Two-component disinfectant system having a color-changing indicator

Abstract

The disinfectant system of the present invention comprises a first component having a first reagent in a carrier and a second component miscible with the first component and having a second reagent in a carrier. Upon mixing, the first and second reagents react to produce a chlorine dioxide disinfectant composition. The first or second component further comprises an anthocyanin dye, an anthocyanidin dye, or a betanin dye that oxidizes in the presence of chlorine dioxide and exhibits a visible color change upon mixing of the first and second reagents. This color change does not occur when the dye-containing component is exposed to a disinfectant composition containing hydrogen peroxide and / or peracetic acid.

Description

Technical Field

[0001] a. Field of the Invention The present invention relates to disinfectant systems, particularly systems for producing chlorine dioxide using a two-component chemical system. A particular use of the present invention is the disinfection of medical devices and their surfaces, particularly surfaces under clinical conditions, but the present invention is not limited thereto.

Background Art

[0002] b. Related Art Two-component disinfectant systems that generate chlorine dioxide upon mixing are known. Such systems generally have chlorite and an acid, or chlorate, a reducing agent, and an acid.

[0003] WO 2005 / 011756 discloses a two-component disinfection system (see FIG. 1). This disinfection system 6 has a first component having a first reagent in a carrier, and a second component that is miscible with the first component and has a second reagent in the carrier. When mixed, the first reagent and the second reagent react to generate a disinfection composition. The first component can be dispensed as a fluid, preferably as bubbles, by placing it in a pump dispenser 2, and the second component can be absorbed or impregnated (soaked) in at least one fabric member in a sealed container 4. To prepare a disinfection tissue, the user removes the impregnated tissue from the container and adds a portion of the bubbles from a nebulizer to the tissue. To facilitate mixing of the bubbles and the reagents in the tissue, the user may fold the tissue in half and crush or rub it before unfolding the folded tissue.

[0004] WO 2005 / 107823 discloses a system suitable for the reprocessing of non-routine medical devices using a disinfection process involving three hand wipes (see Figure 2). The system shown as an example includes a box 10 having a box 14 with a sachet 8 of pre-clean wipes, a disinfection system 6 as described above, and a bag 12 of sterilized rinse wipes. The pre-clean wipes are used to wipe the instrument such as an endoscope to be decontaminated. The instrument is sterilized or disinfected using a two-component disinfection system 6 (with active bubbles combined with the wipes), and if there are chemical residues, they are removed using the sterilized rinse wipes. All details of the disinfection are recorded in an attached audit trail book, enabling complete tracking of the disinfection process.

[0005] WO 2006 / 079822 A1 discloses another disinfection system. In this case, each of the first reagent and the second reagent is carried on an aqueous carrier, and a bubble promoter is added to this carrier so that the first and second components of the system can be dispensed as the first bubbles and the second bubbles respectively. The first bubbles and the second bubbles mix to generate a disinfection composition. Next, the composition may be used to directly disinfect or treat the instrument or surface to be disinfected using a tissue.

[0006] To fully exert the efficacy of disinfectant wipes / wipes and other chlorine dioxide-based disinfection systems, it is desirable to ensure the generation of chlorine dioxide and for the end user to be able to reliably confirm the generation effect of chlorine dioxide.

[0007] It has been proposed to incorporate a pH-sensitive indicator that changes color or is colored when sufficient mixing of one of these components occurs. The problem with this method is that the pH change is not large or does not show a highly reliable correlation with the generation of sufficient chlorine dioxide.

[0008] As the medical industry develops, there is increasing pressure to transition to automated disinfection systems that ensure the successful completion of the disinfection process. The arguments in support of these systems primarily focus on the ability to eliminate or reduce the likelihood of user error and the ability to issue digital tickets at the end of the machine cycle.

[0009] Currently available technologies include test strips, odor detection, titration, and spectrophotometry. While all of these can determine chlorine dioxide concentration, they are limited by measurement accuracy (some methods are semi - quantitative), the need for laboratory facilities, and the adverse impact on the natural process flow of device processing.

