Compositions with enhanced deposition of surfactant-soluble antidandruff agents

Abstract

The present invention provides a hair care composition comprising from about 8% to about 25% of one or more surfactants and from about 0.01% to about 10% of one or more surfactant-soluble agents, the composition having a partial soluble agent concentration (α) of 0.5 to 1.0, where "α" is [Equation 1] TIFF2022504965000031.tif6128 (where C is the surfactant-soluble agent concentration, C s i is the surfactant concentration, and K s i is the solubilizing capacity of each type of surfactant (e.g., in ppm of octopirox / wt% of surfactant), and K s i can be readily determined for any combination of surfactant and surfactant-soluble agent.

Description

[Technical Field]

[0001] The present invention relates to rinse-off personal care compositions, and it has surprisingly been discovered that deposition of surfactant-soluble agents can be greatly enhanced by increasing the concentration of the partially soluble agent. [Background technology]

[0002] Dandruff conditions adversely affect a large percentage of people, and many products promise to alleviate the condition. While leave-on treatments were once common, many consumers prefer rinse-off treatment products, such as shampoos, due to their ease of application, time savings, and overall convenience. An inherent problem with rinse-off treatments is that the cleansing event is quick and efficient, making it difficult to accomplish anything more than simple cleansing during the process. For many years, this challenge has been addressed by creating shampoo formulations that use cationic polymers with anionic surfactants to form coacervates. These formulations have been combined with particulate agents, and coacervates have been used to increase the deposition of insoluble particulate anti-dandruff agents.

[0003] The long-standing approach to alleviating dandruff symptoms by delivering insoluble particles via coacervates that form rinse-off coatings has several inherent limitations. First, coacervate-assisted delivery typically results in indiscriminate particle deposition on both the scalp and hair, which can result in undesirable hair aesthetics. Second, particulate anti-dandruff agents opacify the product, limiting visual product aesthetics. Third, much of the deposited particulate anti-dandruff agent is wasted. When deposited as discrete particles, the scalp surface area occupied by the anti-dandruff agent is low and discontinuous, requiring the particulates to dissolve onto a substrate to actually be active against biological targets, which can be difficult or impossible given the environmental and solubility properties of particulate anti-dandruff agents. To improve efficacy, very high formulated anti-dandruff agent use levels are often employed, which is costly and can only exacerbate the problem of poor product aesthetics.

[0004] Although many of the limitations associated with particulate anti-dandruff agents can be overcome by switching to soluble anti-dandruff agents in formulations, it has been difficult to achieve the desired high level of anti-dandruff agent deposition on desired biological substrates.To combat deposition problems, formulators can teach methods to create soluble anti-dandruff agent particulates (for example, encapsulation of soluble anti-dandruff agents).These methods improve the deposition of soluble anti-dandruff agents, but then the spatial distribution and dissolution problems associated with the deposition of particulate anti-dandruff agents reappear.

[0005] In addition to the adhesion difficulties associated with the use of soluble anti-dandruff agents in rinse-off applications, another major constraint on product development has been measurement capabilities. Often, in vivo tests are performed to measure the amount and / or activity of anti-dandruff agents deposited on the scalp / skin. Compared with analytical measurements in in vitro tests or ex vivo tests, these in vivo tests are more expensive and time-consuming, and have a limited range of material evaluation. If the solution regarding the adhesion and / or activity of anti-dandruff agents can be reliably obtained in one of these other test procedures, it will enable both more extensive and more efficient formulation screening during development. This is also true for other agents where substrate adhesion level is important. Summary of the Invention [Means for solving the problem]

[0006] The present invention provides a hair care composition comprising from about 8% to about 25% of one or more surfactants and from about 0.01% to about 10% of one or more surfactant-soluble agents, the composition having a partial soluble agent concentration (α) of 0.5 to 1.0, where "α" is

[0007]

number

[0008] In response to the problems identified in the background art, the present invention relates to personal care compositions in the form of rinse-off cleansers that include a combination of a surfactant and a surfactant-soluble agent, and have a partial soluble agent concentration (α) of 0.5 to 1.0. Personal care compositions with such partial soluble agent concentrations exhibit increased deposition and high activity. This unexpected soluble agent deposition benefit allows for broad formulation flexibility.

[0009] As can be seen in the comparative examples, the high levels of surfactant-soluble agent deposited from the rinse-off formulations are not achievable from a simple surfactant matrix without departing from the claimed levels of partial soluble agent concentration. [Brief explanation of the drawings]

[0010] [Figure 1] Partially soluble agent concentration versus in vivo detergent-soluble agent deposition for Examples 17-31. DETAILED DESCRIPTION OF THE INVENTION

[0011] Unless otherwise specified, all percentages and ratios used herein are by weight of the total composition. Unless otherwise specified, it is understood that all measurements are made at ambient conditions, where "ambient conditions" means conditions at about 25°C, under about 1 atmosphere, and at about 50% relative humidity. All numerical ranges are inclusive of narrower ranges. The stated upper and lower range limits are combinable to create additional ranges not expressly stated.

[0012] The compositions of the present invention can comprise, consist essentially of, or consist of the essential and optional ingredients described herein. As used herein, "consisting essentially of" means that the composition or component may include additional ingredients, but only if the additional ingredients do not materially alter the basic and novel characteristics of the claimed composition or method.

[0013] "Applying" or "application" as used in reference to a composition means applying or spreading a composition of the present invention onto keratinous tissue, such as hair.

[0014] While the specification concludes with the claims, which particularly point out and distinctly claim the invention, it is believed the present invention will be better understood from the following description. As used herein, the term "fluid" includes liquids and gels. As used herein, articles such as "a" and "an," when used in the claims, are understood to mean one or more of what is claimed or described. As used herein, "comprising" means that other steps and other ingredients that do not affect the end result can be added. This term encompasses the terms "consisting of" and "consisting essentially of." As used herein, "mixture" means including a simple combination of materials and any compound that can result from such a combination.

[0015] As used herein, "molecular weight" or "molecular weight" refers to weight average molecular weight, unless otherwise specified. Molecular weight is measured using gel permeation chromatography ("GPC"), an industry standard method.

[0016] When amount ranges are listed, they should be understood to refer to the total amount of that ingredient in the composition, or, if more than one ingredient range falls within a definition, the total amount of all ingredients fitting that definition in the composition. For example, if a composition contains 1% to 5% fatty alcohols, a composition containing 2% stearyl alcohol and 1% cetyl alcohol, and no other fatty alcohols, would fall within this range.

[0017] The amount of each specific ingredient, or mixtures thereof, described below can represent up to (or equal to) 100% of the total amount of one or more ingredients in the hair care composition.

[0018] As used herein, "personal care compositions" include products such as shampoos, shower gels, liquid hand washes, hair dyes, facial cleansers, and other surfactant-based liquid compositions.

[0019] As used herein, the terms "include," "includes," and "including" are meant to be open-ended and are understood to mean "comprise," "comprises," and "comprising," respectively.

[0020] All percentages, parts and ratios are by weight of the total composition of the present invention unless otherwise specified. All such weights, as they pertain to listed ingredients, are based on the active level and, therefore, do not include carriers or by-products that may be included in commercially available materials.

[0021] Unless otherwise stated, all component or composition concentrations are in terms of the active portion of that component or composition and are exclusive of impurities, such as residual solvents or by-products, that may be present in commercial sources of such component or composition.

[0022] It should be understood that every maximum numerical limitation given throughout this specification includes every lower numerical limitation, as if such lower numerical limitations were expressly written herein. Every minimum numerical limitation given throughout this specification includes every higher numerical limitation, as if such higher numerical limitations were expressly written herein. Every numerical range given throughout this specification includes every narrower numerical range that falls within such broader numerical range, as if such narrower numerical ranges were all expressly written herein.

[0023] Surfactant-soluble agents A surfactant-soluble agent is a material that undergoes molecular solubilization by a surfactant-water mixture and resides in surfactant micelles. These materials include antibacterial and antifungal agents such as octopirox, triclosan, climbazole, ciclopirox, rilopirox, MEA-hydroxyoctyloxypyridinone, strobilurins, azoxystrobin, 1,10-phenanthroline, ketoconazole, benzimidazole, benzothiazole, bifonazole, butaconazole nitrate, climbazole, clotrimazole, cloconazole, eberconazole, econazole, elubiol, fenticonazole, fluconazole, flutimazole, isoconazole, ketoconazole, lanoconazole, metronidazole, miconazole, neticonazole, omoconazole, oxiconazole nitrate, sertaconazole, sulconazole nitrate, tioconazole, thiazoles, and mixtures thereof, or the azole antibacterial agent is a triazole selected from the group consisting of terconazole, itraconazole, and mixtures thereof.

[0024] Surfactant-soluble agents can be non-polar solids or oils that are molecularly solubilized by the surfactant-water mixture and reside in surfactant micelles. These include, but are not limited to, hydrocarbon materials such as mineral oil, soybean oil, and polyols.

[0025] The surfactant-soluble agent may also be a functionalized hydrocarbon solid or oil that can be molecularly solubilized by the surfactant-water mixture and reside in the surfactant micelles, including, but not limited to, menthol and other flavors.

[0026] The surfactant-soluble agent may be present in an amount of about 0.01% to 10%, about 0.1% to about 7%, about 0.20% to 5%, about 0.20% to about 3%, about 0.30% to about 3%, and about 0.30% to about 1%.

[0027] A. Detersive surfactants The personal care composition may comprise greater than about 8% by weight of a surfactant system that provides cleaning performance to the composition, or greater than 12% by weight of a surfactant system that provides cleaning performance to the composition. The surfactant system comprises an anionic surfactant, and / or a combination of anionic surfactants, and / or a combination of anionic surfactants with a co-surfactant selected from the group consisting of amphoteric, zwitterionic, nonionic, and mixtures thereof. Various examples and descriptions of detersive surfactants are described in U.S. Pat. No. 8,440,605, U.S. Patent Application Publication Nos. 2009 / 155383, and 2009 / 0221463, which are incorporated herein by reference in their entireties.

[0028] Suitable anionic surfactants for use in the present composition are alkyl and alkyl ether sulfates.Other suitable anionic surfactants are water-soluble salts of organic sulfuric acid reaction products.Still other suitable anionic surfactants are reaction products of fatty acids esterified with isethionic acid and neutralized with sodium hydroxide.Other similar anionic surfactants are described in U.S. Patent Nos. 2,486,921, 2,486,922, and 2,396,278, which are incorporated herein by reference in their entirety.

[0029] The hair care composition may comprise from about 10% to about 25%, from about 11% to about 20%, from about 12% to about 20%, and / or from about 12% to about 18% by weight of one or more surfactants.

[0030] Exemplary anionic surfactants for use in hair care compositions include ammonium lauryl sulfate, ammonium laureth sulfate, ammonium C10-15 pareth sulfate, ammonium C10-15 alkyl sulfate, ammonium C11-15 alkyl sulfate, ammonium decyl sulfate, ammonium deceth sulfate, ammonium undecyl sulfate, ammonium undeceth sulfate, triethylamine lauryl sulfate, triethylamine laureth sulfate, triethanolamine lauryl sulfate, triethanolamine laureth sulfate, monoethanolamine lauryl sulfate, monoethanolamine laureth sulfate, diethanolamine lauryl sulfate, diethanolamine laureth sulfate, lauric acid monoglyceride sodium sulfate, sodium lauryl sulfate, sodium laureth sulfate, sodium C10-15 pareth sulfate, sodium C10-15 alkyl sulfate, sodium C11-15 alkyl sulfate, sodium decyl sulfate, sodium deceth sulfate, Examples of anionic surfactants include sodium undecyl sulfate, sodium undeceth sulfate, potassium lauryl sulfate, potassium laureth sulfate, C10-15 potassium pareth sulfate, C10-15 potassium alkyl sulfate, C11-15 potassium alkyl sulfate, potassium decyl sulfate, potassium deceth sulfate, potassium undecyl sulfate, potassium undeceth sulfate, sodium lauryl sarcosinate, sodium lauroyl sarcosinate, lauryl sarcosine, cocoyl sarcosine, ammonium cocoyl sulfate, ammonium lauroyl sulfate, sodium cocoyl sulfate, sodium lauroyl sulfate, potassium cocoyl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, triethanolamine lauryl sulfate, monoethanolamine cocoyl sulfate, monoethanolamine lauryl sulfate, sodium tridecylbenzenesulfonate, sodium dodecylbenzenesulfonate, sodium cocoyl isethionate, and combinations thereof. The anionic surfactant may be sodium lauryl sulfate or sodium laureth sulfate.

[0031] The compositions of the present invention may contain from about 8% to about 17% by weight, from about 8% to about 13% by weight, and from about 10% to about 13% by weight of anionic surfactant.

[0032] The compositions of the present invention also comprise a) RO(CHCHR0) y SO3M, b) CH3(CH2) z CHR2CH2O(CH2CHR3O) y SO3M, and c) Mixtures of these (Wherein R1 is CH3(CH2) 10 wherein R2 represents H or a hydrocarbon radical containing 1 to 4 carbon atoms such that the sum of the carbon atoms in z and R2 is 8; R3 is H or CH3; y is 0 to 7, and when y is not zero (0), the average value of y is about 1; and M is a monovalent or divalent positively charged cation.

