to the flowchart of FIG. 4. In the stage before performing the calibration operation, the initial detection value of the blood-uncontained state of the blood chamber 80 is measured, for example, at the time of shipment from the factory and stored in the sensor clip side storage unit 75.

[0054] In step S1 shown in FIG. 4, the calibration instruction unit 51 of the control device 50 of the console 100 instructs the calibration operation of the blood concentration measuring device 60. The calibration instruction unit 51 instructs the calibration control unit 744 of the blood concentration measuring device 60 to execute the calibration operation at the timing when the blood chamber 80 of the blood concentration measuring device 60 is in an empty state where no blood is contained. As a predetermined timing when the blood chamber 80 of the blood concentration measuring device 60 is in an empty state where no blood is contained, for example, the timing when the console 100 is started or the timing before the priming process is executed can be mentioned.

[0055] In step S2, the determination unit 743 determines whether it is within the blood chamber mounting determination range stored in the sensor clip side storage unit 75, and also determines whether the detection value by the light receiving unit 732 of the sensor unit 73 is within the blood non-accommodation state determination range. When the detection value by the light receiving unit 732 of the sensor unit 73 is within the blood chamber mounting determination range, the determination unit 743 determines that the blood chamber 80 is mounted on the sensor clip 70, and when the detection value by the light receiving unit 732 of the sensor unit 73 is within the blood non-accommodation state determination range, it determines that the blood chamber 80 is in an empty state where no blood is contained.

[0056] When it is determined by the determination unit 743 that the blood chamber 80 is mounted on the sensor clip 70 and the blood chamber 80 is in an empty state (YES), the process proceeds to step S3. When it is determined by the determination unit 743 that the blood chamber 80 is not mounted on the sensor clip 70 or the blood chamber 80 is in a state where blood is contained (NO), the process proceeds to step S4.

[0057] In step S3, the calibration control unit 744 executes a calibration operation to adjust the intensity of the light emitted from the light emitting unit 731 of the sensor unit 73 so as to reduce the difference between the detection value by the light receiving unit 732 of the sensor unit 73 and the initial detection value of the blood-unaccommodated state of the blood chamber 80 stored in the sensor clip side storage unit 75. Thereby, even if there are individual differences in the dimensions and shape of the blood chamber 80, the calibration control unit 744 executes the calibration operation, so that the difference in the measured value of the blood concentration due to the individual differences in the dimensions and shape of the blood chamber 80 can be reduced. After step S3, the process ends.

[0058] In step S4, the calibration control unit 744 does not execute the calibration operation. In step S5, it notifies the outside that the calibration operation is not executed, and then the process ends. Thereby, the calibration control unit 744 can prohibit the calibration operation when it is in a state where the calibration operation cannot be executed. Therefore, it is possible to prevent the calibration operation from being executed under incorrect conditions. Examples of the notification means include display on the display unit, lighting or blinking of an indicator lamp, and reporting from a speaker.

[0059] According to the blood concentration measuring device 60 of the present embodiment described above, the following effects can be obtained.

[0060] The blood concentration measuring device 60 includes a sensor unit 73 having a light emitting unit 731 that emits light toward a blood chamber 80 attached to a sensor clip 70 and blood accommodated in the blood chamber 80, and a light receiving unit 732 that receives light transmitted through the blood chamber 80 and the blood accommodated in the blood chamber 80, a sensor clip side storage unit 75 that stores in advance an initial detection value in the state where the blood chamber 80 is not filled with blood, and a calibration control unit 744 that executes a calibration operation to adjust the intensity of the light emitted from the light emitting unit 731 so as to reduce the difference between the detection value by the light receiving unit 732 and the initial detection value in the state where the blood chamber 80 is not filled with blood stored in the sensor clip side storage unit 75 when the blood chamber 80 is attached to the sensor clip 70 and the blood chamber 80 is not filled with blood. Thereby, even if there are individual differences in the dimensions and shape of the blood chamber 80, the calibration control unit 744 executes the calibration operation, so that the difference in the measurement value of the blood concentration due to individual differences in the dimensions and shape of the blood chamber 80 can be reduced.

[0061] In the present embodiment, the determination unit 743 can determine that the blood chamber 80 is attached to the sensor clip 70 when the detection value by the light receiving unit 732 is within the accommodation unit attachment determination range. Thereby, it can be easily determined that the blood chamber 80 is attached to the sensor clip 70.

[0062] In the present embodiment, the determination unit 743 can determine that the blood chamber 80 is not filled with blood when the detection value by the light receiving unit 732 is within the non-blood-filled determination range. Thereby, it can be easily determined that the blood chamber 80 is not filled with blood.

[0063] In the present embodiment, the calibration control unit 744 does not execute the calibration operation when the blood chamber 80 is not attached to the sensor clip 70 or when the blood chamber 80 contains blood. Thereby, the calibration control unit 744 can prohibit the calibration operation when it is in a state where the calibration operation cannot be executed. Therefore, it is possible to prevent the calibration operation from being executed under incorrect conditions. Further, the calibration control unit 744 can notify the outside when the blood chamber 80 is not attached to the sensor clip 70 or when the blood chamber 80 contains blood.

[0064] In the present embodiment, the hemodialysis device 1 is configured to include a blood circuit 20 and a blood concentration measuring device 60 disposed in the blood circuit 20. Thereby, in the hemodialysis device 1, it is possible to instruct the execution of the calibration operation of the blood concentration measuring device 60. Therefore, since the user does not have to manually perform calibration at an arbitrary timing, the burden on the user can be reduced.