Summary of the Invention

[0010] Aspects of the present invention are as described in the independent claims, and preferred features are as described in the dependent claims. By incorporating a suitable dye into one of the parts of the two - component system of this system, it is possible to visually or by means of optoelectronic means confirm that chlorine dioxide can be generated at an effective level in the two - component system prior to sterilization or disinfection. Also, by checking whether discoloration occurs spatially uniformly throughout the carrier, it can be confirmed that chlorine dioxide has been generated throughout the carrier of the two - component system.

[0011] A suitable dye is one that oxidizes in the presence of chlorine dioxide and exhibits a visible color change upon mixing of the first and second reagents, but does not exhibit the same color change upon exposure to a disinfection composition having hydrogen peroxide and / or peracetic acid. Preferably, this dye does not exhibit the same color change upon exposure to a disinfection composition having a quaternary ammonium compound and / or triamines.

[0012] The dyes used in the embodiments of the present invention are thus selective for chlorine dioxide. That is, this discoloration does not occur in the presence of other commonly used high-level disinfectants and bactericides. Thus, the present invention provides protection against the incorrect use of a disinfection system, for example when there is a risk that one or more other disinfectant products are incorrectly used instead of one of the liquids of the system.

[0013] Anthocyanin dyes and anthocyanidin dyes are suitable dyes for use in the present invention. Betanin dyes are also dyes that can be suitably used.

[0014] In the case of suitable anthocyanin dyes, it is also possible to refer to them as E163 food additives. This dye may also be an anthocyanin dye selected from the group consisting of, for example, black carrot extract, purple carrot extract, haskap berry extract and blackcurrant extract. In a particularly preferred embodiment, the dye is Black Carrot Extract, an anthocyanin dye (which can also be referred to as Antho Black Carrot Extract or AnthoCarrot). Examples of suitable anthocyanidin dyes for use include bilberry extract and blue pea extract (Clitoria ternatea). Suitable betanin dyes may also be referred to as E162 food additives. Examples of suitable betanin dyes for use include beetroot powder and beetroot juice concentrate.

[0015] For the dyes in the present invention, it is preferred that they change from colored to colorless in the presence of chlorine dioxide. In this case, it is preferred that the liquid of the system containing the dye exhibits a clear pre-exposure colour of the dye, which disappears after the effective mixing of the two components.

[0016] The first reagent may contain a metal chlorite or metal chlorate, and the second reagent may contain an acid. The dye can be incorporated into the first component, or the second component, or both components.

[0017] The first and second components of the disinfection system can each take any form and are compatible with one another. Generally, the first component may be, for example, a liquid, a foam, or a powder, and can be impregnated in a wipe or carried by other means. The second component may also be, for example, a liquid, a foam, or a powder, and can be absorbed in, impregnated in, or carried by a wipe by other means. The disinfection composition of the present invention is ready for use without the need for dilution after mixing the two components. Alternatively, it may be concentrated and then diluted after mixing to obtain a concentration suitable for use.

[0018] In one embodiment, the first component is contained in a dispenser and can be dispensed as a fluid, particularly as a liquid or a foam, and the second component is absorbed or impregnated in at least one cloth wipe. In this case, since the second component has a dye, discoloration can be more easily observed when treating the wipe with the first component.

[0019] Also, in the use of carrying the dye-containing component on a wipe, the discoloration that occurs upon exposure to chlorine dioxide is more difficult to confirm than in the use of carrying the dye-containing component in other forms such as a liquid. Therefore, in the use of a wipe, the dye shows a strong and distinct coloration, forming a significant contrast to the base color of the wipe (usually white) and / or the yellow color of chlorine dioxide. Anthocyanin, anthocyanidin, and betanin dyes generally exhibit a dark color characteristic of the red / violet / blue region of the spectrum, and thus exhibit a clearly distinguishable discoloration, particularly in the use of carrying the dye-containing component by a wipe. For example, in the case of black carrot extract, it has been recognized as particularly effective in exhibiting a remarkable pre-reaction color when treating the wipe.

