Compositions for small molecule therapeutic compounds

Abstract

Compositions and formulations for small molecule therapeutic agents, and drug delivery devices containing the compositions and formulations for the controlled, sustained delivery of small molecule therapeutic agents, are provided. [Solution] A composition is provided, comprising an aqueous suspension containing a small molecule therapeutic agent and an organic acid. The small molecule therapeutic agent is a base and has an aqueous solubility of less than about 1.0 g / L at room temperature. The organic acid has an aqueous solubility of 0.1 to 10 at room temperature, a molar mass of less than 500 grams per mole, and / or maintains a pH of the suspension in a use environment of 3.0 to 6.5. The organic acid improves the solubility of the small molecule therapeutic agent, and when present in a stoichiometric excess, the organic acid causes release of the small molecule therapeutic agent into a buffered environment for an extended period of time, e.g., six months to one year. Devices and methods of treatment containing the composition are also provided.

Description

[Technical Field]

[0001] This application claims the benefit of U.S. Provisional Application No. 62 / 399,083, filed September 23, 2016, which is incorporated herein by reference.

[0002] The subject matter described herein relates to compositions and formulations for small molecule therapeutic agents and drug delivery devices including compositions and formulations for the controlled, sustained delivery of small molecule therapeutic agents. [Background technology]

[0003] An important class of small molecule drugs exhibits poor aqueous solubility at neutral pH. While this property can be advantageous for oral absorption and tissue penetration, it complicates the development of injectable or implantable sustained-delivery systems that rely on passive diffusion as the primary drug release mechanism; for example, low solubility prevents the generation of a sufficient concentration gradient to generate adequate efflux from a reservoir containing an aqueous suspension of the drug. Many insoluble drugs are weak organic bases (i.e., molecules containing at least one functional group, such as a primary, secondary, or tertiary amine, aniline, or amidine), and their aqueous solubility is improved by protonation (i.e., when converted to a salt). However, such salts are unstable and susceptible to hydrolysis at pHs near or above the pKa of the protonated drug. This process complicates the development of implant- or depot-based diffusion-mediated drug delivery systems, as drug efflux from the formulation must be coupled with the influx of buffer species from physiological fluids. There is a need for compositions and devices that address these and other complex factors associated with the sustained and controlled delivery of small molecule therapeutics that are weak organic bases. Summary of the Invention

[0004] The aspects and embodiments thereof described and illustrated below are intended to be exemplary and illustrative, not limiting in scope.

[0005] In some embodiments, a composition is provided comprising an aqueous suspension comprising a small molecule therapeutic agent (i) having an aqueous solubility of less than 1 g / L at room temperature and (ii) that is a weak base (i.e., has a conjugate acid with a pKa of 6-9), combined with a stoichiometric excess of an organic acid (i) having an aqueous solubility of less than about 20 g / L at room temperature and (ii) that maintains the pH of the suspension in its use environment between pH 3 and 6.5 for a period of at least about 30 days.

[0006] In another embodiment, a composition is provided comprising an aqueous suspension comprising a small molecule therapeutic agent (i) having an aqueous solubility of less than 1 g / L at room temperature and (ii) that is a weak base (i.e., has a conjugate acid with a pKa of 6-9), combined with a stoichiometric excess of an organic acid that (i) has an aqueous solubility of 0.1-10 g / L at room temperature; (ii) has a molecular weight of less than 500 grams per mole; and (iii) maintains the pH of the suspension in its use environment between pH 3 and 6.5 for a period of at least about 30 days.

[0007] In another embodiment, a composition is provided comprising an aqueous suspension comprising a small molecule therapeutic agent (i) having an aqueous solubility of less than 1 g / L at room temperature and (ii) rendered more soluble upon protonation, combined with a stoichiometric excess of an organic acid that (i) has an aqueous solubility of less than 20 g / L at room temperature and (ii) maintains the pH of the suspension in its use environment at or below the pKa of the protonated drug for a period of at least about 30 days.

[0008] In another embodiment, a composition is provided comprising an aqueous suspension comprising a small molecule therapeutic agent (i) having an aqueous solubility of less than 1 g / L at room temperature and (ii) rendered more soluble upon protonation, in combination with a stoichiometric excess of an organic acid that (i) has an aqueous solubility of 0.1 to 10 g / L at room temperature; (ii) has a molecular weight of less than 500 grams per mole; and (iii) maintains the pH of the suspension in its use environment at or below the pKa of the protonated drug for a period of at least about 30 days.

[0009] In some embodiments, the aqueous suspension is a heterogeneous mixture comprising a small molecule therapeutic agent and an organic acid, wherein the organic acid is sufficiently soluble to maintain the pH of the heterogeneous solution in its use environment at or below physiological pH (about 7.4) for a period of time. In some embodiments, the use environment is in vivo. In another embodiment, the use environment is in vitro with the release medium maintained at 37°C.

[0010] In some embodiments, the organic acid is present at the end of the period in an amount that is about equal to or greater than its saturation concentration.

[0011] In another embodiment, the organic acid is present in a stoichiometric (molar) amount ranging from about 105% to 1000% relative to the therapeutic agent, but may be as much as 10,000% greater. In other embodiments, the organic acid, on a molar basis, is 110%, 125%, 150%, 175%, 200%, 250%, 300%, 350%, 400%, 450%, or 500% greater than the amount of therapeutic agent in the composition.

[0012] In another embodiment, the organic acid is crystalline and has a melting point above about 37°C.

[0013] In yet another embodiment, the small molecule therapeutic agent is an antipsychotic drug.

[0014] In other embodiments, the antipsychotic drug is risperidone, olanzapine, paliperidone, aripiprazole, brexpiprazole, or asenapine.

[0015] In some embodiments, the aqueous suspension comprises or is prepared using an organic acid suspended in a water-based solution, such as an aqueous buffer solution.

[0016] In another embodiment, the aqueous suspension comprises or is prepared using a preformed salt of the therapeutic agent with an organic acid, where the acid is present in a stoichiometric (molar) excess.

[0017] In another embodiment, the therapeutic agent and a stoichiometric (molar) excess of an organic acid are thoroughly mixed by dissolution in a polar organic solvent such as methanol, ethanol, 1-propanol, 2-propanol, tert-butanol, acetone, 2-butanone, or ethyl acetate, and the intermediate solution is concentrated to dryness.

[0018] In some embodiments, the organic acid is an aromatic carboxylic acid. In some embodiments, the typical organic acid is an organic acid having a carboxylic acid group attached to an unsubstituted benzene ring or a pyridine ring. In some embodiments, the carboxylic acid is selected from the group consisting of benzoic acid, picolinic acid, nicotinic acid, and isonicotinic acid.

[0019] In another embodiment, the carboxylic acid is a carboxylic acid having a benzene ring and one electron donating group. In another embodiment, the carboxylic acid has antioxidant properties.

[0020] In yet another embodiment, the carboxylic acid is selected from the group consisting of o-anisic acid, m-anisic acid, p-anisic acid, p-aminobenzoic acid (PABA), o-aminobenzoic acid (anthranilic acid), o-toluic acid, m-toluic acid, p-toluic acid, and salicylic acid.

[0021] In another embodiment, the carboxylic acid is a carboxylic acid having a benzene ring and two electron donating groups.In another embodiment, the carboxylic acid has antioxidant properties.In some embodiments, and by way of example, the carboxylic acid is vanillic acid.

[0022] In yet another embodiment, the carboxylic acid is a carboxylic acid having at least two carboxylic acid groups attached to a benzene ring. In one embodiment, and by way of example, the carboxylic acid is phthalic acid.

[0023] In yet another embodiment, the carboxylic acid is a carboxylic acid having a carboxylic acid group attached to a naphthalene ring or a quinoline ring. In some embodiments, and by way of example, the carboxylic acid is selected from the group consisting of 1-naphthoic acid, 2-naphthoic acid, quinaldic acid, 3-quinolinecarboxylic acid, 4-quinolinecarboxylic acid, 5-quinolinecarboxylic acid, 6-quinolinecarboxylic acid, 7-quinolinecarboxylic acid, and 8-quinolinecarboxylic acid.

[0024] In another embodiment, the carboxylic acid comprises an aromatic ring having an electron donating group selected from the group consisting of hydroxy, methoxy, amino, alkylamino, dialkylamino, and alkyl. In certain embodiments, and by way of example, the carboxylic acid is selected from the group consisting of 6-hydroxy-2-naphthoic acid, 6-hydroxy-3-naphthoic acid, 8-hydroxy-2-quinolinecarboxylic acid, and 8-hydroxy-7-quinolinecarboxylic acid.

[0025] In yet another embodiment, the carboxylic acid is a carboxylic acid having one or two carboxylic acid groups directly attached to the biphenyl ring system. In some embodiments, and by way of example, the carboxylic acid is selected from the group consisting of 2-phenylbenzoic acid, 3-phenylbenzoic acid, 4-phenylbenzoic acid, and diphenic acid.

[0026] In yet another embodiment, the carboxylic acid is a carboxylic acid having one additional electron-donating substituent in addition to the hydroxyl group of the carboxylic acid moiety. In some embodiments, and by way of example, the carboxylic acid is selected from the group consisting of 4'-hydroxy-4-biphenylcarboxylic acid, 4'-hydroxy-2-biphenylcarboxylic acid, 4'-methyl-4-biphenylcarboxylic acid, 4'-methyl-2-biphenylcarboxylic acid, 4'-methoxy-4-biphenylcarboxylic acid, and 4'-methoxy-2-biphenylcarboxylic acid.

[0027] In yet another embodiment, the carboxylic acid is a carboxylic acid having a carboxylic acid functionality separated from a benzene ring, a pyridine ring, a naphthalene ring, or a quinoline ring by a chain of 1 to 4 saturated carbon atoms. In certain embodiments, and by way of example, the carboxylic acid is phenylacetic acid or 3-phenylpropionic acid.

[0028] In another embodiment, the carboxylic acid is an aliphatic dicarboxylic acid having a 4-8 carbon chain separating the carboxylic acid groups. In some embodiments, and by way of example, the carboxylic acid is selected from the group consisting of adipic acid ((CH2)4(COOH)2), pimelic acid (HO2C(CH2)5CO2H), suberic acid (HO2C(CH2)6CO2H), azelaic acid (HO2C(CH2)7CO2H), and sebacic acid (HO2C(CH2)8CO2H).

[0029] In another embodiment, the carboxylic acid is an unsaturated or polyunsaturated dicarboxylic acid containing 4 to 10 carbons. In some embodiments, and by way of example, the carboxylic acid is selected from the group consisting of fumaric acid, trans,trans-muconic acid, cis,trans-muconic acid, and cis,cis-muconic acid.