[0065] As described above, the preferred embodiments of the blood concentration measuring device 60 and the hemodialysis device 1 of the present invention have been described. However, the present invention is not limited to the above-described embodiments and can be appropriately modified.

[0066] For example, in the above embodiment, the blood storage unit detachably attached to the sensor clip 70 is configured by the blood chamber 80 including a cell for storing blood therein, but is not limited thereto. The blood storage unit may be configured by a tube through which blood flows.

[0067] Also, in the above embodiment, the sensor clip side control unit 74 is provided in the blood concentration measuring device 60, but is not limited thereto. The function of the sensor clip side control unit 74 may be provided in the control device 50 of the console 100.

[0068] Also, in the above embodiment, the light receiving unit 732 of the sensor unit 73 is configured to detect the light transmitted through the blood, but is not limited thereto. The light receiving unit 732 of the sensor unit 73 may be configured to detect the light reflected by the blood.

[0069] Also, in the above embodiment, the calibration operation of the blood concentration measuring device 60 is configured to be executed by a calibration instruction from the calibration instruction unit 51 of the control device 50 of the console 100, but it is not limited thereto. The calibration operation of the blood concentration measuring device 60 may be configured to be executed by directly operating the blood concentration measuring device 60.

[0070] Also, in the above embodiment, the configuration for determining that the blood chamber 80 is attached to the sensor clip 70 is realized by determining whether or not the detection value by the light receiving unit 732 of the sensor unit 73 is within the accommodation unit attachment determination range, but it is not limited thereto. The configuration for determining that the blood chamber 80 is attached to the sensor clip 70 may be realized by detecting, for example, whether or not there is mechanical, electrical, or magnetic contact when the blood chamber 80 is attached to the sensor clip 70.

[0071] Also, in the above embodiment, the case where blood is stored in the liquid storage unit has been described, but it is not limited thereto, and it may be applied to the case where dialysate is stored in the liquid storage unit.

[0072] Also, in the above embodiment, in the sensor unit 73, the light emitting unit 731 is provided in the first cell holding unit 71 and the light receiving unit 732 is provided in the second cell holding unit 72, but it is not limited to this. Conversely, the light emitting unit 731 may be provided in the second cell holding unit 72 and the light receiving unit 732 may be provided in the first cell holding unit 71.

Explanation of Reference Numerals

[0073] 1 Hemodialysis device (extracorporeal circulation device) 20 Blood circuit 60 Blood concentration measuring device (liquid concentration measuring device) 70 Sensor clip (device main body) 73 Sensor unit 74 Sensor clip side control unit (control unit) 75 Sensor clip side storage unit (storage unit) 80 Blood chamber (liquid storage unit) 731 Light emitting unit 732 Light receiving unit 743 determination unit 744 calibration control unit

Claims

1. A device main body, a liquid storage part that is detachably configured on the device main body and can store a liquid, a light emitting part that emits light toward the liquid storage part attached to the device main body and the liquid stored in the liquid storage part, and a light receiving part that receives light transmitted through or reflected by the liquid storage part and the liquid stored in the liquid storage part, a sensor part having; a storage part that stores in advance an initial detection value that is a detection value by the initial light receiving part of the liquid storage part in a liquid-unstored state where no liquid is stored; a calibration control part that executes a calibration operation for adjusting the intensity of light emitted from the light emitting part so as to reduce the difference between the detection value by the light receiving part and the initial detection value stored in the storage part when the liquid storage part is attached to the device main body and no liquid is stored in the liquid storage part; and is provided with, the storage part stores a storage part mounting determination range that is a range of detection values detected by the light receiving part when the liquid storage part is attached to the device main body, A liquid concentration measuring device comprising a determination part that determines that the liquid storage part is attached to the device main body when the detection value by the light receiving part is within the storage part mounting determination range.

2. A device main body, a liquid storage part that is detachably configured on the device main body and can store a liquid, a light emitting part that emits light toward the liquid storage part attached to the device main body and the liquid stored in the liquid storage part, and a light receiving part that receives light transmitted through or reflected by the liquid storage part and the liquid stored in the liquid storage part, a sensor part having; a storage part that stores in advance an initial detection value that is a detection value by the initial light receiving part of the liquid storage part in a liquid-unstored state where no liquid is stored; a calibration control part that executes a calibration operation for adjusting the intensity of light emitted from the light emitting part so as to reduce the difference between the detection value by the light receiving part and the initial detection value stored in the storage part when the liquid storage part is attached to the device main body and no liquid is stored in the liquid storage part; and is provided with, the storage part stores a liquid-unstored determination range that is a range of detection values detected by the light receiving part when no liquid is stored in the liquid storage part, A liquid concentration measuring device comprising a determination part that determines that no liquid is stored in the liquid storage part when the detection value by the light receiving part is within the liquid-unstored determination range.

3. The liquid concentration measuring device according to claim 1 or 2, wherein the calibration control unit does not execute the calibration operation when the liquid storage unit is not attached to the apparatus main body or when the liquid storage unit stores liquid.

4. A blood circuit, An extracorporeal circulation device comprising the liquid concentration measuring device according to any one of claims 1 to 3 disposed in the blood circuit.

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