[0033] Suitable anionic alkyl sulfate and alkyl ether sulfate surfactants include, but are not limited to, those having branched alkyl chains synthesized from C8 to C18 branched alcohols, which may be selected from the group consisting of Guerbet alcohols, aldol condensation derived alcohols, oxo alcohols, FT oxo alcohols, and mixtures thereof. Non-limiting examples of 2-alkyl branched alcohols include 2-methyl-1-undecanol, 2-ethyl-1-decanol, 2-propyl-1-nonanol, 2-butyl-1-octanol, 2-methyl-1-dodecanol, 2-ethyl-1-undecanol, 2-propyl-1-decanol, 2-butyl-1-nonanol, 2-pentyl-1-octanol, 2-pentyl-1-heptanol, and surfactants sold under the trade names LIAL® (Sasol), ISALCHEM (Sasol), and NEODOL® (Shell), as well as oxo alcohols such as those sold under the trade name ISOFOL® (Sasol), 2-propyl-1-butanol, 2-butyl-1-octanol, 2-butyl-1-decanol, 2-pentyl-1-nonanol, 2-hexyl-1-octanol, 2-hexyl-1-decanol, and Guerbet and aldol condensation derived alcohols such as those sold under the trade name ISOFOL® (Sasol), or as alcohol ethoxylates and alkoxylates under the trade names LUTENSOL XP® (BASF) and LUTENSOL XL® (BASF).

[0034] Anionic alkyl sulfates and alkyl ether sulfates may also include those synthesized from C8 to C18 branched alcohols derived from butylene or propylene, sold under the trade names EXXAL™ (Exxon) and Marlipal® (Sasol). This includes the subclass of anionic surfactants, sodium trideceth-n sulfate (STnS), where n is from about 0.5 to about 3.5. Exemplary surfactants of this subclass are sodium trideceth-2 sulfate and sodium trideceth-3 sulfate. The compositions of the present invention may also include sodium tridecyl sulfate.

[0035] The surfactant system can include one or more amino acid-based anionic surfactants.Non-limiting examples of amino acid-based anionic surfactants can include sodium, ammonium, or potassium salts of acylglycinate; sodium, ammonium, or potassium salts of acylsarcosinate; sodium, ammonium, or potassium salts of acylglutamate; sodium, ammonium, or potassium salts of acylalaninate; and combinations thereof.

[0036] The amino acid-based anionic surfactant can be a glutamate, e.g., an acylglutamate. The composition can contain an acylglutamate concentration of about 2% to about 22% by weight, about 3% to about 19% by weight, 4% to about 17% by weight, and / or about 5% to about 15% by weight.

[0037] Non-limiting examples of acyl glutamates include sodium cocoyl glutamate, disodium cocoyl glutamate, ammonium cocoyl glutamate, diammonium cocoyl glutamate, sodium lauroyl glutamate, disodium lauroyl glutamate, sodium cocoyl hydrolyzed wheat protein glutamate, disodium cocoyl hydrolyzed wheat protein glutamate, potassium cocoyl glutamate, dipotassium cocoyl glutamate, potassium lauroyl glutamate, dipotassium lauroyl glutamate, potassium cocoyl hydrolyzed wheat protein glutamate, dipotassium cocoyl hydrolyzed wheat protein glutamate, sodium capryloyl glutamate, disodium capryloyl glutamate, potassium capryloyl glutamate, dipotassium capryloyl glutamate, sodium undecylenoyl glutamate, disodium undecylenoyl glutamate, potassium undecylenoyl glutamate, undecylenoyl The glutamate may be selected from the group consisting of dipotassium glutamate, hydrogenated tallow glutamate disodium, sodium stearoyl glutamate, disodium stearoyl glutamate, potassium stearoyl glutamate, dipotassium stearoyl glutamate, sodium myristoyl glutamate, disodium myristoyl glutamate, potassium myristoyl glutamate, dipotassium myristoyl glutamate, cocoyl / hydrogenated tallow glutamate, cocoyl / palmoyl / sunfloweroyl sodium glutamate, hydrogenated tallow oil sodium glutamate, sodium olivoyl glutamate, olivoyl glutamate disodium, palmoyl glutamate, disodium palmoyl glutamate, TEA-cocoyl glutamate, TEA-hydrogenated tallow oil glutamate, TEA-lauroyl glutamate, and mixtures thereof.

[0038] The amino acid-based anionic surfactant may be an alaninate, such as an acyl alaninate. Non-limiting examples of acyl alaninates include sodium cocoyl alaninate, sodium lauroyl alaninate, sodium N-dodecanoyl-l-alaninate, and combinations thereof. The composition may have an acyl alaninate concentration of about 2% to about 20% by weight, about 7% to about 15% by weight, and / or about 8% to about 12% by weight.

[0039] The amino acid based anionic surfactants can be sulfosuccinates, anionic alkyl and alkyl ether sulfosuccinates, and / or dialkyl and dialkyl ether sulfosuccinates, and mixtures thereof. Non-limiting examples of sulfosuccinate surfactants include disodium N-octadecyl sulfosuccinate, disodium lauryl sulfosuccinate, diammonium lauryl sulfosuccinate, sodium lauryl sulfosuccinate, disodium laureth sulfosuccinate, bistridecyl sulfosuccinate, tetrasodium N-(1,2-dicarboxyethyl)-N-octadecyl sulfosuccinate, diamyl ester of sodium sulfosuccinate, dihexyl ester of sodium sulfosuccinate, dioctyl ester of sodium sulfosuccinate, sodium bistridecyl sulfosuccinate, dioctyl sodium sulfosuccinate, dihexyl sodium sulfosuccinate, dicyclohexyl sodium sulfosuccinate, diamyl sodium sulfosuccinate, diisobutyl sodium sulfosuccinate, linear bis(tridecyl) sulfosuccinate, and combinations thereof. The dialkyl and dialkyl ether sulfosuccinates may be C6-15 linear or branched dialkyl or dialkyl ether sulfosuccinates. The alkyl moieties may be symmetric (i.e., the same alkyl moieties) or asymmetric (i.e., different alkyl moieties).Non-limiting examples of sarcosinates include sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, TEA-cocoyl sarcosinate, ammonium cocoyl sarcosinate, ammonium lauroyl sarcosinate, dimer dilinoleyl bis-lauroyl glutamate / lauroyl sarcosinate, disodium lauroyl sarcosinate lauroamphodiacetate, sarcosinate), isopropyl lauroyl sarcosinate, potassium cocoyl sarcosinate, potassium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, sodium oleoyl sarcosinate, sodium palmitoyl sarcosinate, TEA-cocoyl sarcosinate, TEA-lauroyl sarcosinate, TEA-oleoyl sarcosinate, TEA-palm kernel sarcosinate, and combinations thereof.

[0040] The amino acid-based anionic surfactant can be a glycinate, such as an acyl glycinate. Non-limiting examples of acyl glycinates include sodium cocoyl glycinate, sodium lauroyl glycinate, and combinations thereof.

[0041] The composition may contain an additional anionic surfactant selected from the group consisting of sulfosuccinates, isethionates, sulfonates, sulfoacetates, glucose carboxylates, alkyl ether carboxylates, acyltaurates, and mixtures thereof.

[0042] Suitable isethionate surfactants can include the reaction product of a fatty acid esterified with isethionic acid and neutralized with sodium hydroxide. Suitable fatty acids for isethionate surfactants can be derived from coconut oil or palm kernel oil, such as amides of methyl tauride. Non-limiting examples of isethionates can be selected from the group consisting of sodium lauroyl methyl isethionate, sodium cocoyl isethionate, ammonium cocoyl isethionate, hydrogenated sodium cocoyl methyl isethionate, sodium lauroyl isethionate, sodium cocoyl methyl isethionate, sodium myristoyl isethionate, sodium oleoyl isethionate, sodium oleyl methyl isethionate, sodium palm kernel oil isethionate, sodium stearoyl methyl isethionate, and mixtures thereof.

[0043] Non-limiting examples of sulfonates can include alpha olefin sulfonates, linear alkyl benzene sulfonates, sodium lauryl glucoside hydroxypropyl sulfonate, and combinations thereof.

[0044] Non-limiting examples of sulfoacetates include sodium lauryl sulfoacetate, ammonium lauryl sulfoacetate, and combinations thereof.

[0045] Non-limiting examples of glucose carboxylates include sodium lauryl glucoside carboxylate, sodium cocoyl glucoside carboxylate, and combinations thereof.

[0046] Non-limiting examples of alkyl ether carboxylates include sodium laureth-4 carboxylate, laureth-5 carboxylate, laureth-13 carboxylate, sodium C12-13 pareth-8 carboxylate, sodium C12-15 pareth-8 carboxylate, and combinations thereof.

[0047] Non-limiting examples of acyltaurates include sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium methyl oleoyl taurate, and combinations thereof.

[0048] The surfactant system may further comprise one or more amphoteric surfactants, which may be selected from the group consisting of betaines, sultaines, hydroxysultanones, amphohydroxypropylsulfonates, alkyl amphoactates, alkyl amphodiacetates, and combinations thereof.

[0049] Examples of betaine amphoteric surfactants, which are often used as cosurfactants, include cocodimethylcarboxymethyl betaine, cocoamidopropyl betaine (CAPB), cocobetaine, laurylamidopropyl betaine (LAPB), oleyl betaine, lauryldimethylcarboxymethyl betaine, lauryldimethyl α-carboxyethyl betaine, cetyldimethylcarboxymethyl betaine, lauryl bis-(2-hydroxyethyl)carboxymethyl betaine, stearyl bis-(2-hydroxypropyl)carboxymethyl betaine, oleyldimethyl γ-carboxypropyl betaine, lauryl bis-(2-hydroxypropyl)α-carboxyethyl betaine, and mixtures thereof. Examples of sulfobetaines include cocodimethylsulfopropyl betaine, stearyl dimethylsulfopropyl betaine, lauryldimethylsulfoethyl betaine, lauryl bis-(2-hydroxyethyl)sulfopropyl betaine, and mixtures thereof.

[0050] Non-limiting examples of alkylamphoacetates include sodium cocoylamphoacetate, sodium lauroylamphoacetate, and combinations thereof.

[0051] The surfactant system may further comprise one or more non-ionic surfactants, which may be selected from the group consisting of alkyl polyglucosides, alkyl glycosides, acyl glucamides, and mixtures thereof. Non-limiting examples of alkyl glucosides include decyl glucoside, cocoyl glucoside, lauroyl glucoside, and combinations thereof.

[0052] Non-limiting examples of acyl glucamides include lauroyl / myristoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocoyl methyl glucamide, and combinations thereof.

[0053] The hair care composition may contain a co-surfactant. The co-surfactant may be selected from the group consisting of amphoteric surfactants, zwitterionic surfactants, nonionic surfactants, and mixtures thereof. The co-surfactant may include, but is not limited to, lauramidopropyl betaine, cocoamidopropyl betaine, lauryl hydroxysultaine, sodium lauroamphoacetate, disodium cocoamphodiacetate, cocamide monoethanolamide, and mixtures thereof.

[0054] Suitable amphoteric or zwitterionic surfactants for use in the hair care compositions herein include those known for use in shampoos or other hair care cleansers. Non-limiting examples of suitable zwitterionic or amphoteric surfactants are described in U.S. Patent Nos. 5,104,646 and 5,106,609, which are incorporated herein by reference in their entireties.

[0055] Suitable amphoteric co-surfactants for use in the compositions include surfactants described as derivatives of aliphatic secondary and tertiary amines, where the aliphatic radicals can be straight or branched, and where one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one contains an anionic group such as carboxy, sulfonate, sulfate, phosphate, or phosphonate. Suitable amphoteric surfactants include sodium cocaminopropionate, sodium cocaminodipropionate, sodium cocoamphoacetate, sodium cocoamphodiacetate, sodium cocoamphohydroxypropylsulfonate, sodium cocoamphopropionate, sodium cornamphopropionate, sodium lauraminopropionate, sodium lauroamphoacetate, sodium lauroamphodiacetate, sodium lauroamphohydroxypropylsulfonate, sodium lauroamphopropionate, sodium cornamphopropionate, sodium lauriminodipropionate, ammonium cocaminopropionate, ammonium cocaminodipropionate, ammonium cocoamphoacetate, ammonium cocoamphodiacetate, ammonium cocoamphohydroxypropylsulfonate, ammonium cocoamphopropionate, ammonium cornamphopropionate, ammonium lauraminopropionate, lauroamphoacetic acid Ammonium lauroamphodiacetate, ammonium lauroamphohydroxypropylsulfonate, ammonium lauroamphopropionate, ammonium cornamphopropionate, ammonium lauriminodipropionate, triethanolamine cocaminopropionate, triethanolamine cocaminodipropionate, triethanolamine cocoamphoacetate, triethanolamine cocoamphohydroxypropylsulfonate, triethanolamine cocoamphopropionate, triethanolamine cornamphopropionate, triethanolamine lauraminopropionate, triethanolamine lauroamphoacetate, triethanolamine lauroamphohydroxypropylsulfonate, triethanolamine lauroamphopropionate, triethanolamine cornamphopropionate, triethanolamine lauriminodipropionate, cocoamphodipropionic acid, disodium caproamphodiacetateDisodium caproamphodipropionate, disodium capryloamphodiacetate, disodium capryloamphodipropionate, disodium cocoamphocarboxyethylhydroxypropylsulfonate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, disodium dicarboxyethylcocopropylenediamine, disodium laureth-5 carboxyamphodiacetate, disodium lauriminodipropionate, disodium lauroamphodiacetate, disodium lauroamphodipropionate, disodium oleoamphodipropionate, disodium PPG-2-isodecyl-7 carboxyamphodiacetate, lauraminopropionic acid, lauroamphodipropionic acid, laurylaminopropylglycine, lauryldiethylenediaminoglycine, and mixtures thereof.