[0030] In other embodiments, the carboxylic acid is cis-cinnamic acid or trans-cinnamic acid. In yet other embodiments, the carboxylic acid is trans-cinnamic acid having one or two electron-donating groups selected from hydroxy, methoxy, amino, alkylamino, dialkylamino, or alkyl groups. In yet other embodiments, the trans-cinnamic acid is selected from the group consisting of o-coumaric acid, m-coumaric acid, p-coumaric acid, o-methylcinnamic acid, m-methylcinnamic acid, p-methylcinnamic acid, o-methoxycinnamic acid, m-methoxycinnamic acid, p-methoxycinnamic acid, and ferulic acid.

[0031] In certain embodiments, the organic acid is a phenol or naphthol substituted with about 2-5 electron-withdrawing groups selected from F, Cl, Br, I, CN, and NO. In certain embodiments, and by way of example, the organic acid is pentafluorophenol or 2,4-dinitrophenol.

[0032] In another embodiment, the organic acid is a 1,3-dicarbonyl compound containing an acidic (pKa<8) C-H bond. In certain embodiments, and by way of example, the organic acid is 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid), cyanuric acid, or barbituric acid.

[0033] In yet another embodiment, the organic acid is an imide. In some embodiments, and by way of example, the imide is phthalimide or a substituted phthalimide. In another embodiment, the substituted phthalimide has at least one electron-withdrawing substituent.

[0034] In yet another embodiment, the organic acid is a hydroxamic acid. In some embodiments, and by way of example, the hydroxamic acid is an aromatic hydroxamic acid containing a hydroxamic functional group directly bonded to the aromatic ring. In some embodiments, the aromatic ring is selected from the group consisting of a benzene ring, a pyridine ring, a naphthalene ring, a quinolone ring, and a biphenyl ring. In yet another embodiment, the hydroxamic acid is a benzhydroxamic acid. In yet another embodiment, the hydroxamic acid has 1 to 4 sp 3 It is a hydroxamic acid that contains a hydroxamic functional group separated from an aromatic ring by a chain of hybridized carbon atoms.

[0035] In yet another embodiment, the aromatic ring is selected from the group consisting of a benzene ring, a pyridine ring, a naphthalene ring, a quinoline ring, and a biphenyl ring.

[0036] In yet another embodiment, the hydroxamic acid is a dihydroxamic acid, which contains two or more hydroxamic acid functional groups directly attached to a benzene, pyridine, naphthalene, quinoline, or biphenyl ring system.

[0037] In other embodiments, the hydroxamic acid comprises an aromatic ring bearing an electron-donating substituent selected from hydroxy, methoxy, amino, alkylamino, dialkylamino, and alkyl groups.

[0038] In other embodiments, the hydroxamic acid is an aliphatic dihydroxamic acid containing from 6 to 10 carbon atoms.

[0039] In some embodiments, the hydroxamic acid is suberohydroxamic acid.

[0040] In other embodiments, the hydroxamic acid is an unsaturated dihydroxamic acid containing from 6 to 10 carbon atoms.

[0041] In another embodiment, the aromatic carboxylic acid is selected from the group consisting of 3-phenylpropionic acid, cinnamic acid, hydroxy derivatives of cinnamic acid, methoxy derivatives of cinnamic acid, nicotinic acid, benzoic acid, amino derivatives of benzoic acid, methoxy derivatives of benzoic acid, and phthalic acid.

[0042] In yet another embodiment, the hydroxy derivative of silicic acid is m-coumaric acid or p-coumaric acid.

[0043] In still other embodiments, the p-coumaric acid is trans-p-coumaric acid.

[0044] In another embodiment, the methoxy derivative of silicic acid is p-methoxycinnamic acid or m-methoxycinnamic acid.

[0045] In still other embodiments, the amino derivative of benzoic acid is o-amino-benzoic acid (anthranilic acid) or 4-aminobenzoic acid (para-aminobenzoic acid; PABA).

[0046] In another embodiment, the methoxy derivative of benzoic acid is 4-methoxybenzoic acid (p-anisic acid), o-anisic acid or m-anisic acid.

[0047] In one embodiment, the composition is in a dry form. In another embodiment, the composition is in a dry form and is hydrated in situ when in its use environment.

[0048] In another aspect, there is provided a device comprising the composition described herein, the device being designed for subcutaneous implantation in a mammal.

[0049] In another embodiment, an implantable device is provided that includes: (i) a reservoir containing a formulation of a small molecule therapeutic agent in an amount sufficient to provide substantially zero-order release of the small molecule therapeutic agent at a rate that provides a therapeutic effect over a delivery period of at least about 30 days; and (ii) an organic acid that (a) maintains the pH of the formulation when hydrated in its use environment of pH 3.0 to 6.5 during the delivery period; (b) is present in stoichiometric (molar) excess relative to the therapeutic agent; and (c) is present when hydrated in an amount that is approximately equal to or exceeds its saturation concentration in the formulation at the end of the delivery period.

[0050] In another embodiment, an implantable device is provided that includes: (i) a reservoir containing a formulation of a small molecule therapeutic agent in an amount to provide substantially zero-order release of the small molecule therapeutic agent at a rate that provides a therapeutic effect over a delivery period of at least about 30 days; and (ii) an organic acid that (a) maintains the pH of the formulation when hydrated at a pKa equal to or lower than that of the protonated drug over the delivery period; (b) is present in a stoichiometric (molar) excess amount relative to the therapeutic agent, and (c) is present when hydrated in an amount that is about equal to or greater than its saturation concentration in the formulation at the end of the delivery period.

[0051] In some embodiments, the formulation is in a dry form. In various embodiments, and by way of example, the formulation is a powder, tablet, or film; or a mixture of two or more powders, tablets, or films.

[0052] In another embodiment, the formulation hydrates in the presence of an aqueous solution to form an aqueous suspension. In some embodiments, the aqueous solution is an in vivo fluid.

[0053] In another embodiment, the small molecule therapeutic agent is released from the device at a rate that provides a therapeutic effect over a period of time.

[0054] In yet another embodiment, the organic acid has a water solubility of less than about 20 g / L at room temperature. In yet another embodiment, the organic acid has a water solubility of 0.1 to 10 g / L at room temperature and a molar mass of less than 500 grams per mole.

[0055] In another embodiment, the organic acid has an aqueous solubility at room temperature of less than about 20 g / L and a pKa of 3 to 6. In another embodiment, the organic acid has an aqueous solubility at room temperature of 0.1 to 10 g / L, a molar mass of less than 500 grams per mole, and a pKa of 3 to 6.

[0056] In another embodiment, two or more organic acids, each having a water solubility of 0.1 to 10 g / L at room temperature, a molar mass of less than 500 grams per mole, and a pKa of 3 to 6, are used in combination.

[0057] In yet another embodiment, the organic acid has a melting point greater than about 37°C.

[0058] In another aspect, methods are provided for sustained, controlled delivery of small molecule therapeutic agents. The methods include providing a composition or device described herein. In some embodiments, the methods further include administering the device, e.g., by subcutaneous implantation.

[0059] In another aspect, methods are provided for sustained, controlled delivery of antipsychotic medications, comprising providing a composition or device described herein. In some embodiments, the methods further comprise administering the device, e.g., by subcutaneous implantation.

[0060] In another aspect, a method for maintenance therapy for treating schizophrenia or bipolar disorder is provided, comprising providing a composition or device described herein. In some embodiments, the method further comprises administering the device, for example, by subcutaneous implantation.

[0061] In addition to the exemplary aspects and embodiments described above, further aspects and embodiments will become apparent by reference to the drawings and by examination of the following descriptions.

[0062] Further embodiments of the methods, devices, compositions, and the like of the present invention will be apparent from the following description, drawings, examples, and claims. As can be understood from the foregoing and following description, each and every feature described herein, and each and every combination of two or more such features, is included within the scope of the present invention, provided that the features included in such combinations are not mutually exclusive. Furthermore, any feature or combination of features may be specifically excluded from any embodiment of the present invention. Further aspects and advantages of the present invention will be described, particularly when considered in conjunction with the accompanying examples and drawings. [Brief explanation of the drawings]

[0063] [Figure 1A-B] 1A and 1B are illustrations of a drug delivery device in assembled (FIG. 1A) and unassembled (FIG. 1B) configurations.

[0064] [Figure 1C-F]

[0023] Figure 1C shows a cross-sectional view (Figure 1C) and an exploded view (Figure 1D) of the assembled configuration, and shows portions of a first exemplary drug delivery device showing the end cap assembly in an isometric view when assembled (Figure 1E). Figure 1F shows an isometric view of the cap assembly only. The numbered components of the subassembly are 1 = cap, 2 = porous membrane, 3 = seal, 4 = retention ring, and 5 = drug device reservoir.

[0065] [Figure 1G-K]Portions of a second exemplary drug delivery device are shown in cross section and isometric views (FIG. 1H) in the assembled configuration (FIG. 1G), and the end cap assembly (FIG. 1E) in an isometric view (FIG. 1I) when assembled. Figures 1J-1K show isometric views of the cap assembly only. The numbered components of the subassembly are 1 = cap, 2 = porous membrane, 3 = seal, 4 = drug delivery device reservoir, and 5 = retention ring.

[0066] [Figure 2] Cumulative release of risperidone in milligrams (mg) as a function of time (days) from drug delivery devices containing heterogeneous aqueous formulations consisting of risperidone and 4-aminobenzoic acid (PABA) at risperidone / PABA molar ratios of 1:1 (diamonds); 1:1.5 (squares); 1:2 (filled circles); and 1:2 with membrane surface area reduced by 50% (open circles).

[0067] [Figure 3A] Figure 1 shows the cumulative release of olanzapine in milligrams (mg) as a function of time (days) from a drug delivery device containing in the device reservoir a heterogeneous aqueous formulation consisting of olanzapine and 4-aminobenzoic acid (PABA, squares) or p-toluic acid (diamonds) at an olanzapine / organic acid molar ratio of 1:1.5, or no acid as a control (circles).

[0068] [Figure 3B] Cumulative release of olanzapine in milligrams (mg) as a function of time (days) from drug delivery devices containing heterogeneous aqueous formulations in the device reservoir consisting of olanzapine and 4-aminobenzoic acid (PABA, *) or p-toluic acid (triangles) at a 2:1 olanzapine / organic acid molar ratio, or no acid (squares) as a control.

[0069] [Figure 4]Plasma concentrations of risperidone in ng / mL are shown as a function of time (days) from subcutaneously implantable drug delivery devices containing aqueous formulations of risperidone and 4-aminobenzoic acid (PABA, circles) or sebacic acid (diamonds) in the device reservoir.

[0070] [Figure 5] Graph showing cumulative in vitro release (expressed as percent of total risperidone released into the receiving medium) for various risperidone salts (PABA, squares; terephthalate, diamonds; sebacate, open diamonds; vanillate, triangles; hippurate, crosses; hydroxyphenylpropionate, open circles; urate, closed circles).

[0071] [Figure 6] Graph of the percent of risperidone released at 15 days in the study of Example 5 (FIG. 5) as a function of the aqueous solubility (mg / mL) of the organic acids terephthalic acid, uric acid, sebacic acid, vanillic acid, hydroxyphenylpropionic acid, hippuric acid, and PABA used in the composition.

