Anti-inflammatory ingredients

Abstract

The present invention relates to a personal composition comprising a) a strobilurin and b) salicylic acid, in a ratio of a:b of about 1:1 to about 100:1, and having synergistic anti-inflammatory / cellular stress activity.

Description

[Technical Field]

[0001] The present invention relates to personal care compositions comprising strobilurins and salicylic acid that demonstrate synergistic anti-inflammatory activity. [Background technology]

[0002] Optimal hair, scalp, and skin health depends on the control of cellular stress and the ability to counteract or eliminate damage through appropriate protective mechanisms. Cellular stress can be induced by reactive oxygen species, pollution, toxins, microorganisms, mechanical or chemical damage, and several other exogenous or endogenous factors. Prolonged, unresolved or high levels of cellular stress manifest as a decline in hair, scalp, and skin health, accompanied by visible signs of damage (e.g., hair loss, loss of hair and skin pigmentation, dry scalp or skin, flaking, itching, etc.) and both accelerated and natural aging. Cellular responses to pathological stress converge on inflammation as a major and common mechanism, and excessive inflammation contributes to declines in health and some stress-related diseases. Chronic inflammatory skin disorders, such as dandruff and acne, are widespread and both involve microorganisms on the skin that produce substances that induce and exacerbate inflammation. Summary of the Invention [Problem to be solved by the invention]

[0003] There is a need for improved products to address and resolve inflammation and cellular stress in chronic skin, scalp, and hair disorders. There is also a need for personal care products that reduce cellular stress, providing consumers with healthier hair, scalp, and skin, and enhanced anti-aging benefits. [Means for solving the problem]

[0004] The present invention is care The composition of the personal information careThe composition comprises a) a strobilurin and b) salicylic acid, the ratio of a:b being from about 1:1 to about 100:1, and has synergistic anti-inflammatory / cellular stress activity. DETAILED DESCRIPTION OF THE INVENTION

[0005] Unless otherwise specified, all percentages and ratios used herein are by weight of the total composition. Unless otherwise specified, it is understood that all measurements are made at ambient conditions, where "ambient conditions" means conditions at about 25°C, under about 1 atmosphere, and at about 50% relative humidity. All numerical ranges are inclusive of narrower ranges. The stated upper and lower range limits are combinable to create additional ranges not expressly stated.

[0006] The compositions of the present invention can comprise, consist essentially of, or consist of the essential and optional ingredients described herein. As used herein, "consisting essentially of" means that the composition or component may include additional ingredients, but only if the additional ingredients do not materially alter the basic and novel characteristics of the claimed composition or method.

[0007] As used herein, "comprising" means that other steps and other ingredients that do not affect the end result can be added. This term encompasses the terms "consisting of" and "consisting essentially of."

[0008] As used herein, "mixture" is meant to include simple combinations of substances and any compounds that may result from those combinations.

[0009] As used herein, "molecular weight" refers to weight average molecular weight, unless otherwise specified. Molecular weight is measured using gel permeation chromatography ("GPC"), an industry standard method.

[0010] When amount ranges are given, they should be understood to be the total amount of that ingredient in the composition, or, if more than one ingredient falls within the range of an ingredient definition, the total amount of all ingredients fitting that definition in the composition.

[0011] All percentages, parts and ratios are by weight based on the total weight of the compositions of the present invention unless otherwise specified. All such weights as they pertain to listed ingredients are based on the active level and, therefore, do not include carriers or by-products that may be included in commercially available materials.

[0012] Unless otherwise noted, all component or composition levels refer to the active portion of that component or composition and exclude impurities, e.g., residual solvents or by-products, that may be present in commercial sources of such component or composition.

[0013] It should be understood that every maximum numerical limitation given throughout this specification includes every lower numerical limitation, as if such lower numerical limitations were expressly written herein. Every minimum numerical limitation given throughout this specification will include every higher numerical limitation, as if such higher numerical limitations were expressly written herein. Every numerical range given throughout this specification will include every narrower numerical range that falls within such broader numerical range, as if such narrower numerical ranges were all expressly written herein.

[0014] Strobilurin compounds Strobilurins are a general class of compounds used as agricultural fungicides derived from natural fungal metabolites. They are either naturally biosynthesized by various basidiomycete fungi, such as Strobilurus tenacellus and Oudemansiella mucida, or they are modeled after natural strobilurins, retaining the primary β-methoxyacrylate toxophore. Some synthetic strobilurins contain modified toxophores, such as methyl methoxyiminoacetate or methyl-N-methoxycarbamate. Some synthetic strobilurin compounds are azoxystrobin (CAS number: 131860-33-8), cumoxystrobin (CAS number: 850881-70-8), dimoxystrobin (CAS number: 149961-52-4), enoxastrobin (CAS number: 238410-11-2), fluoxastrobin (CAS number: 193740-76-0), kresoxim-methyl (CAS number: 143390-89-0), and mandestrobin. These are strobin (CAS number 173662-97-0), metominostrobin (CAS number 133408-50-1), orysastrobin (CAS number 248593-16-0), picoxystrobin (CAS number 117428-22-5), pyraclostrobin (CAS number 175013-18-0), pyraoxystrobin (CAS number 862588-11-2), and trifloxystrobin (CAS number 141517-21-7).

