Biosignal measurement system

Abstract

This biological signal measurement system comprises two first electrode devices (100a), a second electrode device (100b), and a biological signal generation device (130). The first electrode device (100a)' comprises an electrode (101a), a non-inverting amplification circuit (102a), a quantization circuit (103a), a wireless transmitter (104a), an FM transmitter (105a), an FM receiver (106a), an adjustment circuit (107a), and a power source (108a). Additionally, the second electrode device (100b) comprises an electrode (101b), a non-inverting amplification circuit (102b), a quantization circuit (103b), a wireless transmitter (104b), an FM transmitter (105b), an FM receiver (106b), an adjustment circuit (107b), and a power source (108b). Additionally, the biological signal generation device (130) comprises a wireless receiver (131), a computing circuit (132), and a memory (133).

Description

Technical Field

[0001] The present invention relates to a biosignal measurement system.

Background Art

[0002] In the measurement of an electrocardiogram, which is one of the measurements of bioelectric potential, the potential difference between electrodes arranged on both the left and right sides of the human body is measured. For example, as shown in FIG. 6, a measurement system has been proposed in which a device 301 is worn on the central part of the body, and a wiring 303 is made to crawl on a compression wear 302 to provide electrodes 304 that contact the left and right waist parts (Non-Patent Document 1).

Prior Art Documents

Non-Patent Documents

[0003]

Non-Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, wearing on the body causes a great deal of discomfort due to a feeling of pressure and the trouble of wearing, resulting in a strong sense of aversion. As an alternative to the body, for example, wearing on the limbs can be considered. However, in this case, since the wiring connecting the left and right electrodes forms a loop like a handcuff, there is a strong restraint that restricts the movement of the body. If the wiring between the left and right electrodes can be cut and divided into two devices, these problems can be solved. However, the division makes it impossible to determine the reference for potential measurement, making it difficult to measure bioelectric potential.

[0005] The present invention has been made to solve the above problems, and an object thereof is to enable easy measurement of bioelectric potential even when the wiring between two electrodes is cut and divided into two devices.

Means for Solving the Problems

[0006] The biosignal measurement system according to the present invention comprises two electrode devices and a biosignal generation device, each of the two electrode devices comprising: an electrode for measuring the biopotential in the target human body; a non-inverting amplifier circuit that inputs the measured biopotential to a non-inverting amplifier terminal, amplifies it, and outputs it from an output terminal; a quantization circuit that converts the amplified signal output from the output terminal of the non-inverting amplifier circuit into digital data to generate biopotential information; a wireless transmitter that transmits the biopotential information to the biosignal generation device; an FM transmitter that converts the voltage signal output from the output terminal of the non-inverting amplifier circuit into an FM signal and transmits it to the other electrode device; and the FM signal transmitted from the other electrode device to the self-electrode device. The biosignal generation device comprises an FM receiver that receives and converts a signal into a voltage signal and outputs it, an adjustment circuit that outputs the voltage signal output from the FM receiver as an adjustment signal adjusted under set conditions to the inverting input terminal of a non-inverting amplifier circuit, and a power supply that supplies power to the non-inverting amplifier circuit, quantization circuit, wireless transmitter, FM transmitter, FM receiver, and adjustment circuit, wherein the FM signal transmitted from one of the two electrode devices to the other and the FM signal transmitted from the other to the first each have different frequencies, and the biosignal generation device comprises a wireless receiver that receives biopotential information transmitted from each of the two electrode devices, and an arithmetic circuit that generates a biosignal waveform using the biopotential information received by the wireless receiver. [Effects of the Invention]

[0007] As described above, according to the present invention, the two electrode devices and the biosignal generating device are connected by wireless communication, and the two electrode devices are connected by FM communication. Therefore, even if the wiring between the two electrodes is cut and the device is divided into two, the biopotential can be easily measured. [Brief explanation of the drawing]

[0008] [Figure 1A] Figure 1A is a diagram showing the configuration of a biosignal measurement system according to Embodiment 1 of the present invention. [Figure 1B]Figure 1B is a diagram showing a partial configuration of a biosignal measurement system according to Embodiment 1 of the present invention. [Figure 2] Figure 2 is an explanatory diagram illustrating the concept of a biosignal measurement system according to Embodiment 1 of the present invention. [Figure 3] Figure 3 is a configuration diagram showing the configuration of a biosignal measurement system according to Embodiment 2 of the present invention. [Figure 4] Figure 4 is a diagram showing the configuration of a biosignal measurement system according to Embodiment 3 of the present invention. [Figure 5] Figure 5 is a configuration diagram showing the configuration of a biosignal measurement system according to Embodiment 4 of the present invention. [Figure 6] Figure 6 is a diagram showing the configuration of a conventional biosignal measurement system. [Modes for carrying out the invention]

[0009] The following describes a biological signal measurement system according to an embodiment of the present invention.

