Sensor units and measuring instruments

Abstract

To provide a measurement system configured to comprise a sensor unit and a measuring instrument separately, improving reproducibility of a measurement result by stabilizing sensor sensitivity.SOLUTION: A sensor unit configured to be attachable / detachable with respect to a measuring instrument for executing electrochemical measurement, comprises a first cell for temporarily storing a test liquid supplied from the outside, and a second cell including a sensor electrode, where the sensor unit is so configured that the supply of the test liquid from the inside of the first cell to the inside of the second cell is triggered by attachment of the sensor unit to the measuring instrument.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a sensor unit and a measuring instrument.

Background Art

[0002] There is known a measurement system that performs a voltage sweep operation or the like on a sensor electrode in contact with a test liquid such as body fluid to advance a predetermined reaction and measures the concentration of a specific component contained in the liquid. In particular, in recent years, for the purpose of improving convenience and the like, research and development of a system in which a sensor unit having a sensor electrode and a measuring instrument that applies a voltage (sweep or the like) to the sensor electrode are configured separately has been promoted (see, for example, Patent Document 1 and Patent Document 2).

[0003] This separate system has various advantages for users, such as being excellent in handling because the sensor unit is configured to be detachable from the measuring instrument, facilitating the replacement and disposable use of the sensor unit, expecting cost reduction of the sensor unit by mass production, and enabling multiple people to share the measuring instrument.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, in the system described above, measurement by the measuring instrument does not necessarily begin immediately after the test solution is brought into contact with the sensor unit. After contact with the test solution, the sensor unit may be left unattended for several minutes to several hours before measurement by the measuring instrument is performed. When the sensor electrode is left unattended with the test solution attached in this manner, components in the test solution (e.g., proteins) can adhere to the working surface of the sensor electrode, causing significant fluctuations in sensor sensitivity. Furthermore, the amount of this sensitivity fluctuation can vary greatly depending on the unattended time and environmental conditions. For these reasons, stabilizing sensor sensitivity and improving the reproducibility of measurement results have become newly apparent challenges in the separate-unit measurement system described above.

[0006] The present invention has been made in view of the above problems, and aims to provide a technology for stabilizing sensor sensitivity and improving the reproducibility of measurement results in a measurement system in which a sensor unit equipped with a sensor electrode and a measuring instrument that performs electrochemical measurements on the sensor unit are configured separately. [Means for solving the problem]

[0007] One aspect of the present invention is, A sensor unit configured to be detachable from a measuring instrument for performing electrochemical measurements, A first cell that temporarily stores the test fluid supplied from an external source, It comprises a second cell containing a sensor electrode, A sensor unit configured such that the supply of the test fluid from the first cell to the second cell is triggered by the attachment of the sensor unit to the measuring instrument. [Effects of the Invention]

[0008] According to the present invention, in a measurement system in which a sensor unit and a measuring instrument that performs electrochemical measurements on the sensor unit are configured separately, the sensor sensitivity can be stabilized and the reproducibility of the measurement results can be improved. [Brief explanation of the drawing]

[0009] [Figure 1] Figure 1(a) is a schematic diagram showing the configuration of a measurement system according to one embodiment of the present invention, and (b) is a schematic diagram for explaining the attachment and detachment of a sensor unit. [Figure 2] Figure 2(a) is a top view showing the configuration of a sensor unit according to one embodiment of the present invention, and (b) is a cross-sectional view thereof. [Figure 3] Figure 3(a) shows the sensor unit in Figure 2(a) with the test fluid stored inside, and (b) shows the sensor unit attached to the measuring instrument. [Figure 4] Figure 4(a) shows the sensor unit according to another embodiment of the present invention when the test fluid is stored in it, and (b) shows it when it is attached to a measuring instrument. [Figure 5] Figure 5(a) shows the sensor unit according to another embodiment of the present invention when the test fluid is stored in it, and (b) shows it when it is attached to a measuring instrument. [Figure 6] Figure 6(a) shows the sensor unit according to another embodiment of the present invention when the test fluid is stored in it, and (b) shows it when it is attached to a measuring instrument. [Figure 7] Figure 7(a) shows the sensor unit according to another embodiment of the present invention when the test fluid is stored in it, and (b) shows it when it is attached to a measuring instrument. [Figure 8] Figure 8 shows a sensor unit according to another embodiment of the present invention when the test liquid is stored in it. [Figure 9] Figure 9 shows a sensor unit according to another embodiment of the present invention when the test liquid is stored in it. [Figure 10] Figure 10 shows a sensor unit according to another embodiment of the present invention when the test liquid is stored in it. [Figure 11] Figure 11 is a perspective view showing the configuration of a sensor unit according to another embodiment of the present invention. [Figure 12]FIG. 12 is a schematic diagram for explaining the case where the measurement system is introduced into a toilet.

