Drug delivery device and balloon catheter

Abstract

To provide a drug delivery device and a balloon catheter capable of delivering a drug over the entire outer peripheral surface of a medical device.SOLUTION: A drug delivery device 1A has a tubular shape, and includes: a supply tube 2A that has a lumen 20L through which the drug supplied from a proximal end part 20P passes; a release section 3A that is provided at a distal end part 20D of the supply tube 2A and releases the drug supplied to the supply tube 2A toward the medical device; a holding member 4A that holds the drug delivery device against the medical device, is provided somewhere between the proximal end part 20P and the distal end part 20D of the supply tube 2A, and holds the medical device and the supply tube 2A in a rotatable state relative to each other. In the drug delivery device 1A, a central shaft C1 passing through the center of the supply tube 2A does not coincide with a first rotation axis R11, which is the rotation axis of the supply tube 2A held by the holding member 4A relative to the medical device.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a drug delivery device and a balloon catheter. [Background technology]

[0002] An apparatus for supplying a drug to a medical device such as a balloon catheter in a living body has been proposed. Patent Document 1 discloses a catheter for administering a drug supplied to a balloon to a tumor. The catheter has a balloon, a first conduit, and a second conduit. The balloon is connected to the tip of the first conduit and communicates with a first lumen formed in the first conduit. The first conduit further has a second lumen through which a second conduit is inserted. The second conduit is movable in the direction in which the second lumen extends (hereinafter referred to as the extension direction). A drug discharge port is formed at the tip of the second conduit. The drug discharged from the drug discharge port adheres to the outer surface of the balloon. The balloon expands and presses against the tumor, thereby administering the drug on the outer surface of the balloon to the tumor. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2012-157606 Summary of the Invention [Problem to be solved by the invention]

[0004] In the above catheter, the drug discharge port can only move in the stretching direction, and cannot move in a direction perpendicular to the stretching direction, which can cause the problem that the drug cannot be supplied over the entire outer circumferential surface of the balloon.

[0005] An object of the present invention is to provide a drug delivery device and a balloon catheter that are capable of delivering a drug over the entire outer peripheral surface of a medical device. [Means for solving the problem]

[0006] A drug supply device according to a first aspect of the present invention is a drug supply device that supplies a drug to a medical device, and comprises: a supply tube having a tubular shape and an inner cavity through which the drug supplied from a base end passes; a release section provided at a tip end of the supply tube opposite the base end, which releases the drug supplied to the supply tube toward the medical device; and a holding member that holds the drug supply device relative to the medical device, which is provided at a position between the base end and the tip end of the supply tube, and holds the medical device and the supply tube in a state in which they can rotate relatively, and is characterized in that a central axis passing through the center of the supply tube does not coincide with a first rotation axis that is the rotation axis when the supply tube held by the holding member rotates relative to the medical device.

[0007] The drug supply device can move the release portion provided at the tip of the supply tube over the entire circumferential area of ​​the medical device by rotating the medical device and the supply tube relative to each other, so that the drug supplied to the supply tube can be supplied over the entire circumferential area of ​​the medical device via the release portion.

[0008] In a first aspect, the holding member may have an annular member having a first through hole, the first rotation axis may pass through the center of the first through hole, and the central axis may not pass through the first through hole. In this case, the drug supply apparatus can realize a mechanism for holding the medical device and the supply tube in a relatively rotatable state with a simple configuration.

[0009] In the first aspect, the holding member may hold the medical device and the supply tube in a state in which they can move relative to each other in a direction along the central axis, which makes it possible, for example, to apply a drug to the medical device using a drug supply device just before a lesion, and then move the medical device toward the lesion.

[0010] In the first aspect, the discharge portion may be rotatable relative to the supply pipe. In this case, the drug supply device can reduce friction between the discharge portion and the medical device when supplying the drug to the medical device. Therefore, the drug supply device can reliably supply the drug to the medical device without leakage.

[0011] In the first aspect, a second rotation axis, which is the axis of rotation when the release portion rotates relative to the supply tube, may extend parallel to the first rotation axis. In this case, the drug supply device can supply the drug to the medical device while rotating the release portion by rotating the medical device and the supply tube relatively.

[0012] In the first aspect, the release portion may be rotatable relative to the supply pipe, and a second rotation axis, which is the axis of rotation when the release portion rotates relative to the supply pipe, may extend in a direction intersecting with the first rotation axis. In this case, the drug supply device can supply the drug to the medical device while rotating the release portion by moving the medical device and the supply pipe relative to each other in a direction along the central axis.

[0013] In the first aspect, the drug supply device may have a plurality of the discharge portions, and the supply pipe may have a branch portion at the tip portion that connects to the plurality of discharge portions. In this case, the drug supply device can efficiently supply the drug to the medical device using the plurality of discharge portions.

[0014] In the first aspect, the drug delivery device may further include a shaft that is provided along the supply tube and is stiffer than the supply tube, so that a user of the drug delivery device can easily deliver the supply tube and the release portion to a desired position by utilizing the stiffness of the shaft.

[0015] In the first aspect, the release section may include a tubular passage tube having an inner cavity through which the drug supplied from the supply tube passes, and a second through hole provided in the passage tube for releasing the drug passing through the inner cavity of the passage tube to the outside. In this case, the drug supply device can easily realize a configuration for releasing the drug supplied from the supply tube toward the medical device with a simple configuration.

[0016] In a first aspect, the medical device is a balloon catheter including a catheter shaft and a balloon attached to the catheter shaft, the annular member holds the catheter shaft and the supply tube in a relatively rotatable state, and the inner diameter of the annular member may be larger than the outer diameter of the deflated balloon and smaller than the outer diameter of the inflated balloon. In this case, a user of the drug supply device can easily position the drug supply device relative to the medical device.

[0017] In a first aspect, the medical device is a balloon catheter including a catheter shaft and a balloon attached to the catheter shaft, and the release portion releases the drug toward the balloon, and at least a portion of the outer surface of the release portion may have a pointed shape. In this case, for example, by inflating the balloon with the release portion disposed on the side of the balloon, the pointed portion of the release portion can be applied to a lesion or the like in a blood vessel to perform treatment.