[0010] [Embodiment 1] First, a biosignal measurement system according to Embodiment 1 of the present invention will be described with reference to Figures 1A and 1B. This system comprises two first electrode devices 100a, a second electrode device 100b, and a biosignal generation device 130.

[0011] The first electrode device 100a comprises an electrode 101a for measuring the biopotential in the target human body, a non-inverting amplifier circuit 102a that inputs the measured biopotential to a non-inverting amplifier terminal, amplifies it, and outputs it from an output terminal, a quantization circuit 103a that converts the amplified signal output from the output terminal of the non-inverting amplifier circuit 102a into digital data to generate biopotential information, and a wireless transmitter 104a that transmits the biopotential information to a biosignal generation device 130.

[0012] Furthermore, the first electrode device 100a includes an FM transmitter 105a, an FM receiver 106a, and an adjustment circuit 107a. The FM transmitter 105a converts the voltage signal output from the output terminal of the non-inverting amplifier circuit 102a into an FM signal and transmits the converted FM signal to the second electrode device 100b via the transmitting antenna 109a. The FM receiver 106a converts the FM signal transmitted from the second electrode device 100b to the first electrode device 100a and received by the receiving antenna 110a into a voltage signal and outputs it. The adjustment circuit 107a 、F The voltage signal output from the M receiver 106a is adjusted according to the set conditions and output as an adjusted signal to the inverting input terminal of the non-inverting amplifier circuit 102a.

[0013] The output of the non-inverting amplifier circuit 102a is also input to the inverting input terminal. For example, as shown in Figure 1B, if the signal input from the adjustment circuit 107a to the inverting input terminal of the non-inverting amplifier circuit 102a is Vdev2, and the output of the non-inverting amplifier circuit 102a is Vout1, then the signals are mixed in the ratio Vin- = (R+RG) / (2R+RG)Vout + (R) / (2R+RG)Vdev2 and input to the inverting input terminal of the non-inverting amplifier circuit 102a. The same applies to the non-inverting amplifier circuit 102b, which will be described later.

[0014] Furthermore, the first electrode device 100a includes a power supply 108a that supplies power to the non-inverting amplifier circuit 102a, the quantization circuit 103a, the wireless transmitter 104a, the FM transmitter 105a, the FM receiver 106a, and the adjustment circuit 107a.

[0015] The second electrode device 100b comprises, first, an electrode 101b for measuring the biopotential in the target human body; a non-inverting amplifier circuit 102b that inputs the measured biopotential to a non-inverting amplifier terminal, amplifies it, and outputs it from an output terminal; a quantization circuit 103b that converts the amplified signal output from the output terminal of the non-inverting amplifier circuit 102b into digital data to generate biopotential information; and a wireless transmitter 104b that transmits the biopotential information to a biosignal generation device 130.

[0016] Also, the second electrode device 100b includes an FM transmitter 105b, an FM receiver 106b, and an adjustment circuit 107b. The FM transmitter 105b converts the voltage signal output from the output terminal of the non-inverting amplifier circuit 102b into an FM signal, and transmits the converted FM signal to the first electrode device 100a by the transmission antenna 109b. The FM receiver 106b converts the FM signal transmitted from the first electrode device 100a to the second electrode device 100b and received by the reception antenna 110b into a voltage signal and outputs it. The adjustment circuit 107b outputs the voltage signal output from the FM receiver 106b as an adjustment signal adjusted under the set conditions to the inverting input terminal of the non-inverting amplifier circuit 102b.

[0017] Also, the second electrode device 100b includes a power supply 108b that supplies power to the non-inverting amplifier circuit 102b, the quantization circuit 103b, the wireless transmitter 104b, the FM transmitter 105b, the FM receiver 106b, and the adjustment circuit 107b.