[0056] The composition may also include zwitterionic co-surfactants, which are derivatives of aliphatic quaternary ammonium, phosphonium, and sulfonium compounds, where the aliphatic radicals may be straight or branched chain, and one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one contains an anionic group such as carboxy, sulfonate, sulfate, phosphate, or phosphonate. The zwitterionic surfactant may be selected from the group consisting of cocamidoethyl betaine, cocamidopropylamine oxide, cocamidopropyl betaine, cocamidopropyl dimethylaminohydroxypropyl hydrolyzed collagen, cocamidopropyldimonium hydroxypropyl hydrolyzed collagen, cocamidopropyl hydroxysultaine, cocobetaineamidoamphopropionate, coco-betaine, coco-hydroxysultaine, coco / oleamidopropyl betaine, coco-sultaine, lauramidopropyl betaine, lauryl betaine, lauryl hydroxysultaine, lauryl sultaine, and mixtures thereof.

[0057] Nonionic surfactants suitable for use in the present invention include those described in McCutcheon's Detergents and Emulsifiers, North American edition (1986), Allured Publishing Corp., and McCutcheon's Functional Materials, North American edition (1992). Nonionic surfactants suitable for use in the personal care compositions of the present invention include, but are not limited to, polyoxyethylenated alkylphenols, polyoxyethylenated alcohols, polyoxyethylenated polypropylene glycols, glyceryl esters of alkanoic acids, polyglyceryl esters of alkanoic acids, propylene glycol esters of alkanoic acids, sorbitol esters of alkanoic acids, polyoxyethylenated sorbitol esters of alkanoic acids, polyoxyethylene glycol esters of alkanoic acids, polyoxyethylenated alkanoic acids, alkanolamides, N-alkylpyrrolidones, alkyl glycosides, alkyl polyglucosides, alkyl amine oxides, and polyoxyethylenated silicones. Suitable nonionic surfactants include nonionic triblock copolymers composed of polyoxypropylene and polyoxyethylene. A non-limiting example is Poloxamer 184, a nonionic triblock copolymer composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene.

[0058] The co-surfactant can be a nonionic surfactant selected from the group of alkanolamides including cocamide, cocamide methyl MEA, cocamide DEA, cocamide MEA, cocamide MIPA, lauramide DEA, lauramide MEA, lauramide MIPA, myristamide DEA, myristamide MEA, PEG-20 cocamide MEA, PEG-2 cocamide, PEG-3 cocamide, PEG-4 cocamide, PEG-5 cocamide, PEG-6 cocamide, PEG-7 cocamide, PEG-3 lauramide, PEG-5 lauramide, PEG-3 oleamide, PPG-2 cocamide, PPG-2 hydroxyethyl cocamide, PPG-2 hydroxyethyl isostearamide, and mixtures thereof.

[0059] Representative polyoxyethylenated alcohols include alkyl chains ranging from C9 to C16 and having from about 1 to about 110 alkoxy groups, including, but not limited to, laureth-3, laureth-23, ceteth-10, steareth-10, steareth-100, beheneth-10, and those commercially available from Shell Chemicals (Houston, Texas) under the trade names Neodol® 91, Neodol® 23, Neodol® 25, Neodol® 45, Neodol® 135, Neodol® 67, Neodol® PC100, Neodol® PC200, Neodol® PC600, and mixtures thereof.

[0060] Also commercially available are polyoxyethylene aliphatic ethers available from Uniqema (Wilmington, Delaware) under the Brij® trade name, including, but not limited to, Brij® 30, Brij® 35, Brij® 52, Brij® 56, Brij® 58, Brij® 72, Brij® 76, Brij® 78, Brij® 93, Brij® 97, Brij® 98, Brij® 721, and mixtures thereof.

[0061] Suitable alkyl glycosides and alkyl polyglucosides can be represented by the formula (S)nOR, where S is a sugar moiety such as glucose, fructose, mannose, galactose, etc.; n is an integer from about 1 to about 1000; and R is a C8-C30 alkyl group. Examples of long-chain alcohols from which the alkyl group can be derived include decyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, and the like. Examples of these surfactants include alkyl polyglucosides, where S is a glucose moiety, R is a C8-20 alkyl group, and n is an integer from about 1 to about 9. Commercially available examples of these surfactants include decyl polyglucosides and lauryl polyglucosides, available from Cognis (Ambler, Pa.) under the trade names APG® 325CS, APG® 600CS, and APG® 625CS. Also useful herein are sucrose ester surfactants such as sucrose cocoate and sucrose laurate, as well as alkyl polyglucosides available from Dow Chemical Company (Houston, Tx) under the trade names Triton™ BG-10 and Triton™ CG-110.

[0062] Other nonionic surfactants suitable for use in the present invention are glyceryl esters and polyglyceryl esters, including, but not limited to, glyceryl monoesters, e.g., glyceryl oleate, glyceryl monostearate, glyceryl monopalmitate, glyceryl monobehenate, and mixtures thereof, of C12-22 saturated, unsaturated, and branched chain fatty acids, and polyglyceryl esters of C12-22 saturated, unsaturated, and branched chain fatty acids, e.g., polyglyceryl-4 isostearate, polyglyceryl-3 oleate, polyglyceryl-2-sesquioleate, triglyceryl diisostearate, diglyceryl monooleate, tetraglyceryl monooleate, and mixtures thereof.

[0063] Also useful herein as nonionic surfactants are sorbitan esters. Sorbitan esters of C12-22 saturated, unsaturated, and branched-chain fatty acids are useful herein. These sorbitan esters typically comprise a mixture of esters, such as monoesters, diesters, and triesters. Representative examples of suitable sorbitan esters include sorbitan monolaurate (SPAN® 20), sorbitan monopalmitate (SPAN® 40), sorbitan monostearate (SPAN® 60), sorbitan tristearate (SPAN® 65), sorbitan monooleate (SPAN® 80), sorbitan trioleate (SPAN® 85), and sorbitan isostearate.

[0064] Also suitable for use herein are alkoxylated derivatives of sorbitan esters, including, but not limited to, polyoxyethylene (20) sorbitan monolaurate (Tween® 20), polyoxyethylene (20) sorbitan monopalmitate (Tween® 40), polyoxyethylene (20) sorbitan monostearate (Tween® 60), polyoxyethylene (20) sorbitan monooleate (Tween® 80), polyoxyethylene (4) sorbitan monolaurate (Tween® 21), polyoxyethylene (4) sorbitan monostearate (Tween® 61), polyoxyethylene (5) sorbitan monooleate (Tween® 81), and mixtures thereof, all available from Uniqema.

[0065] Also suitable for use herein are alkylphenol ethoxylates, including, but not limited to, nonylphenol ethoxylates (Tergitol™ NP-4, NP-6, NP-7, NP-8, NP-9, NP-10, NP-11, NP-12, NP-13, NP-15, NP-30, NP-40, NP-50, NP-55, NP-70, available from Dow Chemical Company, Houston, Tex.) and octylphenol ethoxylates (Triton™ X-15, X-35, X-45, X-114, X-100, X-102, X-165, X-305, X-405, X-705, available from Dow Chemical Company, Houston, Tex.).

[0066] Also suitable for use herein are tertiary alkyl amine oxides, including lauramine oxide and cocamine oxide.

[0067] Non-limiting examples of other anionic, zwitterionic, amphoteric, and nonionic additional surfactants suitable for use in the hair care compositions are described in McCutcheon's, Emulsifiers and Detergents, 1989 Annual (published by MC Publishing Co.), and U.S. Pat. Nos. 3,929,678, 2,658,072, 2,438,091, and 2,528,378, which are incorporated herein by reference in their entireties.

[0068] The hair care composition may have a concentration of surfactant to surfactant-soluble active of 15:1 by weight. The hair care composition may have a concentration of surfactant to surfactant-soluble active of 10:1 by weight. The hair care composition may have a concentration of surfactant to surfactant-soluble active of 8:1 by weight.

[0069] B. Cationic polymers The hair care composition may include a cationic polymer. These cationic polymers may include at least one of: (a) cationic guar polymers, (b) cationic non-guar galactomannan polymers, (c) cationic tapioca polymers, (d) cationic copolymers of acrylamide monomers and cationic monomers, and / or (e) synthetic non-crosslinked cationic polymers that may or may not form lyotropic liquid crystals when combined with a detersive surfactant; and (f) cationic cellulose polymers. Additionally, the cationic polymer may be a mixture of cationic polymers.

[0070] Hair care compositions may contain cationic guar polymers, which are cationically substituted galactomannan (guar) gum derivatives. The guar gum used to prepare these guar gum derivatives is typically obtained as a naturally occurring material from the seeds of the guar plant. The guar molecule itself is a regularly branched linear mannan in which single-membered galactose units alternate with mannose units. The mannose units are linked to each other by β(1-4) glycosidic bonds. The galactose branches arise from α(1-6) linkages. Cationic derivatives of guar gum are obtained by the reaction between the hydroxyl groups of polygalactomannans and reactive quaternary ammonium compounds. The degree of substitution of cationic groups on the guar structure must be sufficient to provide the required cationic charge density described above.

[0071] The cationic guar polymer can be formed from a quaternary ammonium compound. The quaternary ammonium compound for forming the cationic guar polymer can conform to the general formula 1:

[0072] [ka] In the formula, R 3 , R 4 , and R 5 is a methyl or ethyl group, and R 6 is an epoxyalkyl group of general formula 2,

[0073] [ka] Or R 6 is a halohydrin group of general formula 3,

[0074] [ka] In the formula, R 7 is a C1-C3 alkylene, X is chlorine or bromine, and Z is an anion such as Cl-, Br-, I-, or HSO4-.

[0075] The cationic guar polymer may conform to the general formula 4:

[0076] [ka] In the formula, R 8 is guar gum, R 4 , R 5 , R 6 , and R 7 is as defined above and Z is a halogen. The cationic guar polymer can conform to formula 5.

[0077] [ka]

[0078] Suitable cationic guar polymers include cationic guar gum derivatives such as guar hydroxypropyltrimonium chloride. The cationic guar polymer can be guar hydroxypropyltrimonium chloride. Specific examples of guar hydroxypropyltrimonium chloride include the Jaguar® series available from Solvay, such as Jaguar® C-500 available from Solvay. Jaguar® C-500 has a charge density of 0.8 meq / g and a molecular weight of 500,000 g / mol. Another suitable guar hydroxypropyltrimonium chloride is guar hydroxypropyltrimonium chloride, which has a charge density of about 1.3 meq / g and a molecular weight of about 500,000 g / mol and is available from Solvay as Jaguar® Optima. Other suitable guar hydroxypropyltrimonium chlorides are those available from Solvay as Jaguar® Excel, with a charge density of about 0.7 meq / g and a molecular weight of about 1,500,000 g / mol; those available from ASI as guar hydroxypropyltrimonium chloride, with a charge density of about 1.1 meq / g and a molecular weight of about 500,000 g / mol; and those available from ASI as guar hydroxypropyltrimonium chloride, with a charge density of about 1.5 meq / g and a molecular weight of about 500,000 g / mol.

[0079] Other suitable guar hydroxypropyltrimonium chlorides are Hi-Care 1000, which has a charge density of about 0.7 meq / g and a molecular weight of about 600,000 g / mol and is available from Solvay; N-Hance 3269 and N-Hance 3270, which have a charge density of about 0.7 meq / g and a molecular weight of about 425,000 g / mol and are available from ASI; and N-Hance 3196, which has a charge density of about 0.8 meq / g and a molecular weight of about 1,100,000 g / mol and is available from ASI. AquaCat CG518, which has a charge density of about 0.9 meq / g and a molecular weight of about 50,000 g / mol and is available from ASI. BF-13, a borate-free guar having a charge density of about 1.1 meq / g and a molecular weight of about 800,000, and BF-17, a borate-free guar having a charge density of about 1.5 meq / g and a molecular weight of about 800,000, are both available from ASI.

[0080] The hair care compositions of the present invention may comprise a galactomannan polymer derivative having a mannose-to-galactose ratio of greater than 2:1 on a monomer-to-monomer basis, the galactomannan polymer derivative being selected from the group consisting of cationic galactomannan polymer derivatives and amphoteric galactomannan polymer derivatives having a net positive charge. As used herein, the term "cationic galactomannan" refers to a galactomannan polymer to which cationic groups have been added. The term "amphoteric galactomannan" refers to a galactomannan polymer to which cationic and anionic groups have been added such that the polymer has a net positive charge.