[0072] [Figure 7] FIG. 5 is a graph of the percent of risperidone released at 15 days in the test of Example 5 (FIG. 5) as a function of pH (pH at saturation concentration in aqueous solution) for the organic acids used in the compositions: terephthalic acid, uric acid, sebacic acid, vanillic acid, hydroxyphenylpropionic acid, hippuric acid, and PABA.

[0073] Detailed Description I. definition Various aspects are set forth in more detail below. However, such aspects may be embodied in many different forms and should not be construed as limiting the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey its scope to those skilled in the art.

[0074] When a range of numerical values ​​is provided, it is intended that each value between the upper and lower limits of that range, and any other stated or intervening value within that range, is encompassed within the disclosed scope. For example, if a range of 1 mg to 8 mg is stated, then 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, and 7 mg, as well as ranges of values ​​greater than or equal to 1 mg and ranges less than or equal to 8 mg, are also specifically disclosed.

[0075] The singular forms "a," "an," and "the" include plural referents unless the context clearly indicates otherwise. Thus, for example, reference to a "polymer" includes a single polymer and two or more of the same or different polymers, reference to an "excipient" includes a single excipient and two or more of the same or different excipients, etc.

[0076] The word "about," when immediately preceding a value, means a range of plus or minus 10% of that value. For example, unless clearly indicated otherwise by context or contradictory to such an understanding, "about 50" means 45 to 55, "about 25,000" means 22,500 to 27,500, etc. For example, in a list of values ​​such as "about 49, about 50, about 55," "about 50" means a range spanning less than half the interval between the preceding and following values, for example, a range from greater than 49.5 to less than 52.5. Furthermore, the phrases "less than about (value)" or "greater than about (value)" should be understood in light of the definition of the term "about" provided herein.

[0077] The compositions of the present invention may comprise, consist essentially of, or consist of the disclosed components.

[0078] Unless otherwise specified, all percentages, parts and ratios are based on the total weight of the composition and all measurements made are made at about 25°C.

[0079] The phrase "pharmaceutically acceptable" is used herein to refer to compounds, salts, compositions, dosage forms, etc. that are—within the scope of sound medical judgment—suitable for use in contact with the tissues of humans and / or other mammals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit / risk ratio. In some embodiments, "pharmaceutically acceptable" means approved by a federal or state regulatory agency, or listed in the United States Pharmacopoeia or other generally recognized pharmacopoeias, for use in mammals (e.g., animals), and more specifically, humans.

[0080] As used herein, the term "treating" refers to a method of administering a small molecule that reduces the frequency of or delays the onset of symptoms of a medical condition (e.g., schizophrenia, bipolar disorder) in a subject compared to a subject not receiving the compound or composition. This can include reversing, reducing, or halting the symptoms, clinical signs, and pathology underlying the symptoms in a manner that improves or stabilizes the subject's condition (e.g., controlling schizophrenic symptoms).

[0081] A less than full scope of the invention may be claimed for any reason by including, and reserving the right to conditionally exclude or exclude, any individual member of any such group that may be claimed by range or in any similar manner, any sub-range or combination of sub-ranges within the group. Furthermore, a less than full scope of the invention may be claimed by conditionally excluding or excluding any individual substituent, analog, compound, ligand, structure, or group thereof, or any member of a claimed group.

[0082] Throughout this invention, various patents, patent applications, and publications are referenced. The disclosures of these patents, patent applications, and publications in their entireties are incorporated by reference into this disclosure to more fully describe the general state of the art as known to those skilled in the art at the date of this disclosure. In the event of any conflict between the cited patents, patent applications, and publications and this disclosure, the present disclosure will control.

[0083] For convenience, certain terms used in the specification, examples, and claims are collected here. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0084] II. Formulations for improving the solubility of small molecule therapeutic agents In certain embodiments, a composition or formulation is provided in which the small molecule therapeutic agent is solubilized using an organic acid in which it is partially soluble, thereby improving delivery of the therapeutic agent from a device or drug delivery platform for extended periods of time. In certain embodiments, the composition is an aqueous suspension or slurry. In other embodiments, the composition is a heterogeneous or non-uniform mixture or solution. In some embodiments, the solution or mixture can be an aqueous mixture or an aqueous heterogeneous mixture. In other embodiments, the composition is in a dried form (e.g., lyophilized, spray-dried, desiccated, etc.). In various of these embodiments, the composition comprises a small molecule therapeutic agent capable of functioning as a Bronsted base or Lewis base and an organic acid having one or more of the following: (i) an aqueous solubility of less than about 20 g / L or about 0.1-10 g / L at room temperature (e.g., about 25°C); (ii) a molar mass of less than 500 grams per mole; (iii) being present in a stoichiometric (molar) excess amount relative to the therapeutic agent; and (iv) maintaining a pH of the suspension (or solution) in a use environment that is about equal to or less than the pKa of the protonated therapeutic agent for a period of at least about 30 days. The composition can further comprise an aqueous liquid, such as water, a buffer, or an aqueous solvent mixture. In embodiments where the composition is in a dry form, the aqueous liquid hydrates the composition in situ in its use environment.

[0085] As described above, the formulations described herein provide solubility of the small molecule therapeutic agent to enable delivery over a sustained period. In certain embodiments, a sustained period is intended to be at least about 2 weeks to about 6 months. In other embodiments, a sustained period is intended to be at least about 2 weeks, or at least about 3 weeks, or at least about 4 weeks to about 6 months, or about 4 months, or about 3 months. In other embodiments, a sustained period is intended to be at least about 15 days, or at least about 21 days, or at least about 30 days, or at least about 45 days, or at least about 60 days. In other embodiments, a sustained period is intended to be at least about 6 months, or 9 months, or 12 months.

[0086] As mentioned above, the formulations described herein improve the solubility of small molecule therapeutic agents in part by maintaining a specific pH of the formulation in its use environment for a certain period of time.In some embodiments, the use environment is in vivo.For example, the formulation can be part of a drug delivery device that is implanted in vivo, and some examples of such devices are provided below.In another embodiment, the use environment is in vitro in a release medium that is maintained at about 37°C.

[0087] The components of the composition, namely the small molecule therapeutic agent and the organic acid, are described below.

[0088] A. Small molecule therapeutics In some embodiments, the composition comprises a small molecule therapeutic agent that has an aqueous solubility of less than 1.0 g / L at room temperature and (ii) is an organic base. In some embodiments, the term "small molecule" refers to a biologically active molecule having a molecular weight of 2,000 daltons or less, and is generally used in the context of small molecule drugs (therapeutics) to distinguish them from protein, polypeptide, or peptide therapeutics. In other embodiments, the small molecule has a molecular weight of 1,000 daltons or less or 500 daltons or less. In other embodiments, the molecular weight of the small molecule is 10-2,000 daltons, 10-1,000 daltons, 10-500 daltons, 50-2,000 daltons, 50-1,000 daltons, 50-500 daltons, 100-2,000 daltons, 100-1,000 daltons, or 100-500 daltons.

[0089] Contemplated small molecule therapeutic agents include, but are not limited to, agents that are weak organic bases (i.e., have a conjugate acid with a pKa of 6-9 or 5-9) and are potent such that a 30-60 day dose can be contained in a delivery device implanted in a human.

[0090] For example, therapeutic agents containing primary, secondary, or tertiary amine, aniline or aniline derivative, or amidine functional groups are contemplated as small molecule therapeutic agents that are organic bases. It is understood that therapeutic agents having structures containing one or more of these functional groups are contemplated. Examples of aniline derivatives include analogs of aniline in which the phenyl group is replaced with, for example, a methyl group (toluididine), a halogen atom such as chlorine (2-chloroaniline, 3-chloroaniline, 4-chloroaniline), an amino group (4-aminobenzoic acid or 2-aminobenzoic acid or 3-aminobenzoic acid), a nitro group (e.g., 2-, 3-, or 4-nitroaniline), and many others.

[0091] In some embodiments, the small molecule therapeutic agent is an antipsychotic drug, including an atypical antipsychotic. In other embodiments, the small molecule therapeutic agent has activity in treating diseases of the central nervous system. Exemplary agents include, but are not limited to, risperidone, olanzapine, asenapine, aripiprazole, or brexpiprazole.

[0092] In some embodiments, the small molecule drug is i) poorly water soluble at physiological pH (about 7.4) and ii) functions as a Bronsted base or Lewis base. As described below, a suspension or slurry is prepared in the presence of an aqueous liquid and a stoichiometric excess of an organic acid that i) has an aqueous solubility of between 0.1 and 10 g / L or less than 20 g / L at 25° C. and ii) will at least partially dissolve in the presence of the drug and a physiological buffer, at a pH (in the aqueous fraction) about equal to or less than the pKa of the protonated drug.

[0093] B.Organic acid In addition to the small molecule therapeutic agent, the composition includes an organic acid or combination of organic acids. The organic acid has one or more of the following characteristics: (i) an aqueous solubility of between 0.1 and 10 g / L and less than about 20 g / L at room temperature; (ii) a molar mass of less than 500 grams per mole; (iii) a stoichiometric excess relative to the therapeutic agent; and (iv) maintains the pH of the suspension or solution in its use environment at or below the pKa of the protonated small molecule therapeutic agent for a period of at least about 30 days. As described above, the composition improves the solubility of the small molecule therapeutic agent, enabling the composition to be used in drug delivery platforms that provide extended sustained release. The excess acid (on a stoichiometric basis relative to the therapeutic agent) interferes with physiological buffering species that would otherwise cause hydrolysis of the pharmacologically active salt. Examples of organic acids for use in the composition are described below.

[0094] In a first embodiment, the organic acid is a carboxylic acid. Examples include aromatic carboxylic acids in which the carboxylic acid group is directly bonded to the aromatic ring. For example, the aromatic carboxylic acid may have one carboxylic acid group bonded to an unsubstituted benzene or pyridine ring. Examples include benzoic acid, picolinic acid, nicotinic acid, or isonicotinic acid. In another example, the aromatic carboxylic acid is a carboxylic acid having a benzene ring and one electron-donating group with antioxidant properties. Specific examples include o-anisic acid, m-anisic acid, p-anisic acid, p-aminobenzoic acid (PABA), o-aminobenzoic acid (anthranilic acid), o-toluic acid, m-toluic acid, p-toluic acid, and salicylic acid.

[0095] In yet another example, the aromatic carboxylic acid may have a single benzene ring and two electron-donating groups with antioxidant properties. A specific example is vanillic acid. In yet another example, the aromatic carboxylic acid is a carboxylic acid having two or more carboxylic acid groups attached to the benzene ring. A specific example is phthalic acid.