[0018] Here, the FM signal transmitted from the first electrode device 100a to the second electrode device 100b and the FM signal transmitted from the second electrode device 100b to the first electrode device 100a have different frequencies respectively.

[0019] The biological signal generation device 130 includes a wireless receiver 131 that receives the biological potential information transmitted from each of the first electrode device 100b and the second electrode device 100b, and an arithmetic circuit 132 that generates a biological signal waveform using the biological potential information received by the wireless receiver 131. The arithmetic circuit 132 can generate an electrocardiogram signal waveform, for example, using two pieces of biological potential information transmitted from each of the first electrode device 100b and the second electrode device 100b attached to any two of the four limbs of the human body. The biological signal generation device 130 also includes a memory 133 that stores the biological signal waveform generated by the arithmetic circuit 132.

[0020] Figure 2 shows the concept of the biosignal measurement system according to Embodiment 1. For example, when measuring an electrocardiogram as a biosignal and generating an electrocardiogram, it is necessary to place multiple electrodes in a positional relationship that surrounds the heart. For this reason, a measurement site that is comfortable for the human body 140 is to attach the first electrode device 100a and the second electrode device 100b to at least two locations on the limbs, such as the hands and feet. By adopting this mounting configuration of the first electrode device 100a and the second electrode device 100b, the feeling of pressure and discomfort caused by wearing clothing can be greatly reduced. Furthermore, the measurement target of this biosignal measurement system is not limited to electrocardiograms, but can also be applied to the measurement of electromyography and electroencephalography. By applying it, the discomfort of wiring is eliminated, the degree of freedom in electrode placement is increased, and the range of devices that can be implemented is expected to be broadened.

[0021] In this example, the non-inverting amplifier circuit 102a of the first electrode device 100a and the non-inverting amplifier circuit 102b of the second electrode device 100b are coupled together. Since this configuration is similar to that of an oscillator circuit, the phase rotation and amplification caused by the delay of the coupled signals will cause oscillation if the phase rotation is 180 degrees and the amplification is 1 or greater.

[0022] For example, when constructing a non-inverting amplifier circuit with a bandwidth of DC to 1kHz, which is typical for biological signals, a delay of 0.1ms results in a 36-degree phase rotation for a 1kHz signal. In other words, a delay of 0.5ms results in a 180-degree phase rotation, so the possibility of oscillation cannot be ruled out. For this reason, in the coupling of the non-inverting amplifier circuit 102a and the non-inverting amplifier circuit 102b described above, it is necessary to minimize the delay in the part that couples the voltage signal.

[0023] Next, electrodes 101a and 101b will be described. Various types of electrodes can be used for these electrodes, including Ag / AgCl electrodes used in medical applications, conductive cloth electrodes, metal electrodes, and any other suitable material. In particular, by using cloth or metal electrodes that do not need to adhere to the human body and creating a non-contact electrode configuration in which the sensor device can be attached over clothing, usability can be further enhanced. For non-contact electrode configurations, capacitive coupling is particularly preferable because it allows for easier transmission of high-frequency signals.

[0024] Next, adjustment circuits 107a and 107b will be described. Faith FM signal of Since this section primarily performs adjustments by a constant factor, it can be constructed using operational amplifiers. While it is possible to construct it using multiple operational amplifiers connected in stages, the delay accumulates with each additional stage, making it prone to instability. For this reason, it is preferable to construct each of the adjustment circuits 107a and 107b from a single operational amplifier, which is the minimum configuration.

[0025] Next, we will describe the non-inverting amplifier circuits 102a and 102b. Since bioelectric potential is a very weak signal, signal amplification is necessary using non-inverting amplifier circuits 102a and 102b, which are composed of filter circuits and operational amplifier amplification circuits. In particular, by using non-inverting amplifier circuits, it is possible to achieve a system configuration equivalent to an instrumentation amplifier with high common-mode suppression capability.

[0026] Furthermore, while high input impedance is required in the amplification stages of non-inverting amplifier circuits 102a and 102b to reduce bioelectric potential loss, the noise does not increase significantly even with a high input impedance configuration. On the other hand, in inverting amplifier circuits, the resistor that determines the input impedance also affects the gain setting and contributes directly as thermal noise, thus reducing the signal-to-noise ratio. For this reason, non-inverting amplifier circuits are effective.