Embodiments for Carrying Out the Invention

[0010] <One Embodiment of the Present Invention> Hereinafter, one embodiment of the present invention will be described. Hereinafter, the measurement system, the sensor unit, and the measuring instrument of the present embodiment will be described respectively.

[0011] (1) System Configuration As shown in FIG. 1(a) for example, the measurement system 1 of the present embodiment includes a sensor unit 100, a measuring instrument 200, and a determination support device 300. The measurement system 1 is configured to be able to measure the concentrations and the like of various components (specific substances, test substances) contained in the test liquid, and output determination result data and the like indicating the health state of the subject based on the results.

[0012] The test liquid is not particularly limited, and examples thereof include various body fluids such as urine, saliva, sputum, nasal discharge, tears, sweat, and blood. When the test liquid is urine, examples of the specific substances include urea, ammonia, creatinine, uric acid, amino acids, ascorbic acid, phosphorus, oxalic acid, nitrite, sodium, potassium, calcium, protein, urine sugar, ketone bodies, bilirubin, urobilinogen, cytokines, cortisol, red blood cells, white blood cells, platelets, and the like.

[0013] (Sensor Unit) As shown in Fig. 1(b), the sensor unit 100 is portable and can be carried by hand by the subject, and is configured to be detachable from the measuring instrument 200. As will be described later, when the test liquid is poured off while the sensor unit 100 is detached from the measuring instrument 200, the sensor unit 100 is configured to isolate the test liquid from the sensor electrode 40 while storing the test liquid. On the other hand, when the sensor unit 100 is attached to the measuring instrument 200, it is configured to bring the test liquid into contact with the sensor electrode 40 with the attachment as a trigger. In this specification, the structure in which the test liquid comes into contact with the sensor electrode 40 when the sensor unit 100 is attached to the measuring instrument 200 is called a trigger structure.

[0014] Here, the sensor unit 100 will be specifically described with reference to Figs. 2 and 3. Here, the case where the sensor unit 100 includes a vent tube 60 as a trigger mechanism will be described as an example. Fig. 2(a) is a top view showing the schematic configuration of the sensor unit according to an embodiment, and Fig. 2(b) is a cross-sectional view thereof. Fig. 3(a) is a view when the test liquid is poured onto the detached sensor unit, and Fig. 3(b) is a view of the sensor unit attached to the measuring instrument.

[0015] As shown in Fig. 2(a), the sensor unit 100 mainly includes a base material 10, a first cell 20 provided on one main surface of the base material 10, a second cell 30, a sensor electrode 40 encapsulated in the second cell 30, a flow path 50 that connects the inside of the first cell 20 and the inside of the second cell 30, and a vent tube 60 that is connected to the second cell 30 and acts as a trigger structure. Note that Fig. 2(a) shows the case where the first cell 20, the second cell 30, the flow path 50, the vent tube 60, etc. are provided on the same main surface, but they may be provided on different main surfaces.

[0016] Of the two main surfaces of the base material 10, one main surface is configured to support the first cell 20, the second cell 30, the sensor electrode 40, the flow path 50, and the vent tube 60. The base material 10 is formed of a sheet-like or plate-like member and has a longitudinal shape.