[0096] In another example, the aromatic carboxylic acid is a carboxylic acid containing one carboxylic acid group attached to a naphthalene or quinoline ring. Examples include 1-naphthoic acid, 2-naphthoic acid, quinaldic acid, 3-quinolinecarboxylic acid, 4-quinolinecarboxylic acid, 5-quinolinecarboxylic acid, 6-quinolinecarboxylic acid, 7-quinolinecarboxylic acid, and 8-quinolinecarboxylic acid. A further class of acids of this type, which have one carboxylic acid group attached to a naphthalene or quinoline ring, includes acids containing additional electron-donating groups, such as hydroxy, methoxy, amino, alkylamino, dialkylamino, or alkyl groups. Examples of acids of this class include 6-hydroxy-2-naphthoic acid, 6-hydroxy-3-naphthoic acid, 8-hydroxy-2-quinolinecarboxylic acid, 8-hydroxy-7-quinolinecarboxylic acid, and their respective isomers.

[0097] In another exemplary embodiment, the carboxylic acid is a carboxylic acid containing one carboxylic acid group attached to the naphthalene or quinoline ring and an electron-donating substituent in addition to the hydroxyl group on the carboxylic acid moiety. Examples include 4'-hydroxy-4-biphenylcarboxylic acid, 4'-hydroxy-2-biphenylcarboxylic acid, 4'-methyl-4-biphenylcarboxylic acid, 4'-methyl-2-biphenylcarboxylic acid, 4'-methoxy-4-biphenylcarboxylic acid, and 4'-methoxy-2-biphenylcarboxylic acid.

[0098] In another exemplary embodiment, the acid is a dicarboxylic or tricarboxylic acid having two or three carboxylic acid groups attached to the naphthalene or quinoline ring. Examples include 1,4-naphthalenedicarboxylic acid and 2,6-naphthalenedicarboxylic acid.

[0099] In another exemplary embodiment, the carboxylic acid is a carboxylic acid having one or two carboxylic acid groups directly attached to the biphenyl ring system. Examples include 2-phenylbenzoic acid, 3-phenylbenzoic acid, 4-phenylbenzoic acid, and diphenic acid.

[0100] In another exemplary embodiment, the carboxylic acid is a carboxylic acid having the carboxylic acid functionality separated from the benzene, pyridine, naphthalene, or quinoline ring by a saturated chain of 1 to 4 carbon atoms. Exemplary acids in this embodiment include phenylacetic acid and 3-phenylpropionic acid.

[0101] In another exemplary embodiment, the carboxylic acid is an aliphatic dicarboxylic acid having 6 to 10 carbon atoms, such as adipic acid ((CH2)4(COOH)2), pimelic acid (HO2C(CH2)5CO2H), suberic acid (HO2C(CH2)6CO2H), azelaic acid (HO2C(CH2)7CO2H), and sebacic acid (HO2C(CH2)8CO2H).

[0102] In another exemplary embodiment, the carboxylic acid is an unsaturated or polyunsaturated dicarboxylic acid containing 4 to 10 carbons. Exemplary acids in this embodiment include fumaric acid, trans,trans-muconic acid, cis,trans-muconic acid, and cis,cis-muconic acid.

[0103] In another exemplary embodiment, the carboxylic acid is cis-cinnamic acid or trans-cinnamic acid. In some embodiments, the trans-cinnamic acid contains one or two electron-donating groups selected from a hydroxy group, a methoxy group, an amino group, an alkylamino group, a dialkylamino group, or an alkyl group. Examples include o-coumaric acid, m-coumaric acid, p-coumaric acid, o-methylcinnamic acid, m-methylcinnamic acid, p-methylcinnamic acid, o-methoxycinnamic acid, m-methoxycinnamic acid, and p-methoxycinnamic acid, and ferulic acid.

[0104] In another embodiment, the organic acid is a phenol or naphthol substituted with about 2-5 electron-withdrawing groups selected from -F, -Cl, -Br, -I, -CN, -CHO (aldehyde), -COR (ketone), and NO. Examples include 2,4-dinitrophenol.

[0105] In another embodiment, the organic acid is a 1,3-dicarbonyl compound containing an acidic (pKa<8) C-H bond. Examples include 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid), cyanuric acid, or barbituric acid.

[0106] In another embodiment, the organic acid is an imide, such as phthalimide. In some embodiments, the phthalimide is a phthalimide substituted with at least one electron-withdrawing substituent.

[0107] In another embodiment, the organic acid is a hydroxamic acid. In some embodiments, the hydroxamic acid can be an aromatic hydroxamic acid containing one hydroxamic functional group directly attached to the aromatic ring. The aromatic ring is selected from the group consisting of a benzene ring, a pyridine ring, a naphthalene ring, a quinoline ring, and a biphenyl ring. An example includes benzhydroxamic acid. Hydroxamic acids can also be aromatic hydroxamic acids containing 1 to 4 sp 3 The hydroxamic acid may be a hydroxamic acid containing a hydroxamic functional group separated from the aromatic ring by a hybridized carbon atom chain. Dihydroxamic acids containing two or more hydroxamic functional groups directly attached to a benzene, pyridine, naphthalene, quinoline, or biphenyl ring system are also contemplated. Additionally, substituted derivatives of the above hydroxamic acids containing electron-donating substituents such as hydroxy, methoxy, amino, alkylamino, dialkylamino, or alkyl groups are also contemplated. Aliphatic dihydroxamic acids containing 6 to 10 carbon atoms, such as suberohydroxamic acid, and unsaturated dihydroxamic acids containing 6 to 10 carbon atoms are also contemplated.

[0108] Organic acids for use in the compositions described herein preferably have an aqueous solubility of 0.1 to 10 g / L, or less than about 20 g / L, at room temperature. In another embodiment, organic acids for use in the compositions described herein have a molar mass of less than 500 grams per mole. In another embodiment, organic acids for use in the compositions described herein are non-polymeric or non-oligomeric. In another embodiment, organic acids for use in the compositions described herein do not have a polymeric or oligomeric backbone and / or are not attached to a polymeric or oligomeric backbone. In another embodiment, the acid has an aqueous solubility of less than about 20 g / L at room temperature and a pKa value of about 3 to 6, more preferably about 3 to 5.5 or about 3.5 to 5.5. In another embodiment, the organic acid is crystalline and has a melting point above about 37°C.

[0109] Compositions comprising a molar excess of an organic acid and a small molecule therapeutic agent are prepared by mixing the organic acid and the therapeutic agent together in a suitable solvent. In some embodiments, the solvent is an aqueous liquid such as a buffer or a water-organic solvent mixture. In preferred embodiments, the organic acid is present in an amount such that the organic acid remains at or above its saturation concentration in the use environment at the end of the delivery period.

[0110] Compositions were prepared using the following organic acids listed in Table 1, and the pH values ​​were measured. [Table 1]

[0111] In embodiments in which the composition is present in a reservoir of a drug delivery device, the device is susceptible to the use environment when placed in the use environment. That is, the use environment and the composition in the device are fluidly connected through pores or a porous membrane in the drug delivery device. The compositions described herein include an organic acid in the form of a suspension or slurry that provides limited aqueous solubility. The organic acid is present in the composition in an amount greater than its saturation concentration, and in another embodiment, the organic acid is present at or above the saturation concentration at the end of the delivery period. Thus, the composition can be used to achieve a desired pH of the suspension or heterogeneous solution of 3.0 to 6.5, preferably 2.75 to 5.75, more preferably 2.8 to 5.6, preferably 2.9 to 5.6, preferably 3.1 to 5.5, 3.2 to 5.5, 3.3 to 5.5, 3.4 to 5.5, 3.5 to 5.5, 3.1 to 5.4, 3.2 to 5.4, 3.3 to 5.4, 3.4 to 5.4, 3.5 to 5.4, 3.1 to 5.3 ... Maintain between 2-5.3, 3.3-5.3, 3.4-5.3, 3.5-5.3, 3.1-5.2, 3.2-5.2, 3.3-5.2, 3.4-5.2, 3.5-5.2, 3.1-5.1, 3.2-5.1, 3.3-5.1, 3.4-5.1, 3.5-5.1, 3.1-5.0, 3.2-5.0, 3.3-5.0, 3.4-5.0, 3.5-5.0, 3.5-5.5 or 3.5-6.0.

[0112] In another embodiment, the organic acid is crystalline and has a melting point above about 37° C. Such organic acids remain in solid form in the in vivo use environment, providing a heterogeneous mixture or suspension of the organic acid in the composition during delivery.

[0113] In another embodiment, the molar excess of the organic acid is between 101% and 900%, between 101% and 800%, between 101% and 700%, between 101% and 600%, between 101% and 500%, between 101% and 400%, between 101% and 300%, between 101% and 200%, between 150% and 1000%, between 150% and 900%, between 150% and 800%, between 150% and 700%, between 150% and 600%, between 150% and 500%, between 150% and 400%, between 150% and 300%, between 150% and 200%. Ranging from 200% to 1000%, 200% to 900%, 200% to 800%, 200% to 700%, 200% to 600%, 200% to 500%, 200% to 400%, 200% to 300%, 150% to 10000% or 200% to 10000%.

[0114] Delivery Device In another aspect, a drug delivery device is provided for administering the compositions or aqueous suspensions described herein. The drug delivery device may be, for example, any implantable device based on diffusion, erosion, or convection systems, such as diffusion systems, osmotic pumps, electrodiffusion systems, electroosmotic systems, electromechanical systems, etc. In some embodiments, a controlled drug delivery device may be utilized for controlled, long-term delivery of a composition over a period of time. The term "controlled drug delivery device" is intended to encompass any device in which the release (e.g., rate, timing of release, duration of administration) of a drug or other desired substance contained in the device is controlled or determined (fully or in part) by the device itself, rather than solely by the environment of use. Some non-limiting examples are described below.

[0115] In some embodiments, the drug delivery device has a housing member defining a reservoir in which the composition and / or aqueous suspension is held. The housing member is of a size and shape suitable for implantation into the body. For subcutaneous implantation using a cannula or trocar, a cylindrical shape is preferred. The outer diameter of the cylindrical housing member is preferably in the range of 2 mm to 6 mm, and the length is in the range of about 10 mm to about 50 mm. In some embodiments, the composition or aqueous suspension is initially present in a dry form in the device's reservoir. For example, an aqueous suspension containing a small molecule therapeutic agent and an organic acid is prepared, followed by spray drying, milling, or freeze-drying to provide a dry form of the aqueous suspension. Alternatively, the individual components in dry form—i.e., the therapeutic agent as a dry solid and the organic acid as a dry solid—can be mixed in the correct proportions, followed by subsequent hydration to provide the desired aqueous suspension. Alternatively, the therapeutic agent and organic acid can be co-dissolved in a suitable organic solvent, such as methanol, ethanol, 1-propanol, 2-propanol, tert-butanol, acetone, 2-butanone, or ethyl acetate, and concentrated to yield a dry powder suitable for resuspension in aqueous media. The dried form of the composition can be tableted or pelleted, incorporated into a device, and hydrated in situ by subcutaneous implantation of the device containing the dried composition, or the composition can be hydrated at the time of subcutaneous implantation by a physician introducing a liquid (e.g., physiological buffer, isotonic saline, phosphate-buffered saline, or aqueous propylene glycol) into a reservoir or matrix containing the composition. The liquid can be provided as part of a kit containing the drug delivery device and a vial containing the hydration liquid.