[0027] In biopotential measurement, the potential difference between two electrodes is detected, so the same reference potential is required in non-inverting amplifier circuits 102a and 102b. Therefore, by using the potential generated by adjustment circuits 107a and 107b, balanced signal amplification becomes possible between the two first electrode devices 100a and the second electrode device 100b, ultimately yielding good biosignal information.

[0028] Furthermore, the FM communication frequencies used to couple the non-inverting amplifier circuit 102a and the non-inverting amplifier circuit 102b must be different. This is because using the same frequency would cause mutual interference, preventing the desired coupling from being achieved. This is equivalent to dividing the bandwidth in communication, and by increasing the frequency used, the present invention can be used not only with a pair of electrode devices but also with a larger number of electrode devices.

[0029] Next, the wireless transmitters 104a and 104b will be described. For example, the wireless transmitter 104a can be composed of a single communication module, and it is sufficient if it can be connected in such a way that it can receive the measured potential output from the quantization circuit 103a and transmit it to the biosignal generation device 130.

[0030] The wireless communication network 150 between the wireless transmitters 104a and 104b and the wireless receiver 131 can use any standard, such as carrier communication, Wi-Fi (registered trademark), or Bluetooth (registered trademark) (Figure 2). The transmitter and receiver must be selected according to the communication standard. For short-range communication standards such as Bluetooth, a smartphone or other device close to the user (the human body being measured) can be used as the biosignal generator 130. Alternatively, if Wi-Fi or similar standards are used, a server can be used as the biosignal generator 130.

[0031] Furthermore, the function required of the biosignal generator 130 is to receive signals from multiple electrode devices and calculate the target biopotential. These functions can be implemented (built into) any of the electrode devices without using the biosignal generator 130 (Figure 3). In this case, as illustrated in Figure 3, the second electrode device 100b is equipped with a wireless receiver 104b' and a biosignal generator 130a equipped with a calculation circuit 132 and memory 133 is added.

[0032] The wireless receiver 104b' of the second electrode device 100b receives biopotential information transmitted from the first electrode device 100a and calculates the biopotential by combining it with the biopotential information of the second electrode device 100b. The calculated biopotential is stored in the memory 133 of the second electrode device 100b, enabling it to perform the same functions and effects as described above. In addition, this configuration does not require a separate biosignal generator 130, eliminating the need to carry a smartphone or other device, thus enabling more user-unrestricted measurements.

[0033] [Embodiment 2] Next, a biosignal measurement system according to Embodiment 2 of the present invention will be described with reference to Figure 4. This system comprises two first electrode devices 100a', a second electrode device 100b', and a biosignal generation device 130.

[0034] The first electrode device 100a' comprises an electrode 101a, a non-inverting amplifier circuit 102a, a quantization circuit 103a, a wireless transmitter 104a, an FM transmitter 105a, an FM receiver 106a, an adjustment circuit 107a, and a power supply 108a. The second electrode device 100b ’ The device comprises an electrode 101b, a non-inverting amplifier circuit 102b, a quantization circuit 103b, a wireless transmitter 104b, an FM transmitter 105b, an FM receiver 106b, an adjustment circuit 107b, and a power supply 108b. The biosignal generation device 130 comprises a wireless receiver 131, an arithmetic circuit 132, and a memory 133. These configurations are the same as those of the previously described Embodiment 1.

[0035] In Embodiment 2, FM communication is performed using the human body as a communication channel. The FM transmitter 105a converts the voltage signal output from the output terminal of the non-inverting amplifier circuit 102a into an FM signal, and the converted FM signal is transmitted via the transmitting electrode 109a' to the second electrode device 100b using the human body as a channel. ’ It transmits to the FM receiver 106a, second electrode device 100b ’ From the first electrode device 100a ’ The FM signal, transmitted using the human body as a channel and received by the receiving electrode 110a', is converted into a voltage signal and output.