[0081] Galactomannan polymers are present in the endosperm of legume seeds. Galactomannan polymers are composed of a combination of mannose and galactose monomers. Galactomannan molecules are linear mannans in which single-membered galactose units branch at regular intervals on specific mannose units. The mannose units are linked to each other by β(1-4) glycosidic bonds. Galactose branches occur via α(1-6) linkages. The ratio of mannose to galactose monomers varies depending on the plant species and is also influenced by climate. The non-guar galactomannan polymer derivatives of the present invention have a mannose-to-galactose ratio of greater than 2:1 on a monomer-to-monomer basis. A suitable mannose-to-galactose ratio may be greater than about 3:1, and a suitable mannose-to-galactose ratio may be greater than about 4:1. Analysis of the mannose-to-galactose ratio is well known in the art and is typically based on measuring galactose content.

[0082] Gums used in the preparation of non-guar galactomannan polymer derivatives are typically obtained as natural materials such as plant seeds or beans. Examples of various non-guar galactomannan polymers include, but are not limited to, tara gum (3 parts mannose / 1 part galactose), locust bean or carob (4 parts mannose / 1 part galactose), and cassia gum (5 parts mannose / 1 part galactose).

[0083] The non-guar galactomannan polymer derivatives can have a molecular weight of from about 1,000 to about 10,000,000, and / or from about 5,000 to about 3,000,000.

[0084] The hair care compositions of the present invention can further comprise a galactomannan polymer derivative having a cationic charge density of about 0.5 meq / g to about 7 meq / g. The galactomannan polymer derivative can have a cationic charge density of about 1 meq / g to about 5 meq / g. The degree of substitution of cationic groups onto the galactomannan structure must be sufficient to provide the required cationic charge density.

[0085] The galactomannan polymer derivative may be a cationic derivative of a non-guar galactomannan polymer, obtained by reacting the hydroxyl groups of the polygalactomannan polymer with a reactive quaternary ammonium compound. Suitable quaternary ammonium compounds for use in forming the cationic galactomannan polymer derivative include those conforming to the general formulas 1-5 defined above.

[0086] The cationic non-guar galactomannan polymer derivatives formed from the above reagents are represented by general formula 6:

[0087] [ka] wherein R is a gum. The cationic galactomannan derivative can be gum hydroxypropyltrimethylammonium chloride, which can be more specifically represented by the following general formula 7:

[0088] [ka]

[0089] Alternatively, the galactomannan polymer derivative may be an amphoteric galactomannan polymer derivative having a net positive charge, which is obtained when the cationic galactomannan polymer derivative further comprises an anionic group.

[0090] The cationic non-guar galactomannan can have a mannose to galactose ratio of greater than about 4:1, a molecular weight of about 1,000 g / mol to about 10,000,000 g / mol, and / or about 50,000 g / mol to about 1,000,000 g / mol, and / or about 100,000 g / mol to about 900,000 g / mol, and / or about 150,000 g / mol to about 400,000 g / mol, and a cationic charge density of about 1 meq / g to about 5 meq / g, and / or 2 meq / g to about 4 meq / g, and can be obtained from the cassia plant.

[0091] The hair care composition can comprise a water-soluble cationically modified starch polymer.As used herein, the term "cationically modified starch" refers to starch to which cationic groups are added before the starch is decomposed into smaller molecular weights, or to starch to which cationic groups are added after the starch is modified to achieve a desired molecular weight.The definition of the term "cationically modified starch" also includes amphoterically modified starch.The term "amphoterically modified starch" refers to starch hydrolysate to which cationic and anionic groups are added.

[0092] The cationically modified starch polymers disclosed in the present invention have a percentage of bound nitrogen of from about 0.5% to about 4%.

[0093] The cationically modified starch polymers used in the hair care compositions can have a molecular weight of from about 850,000 g / mol to about 1,500,000 g / mol, and / or from about 900,000 g / mol to about 1,500,000 g / mol.

[0094] The hair care composition may include a cationically modified starch polymer having a charge density of about 0.2 meq / g to about 5 meq / g and / or about 0.2 meq / g to about 2 meq / g. Chemical modifications to achieve such charge densities include, but are not limited to, adding amino and / or ammonium groups to the starch molecule. Non-limiting examples of these ammonium groups include substituents such as hydroxypropyltrimonium chloride, trimethylhydroxypropylammonium chloride, dimethylstearylhydroxypropylammonium chloride, and dimethyldodecylhydroxypropylammonium chloride. See Solarek, DB, *Cationic Starches in Modified Starches: Properties and Uses*, *Wurzburg, OB, Ed., *CRC Press, Inc.* (Boca Raton, Fla.), 1986, pp. 113-125. Cationic groups may be added to the starch before it is degraded to smaller molecular weights, or the cationic groups may be added after such modification.

[0095] Cationically modified starch polymers typically have a degree of substitution of cationic groups of about 0.2 to about 2.5. As used herein, the "degree of substitution" of a cationically modified starch polymer is the average number of hydroxyl groups on each anhydroglucose unit that are derivatized with a substituent. Because each anhydroglucose unit has three possible hydroxyl groups available for substitution, the maximum possible degree of substitution is 3. The degree of substitution is expressed on a molar average basis as the number of moles of substituent per mole of anhydroglucose unit. The degree of substitution can be determined using proton nuclear magnetic resonance spectroscopy ("H NMR") techniques well known in the art. Suitable .sup.1H NMR methods include those described in "Observation on NMR Spectra of Starches in Dimethyl Sulfoxide, Iodine-Complexing, and Solvating in Water-Dimethyl Sulfoxide," Qin-Ji Peng and Arthur S. Perlin, Carbohydrate Research, 160 (1987), 57-72, and "An Approach to the Structural Analysis of Oligosaccharides by NMR Spectroscopy," J. Howard Bradbury and J. Grant Collins, Carbohydrate Research, 71 (1979), 15-25.

[0096] The source of starch before chemical modification can be selected from a variety of sources such as tubers, legumes, cereals, and grains, etc. Non-limiting examples of starch from this source can include corn starch, wheat starch, rice starch, waxy corn starch, oat starch, cassava starch, waxy barley, waxy rice starch, glutenous rice starch, glutenous rice starch, amioca, potato starch, tapioca starch, oat starch, sago starch, glutinous rice, or mixtures thereof.

[0097] The cationically modified starch polymers can be selected from degraded cationic corn starch, cationic tapioca, cationic potato starch, and mixtures thereof. Alternatively, the cationically modified starch polymers are cationic corn starch and cationic tapioca.

[0098] Starch may include one or more additional modifications before or after degradation to smaller molecular weights. For example, these modifications may include cross-linking, stabilization, phosphorylation, and hydrolysis. Stabilization may include alkylation and esterification.

[0099] The cationically modified starch polymers may be incorporated into the composition in the form of hydrolyzed starch (e.g., acid, enzymatic, or alkaline degradation), oxidized starch (e.g., peroxide, peracid, hypochlorite, alkali, or any other oxidizing agent), physically / mechanically degraded starch (e.g., by the thermal mechanical energy input of processing equipment), or combinations thereof.

[0100] The optimal form of starch is one that is easily solubilized in water to form a substantially transparent aqueous solution (approximately 80% transmittance at 600 nm). The transmittance of the composition is measured by ultraviolet-visible (UV / VIS) spectrophotometry, which measures the absorbance or transmittance of a sample of UV / VIS light using a Gretag Macbeth Colorimeter Color i 5 according to the relevant instructions. A light wavelength of 600 nm has been shown to be suitable for characterizing the transparency of cosmetic compositions.

[0101] The cationically modified starch suitable for use in hair care compositions can be obtained from known starch suppliers.Similarly, the nonionic modified starch suitable for use in hair care compositions can be further derivatized into cationically modified starch as known in the art.Other suitable modified starch starting materials can be quaternized as known in the art to produce the cationically modified starch polymer suitable for use in hair care compositions.

[0102] Starch Degradation Procedure: A starch slurry can be prepared by mixing granular starch in water. The temperature is raised to about 35°C. Aqueous potassium permanganate is then added at a concentration of about 50 ppm based on starch. The pH is raised to about 11.5 with sodium hydroxide, and the slurry is stirred thoroughly to prevent starch precipitation. Next, about a 30% solution of hydrogen peroxide diluted in water is added until the peroxide concentration based on starch is about 1%. Additional sodium hydroxide is then added to return the pH to about 11.5. The reaction is completed over a period of about 1 to about 20 hours. The mixture is then neutralized with dilute hydrochloric acid. The degraded starch is recovered by filtration, washed, and dried.

[0103] The hair care composition can include a cationic copolymer of an acrylamide monomer and a cationic monomer, the copolymer having a charge density of from about 1.0 meq / g to about 3.0 meq / g. The cationic copolymer can be a synthetic cationic copolymer of an acrylamide monomer and a cationic monomer.

[0104] The cationic copolymer may include: (i) an acrylamide monomer of formula AM:

[0105] [ka] In the formula, R 9 is H or C 1~4 alkyl, and R 10 and R11 are independently H, C 1~4 alkyl, CH2OCH3, CH2OCH2CH(CH3)2, and phenyl, or both of which are C 3~6 It is cycloalkyl. (ii) a cationic monomer conforming to the following formula C:

[0106] [ka] In the formula, k is 1; v, v', and v'' are each independently an integer of 1 to 6; w is 0 or an integer of 1 to 10; and X - is an anion.

[0107] The cationic monomer conforms to the formula CM, where k=1, v=3, and w=0, z=1, and X - is Cl - and the following structure can be formed:

[0108] [ka]

[0109] The above structure is sometimes referred to as a diquat. Alternatively, the cationic monomer can conform to the formula CM, where v and v" are each 3, v'=1, w=1, y=1, and X - is Cl - and so it becomes:

[0110] [ka]

[0111] The above structure is sometimes referred to as a triquat.

[0112] Suitable acrylamide monomers include, but are not limited to, either acrylamide or methacrylamide.

[0113] The cationic copolymer (b) can be AM:TRIQUAT, which is a copolymer of acrylamide and 1,3-propanediaminium, N-[2-[[[dimethyl[3-[(2-methyl-1-oxo-2-propenyl)amino]propyl]ammonio]acetyl]amino]ethyl]2-hydroxy-N,N,N',N',N'-pentamethyl-, trichloride. AM:TRIQUAT is also known as polyquaternium 76 (PQ76). AM:TRIQUAT can have a charge density of 1.6 meq / g and a molecular weight of 1,100,000 g / mol.

[0114] Further, the cationic copolymer may be of an acrylamide monomer and a cationic monomer, wherein the cationic monomer is selected from the group consisting of dimethylaminoethyl (meth)acrylate, dimethylaminopropyl (meth)acrylate, ditertiobutylaminoethyl (meth)acrylate, dimethylaminomethyl (meth)acrylamide, dimethylaminopropyl (meth)acrylamide; ethyleneimine, vinylamine, 2-vinylpyridine, 4-vinylpyridine; trimethylammonium ethyl (meth)acrylate chloride, trimethylammonium ethyl (meth)acrylate methyl sulfate, dimethylammonium ethyl (meth)acrylate benzyl chloride, 4-benzoylbenzyldimethylammonium ethyl acrylate chloride, trimethylammonium ethyl (meth)acrylamido chloride, trimethylammonium propyl (meth)acrylamido chloride, vinylbenzyl trimethylammonium chloride, diallyldimethylammonium chloride, and mixtures thereof.

[0115] The cationic copolymer can comprise a cationic monomer selected from the group consisting of cationic monomers including trimethylammonium ethyl (meth)acrylate chloride, trimethylammonium ethyl (meth)acrylate methyl sulfate, dimethylammonium ethyl (meth)acrylate benzyl chloride, 4-benzoylbenzyl dimethylammonium ethyl acrylate chloride, trimethylammonium ethyl (meth)acrylamide chloride, trimethylammonium propyl (meth)acrylamide chloride, vinylbenzyl trimethylammonium chloride, and mixtures thereof.

[0116] The cationic copolymer may be water-soluble. The cationic copolymer may be formed from (1) a copolymer of (meth)acrylamide and a cationic monomer based on (meth)acrylamide, and / or a hydrolytically stable cationic monomer, or (2) a terpolymer of (meth)acrylamide, a monomer based on a cationic (meth)acrylic acid ester, and a monomer based on (meth)acrylamide, and / or a hydrolytically stable cationic monomer. The monomer based on a cationic (meth)acrylic acid ester may be a cationized ester of (meth)acrylic acid containing a quaternized nitrogen atom. The cationized ester of (meth)acrylic acid containing a quaternized nitrogen atom may be a dialkylaminoalkyl (meth)acrylate quaternized at C1 to C3 in the alkyl and alkylene groups. Suitable cationized esters of (meth)acrylic acid containing quaternized nitrogen atoms can be selected from the group consisting of ammonium salts of dimethylaminomethyl (meth)acrylate, dimethylaminoethyl (meth)acrylate, dimethylaminopropyl (meth)acrylate, diethylaminomethyl (meth)acrylate, diethylaminoethyl (meth)acrylate, and diethylaminopropyl (meth)acrylate quaternized with methyl chloride. The cationized esters of (meth)acrylic acid containing quaternized nitrogen atoms can be dimethylaminoethyl acrylate (ADAME-Quat) quaternized with an alkyl halide, or with methyl chloride, benzyl chloride, or dimethyl sulfate. When the cationic monomer is based on (meth)acrylamide, it can be dialkylaminoalkyl (meth)acrylamide quaternized at C1 to C3 in the alkyl and alkylene groups, or dimethylaminopropyl acrylamide quaternized with an alkyl halide, methyl chloride, benzyl chloride, or dimethyl sulfate.