[0015] Strobilurin compounds control a wide range of plant fungal diseases and are widely used in crop protection worldwide. They act by inhibiting fungal growth through the inhibition of mitochondrial respiration. Their specific mechanism of action is by binding to the ubiquinol oxidation site (Q0 site) of cytochrome b complex III in the electron transport chain, inhibiting electron transfer between cytochrome b and cytochrome c1. Other compounds with this mechanism of action include synthetic and naturally occurring derivatives of the major β-methoxyacrylate toxin known as oudemansins, first isolated from Oudemansiella mucida; synthetic and naturally occurring myxothiazoles from myxobacteria such as Myxococcus flavus; stigmatellin from myxobacteria such as Stigmatella aurantica; and the synthetic pesticides famoxadone and fenamidone.

[0016] Azoxystrobin is an example of an agricultural fungicide that belongs to the class of strobilurin compounds. As an agricultural fungicide, azoxystrobin has protectant, curative, exterminating, translaminar and systemic effects, inhibits spore germination and mycelial growth, and also exhibits antisporogenic activity. At the labeled application rate, azoxystrobin effectively controls numerous plant pathogens, including Erysiphe graminis, Puccinia spp., Lepiosphaeria nodorum, Septoria tritici, and Pyrenophora teres in temperate cereals; Pyricularia oryzae and Rhizoctonia solani in rice; Plasmopara viticola and Uncinula necator in grapevines; Sphaerotheca fuliginea and Pseudoperonospora cubensis in cucurbits; Phytophthora infestans and Alternaria solani in potato and tomato; Mycosphaerella arachidis, Rhizoctonia solani, and Sclerotium rolfsii in peanut; Monilinia spp. and Cladosporium carpophilum in peach; Pythium spp. and Rhizoctonia solani in turf; and Mycosphaerella in bananas. spp.; Cladosporium caryigenum on pecan; Elsinoe fawcetii, Colletotrichum spp. and Guignardia citricarpa on citrus; Colletotrichum spp. and Hemileia vastatrix on coffee. Azoxystrobin is a solid substance with low solubility in water.

[0017] Trade names for azoxystrobin include ABOUND FLOWABLE FUNGICIDE, Aframe, Azoxystar, Azoxyzone, AZteroid 1.65 SC Fungicide, AZURE AGRICULTURAL FUNGICIDE, Endow, QUADRIS FLOWABLE FUNGICIDE, Satori Fungicide, Strobe 2L, and Willowood Azoxy 2SC. Azoxystrobin is commercially available from, for example, Sigma-Aldrich (St. Louis, MO) and Ak Scientific, Inc. (Union City, CA).

[0018] In the present invention, the personal care composition may include from about 0.02% to about 10% azoxystrobin, from about 0.05% to about 2% azoxystrobin, or from about 0.1% to about 1% azoxystrobin.

[0019] In the present invention, the personal care composition may comprise from about 0.02% to about 10% of a strobilurin, from about 0.05% to about 2% of a strobilurin, or from about 0.1% to about 1% of a strobilurin.

[0020] Salicylic acid The salicylic acid suitable for use in the present invention includes salicylic acid or its salt. In the present invention, such salicylic acid salts may include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, ammonium salts, and trialkylammonium salts such as trimethylammonium and triethylammonium. The present invention also includes capryloyl salicylic acid, methyl salicylate, acetylsalicylate, sodium salicylate, choline salicylate, methyl salicylic acid, acetylsalicylic acid, aminosalicylic acid, salicylsalicylic acid, menthyl salicylate, phenyl salicylate, amyl salicylate, octyl salicylate, benzyl salicylate, glyceryl salicylate, salicin, salicylaldehyde, salicortin, 2'- These may include 0-acetylsalicortin, (-)-tremulacin, saligenin, diflunisal, fendosal, butyloctyl salicylate, C12-15 alkyl salicylates, hexyldodecyl salicylate, isocetyl salicylate, isodecyl salicylate, monoethanolamine salicylate, ethylhexyl salicylate, myristyl salicylate, trolamine salicylate, and tridecyl salicylate. The present invention may also include salicylates in the form of natural products such as oil of hollyhock and extract of pine bark.

[0021] In the present invention, the personal care composition may contain from about 0.1% to about 10% salicylic acid, the hair care composition may contain from about 0.3% to about 3% salicylic acid, and the hair care composition may contain from about 0.5% to about 2% salicylic acid.

[0022] Other antibacterial active substances The present invention may include scalp health agents selected from polyvalent metal salts of pyrithione and may further include one or more antifungal or antibacterial actives. Suitable antibacterial actives include 2-pyridinol-N-oxide materials, which may include substituted or unsubstituted 2-pyridinol-N-oxide materials or salts thereof. Tautomers of this material, such as 1-hydroxy-2(1H)-pyridinone, are included within the scope of the present invention, as are other compounds such as piroctone olamine, coal tar, sulfur, Whitfield's ointment, Castellani liniment, aluminum chloride, gentian violet, ciclopirox olamine, undecylenic acid and its metal salts, potassium permanganate, selenium sulfide, sodium thiosulfate, propylene glycol, bitter orange oil, urea preparations, griseofulvin, 8-hydroxyquinoline, clioquinol, thiobendazole, thiocarbamate, haloprogin, polyenes, hydroxypyridone, morpholine, benzylamine, allylamines (e.g., terbinafine), tea tree oil, neem, clove leaf oil, coriander, palmarosa, berberine, thyme red, cinnamon bark oil, cinnamaldehyde, citronellic acid, hinokitiol, ichthyol pale, Sensiva SC-50, and Elestab. These include HP-100, azelaic acid, lyticase, iodopropynyl butylcarbamate (IPBC), isothiazarinones and azoles such as octylisothiazarinone, and combinations thereof. The present invention may include antibacterial agents such as itraconazole, ketoconazole, selenium sulfide, and coal tar.