[0036] Furthermore, the FM transmitter 105b converts the voltage signal output from the output terminal of the non-inverting amplifier circuit 102b into an FM signal, and transmits the converted FM signal to the first electrode device 100a using the human body as a channel via the transmitting electrode 109b'. The FM receiver 106b transmits to the first electrode device 100a ’ From the second electrode device 100b ’ The FM signal, transmitted using the human body as a channel and received by the receiving electrode 110b', is converted into a voltage signal and output.

[0037] As described above, performing FM communication via the human body has the advantages of reducing delay and power consumption, and because the human body functions as a waveguide, radio waves can be confined, making it resistant to external interference and further reducing the risk of causing external interference. Even when transmitting through the human body, the first electrode device 100a ’ From the second electrode device 100b ’ The FM signal transmitted to and the second electrode device 100b ’ From the first electrode device 100a ’ The FM signals transmitted to each device will have different frequencies. By using a frequency band of several MHz to approximately 100 MHz, considering the electrical properties of the human body, losses can be minimized.

[0038] Furthermore, in this example, the first electrode device 100a' uses three electrodes: electrode 101a, transmitting electrode 109a', and receiving electrode 110a'. However, since each electrode has a different frequency, it is possible to configure it with a single electrode by providing a bandpass filter, which reduces the number of parts that come into contact with the human body and thus improves user comfort.

[0039] [Embodiment 3] Next, a biosignal measurement system according to Embodiment 3 of the present invention will be described with reference to Figure 5. This system comprises two first electrode devices 100a'', a second electrode device 100b'', and a biosignal generation device 130.

[0040] In Embodiment 3, the FM transmitter is composed of voltage-controlled oscillators (VCO105a', VCO105b'), and the FM receiver is composed of phase-locked circuits (PLL106a', PLL106b'). The other configurations are the same as in Embodiment 2 described above.

[0041] As shown in Embodiment 2, in a configuration that realizes FM communication using the human body as a communication channel, delay parameters may fluctuate significantly. For this reason, it is necessary to use devices that have particularly low delay during transmission and reception within FM communication. As an example, first, the FM transmitter is configured from a voltage-controlled oscillator to directly modulate the output frequency with voltage. In addition, the FM receiver is configured from a phase-locked circuit and uses a direct detection method.

[0042] When the human body is used as a communication channel, a high signal-to-noise ratio (SNR) can be expected due to the confinement effect of radio waves. Therefore, when using the human body as a channel, it is more effective to use a configuration with low delay than to use highly accurate demodulation. By configuring the FM transmitter from a voltage-controlled oscillator and the FM receiver from a phase-locked circuit, delay can be effectively reduced.

[0043] By the way, while delay can be reduced by constructing the FM transmitter from a voltage-controlled oscillator and the FM receiver from a phase-locked circuit, when direct detection and direct modulation are employed, it is essential for low-error communication that the voltage-to-frequency conversion characteristics of the voltage-controlled oscillator constituting the FM transmitter and the voltage-controlled oscillator included in the phase-locked circuit constituting the FM receiver match. However, voltage-controlled oscillators generally use LC resonance with a variable capacitance diode called a varactor, or oscillation using a ring oscillator. Due to manufacturing variations in these components, there are cases where the voltage-to-frequency conversion characteristics of the voltage-controlled oscillator constituting the FM transmitter and the voltage-controlled oscillator included in the phase-locked circuit constituting the FM receiver do not match.

[0044] As an example of a case where the voltage-to-frequency conversion characteristics do not match, such as when the center frequencies do not match, adjustment is possible by adding an offset to the operational amplifier in the adjustment circuit so that the voltage-frequency characteristics of the voltage-controlled oscillator constituting the FM transmitter of the other electrode device and the voltage-controlled oscillator of the phase-locked circuit of the own electrode device match. For example, the offset can be determined by the input voltage to the operational amplifier. In this way, adjustment can be made without increasing the delay when FM communication is employed.

[0045] Furthermore, in cases where the voltage-to-frequency conversion characteristics do not match, such as when the slopes of the voltage-frequency characteristics do not match, it is possible to adjust the voltage-frequency characteristics of the operational amplifier in the adjustment circuit without increasing the delay by monitoring the respective oscillation frequency characteristics and adjusting the amplification conditions of the operational amplifier in the adjustment circuit so that the voltage-frequency characteristics of the voltage-controlled oscillator constituting the FM transmitter of the other electrode device and the voltage-controlled oscillator of the phase-locked circuit of the own electrode device match. For example, the amplification conditions of the operational amplifier can be adjusted by making the resistance value of the operational amplifier variable.