[0018] A balloon catheter according to a second aspect of the present invention includes a catheter shaft, a balloon attached to the catheter shaft, a tubular supply tube having a lumen through which a drug is supplied from a base end, a release section attached to a tip end of the supply tube opposite the base end and configured to release the drug supplied to the supply tube toward the balloon, and a holding member for holding the supply tube relative to the catheter shaft, the holding member being attached to a position between the base end and the tip end of the supply tube and holding the catheter shaft and the supply tube in a relatively rotatable state, wherein a central axis passing through the center of the supply tube does not coincide with a first rotation axis about which the supply tube rotates while held by the holding member. The second aspect can achieve the same effects as the first aspect. [Brief explanation of the drawings]

[0019] [Figure 1] 1A and 1B are diagrams showing a medicine supply device 1A and cross-sectional views of each part. [Figure 2] FIG. 1 is a diagram showing a balloon catheter 9. [Figure 3] 1A and 1B are diagrams showing a drug supply device 1A and a balloon catheter 9. FIG. [Figure 4] 1A and 1B are diagrams illustrating a first example of how to use the medicine supply device 1A. [Figure 5] FIG. 10 is a diagram showing a modified example of the medicine supply device 1A. [Figure 6] 10A and 10B are diagrams illustrating a second example of how to use the medicine supply device 1A. [Figure 7] FIG. 2 is a diagram showing a medicine supply device 1B. [Figure 8] FIG. 1 is a diagram showing a medicine supply device 1C. [Figure 9] FIG. 1 is a diagram showing a medicine supply device 1D. DETAILED DESCRIPTION OF THE INVENTION

[0020] An embodiment of a medicine supply device 1 according to the present invention will be described with reference to the drawings. The drawings are used to explain technical features that can be adopted by the present invention, and the configuration of the device described therein is not intended to be limiting but is merely an illustrative example.

[0021] <Overview of the medicine supply device 1> Balloon catheters are known as devices for dilating stenotic lesions (hereinafter referred to as "stenotic lesions") formed in vascular vessels such as blood vessels, vas deferens, fallopian tubes, and lymphatic vessels, thereby reperfusing the vessels. The ability of a balloon catheter to dilate a stenotic lesion depends on the physical dilatation capability of the balloon. However, even with enhanced dilatation capabilities, conventional balloon catheters may fail to fully dilate a stenotic lesion. Possible causes of this include the elasticity of the vessel, abnormal proliferation of cells in the stenotic lesion, and restenosis of the lesion after treatment.

[0022] In response to this, devices that use drugs to treat stenotic lesions are known to directly suppress the causes of stenotic lesion formation and improve treatment efficiency. One example of such a device is a balloon catheter with a drug-coated balloon. With this balloon catheter, the drug coated on the balloon adheres to the stenotic lesion when the balloon is expanded, allowing for effective treatment of the stenotic lesion.

[0023] When using the above-mentioned balloon catheter, the amount of drug applied to the balloon may be insufficient for the treatment of the stenotic lesion. If it is not possible to replenish the balloon with drug, the balloon catheter used for treatment must be removed from the body and a new balloon catheter must be reinserted. This may result in inconveniences such as increased burden on the balloon catheter user (operator) and patient, and reduced therapeutic effectiveness.

[0024] In contrast, the drug supply device 1 according to this embodiment (see FIG. 1, etc.) allows the balloon 9B to be replenished with a drug without the need to remove the balloon catheter 9 (see FIG. 2, etc.) from the body. Furthermore, the drug supply device 1 can apply a drug to the entire circumferential area of ​​the balloon 9B. This allows for effective treatment of stenotic lesions using the balloon 9B.

[0025] <First embodiment - medicine supply device 1A> A medicine supply device 1A according to a first embodiment will be described with reference to Fig. 1. The medicine supply device 1A includes a supply tube 2A, a release portion 3A, and a holding member 4A.

[0026] The supply tube 2A is a flexible tubular member. The supply tube 2A has a lumen 20L with a circular cross section. One end of the supply tube 2A is referred to as the "base end 20P," and the other end is referred to as the "distal end 20D." A drug pump (not shown) is connected to the base end 20P to supply a drug toward the supply tube 2A. The drug supplied to the base end 20P by the drug pump passes through the lumen 20L and flows toward the distal end 20D.

[0027] The supply tube 2A is slightly bent at a bent portion 21 near the distal end 20D. The portion of the supply tube 2A that extends from the base end 20P to the bent portion 21 is referred to as the "first tube portion 201." The portion of the supply tube 2A that extends from the bent portion 21 to the distal end 20D is referred to as the "second tube portion 202." An imaginary axis passing through the center of the lumen 20L of the first tube portion 201 is referred to as the "central axis C1." The direction extending along the central axis C1 is referred to as the "extension direction."

[0028] The release section 3A is provided at the distal end 20D of the supply tube 2A. The release section 3A has a passing tube 30, which is a tubular member. NiTi is used as a material for the passing tube 30, for example. The passing tube 30 has a circular cross section when cut along a plane perpendicular to the extension direction, and has a lumen 30L. Of both ends of the passing tube 30, the end closest to the supply tube 2A is referred to as the "proximal end 30P," and the end remote from the supply tube 2A is referred to as the "distal end 30D." A portion of the supply tube 2A, including the distal end 20D, is disposed within the lumen 30L of the passing tube 30 of the release section 3A. The drug flowing through the lumen 20L of the supply tube 2A toward the distal end 20D is supplied to the proximal end 30P of the passing tube 30, passes through the lumen 30L, and flows toward the distal end 30D.

[0029] An imaginary axis passing through the center of the lumen 30L of the passage tube 30 of the release portion 3A is referred to as the "second rotation axis R21." The second rotation axis R21 extends along the extension direction. The release portion 3A is supported rotatably with respect to the supply tube 2A (arrow Y21). The center of rotation of the release portion 3A with respect to the supply tube 2A coincides with the second rotation axis R21. The release portion 3A is rotatable around the second rotation axis R21.

[0030] The passage tube 30 has a plurality of second through holes 31 communicating with the inner cavity 30L. Each second through hole 31 has a circular cross-sectional shape. The plurality of second through holes 31 are arranged at equal intervals in the circumferential direction and at equal intervals in the extension direction. The drug flowing through the inner cavity 30L of the passage tube 30 is released to the outside through the plurality of second through holes 31 in response to the pressure applied by the drug pump.

[0031] The holding member 4A is provided in a portion of the supply pipe 2A between the base end 20P and the tip end 20D, more specifically, in a part of the bent portion 21 of the supply pipe 2A. The holding member 4A includes an annular member 40 having a first through hole 4H. The annular member 40 is made of stainless steel. The cross section of the first through hole 4H when cut along a plane perpendicular to the extension direction is circular. The central axis C1 of the supply pipe 2A does not pass through the first through hole 4H.

[0032] The axis that passes through the center of the first through-hole 4H and extends in the extension direction is referred to as the "first rotation axis R11." The first rotation axis R11 extends parallel to the second rotation axis R21 of the release portion 3A. Furthermore, the first rotation axis R11 does not coincide with the central axis C1, but is spaced apart in a direction perpendicular to the extension direction (hereinafter referred to as the "orthogonal direction").