[0020] In another embodiment, the first component and / or the second component have bubbles. Similarly in this case, for the dye, it is preferable that due to the light scattering effect, a strong and distinct coloration that can be easily visually recognized is exhibited in the bubbles that are usually white in the absence of the dye. Incidentally, the dark colors characteristic of anthocyanin dyes, anthocyanidin dyes, and betanin dyes are particularly advantageous.

[0021] Each of the first component or the second component may contain about 0.01% to about 2% of the dye. After mixing the first reagent and the second reagent, it is preferable that almost all of the dye is oxidized by the generated chlorine dioxide.

[0022] The present invention can be extended to a method for confirming that a chlorine dioxide disinfecting composition has been generated using the above disinfectant system. In this method, after mixing the first component and the second component, at the time of mixing the first component and the second component, the above-mentioned color change is observed, and it is determined that the chlorine dioxide disinfecting composition has been generated when this color change has ended and is spatially uniform. The color change may be visually observed or can be confirmed by a photoelectronic system. It is also possible to perform the observation / judgment step using a suitable machine vision system.

[0023] In a method for determining whether a wipe in a disinfection system contains chlorine dioxide, at least one wavelength of light is irradiated onto an area of at least one side of a cloth wipe, reflected from the area of at least one side of the cloth wipe, and the intensity of at least one wavelength of light corresponding to the wavelength absorbed by the dye is measured. This intensity value is compared with a preset threshold value. If the intensity value is equal to or greater than the threshold value, it is signaled that the wipe contains sufficient chlorine dioxide. Or if the intensity value is less than the threshold value, it is signaled that the wipe contains insufficient chlorine dioxide. The corresponding apparatus has a device for measuring the intensity value of at least one wavelength of light corresponding to the wavelength absorbed by the dye from at least one surface area of the wipe, a comparator device for comparing this intensity value with a preset threshold value, and a signal device for signaling that the wipe contains sufficient chlorine dioxide if the intensity value is equal to or greater than the threshold value, or signaling that the wipe contains insufficient chlorine dioxide if the intensity value is less than the threshold value.

[0024] In one embodiment, the present invention provides a disinfection system having a first component having a first reagent in a carrier, and a second component that is mixed with the first component and has a second reagent in a carrier. When the first component and the second component are mixed, the first reagent and the second reagent react to produce a chlorine dioxide-based disinfection composition. The first component or the second component further has an anthocyanin dye, an anthocyanidin dye, or a betanin dye.

[0025] Regarding the preferred and / or appropriately adoptable features of each aspect and embodiment of the present invention, they can be used alone in other aspects and embodiments, or can be used in appropriate combinations.

Prior Art Documents

Patent Documents

[0026]

Patent Document 1

Patent Document 2

[0027] [Non-Patent Document 1] Mo et al., “Kinetics of the Preparation of Chlorine Dioxide by Sodium Chlorite and Hydrochloric Acid at Low Concentration”, Chemical Engineering Transactions (46) 49 - 54 2015 [Brief Explanation of Drawings]

[0028] Hereinafter, the present invention will be further described with reference to the attached drawings for illustrative purposes only.

Figure 1-2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

BEST MODE FOR CARRYING OUT THE INVENTION

[0029] The conventional systems shown in FIGS. 1 and 2 can be preferably used in the present invention. However, in the first embodiment, it is different from the conventional system in that the second component further has an anthocyanin dye.

[0030] In this example, the first component has less than 1% sodium chlorite and less than 2.5% amphoteric surfactant. The balance is deionized water. Unless otherwise specified, all "parts" in this specification are by weight. By operating the pump trigger, the first component is dispensed as bubbles.

[0031] The wipe 16 is impregnated with an aqueous acid solution (second component). In this example, the aqueous acid solution has 1 - 5% citric acid and 1% Antho Black Carrot Extract as an anthocyanin dye. The remainder is deionized water.

[0032] The above anthocyanin dye colors the unique color of the cloth wipe 16 (FIG. 3). In this embodiment, the wipe 16 exhibits a pinkish red color before the addition of the first component. The inventor has found that the anthocyanin dye is easily oxidized to a non - colored substance in the presence of chlorine dioxide. As a result, the wipe 16 loses its unique color. This system clearly indicates this when chlorine dioxide is generated, and the end - user can confirm the generation effect of chlorine dioxide.

