Amino Acid Surfactants

Abstract

To provide derivatives of amino acids that have surface-active properties.SOLUTION: Amino acids may be natural or synthetic amino acids, or may be obtained via ring-opening reactions of lactams, e.g., caprolactam. The amino acids may be functionalized to form compounds with surface-active properties and advantageous surfactant properties. The compounds have low critical micelle concentrations (CMCs) and superior ability to lower the surface tension of liquid. The compounds are effective as surface-active agents, and useful for wetting or foaming agents, dispersants, emulsifiers, and detergents, among other applications.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Patent Application No. 62 / 967,170, filed January 29, 2020, the entire disclosure of which is incorporated herein by reference.

[0002] The present disclosure relates to derivatives of amino acids and methods for their synthesis, which amino acid derivatives have surface-active properties. [Background technology]

[0003] Surfactants (molecules with surface-active properties) are an important class of molecules with highly sought-after characteristics. Surfactants can be nonionic, zwitterionic, cationic, or anionic. Often, these compounds are amphiphilic molecules with a water-insoluble hydrophobic "tail" group and a water-soluble hydrophilic "head" group. These compounds can adsorb at interfaces, such as those between two liquids, gas-liquid, or solid-liquid interfaces. In the case of the water-oil interface, the hydrophilic head group extends into the water, while the hydrophobic tail extends into the oil. When added to water, the hydrophilic head group extends into the water, while the hydrophobic tail extends into the air. The presence of surfactants disrupts the intermolecular interactions between water molecules, replacing them with weaker interactions between the water molecules and surfactant. This results in a reduction of surface tension and can also act to stabilize interfaces.

[0004] At sufficiently high concentrations, surfactants can form aggregates that limit the exposure of the hydrophobic tails to polar solvents. One such aggregate is a micelle, where the molecules are arranged in a spherical shape with the hydrophobic tails on the inside of the sphere and the hydrophilic heads on the outside, which interact with polar solvents. The effect that any compound has on surface tension and the concentration at which it forms micelles can be useful characteristics for defining surfactants.

[0005] Surfactants are widely used in commercial applications in a variety of formulations, from detergents to hair care products and cosmetics. Compounds with surface-active properties are used as soaps, detergents, lubricants, wetting agents, foaming agents, and spreading agents, among others. Therefore, there is a continuing need to identify and synthesize such compounds.

[0006] However, it can be difficult to predict whether any compound will have surface-active properties from its structure alone, let alone other important characteristics such as interfacial adsorption kinetics, minimum achievable surface tension, and / or ability to wet hydrophobic and / or lipophilic surfaces, which are also essential for whether a compound will be a useful surfactant. For example, certain amino acids and their derivatives are desirable as building blocks for surfactants, but selecting which amino acids to use is far from straightforward. The synthesis of such compounds adds an additional layer of difficulty due to differences in solubility that may result from different elements and moieties present in the same molecule. There remains a need for highly effective surfactants that can be easily synthesized on a commercial scale via a convenient route. Summary of the Invention

[0007] The present disclosure provides derivatives of amino acids that have surface-active properties. The amino acids may be natural or synthetic amino acids, or may be obtained via a ring-opening reaction of molecules such as lactams, e.g., caprolactam. The amino acids may be functionalized to form compounds with surface-active properties. Characteristically, these compounds have low critical micelle concentrations (CMCs). CMC) and / or the ability to reduce the surface tension of a liquid.

[0008] The present disclosure provides compounds of formula I, also referred to herein as surfactants:

[0009] [ka]

[0010] In the formula, R 1 , R 2 , and R 3 is independently selected from hydrogen and C1-C6 alkyl, i.e., C1, C2, C3, C4, C5, or C6; n is an integer from 2 to 5, i.e., 2, 3, 4, or 5; m is an integer from 9 to 20, i.e., 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20; and X is an anion that may be selected from the group consisting of chloride, bromide, iodide, and hydroxide.