[0033] Hereinafter, the side in the extension direction from the tip 30D of the releasing portion 3A toward the base end 20P of the supply pipe 2A will be referred to as the "base end side." The side opposite to the base end side in the extension direction, in other words, the side from the base end 20P of the supply pipe 2A toward the tip 30D of the releasing portion 3A will be referred to as the "tip side."

[0034] 2 shows a balloon catheter 9 including a balloon 9B to which a drug is delivered by the drug delivery device 1 A. The balloon catheter 9 has a catheter shaft 9A and a balloon 9B.

[0035] The catheter shaft 9A has an outer tube 91 and an inner tube 92. The outer tube 91 and the inner tube 92 are each a flexible tubular member. The inner diameter of the outer tube 91 is larger than the outer diameter of the inner tube 92. The outer diameter of the outer tube 91 is smaller than the inner diameter of the first through-hole 4H (see FIG. 1 ) of the holding member 4A of the drug supply device 1A. The inner tube 92 is disposed in the lumen of the outer tube 91 except for a predetermined portion on the distal end side. A distal end portion of the inner tube 92 protrudes toward the distal end from the distal end of the outer tube 91. A distal end portion of the inner tube 92 is disposed distal to the distal end of the outer tube 91. A guide wire (not shown) is inserted through the lumen of the inner tube 92. A fluid hub (not shown) is connected to the proximal end of the catheter shaft 9A.

[0036] The balloon 9B is connected to the distal end of the catheter shaft 9A. The distal end of the balloon 9B is connected to the distal end of the inner tube 92. The proximal end of the balloon 9B is connected to the distal end of the outer tube 91. The balloon 9B covers the portion of the inner tube 92 that protrudes further distally than the outer tube 91.

[0037] The fluid hub supplies compressed fluid to the space within the lumen of outer tube 91 excluding the lumen of inner tube 92. In response to the supply of compressed fluid, balloon 9B changes shape from a contracted state to an expanded state. FIG. 2 shows balloon 9B in an expanded state. FIG. 3A shows balloon 9B in a contracted state. As shown in FIG. 3A, the outer diameter of balloon 9B in the contracted state is smaller than the inner diameter of first through-hole 4H of holding member 4A of drug supply device 1A.

[0038] The diameter of balloon 9B varies depending on the amount of compressed fluid supplied. For example, balloon 9B in the expanded state shown in FIG. 3B has a smaller diameter than balloon 9B in the expanded state shown in FIG. 2 because a smaller amount of compressed fluid is supplied to balloon 9B in the expanded state shown in FIG. 2. Hereinafter, the expanded state of balloon 9B shown in FIG. 2 will be referred to as the "maximum expanded state," and the expanded state of balloon 9B shown in FIG. 3B will be referred to as the "intermediate expanded state." The outer diameter of balloon 9B in the intermediate expanded state and the maximum expanded state is larger than the inner diameter of first through-hole 4H (see FIG. 1) of holding member 4A of drug supply device 1A.

[0039] As shown in Figure 2, the balloon 9B has a distal cone portion 93, an expansion portion 94, and a proximal cone portion 95. When the balloon 9B is inflated (see Figures 2 and 3B), the distal cone portion 93 extends from its connection with the distal end of the inner tube 92 toward the proximal end while expanding in diameter. The proximal cone portion 95 extends from its connection with the distal end of the outer tube 91 toward the distal end while expanding in diameter. The expansion portion 94 extends in the extension direction between the proximal end of the distal cone portion 93 and the distal end of the proximal cone portion 95.

[0040] As shown in Figures 3A and 3B, a catheter shaft 9A of a balloon catheter 9 is inserted into a first through-hole 4H of an annular member 40 of a holding member 4A of a drug supply device 1A. The drug supply device 1A is held on the balloon catheter 9 by the holding member 4A. A balloon 9B is disposed on the distal side of the holding member 4A. The position of an expansion section 94 of the balloon 9B coincides with the release section 3A of the drug supply device 1A in the extension direction.

[0041] The drug supply device 1A is rotatable relative to the balloon catheter 9 (arrow Y11). The axis of rotation of the drug supply device 1A relative to the balloon catheter 9 coincides with the first axis of rotation R11 of the holding member 4A. Furthermore, the balloon catheter 9 is rotatable relative to the drug supply device 1A (arrow Y12) with the catheter shaft 9A inserted through the first through-hole 4H of the annular member 40 of the holding member 4A. The axis of rotation of the balloon catheter 9 relative to the drug supply device 1A coincides with the first axis of rotation R11 of the holding member 4A. In other words, the first axis of rotation R11 corresponds to the axis of rotation of the balloon catheter 9 and the supply tube 2A when they rotate relative to each other.

[0042] Furthermore, the drug supply device 1A is movable relative to the balloon catheter 9 in a direction along the central axis C1 of the supply tube 2A, ie, in the extending direction (arrow Y31).

[0043] As shown in Fig. 3A, when the balloon 9B of the balloon catheter 9 is in a deflated state, the release portion 3A of the drug supply device 1A held on the catheter shaft 9A by the holding member 4A is spaced apart in a direction perpendicular to the balloon 9B. On the other hand, as shown in Fig. 3B, when the balloon 9B of the balloon catheter 9 is in an intermediately inflated state, the release portion 3A of the drug supply device 1A held on the catheter shaft 9A by the holding member 4A comes into contact with the inflated portion 94 of the balloon 9B.

[0044] A method of using the drug delivery device 1A will be described with reference to Figure 4. This example illustrates a case in which the drug delivery device 1A and the balloon catheter 9 are used to dilate a portion of a blood vessel 8 that has been blocked by a stenotic lesion 80 that has developed in part of the inner wall.

[0045] A balloon catheter 9 is prepared with drug supply device 1A held therein. Discharge portion 3A of drug supply device 1A and balloon 9B of balloon catheter 9 are placed in blood vessel 8. Balloon 9B is deflated. The user operates the proximal ends of supply tube 2A of drug supply device 1A and catheter shaft 9A of balloon catheter 9 to move drug supply device 1A and balloon catheter 9 in blood vessel 8 distally toward stenotic lesion 80. When discharge portion 3A and balloon 9B reach positions close to the proximal side of stenotic lesion 80, the user stops the movement of drug supply device 1A and balloon catheter 9 (see FIG. 4A ).