[0116] Examples of drug delivery devices are provided in Figures 1A-1B. Figure 1A shows device 10 assembled and prepared for implantation into an anatomical compartment of a subject, such as subcutaneously or intraperitoneally. The device consists of a non-erodible housing member 12 defining an internal compartment or reservoir 14. A composition or formulation described herein is contained within the reservoir. Housing member 12 has first and second ends, 16, 18. As seen in Figure 1B, which shows device 10 in its unassembled form, first end 16 is sealed with a fluid-tight end cap 20. End cap 20 may optionally include a porous or semi-permeable membrane or porous septum 22. Second end 18 is attached to a porous membrane, semi-permeable membrane, or porous septum 24.

[0117] Figures 1C-1K show the end cap and end cap subassembly parts of a drug delivery device. The numbered subassembly components shown in Figures 1C-1F are 1 = cap, 2 = porous membrane, 3 = seal, 4 = retention ring, and 5 = drug device reservoir. The numbered subassembly components shown in Figures 1G-1K are 1 = cap, 2 = porous membrane, 3 = seal, 4 = drug delivery device reservoir, and 5 = retention ring.

[0118] The device interior contains a formulation containing a small molecule drug that i) is poorly water soluble at physiological pH (approximately 7.4) and ii) functions as a Bronsted or Lewis base. The drug i) has an aqueous solubility of 0.1-10 g / L or 20 g / L or less at 25°C, and ii) when combined with a stoichiometric excess of an organic acid that is at least partially soluble in the presence of the drug and a physiological buffer, forms a suspension or slurry at a pH (in the aqueous fraction) approximately equal to or less than the pKa of the protonated drug.

[0119] As used herein, the terms "porous membrane" and "porous partition" refer to a structural member having a plurality of pores in the nanometer or micrometer (μm) range, preferably in the 0.1-100 μm or 0.1-200 μm range. The porous partition allows the passage of a therapeutic agent in soluble form from a formulation contained within a reservoir. The porous partition also allows the passage of an organic acid that is part of the formulation in soluble form. In a preferred embodiment, the porous partition retains the therapeutic agent and / or organic acid in an insoluble form. That is, the therapeutic agent and / or organic acid in insoluble form do not pass through the pores of the porous partition. Drug delivery devices are described in detail in U.S. Patent Publication No. 2011 / 0106006, which is incorporated herein by reference.

[0120] Studies were conducted to evaluate the release rate and order of kinetics from drug delivery devices containing compositions consisting of a small molecule therapeutic agent and an organic acid in the device reservoir. As described in Examples 1 and 2, compositions of risperidone with various organic acids and olanzapine with two different organic acids were prepared. Risperidone was selected as a model therapeutic agent due to its potency in water as a neutral free base and its insolubility (>10,000 volumes of water per volume of drug at 20-25°C). In studies with risperidone, the drug was formulated with p-aminobenzoic acid (PABA) at acid:drug ratios of 1:1, 1.5:1, or 2:1 (molar basis) to provide a stoichiometric excess of the organic acid in each formulation. The dried formulations were loaded into the reservoir of the delivery device, hydrated, and incubated with diluted phosphate-buffered saline. Risperidone release was evaluated over a 30-day period, and the results are shown in Figure 2.

[0121] Figure 2 shows the cumulative release of risperidone in milligrams (mg) from drug delivery devices containing heterogeneous aqueous formulations consisting of risperidone and 4-aminobenzoic acid (PABA) at risperidone / PABA molar ratios of 1:1 (diamonds), 1:1.5 (squares), and 1:2 (filled circles) as a function of time (days). In the set of devices containing the 1:2 risperidone / PABA formulation, the membrane surface area decreased by approximately 50% (open circles). The addition of the organic acid, PABA, to the formulation increased the release rate of the therapeutic agent compared to the control formulation and also provided a more stable release rate, approaching zero-order kinetics over the delivery period. Devices containing 1.5:1 or 2:1 PABA / risperidone compositions produced similar release profiles relative to each other, provided the device membrane surface area was held constant. A decrease in membrane surface area of ​​approximately 50% resulted in a corresponding decrease in release rate for systems filled with a 2:1 PABA / risperidone formulation. It is noted that the device with a 1:2 risperidone / PABA molar ratio reaches steady state in approximately 32 days as the device releases all of the drug.

[0122] In summary, the control formulation (risperidone / PABA salt, no excess acid; diamonds) resulted in a slow release rate that decreased over time (i.e., a nonlinear release rate) from devices with the greatest membrane surface area. Formulations containing a 1.5:1 or 2:1 molar ratio of acid to drug (squares and filled circles, respectively) resulted in higher drug delivery rates compared to formulations containing a nonstoichiometric excess of organic acid. Devices containing a 2:1 organic acid / risperidone formulation and approximately half the membrane surface area resulted in approximately half the release rate of devices with 100% available surface area and the same formulation.

[0123] Results from a similar study using olanzapine (Example 2) are shown in Figure 3A, showing the cumulative release of olanzapine in milligrams as a function of time (days) from drug delivery devices containing heterogeneous formulations in the device reservoir consisting of olanzapine and 4-aminobenzoic acid (PABA, squares) or p-toluic acid (diamonds) at a 1:1.5 molar ratio of olanzapine / organic acid, or no acid (circles) as a control. Olanzapine is a poorly water-soluble base. When formulated with a stoichiometric excess (1.5:1 molar ratio) of organic acid (PABA or p-toluic acid), increased and stable release rates are observed. Different organic acids result in substantially different release rates, which may reflect the formulation pH values ​​(4.5-5.0) that are close to the reported pKa values ​​of doubly protonated olanzapine (pKa1 = 5.0; pKa2 = 7.4).

[0124] Figure 3B shows results for another study, similar to that described in Example 2, in which drug delivery devices were loaded with heterogeneous aqueous formulations consisting of olanzapine and 4-aminobenzoic acid (PABA, *) or p-toluic acid (triangles) at a molar ratio of 2:1 olanzapine / organic acid. The in vitro cumulative release of olanzapine in milligrams from the drug delivery devices as a function of time (days) is shown in Figure 3B, with devices containing olanzapine and PABA (*) releasing more rapidly than devices containing a formulation containing p-toluic acid (triangles). As a control, devices containing no acid—i.e., olanzapine only (squares)—released drug slowly over the 15-day study period.

[0125] In summary, little olanzapine free base was released from the control device (circles) during the test or treatment period (total <1 mg). Devices containing formulations containing a 1:1.5 or 1:2 molar ratio of drug to organic acid—PABA (squares) or p-toluic acid (diamonds)—achieved greater release rates than the control device, as well as linear release rates. In the case of olanzapine, different acid additives resulted in substantially different release rates; for example, PABA resulted in faster release than p-toluic acid. In light of this data, one skilled in the art will understand that the release rate can be tailored by the choice of organic acid in the formulation and the molar ratio of drug to organic acid.

[0126] In some embodiments, formulations comprising a small molecule therapeutic agent and an organic acid, with the organic acid present in a stoichiometric amount or in an excess of stoichiometric amount, provide an increase in the release rate of the small molecule therapeutic agent of at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, or 50% compared to formulations of the small molecule therapeutic agent that do not contain organic acid or contain less than stoichiometric organic acid. In some embodiments, the increased release rate is for a period of at least 14 days, at least 2 weeks, at least 30 days, at least 45 days, at least 60 days, at least 90 days, or at least 180 days. In other embodiments, the increased release rate approaches a zero-order release rate during that period.

[0127] Additional studies in which drug delivery devices were formulated to contain dried tablets of risperidone base and PABA (Example 3) or sebacic acid (Example 4) within the device reservoir are described in Examples 3-4. Tablets consisting of risperidone base and organic acid in a 1.5:1 or 1:1 weight ratio were prepared by dissolving the drug and organic acid together in a solvent and drying to remove the solvent. The dried drug-organic acid mixture was milled, and the resulting powder was mixed with a binder (polyvinylpyrrolidone) and a lubricant (stearic acid) and pressed into tablets. The tablets were loaded into drug delivery devices. Immediately prior to in vivo implantation, each device was filled with sterile phosphate-buffered saline (PBS) to hydrate the tablets. The devices were implanted, blood samples were obtained for pharmacokinetic (PK) analysis, and local safety was evaluated for 6 months. Results are shown in Figure 4 for the plasma concentrations of risperidone in ng / mL as a function of time (days) for devices containing an aqueous formulation of risperidone and 4-aminobenzoic acid (PABA, circles) and for devices containing an aqueous formulation of risperidone and sebacic acid (diamonds). For devices loaded with risperidone and PABA (Figure 4, circles), plasma levels of the risperidone active moiety (risperidone and its active metabolite, 9-OH risperidone) peaked within the first few days and then remained at a plasma level of approximately 50 ng / mL for the 6-month implant period. Mass balance analysis revealed that devices explanted after 6 months released the drug at an average rate of 0.70 mg / day and contained an average of 108 mg of unreleased risperidone. These findings indicate that the device operated for an additional 154 days in vivo, for a total operating period of 337 days. To extend the operating period, the device reservoirs were sized and filled with sufficient drug and organic acid for the desired delivery period. For example, to create a 12-month system, the reservoir length is extended by 10% from 40.0 mm to 44.0 mm. Thus, the administration rate can be increased by increasing the diameter of the device or by implanting more than one device per subject.

[0128] For the risperidone and sebacic acid-loaded devices (Figure 4, diamonds), plasma levels of the risperidone active moiety (risperidone and its active metabolite, 9-OH risperidone) peaked within the first few days and then reached a steady state, maintaining plasma levels of 50–60 ng / mL for 6 months. Mass balance analysis revealed that devices explanted after 6 months released the drug at an average rate of 0.80 mg / day and contained an average of 26 mg of unreleased risperidone. These findings indicate that the device operated for an additional 32 days in vivo, for a total operating period of 7 months.