[0011] The present disclosure specifically provides compounds of formula II, also referred to herein as surfactants:

[0012] [ka]

[0013] wherein X is an anion that may be selected from the group consisting of chloride, bromide, iodide, and hydroxide. One specific compound provided by the present disclosure is 6-(dodecyloxy)-N,N-dimethyl-6-oxohexan-1-aminium chloride, having the following formula:

[0014] [ka]

[0015] The above and other features of the present disclosure, and the manner in which they are achieved, will become more apparent and be better understood by referring to the following description of the embodiments in conjunction with the accompanying drawings. [Brief explanation of the drawings]

[0016] [Figure 1]FIG. 1 shows a plot of surface tension versus concentration measured at pH=7, as described in Example 2, where the Y-axis represents surface tension (γ) in millinewtons per meter (mN / m) and the X-axis represents concentration (c) in millimoles (mM). [Figure 2] FIG. 2 shows a plot of dynamic surface tension as a change in surface tension versus time, as described in Example 3, where the Y-axis represents surface tension in milliNewtons per meter (mN / m) and the X-axis represents surface elapsed time in milliseconds (ms). DETAILED DESCRIPTION OF THE INVENTION

[0017] As used herein, the phrase "within any range defined between any two of the above values" literally means that any range from any two of the values ​​listed before the phrase may be selected, regardless of whether the values ​​are toward the lower end of the list or toward the upper end of the list. For example, a pair of values ​​may be selected from the two lower values, the two upper values, or a lower value and an upper value.

[0018] As used herein, the term "alkyl" means any saturated carbon chain, which may be straight or branched. As used herein, the phrase "surface active" means that the associated compound is capable of lowering the surface tension of the medium in which it is dissolved and / or the interfacial tension with other phases, and therefore may adsorb to air-liquid interfaces and / or other interfaces. The term "surfactant" may be applied to such compounds.

[0019] With respect to terms of imprecision, the terms "about" and "approximately" may be used interchangeably to refer to a measurement that includes the stated measurement and includes any measurement that is reasonably close to the stated measurement. A measurement that is reasonably close to the stated measurement deviates from the stated measurement by a reasonably small amount that is understood and readily ascertained by one of ordinary skill in the art. Such deviations may be attributed, for example, to measurement error or small adjustments made to optimize performance. If one of ordinary skill in the art determines that a value for such a reasonably small difference would not be readily ascertainable, then the terms "about" and "approximately" may be understood to mean plus or minus 10% of the stated value.

[0020] The present disclosure provides derivatives of amino acids. The amino acids may be natural or synthetic amino acids, or may be obtained from the ring-opening reaction of lactams such as caprolactam. The compounds of the present disclosure have been shown to have surface-active properties and can be used, for example, as surfactants and wetting agents. In particular, the present disclosure provides compounds of Formula I, as shown below:

[0021] [ka]

[0022] In the formula, R 1 , R 2 , and R 3 is independently selected from hydrogen and C1-C6 alkyl, i.e., C1, C2, C3, C4, C5, or C6; n is an integer from 2 to 5, i.e., 2, 3, 4, or 5; m is an integer from 9 to 20, i.e., 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20; and X is an anion that may be selected from the group consisting of chloride, bromide, iodide, and hydroxide.

[0023] Alternatively, the present disclosure also provides compounds of Formula II, as shown below:

[0024] [ka]

[0025] wherein X is an anion that may be selected from the group consisting of chloride, bromide, iodide, and hydroxide. One specific compound provided by the present disclosure is 6-(dodecyloxy)-N,N-dimethyl-6-oxohexan-1-aminium chloride, having the following formula:

[0026] [ka]

[0027] These compounds can be synthesized by various methods. One such method involves ring-opening a lactam to obtain an amino acid having an N-terminus, and reacting the N-terminus of the amino acid with an alkylating agent to obtain a tertiary amine. The resulting tertiary amine can then be reacted with an alcohol under acidic conditions to obtain an amino acid ester having an N-terminus. The N-terminus of the amino acid ester can then be reacted with an acid to obtain a quaternary amine salt.