[0017] The substrate 10 has sufficient physical (mechanical) strength to function as a sensor unit 100, such as strength to prevent bending or breakage even when exposed to a test fluid (urine). The substrate 10 is formed from an insulating material. Examples of insulating materials include plastic, glass epoxy resin, ceramic, and glass. For example, the substrate 10 can be a rigid substrate or a flexible substrate.

[0018] The size of the base material 10 is not particularly limited, but its length can be, for example, 20 mm or more and 115 mm or less. Its width can be, for example, 6 mm or more and 30 mm or less.

[0019] A first cell 20 for storing the test fluid is provided on one end of the main surface of the base material 10. The first cell 20 is made of a water-resistant and insulating material such as plastic, and is configured as a hollow cylindrical shape with a rectangular cross-section. The internal space of the first cell 20 becomes the space for storing the test fluid. The first cell 20 is provided with an intake port 21. This intake port 21 is of a size necessary and sufficient for taking in the test fluid, and when the test fluid is poured into the first cell 20, it becomes the port for taking in the test fluid into the internal space.

[0020] A second cell 30 is provided on the main surface of the base material 10, spaced apart from the first cell 20. The sensor electrode 40 is enclosed within the second cell 30. The second cell 30 is configured such that the inflow of the test fluid is suppressed when it is detached from the measuring instrument 200, but the test fluid flows into it when it is attached to the measuring instrument 200. The internal space of the second cell 30 stores the test fluid flowing in from the first cell 20 and becomes a space that generates an electrochemical reaction through contact between the sensor electrode 40 and the test fluid. Like the first cell 20, the second cell 30 is made of a water-resistant and insulating material such as plastic, and is configured as a hollow cylindrical shape with a rectangular cross-section so as to enclose the sensor electrode 40.

[0021] From the viewpoint of ensuring more reliable contact between the sensor electrode 40 and the test solution within the second cell 30, it is preferable that the volume of the second cell 30 is smaller than the volume of the first cell 20.

[0022] A flow path 50 is provided between the first cell 20 and the second cell 30, connecting the spaces between them. The flow path 50 is configured to allow the test fluid to flow from the first cell 20 to the second cell 30 via a trigger structure. The flow path 50 is not particularly limited as long as it can carry the test fluid; for example, a plastic tube can be used. As shown in Figure 3(a), the opening of the flow path 50 on the first cell 20 side is positioned to be immersed in the test fluid S stored in the first cell 20.

[0023] From the viewpoint of allowing the test fluid S to flow into the second cell 30 by capillary action, it is preferable that the flow path 50 has a shape that generates capillary action. For example, the inner diameter of the flow path 50 is preferably narrow enough to generate capillary action, specifically between 1 mm and 10 mm. Furthermore, the length of the flow path 50 is preferably long enough to allow the test fluid to be drawn up from the first cell 20 to the second cell 30 by capillary action, specifically between 3 mm and 20 mm.

[0024] The sensor electrode 40 generates an electrochemical reaction upon contact with the test solution S and is enclosed within the second cell 30. For example, the sensor electrode 40 can consist of a working electrode, a counter electrode, and a reference electrode. The material of the working electrode can be appropriately selected depending on the type of specific component being measured. For example, the working electrode can be an electrode made of silver (Ag), gold (Au), platinum (Pt), or copper, a carbon electrode, or a conductive diamond electrode doped with boron (B). A functional film containing an enzyme or antibody that promotes the electrochemical reaction may be immobilized on the surface of the working electrode. The counter electrode is not particularly limited as long as it is a conductive electrode, and the same material as the working electrode can be used. For example, a silver / silver chloride (Ag / AgCl) electrode can be used as the reference electrode. Note that the sensor electrode 40 is not limited to the three-electrode configuration shown in Figure 2(a), but may also be a two-electrode configuration, for example, comprising a working electrode and a counter electrode that also serves as a reference electrode.

[0025] Wiring 41 is connected to the sensor electrode 40. Wiring 41 is positioned to connect to a connection terminal 42 located on the opposite side of the sensor unit 100 from the first cell 20. The sensor unit 100 can be electrically connected by inserting the side with the connection terminal 42 into, for example, the input port of a measuring instrument 200.