[0033] Using a stable and selective dye can confirm not only the presence of chlorine dioxide but also, incidentally, the exact level of chlorine dioxide to ensure efficacy. This dye becomes an environmental risk mitigator when the product is used outside its recommended temperature range. The theoretical basis is that the chlorine dioxide generation rate slows down as the temperature gets lower and speeds up as the temperature gets higher. The dye oxidation rate is proportional to the generation level of chlorine dioxide.

[0034] Various dyes were investigated for their ability to exhibit selectivity towards chlorine dioxide. Furthermore, regarding the safety profile of each dye, it was necessary to evaluate whether the generation of harmful by-products, which have the potential to have a harmful effect on patient safety during the oxidation process, could be reliably suppressed.

[0035] For example, potassium iodide exhibits a detectable color change upon oxidation in the presence of chlorine dioxide, but it also exhibits the same color change towards other commonly used oxidative disinfectants such as hydrogen peroxide. Therefore, potassium iodide is non-selective towards chlorine dioxide and is not suitable for use in the present invention. Metal-based pigments are not easily oxidized by chlorine dioxide and are generally not suitable for use either.

[0036] As a result of the research investigation, it was found that anthocyanin dyes, anthocyanidin dyes, and betanin dyes easily exhibit oxidizability, selectivity, and safety, and thus are suitably usable in a chlorine dioxide disinfection system.

[0037] Anthocyanins such as AnthoCarrot are a family of natural pigments that often produce the red-blue colors found in fruits and vegetables. These compounds are not only present in many agricultural products but are also easily found in foods used as natural dyes and food additives. The reference code for food anthocyanins is the E-number E163, and examples include E163(ii) grape skin extract (Enociania Eno), E163(iii) blackcurrant extract, E163(iv) purple corn color, E163(v) red cabbage color, E163(vi) black carrot extract, E163(vii) purple sweet potato color, E163(viii) red radish color, E163(ix) elderberry color, and E163(x) hibiscus color, etc.

[0038] Regarding anthocyanins, there is no toxicological information or warnings, and they are generally considered safe for use.

[0039] Anthocyanin (AnthoCarrot) is red when formulated into the phase 2 liquid solution (i.e., the second aqueous acid component of the disinfection system), and oxidizes to colorless when active in the phase 1 bubbles (i.e., bubbles containing the sodium chlorite-containing first component). To evaluate the degree of oxidation of anthocyanin, post-activation spectrophotometric analysis was performed using 0.5% anthocyanin (AnthoCarrot) of the two liquid solutions in the activated (mixed) and non-activated (before mixing) phases.

[0040] For the samples, the phase 1 bubble solution was added to the phase 2 liquid solution at a ratio of 1:3, and the peak of chlorine dioxide generation was reached 2 minutes before testing. Figure 4 showing the spectral results indicates that all anthocyanin is decomposed by the generated chlorine dioxide. This can be best confirmed by the disappearance of the peak at 350 nm in the activated sample versus the non-activated sample when maintaining equal anthocyanin starting concentrations.

[0041] Some chlorine dioxide generation tests were conducted to confirm that although some chlorine dioxide is consumed by the oxidation of the dye, the overall chlorine dioxide generation level is still at the expected level. Figure 5 shows the chlorine dioxide generation profiles for multiple samples of the above bubble-liquid system with and without added dye. As shown by the graph in Figure 5, some interference is observed during the initial reaction of the dye with chlorine dioxide, but after about 30 seconds, the curve profiles and peak levels within the experimental error range are substantially the same.

[0042] Microbiological confirmation tests were also performed to confirm that the efficacy is maintained upon introduction of the selective dye.