[0046] Next, as shown in FIG. 4B, the user operates the fluid hub to supply compressed fluid to the catheter shaft 9A of the balloon catheter 9. The balloon 9B expands from a deflated state to an intermediately expanded state. The expansion portion 94 of the balloon 9B contacts the discharge portion 3A. Next, the user operates the proximal end of the catheter shaft 9A to rotate the balloon 9B around the first rotation axis R11 (arrow Y12). In response to the rotation of the balloon 9B, the discharge portion 3A, which is in contact with the balloon 9B, rotates around the second rotation axis R21 relative to the supply tube 2A (arrow Y21).

[0047] Next, the user operates the drug pump to supply the drug to the supply tube 2A of the drug supply device 1A. The drug supplied to the supply tube 2A is further supplied to the lumen 30L of the passage tube 30 of the release portion 3A. The drug supplied to the lumen 30L is released into the balloon 9B through the plurality of second through-holes 31 provided in the passage tube 30. The released drug adheres to the inflation portion 94 of the balloon 9B. Note that, because the balloon 9B rotates about the first rotation axis R11, the drug released from the release portion 3A adheres to the entire circumferential area of ​​the balloon 9B.

[0048] After the drug has adhered to the entire circumferential area of ​​balloon 9B, the user operates the drug pump to stop the supply of drug to supply tube 2A of drug supply device 1A. The user also stops the rotation of balloon catheter 9. Next, the user operates the fluid hub to remove the compressed fluid from balloon 9B. Balloon 9B contracts from the intermediately inflated state to the deflated state.

[0049] Next, the user operates the proximal end of the catheter shaft 9A to move the balloon 9B distally toward the stenotic lesion 80. Note that the drug delivery device 1A is not operated or moved. When the balloon 9B reaches the stenotic lesion 80, the user stops the movement of the balloon catheter 9 (see FIG. 4C).

[0050] Next, as shown in Figure 4D, the user operates the fluid hub to supply compressed fluid to the catheter shaft 9A of the balloon catheter 9. The balloon 9B expands from a deflated state to an intermediate expanded state and then to a fully expanded state. The balloon 9B contacts the stenotic lesion 80 from the inside and pushes it outward. The balloon 9B also causes the drug attached to the surface of the expansion portion 94 to act on the stenotic lesion 80. This causes the portion of the blood vessel 8 that is blocked by the stenotic lesion 80 to expand.

[0051] Next, the user operates the fluid hub to remove the compressed fluid from the balloon 9B. The balloon 9B contracts from the maximum expanded state to a contracted state. Next, the user operates the proximal end of the catheter shaft 9A to move the balloon 9B proximally. When the balloon 9B moves to a position where it overlaps with the release portion 3A of the drug delivery device 1A in the extension direction, the user stops the movement of the balloon catheter 9 (see FIG. 4E).

[0052] If it is necessary to bring the balloon 9B into contact with the stenotic lesion 80 again to dilate the blood vessel 8, the user operates the fluid hub to supply compressed fluid to the catheter shaft 9A of the balloon catheter 9. As shown in FIG. 4B , the balloon 9B expands from the deflated state to the intermediately expanded state, and the expansion portion 94 contacts the release portion 3A. Next, the user rotates the balloon 9B around the first rotation axis R11 (arrow Y12). In response to the rotation of the balloon 9B, the release portion 3A also rotates around the second rotation axis R21 (arrow Y21). Next, the user operates the drug pump to supply a drug to the supply tube 2A of the drug supply device 1A. The drug supplied to the supply tube 2A is released into the balloon 9B through the multiple second through-holes 31 in the passage tube 30 of the release portion 3A. The released drug adheres to the entire circumferential area of ​​the balloon 9B.

[0053] 4C, 4D, and 4E are then performed. As a result, the balloon 9B with the drug attached thereto again contacts the stenotic lesion 80 from the inside. The balloon 9B also allows the drug attached to the surface of the inflation portion 94 to act on the stenotic lesion 80 again.

[0054] <Actions and Effects of the First Embodiment> In drug supply device 1A, central axis C1 passing through the center of first tube portion 201 of supply tube 2A is different from first rotation axis R11 when supply tube 2A and balloon catheter 9 rotate relative to each other. A user of drug supply device 1A can rotate balloon 9B in an intermediate inflation state relative to drug supply device 1A, thereby moving release portion 3A provided at tip end 20D of supply tube 2A over the entire circumferential area of ​​balloon 9B. Therefore, drug supply device 1A can release the drug from release portion 3A over the entire circumferential area of ​​balloon 9B, thereby allowing the drug to adhere over the entire circumferential area of ​​balloon 9B.

[0055] The holding member 4A has an annular member 40 with a first through-hole 4H and holds the supply tube 2A in a rotatable state relative to the balloon catheter 9. The first rotation axis R11 passes through the center of the first through-hole 4H, while the central axis C1 of the supply tube 2A does not pass through the first through-hole 4H. This allows the drug supply device 1A to be rotatably held relative to the balloon catheter 9 with a simple configuration, while enabling drug to be released from the release portion 3A over the entire circumferential area of ​​the balloon 9B in the intermediate inflation state. Furthermore, the annular member 40 can suppress frictional force generated at the contact portion with the catheter shaft 9A during rotation of the balloon catheter 9, thereby allowing the balloon catheter 9 to rotate smoothly relative to the drug supply device 1A. Furthermore, using the annular member 40 as the holding member 4A allows the balloon catheter 9 to be easily detached from the drug supply device 1A.

[0056] The holding member 4A holds the drug supply device 1A in a state where it can move in a direction along the central axis C1 of the first tube portion 201 of the supply tube 2A, i.e., in the extension direction, relative to the balloon catheter 9. In this case, for example, a user can use the drug supply device 1A to attach a drug to the balloon 9B just before the stenotic lesion 80 (FIG. 4B), and then move only the balloon 9B toward the stenotic lesion 80 (FIG. 4C), thereby treating the stenotic lesion 80 with the balloon 9B.

[0057] The release portion 3A is rotatable relative to the supply pipe 2A. In response to the rotation of the balloon 9B about the first rotation axis R11, the release portion 3A in contact with the balloon 9B rotates about the second rotation axis R21 (arrow Y21). This allows the drug supply device 1A to reduce the frictional force between the release portion 3A and the balloon 9B when the drug is attached to the balloon 9B. In this case, the drug can be reliably supplied to the balloon 9B without leakage.

[0058] The second rotation axis R21, which is the rotation axis when the releasing portion 3A rotates relative to the supply tube 2A, extends parallel to the first rotation axis R11, which is the rotation axis when the balloon catheter 9 rotates relative to the drug supply device 1A. In this case, the balloon 9B and the releasing portion 3A can rotate while maintaining contact between the releasing portion 3A and the balloon 9B over a wide area in the extension direction. Therefore, the drug supply device 1A can smoothly rotate the releasing portion 3A in response to the rotation of the balloon 9B, and attach the drug to the balloon 9B.

