Transthyretin tetramer stabilizer, and transthyretin amyloidosis preventive or progression inhibitor.

JP7833119B2Active Publication Date: 2026-03-19KANEKA CORP +2
View PDF 5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Filing Date
2021-10-06
Publication Date
2026-03-19

AI Technical Summary

Technical Problem

Existing pharmaceuticals for stabilizing transthyretin tetramers and preventing amyloidosis have significant side effects and high costs, while preventive measures for transthyretin amyloidosis are lacking, particularly for conditions like familial amyloid polyneuropathy and senile systemic amyloidosis.

Method used

A hydrophobic extract of licorice containing licorice glabra polyphenols, specifically glabrene, glabridin, glabrol, and 4'-O-methylglabridin, is used to stabilize transthyretin tetramers, preventing their monomerization and amyloid fibril formation, formulated as tablets, capsules, or powders for oral administration.

Benefits of technology

The licorice extract effectively stabilizes transthyretin tetramers, suppressing monomerization and amyloid fibril formation, thereby preventing or inhibiting transthyretin amyloidosis, including familial amyloid polyneuropathy and senile systemic amyloidosis, with a safer and potentially lower-cost solution.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 0007833119000002
    Figure 0007833119000002
  • Figure 0007833119000003
    Figure 0007833119000003
  • Figure 0007833119000001
    Figure 0007833119000001
Patent Text Reader

Abstract

Provided are: a transthyretin tetramer stabilizing agent; and a transthyretin amyloidosis preventing agent or progression suppressing agent.　The present invention relates to a transthyretin tetramer stabilizing agent containing a Glycyrrhiza glabra hydrophobic extract that includes Glycyrrhiza-glabra glabra polyphenol, and also to a transthyretin amyloidosis preventing agent or progression suppressing agent containing a Glycyrrhiza glabra hydrophobic extract that includes Glycyrrhiza-glabra glabra polyphenol.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Traditional Chinese medicine composition for treating amyloidosis cutis

    CN103989907A

  • Traditional Chinese medicine composition for treating nephropathy of amylaidosis

    CN104587161A

  • Acute phase reactant transcription inhibition activator

    JP2007063161A

  • Tissue fibrosis screening method and Anti-tissue fibrosis agent and functional food

    JP2017096785A

  • Hepatic fibrosis inhibitor

    JP2020007236A