[0026] The wiring 41 can be formed using metals such as copper (Cu) or aluminum (Al). The wiring 41 can be formed, for example, using a subtractive method in which unnecessary portions of a copper film pre-applied to the substrate 10 that are not covered by the resist are removed by etching to form the required conductor pattern. These conductor patterns formed using the subtractive method may also be plated with, for example, gold (Au) or silver (Ag). Alternatively, the wiring 41 can be formed by screen printing, in which case silver or carbon-based wiring can be formed.

[0027] (Measuring instrument) The measuring instrument 200 is configured to be connectable to the sensor unit 100, and the sensor unit 100 is configured to measure the electrochemical reaction that occurs when the sensor electrode 40 comes into contact with the test liquid S. For example, the measuring instrument 200 is configured to perform a predetermined voltage sweep scan on the sensor electrode 40 to electrolyze a specific component contained in the test liquid, and to measure the concentration of the specific component from the magnitude of the reaction that occurs. Alternatively, for example, the measuring instrument 200 is configured to measure the concentration of a specific component from the amount of voltage fluctuation (electromotive force) or current fluctuation caused by the electrochemical reaction on the surface of the sensor electrode 40. In this embodiment, as shown in Figure 3(b), the measuring instrument 200 has an insertion port for the sensor unit 100 and is equipped with a needle-shaped member 210 in a position that causes the vent tube 60 to break when the sensor unit 100 is inserted.

[0028] Preferably, the measuring instrument 200 is configured to initiate electrochemical measurement triggered by the attachment of the sensor unit to the measuring instrument. This allows for rapid measurement of the electrochemical reaction caused by contact between the test solution S and the sensor electrode 40 as soon as the test solution S begins to flow from the first cell 20 to the second cell 30. As a result, fluctuations in sensor sensitivity can be avoided, and the reproducibility of the measurement results can be improved.

[0029] Preferably, the measuring instrument 200 is configured to start the electrochemical measurement after a predetermined time has elapsed following the attachment of the sensor unit 100 to the measuring instrument 200. After the attachment of the sensor unit 100, the test liquid S begins to flow into the second cell 30, and after a predetermined time has elapsed, the second cell 30 is filled with a predetermined amount of the test liquid S, and the flow of the test liquid S reaches a steady state. By performing the electrochemical measurement in this state, the reproducibility of the measurement results can be further improved.

[0030] Furthermore, the measuring instrument 200 is configured to transmit data indicating the concentration of specific components obtained by the above-mentioned measurement to the judgment support device 300 via wireless communication means, wired communication means, etc.

[0031] (Judgment support device) The judgment support device 300 is configured as a computer (smartphone, tablet, PC, etc.) equipped with a CPU, RAM, storage, output function, and communication function. The judgment support device 300 is configured to output judgment result data, which indicates the subject's health status, to the subject or other information processing device based on concentration data received at predetermined timings.

[0032] (2)Measurement method Next, the measurement method in the measurement system 1 described above will be explained using Figure 12. Figure 12 is a schematic diagram showing the measurement system for the test fluid inside a toilet. In Figure 12, the case in which the measuring instrument 200 and the judgment support device 300 are installed on the wall 400a of the toilet 400 is illustrated as an example.

[0033] First, the subject prepares the sensor unit 100. The subject, for example, brings the sensor unit 100 into the toilet 400, or picks up the sensor unit 100 that is already installed in the toilet 400. Next, the subject grasps the connection terminal 42 side of the sensor unit 100 at the toilet bowl 410, for example as shown in Figure 2(a) or Figure 2(b), and pours the test fluid S (for example, urine) towards the first cell 20. As a result, as shown in Figure 3(a), the test fluid S flows into the first cell 20 from the intake port 21. At this stage, the vent pipe 60 is not opened, and the inside of the second cell 30 is airtight. Therefore, the test fluid S does not flow into the second cell 30, but remains in the first cell 20. The subject continues to pour the test fluid S until a predetermined amount of test fluid S is stored in the first cell 20.