[0028] The amino acids may be natural or synthetic, or may be derived from the ring-opening reaction of lactams such as propiolactam, butyrolactam, valerolactam, and caprolactam. The ring-opening reaction may be either acid- or alkali-catalyzed, an example of an acid-catalyzed reaction is shown in Scheme 1 below.

[0029] [ka]

[0030] The amino acid may have as few as two or as many as five carbons, i.e., 2, 3, 4, or 5, between the N-terminus and C-terminus. The alkyl chain may be branched or straight. The alkyl chain may be interrupted by nitrogen, oxygen, or sulfur. The alkyl chain may be further substituted with one or more substituents selected from the group consisting of hydroxyl, amino, amido, sulfonyl, sulfonate, carboxyl, and carboxylate. The N-terminal nitrogen may be acylated or alkylated with one or more alkyl groups. For example, the amino acid may be 6-(dimethylamino)hexanoic acid.

[0031] Derivatives of amino acids can be synthesized as shown in Scheme 2 below. As shown, 6-aminohexanoic acid is treated with formaldehyde in formic acid under reflux to give 6-(dimethylamino)hexanoic acid. This free carboxylic acid is then converted to p The N-terminus is then alkylated with methyl iodide in the presence of sodium carbonate.

[0032] [ka]

[0033] The compounds of the present disclosure exhibit surface active properties. These properties can be measured and expressed by various methods. One way to express surfactants is by the critical micelle concentration (CMC) of the molecule. CMC can be defined as the concentration of surfactant that forms micelles, and at a higher concentration, all additional surfactants are incorporated into the micelles.

[0034] As surfactant concentration increases, surface tension decreases. When the surface is completely covered with surfactant molecules, micelles begin to form. This point represents the CMC, or minimum surface tension. Adding more surfactant does not further affect the surface tension. The CMC can therefore be measured by observing the change in surface tension as a function of surfactant concentration. One such method for measuring this value is the Wilhelmy plate method. A Wilhelmy plate is typically a thin iridium-platinum plate attached to a balance by wires and positioned perpendicular to the air-liquid interface. The balance is used to measure the force exerted on the plate by wetting. This value is then used to calculate the surface tension (γ) according to Equation 1: Equation 1: γ = F / l cosθ where l is equal to the wetted perimeter (2w+2d, where w and d are the thickness and width of the plate, respectively), and for cosθ, the contact angle between the liquid and the plate is assumed to be 0 in the absence of an existing literature value.

[0035] Another parameter used to evaluate the performance of surfactants is dynamic surface tension. Dynamic surface tension is the value of the surface tension of a particular surface or interface over time. For liquids to which surfactants have been added, this may differ from the equilibrium value. Immediately after the surface is created, the surface tension is equal to that of the pure liquid. As mentioned above, surfactants reduce surface tension, so the surface tension decreases until it reaches an equilibrium value. The time required to reach equilibrium depends on the diffusion and adsorption rates of the surfactant.

[0036] One method for measuring dynamic surface tension is with a maximum bubble pressure tensiometer. This device measures the maximum internal pressure of a bubble formed in a liquid by a capillary. The measured value corresponds to the surface tension at a specific surface elapsed time, which is the time from the start of bubble formation to the maximum pressure. The dependence of surface tension on surface elapsed time can be measured by varying the rate at which the bubbles are generated.