[0023] b. Selenium sulfide Selenium sulfide is a suitable particulate scalp health agent for use in the antimicrobial compositions of the present invention. Selenium sulfide is generally considered to be a compound having one mole of selenium and two moles of sulfur, but has the general formula Se x S yThe selenium sulfide may have a cyclic structure conforming to the formula (where x+y=8). The average particle size of selenium sulfide, as measured by a forward laser light scattering device (e.g., a Malvern 3600 instrument), is typically less than 15 μm, and in the present invention may be less than 10 μm. Selenium sulfide compounds are described, for example, in U.S. Pat. Nos. 2,694,668, 3,152,046, 4,089,945, and 4,885,107.

[0024] c. Sulfur Sulfur may also be used as a particulate antimicrobial / scalp health agent in the antimicrobial compositions of the present invention.

[0025] Additional antibacterial active substances Additional antimicrobial actives of the present invention may include extracts of melaleuca (tea tree) and charcoal. The present invention may also include combinations of antimicrobial actives. Such combinations may include piroctone olamine and zinc pyrithione, pine tar and sulfur, salicylic acid and zinc pyrithione, piroctone olamine and climbazole, and salicylic acid and piroctone olamine, zinc pyrithione and climbazole, and mixtures thereof.

[0026] In the present invention, the scalp health agent may be present in an amount of about 0.01% to 10%, about 0.1% to 9%, about 0.25% to 8%, or about 0.5% to 6%.

[0027] In the present invention, the composition includes an effective amount of a zinc-containing layered material. The zinc-containing layered material may be one in which crystal growth occurs primarily in two dimensions. It is customary to describe the layered structure not only as one in which all atoms are incorporated into well-defined layers, but also as one in which there are ions or molecules between the layers, called gallery ions (A.F. Wells, "Structural Inorganic Chemistry," Clarendon Press, 1975). A zinc-containing layered material (ZLM) may incorporate zinc into the layers and / or may be a component of the gallery ions. The following classifications of ZLMs represent relatively general examples of general categories and are not intended to be limiting with respect to the broader range of materials that fit this definition.

[0028] Many ZLMs occur naturally as minerals. In the present invention, the ZLM may be selected from the group consisting of hydrozincate (zinc carbonate hydroxide), basic zinc carbonate, hydrozincate (zinc copper carbonate hydroxide), zinc malachite (zinc copper carbonate hydroxide), and mixtures thereof. Related minerals containing zinc may also be included in the composition. Natural ZLMs may also exist in which anionic layer species, such as clay minerals (e.g., phyllosilicates), contain ion-exchanged zinc gallery ions. All of these natural materials may be synthetically obtained or formed in situ in the composition or during the manufacturing process.

[0029] Another general class of ZLMs, which are often, but not always, synthetic, are layered double hydroxides. In the present invention, ZLMs are those having the formula [M 2+ 1-x M 3+ x (OH)2] x+ A m- x / m nH2O (wherein divalent ions (M 2+) may be a layered double hydroxide conforming to (Crepaldi, EL, Pava, PC, Tronto, J, Valim, JB J. Colloid Interfac. Sci. 2002, 248, 429-42), in which some or all of the ions are zinc ions.

[0030] Another class of ZLMs, called hydroxy double salts, can also be prepared (Morioka, H., Tagaya, H., Karasu, M., Kadokawa, J., Chiba, K. Inorg. Chem. 1999, 38, 4211-6). In the present invention, ZLMs are those having the formula [M 2+ 1-x M 2+ 1+x (OH) 3(1-y) ] + A n- (1=3y) / n nH2O (wherein two metal ions (M 2+ ) may be the same or different) and may be a hydroxy double salt corresponding to ). When the metal ion is the same and is represented by zinc, the formula is simplified to [Zn 1+x (OH)2] 2x+ 2x A - ·nH2O. This latter formula represents materials such as zinc hydroxychloride and zinc hydroxynitrate (where x=0.4). In the present invention, ZLM can be zinc hydroxychloride and / or zinc hydroxynitrate. This also relates to zinc hydroxylates in which a divalent anion replaces a monovalent anion. These materials can also be formed in situ in the composition or during the manufacturing process.

[0031] In the present invention, the composition may contain basic zinc carbonate. Commercial sources of basic zinc carbonate include basic zinc carbonate (Cater Chemicals, Bensenville, IL, USA), zinc carbonate (Shepherd Chemicals, Norwood, OH, USA), zinc carbonate (CPS Union Corp., New York, NY, USA), zinc carbonate (Elementis Pigments, Durham, UK), and zinc carbonate AC (Bruggemann Chemical, Newtown Square, PA, USA). Basic zinc carbonate, sometimes commercially referred to as "zinc carbonate," "zinc carbonate base," or "zinc hydroxycarbonate," is a synthetic product made from materials similar to natural zinc oxide. While the ideal stoichiometry is represented by Zn5(OH)6(CO3)2, the actual stoichiometric ratio may vary slightly, and other impurities may be incorporated into the crystal lattice.