[0043] In addition, a dye selectivity test was conducted to examine whether the anthocyanin dye reacts or decomposes in the presence of other conventionally used high-level disinfectants and oxidizing agents such as hydrogen peroxide, peracetic acid, and chlorine. For this test, wipes impregnated with 9 ml of 1% AnthoCarrot base were used, and 3 ml of each product (equal to one dose of the first component from pump 2) was obtained. Next, these wipes were manually rolled up for 15 seconds and photographed at the 0, 30, and 60 second time points. These wipes are shown in Figure 6. In Figure 6, the bright contrast areas correspond to the pink-red color characteristic of the AnthoCarroto dye, and the dark contrast areas correspond to the wet areas of the wipes that come into contact with the disinfected surface. The results are summarized and shown in Table 1.

[0044] JPEG0007714021000001.jpg66170

[0045] As can be understood from Table 1, only chlorine (1000 ppm) affected the dye. Other high-level disinfectants and strong oxidizing agents were unable to completely decompose the color of the wipes. In the case of chlorine, most of the dye coloring could be removed, but it could not be completely wiped out, and some spots remained even after 60 seconds. Furthermore, the wipes themselves were affected by chlorine and changed color to off-white instead of their original color, similar to when exposed to chlorine dioxide. Based on this, it can be said that the anthocyanin dye shows high specific selectivity for chlorine dioxide and can be used as one of the criteria for wipe activation.

[0046] In yet another selectivity test, 0.5% anthocyanin (AnthoCarrot) was added to normal oxidizing agents as a liquid, and the resulting mixture was spectroscopically analyzed. As shown in the results in Figure 7, peracetic acid and hydrogen peroxide were unable to completely oxidize the dye, and color development was observed. Chlorine decomposed most of the dye, but precipitates remained.

[0047] Various other dyes were tested to evaluate their suitability for use in the present invention. The main requirements for a suitable dye are whether it is stable in at least one of the two components of the disinfectant system, whether it oxidizes easily in the presence of chlorine dioxide, and whether it lacks stability or does not oxidize or oxidizes in other major oxidizing compounds.

[0048] For the dye samples, stability was tested using the liquid variant and wipe variant of the second component of the system, and chlorine dioxide generated when samples of the liquid and gas bubbles of the first component were combined with the second component. Further tests were also conducted on the following oxidizing agents / disinfectants commonly in use. Hydrogen peroxide (30,000 ppm) Hydrogen peroxide spray - surfactant (commercially available Ecolab Oxifoam) Peracetic acid 10,000 ppm Combined use of peracetic acid / hydrogen peroxide (10,000 ppm) Chlorine 1,000 ppm Triamine / quaternary ammonium disinfectant (Amity Virosol+)

[0049] Tests were conducted on the following types of dyes, and it was confirmed that they were suitable for selective oxidation by chlorine dioxide and showed stability before use. The same results were not obtained when any of the dyes were used with the above disinfectants. Black carrot extract (such as AnthoCarrot L - WS E163), purple carrot powder, haskap berry extract, anthocyanins such as E163 food coloring additive and blackcurrant extract; Anthocyanidins such as bilberry extract and cowpea (blue pea extract); and Betanins such as beetroot powder, E162 beetroot powder and beetroot juice concentrate.

[0050] In the case of several other types of dyes, it was found that their suitability for use was lower than that of anthocyanin dyes, anthocyanidin dyes and betanin dyes. For example, Carmosine (E122) and Allura Red (E129) are easily oxidized by chlorine dioxide, but potentially have the possibility of forming harmful by-products when subjected to extreme heat; In the case of tartrazine (E102, Cl 19140 FD&C Yellow), it has been found to oxidize in the presence of oxidizing disinfectants other than chlorine dioxide; Chromium oxide did not completely oxidize in the presence of chlorine dioxide, but precipitates occurred during the reaction; Ponceau (E124) did not oxidize during chlorine dioxide exposure at levels below 2000 ppm; Indigocarmine potentially has the possibility of forming harmful by-products; Xanthene dyes potentially have the possibility of forming harmful degradation products; and Brilliant Blue FCF (E133, Food Blue 2 Cl 42090) has been found to oxidize in the presence of oxidizing disinfectants other than chlorine dioxide.