[0046] As described above, by appropriately adjusting the conditions of the operational amplifier in the adjustment circuit, it is possible to overcome the weaknesses of FM communication using a voltage-controlled oscillator and a phase-locked circuit. In particular, when using the human body as a communication channel, the above configuration is preferable.

[0047] As described above, according to the present invention, the two electrode devices and the biosignal generating device are connected by wireless communication, and the two electrode devices are connected by FM communication. Therefore, even if the wiring between the two electrodes is cut and the device is divided into two, the biopotential can be easily measured.

[0048] It should be noted that the present invention is not limited to the embodiments described above, and it is clear that many modifications and combinations can be implemented within the technical concept of the present invention by those with ordinary skill in the art. [Explanation of symbols]

[0049] 100a...First electrode device, 100b...Second electrode device, 101a,101b...Electrodes, 102a,102b...Non-inverting amplifier circuit, 103a,103b...Quantization circuit, 104a,104b...Wireless transmitter, 105a,105b...FM transmitter, 106a,106b...FM receiver, 107a,107b...Adjustment circuit, 108a,108b...Power supply, 109a,109b...Transmitting antenna, 110a,110b...Receiving antenna, 130...Biosignal generator, 131...Wireless receiver, 132...Arithmetic circuit, 133...Memory.

Claims

1. It comprises two electrode devices and a biosignal generation device, Each of the two electrode devices is Electrodes for measuring bioelectric potential in the target human body, An amplification circuit comprising a non-inverting input terminal, an inverting input terminal, and an output terminal, which amplifies the biopotential input to the non-inverting input terminal via the electrodes and outputs the amplified signal from the output terminal, A quantization circuit that converts the amplified signal output from the output terminal of the amplification circuit into digital data to generate biopotential information, A wireless transmitter that transmits the biopotential information to the biosignal generating device, An FM transmitter that converts the amplified signal output from the output terminal of the amplification circuit into an FM signal and transmits it to the other electrode device, An FM receiver that receives the other FM signal transmitted from the other electrode device, converts the received other FM signal into a voltage signal, and outputs it; An adjustment circuit that adjusts the voltage signal output from the FM receiver under set conditions, and outputs the voltage signal adjusted under the set conditions as an adjustment signal for adjusting by a constant multiple to the inverting input terminal of the amplification circuit, A power supply that provides power to the amplification circuit, the quantization circuit, the wireless transmitter, the FM transmitter, the FM receiver, and the adjustment circuit. Equipped with, The FM signal transmitted from one of the two electrode devices to the other, and the FM signal transmitted from the other to the first, each have different frequencies. The aforementioned biosignal generating device is A wireless receiver that receives the biopotential information transmitted from each of the two electrode devices, The wireless receiver has a calculation circuit that generates a biosignal waveform using the biopotential information it receives. A biosignal measurement system characterized by having the following features.

2. In the biological signal measurement system according to claim 1, A biosignal measurement system characterized in that FM communication between the FM transmitter and the FM receiver is performed using the human body as the communication channel.

3. In the biological signal measurement system according to claim 1, One of the two electrode devices incorporates the biosignal generating device. A biosignal measurement system characterized by the following features.

4. In the biological signal measurement system according to claim 1, The calculation circuit generates an electrocardiogram waveform using two biopotential information signals transmitted from each of the two electrode devices attached to any two locations on the limbs of the human body. A biosignal measurement system characterized by the following features.

5. In the biosignal measurement system according to any one of claims 1 to 4, The FM transmitter is composed of a voltage-controlled oscillator. The aforementioned FM receiver is composed of a phase-locking circuit. A biosignal measurement system characterized by the following features.

6. In the biosignal measurement system according to claim 5, The adjustment circuit includes an operational amplifier and performs at least one of the following: changing the amplification conditions of the operational amplifier and adding an offset to the operational amplifier, so that the voltage-frequency characteristics of the voltage-controlled oscillator of the other electrode device and the voltage-frequency characteristics of the voltage-controlled oscillator section of the phase-locked circuit of the self-electrode device match each other. A biosignal measurement system characterized by the following features.

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