[0117] Suitable (meth)acrylamide-based cationic monomers include dialkylaminoalkyl(meth)acrylamides quaternized at C1 to C3 in the alkyl and alkylene groups. The (meth)acrylamide-based cationic monomer can be dimethylaminopropylacrylamide quaternized with an alkyl halide, in particular methyl chloride or benzyl chloride or dimethyl sulfate.

[0118] The cationic monomer may be a hydrolytically stable cationic monomer. In addition to dialkylaminoalkyl (meth)acrylamide, the hydrolytically stable cationic monomer may be any monomer that can be considered stable to the OECD hydrolysis test. The cationic monomer may be hydrolytically stable, and the hydrolytically stable cationic monomer may be selected from the group consisting of diallyldimethylammonium chloride and water-soluble cationic styrene derivatives.

[0119] The cationic copolymer can be a terpolymer of acrylamide, 2-dimethylammoniumethyl(meth)acrylate quaternized with methyl chloride (ADAME-Q), and 3-dimethylammoniumpropyl(meth)acrylamide quaternized with methyl chloride (DIMAPA-Q). The cationic copolymer can be formed from acrylamide and acrylamidopropyltrimethylammonium chloride, which has a charge density of about 1.0 meq / g to about 3.0 meq / g.

[0120] The cationic copolymer can have a charge density of from about 1.1 meq / g to about 2.5 meq / g, or from about 1.1 meq / g to about 2.3 meq / g, or from about 1.2 meq / g to about 2.2 meq / g, or from about 1.2 meq / g to about 2.1 meq / g, or from about 1.3 meq / g to about 2.0 meq / g, or from about 1.3 meq / g to about 1.9 meq / g.

[0121] The cationic copolymer can have a molecular weight of from about 100,000 g / mol to about 1,500,000 g / mol, or from about 300,000 g / mol to about 1,500,000 g / mol, or from about 500,000 g / mol to about 1,500,000 g / mol, or from about 700,000 g / mol to about 1,000,000 g / mol, or from about 900,000 g / mol to about 1,200,000 g / mol.

[0122] The cationic copolymer can be trimethylammoniopropyl methacrylamide chloride-N-acrylamide copolymer, also known as AM:MAPTAC. AM:MAPTAC can have a charge density of about 1.3 meq / g and a molecular weight of about 1,100,000 g / mol. The cationic copolymer can be AM:ATPAC. AM:ATPAC can have a charge density of about 1.8 meq / g and a molecular weight of 1,100,000 g / mol.

[0123] (a) Cationic synthetic polymer The hair care composition comprises i) one or more cationic monomer units, and optionally, ii) one or more monomeric units bearing a negative charge, and / or iii) nonionic monomers; The polymer may include a cationic synthetic polymer that may be formed from Here, the charge of the resulting copolymer is positive. The ratio of these three monomers is represented by "m", "p" and "q", where "m" is the number of cationic monomers, "p" is the number of monomers with a negative charge, and "q" is the number of nonionic monomers.

[0124] The cationic polymer may be a water-soluble or dispersible, non-crosslinked synthetic cationic polymer having the following structure:

[0125] [ka] wherein A can be one or more of the following cationic moieties:

[0126] [ka] wherein @ is an amide, alkylamide, ester, ether, alkyl, or alkylaryl; Y is C1-C22 alkyl, alkoxy, alkylidene, alkyl, or aryloxy; Ψ is C1-C22 alkyl, alkyloxy, alkylaryl, or alkylaryloxy; Z is C1-C22 alkyl, alkyloxy, aryl or aryloxy; R1 is H, C1-C4 straight or branched chain alkyl; s is 0 or 1, n is 0 or ≧1, T and R7 are C1-C22 alkyl; X - is a halogen, hydroxide, alkoxide, sulfate or alkyl sulfate.

[0127] In the above structure, the negatively charged monomer is defined by R2' being H, C1-C4 straight or branched chain alkyl, and R3 being:

[0128] [ka] wherein D is O, N, or S; Q is NH or O; u is 1 to 6; t is between 0 and 1, J is an oxygenated functional group containing the elements P, S, C.

[0129] In the above structure, the nonionic monomer is defined by R2″ being H, C1-C4 straight or branched chain alkyl, R6 being straight or branched chain alkyl, alkylaryl, aryloxy, alkyloxy, alkylaryloxy, and β being:

[0130] [ka] It is defined as wherein G′ and G″ are independently O, S, or NH; and L is 0 or 1.

[0131] Examples of cationic monomers include aminoalkyl(meth)acrylates, (meth)aminoalkyl(meth)acrylamides; monomers containing at least one secondary, tertiary, or quaternary amine functional group, or a heterocyclic group containing a nitrogen atom, vinylamine, or ethyleneimine; diallyldialkylammonium salts; mixtures thereof, salts thereof, and macromonomers derived therefrom.

[0132] Further examples of cationic monomers include dimethylaminoethyl (meth)acrylate, dimethylaminopropyl (meth)acrylate, ditertiobutylaminoethyl (meth)acrylate, dimethylaminomethyl (meth)acrylamide, dimethylaminopropyl (meth)acrylamide, ethyleneimine, vinylamine, 2-vinylpyridine, 4-vinylpyridine, trimethylammonium ethyl (meth)acrylate chloride, trimethylammonium ethyl (meth)acrylate methyl sulfate, dimethylammonium ethyl (meth)acrylate benzyl chloride, 4-benzoylbenzyldimethylammonium ethyl acrylate chloride, trimethylammonium ethyl (meth)acrylamido chloride, trimethylammonium propyl (meth)acrylamido chloride, vinylbenzyltrimethylammonium chloride, and diallyldimethylammonium chloride.

[0133] Suitable cationic monomers include those of the formula -NR3 + (wherein R may be the same or different and represents a hydrogen atom, an alkyl group containing 1 to 10 carbon atoms, or a benzyl group, optionally having a hydroxyl group), and includes a quaternary ammonium group having an anion (counter ion). Examples of anions include halides such as chloride and bromide, sulfate, hydrosulfate, alkyl sulfate (e.g., containing 1 to 6 carbon atoms), phosphate, citrate, formate, and acetate.

[0134] Suitable cationic monomers include trimethylammonium ethyl (meth)acrylate chloride, trimethylammonium ethyl (meth)acrylate methyl sulfate, dimethylammonium ethyl (meth)acrylate benzyl chloride, 4-benzoylbenzyldimethylammonium ethyl acrylate chloride, trimethylammonium ethyl (meth)acrylamide chloride, trimethylammonium propyl (meth)acrylamide chloride, vinylbenzyl trimethylammonium chloride.

[0135] Further suitable cationic monomers include trimethylammonium propyl (meth)acrylamide chloride.

[0136] Examples of negatively charged monomers include alpha-ethylenically unsaturated monomers containing a phosphate or phosphonate group, alpha-ethylenically unsaturated monocarboxylic acids, monoalkyl esters of alpha-ethylenically unsaturated dicarboxylic acids, monoalkyl amides of alpha-ethylenically unsaturated dicarboxylic acids, alpha-ethylenically unsaturated compounds containing a sulfonic acid group, and salts of alpha-ethylenically unsaturated compounds containing a sulfonic acid group.

[0137] Suitable negatively charged monomers include acrylic acid, methacrylic acid, vinyl sulfonic acid, salts of vinyl sulfonic acid, vinylbenzene sulfonic acid, salts of vinylbenzene sulfonic acid, α-acrylamidomethylpropane sulfonic acid, salts of α-acrylamidomethylpropane sulfonic acid, 2-sulfoethyl methacrylate, salts of 2-sulfoethyl methacrylate, acrylamido-2-methylpropane sulfonic acid (AMPS), salts of acrylamido-2-methylpropane sulfonic acid, and styrene sulfonate (SS).

[0138] Examples of nonionic monomers include vinyl acetate, amides of alpha-ethylenically unsaturated carboxylic acids, esters of alpha-ethylenically unsaturated monocarboxylic acids with hydrogenated or fluorinated alcohols, polyethylene oxide (meth)acrylates (i.e., polyethoxylated (meth)acrylic acids), monoalkyl esters of alpha-ethylenically unsaturated dicarboxylic acids, monoalkyl amides of alpha-ethylenically unsaturated dicarboxylic acids, vinyl nitriles, vinylamine amides, vinyl alcohol, vinylpyrrolidone, and vinyl aromatic compounds.

[0139] Suitable nonionic monomers include styrene, acrylamide, methacrylamide, acrylonitrile, methyl acrylate, ethyl acrylate, n-propyl acrylate, n-butyl acrylate, methyl methacrylate, ethyl methacrylate, n-propyl methacrylate, n-butyl methacrylate, 2-ethyl-hexyl acrylate, 2-ethyl-hexyl methacrylate, 2-hydroxyethyl acrylate, and 2-hydroxyethyl methacrylate.

[0140] The anionic counterion (X-) associated with the synthetic cationic polymers can be any known counterion, so long as the polymer remains soluble or dispersible in water, the hair care composition, or the coacervate phase of the hair care composition, and so long as the counterion is physically and chemically compatible with the essential ingredients of the hair care composition or does not otherwise unduly impair the performance, stability, or aesthetics of the product. Non-limiting examples of such counterions include halides (e.g., chlorine, fluorine, bromine, iodine), sulfate, and methylsulfate.

[0141] The cationic polymers described herein can help provide a substitute hydrophobic F-layer to damaged hair, particularly chemically treated hair. The microscopically thin F-layer provides natural weather resistance while helping to seal in moisture and prevent further damage. Chemical treatments damage the hair cuticle, stripping the hair of its protective F-layer. As the F-layer strips away, the hair becomes more hydrophilic. Application of lyotropic liquid crystals to chemically treated hair has been shown to make the hair more hydrophobic, resembling untreated hair in appearance and feel. Without being bound by any theory, it is believed that the lyotropic liquid crystal complex forms a hydrophobic layer or film that coats and protects the hair fiber in the same way that a natural F-layer protects hair. The hydrophobic layer restores the hair to a healthier state, almost like untreated hair. Lyotropic liquid crystals are formed by combining the synthetic cationic polymers described herein with the above-mentioned anionic cleansing surfactant components of hair care compositions.The charge density of synthetic cationic polymers is relatively high.It should be noted that some synthetic polymers with relatively high cationic charge density do not form lyotropic liquid crystals, mainly due to their abnormal linear charge density.Such synthetic cationic polymers are described in WO 94 / 06403 (Reich et al.).The synthetic polymers described herein can be formulated into stable hair care compositions that improve the conditioning performance of damaged hair.

[0142] The cationic synthetic polymer capable of forming lyotropic liquid crystals may have a cationic charge density of about 2 meq / gm to about 7 meq / gm, and / or about 3 meq / gm to about 7 meq / gm, and / or about 4 meq / gm to about 7 meq / gm. The cationic charge density may be about 6.2 meq / gm. The polymer may also have a molecular weight of about 1,000 to about 5,000,000, and / or about 10,000 to about 1,500,000, and / or about 100,000 to about 1,500,000.

[0143] Cationic synthetic polymers that provide conditioning and enhanced deposition of benefit agents, but do not necessarily form lyotropic liquid crystals, may have a cationic charge density of from about 0.7 meq / gm to about 7 meq / gm, and / or from about 0.8 meq / gm to about 5 meq / gm, and / or from about 1.0 meq / gm to about 3 meq / gm. The polymers also have molecular weights of from about 1,000 to about 1,500,000, from about 10,000 to about 1,500,000, and from about 100,000 to about 1,500,000.

[0144] A suitable cationic cellulose polymer is a salt of hydroxyethyl cellulose reacted with a trimethylammonium-substituted epoxide, referred to in the industry (CTFA) as Polyquaternium 10, available from Dow / Amerchol Corp. (Edison, NJ, USA) in the Polymer LR, JR, and KG series of polymers. Non-limiting examples include JR-400, JR-125, JR-30M, KG-30M, JP, LR-400, and mixtures thereof. Another suitable type of cationic cellulose is a polymeric quaternary ammonium salt of hydroxyethyl cellulose reacted with a lauryldimethylammonium-substituted epoxide, referred to in the industry (CTFA) as Polyquaternium 24. These materials are available from Dow / Amerchol Corp. under the trade name Polymer LM-200. Other suitable types of cationic cellulose include polymeric quaternary ammonium salts of hydroxyethyl cellulose reacted with lauryldimethylammonium- and trimethylammonium-substituted epoxides, known in the art (CTFA) as Polyquaternium 67. These materials are available from Dow / Amerchol Corp. under the trade names SoftCAT Polymer SL-5, SoftCAT Polymer SL-30, Polymer SL-60, Polymer SL-100, Polymer SK-L, Polymer SK-M, Polymer SK-MH, and Polymer SK-H.