[0051] In the case of the disinfection system of the present invention, when using chlorine dioxide-selective dyes, there is also an effect that not only can it be confirmed that chlorine dioxide has been generated, but also that the exact level of chlorine dioxide has been generated. Since the rate at which the selected dye oxidizes is directly proportional to the inclusion rate, by adjusting the inclusion rate (i.e., the amount of dye added), complete decolorization can be ensured once a certain chlorine dioxide level has been reached.

[0052] As is already known, the generation rate of chlorine dioxide is directly proportional to temperature (see, for example, "Kinetics of the Preparation of Chlorine Dioxide by Sodium Chlorite and Hydrochloric Acid at Low Concentration" by Mo et al., Chemical Engineering Transactions (46) 49 - 54 2015). As the temperature increases, the generation rate increases. Since the oxidation rate of the dye is directly proportional to the generation rate, incorporating a selective chlorine dioxide dye indicator can mitigate the influence of temperature on the generation rate during use. Therefore, regardless of the temperature during system use, it can be considered that the target chlorine dioxide level has not been reached until all dye colors become invisible to the naked eye.

[0053] Tests were conducted to show that the exact level of chlorine dioxide can be reliably confirmed by using anthocyanin dyes. When conducting the tests, AnthoCarrot dye and two other comparative control examples were used. The reaction temperature of the solution is shown in Table 2. Spectrophotometric analysis was performed during the oxidation of all dyes to confirm the generation of the intended level of chlorine dioxide. The chlorine dioxide level was analyzed before all dyes were oxidized to determine the quasi - optimal level of chlorine dioxide. As a result of using each dye tested on different chlorine dioxide formulations with different intended final concentrations, it was found that a verification effect was observed for multiple dyes and the product as a whole.

[0054] JPEG0007714021000002.jpg46170

[0055] From these results, it can be seen that for various dyes including anthocyanin dyes that can be suitably used in the present invention, regardless of temperature, the presence of the target level of chlorine dioxide can be effectively confirmed by exhibiting complete oxidation. By adjusting the dye inclusion rate, the concentration of chlorine dioxide at which the dye is completely oxidized can be appropriately selected.

[0056] Also, by using a camera, appropriate software, or other suitable devices, the presence and absence of dye pigments can be accurately determined. Therefore, the generation of active chlorine dioxide can be reliably confirmed.

[0057] Next, referring to FIG. 8 for explanation, FIG. 8 is a schematic diagram of an apparatus 18 for determining whether the wipe 16 contains sufficient chlorine dioxide. The apparatus 18 has a lamp 20 that irradiates at least one surface area of the cloth wipe 16, and in this case, at least one wavelength of light corresponds to the wavelength absorbed by the selective dye. In this embodiment, the Antho Black Carrot extract absorbs light in the range of about 450 nm to about 560 nm, and its peak is at about 530 nm (green). The determination apparatus 18 has a device 22 for measuring the intensity of at least one wavelength of the light, and a comparison device 24 for comparing the value of this intensity with a preset threshold value. The signal device 26 indicates that the wipe contains sufficient chlorine dioxide when the intensity value is equal to or greater than the threshold value (indicating that the dye is not absorbing light). If the intensity value is less than the threshold value, the signal device 26 indicates that the chlorine dioxide content of the wipe 16 is insufficient (the dye is absorbing light). In this embodiment, the signal device has a display 28 that is a visual indicator. Note that other signals such as sound and colored light can also be used, and the signals can be digitally recorded on a PC or other suitable devices additionally or alternatively.

[0058] In the step of obtaining the intensity value, the intensity of at least one wavelength of the light reflected from a plurality of surface areas of the cloth wipe may be measured, and the intensity value may be calculated as the average of each measurement value. To make this step easy to use, the apparatus 18 may further include a component or element for calculating the intensity value as the average of a plurality of intensity measurement values.

[0059] In the case of this device, it can be configured to measure the intensities of multiple wavelengths of light and / or the wavelength range of light. For one or more selected wavelengths, it is preferably corresponding to wavelengths that are strongly absorbed by the dye before activation and not absorbed after activation, and it is also preferable to avoid the interference from chlorine dioxide that shows absorption at approximately 360 nm and approximately 445 nm. In the case of Antho Black Carrot Extract, the selected wavelength may be in the range of approximately 500 nm to approximately 560 nm, preferably approximately 530 nm.