[0037] Surface-active compounds can also be evaluated by their ability to wet on solid substrates, as measured by contact angle. When a liquid droplet contacts a solid surface in a third medium, such as air, a three-phase line is formed between the liquid, the gas, and the solid. The angle between the surface and the unit vector of surface tension, which is tangent to the droplet and plays a role in the three-phase line, is expressed as the contact angle. The contact angle (also known as the wetting angle) is a measure of the wettability of a solid by a liquid. In the case of complete wetting, the liquid spreads completely on the solid, and the contact angle is 0°. Wetting properties are typically measured at concentrations between 1 and 100 x CMC for a given compound, but since it is not a concentration-dependent property, measurements of wetting properties may be measured at higher or lower concentrations.

[0038] In one method, an optical contact angle goniometer can be used to measure contact angles. This instrument uses a digital camera and software to determine the contact angle by analyzing the contour shape of a sedentary drop of liquid on a surface.

[0039] Potential applications for the surface-active compounds of the present disclosure include formulations for use as shampoos, hair conditioners, detergents, spot-free rinse solutions, floor and carpet cleaners, cleaners for graffiti removal, wetting agents for crop protection, adjuvants for crop protection, and wetting agents for aerosol spray coatings.

[0040] Those skilled in the art will appreciate that small differences between compounds can lead to significantly different surfactant properties, and therefore different compounds may be used for different substrates and in different applications.

[0041] The following non-limiting examples are provided to illustrate the different properties of different surfactants. The compounds are effective as surfactants and are useful as wetting or foaming agents, dispersing agents, emulsifying agents, and detergents, among other uses.

[0042] The compounds of the present disclosure may be useful in both the applications mentioned above and in some further specialized applications, such as in personal hair care products, as surface treatments, and may also be used to create water-repellent surfaces.

[0043] The amount of a compound disclosed herein used in the formulation can be as low as about 0.001%, about 0.05%, about 0.1%, about 0.5%, about 1%, about 2%, or about 5% by weight, or as high as about 8%, about 10%, about 15%, about 20%, or about 25% by weight, or within any range defined between any two of the above values.

[0044] Example Nuclear magnetic resonance (NMR) spectroscopy was performed on a Bruker 500 MHz spectrometer. The critical micelle concentration (CMC) was determined at 23 °C using a tensiometer (DCAT 11, DataPhysics Instruments GmbH) equipped with a Pt-Ir plate by the Wilhelmy plate method. The dynamic surface tension was determined at 23 °C using a maximum bubble pressure tensiometer (Kruss BP100, Kruss GmbH). The contact angle was determined using an optical contact angle goniometer (OCA 15 Pro, DataPhysics GmbH) equipped with a digital camera.

[0045] Example 1: Synthesis of 6-(dodecyloxy)-N,N-dimethyl-6-oxohexane-1-aminium chloride 6-(Dimethylamino)hexanoic acid (11.99 g, 75.36 mmol) was dissolved in toluene (50 mL) in a round-bottom flask equipped with a Dean-Stark trap. Next, dodecanol (12.68 g, 75.36 mmol) and p-toluenesulfonic acid monohydrate (PTSA) (14.33 g, 75.36 mmol) were added. The reaction was heated to reflux for 24 hours until no further water was observed in the Dean-Stark trap. The solvent was removed under vacuum, and the resulting solid was washed with hexane. This solid was dissolved in dichloromethane (200 mL) and washed with saturated sodium carbonate to give dodecyl 6-(dimethylamino)hexanoate in 51% yield. 1 H NMR(DMSO)δ 4.00(t,J=6.5Hz,2H),2.27(t,J=7.3Hz,2H),2.13-2.16(m,2H),2.01(s,6H),1.54-1.53(m,6H),1.27-1.18(m,20H),0.86(t,3H).

[0046] Dodecyl 6-(dimethylamino)hexanoate (100 mg, 0.305 mmol) was dissolved in water (10 mL). Concentrated hydrochloric acid (11.14 mg, 0.305 mmol) was added.