[0145] Suitable cationic cellulose polymers may have a cationic charge density of from about 0.5 meq / gm to about 2.5 meq / gm, and / or from about 0.6 meq / gm to about 2.2 meq / gm, and / or from about 0.6 meq / gm to about 2.0 meq / gm. Furthermore, the cationic charge density may be about 1.9 meq / gm. The polymers may also have a molecular weight of from about 200,000 to about 3,000,000, and / or from about 300,000 to about 2,200,000, and / or from about 1,000,000 to about 2,200,000, and / or from about 300,000 to about 1,500,000. The cationic cellulose polymer can have a cationic charge density of from about 1.7 to about 2.1 meq / g and a molecular weight of from about 1,000,000 to about 2,000,000.

[0146] The concentration of the cationic polymer ranges from about 0.01% to about 5%, from about 0.08% to about 3%, from about 0.1% to about 2%, and / or from about 0.2% to about 1% by weight of the hair care composition.

[0147] The concentration of the cationic polymer ranges from about 0.01% to about 5%, from about 0.08% to about 3%, from about 0.1% to about 2%, and / or from about 0.2% to about 1% by weight of the hair care composition.

[0148] Thickening Polymer The hair care composition may include a thickening polymer to increase the viscosity of the composition. Any suitable thickening polymer may be used. The hair care composition may include about 0.25% to about 10% thickening polymer, about 0.5% to about 8% thickening polymer, about 1.0% to about 5% thickening polymer, and about 1% to about 4% thickening polymer. The thickening polymer modifier may be a polyacrylate or polyacrylamide thickener. The thickening polymer may be an anionic thickening polymer.

[0149] The hair care composition may include a thickening polymer that is a homopolymer based on acrylic acid, methacrylic acid, or other related derivatives, non-limiting examples of which include polyacrylates, polymethacrylates, polyethylacrylates, and polyacrylamides.

[0150] The thickening polymer may be an alkali-swellable and hydrophobically modified alkali-swellable acrylic or methacrylate copolymer, non-limiting examples of which include acrylic acid / acrylonitrile copolymer, acrylates / steareth-20 itaconate copolymer, acrylates / ceteth-20 itaconate copolymer, acrylates / aminoacrylate / C10-30 alkyl PEG-20 itaconate copolymer, acrylates / aminoacrylate copolymer, acrylates / steareth-20 methacrylate ... Acrylates / Beheneth-25 Methacrylate Copolymer, Acrylates / Steareth-20 Methacrylate Crosspolymer, Acrylates / Beheneth-25 Methacrylate / HEMA Crosspolymer, Acrylates / Vinyl Neodecanoate Crosspolymer, Acrylates / Vinyl Isodecanoate Crosspolymer, Acrylates / Palmetha-25 Acrylate Copolymer, Acrylic Acid / Acrylamidomethyl Propanesulfonic Acid Copolymer, and Acrylates / C10-C30 Alkyl Acrylate Crosspolymer.

[0151] The thickening polymer may be a soluble crosslinked acrylic polymer, a non-limiting example of which is carbomer.

[0152] The thickening polymer may be an associative polymeric thickener, non-limiting examples of which include hydrophobically modified alkali swellable emulsions, non-limiting examples of which include hydrophobically modified polyacrylates; hydrophobically modified polyacrylic acids, and hydrophobically modified polyacrylamides; hydrophobically modified polyethers, which may have a hydrophobe selected from cetyl, stearyl, oleayl, and combinations thereof.

[0153] The thickening polymer can be used in combination with polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone, and derivatives. The thickening polymer may be combined with polyvinyl alcohol and derivatives. The thickening polymer may be combined with polyethyleneimine and derivatives.

[0154] Thickening polymers may be combined with alginate-based materials, non-limiting examples of which include sodium alginate and propylene glycol alginate.

[0155] Thickening polymers can be used in combination with polyurethane polymers, non-limiting examples of which include hydrophobically modified alkoxylated urethane polymers, non-limiting examples of which include PEG-150 / decyl alcohol / SMDI copolymer, PEG-150 / stearyl alcohol / SMDI copolymer, polyurethane-39.

[0156] The thickening polymer may be combined with an associative polymeric thickener, non-limiting examples of which include hydrophobically modified cellulose derivatives and hydrophilic moieties of repeating ethylene oxide groups having repeating units of about 10 to about 300, about 30 to about 200, and about 40 to about 150. Non-limiting examples of this category include PEG-120-methyl glucose dioleate, PEG-(40 or 60) sorbitan tetraoleate, PEG-150 pentaerythrityl tetrastearate, PEG-55 propylene glycol oleate, PEG-150 distearate.

[0157] The thickening polymer may be combined with cellulose and derivatives, non-limiting examples of which include microcrystalline cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, ethyl cellulose; nitrocellulose; cellulose sulfate; cellulose powder; hydrophobically modified cellulose.

[0158] The thickening polymer may be combined with guar and guar derivatives, non-limiting examples of which include hydroxypropyl guar and hydroxypropyl guar hydroxypropyltrimonium chloride.

[0159] The thickening polymer may be combined with polyethylene oxide, polypropylene oxide, and POE-PPO copolymers.

[0160] The thickening polymer may be combined with a polyalkylene glycol characterized by the general formula:

[0161] [ka] wherein R is hydrogen, methyl, or a mixture thereof, preferably hydrogen, and n is an integer averaging 2,000 to 180,000, or 7,000 to 90,000, or 7,000 to 45,000. Non-limiting examples of this category include PEG-7M, PEG-14M, PEG-23M, PEG-25M, PEG-45M, PEG-90M, and PEG-100M.

[0162] The thickening polymer may be combined with silica, non-limiting examples of which include fumed silica, precipitated silica, and silicone surface treated silica.

[0163] The thickening polymer may be combined with a water-swellable clay, non-limiting examples of which include laponite, bentonite, montmorillonite, smectite, and hectonite.

[0164] The thickening polymer may be combined with a gum, non-limiting examples of which include xanthan gum, guar gum, hydroxyprolyl guar gum, gum arabic, tragacanth, galactan, carob gum, karaya gum, and locust bean gum.

[0165] The thickening polymers may be combined with dibenzylidene sorbitol, carrageenan, pectin, agar, quince seed (Cydonia oblonga Mill), starch (obtained from rice, corn, potato, wheat, etc.), starch derivatives (e.g., carboxymethyl starch, methylhydroxypropyl starch), algae extracts, dextran, succinoglucan, and prelan.

[0166] Non-limiting examples of thickening polymers include acrylamide / ammonium acrylate copolymer (and) polyisobutene (and) polysorbate 20; acrylamide / sodium acryloyldimethyltaurate copolymer / isohexadecane / polysorbate 80, ammonium acryloyldimethyltaurate / VP copolymer, sodium acrylate / sodium acryloyldimethyltaurate copolymer, acrylate copolymer, acrylate crosspolymer-4, acrylate crosspolymer-3, acrylates / beheneth-25 methacrylate copolymer, acrylates / C10-C30 alkyl acrylate crosspolymer, acrylates / steareth-20 itaconate copolymer, poly Ammonium acrylate / isohexadecane / PEG-40 castor oil; carbomer, sodium carbomer, cross-linked polyvinylpyrrolidone (PVP), polyacrylamide / C13-14 isoparaffin / laureth-7, polyacrylate 13 / polyisobutene / polysorbate 20, polyacrylate crosspolymer-6, polyamide-3, polyquaternium-37 (and) hydrogenated polydecene (and) trideceth-6, acrylamide / sodium acryloyldimethyltaurate / acrylic acid copolymer, sodium acrylate / acryloyldimethyltaurate / dimethylacrylamide crosspolymer (and) isohexadecane (and) polysorbate 60, sodium polyacrylate.Exemplary commercially available thickening polymers include ACULYN™ 28, ACULYN™ 33, ACULYN™ 88, ACULYN™ 22, ACULYN™ Excel, Carbopol® AquaSF-1, Carbopol® ETD 2020, Carbopol® Ultrez 20, Carbopol® Ultrez 21, Carbopol® Ultrez 10, Carbopol® Ultrez 30, Carbopol® 1342, Carbopol® AquaSF-2 polymer, Sepigel™ 305, Simulgel™ 600, Sepimax™ Zen, Carbopol® SMART 1000, Rheocare® TTA, Rheomer® SC-Plus, STRUCTURE® PLUS, Aristoflex® AVC, Stabylen 30, and combinations thereof.

[0167] Gel Network In the present invention, a gel network may be present. The gel network component of the present invention comprises at least one aliphatic amphiphile. As used herein, "aliphatic amphiphile" refers to an alkyl, alkenyl (containing up to three double bonds), alkyl aromatic, or C 12 ~C 70 and a hydrophilic head group that does not render the compound water soluble, and the compound also has a net neutral charge at the pH of the shampoo composition.

[0168] The shampoo compositions of the present invention comprise fatty amphiphiles as part of a pre-formed dispersed gel network phase in amounts of from about 0.05% to about 14%, from about 0.5% to about 10%, and from about 1% to about 8%, by weight of the shampoo composition.

[0169] According to the present invention, a suitable fatty amphiphile, or a suitable mixture of two or more fatty amphiphiles, has a melting point of at least about 27° C. As used herein, melting point is defined as the melting point of the US Pharmacopeia, USP-NF General Chapter <741> The melting point of a mixture of two or more materials can be measured by the standard melting point method described in "Melting range or temperature." The melting point of a mixture of two or more materials is measured by mixing the two or more materials at a temperature equal to or greater than their individual melting points and then cooling the mixture. If the resulting composite is a homogeneous solid below about 27°C, the mixture has a melting point suitable for use in the present invention. A mixture of two or more fatty amphiphiles, including at least one fatty amphiphile with an individual melting point below about 27°C, is also suitable for use in the present invention, provided that the composite melting point of the mixture is at least about 27°C.

[0170] Suitable fatty amphiphiles of the present invention include fatty alcohols, alkoxylated fatty alcohols, fatty phenols, alkoxylated fatty phenols, fatty amides, alkyoxylated fatty amides, fatty amines, fatty alkylamidoalkylamines, fatty alkyoxylated amines, fatty carbamates, fatty amine oxides, fatty acids, alkoxylated fatty acids, fatty diesters, fatty sorbitan esters, fatty sugar esters, methyl glucoside esters, fatty glycol esters, mono-, di-, and tri-glycerides, polyglycerol fatty esters, alkyl glyceryl ethers, propylene glycol fatty acid esters, cholesterol, ceramides, fatty silicone waxes, fatty glucose amides, and phospholipids, and mixtures thereof.

[0171] The shampoo composition may contain a fatty alcohol gel network. These gel networks are formed by combining a fatty alcohol and a surfactant in a ratio of about 1:1 to about 40:1, about 2:1 to about 20:1, and / or about 3:1 to about 10:1. Formation of the gel network involves heating an aqueous dispersion of a fatty alcohol with the surfactant to a temperature above the melting point of the fatty alcohol. During this mixing process, the fatty alcohol melts, partitioning the surfactant into fatty alcohol droplets. The surfactant then entrains water into the fatty alcohol, transforming the isotropic fatty alcohol droplets into liquid crystalline phase droplets. When the mixture is cooled below the chain melting temperature, the liquid crystalline phase transforms into a solid crystalline gel network. The gel network provides a stabilizing effect to cosmetic creams and hair conditioners. Additionally, it provides tailored feel benefits to hair conditioners.

[0172] The fatty alcohol may be included in the fatty alcohol gel network at a concentration of about 0.05% to about 14% by weight. For example, the fatty alcohol may be present in an amount ranging from about 1% to about 10% by weight, and / or from about 6% to about 8% by weight.

[0173] Fatty alcohols useful in the present invention include those having about 10 to about 40 carbon atoms, about 12 to about 22 carbon atoms, about 16 to about 22 carbon atoms, and / or about 16 to about 18 carbon atoms. These fatty alcohols may be straight-chain or branched-chain alcohols, saturated or unsaturated. Non-limiting examples of fatty alcohols include cetyl alcohol, stearyl alcohol, behenyl alcohol, and mixtures thereof. A mixture of cetyl alcohol and stearyl alcohol in a ratio of about 20:80 to about 80:20 is preferred.

[0174] Preparation of gel network: Fill a container with water and heat the water to approximately 74°C. Add cetyl alcohol, stearyl alcohol, and SLES surfactant to the heated water. After incorporation, pass the resulting mixture through a heat exchanger, where the mixture is cooled to approximately 35°C. Upon cooling, the fatty alcohol and surfactant crystallize to form a crystalline gel network. Table 1 lists the components and respective amounts of an exemplary gel network composition.