[0060] Instead of spectroscopic analysis, it is also possible to utilize a machine vision system that uses image analysis technology to identify the colors before and after the reaction and determine when sufficient chlorine dioxide is generated.

[0061] The term "fluid" as used herein is a term that encompasses liquids, bubbles, sprays, pastes, aerosols, powders, sols, and gels. It is particularly preferred to provide the first component as a bubble or a spray to facilitate covering the target area of the wipe. Also, the term "chlorine dioxide disinfecting composition" refers to a disinfecting composition whose active ingredient is chlorine dioxide.

[0062] The above example relates to a disinfection system having a bubble activator (which becomes the first component) and a cloth tissue (which becomes the second component), and the second component contains a dye, but this is just an example. Table 3 shows examples of possible supply forms of the first component containing sodium chlorite, and Table 4 shows examples of possible supply forms of the second component containing an acid. JPEG0007714021000003.jpg97167

[0063] JPEG0007714021000004.jpg145165

[0064] Additive components can be added to one or both components to enhance performance or achieve the desired effect or behavior. These additive components include, for example, powder surfactants / liquid surfactants (nonionic surfactants are preferred, but cationic surfactants, amphoteric surfactants, and / or anionic surfactants can also be used), chelating agents that exhibit high affinity for sodium blockade (agents that increase the decomposition rate of sodium chlorite), and foaming agents; dyes; fragrances; odor inhibitors (such as zeolite); secondary oxidizing agents such as sodium percarbonate; absorbent materials (such as superabsorbent polymers, naturally derived clays, and pumice blends); and thickeners.

[0065] Table 5 shows some possible combination examples of these dosage forms. In some applications, when these components are mixed, a thickened disinfection composition is obtained, which may be diluted prior to use. In other applications, when these components are mixed, a ready-to-use disinfection composition is obtained. The mixing ratio of these components can be selected according to the composition and application, and can be 1:3 and 3:1, and can be more than this. In some examples, the mixing ratio is 1:1.

[0066] JPEG0007714021000005.jpg8687

[0067] The treatment mode of treating the first component and the second component as bubbles is described in WO 2006 / 079822 A1. In such a system, the bubbles can be mixed after being taken out from the dispenser, or can be mixed in the dispenser immediately before taking out. On the other hand, in the present invention, since a selective dye is added to the first component and / or the second component, the bubble mixture first exhibits a color change of the dye, and then after sufficient chlorine dioxide is generated in the mixture, this color change changes to the color after oxidation. The mixed bubbles can be added directly to the surface or the object, added to a wipe and treated on the surface, or treated by other suitable methods.

[0068] Modifications and corrections not explicitly stated in this specification can also be implemented without departing from the scope of the invention described in the claims.

Explanation of Symbols

[0069] 2 Pump Dispenser 4 Sealed Container 6 Disinfection System 8 Bag 10 Box 12 Bag 14 Box 16 Cloth Wipe 18 Judgment Device 20 Lamp 22 Device 24 Comparison Device 26 Signal Device 28 Display

Claims

1. (a)a first component having a first reagent in a carrier, and (b)a second component that is admixed with the first component and has a second reagent in a carrier, a disinfectant system in which the first reagent and the second reagent react when the first component and the second component are mixed to produce a chlorine dioxide disinfecting composition, wherein the first component or the second component further has a dye that oxidizes in the presence of chlorine dioxide and exhibits a visible color change when the first component and the second component are mixed, wherein the color change does not occur upon exposure of the component containing the dye (dye-containing component) to a hydrogen peroxide disinfectant and / or a peracetic acid disinfectant, wherein the dye is an anthocyanin dye selected from the group consisting of black carrot extract, purple carrot extract, haskap berry extract and blackcurrant extract, an anthocyanidin dye selected from the group consisting of bilberry extract and blueberry extract, or a betanin dye selected from the group consisting of red beetroot powder and beetroot juice concentrate A disinfectant system characterized by the above.