[0032] In the present invention, the composition may comprise an effective amount of zinc-containing layered material, such as from about 0.001% to about 10%, or from about 0.01% to about 7%, or from about 0.1% to about 5% of the zinc-containing layered material by total weight of the composition.

[0033] The present invention may comprise a zinc-containing layered material and pyrithione or a polyvalent metal salt of pyrithione, wherein the ratio of zinc-containing layered material to pyrithione or a polyvalent metal salt of pyrithione is from about 5:100 to about 10:1, or from about 2:10 to about 5:1, or from about 1:2 to about 3:1.

[0034] PGE-2 assay Inhibition of cellular inflammatory responses to stressors—Prostaglandin E2 (“PGE2”) assay.

[0035] This example demonstrates the ability of a combination of a strobilurin compound and salicylic acid at a certain ratio to synergistically inhibit the activation of PGE2. PGE2 is a hormone-like substance known to be involved in regulating inflammation. Because cellular inflammation is associated with various hair, skin, and scalp conditions, inhibiting the activation of PGE2 in response to cellular inflammation may be useful in treating these types of hair, skin, and scalp conditions.

[0036] method TERT keratinocytes ("TERT keratinocyte, tKC" - tKC are human keratinocytes transfected with the human telomerase reverse transcriptase gene to immortalize the cells) are obtained from Jerry Shay, University of Texas, Southwestern, and seeded at 40,000 cells / well in 24-well plates in a volume of 1 ml / well. EpiLife Medium (Life Technologies catalog number MEPICFPRF 500) supplemented with keratinocyte growth supplement (Life technologies catalog number S-001-5) is used as the assay medium. Cells are grown to confluence / near confluence (typically 24 hours after plating 40,000 cells / well in a 24-well plate) and then irradiated with 15 mJ / cm. 2The plates are subjected to UVB stress (typically 14-16 irradiation times in BioSun). Test compositions (strobilurins, salicylic acid, strobilurins + salicylic acid, and the positive control 10 μM idebenone) are added to replace the medium (EpiLife medium containing a final concentration of 0.1% DMSO - briefly, 1000x stocks of active and combination substances are made in 100% DMSO and diluted 1:1000 in EpiLife medium), and the plates are incubated for 18-24 h. The supernatant is removed from each well, and the cells are rinsed with 2 mL / well of medium (without supplements). ATP activity is measured using the Cell Titer-Glo assay (Promega catalog number G7571; Madison, WI) and normalized to the cells. The supernatant is tested in a PGE2 assay (Cisbio Bioassays Prostaglandin E2 Assay Kit catalog number 62P2APEB) according to the manufacturer's instructions. PGE2 results are normalized to ATP activity by dividing the PGE2 quantification (pg / mL) from the supernatant by the normalization factor (treated ATP / control ATP).

[0037] Example calculation for calculating PGE2 inhibition by strobilurins: Luminescence of vehicle control in ATP assay = 704567 Luminescence of strobilurin treatment in ATP assay = 678903 Normalization factor for strobilurin treatment = 1.038 PGE2 determination in vehicle control = 2458 pg / mL PGE2 PGE2 quantification after strobilurin treatment = 2347 pg / mL PGE2 Normalized PGE2 values Control = 2458 / 1 = 2458 Strobilurin = 2347 / 1.038 = 2261 Strobilurin inhibition rate (%) = [100 × (2458 - 2347) / 2458] = 8%

[0038] A Student's t-test (equal variance, two-tailed) was used to calculate the p-value between the observed and expected combinations, with a p-value of <0.05 considered statistically significant. The expected combination value was calculated by adding the PGE2 inhibition values ​​of the strobilurin compound alone and salicylic acid alone. The synergy coefficient is simply the ratio of the observed combination / expected combination. A synergistic effect is considered to exist if the synergy coefficient is greater than 1.0 and the p-value is less than 0.05.

[0039] The conclusion of the PGE2 experiments is that strobilurins and salicylic acid, individually at these levels, are relatively weak agents for inhibiting PGE2 release from keratinocytes, and that the combination of a strobilurin and salicylic acid actually suppresses PGE2 release to a surprising degree. Other strobilurins also synergistically inhibit PGE2 release. To define the ratio at which synergistic inhibition of PGE2 release occurs, multiple ratios of azoxystrobin to salicylic acid were tested, with statistically significant synergy at 1:1 and 50:1 azoxystrobin:salicylic acid ratios. Although statistically significant synergy is not observed at 1:10 and 100:1 azoxystrobin:salicylic acid ratios, the combination does indeed demonstrate additivity in reducing PGE2 release at these ratios.

[0040] In the present invention, it can be demonstrated that the combination of another strobilurin and salicylic acid actually surprisingly synergistically inhibits PGE2 release as well. Synergistic inhibition of PGE2 release occurs with the combinations of trifloxystrobin and salicylic acid at 50:1, orysastrobin and salicylic acid at 1:1 to 50:1, kresoxim-methyl and salicylic acid at 50:1, dimoxystrobin and salicylic acid at 50:1, fluoxastrobin and salicylic acid at 10:1 and 50:1, and picoxystrobin and salicylic acid at 10:1 to 100:1.