[0059] The release section 3A has a passage tube 30 formed with a plurality of second through holes 31. The release section 3A releases the drug passing through the inner cavity 30L of the passage tube 30 into the balloon 9B via the plurality of second through holes 31. In this case, the drug supply device 1A can easily achieve a configuration for releasing the drug supplied from the supply tube 2A toward the balloon 9B with a simple configuration.

[0060] For example, the positioning of the drug supply device 1A relative to the balloon catheter 9 can be performed, for example, by the following method. The user moves the drug supply device 1A toward the balloon 9B in the intermediately inflated state, from the proximal end toward the distal end. The inner diameter of the first through-hole 4H is smaller than the outer diameter of the balloon 9B in the intermediately and fully inflated states (see FIG. 3B). Therefore, when the annular member 40 of the holding member 4A reaches the proximal end of the balloon 9B, the annular member 40 catches on the balloon 9B, preventing the drug supply device 1A from moving toward the distal end. In this state, the release section 3A of the drug supply device 1A is positioned so as to overlap with the balloon 9B in the extension direction. In this way, the user can easily position the drug supply device 1A relative to the balloon catheter 9.

[0061] On the other hand, the inner diameter of first through-hole 4H of annular member 40 of holding member 4A is larger than the outer diameter of balloon 9B in the deflated state (see FIG. 3A). Therefore, the user can remove only balloon catheter 9 from the body while leaving drug supply device 1A inside the body, for example.

[0062] <Special Notes on the First Embodiment> The present invention is not limited to the above-described embodiment, and various modifications are possible. The target to which a drug is delivered by the drug delivery device 1A is not limited to the balloon catheter 9, and may be various other medical devices. For example, the drug delivery device 1A may be used to deliver a drug to well-known medical devices used in intravascular intervention, such as a scoring balloon catheter, a stent, a rotorabrator, or a medical excimer laser.

[0063] The drug supplied to the balloon 9B by the drug supply device 1A is not limited to a specific drug, and any known drug acting on the stenotic lesion 80 may be used. The drug supply device 1A may also release multiple drugs from the release section 3A to the balloon 9B. In this case, multiple drugs can be attached to the balloon 9B at any time and each drug can be applied to any location on the stenotic lesion 80, thereby enhancing the therapeutic effect of the stenotic lesion 80. This is preferable because it reduces various inconveniences that arise when mixing multiple drugs, compared to when multiple drugs are mixed in advance. Furthermore, by using a single drug supply device 1A, the user can apply different drugs to multiple stenotic lesions 80, respectively, thereby reducing the burden on the patient and the user. Furthermore, the user can select the type and amount of drug depending on the progress of treatment and the patient's condition. This is preferable because it allows for more proactive, real-time treatment of the stenotic lesion 80.

[0064] For example, when the stenotic lesion 80 is an intravascular calcified lesion, the drug delivery device 1A may be used as follows. The drugs used may include a cell proliferation inhibitor (such as paclitaxel or sirolimus; hereinafter referred to as the "first drug") for inhibiting thickening of the inner wall of the stenotic lesion 80 and a vascular endothelial cell migration factor (such as various growth factors or extracellular matrices; hereinafter referred to as the "second drug") for promoting early endothelialization of the inner wall of the stenotic lesion 80. Mixing the first drug, which is a low-molecular-weight drug, with the second drug, which is a proteinaceous drug, may result in aggregation or a reduction in therapeutic efficacy. In response to this, the drug delivery device 1A may be used to attach the first drug to the balloon 9B and allow it to act on the stenotic lesion 80, and then attach the second drug to the balloon 9B and allow it to act on the stenotic lesion 80. In this case, the first drug first inhibits thickening of the inner wall of the stenotic lesion 80, and then the second drug rapidly endothelializes the inner wall of the stenotic lesion 80, allowing for vascular repair. Furthermore, by applying the first drug and the second drug to the stenotic lesion 80 in stages, layers of each drug can be formed on the inner wall of the stenotic lesion 80. Furthermore, each drug can be dissolved or dispersed in a highly viscous solvent, further improving the effects of each drug.

[0065] The mechanism for enabling relative rotation between the balloon catheter 9 and the supply tube 2A may be realized by a member other than the annular member 40. For example, a cylindrical member extending in the extension direction may be used instead of the annular member 40. Note that by using a cylindrical member, the drug supply device 1A can be held more stably relative to the balloon catheter 9 than with the annular member 40.

[0066] At least a portion of the annular member 40 of the holding member 4A may be embedded in the supply tube 2A. This can improve the holding force of the supply tube 2A to the balloon catheter 9. A portion of the annular member 40 in the circumferential direction may be openable and closable. In this case, it is possible to easily attach and detach the drug supply device 1A to the balloon catheter 9. A plurality of annular members 40 may be connected to the supply tube 2A. In this case, each of the plurality of annular members 40 may be spaced apart from the adjacent annular members 40 in the extension direction. For example, the plurality of annular members 40 may be arranged at equal intervals in the extension direction.

[0067] The drug supply device 1A may be immovable in the extension direction relative to the balloon catheter 9. In this case, at least a portion of the release portion 3A may be positioned so as to always overlap with the balloon 9B in the extension direction. The release portion 3A may be immovable relative to the supply tube 2A.

[0068] In the above embodiment, the drug flowing through the lumen 30L of the passage tube 30 of the release portion 3A is supplied from the supply tube 2A in response to the pressure applied by the drug pump, and is released to the outside through the plurality of second through-holes 31. In contrast, the release portion 3A may be released to the outside through the plurality of second through-holes 31 by the interaction of magnetic force, electrostatic force, osmotic pressure, etc., instead of the force applied by the drug pump.

[0069] The release portion 3A of the drug supply device 1A contacts the expansion portion 94 of the balloon 9B in the intermediate expansion state. Alternatively, the release portion 3A may contact the expansion portion 94 of the balloon 9B in the contracted state. This allows the drug supply device 1A to attach the drug to the contracted balloon 9B.

[0070] The shape of the through holes formed in the release section 3A is not limited to being circular, like the multiple second through holes 31. For example, as shown in FIG. 5A, multiple elongated through holes 32 extending in the extension direction may be formed in the passing pipe 30 of the release section 3A. Furthermore, as shown in FIG. 5B, for example, a spirally extending through hole 33 may be formed in the passing pipe 30 of the release section 3A. Furthermore, as shown in FIG. 5C, for example, multiple elongated through holes 34 extending in the circumferential direction may be formed in the passing pipe 30 of the release section 3A. In this case, each of the through holes 34 may be shorter than the length of one circumference of the passing pipe 30.