[0175] [Table 1]

[0176] 1. Water-miscible solvents Carriers useful in hair care compositions include water and aqueous solutions of lower alkyl alcohols, polyhydric alcohols, ketones having 3 to 4 carbon atoms, C1 to C6 esters of C1 to C6 alcohols, sulfoxides, amides, carbonates, ethoxylated and propoxylated C1 to C10 alcohols, lactones, pyrrolidones, and mixtures thereof. Non-limiting examples of lower alkyl alcohols are monohydric alcohols having 1 to 6 carbon atoms, such as ethanol and isopropanol. Non-limiting examples of polyhydric alcohols useful herein include propylene glycol, dipropylene glycol, butylene glycol, hexylene glycol, glycerin, propanediol, and mixtures thereof.

[0177] The hair care composition may include a hydrotrope / viscosity modifier which is an alkali metal or ammonium salt of a lower alkyl benzene sulfonate such as sodium xylene sulfonate, sodium cumene sulfonate, or sodium toluene sulfonate.

[0178] The hair care composition can include silicones / PEG-8 silicones / PEG-9 silicones / PEG-n silicones / silicone ethers (n can be another integer), non-limiting examples include PEG8-Dimethicone A208MW855, PEG8 Dimethicone D208MW2706.

[0179] C. Scalp health supplement In the present invention, one or more scalp health agents may be added to provide scalp benefits in addition to the antifungal / antidandruff benefits provided by the surfactant-soluble antidandruff agent. This group of materials is diverse and provides a wide range of benefits, including moisturizing, barrier improvement, antifungal, antibacterial, antioxidant, anti-itch, and sensate effects. Non-limiting examples of additional antidandruff agents, such as polyvalent metal salts of pyrithione, include zinc pyrithione (ZPT) and copper pyrithione, sulfur, or selenium sulfide. Such scalp health agents include vitamins E and F, salicylic acid, niacinamide, caffeine, panthenol, zinc oxide, zinc carbonate, zinc carbonate basic, glycol, glycolic acid, PCA, PEG, erythritol, glycerin, triclosan, lactate, hyaluronate, allantoin and other ureas, betaine, sorbitol, glutamate, xylitol, menthol, menthyl lactate, isocyclomone, benzyl alcohol, and compounds containing the following structure:

[0180] [ka] R1 is selected from H, alkyl, aminoalkyl, alkoxy; Q=H2, O, -OR1, -N(R1)2, -OPO(OR1) x , -PO(OR1) x , -P(OR1) x (In the formula, x=1~2), V=NR1, O, -OPO(OR1) x , -PO(OR1) x , -P(OR1) x (In the formula, x=1~2), W=H2, O, When n=0, X and Y are independently selected from H, aryl, and naphthyl; When n≧1, X and Y are aliphatic CH or aromatic CH, and Z is selected from aliphatic CH, aromatic CH, or a heteroatom; A=lower alkoxy, lower alkylthio, aryl, substituted aryl, or fused aryl; * (The stereochemistry is variable at the marked positions.) and natural extracts / oils including, but not limited to, peppermint, spearmint, argan, jojoba and aloe.

[0181] D. Optional ingredients In the present invention, the hair care composition may further comprise one or more optional ingredients, such as a benefit agent. Suitable benefit agents include, but are not limited to, conditioning agents, cationic polymeric silicone emulsions, surfactant-miscible solvents, antidandruff agents, gel networks, chelating agents, and natural oils such as sunflower oil or castor oil. Further suitable optional ingredients include, but are not limited to, perfumes, perfume microcapsules, colorants, particles, antimicrobial agents, foam busters, antistatic agents, rheology modifiers and thickeners, suspending materials and structuring agents, pH adjusters and buffers, preservatives, pearlescent agents, solvents, diluents, antioxidants, vitamins, and combinations thereof. The composition may have from about 0.5% to about 7% perfume.

[0182] Such optional ingredients must be physically and chemically compatible with the components of the composition and must not otherwise unduly impair product stability, aesthetics, or performance. The CTFA Cosmetic Ingredient Handbook, 10th Edition (published by the Cosmetic, Toiletry, and Fragrance Association, Inc., Washington, DC) (2004) (hereinafter "CTFA") describes a variety of non-limiting materials that may be added to the compositions herein.

[0183] 1. Surfactant-miscible solvent The hair care composition may also contain surfactant-miscible solvents, which dissolve in surfactant micelles. These materials include hydrocarbons and functionalized hydrocarbons with sufficient alkyl moieties so that they are not water-soluble, but instead disperse in water and dissolve / become miscible in the presence of surfactants. These materials include, but are not limited to, 1,10-decanediol, 1,12-dodecanediol, 1,2-heptadecanediol, 1,14-heptadecanediol, and 1,17-heptadecanediol, hexane-1,3,5-triol, and polyols. Representative surfactant-miscible solvents may overlap with the definition of surfactant-soluble active agents. The difference between these two definitions is the importance of delivering the material to the target substrate, which is important for surfactant-soluble active agents.

[0184] The concentration of the surfactant-miscible solvent ranges from about 0.01% to about 10%, from about 0.1% to about 3%, from about 0.5% to about 4%, and / or from about 1% to about 2% by weight of the hair care composition.

[0185] 2. Conditioning agents The conditioning agent of the hair care composition may be a silicone conditioning agent. The silicone conditioning agent may include a volatile silicone, a non-volatile silicone, or a combination thereof. The concentration of the silicone conditioning agent is typically in the range of about 0.01% to about 10%, about 0.1% to about 8%, about 0.1% to about 5%, and / or about 0.2% to about 3% by weight of the composition. Non-limiting examples of suitable silicone conditioning agents and optional suspending agents for silicones are described in U.S. Reissue Patent No. 34,584, U.S. Pat. No. 5,104,646, and U.S. Pat. No. 5,106,609, which are incorporated herein by reference.

[0186] Silicone conditioning agents for use in the compositions of the present invention may have a viscosity, measured at 25° C., of from about 20 to about 2,000,000 centistokes (“csk”), from about 1,000 to about 1,800,000 csk, from about 10,000 to about 1,500,000 csk, and / or from about 20,000 to about 1,500,000 csk.

[0187] The dispersed silicone conditioning agent particles typically have a volume average particle size ranging from about 0.01 micrometers to about 60 micrometers. For application of small particles to hair, the volume average particle size typically ranges from about 0.01 micrometers to about 4 micrometers, from about 0.01 micrometers to about 2 micrometers, or from about 0.01 micrometers to about 0.5 micrometers.

[0188] Further information on silicones, including sections discussing silicone fluids, rubbers, and resins, and the manufacture of silicones, can be found in Encyclopedia of Polymer Science and Engineering, vol. 15, 2d ed., pp 204-308, John Wiley & Sons, Inc. (1989), which is incorporated herein by reference.

[0189] The silicone emulsion suitable for use in the present invention includes but is not limited to the emulsion of insoluble polysiloxane.They can be prepared by emulsion polymerization according to the description provided in US Patent No. 6,316,541, or US Patent No. 4,476,282, or US Patent Application Publication No. 2007 / 0276087, or they can be emulsified after polymerization is completed through various emulsification methods, such as those described in US Patent No. 9,255,184 (B2), or US Patent No. 7,683,119, or Emulsions and Emulsion Stability, edited by Johan Sjoblom, CRC Press, 2005.These references can be considered as a non-limiting list of suitable emulsifiers and emulsifier formulations based on the functionality of silicone used, emulsification method, and desired emulsion particle size. Therefore, suitable insoluble polysiloxanes include polysiloxanes such as α,ω hydroxy-terminated polysiloxanes or α,ω alkoxy-terminated polysiloxanes having an internal phase viscosity of about 5 csk to about 500,000 csk. For example, the insoluble polysiloxane may have an internal phase viscosity of less than 400,000 csk, less than 200,000 csk, or about 10,000 csk to about 180,000 csk. The insoluble polysiloxane may have an average particle size in the range of about 10 nm to about 10 micrometers. The average particle size may be, for example, about 15 nm to about 5 micrometers, about 20 nm to about 1 micrometer, about 25 nm to about 550 nm, or about 1 to 10 micrometers. The concentration of dispersed silicone in the emulsion may be in the range of about 5 to 90 weight percent, 20 to 85 weight percent, or 30 to 80 weight percent of the emulsion composition.

[0190] The average molecular weight of the insoluble polysiloxane, the internal phase viscosity of the insoluble polysiloxane, the viscosity of the silicone emulsion, and the size of particles containing the insoluble polysiloxane are measured by methods commonly used by those skilled in the art, such as the method disclosed in Smith, A.L., The Analytical Chemistry of Silicones, John Wiley & Sons, Inc.: New York, 1991. For example, the viscosity of the silicone emulsion can be measured at 30° C. using a Brookfield viscometer equipped with spindle 6 at 2.5 rpm. The silicone emulsion may further contain an additional emulsifier along with the anionic surfactant.

[0191] Other classes of silicones suitable for use in the compositions of the present invention include: i) silicone fluids (including, but not limited to, silicone oils), which are flowable materials having a viscosity of less than about 1,000,000 csk when measured at 25° C.; ii) aminosilicones, which contain at least one primary, secondary, or tertiary amine; iii) cationic silicones, which contain at least one quaternary ammonium functional group; iv) silicone gums (including materials having a viscosity of 1,000,000 csk or greater when measured at 25° C.); v) silicone resins, which include highly crosslinked polymeric siloxane systems; vi) high refractive index silicones, which have a refractive index of at least 1.46; and vii) mixtures thereof.

[0192] The conditioning agent of the hair care composition of the present invention may further comprise at least one organic conditioning material, such as an oil or wax, either alone or in combination with other conditioning agents, such as the silicones described above. The organic material may be non-polymeric, oligomeric, or polymeric. It may be in the form of an oil or wax and may be added to the formulation as is or in a pre-emulsified form. Some non-limiting examples of organic conditioning materials include: i) hydrocarbon oils; ii) polyolefins; iii) fatty esters; iv) fluorinated conditioning compounds; v) fatty alcohols; vi) alkyl glucosides and alkyl glucoside derivatives; vii) quaternary ammonium compounds; and viii) polyethylene glycols and polypropylene glycols having a molecular weight of up to about 2,000,000, such as those having the CTFA designations PEG-200, PEG-400, PEG-600, PEG-1000, PEG-2M, PEG-7M, PEG-14M, PEG-45M, and mixtures thereof.

[0193] 3. Emulsifiers Anionic surfactants other than those listed above as "detergent surfactants" Various anionic and nonionic emulsifiers can be used in the hair care compositions of the present invention. The anionic and nonionic emulsifiers can be either monomeric or polymeric in nature. Examples of monomers include, but are not limited to, alkyl ethoxylates, soaps, and fatty acid esters, and their derivatives. Examples of polymers include, but are not limited to, polyacrylates, polyethylene glycols, and block copolymers, and their derivatives. Natural emulsifiers such as lanolin, lecithin, and lignin, and their derivatives, are also non-limiting examples of useful emulsifiers.

[0194] 4. Chelating Agents The hair care composition may further comprise a chelating agent. Suitable chelating agents include those described in A.E. Martell & R.M. Smith, Critical Stability Constants, Vol. 1, Plenum Press, New York & London (1974) and A.E. Martell & R.D. Hancock, Metal Complexes in Aqueous Solution, Plenum Press, New York & London (1996), both of which are incorporated herein by reference. With respect to chelating agents, the term "salts and derivatives thereof" refers to salts and derivatives that contain the same functional structure (e.g., the same chemical backbone) as the referenced chelating agent and have similar or superior chelating properties. This term includes alkali metal, alkaline earth, ammonium, substituted ammonium salts (i.e., monoethanolammonium, diethanolammonium, triethanolammonium) salts, esters of chelating agents with acidic moieties, and mixtures thereof, particularly all sodium, potassium, or ammonium salts. The term "derivative" also includes "chelating surfactant" compounds such as those exemplified in U.S. Pat. No. 5,284,972, and larger molecules containing one or more chelating groups with the same functional structure as the parent chelator, such as the polymer EDDS (ethylenediaminedisuccinic acid) disclosed in U.S. Pat. No. 5,747,440.

[0195] Chelating agents can be incorporated into the compositions described herein in amounts ranging from 0.001% to 10.0% by weight of the total composition, about 0.01% to 2.0%.

[0196] Non-limiting classes of chelating agents include carboxylic acids, aminocarboxylic acids, such as aminocids, phosphoric acids, phosphonic acids, polyphosphonic acids, polyethyleneimines, polyfunctionally substituted aromatics, derivatives and salts thereof.