[0047] Example 2: Identifying the critical micelle concentration (CMC) The critical micelle concentration (CMC) was determined. From the change in surface tension with aqueous solution concentration, the CMC was determined to be approximately 1.4 mmol. The plateau value of the minimum surface tension achievable with this surfactant is approximately 30 mN / m, i.e., 30 mN / m ± 3 mN / m. Figure 1 is a plot of these results, showing surface tension versus concentration. From the plot of these results, the surface tension at the CMC is approximately 30 mN / m or less. The plot also shows that at concentrations of 2.7 mmol or greater, the surface tension is 33 mN / m or less.

[0048] Example 3: Determining dynamic surface tension Dynamic surface tension was determined using a maximum bubble pressure tensiometer, which measures the change in surface tension of a newly created air-water interface over time. Figure 2 shows a plot of surface tension versus time, showing that over the time interval of 1 to 100 ms, the surface tension rapidly decreases from approximately 50 mN / m to approximately 40 mN / m. Over the time interval of 100 to 50,000 ms, the surface tension decreases more slowly from 40 mN / m to approximately 34 mN / m, asymptotically approaching the saturated value of surface tension at the CMC.

[0049] Example 4: Identification of wetting properties In addition to surface tension and surface kinetics, the wetting properties of the compounds were tested on various surfaces. For example, hydrophobic substrates such as polyethylene-HD exhibit a surface wetting contact angle of 42.5°. On oleophobic and hydrophobic substrates such as Teflon®, the measured contact angle was 66.6°, much lower than that of water (Table 1).

[0050] [Table 1]

[0051] Example 5: Shampoo preparations In this example, a formulation for use as a shampoo is provided. The formulation is useful for imparting a smooth, silky feel to hair. The ingredients of the formulation are shown in Table 2 below. In addition, the formulation may contain other natural oils and ingredients, as well as vitamins for consumer appeal, in amounts less than 1% by weight.

[0052] [Table 2]

[0053] Example 6: Hair conditioner formulations This example provides a formulation for use as a hair conditioner that can be used to replace or reduce polyquaternium-10, polyquaternium-7, and dimethicone oil while retaining the combability and silky soft feel that hair conditioners provide.

[0054] The formulations are shown in Table 3 below.

[0055] [Table 3]

[0056] Example 7: Car wash detergent formulations for removing tough spot stains from surfaces In this example, a formulation is provided for use in a car wash detergent to remove tough spot soils from a surface.

[0057] The formulations are shown in Table 4 below.

[0058] [Table 4]

[0059] Example 8: Formulation for spot-free rinse or dry solution This example provides the formulation of a spot-free rinse or drying solution that can be applied to the windows or body of an automobile after the main wash is complete.

[0060] The formulations are shown in Table 5 below.

[0061] [Table 5]

[0062] Example 9: Heavy-duty carpet cleaner formulations This example provides a formulation for a heavy duty carpet cleaner, which is a high foaming deep cleaner.

[0063] The formulations are shown in Table 6 below.

[0064] [Table 6]

[0065] Example 10: Heavy-Duty Surface Cleaner Formulations This example provides a formulation for a heavy-duty surface cleaner that can be used for manual or automatic surface cleaning machines.

[0066] The formulations are shown in Table 7 below.

[0067] [Table 7]

[0068] Example 11: Concentrated graffiti removal detergent formulation This example provides a formulation for a concentrated graffiti removal detergent that can be used with high pressure hoses.

[0069] The formulations are shown in Table 8 below.

[0070] [Table 8]

[0071] Example 12: Formulation for wetting agents in aerosol sprays In this example, a formulation is provided for use as a wetting adjuvant in an aerosol spray, which may be used to apply insecticides or other crop protection agents. The provided formulation aims to reduce the amount of surfactant chemicals in insecticides and other crop protection agents (typically 2-5%) by providing superior wetting and better performance with a low CMC, thus providing a more environmentally friendly option.

[0072] The formulations are shown in Table 9 below.

[0073] [Table 9]

[0074] Example 13: Formulation of additives for aerosol spray paints This example provides a formulation for a water-based aerosol spray paint or coating additive that aims to provide good dynamic wetting of the aerosol droplets on the surface after application, thus preventing paint cratering and other such problems.