2. The disinfectant system according to claim 1, wherein the dye changes color from colored to colorless in the presence of chlorine dioxide.

3. The disinfectant system according to claim 1 or 2, wherein the first reagent has a metal chlorite and the second reagent has an acid.

4. The disinfectant system according to any one of claims 1 to 3, wherein the first reagent is housed in a dispenser and can be dispensed as a fluid.

5. The disinfectant system according to any one of claims 1 to 4, wherein the second component is absorbed or impregnated in at least one wipe.

6. The disinfectant system according to any one of claims 1 to 4, wherein the first component and the second component each have a liquid.

7. The disinfectant system according to any one of claims 1 to 4, wherein the first component and the second component each have bubbles.

8. The disinfectant system according to any one of claims 1 to 7, wherein the second component has the dye.

9. The disinfectant system according to any one of claims 1 to 8, wherein the first component or the second component has about 0.1 wt% to about 2 wt% of the dye.

10. The disinfectant system according to any one of claims 1 to 9, wherein substantially all of the dye is oxidized by the generated chlorine dioxide after the first reagent and the second reagent are mixed.

11. The disinfectant system according to any one of claims 1 to 10, wherein the discoloration does not occur upon exposure of the dye-containing component to the quaternary ammonium compound-based disinfecting composition.

12. The disinfectant system according to any one of claims 1 to 11, wherein the discoloration does not occur upon exposure of the dye-containing component to the triamine-based disinfecting composition.

13. A method for confirming that a chlorine dioxide disinfecting composition has been produced using the disinfectant system according to any one of claims 1 to 12, comprising: mixing the first component and the second component; observing the discoloration during mixing of the first component and the second component; and determining that the chlorine dioxide disinfecting composition has been produced when the discoloration has ended and is spatially uniform.

14. (a) A first component having a first reagent in a carrier, and (b) a second component that is miscible with the first component and has a second reagent in a carrier, A disinfectant system in which the first reagent and the second reagent react upon mixing of the first component and the second component to produce a chlorine dioxide disinfecting composition, wherein the first component or the second component further has a dye that oxidizes in the presence of chlorine dioxide and exhibits a visible color change upon mixing of the first component and the second component, wherein the discoloration does not occur upon exposure of the component containing the dye (dye-containing component) to a hydrogen peroxide disinfectant and / or a peracetic acid disinfectant, wherein the dye is an anthocyanin dye, an anthocyanidin dye, or a betanin dye, wherein the first reagent is contained in a dispenser and can be dispensed as a fluid, wherein the second component is absorbed or impregnated in at least one wipe A disinfectant system characterized by the above.

15. (a) A first component having a first reagent in a carrier, and (b) a second component that is miscible with the first component and has a second reagent in a carrier, A disinfectant system in which the first reagent and the second reagent react upon mixing of the first component and the second component to produce a chlorine dioxide disinfecting composition, wherein the first component or the second component further has a dye that oxidizes in the presence of chlorine dioxide and exhibits a visible color change upon mixing of the first component and the second component, wherein the discoloration does not occur upon exposure of the component containing the dye (dye-containing component) to a hydrogen peroxide disinfectant and / or a peracetic acid disinfectant, wherein the dye is an anthocyanin dye, an anthocyanidin dye, or a betanin dye, The first component and the second component each have bubbles. A disinfectant system characterized by this. **Claim 16**: (a) A first component having a first reagent in a carrier, and (b) A second component that is miscible with the first component and has a second reagent in a carrier, A disinfectant system in which the first reagent and the second reagent react when the first component and the second component are mixed to produce a chlorine dioxide disinfection composition, The first component or the second component further has a dye that oxidizes in the presence of chlorine dioxide and exhibits a visible color change when the first component and the second component are mixed, The color change does not occur when the component containing the dye (dye-containing component) is exposed to a hydrogen peroxide disinfectant and / or a peracetic acid disinfectant, The dye is an anthocyanin dye, an anthocyanidin dye, or a betanin dye, After the first reagent and the second reagent are mixed, almost all of the dye is oxidized by the generated chlorine dioxide A disinfectant system characterized by this.

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