[0041] [Table 1-1]

[0042] [Table 1-2] * indicates statistical significance (p-value between observed and expected values ​​<0.05).

[0043] The table above includes a range of strobilurin compounds, including salicylic acid.

[0044] [Table 2]

[0045] In the present invention, personal care The composition may comprise a) a strobilurin and b) salicylic acid, where the ratio of a:b is about 1:1 to about 100:1, and has synergistic anti-inflammatory / cellular stress activity. The invention may include methods of using a composition comprising a) a strobilurin and b) salicylic acid, where the ratio of a:b is about 1:1 to about 100:1, and provides synergistic anti-inflammatory / cellular stress activity. The invention may include methods of using a composition comprising a) a strobilurin and b) salicylic acid, where the ratio of a:b is about 1:1 to about 100:1, and provides synergistic anti-inflammatory / cellular stress activity, reducing PGE2 release by at least about 20% compared to baseline. The invention may include methods of reducing PGE2 release by at least about 40% compared to baseline. The invention may include the use of a strobilurin compound and salicylic acid in a personal care composition to improve inflammatory and cellular stress conditions in the skin, scalp, and hair. The present invention may involve the use of strobilurin compounds and salicylic acid in personal care compositions for anti-inflammatory benefits.

[0046] Detergent surfactants The present invention may be in the form of a shampoo, conditioner, or leave-on treatment. The shampoo composition may contain one or more detersive surfactants that provide cleaning performance to the composition. The one or more detersive surfactants may further include anionic surfactants, amphoteric surfactants, zwitterionic surfactants, or mixtures thereof. Various examples and descriptions of detersive surfactants are described in U.S. Patent No. 6,649,155, U.S. Patent Application Publication Nos. 2008 / 0317698 and 2008 / 0206355, which are incorporated herein by reference in their entireties.

[0047] The concentration of the detersive surfactant component in the shampoo composition should be sufficient to provide the desired cleaning and foaming performance, and generally ranges from about 2% to about 50% by weight, from about 5% to about 30% by weight, from about 8% to about 25% by weight, from about 10% to about 20% by weight, about 5% by weight, about 10% by weight, about 12% by weight, about 15% by weight, about 17% by weight, about 18% by weight, or about 20% by weight.

[0048] Suitable anionic surfactants for use in the present composition are alkyl and alkyl ether sulfates.Other suitable anionic surfactants are water-soluble salts of organic sulfuric acid reaction products.Still other suitable anionic surfactants are the reaction products of fatty acids esterified with isethionic acid and neutralized with sodium hydroxide.Other similar anionic surfactants are described in U.S. Patent Nos. 2,486,921, 2,486,922, and 2,396,278, which are incorporated herein by reference in their entirety.

[0049] Representative anionic surfactants for use in shampoo compositions include ammonium lauryl sulfate, ammonium laureth sulfate, triethylamine lauryl sulfate, triethylamine laureth sulfate, triethanolamine lauryl sulfate, triethanolamine laureth sulfate, monoethanolamine lauryl sulfate, monoethanolamine laureth sulfate, diethanolamine lauryl sulfate, diethanolamine laureth sulfate, lauryl monoglyceride sodium sulfate, sodium lauryl sulfate, sodium laureth sulfate, potassium lauryl sulfate, potassium laureth sulfate, sodium lauryl sarcosinate, sodium lauroyl sarcosinate, lauryl sarcosine, cocoyl sarcosine, ammonium cocoyl sulfate, ammonium lauroyl sulfate, sodium cocoyl sulfate, sodium lauroyl sulfate, potassium cocoyl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, triethanolamine lauryl sulfate, monoethanolamine cocoyl sulfate, monoethanolamine lauryl sulfate, sodium tridecylbenzenesulfonate, sodium dodecylbenzenesulfonate, sodium cocoyl isethionate, and combinations thereof. The anionic surfactant may be sodium lauryl sulfate or sodium laureth sulfate.

[0050] Suitable amphoteric or zwitterionic surfactants for use in the shampoo compositions herein include those known for use in shampoos or other personal care cleansers. Concentrations of such amphoteric surfactants range from about 0.5% to about 20% by weight, and from about 1% to about 10% by weight. Non-limiting examples of suitable zwitterionic or amphoteric surfactants are described in U.S. Patent Nos. 5,104,646 and 5,106,609, which are incorporated herein by reference in their entireties.

[0051] Amphoteric detersive surfactants suitable for use in shampoo compositions include surfactants broadly described as derivatives of aliphatic secondary and tertiary amines, where the aliphatic group can be straight or branched, one of the aliphatic substituents having from about 8 to about 18 carbon atoms, and one containing an anionic group such as carboxy, sulfonate, sulfate, phosphate, or phosphonate. Exemplary amphoteric detersive surfactants for use in shampoo compositions of the present invention include cocoamphoacetate, cocoamphodiacetate, lauroamphoacetate, lauroamphodiacetate, and mixtures thereof.