[0129] Example 5 describes a study in which compositions containing various risperidone salts were prepared by dissolving the drug and a two-fold molar excess of an organic acid in methanol. The solvent was removed, and the resulting dried cake was further dried, pulverized, and optionally tableted. The dried drug salt was placed in the reservoir of a drug delivery device. The loaded device was hydrated and placed in 100 mL of PBS at 37°C. Risperidone release was measured by withdrawing an aliquot of the receiving buffer and analyzing it for risperidone concentration. Figure 5 shows the cumulative in vitro release (expressed as a percentage of the total drug load released into the receiving medium) for various risperidone salts (PABA salt, squares; terephthalate, diamonds; sebacate, open diamonds; vanillate, triangles; hippurate, crosses; hydroxyphenylpropionate, open circles; and urate, filled circles). As can be seen, the slopes of the curves are different, indicating different release rates. Terephthalic acid (diamonds) and uric acid (filled circles) addition salts provided insufficient release, achieving only 2.6% and 16% release after 15 days. Risperidone salts of hippuric acid (x) and hydroxyphenylpropionic acid (open circles) achieved 94% and 92% release, respectively, after 15 days. Risperidone salts of sebacic acid (open diamonds), vanillic acid (triangles), and PABA (squares) provided intermediate rates of risperidone release, with approximately 40-60% of the total drug released after approximately 15 days. Thus, in certain embodiments, compositions of a therapeutic agent and an organic acid provide a therapeutic agent release such that at least about 40%, 50%, or 60% of the therapeutic agent is released in vitro after approximately 15 days. In other embodiments, compositions of a therapeutic agent and an organic acid provide a therapeutic agent release such that less than about 30% or less than 40% of the therapeutic agent is released in vitro after approximately 15 days. In another embodiment, the composition of therapeutic agent and organic acid provides a release of the therapeutic agent such that about 40-50% of the therapeutic agent is released in vitro in about 15 days.

[0130] The in vitro release rates of risperidone salts described in Example 5 and shown in Figure 5 are related to the intrinsic aqueous solubility of the acid. The aqueous solubilities of the acids used in Example 5 and their respective risperidone release rates from the device into buffer (expressed as cumulative percent of total risperidone released after 15 days of incubation at 37°C) are listed in Table 2. These data are plotted in Figure 6. The highest risperidone release rates occur when the drug is combined with an acid having an intrinsic aqueous solubility of approximately 1.0 to 6.0 mg / mL. Maximum release is observed for risperidone salts of hippuric acid and 3-(4-hydroxyphenyl)propionic acid, which exhibit aqueous solubilities of approximately 2.5 to 4.0 mg / mL at approximately 25°C. This data indicates that acids with aqueous solubilities less than approximately 1 g / L do not maintain a sufficiently low pH within the device, while acids with aqueous solubilities substantially greater than 6 g / L release from the device too rapidly and therefore fail to sustain drug release over an extended period of time. [Table 2]

[0131] The in vitro release rates of the risperidone salts listed in Example 5 are also related in part to the pH of the saturated aqueous solution of the acid. The pH at saturation of the acids used in Example 5 and their respective risperidone release rates (expressed as cumulative percent of total risperidone released after 15 days of incubation at 37°C) are shown in Figure 7. The highest risperidone release rates occur when the drug is combined with an acid exhibiting a pH at saturation of approximately 2.0 to 3.7. Maximum release is observed for risperidone salts of hippuric acid and 3-(4-hydroxyphenyl)propionic acid, which exhibit pH values ​​of 2.6 and 3.0, respectively. Thus, in some embodiments, the composition comprises a therapeutic agent and an organic acid having a saturated pH in aqueous solution of about 2.0 to 3.7, or about 2.1 to 3.6, about 2.1 to 3.5, about 2.2 to 3.5, about 2.2 to 3.4, about 2.3 to 3.4, about 2.4 to 3.3, about 2.5 to 3.2, about 2.5 to 3.1, about 2.5 to 3.0, about 2.6 to 3.2, about 2.6 to 3.1, or about 2.6 to 3.0.

[0132] Other drug delivery devices are known in the art. The compositions described herein are useful for a variety of devices, including devices containing a drug reservoir for holding a small molecule therapeutic agent and an organic acid formulation, and devices having a substrate or matrix capable of holding or containing the formulation. Controlled drug release devices suitable for the present invention generally provide for delivery of a drug from the device to a selected site in a subject in a selected or otherwise patterned amount and / or rate. The drug delivery device must be capable of containing an amount of formulation sufficient to provide a therapeutically effective amount of the small molecule over a treatment period. The delivery period will vary depending on the therapeutic agent, the condition being treated, and the individual patient. In certain embodiments, the delivery period, also referred to herein as a sustained period, contemplates a period of at least about 2 weeks to about 6 months. In other embodiments, a sustained period contemplates a period of at least about 2 weeks, or at least about 3 weeks, or at least about 4 weeks to about 6 months, or about 4 months, or about 3 months. In other embodiments, a sustained period contemplates a period of at least about 15 days, or at least about 21 days, or at least about 30 days, or at least about 45 days, or at least about 60 days. In other embodiments, periods of about 2 hours to about 72 hours, about 4 hours to about 36 hours, about 12 hours to about 24 hours, about 2 days to about 30 days, about 5 days to about 20 days, about 7 days or more, about 10 days or more, about 100 days or more; about 1 week to about 4 weeks, about 1 month to about 24 months, about 2 months to about 12 months, about 3 months to about 9 months, about 1 month or more, about 2 months or more, or about 6 months or more are contemplated.

[0133] Accordingly, in another embodiment, an implantable device is contemplated, comprising: (i) a therapeutic agent in an amount to provide a substantially zero-order release of the therapeutic agent in an amount that provides a therapeutic effect for a period of at least about 30 days; and (ii) a reservoir containing a formulation of a small molecule therapeutic agent, the organic acid (a) maintaining the pH of the formulation when hydrated in a use environment of pH 3.0 to 6.0 during the delivery period, (b) being present in a stoichiometric (molar) excess amount relative to the therapeutic agent, and (c) being present when hydrated in an amount that approximately equals or exceeds its saturation concentration in the formulation at the end of the delivery period.

[0134] In another embodiment, an implantable device is contemplated, comprising: (i) a therapeutic agent in an amount to provide substantially zero-order release of the therapeutic agent in an amount that provides a therapeutic effect for a period of at least about 30 days; and (ii) a formulation of a small molecule therapeutic agent comprising an organic acid that (a) maintains a pH of the formulation when hydrated in its use environment that is about equal to or less than the pKa of the protonated drug during the delivery period; (b) is present in a stoichiometric (molar) excess amount relative to the therapeutic agent; and (c) is present when hydrated in an amount about equal to or greater than its saturation concentration in the formulation at the end of the delivery period.

[0135] In some embodiments, the formulation containing a stoichiometric excess of an organic acid is in a dry form. For example, the dry formulation can be in a reservoir as a powder, tablet, or film. When used in vitro or in vivo, the device absorbs fluid from the surrounding environment to hydrate the dry formulation, thus forming an aqueous suspension in situ containing both particles of the salt form of the therapeutic agent and an excess amount of insoluble particles.

[0136] The drug delivery device can be implanted at any suitable implantation site using methods and devices known in the art. As described below, an implantation site is a site within a subject's body where the drug delivery device is introduced and positioned. Implantation sites include, but are not necessarily limited to, subdermal, subcutaneous, intramuscular, or other suitable sites within a subject's body. Subcutaneous implantation sites are preferred due to the convenience of implanting and removing the drug delivery device. Typical subcutaneous delivery sites include subcutaneously in the arm, shoulder, neck, back, or leg. Sites within body cavities are also suitable implantation sites. Methods for implanting or otherwise attaching drug delivery devices for subcutaneous delivery of drugs are known in the art. Generally, attachment of the drug delivery device is achieved using methods and tools known in the art and is performed under sterile conditions with at least some local or general anesthesia administered to the subject.

[0137] Treatment method In other aspects, methods of treatment using the compositions and devices described herein are contemplated. In certain embodiments, methods for sustained, controlled delivery of central nervous system drugs are contemplated, providing a composition described herein or a delivery device comprising the composition.

[0138] In another embodiment, a method for sustained, controlled delivery of an antipsychotic drug is contemplated, providing a composition described herein or a delivery device comprising the composition.

[0139] In another embodiment, a method is contemplated for maintaining therapeutic plasma levels of an antipsychotic drug, thereby delaying relapse in a stable, previously medicated patient by at least four weeks.

[0140] Based on the foregoing, the compositions described herein, comprising a small molecule therapeutic agent and an organic acid, provide release of the therapeutic agent for an extended period—at least about 14 days or at least about 30 days—at a constant rate approaching a zero-order release rate during that period. The compositions contain a sufficient amount of therapeutic agent for a therapeutic dose of the drug during that period, and an amount of organic acid to maintain (i) a concentration of the protonated therapeutic agent at or near its saturation concentration in the hydrated composition during that period, and / or (ii) a concentration of the organic acid at or above its saturation concentration in the hydrated composition at the end of the delivery period. The near-saturation concentration of drug is relative to the aqueous phase of the composition. In some embodiments, the composition is retained within a drug delivery system (or device) and, when placed in a use environment (e.g., a subcutaneous implant site, e.g., plasma or interstitial fluid having a constant pH of about 7.4), provides a constant concentration gradient between the device interior and its use environment, facilitating a constant release rate (approximately zero-order) of the therapeutic agent during that period. [Example]

[0141] III. Working Examples The following examples are aiding in nature and are not intended to be limiting.

[0142] Example 1 Formulations containing risperidone and organic acids as small molecule therapeutic agents. p-Aminobenzoic acid (PABA) and risperidone were blended at acid:drug ratios of 1:1, 1.5:1, or 2:1 (molar basis), compressed with lactose binder (13%), and loaded into delivery devices with 0.1 micron polyvinylidene fluoride (DURAPORE®) membranes. In some devices, approximately 50% of the available membrane surface area was blocked to measure the effect of surface area on release rate. All devices were vacuum-filled with phosphate buffer and transferred to bottles containing an equal volume (approximately 100 mL) of buffer. The sealed bottles were then incubated at 37°C, and aliquots (approximately 500 μL) of receiving buffer were withdrawn at selected time points, and the released drug was quantified by high-performance liquid chromatography (HPLC). Risperidone release is shown in Figure 2.

[0143] Example 2 Formulations containing olanzapine organic acids as small molecule therapeutic agents. Olanzapine was blended with p-aminobenzoic acid (PABA) or p-toluic acid at a 1.5:1 (molar) acid:drug ratio, compressed with lactose binder (13%), and loaded into a delivery device with a 0.1 micron polyvinylidene fluoride (DURAPORE®) membrane. All devices were vacuum-filled with phosphate buffer and transferred to a bottle containing an equal volume (approximately 100 mL) of buffer. The sealed bottle was then incubated at 37°C, and aliquots (approximately 500 μL) of receiving buffer were withdrawn at selected time points, and the released drug was quantified by high-performance liquid chromatography (HPLC). Olanzapine release is shown in Figure 3A.

[0144] Example 3 In vivo pharmacokinetics of 12-month implantable devices filled with formulations containing risperidone and para-aminobenzoic acid Risperidone base (75.00 g, 0.1827 mol) was weighed and transferred to a 1.0 L medium bottle containing a stir bar. PABA (50.00 g, 0.3646 mol) was weighed and added to the bottle containing risperidone. Approximately 750 mL of methanol was then added. The bottle containing the formulation was sealed and mixed with a magnetic stirrer. The mixture was visually inspected for complete dissolution of the drug and acid, and the stir bar was removed. The solution was then directly filtered into a rotary evaporator (0.45 μ DURAPORE®) and subjected to a primary drying step under vacuum until most of the solvent had evaporated, with the start and end times recorded. After completion of rotary (primary) drying, the vacuum was released, and the resulting foam was briefly reduced by hand before being subjected to secondary drying under high vacuum.