[0071] Furthermore, the shapes of the multiple through-holes formed in the passage tube 30 may be non-uniform. For example, the release portion 3A may be formed from a material that allows the drug to permeate from the lumen 30L to the outside. For example, the release portion 3A may be made of a sponge. Note that, since a sponge has porosity, even if the release portion 3A itself is deformed by the force from the balloon 9B, the drug can be appropriately released into the balloon 9B.

[0072] The outer diameter of the deflated balloon 9B may be larger than the inner diameter of the first through-hole 4H in the annular member 40 of the holding member 4A. In this case, when the deflated balloon 9B attempts to move proximally beyond the annular member 40, the balloon 9B gets caught on the annular member 40. This makes it difficult for the balloon catheter 9 to become detached from the drug supply device 1A.

[0073] In the above example, the balloon 9B was rotated around the first rotation axis R11 (arrow Y12) while the balloon 9B was in the intermediate inflation state, and the drug was adhered to the balloon 9B. Alternatively, the drug may be adhered to the balloon 9B by rotating the drug supply device 1A around the first rotation axis R11 (arrow Y11, see FIG. 3A) while the balloon 9B is in the intermediate inflation state.

[0074] The drug supply device 1A may be used in a manner different from that shown in Figure 4. A modified method of using the drug supply device 1A will be described with reference to Figure 6.

[0075] After the drug is applied to the balloon 9B by the drug delivery device 1A (see FIG. 4B), the balloon 9B is inflated from a deflated state to a maximum inflated state at the position of the stenotic lesion 80 (see FIGS. 4C and 6A). Next, the user operates the fluid hub to remove the compressed fluid from the balloon 9B. As shown in FIG. 6B, the balloon 9B is deflated from the maximum inflated state to the deflated state.

[0076] If it is necessary to bring balloon 9B into contact with stenotic lesion 80 again to dilate blood vessel 8, the user operates proximal end 20P of drug supply device 1A to move release portion 3A distally. As shown in Fig. 6C, when release portion 3A reaches a position where it overlaps with balloon 9B in the extension direction, the user stops the movement of drug supply device 1A.

[0077] Next, as shown in FIG. 6D, the user operates the fluid hub to supply compressed fluid to the catheter shaft 9A of the balloon catheter 9. The balloon 9B expands from a deflated state to an intermediately expanded state, and the expansion portion 94 comes into contact with the release portion 3A. Next, the user rotates the balloon 9B about the first rotation axis R11 (arrow Y12). In response to the rotation of the balloon 9B, the release portion 3A also rotates about the second rotation axis R21 (arrow Y21). Next, the user operates the drug pump to supply the drug to the supply tube 2A of the drug supply device 1A. The drug is released into the balloon 9B through the multiple second through-holes 31 of the passage tube 30 of the release portion 3A. The released drug adheres to the entire circumferential area of ​​the balloon 9B.

[0078] After the drug has adhered to the entire circumferential area of ​​balloon 9B, the user operates the drug pump to stop the supply of drug to supply tube 2A. The user also stops the rotation of balloon 9B. Next, the user operates the fluid hub to remove the compressed fluid from balloon 9B. Balloon 9B contracts from the intermediate expansion state to the contracted state.

[0079] Next, as shown in Fig. 6E, the user operates the proximal end portion 20P of the drug supply device 1A to move the drug supply device 1A proximally. When the release portion 3A has moved to a position proximally separated from the stenotic lesion 80, the user stops the movement of the drug supply device 1A. Thereafter, the same operations as those described with reference to Figs. 6A and 6B are performed.

[0080] The drug supply device 1A may be integrated with the balloon catheter 9. That is, the supply tube 2A, the release portion 3A, and the holding member 4A of the drug supply device 1A may be part of the configuration of the balloon catheter 9.

[0081] <Second embodiment - medicine supply device 1B> A drug supply device 1B according to a second embodiment will be described with reference to Fig. 7. As shown in Fig. 7A, the drug supply device 1B includes a supply tube 2B, a release portion 3B, and a holding member 4B.

[0082] Supply pipe 2B has second pipe sections 203 and 204 instead of second pipe section 202 (see FIG. 1) of supply pipe 2A in drug supply device 1A. The proximal end of each of second pipe sections 203 and 204 is connected to the distal end of first pipe section 201 at bent section 21. Second pipe sections 203 and 204 extend in different directions from the connecting portion with first pipe section 201 toward the distal end. The inner lumens 20L of first pipe section 201 and second pipe sections 203 and 204 are connected to each other.

[0083] The holding member 4B has the same shape as the holding member 4A (see FIG. 1) in the medicine supply device 1A, and includes an annular member 40. The holding member 4B is provided at the bent portion 21 of the supply tube 2B. The axis that passes through the center of the first through-hole 4H of the annular member 40 and extends in the extension direction is the first rotation axis R11.

[0084] The release portion 3B has a shape that is shorter in the extension direction than the release portion 3A (see FIG. 1) of the medicine supply device 1A. The release portion 3B is held between the respective tips of the second tube portions 202 and 203. The release portion 3B extends in a direction perpendicular to the central axis C1 of the first tube portion 201 of the supply tube 2B. The release portion 3B is rotatable relative to the second tube portions 202 and 203. The rotation axis about which the release portion 3B rotates relative to the second tube portions 202 and 203 is referred to as the "second rotation axis R22." The second rotation axis R22 is perpendicular to the first rotation axis R11.

[0085] As shown in FIG. 7B , for example, a user inflates the balloon 9B to an intermediate inflation state, bringing the balloon 9B into contact with the release portion 3B, and then supplies a drug to the supply tube 2B of the drug supply device 1B. The drug is supplied to the release portion 3B via the first tube portion 201 and the second tube portions 203 and 204 and is released through the second through-holes 31 of the passage tube 30. Next, the user rotates the balloon 9B about the first rotation axis R11 (arrow Y11) while reciprocating the drug supply device 1B relative to the balloon catheter 9 in a direction along the central axis C1 of the first tube portion 201 (i.e., the extension direction) (arrow Y31). As a result, the release portion 3B, which is in contact with the balloon 9B, rotates about the second rotation axis R22 relative to the supply tube 2A (arrow Y22). The drug released from the release portion 3B adheres to the entire circumferential and extension directions of the balloon 9B.

[0086] As described above, drug supply device 1B can attach a drug to balloon 9B by moving drug supply device 1B back and forth along central axis C1 relative to balloon catheter 9. Furthermore, drug supply device 1B can attach a drug only to a desired site in the extension direction of balloon 9B, making it possible to treat stenotic lesion 80 by applying a drug only to the desired site.