[0052] Zwitterionic detersive surfactants suitable for use in shampoo compositions include surfactants broadly described as derivatives of aliphatic quaternary ammonium, phosphonium, and sulfonium compounds, where the aliphatic groups can be straight or branched, one of the aliphatic substituents having from about 8 to about 18 carbon atoms, and one containing an anionic group, such as carboxy, sulfonate, sulfate, phosphate, or phosphonate. Additionally, zwitterionics such as betaines can be selected.

[0053] Non-limiting examples of other anionic, zwitterionic, amphoteric, or optional additional surfactants suitable for use in shampoo compositions are described in McCutcheon "Emulsifiers and Detergents, 1989 Annual" (published by MC Publishing Co.), as well as U.S. Pat. Nos. 3,929,678, 2,658,072, 2,438,091, and 2,528,378, which are incorporated herein by reference in their entireties.

[0054] The shampoo composition may also include a shampoo gel matrix, an aqueous carrier, and other additional ingredients as described herein.

[0055] Water-based carrier Shampoo compositions include a first aqueous carrier. Shampoo composition formulations may therefore be in the form of a pourable liquid (under ambient conditions). Such compositions therefore typically include a first aqueous carrier, which is present in a concentration of at least 20% by weight, from about 20% to about 95% by weight, or from about 60% to about 85% by weight. The first aqueous carrier may comprise water or a compatible mixture of water and an organic solvent, although in one embodiment, the first aqueous carrier may comprise water with minimal or no significant concentrations of organic solvent, except when incidentally incorporated into the composition as a minor component of other components.

[0056] First aqueous carriers useful in shampoo compositions include water and aqueous solutions of lower alkyl alcohols and polyhydric alcohols. Lower alkyl alcohols useful herein are monohydric alcohols having 1 to 6 carbon atoms, in one embodiment, ethanol and isopropanol. Polyhydric alcohols useful herein include propylene glycol, hexylene glycol, glycerin, and propanediol.

[0057] A. Aqueous Carrier The conditioner gel matrix of the conditioner composition includes a second aqueous carrier. Thus, the conditioner composition formulation may be in the form of a pourable liquid (under ambient conditions). Accordingly, such compositions typically include a second aqueous carrier, which is present in a concentration of about 20% to about 95% by weight, or about 60% to about 85% by weight. The second aqueous carrier may include water or a compatible mixture of water and an organic solvent, but in one embodiment, may include water with minimal or no significant concentrations of organic solvent, except when incidentally incorporated into the composition as a minor component of other components.

[0058] Secondary aqueous carriers useful in the conditioner composition include water and aqueous solutions of lower alkyl alcohols and polyhydric alcohols. The lower alkyl alcohols useful herein are monohydric alcohols having 1 to 6 carbon atoms, in one embodiment, ethanol and isopropanol. The polyhydric alcohols useful herein include propylene glycol, hexylene glycol, glycerin, and propanediol.

[0059] Additional ingredients The shampoo compositions, conditioner compositions, and / or leave-on treatments described herein may contain one or more additional ingredients known for use in hair care or personal care products, so long as the additional ingredients are physically and chemically compatible with the essential ingredients described herein and do not unduly impair the product's stability, aesthetics, or performance. Such additional ingredients are most typically those described in references such as CTFA Cosmetic Ingredient Handbook, Second Edition, The Cosmetic, Toiletries, and Fragrance Association, Inc. 1988, 1992. The individual concentration of such additional ingredients may range from about 0.001% to about 10% by weight of the hair care composition.

[0060] Non-limiting examples of additional ingredients for use in hair care compositions include conditioning agents, natural cationic deposition polymers, synthetic cationic deposition polymers, antidandruff agents, particles, suspending agents, paraffinic hydrocarbons, propellants, viscosity modifiers, dyes, non-volatile solvents or diluents (water soluble and water insoluble), pearlizing aids, foaming agents, additional surfactants or nonionic co-surfactants, pediculicides, pH adjusters, fragrances, preservatives, proteins, skin active agents, sunscreens, UV absorbers, and vitamins.

[0061] 1. Conditioning agent Hair care compositions may contain one or more conditioning agents.Conditioning agents include materials that are used to provide specific conditioning effects to hair.Conditioning agents useful in the hair care compositions of the present invention typically comprise non-water-soluble, water-dispersible, non-volatile liquids that form emulsified liquid particles.Conditioning agents suitable for use in hair care compositions are generally those characterized by silicone, organic conditioning oil, or a combination thereof, or those that form liquid dispersed particles in an aqueous surfactant matrix by other methods.

[0062] The one or more conditioning agents are present from about 0.01% to about 10%, from about 0.1% to about 8%, and from about 0.2% to about 4% by weight of the composition.

[0063] Silicone Conditioning Agent The compositions of the present invention may contain one or more silicone conditioning agents. Examples of silicones include dimethicone, dimethiconol, cyclic silicones, methylphenylpolysiloxane, and modified silicones with various functional groups, such as amino groups, quaternary ammonium salt groups, aliphatic groups, alcohol groups, carboxylic acid groups, ether groups, epoxy groups, sugar or polysaccharide groups, fluorine-modified alkyl groups, alkoxy groups, or combinations of such groups. Such silicones may be soluble or insoluble in aqueous (or non-aqueous) product carriers. In the case of insoluble liquid silicones, the polymer may be in an emulsified form with droplet sizes of about 10 nm to about 30 micrometers.