[0145] After secondary drying, all mixtures were transferred to a glove box for milling. The formulations were placed in a milling container equipped with a dry-matter milling blade and milled using a blender base at 20,000 rpm. A custom-made polypropylene sleeve was used around the container with dry ice to prevent the formulation from overheating. The mixture was milled for five cycles. The resulting powder was mixed with 12% by weight of polyvinylpyrrolidone (PVP approx. 40K, Sigma Aldrich) as a binder and 1% by weight of stearic acid (1% of the final powder weight, Sigma Aldrich) as a lubricant. Tablets were produced using a tablet press and custom-made die set obtained from Vanguard Pharmaceutical Machinery (Spring, TX). The die used for tableting had a diameter that matched the inner diameter (4.30 mm) of the device reservoir.

[0146] The drug delivery devices were fabricated from titanium, measuring 40.0 mm in length, and contained an internal reservoir. The cap subassemblies (Figures 1C-1K) contained DURAPORE® porous membrane (0.1 micron, Millipore Corp). The assembled caps were attached to the device reservoirs and weighed along with another assembled cap to obtain the weight of the empty device. Each reservoir subassembly (reservoir + one cap) was manually filled with tablets, capped with a second cap subassembly, and re-weighed to obtain the tablet fill weight. The average fill weight of each device was 460 mg (equivalent to 230 mg of risperidone as free base).

[0147] After weighing, the assembled devices were individually placed into 20 mL lyophilization vials. The vials were loosely capped with igloo-type rubber septa and placed in a lyophilizer equipped with a stopper tray system. Prior to sealing, the air space within each device and vial was evacuated to a vacuum pressure of <1 Torr for at least 30 minutes.

[0148] During manufacturing, efforts were made to maintain low bioburden levels during compounding, device assembly, and trocar assembly. Finally, terminal sterilization of both the filled devices and their implants was performed using electron beam sterilization at a fractionated dose of 25 kGy.

[0149] Immediately prior to in vivo implantation, each device was filled with sterile phosphate-buffered saline (PBS) using a 20 mL syringe equipped with a blunt fill needle. Upon needle insertion through the rubber septum, the vacuum within the vial rapidly drew the hydration solution into the vial and into the device without any manual force on the plunger. After hydration, the needle was withdrawn from the septum, and the device was allowed to stand for approximately 10 minutes. Each device was then retrieved from its vial, wiped with tissue to absorb any extraneous liquid, and weighed. The device was implanted subcutaneously on one side of the animal's back using a custom-made implantation tool, and the incision was closed with sutures or surgical adhesive. Whole blood samples were obtained for pharmacokinetic (PK) analysis, and local safety was assessed for 6 months. The implants were well tolerated by all animals. PK results for the first 6 months are shown in Figure 4. Plasma levels of the risperidone active moiety (risperidone and its active metabolite, 9-OH risperidone) peaked within the first few days and then reached steady-state plasma levels of 50–60 ng / mL over the 6-month implantation period. Mass balance analysis revealed that devices explanted after 6 months released the drug at an average rate of 0.70 mg / day and contained an average of 108 mg of unreleased risperidone. These findings indicate that the device functioned in vivo for an additional 154 days, for a total operating period of 337 days. To extend the operating period, the device reservoir can be sized and filled with sufficient drug and organic acid for the desired delivery rate. For example, to create a 12-month system, the reservoir length is extended 10% from 40.0 mm to 44.0 mm. Thus, the administration rate can be increased by increasing the device diameter or by implanting more than one device per subject.

[0150] Example 4 In vivo pharmacokinetics of a 7-month implantable device filled with a formulation containing risperidone and sebacic acid Risperidone base (75.00 g, 0.1827 mol) was weighed and transferred to a 1.0 L media bottle containing a stir bar. Sebacic acid (74.91 g, 0.3704 mol) was weighed and added to the bottle containing risperidone. Approximately 75 mL of methanol was then added. The bottle containing the formulation was sealed and mixed with a magnetic stirrer. The mixture was visually inspected for complete dissolution of the drug and acid, and the stir bar was removed. The mixture was dried, granulated, compressed into tablets, filled into device reservoirs, and terminally sterilized as described in Example 3. The device reservoir size was 3.6 mm inner diameter, 5.21 mm outer diameter, and 41.4 mm long. Five devices were filled with an average of 400 mg tablets (equivalent to 167 mg of risperidone base).

[0151] Each device was then retrieved from its vial, wiped with tissue to absorb any extraneous fluid, and weighed. The animals were implanted subcutaneously on one side of their backs using a custom-made implantation tool, and the incision was closed with sutures or surgical glue. Whole blood samples were obtained for pharmacokinetic (PK) analysis to assess local safety for 6 months. The implants were well tolerated by all animals. PK results for the first 6 months are shown in Figure 4.