[0197] Non-limiting chelating agents include the following materials and their salts: ethylenediaminetetraacetic acid (EDTA), ethylenediaminetriacetic acid, ethylenediamine-N,N'-disuccinic acid (EDDS), ethylenediamine-N,N'-diglutaric acid (EDDG), salicylic acid, aspartic acid, glutamic acid, glycine, malonic acid, histidine, diethylenetriaminepentaacetate (DTPA), N-hydroxyethylethylenediaminetriacetate, nitrilotriacetate, ethylenediaminetetrapropionate, triethylenetetraamine Benzyl alcohol, methyl glycine diacetate, propylenediaminetetraacetic acid (PDTA), methylglycine diacetate (MODA), diethylenetriaminepentaacetic acid, methylglycine diacetate (MGDA), N-acyl-N,N',N'-ethylenediaminetriacetic acid, nitrilotriacetic acid, ethylenediaminediglutaric acid (EDGA), 2-hydroxypropylenediaminedisuccinic acid (HPDS), glycinamide-N,N'-disuccinic acid (GADS), 2-hydroxypropylenediamine- N-N'-Disuccinic acid (HPDDS), N-2-hydroxyethyl-N,N-diacetic acid, glyceryl iminodiacetic acid, iminodiacetic acid-N-2-hydroxypropyl sulfonic acid, aspartic acid N-carboxymethyl-N-2-hydroxypropyl-3-sulfonic acid, alanine-N,N'-diacetic acid, aspartic acid-N,N'-diacetic acid, aspartic acid N-monoacetic acid, iminodisuccinic acid, diamine-N,N'-dipolyacid, monoamide-N,N'-dipolyacid, diaminoalkyldi(sulfonic acid) DDS), ethylenediamine-N,N'-bis(ortho-hydroxyphenylacetic acid), N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, ethylenediaminetetraproprionate, triethylenetetraaminehexaacetate, diethylenetriaminepentaacetate, dipicolinic acid, ethylenedicysteic acid (EDC), ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid) (EDDHA), glutamic acid diacetate (GLDA), hexadentate aminocarboxylate (HBED), polyethyleneimine, 1-hydroxydiphosphonate, aminotri(methylenephosphonic acid) (ATMP), nitrilotrimethylenephosphonate (NTP), ethylenediaminetetramethylenephosphonate, diethylenetriaminepentamethylenephosphonate (DTPMP), ethane-1-hydroxydiphosphonate (HEDP), 2-phosphonobutane-1,2,4-tricarboxylic acid, polyphosphoric acid (polvphosphoric acid), sodium tripolyphosphate, tetrasodium diphosphate, hexametaphosphate, sodium metaphosphate, phosphonic acid and derivatives, aminoalkylene-poly(alkylenephosphonic acid), aminotri(1-ethylphosphonic acid), ethylenediaminetetra(1-ethylphosphonic acid), aminotri(1-propylphosphonic acid), aminotri(isopropylphosphonic acid), ethylenediaminetetra(methylenephosphonic acid) (EDTMP), 1,2-dihydroxy-3,5-disulfobenzene.

[0198] Water-based carrier The hair care composition may be in the form of a pourable liquid (under ambient conditions). Accordingly, such compositions typically include a carrier, which is present in a concentration of about 40% to about 85%, alternatively about 45% to about 80%, alternatively about 50% to about 75% by weight of the hair care composition. The carrier may include water or a miscible mixture of water and an organic solvent, although in one embodiment, the carrier may include water with minimal or no significant concentrations of organic solvent, except when incidentally incorporated into the composition as a minor component of other essential or optional ingredients.

[0199] Carriers that may be useful in the hair care compositions of the present invention include water and aqueous solutions of lower alkyl alcohols and polyhydric alcohols. Lower alkyl alcohols useful herein are monohydric alcohols having 1 to 6 carbon atoms, in one embodiment, ethanol and isopropanol. Exemplary polyhydric alcohols useful herein include propylene glycol, hexylene glycol, glycerin, and propanediol.

[0200] G. Product form The hair care composition of the present invention can be present in a typical hair care formulation. This composition can be in the form of a solution, dispersion, emulsion, powder, talc, capsule, sphere, sponge, solid dosage form, foam, and other delivery mechanisms. The composition of the present invention can be in the form of leave-on hair products such as hair tonics, treatment and styling products, rinse-off hair products such as shampoos and personal cleansing products, and treatment products, as well as any other form that can be applied to hair.

[0201] The solubilization ability (K s i ) measurement K s i Solutions for measurement are prepared by adding 1% and / or 2% by weight of surfactant to a citrate-phosphate buffer solution at pH 5.5. Citric acid is then added, if necessary, to adjust the pH of the resulting surfactant solution to pH 5.5. The surfactant-soluble agent is then added in excess (0.5% by weight or more) to these solutions, followed by sonication for several minutes. If the pH of the resulting solution exceeds 6.5, additional citric acid is added to lower the pH below this threshold. The dispersion is then equilibrated at room temperature for 24-48 hours. As expected, particulate octopirox is still clearly visible after the equilibration period. The concentration of the surfactant-soluble agent dissolved in the supernatant is then analytically determined.

[0202] [Table 2]

[0203] [Table 3]

[0204] Calculation of partial soluble agent concentration (α) After measuring the solubilizing capacity of a solubilizing agent in a surfactant or surfactant blend, the information can be converted to a fractional solubilizing agent concentration (α), where "α" is

[0205]

number

[0206] Sample calculation for partially soluble agent concentration (α):

[0207]

number

[0208] Measurement of adhesion of surfactant-soluble agents The deposition of surfactant-soluble agent on scalp in vivo can be measured by treating scalp with surfactant-soluble agent containing cleansing composition, rinsing, and then extracting the soluble agent with ethanol.The concentration of agent in the ethanol extraction solvent is measured by HPLC.Quantification is performed based on a standard curve.The concentration detected by HPLC is converted into the collected amount in grams by multiplying the concentration by volume.

[0209] Deposition efficiency can be calculated using the following equation: The area of ​​scalp extracted in each case is held constant.

[0210]

number

[0211] Sample calculation of deposition efficiency: Mass of Octopirox deposited in example formulation = 1.2 μg Mass of Octopirox deposited in control formulation = 0.7 μg

[0212]

number

[0213] Preparation of Deposition Control Cleaning Composition A deposition control composition is prepared by creating a formulation with the same surfactant-soluble agent type and concentration and surfactant concentration as the test composition, except that the control formulation utilizes sodium laureth-1 sulfate as the surfactant. The formulation is adjusted to a pH of about 6. For example, the formulation designated Example 26 is a deposition control composition relative to the test composition designated Example 25. The preparation technique matches the protocol used to prepare the test simple cleaning composition.

[0214] Preparation of Exemplary Cleaning Compositions An exemplary cleaning composition is prepared by mixing the surfactant, surfactant-soluble active, and the remaining water with sufficient agitation to ensure a homogeneous mixture. The mixture can be heated to 50-75°C to accelerate solubilization of the surfactant-soluble active, and then cooled. The pH of the product is then adjusted as needed to result in a composition with a pH of about 6.

[0215] Non-limiting examples The shampoo compositions illustrated in the following examples are prepared by conventional formulation and mixing methods. All exemplified amounts are listed as weight percent on an active basis and exclude minor materials such as diluents, preservatives, color solutions, image ingredients, botanicals, etc. unless otherwise specified. All percentages are by weight unless otherwise specified.

[0216] [Table 4]

[0217] Consideration of Examples 17 to 25 There is a strong correlation between partially soluble agent concentration and in vivo detergent-soluble agent deposition. These examples highlight the influence of surfactant type. Examples 17-25 show a wide range of partially soluble agent concentrations and the corresponding in vivo detergent-soluble deposition values, demonstrating the intrinsic solubilizing capacity (K) of the surfactant. s i The importance of

[0218] [Table 5]

[0219] Consideration of Examples 26-27 In Examples 26 and 27, the octopirox concentration (C) and the type of surfactant (K s i ) is held constant, a dramatic increase in the concentration of partially soluble agents and surfactant-soluble agent deposition is observed, and C s i , the importance of surfactant concentration is emphasized.

[0220] [Table 6]

[0221] Consideration of Examples 28 to 31 In Examples 28-31, multiple strategies were used to achieve high partially soluble agent concentrations: high soluble activity levels (C), low surfactant concentrations (Cs i ), and / or low intrinsic solubilization capacity (K s i These high values ​​are also reflected in the high in vivo adhesion results.

[0222] When all of the data from Examples 17-31 are plotted collectively, a good correlation between partially soluble agent concentration and in vivo detergent-soluble agent deposition is evident (Figure 1).

[0223] FIG. 1 shows the partially soluble agent concentration versus in vivo detergent-soluble agent deposition for Examples 17-31.

[0224] The correlation between partially soluble agent concentration and in vivo soluble agent deposition is high, and measurements of partially soluble agent concentration are relatively easy to obtain. Unlike in vivo deposition measurements, partially soluble agent concentration is measured using simple solutions prepared and analyzed in the laboratory, making this latter process much cheaper, faster, and more flexible since it does not require consideration of human use. The ability to assess and predict in vivo behavior with this simple laboratory measurement is surprising and advantageous for product development.

[0225] As the equation for calculating the partial soluble agent concentration shows, the three components (C, C) s i , and K s i ) all have an impact. Due to practical constraints, formulators are often limited to the surfactant concentration (C s i ) and surfactant-soluble agent concentration (C) are set, leaving little formulation flexibility. The discovery of this surprising and exploitable correlation between partially soluble agent concentration (α) and in vivo soluble agent deposition provides formulators with a new dimension: greater freedom in surfactant selection. By quickly measuring the solubilizing capacity of each surfactant, formulators can now achieve deposition goals with much less guesswork and in vivo testing, accelerating formulation development and improving formulation quality, particularly with regard to agent deposition.

[0226] As Examples 1-16 demonstrate, surfactant choice has a significant impact on solubilization capacity, and thus on partially soluble agent concentration and in vivo deposition. Knowledge of this relationship led to the discovery that certain surfactant types are more advantageous than others for achieving high partially soluble agent concentrations. Even when the soluble active concentration is fixed at 1 wt. % and the surfactant concentration is fixed at 15 wt. %, surfactant choice can surprisingly influence achievement of surfactant-soluble agent deposition targets. Even when the active and surfactant concentrations are fixed, surfactant choice significantly impacts deposition, reaching 1.7 μg / cm in this example alone. 2 to 3.0 μg / cm 2 The present invention is directed to surfactants that allow for higher surfactant-soluble agent deposition targets by including partial soluble agent concentrations of about 0.5-1.0, about 0.6-1.0, and about 0.75-1.

[0227] The dimensions and values ​​disclosed herein should not be understood as being strictly limited to the exact numerical values ​​recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as "40 mm" is intended to mean "approximately 40 mm."

[0228] All documents cited in this application, including any cross-referenced or related patents or patent applications, and any patent applications or patents to which this application claims priority or benefit, are incorporated herein by reference in their entirety, unless expressly stated to the contrary. The citation of any document shall not be deemed to be prior art to any invention disclosed or claimed herein, or to teach, suggest, or disclose such invention, either alone or in combination with any other reference(s). Furthermore, to the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition assigned to that term in this document shall govern.

[0229] While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention. Exemplary embodiments of the present invention are set forth below. (1) A hair care composition comprising: a) 8% to 25% of one or more surfactants; b) 0.01% to 10% of one or more surfactant-soluble agents; c) the composition has a partial solubilizer concentration (α) of 0.5 to 1.0, where "α" is

number

Claims

1. 1. A hair care composition comprising: a) 8% to 25% of one or more anionic surfactants, including amino acid-based anionic surfactants; b) 0.01% to 10% of one or more surfactant-soluble agents, wherein the surfactant-soluble agent is piroctone olamine; c) the composition has a partial solubility agent concentration (α) of 0.75 to 1.0, where "α" is [Equation 1] where C is the concentration (w / w%) of the surfactant-soluble agent in the hair care composition; s i is the surfactant concentration (w / w%) in the hair care composition, and K s i is the concentration (ppm) of the surfactant-soluble agent that can be dissolved in a 1% by weight solution of the surfactant in citrate phosphate buffer solution at pH 5.5, A hair care composition having a surfactant concentration to surfactant-soluble active concentration of 15:1 by weight.

2. 10. The hair care composition of claim 1, wherein the surfactant-soluble agent is from 0.2% to 3% by weight.

3. 3. The hair care composition of claim 1 or 2, further comprising one or more scalp health agents.

4. 4. The hair care composition of claim 1, wherein the anionic surfactant is present in an amount of from 8% to 17% by weight.

5. The anionic surfactants include sodium lauryl sulfate, sodium laureth-n sulfate where n is 0.5 to 3.5, sodium C10-15 alkyl sulfate where the alkyl chain may be straight or branched, sodium C10-15 pareth-n sulfate where n is 0.5 to 3.5 and the alkyl chain may be straight or branched, sodium decyl sulfate, sodium deceth-n sulfate where n is 0.5 to 3.5, sodium undecyl sulfate, sodium undeceth-n sulfate where n is 0.5 to 3.5, sodium tridecyl sulfate, and sodium trideceth-n sulfate where n is 0.5 to 3.5, a) R1O(CH2CHR3O)ySO3M, b) CH3(CH2)zCHR2CH2O(CH2CHR3O)ySO3M, and c) Mixtures of these wherein R1 represents CH3(CH2)10, R2 represents H or a hydrocarbon radical containing 1 to 4 carbon atoms such that the sum of the carbon atoms in z and R2 is 8, R3 is H or CH3, y is 0 to 7, and when y is not zero (0), the average value of y is 1, and M is a monovalent or divalent positively charged cation.

5. The hair care composition of claim 1, which is an anionic surfactant blend comprising an anionic surfactant selected from the group consisting of:

6. 6. The hair care composition according to claim 1, wherein the anionic surfactant is an anionic surfactant blend comprising a surfactant selected from the group consisting of amino acid-based anionic surfactants.

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