[0087] The second rotation axis R22, which is the rotation axis of the release portion 3B, only needs to intersect with the first rotation axis R11, and does not have to be perpendicular to it.

[0088] <Third embodiment - medicine supply device 1C> A medicine supply device 1C according to the third embodiment will be described with reference to Fig. 8. The medicine supply device 1C includes a supply tube 2C, release portions 3C, 3D, and 3E, and a holding member 4C.

[0089] Supply pipe 2C has second pipe sections 205, 206, and 207 instead of second pipe section 202 (see FIG. 1) of supply pipe 2A in drug supply device 1A. The proximal end of each of second pipe sections 205 to 207 is connected to the distal end of first pipe section 201 at bent section 21. Second pipe sections 205 to 207 extend in different directions from the connecting portion with first pipe section 201 toward the distal end. The inner lumens 20L of first pipe section 201 and second pipe sections 205 to 207 are connected to each other.

[0090] The holding member 4C has the same shape as the holding member 4A in the medicine supply device 1A, and includes an annular member 40. The holding member 4B is provided at the bent portion 21 of the supply tube 2C. The axis that passes through the center of the first through-hole 4H of the annular member 40 and extends in the extension direction is the first rotation axis R11.

[0091] Each of the discharge sections 3C, 3D, and 3E has a passing tube 36, which is a tubular member. NiTi is used as a material for the passing tube 36, for example. The passing tube 36 has a rectangular cylindrical shape whose cross section, when cut along a plane perpendicular to the extension direction, is triangular, and has an inner cavity 36L. One of the three side surfaces of the passing tube 36 (hereinafter referred to as the "bottom surface 361") is close to a central axis C1 passing through the center of the first tube section 201. Of the three corners of the passing tube 36, corners 362, excluding the corners corresponding to both ends of the bottom surface 361, are located on the opposite side of the central axis C1 with respect to the bottom surface 361. Therefore, when the passing tube 36 is cut along a plane perpendicular to the extension direction, the cross section has a pointed shape on the side opposite to the central axis C1.

[0092] The base end of the releasing portion 3C is rotatably held at the tip end of the second pipe portion 205. The base end of the releasing portion 3D is rotatably held at the tip end of the second pipe portion 206. The base end of the releasing portion 3E is rotatably held at the tip end of the second pipe portion 207. The releasing portions 3C to 3E each extend from the base end to the tip end in parallel with the central axis C1.

[0093] An imaginary axis passing through the center of the lumen 36L of the passage tube 36 of the release portion 3C is referred to as the "second rotation axis R23." The release portion 3C is rotatable about the second rotation axis R23 relative to the supply tube 2C (arrow Y23). An imaginary axis passing through the center of the lumen 36L of the passage tube 36 of the release portion 3D is referred to as the "second rotation axis R24." The release portion 3D is rotatable about the second rotation axis R24 relative to the supply tube 2C (arrow Y24). An imaginary axis passing through the center of the lumen 36L of the passage tube 36 of the release portion 3E is referred to as the "second rotation axis R25." The release portion 3E is rotatable about the second rotation axis R25 relative to the supply tube 2C (arrow Y25). As the passage pipes 36 of the discharge sections 3C to 3E rotate about the second rotation axes R23, R24, R25, the positions of the angles 362 of the passage pipes 36 relative to the central axis C1 change.

[0094] Each of the passage tubes 36 of the release sections 3C to 3E has a plurality of second through holes 37 communicating with the inner cavity 36L. The cross-sectional shape of each of the second through holes 37 is circular. The drug flowing through the inner cavity 36L of the passage tube 36 is released to the outside through the plurality of second through holes 37 in response to the pressure applied by the drug pump.

[0095] With the catheter shaft 9A of the balloon catheter 9 inserted through the first through-hole 4H of the annular member 40 of the holding member 4C, the balloon 9B in a deflated state is positioned radially inward about the central axis C1 from each of the release portions 3C to 3E. When the balloon 9B is inflated from the deflated state to the intermediately inflated state, the inflation portion 94 of the balloon 9B comes into contact with each of the release portions 3C to 3E from the inner side in the radial direction about the central axis C1.

[0096] The method of using drug supply device 1C is the same as the method of using drug supply device 1A, and therefore the explanation will be omitted. In this case, drug supply device 1C can efficiently supply drugs to balloon 9B using release portions 3C to 3E.

[0097] It should be noted that drug supply device 1C may be used in a manner different from that of drug supply device 1A. For example, after a user applies a drug to balloon 9B using drug supply device 1C, the user may move balloon catheter 9 and drug supply device 1C distally while maintaining the balloon 9B and release portions 3C to 3E overlapping in the extension direction. When balloon 9B and release portions 3C to 3E reach stenotic lesion 80, the user may stop the movement of balloon catheter 9 and drug supply device 1C. In this state, the user may inflate balloon 9B to the maximum inflation state.

[0098] In this case, the release portions 3C to 3E are sandwiched between the stenotic lesion 80 and the balloon 9B. Note that a portion of the outer surface of the release portions 3C to 3E, more specifically, the corner 362 of the passage tube 36 of each of the release portions 3C to 3E, is sharp. Therefore, for example, when the balloon 9B is inflated to the maximum inflation state while the release portions 3C to 3E are rotated as shown in FIG. 8 , the sharp corner 362 of each of the release portions 3C to 3E sandwiched between the inflated balloon 9B and the stenotic lesion 80 will dig into the stenotic lesion 80. For example, in this state, the user supplies a drug from a drug pump and releases the drug from the release portions 3C to 3E. In this case, the drug can be appropriately applied to the portion of the stenotic lesion 80 where the release portions 3C to 3E dig into, thereby performing treatment.

[0099] In the above case, for example, by using a plurality of drugs and delivering different types of drugs to the deep part of the stenotic lesion 80, the therapeutic effect of the stenotic lesion 80 can be improved. That is, the release portions 3C to 3E can deliver the drugs to the deep part, thereby improving the ability of the balloon 9B to dilate the stenotic lesion 80. Here, the deep part of the stenotic lesion 80 refers to the part that is not exposed before dilation of the stenotic lesion 80.

[0100] In general, the causes of pathology often differ between the surface and deeper portions of stenotic lesion 80. For this reason, for example, by using different drugs to be attached to balloon 9B when dilating stenotic lesion 80 using only balloon 9B and drugs to be released from release portions 3C to 3E when dilating stenotic lesion 80 using balloon 9B and release portions 3C to 3E, it is possible to provide a drug suited to the cause of pathology, particularly in the deeper portions of stenotic lesion 80.