[0064] Organic Conditioning Materials The conditioning agent of the compositions of the present invention may also include at least one organic conditioning material, such as an oil or wax, either alone or in combination with other conditioning agents, such as the silicones described above. The organic material may be non-polymeric, oligomeric, or polymeric. It may be in the form of an oil or wax and may be added to the formulation neat or in a pre-emulsified form. Some non-limiting examples of organic conditioning materials include: i) hydrocarbon oils; ii) polyolefins; iii) fatty esters; iv) fluorinated conditioning compounds; v) fatty alcohols; vi) alkyl glucosides and alkyl glucoside derivatives; vii) quaternary ammonium compounds; and viii) polyethylene glycols and polypropylene glycols having a molecular weight of up to about 2,000,000, such as those with the CTFA designations PEG-20 200, PEG-400, PEG-600, PEG-1000, PEG-2M, PEG-7M, PEG-14M, PEG-45M, and mixtures thereof.

[0065] Benefit Agents The hair care composition may further comprise one or more additional benefit agents, including materials selected from the group consisting of anti-dandruff agents, anti-fungal agents, anti-itch agents, anti-fungal agents, anti-bacterial agents, moisturizers, antioxidants, vitamins, fat-soluble vitamins, fragrances, whitening agents, enzymes, sensates, attractants, dyes, pigments, bleaches, and mixtures thereof.

[0066] The hair care composition of the present invention can be present in a typical hair care formulation. This composition can be in the form of a solution, dispersion, emulsion, powder, talc, capsule, sphere, sponge, solid dosage form, foam, and other delivery mechanisms. The composition of the present invention can be in the form of leave-on hair products such as hair tonics, treatment and styling products, rinse-off hair products such as shampoos and treatment products, and any other form that can be applied to hair.

[0067] Hair care compositions are generally prepared by conventional methods, such as those known in the art for producing compositions. Such methods typically involve mixing the ingredients in one or more steps to a relatively homogeneous state, with or without heating, cooling, application of vacuum, etc. The compositions are formulated to optimize stability (physical stability, chemical stability, photostability) and / or delivery of actives. The hair care composition may be present in a single phase or product, or the hair care composition may be present in separate phases or separate products. When two products are used, the products may be used together, simultaneously, or sequentially. Sequential use may occur within a short period of time, such as immediately after use of one product, or over a period of several hours or days.

[0068] The present invention may relate to the use of strobilurin compounds in personal care compositions to improve inflammatory and cellular stress conditions in the skin, scalp, and hair. The present invention may relate to the use of strobilurin compounds in personal care compositions for anti-inflammatory benefit. The present invention may relate to the use of strobilurin compounds as claimed in the present invention for anti-inflammatory benefit. [Example]

[0069] Non-limiting examples The shampoo compositions illustrated in the following examples are prepared by conventional formulation and mixing methods. All exemplified amounts are listed as weight percentages on an active basis and exclude minor materials such as diluents, preservatives, etc., and color percentages are by weight unless otherwise specified.

[0070] [Table 3]

[0071] All figures above are based on activity. For example, for 11% SLE1S, 44% of a 25% active SLE1S solution should be added. The table below explains each of the notes in the table above.

[0072] [Table 4]

[0073] The following examples further describe and demonstrate embodiments within the scope of the present invention. These examples are provided for illustrative purposes only and should not be construed as limiting the invention, as many variations thereof are possible without departing from the spirit and scope of the invention. Where applicable, ingredients are identified by chemical name or CTFA name, or as otherwise defined below.

[0074] [Table 5]

[0075] [Table 6] 1 Pride Solvents SD-40B 200 Alcohol 2 Ashland Flexithix 3 Ashland Benecel K200M 4 Structure XL by AkzoNobel 5 Menthol by Kerry Ingredients and Flavors 6. Salicylic Acid manufactured by Ampak Company 7. Lonza Niacinamide 8. Caffeine from Merck 9. D-Panthenol manufactured by BASF 10 BASF Cremophor RH-40 11 Propylene glycol from Sigma Aldrich