[0075] The formulations are shown in Table 10 below.

[0076] [Table 10]

[0077] Aspects Aspect 1 is a compound of the formula:

[0078] [ka]

[0079] wherein X is an anion selected from the group consisting of chloride, bromide, iodide, and hydroxide. Aspect 2 is a compound according to Aspect 1 which is 6-(dodecyloxy)-N,N-dimethyl-6-oxohexan-1-aminium chloride having the formula:

[0080] [ka]

[0081] Aspect 3 is a compound according to Aspect 1 or Aspect 2, having a critical micelle concentration (CMC) in aqueous solution of about 1.4 mmol. Aspect 4 is the compound according to any one of Aspects 1 to 3, wherein the minimum surface tension plateau value in aqueous solution is about 30 mN / m.

[0082] Aspect 5 is the compound according to any one of Aspects 1 to 4, which has a surface tension of 33 mN / m or less in aqueous solution at a concentration of 2.7 mmol or more. Aspect 6 is the compound according to any one of Aspects 1 to 5, wherein the surface tension of an aqueous solution is 40 mN / m or less at a surface transit time of 100 ms or more.

[0083] Aspect 7 is a method for synthesizing an amino acid surfactant, comprising the steps of: (1) ring-opening a lactam to obtain an amino acid having an N-terminus; (2) reacting the N-terminus of the amino acid with an alkylating agent to obtain a tertiary amine; (3) reacting the tertiary amine with an alcohol under acidic conditions to obtain an amino acid ester having an N-terminus; and (4) reacting the N-terminus of the amino acid ester with an acid to obtain an amino acid surfactant of the formula:

[0084] [ka]

[0085] wherein X is an anion selected from the group consisting of chloride, bromide, iodide, and hydroxide. Example 8 is the method of Example 7, wherein in step 1, the lactam is caprolactam.

[0086] Aspect 9 is the method of aspect 7 or aspect 8, wherein in step 2, the alkylating agent is formaldehyde or paraformaldehyde. Aspect 10 is the method of any one of Aspects 7 to 9, wherein in Step 3, the alcohol is dodecanol.

[0087] Aspect 11 is the method of any one of Aspects 7 to 10, wherein in Step 3, the acid is p-toluenesulfonic acid. Aspect 12 is the method of any one of Aspects 7 to 11, wherein in Step 4, the acid is hydrochloric acid.

[0088] A thirteenth aspect is a composition comprising a vehicle and a surfactant of the following formula:

[0089] [ka]

[0090] wherein X is an anion selected from the group consisting of chloride, bromide, iodide, and hydroxide. Example 14 is the composition of Example 13, wherein the medium is water.

Claims

1. Water, and The following formula 【Chemistry 1】 wherein X is an anion selected from the group consisting of chloride, bromide, iodide, and hydroxide, and having a critical micelle concentration (CMC) of 1.4 mmol; A liquid composition comprising:

2. 2. The liquid composition of claim 1, wherein X is a bromide ion.

3. 2. The liquid composition of claim 1, wherein X is an iodide ion.

4. 2. The liquid composition of claim 1, wherein X is a hydroxide ion.

5. The surfactant has the following formula: 【Chemistry 2】 2. The liquid composition according to claim 1, wherein the compound is 6-(dodecyloxy)-N,N-dimethyl-6-oxohexane-1-aminium chloride having the formula:

6. 6. The liquid composition of claim 5, wherein the surfactant has a minimum surface tension plateau value in water of 30 mN / m.

7. 6. The liquid composition of claim 5, wherein the surfactant has a surface tension of 33 mN / m or less in water at a concentration of 2.7 mmol or more.

8. 6. The liquid composition of claim 5, wherein the surfactant has a surface tension of 40 mN / m or less in water at a surface dwell time of 100 ms or more.

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