[0101] Specifically, for example, when the balloon catheter 9 and the drug delivery device 1C are used to treat fallopian tube stenosis, a drug (such as sitafloxacin or erythromycin) for sterilizing or bacteriostatic of the primary causative agent, chlamydia, may be used as the drug (surface therapeutic drug) attached to the balloon 9B when the stenotic lesion 80 is dilated using only the balloon 9B. Meanwhile, a drug capable of inhibiting cell proliferation (such as paclitaxel for suppressing thickening of the fallopian tube endometrium) may be used as the first-stage drug released from the release portions 3C to 3E when the stenotic lesion 80 is dilated using the balloon 9B and the release portions 3C to 3E. Furthermore, a hormone preparation (such as an estradiol derivative or a progesterone preparation) for suppressing symptoms caused by endocrine hormones may be used as the second-stage drug released from the release portions 3C to 3E when the stenotic lesion 80 is dilated using the balloon 9B and the release portions 3C to 3E.

[0102] The cross-sectional shape of the emission sections 3C to 3E is not limited to a triangle, but may be any other polygon, such as a rectangle.

[0103] The second pipe portions 205, 206, and 207 in the third embodiment are an example of the "branch portion" of the present invention.

[0104] <Fourth embodiment - medicine supply device 1D> A drug supply device 1D according to a fourth embodiment will be described with reference to Fig. 9. The drug supply device 1D includes a supply pipe 2D, a discharge portion 3F, a holding member 4D, and a shaft 5D. The supply pipe 2D, the discharge portion 3F, and the holding member 4D have the same shapes as the supply pipe 2A, the discharge portion 3A, and the holding member 4A of the drug supply device 1A, respectively. The drug supply device 1D differs from the drug supply device 1A in that it additionally includes a shaft 5D.

[0105] Shaft 5D is provided on the side surface of first pipe portion 201 of supply pipe 2D and extends along the extension direction. The length of shaft 5D in the extension direction is the same as the length of first pipe portion 201 in the extension direction. The position of base end 50P of shaft 5D coincides with base end 20P of supply pipe 2D in the extension direction. The position of tip end 50D of shaft 5D coincides with bent portion 21 of supply pipe 2D in the extension direction. Shaft 5D is harder than supply pipe 2D.

[0106] For example, by utilizing the rigidity of shaft 5D, the user can suppress bending of supply tube 2D while pushing proximal end 20P of supply tube 2D to move drug supply device 1D distally, thereby allowing the user to easily deliver release portion 3D of drug supply device 1D to stenotic lesion 80.

[0107] The shaft 5D may be provided inside the supply pipe 2D. The tip 50D of the shaft 5D may extend to the tip 20D of the supply pipe 2D. That is, the shaft 5D may be provided over the entire area of ​​the supply pipe 2D in the extension direction. [Explanation of symbols]

[0108] 1, 1A, 1B, 1C, 1D: Drug supply device 2A, 2B, 2C, 2D: Supply pipe 3A, 3B, 3C, 3D, 3E, 3F: Emission section 4A, 4B, 4C, 4D: Holding member 4H: 1st through hole 5D: Shaft 9: Balloon catheter 9A: Catheter shaft 9B: Balloon 30, 36: Passing pipe 31, 37: Second through hole 40: Annular member

Claims

1. A drug delivery device for delivering a drug to a medical device inside a patient's body, comprising: a supply tube having a tubular shape and a lumen through which the drug to be supplied from a proximal end passes; a release portion provided at a distal end portion of the supply tube opposite the proximal end portion, the release portion releasing the drug supplied to the supply tube toward the medical device; a holding member for holding the drug delivery apparatus relative to the medical device, The supply pipe is provided at a position between the base end and the tip end, The medical device and the supply tube are held in a relatively rotatable state. The holding member; Equipped with A drug supply device characterized in that a central axis passing through the center of the supply tube does not coincide with a first rotation axis, which is the rotation axis when the supply tube held by the holding member rotates relative to the medical device.

2. the holding member has an annular member having a first through hole; the first rotation axis passes through the center of the first through hole, The medicine supply device according to claim 1 , wherein the central axis does not pass through the first through-hole.

3. The holding member is 3. The drug supply device according to claim 1, wherein the medical device and the supply tube are held in a state where they can move relatively in a direction along the central axis.

4. 4. The drug supply device according to claim 1, wherein the discharge portion is rotatable relative to the supply pipe.

5. The drug supply device according to claim 4, wherein a second rotation axis, which is an axis of rotation when the release portion rotates relative to the supply pipe, extends parallel to the first rotation axis.

6. the discharge portion is rotatable relative to the supply pipe; The drug supply device according to claim 3 , wherein a second rotation axis, which is a rotation axis when the release portion rotates relative to the supply pipe, extends in a direction intersecting with the first rotation axis.

7. A plurality of the emission portions are provided, The supply pipe is 7. The drug supply device according to claim 1, wherein the tip portion has a branch portion connected to a plurality of the discharge portions.

8. 8. The drug supply device according to claim 1, further comprising a shaft that is provided along the supply pipe and is harder than the supply pipe.

9. The release section is a passage tube having a tubular shape and an inner lumen through which the drug supplied from the supply tube passes; a second through-hole provided in the passage tube, which releases the drug passing through the lumen of the passage tube to the outside; 9. The medicine supply device according to claim 1, further comprising:

10. the medical device is a balloon catheter including a catheter shaft and a balloon provided on the catheter shaft; the annular member holds the catheter shaft and the supply tube in a relatively rotatable state; 3. The drug delivery device according to claim 2, wherein the inner diameter of the annular member is larger than the outer diameter of the deflated balloon and smaller than the outer diameter of the inflated balloon.

11. the medical device is a balloon catheter including a catheter shaft and a balloon provided on the catheter shaft; the release portion releases the drug toward the balloon, 11. The drug supply device according to claim 1, wherein at least a part of the outer surface of the release portion has a pointed shape.

12. A catheter shaft; a balloon provided on the catheter shaft; A balloon catheter for delivering a drug to the balloon inside a patient's body, comprising: a supply tube having a tubular shape and a lumen through which the drug to be supplied from a proximal end passes; a release portion provided at a distal end portion of the supply tube opposite the proximal end portion, the release portion releasing the drug supplied to the supply tube toward the balloon; a retaining member for retaining the supply tube relative to the catheter shaft, The supply pipe is provided at a position between the base end and the tip end, The catheter shaft and the supply tube are held in a relatively rotatable state. The holding member; Equipped with A balloon catheter characterized in that a central axis passing through the center of the supply tube does not coincide with a first rotation axis that is a rotation axis when the supply tube held by the holding member rotates.

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