[0076] combination Paragraph A. Personal care 1. A composition comprising: a) strobilurins; b) salicylic acid, The ratio of a:b is about 1:1 to about 100:1, and has synergistic anti-inflammatory / cell stress activity. care composition. Paragraph B. The personal care composition of Paragraph A, wherein the anti-inflammatory benefit is measured as prostaglandin E2 (PGE2) activity. Paragraph C. The personal care composition of paragraph A or B, wherein the strobilurin is selected from the group consisting of azoxystrobin, trifloxystrobin, orysastrobin, kresoxim-methyl, dimoxystrobin, fluoxastrobin, picoxystrobin, and mixtures thereof. Paragraph D. The personal care composition of any one of Paragraphs A to C, wherein the ratio of azoxystrobin:salicylic acid is from about 1:1 to about 50:1. Paragraph E The personal care composition of any one of Paragraphs AD, wherein the ratio of trifloxystrobin:salicylic acid is about 50:1. Paragraph F. The personal care composition of any one of Paragraphs A through E, wherein the ratio of orysastrobin:salicylic acid is from about 1:1 to about 50:1. Paragraph G The personal care composition of any one of Paragraphs A-F, wherein the ratio of kresoxim methyl:salicylic acid is about 50:1. Paragraph H The personal care composition of any one of Paragraphs A-G, wherein the ratio of dimoxystrobin:salicylic acid is about 50:1. Paragraph I. The personal care composition of any one of Paragraphs AH, wherein the ratio of fluoxastrobin:salicylic acid is from about 10:1 to about 50:1. Paragraph J. The personal care composition of any one of Paragraphs AI, wherein the ratio of picoxystrobin to salicylic acid is from about 10:1 to about 100:1. The personal care composition of any one of Paragraphs AJ, wherein the personal care composition is selected from the group consisting of shampoos, conditioners, leave-ons, tonics, and mixtures thereof. Paragraph L. The personal care composition of any one of Paragraphs A through K, wherein the strobilurin is from about 0.02% to about 10%. Paragraph M The personal care composition of any one of Paragraphs A through L, wherein the salicylic acid is from about 0.1% to about 10% by weight of the composition. The personal care composition of any one of Paragraphs AM, wherein Paragraph N salicylic acid is from 0.5% to about 2% by weight of the composition. Paragraph O. A method of using a composition of any one of Paragraphs A-N, wherein the composition comprises: a) strobilurins; b) salicylic acid, The ratio of a:b is about 1:1 to about 100:1, providing synergistic anti-inflammatory / cell stress activity. Paragraph P: A method of using the composition of any one of paragraphs A-O, wherein the composition: a) strobilurins; b) salicylic acid, The method wherein the ratio of a:b is about 1:1 to about 100:1, providing synergistic anti-inflammatory / cellular stress activity and reducing PGE2 release by at least about 20% compared to baseline. Paragraph Q The method of any one of Paragraphs A-P, wherein PGE2 release is reduced by at least about 40% compared to baseline. Paragraph R. Use of a strobilurin compound according to any one of paragraphs A-Q and salicylic acid in a personal care composition according to claim 1 to improve inflammation and cellular stress conditions in the skin, scalp, and hair. Paragraph S. Use of a strobilurin compound according to any one of paragraphs A-R and salicylic acid in a personal care composition according to claim 1 for anti-inflammatory benefit.

[0077] Product form The personal care compositions of the present invention may be present in typical personal care formulations. The compositions may be in the form of solutions, dispersions, emulsions, powders, talc, capsules, spheres, sponges, solid dosage forms, foams, and other delivery mechanisms. The compositions of the present invention may be in the form of leave-on hair products such as hair tonics, treatment and styling products, rinse-off hair products such as shampoos, pre-wash products, co-wash products, and personal cleansing products, and treatment products, as well as any other form that can be applied to hair or skin.

[0078] The dimensions and values ​​disclosed herein should not be understood as being strictly limited to the exact numerical values ​​recited. Instead, unless otherwise indicated, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as "40 mm" is intended to mean "approximately 40 mm."

[0079] All documents cited herein, including any cross-referenced or related patents or patent applications, and any patent applications or patents to which this application claims priority or benefit, are incorporated herein by reference in their entirety, unless expressly stated to the contrary. The citation of any document shall not be deemed to be prior art to any invention disclosed or claimed herein, or to teach, suggest, or disclose such invention, either alone or in combination with any other reference(s). Furthermore, to the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition assigned to that term in this document shall control.

[0080] While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims

1. 1. A personal care composition comprising: a) a strobilurin, the strobilurin being 0.02% to 10% by weight of the composition; b) salicylic acid, wherein the salicylic acid is 0.1% to 10% by weight of the composition; A personal care composition wherein the weight ratio of a:b is from 1:1 to 100:1, said composition providing synergistic anti-inflammatory / improved cell stress activity.

2. 10. The personal care composition of claim 1, wherein the strobilurin is selected from the group consisting of azoxystrobin, trifloxystrobin, orysastrobin, kresoxim-methyl, dimoxystrobin, fluoxastrobin, picoxystrobin, and mixtures thereof.

3. 3. The personal care composition of claim 2, wherein the weight ratio of azoxystrobin to salicylic acid is from 1:1 to 50:

1.

4. 3. The personal care composition of claim 2, wherein the weight ratio of trifloxystrobin to salicylic acid is 50:

1.

5. 3. The personal care composition of claim 2, wherein the weight ratio of orysastrobin:salicylic acid is from 1:1 to 50:

1.

6. 3. The personal care composition of claim 2, wherein the weight ratio of kresoxim methyl to salicylic acid is 50:

1.

7. 3. The personal care composition of claim 2, wherein the weight ratio of dimoxystrobin to salicylic acid is 50:

1.

8. 3. The personal care composition of claim 2, wherein the weight ratio of fluoxastrobin to salicylic acid is from 10:1 to 50:

1.

9. 3. The personal care composition of claim 2, wherein the weight ratio of picoxystrobin to salicylic acid is from 10:1 to 100:

1.

10. 10. The personal care composition of any one of claims 1 to 9, wherein the personal care composition is selected from the group consisting of shampoos, conditioners, leave-ons, tonics, and mixtures thereof.

11. 11. Use of a strobilurin and salicylic acid in a personal care composition according to any one of claims 1 to 10 to improve inflammation and cellular stress conditions in the skin, scalp and hair.

12. Use of a strobilurin and salicylic acid in a personal care composition according to any one of claims 1 to 10 for anti-inflammatory benefit.

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