[0152] Example 5 In vitro release of risperidone from devices filled with various risperidone addition salts. Various risperidone salts were prepared by dissolving the drug and a two-fold molar excess of the selected acid in methanol. The solvent was removed under reduced pressure. The dried cake was further dried, crushed, tableted (in some cases), filled into reservoirs, capped, and evacuated vials as described in Example 3. The filled devices were hydrated and placed in 100 mL of PBS at 37°C on an orbital rotor (50 rpm). Aliquots of the receiving buffer were analyzed (spectrophotometer or HPLC) for risperidone concentration. Figure 5 shows the cumulative in vitro release (expressed as a percentage of the total drug load released into the receiving medium) for various risperidone salts. Furthermore, the present invention includes the following aspects. Item 2. A composition comprising an aqueous suspension comprising a therapeutic agent (i) having an aqueous solubility of less than 1.0 g / L at room temperature, and (ii) being an organic base, and an organic acid (i) having an aqueous solubility of 0.1 to 10 g / L at room temperature, (ii) having a molar mass of less than 500 grams per mole, (iii) being present in a stoichiometric (molar) excess amount compared to the therapeutic agent, and (iv) maintaining the pH of the suspension in its use environment of pH 3.0 to 6.5 for a period of at least about 30 days. Item 3. The composition according to Item 1, wherein a saturated aqueous solution of the organic acid has a pH value approximately equal to or less than the pKa of the protonated therapeutic agent. Item 4. The composition according to Item 1 or 2, wherein at the end of the period, the organic acid is present in an amount approximately equal to or greater than its saturation concentration. Item 5. The composition according to any one of Items 1 to 3, wherein the organic acid is present in a 105% to 1000% stoichiometric excess amount compared to the therapeutic agent. Item 6. The composition according to any one of Items 1 to 4, wherein the organic acid is crystalline and has a melting point above about 37°C. Item 7. The composition according to any one of Items 1 to 5, wherein the therapeutic agent is used to treat a disease of the central nervous system. Item 8. The composition according to Item 6, wherein the therapeutic agent is an antipsychotic drug. Item 9. The composition according to Item 6 or 7, wherein the therapeutic agent is risperidone, olanzapine, asenapine, aripiprazole, or brexpiprazole. Item 10. The composition according to any one of Items 1 to 8, wherein the aqueous suspension contains a buffer solution. Item 11. The composition according to Item 9, wherein the buffer is phosphate buffered saline. Item 12. The composition according to any one of Items 1 to 10, wherein the organic acid is an aromatic carboxylic acid. Item 13. The composition according to any one of Items 1 to 10, wherein the organic acid is a carboxylic acid having a water solubility of about 2 mg / mL to 8 mg / mL at a temperature of 25°C to 37°C. Item 14. The composition according to any one of Items 1 to 10, wherein the organic acid is a carboxylic acid having a pH of about 2.0 to 3.7 at a saturated concentration at a temperature of 25°C to 37°C. Item 15. The composition according to any one of Items 11 to 13, wherein the carboxylic acid is a carboxylic acid having a carboxylic acid group bonded to an unsubstituted benzene ring or pyridine ring. Item 16. The composition according to Item 14, wherein the acid is selected from the group consisting of benzoic acid, picolinic acid, nicotinic acid, and isonicotinic acid. Item 17. The composition according to Item 14, wherein the carboxylic acid is a carboxylic acid having a benzene ring and one electron-donating group having antioxidant properties. Item 18. The composition of item 16, wherein the carboxylic acid is selected from the group consisting of o-anisic acid, m-anisic acid, p-anisic acid; p-aminobenzoic acid (PABA), o-aminobenzoic acid (anthranilic acid), o-toluic acid, m-toluic acid, p-toluic acid, and salicylic acid. Item 19. The composition according to Item 14, wherein the carboxylic acid is a carboxylic acid having one benzene ring and two electron-donating groups having antioxidant properties. Item 20. The composition according to Item 18, wherein the carboxylic acid is vanillic acid. Item 21. The composition according to Item 14, wherein the carboxylic acid is a carboxylic acid having at least two carboxylic acid groups attached to a benzene ring. Item 22. The composition according to Item 20, wherein the carboxylic acid is phthalic acid. Item 23. The composition according to Item 14, wherein the carboxylic acid is a carboxylic acid having a carboxylic acid group bonded to a naphthalene ring or a quinoline ring. Item 24. The composition according to Item 22, wherein the carboxylic acid is selected from the group consisting of 1-naphthoic acid, 2-naphthoic acid, quinaldic acid, 3-quinolinecarboxylic acid, 4-quinolinecarboxylic acid, 5-quinolinecarboxylic acid, 6-quinolinecarboxylic acid, 7-quinolinecarboxylic acid, and 8-quinolinecarboxylic acid. Item 25. The composition according to Item 14, wherein the carboxylic acid is a carboxylic acid having an electron-donating group selected from the group consisting of hydroxy, methoxy, amino, alkylamino, dialkylamino, and alkyl. Item 26. The composition of item 24, wherein the carboxylic acid is selected from the group consisting of 6-hydroxy-2-naphthoic acid, 6-hydroxy-3-naphthoic acid, 8-hydroxy-2-quinolinecarboxylic acid, and 8-hydroxy-7-quinolinecarboxylic acid. Item 27. The composition of item 14, wherein the carboxylic acid is a carboxylic acid having one or two carboxylic acid groups directly attached to the biphenyl ring system. Item 28. The composition of item 26, wherein the carboxylic acid is selected from the group consisting of 2-phenylbenzoic acid, 3-phenylbenzoic acid, 4-phenylbenzoic acid, and diphenic acid. Item 29. The composition according to Item 14, wherein the carboxylic acid is a carboxylic acid having one further electron-donating substituent in addition to the hydroxyl group of the carboxylic acid moiety. Item 30. The composition according to Item 28, wherein the carboxylic acid is selected from the group consisting of 4'-hydroxy-4-biphenylcarboxylic acid, 4'-hydroxy-2-biphenylcarboxylic acid, 4'-methyl-4-biphenylcarboxylic acid, 4'-methyl-2-biphenylcarboxylic acid, 4'-methoxy-4-biphenylcarboxylic acid, and 4'-methoxy-2-biphenylcarboxylic acid. Item 31. Organic acids have 1 to 4 sp 3 11. The composition of any one of items 1 to 10, wherein the organic acid comprises a carboxylic acid functional group separated from a benzene ring, a pyridine ring, a naphthalene ring, or a quinoline ring by a chain of hybridized carbons. Item 32. The composition according to Item 30, wherein the carboxylic acid is phenylacetic acid or 3-phenylpropionic acid. Item 33. The composition according to any one of Items 1 to 10, wherein the organic acid is an aliphatic dicarboxylic acid having 4 to 8 carbon atoms between the carboxylic acid groups. Item 34. Carboxylic acid is adipic acid (CH 2 ) 4 (COOH) 2 ), pimelic acid (HO 2 C(CH 2 ) 5 CO 2 H), suberic acid (HO 2 C(CH 2 ) 6 CO 2 H), azelaic acid (HO 2 C(CH 2 ) 7 CO 2 H) and sebacic acid (HO 2 C(CH 2 ) 8 CO 2 Item 33. The composition according to item 32, selected from the group consisting of: Item 35. The composition according to any one of Items 1 to 10, wherein the organic acid is an unsaturated or polyunsaturated dicarboxylic acid containing 4 to 10 carbon atoms. Item 36. The composition of Item 34, wherein the carboxylic acid is selected from the group consisting of fumaric acid, trans,trans-muconic acid, cis,trans-muconic acid, and cis,cis-muconic acid. Item 37. The composition according to any one of Items 1 to 10, wherein the organic acid is cis-cinnamic acid or trans-cinnamic acid. Item 38. The composition of item 36, wherein the carboxylic acid is trans-cinnamic acid having one or two electron-donating groups selected from hydroxy, methoxy, amino, alkylamino, dialkylamino, or alkyl groups. Item 39. The composition according to Item 37, wherein the trans-cinnamic acid is selected from the group consisting of o-coumaric acid, m-coumaric acid, p-coumaric acid, o-methylcinnamic acid, m-methylcinnamic acid, p-methylcinnamic acid; o-methoxycinnamic acid, m-methoxycinnamic acid and p-methoxycinnamic acid, and ferulic acid. Item 40. The composition according to any one of Items 1 to 10, wherein the organic acid is a 1,3-dicarbonyl compound containing an acidic (pKa<8) C-H bond. Item 41. The composition according to Item 39, wherein the organic acid is 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid), cyanuric acid, or barbituric acid. Item 42. The composition according to any one of Items 1 to 10, wherein the organic acid is an imide. Item 43. The composition according to Item 41, wherein the imide is phthalimide or a substituted phthalimide. Item 44. The composition of item 42, wherein the substituted phthalimide has at least one electron-withdrawing substituent. Item 45. The composition according to any one of Items 1 to 10, wherein the organic acid is a hydroxamic acid. Item 46. The composition of item 44, wherein the hydroxamic acid is an aromatic hydroxamic acid containing one hydroxamic functional group directly attached to the aromatic ring. Item 47. The composition according to Item 45, wherein the aromatic ring is selected from the group consisting of a benzene ring, a pyridine ring, a naphthalene ring, a quinoline ring, and a biphenyl ring. Item 48. The composition according to Item 45 or 46, wherein the hydroxamic acid is benzhydroxamic acid. Item 49. The composition of item 44, wherein the hydroxamic acid is a hydroxamic acid containing at least one hydroxamic functional group separated from an aromatic ring by a chain of 1 to 4 saturated carbon atoms. Item 50. The composition according to Item 48, wherein the aromatic ring is selected from the group consisting of a benzene ring, a pyridine ring, a naphthalene ring, a quinoline ring, and a biphenyl ring. Item 51. The composition of item 44, which is a dihydroxamic acid containing two or more hydroxamic acid functional groups directly attached to a benzene ring, a pyridine ring, a naphthalene ring, a quinoline ring, or a biphenyl ring system. Item 52. The composition of any one of Items 44 to 50, wherein the hydroxamic acid is a hydroxamic acid substituted with an electron-donating substituent selected from hydroxy, methoxy, amino, alkylamino, dialkylamino, and alkyl groups. Item 53. The composition according to Item 44, wherein the hydroxamic acid is an aliphatic dihydroxamic acid containing 6 to 10 carbon atoms. Item 54. The composition of Item 52, wherein the hydroxamic acid is suberohydroxamic acid. Item 55. The composition according to Item 44, wherein the hydroxamic acid is an unsaturated dihydroxamic acid containing 6 to 10 carbon atoms. Item 56. The composition of any one of items 1 to 10, wherein the organic acid comprises an aromatic ring and a carboxylic acid functional group. Item 57. The composition of item 55, wherein the carboxylic acid is selected from the group consisting of 3-phenylpropionic acid, cinnamic acid, hydroxy derivatives of cinnamic acid, methoxy derivatives of cinnamic acid, nicotinic acid, benzoic acid, amino derivatives of benzoic acid, methoxy derivatives of benzoic acid, and phthalic acid. Item 58. The composition according to Item 56, wherein the hydroxy derivative of cinnamic acid is m-coumaric acid or p-coumaric acid. Item 59. The composition according to Item 57, wherein the p-coumaric acid is trans-p-coumaric acid. Item 60. The composition according to Item 56, wherein the methoxy derivative of cinnamic acid is p-methoxycinnamic acid or m-methoxycinnamic acid. Item 61. The composition according to Item 56, wherein the amino derivative of benzoic acid is 2-aminobenzoic acid (anthranilic acid) or 4-aminobenzoic acid (para-aminobenzoic acid; PABA). Item 62. The composition according to Item 56, wherein the methoxy derivative of benzoic acid is 4-methoxybenzoic acid (p-anisic acid), o-anisic acid, or m-anisic acid. Paragraph 63. The composition of any one of paragraphs 1 to 61, wherein the amount of small molecule therapeutic agent is sufficient to provide treatment for at least 30 days. Item 64. The composition according to any one of items 1 to 62, wherein the composition is in a dry form. Item 65. A device comprising the composition according to any one of items 1 to 63, which is designed for subcutaneous implantation in a mammal. Item 66. An implantable device comprising: (i) a small molecule therapeutic agent in an amount sufficient to provide a therapeutic effect for a period of at least about 30 days; (ii) an organic acid that, when hydrated, maintains the pH of the formulation in its use environment of pH 3.0 to 6.5 during the delivery period; and (iii) a reservoir containing a formulation of the small molecule therapeutic agent having a release rate that provides a therapeutic dose of the agent during the period. Item 67. The device of Item 63, wherein a saturated aqueous solution of the organic acid has a pH value approximately equal to or less than the pKa of the protonated therapeutic agent. Item 68. The device according to Item 65, wherein the formulation is in a dry form. Item 69. The device according to Item 66, wherein the formulation is a powder, tablet, or film. Clause 70. The device of clause 66 or clause 68, wherein the formulation is hydrated in the presence of an aqueous solution to form an aqueous suspension. Paragraph 71. The device of any one of paragraphs 65 to 69, wherein the small molecule therapeutic agent is released from the device at a rate that provides a therapeutically effective effect over a period of time. Item 72. The device according to any one of Items 65 to 70, wherein the organic acid has a water solubility of 0.1 to 10 g / L and a pKa of 3 to 6. Item 73. The device according to any one of items 65 to 71, wherein the organic acid has a melting point of greater than about 37°C. Item 74. A method for sustained, controlled delivery of a small molecule therapeutic agent, comprising providing a composition according to any one of items 1 to 64 or a device according to any one of items 64 to 72. Item 75. A method for sustained, controlled delivery of a small molecule therapeutic agent used to treat a disease of the central nervous system, comprising providing a composition according to any one of items 1 to 64 or a device according to any one of items 64 to 72. Item 76. A method for treating a mental disorder, comprising providing a composition according to any one of items 1 to 64 or a device according to any one of items 64 to 72. Item 77. The method of Item 75 for treating schizophrenia.

Claims

1. A subcutaneous implantable device, a reservoir containing an aqueous suspension; and a porous partition wall containing a plurality of pores having diameters between 0.1 and 100 microns; The aqueous suspension comprises: (1) a therapeutic agent selected from the group consisting of risperidone, olanzapine, paliperidone, asenapine, aripiprazole, and brexpiprazole; and (2) an organic acid selected from the group consisting of o-anisic acid, m-anisic acid, p-anisic acid; p-aminobenzoic acid (PABA), o-aminobenzoic acid (anthranilic acid), o-toluic acid, m-toluic acid, p-toluic acid, hippuric acid, vanillic acid, salicylic acid, and hydroxyphenylpropionic acid, present in a stoichiometric (molar) excess amount relative to the therapeutic agent; The porous partition wall (i) allowing passage of said therapeutic agent in soluble form from an aqueous suspension contained within a reservoir; (ii) allowing the passage of the organic acid that is part of the aqueous suspension in soluble form; and (iii) retaining the therapeutic agent and / or the organic acid in an insoluble form; the aqueous suspension has a pH of 3.0 to 6.5 after a period of at least 30 days in an in vivo subcutaneous use environment at human body temperature, and the organic acid is present in an amount that is about equal to or greater than the saturation concentration in the use environment. device.

2. The device described in claim 1, wherein the pores have a diameter of approximately 0.1 microns.

3. 3. The device of claim 1 or 2, wherein the device is designed for subcutaneous implantation in a mammal.

4. The device of any one of claims 1 to 3, wherein a saturated aqueous solution of the organic acid has a pH value about equal to or less than the pKa of the protonated therapeutic agent.

5. The device of any one of claims 1 to 4, wherein the organic acid is present in a stoichiometric excess of 105% to 1000% compared to the therapeutic agent.

6. The device of any one of claims 1 to 5, wherein the organic acid is crystalline and has a melting point above 37°C.

7. The device according to any one of claims 1 to 6, wherein the aqueous suspension is in a dry form.

8. The device according to any one of claims 1 to 7, wherein the aqueous suspension is a powder, a tablet or a film.

9. The device of any one of claims 1 to 8, wherein the therapeutic agent is risperidone.

10. The device according to any one of claims 1 to 9, wherein the carboxylic acid is an amino derivative of benzoic acid or a methoxy derivative of benzoic acid.

11. The device of claim 10, wherein the amino derivative of benzoic acid is 2-aminobenzoic acid (anthranilic acid) or 4-aminobenzoic acid (para-aminobenzoic acid; PABA).

12. The device of any one of claims 1 to 11, wherein the therapeutic agent is released from the device at a rate that provides a therapeutically effective effect over that period of time.

13. The device of any one of claims 1 to 12, wherein the organic acid has a pKa of 3 to 6.

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