[0034] Next, after a predetermined amount of the test fluid S has been stored in the first cell 20, the subject inserts the sensor unit 100, with its connection terminal 42 side, into the insertion port of the measuring instrument 200, and attaches it to the measuring instrument 200. At this time, as shown in Figure 3(b), due to structural interference between the sensor unit 100 and the needle-shaped member 210 of the measuring instrument 200, one end of the vent pipe 60 is ruptured and opened. This releases the airtight seal of the vent pipe 60, allowing the atmosphere inside the second cell 30 to escape to the outside. As a result, the test fluid S stored in the first cell 20 flows into the second cell 30 via the flow path 50 by capillary action. Inside the second cell 30, the test fluid S and the sensor electrode 40 come into contact, and an electrochemical reaction occurs.

[0035] Meanwhile, the measuring instrument 200 performs a predetermined voltage sweep scan on the sensor electrode 40 to electrolyze specific components contained in the test solution S, and measures the concentration of the specific components from the magnitude of the reaction that occurs.

[0036] The judgment support device 300 outputs judgment result data, etc., that suggests the subject's health status, based on the measurement data from the measuring instrument 200.

[0037] As described above, subjects can obtain measurement results using the sensor unit 100 inside the toilet 400.

[0038] (3) Effects according to this embodiment This embodiment provides one or more of the following effects.

[0039] (a) The sensor unit 100 of this embodiment is configured separately from the measuring instrument 200. Before being attached to the measuring instrument 200, when the test fluid S is poured over it, the test fluid S is allowed to flow into and be stored in the first cell 20, but the test fluid S is not allowed to flow into the second cell 30 which contains the sensor electrode 40. This temporarily suppresses contact between the collected test fluid S and the sensor electrode 40. Therefore, even if time has passed between the collection of the test fluid S and the measurement, it is possible to suppress fluctuations in sensor sensitivity due to components in the test fluid S adhering to the sensor electrode 40. Furthermore, the sensor unit 100 includes a flow path 50 that connects the first cell 20 and the second cell 30, and a vent pipe 60 connected to the second cell 30 to release the atmosphere inside the second cell 30 to the outside. The vent pipe 60 is configured to open due to structural interference between the components of the sensor unit 100 and the components of the measuring instrument 200 when the sensor unit 100 is attached to the measuring instrument 200. Specifically, when the sensor unit 100 is attached to the measuring instrument 200, the end of the vent pipe 60, which is a component of the sensor unit 100, is broken by a needle-shaped member 210, which is a component of the measuring instrument 200, thereby opening the vent pipe 60. With the opening of this vent pipe 60, the test liquid S stored in the first cell 20 can flow into the second cell 30 via the flow path 50 by capillary action. In other words, the supply of the test liquid S into the second cell 30 can be triggered by the attachment to the measuring instrument 200. As a result, it becomes possible to bring the test solution S and the sensor electrode 40 into contact within the second cell 30 and generate an electrochemical reaction. Furthermore, by attaching the sensor unit 100 to the measuring instrument 200, the measuring instrument 200 can perform a predetermined voltage sweep scan on the sensor electrode 40, thereby measuring specific components contained in the test liquid S. As described above, the sensor unit 100 of this embodiment suppresses contact between the test liquid S and the sensor electrode 40 from the time the test liquid S is collected until it is subjected to measurement, while simultaneously triggering contact between the test liquid S and the sensor electrode 40 when it is attached to the measuring instrument 200, thereby enabling measurement with high sensor sensitivity. Moreover, since the variation in measurement accuracy can be reduced, the reproducibility of the measurement results can be maintained at a high level.

[0040] (b) According to the measurement system 1 of this embodiment, for example, the measuring instrument 200 can be installed inside the wall 400a of the toilet 400, and the subject can perform the measurement using the sensor unit 100. In other words, the measurement can be performed easily, and high convenience can be achieved. Furthermore, multiple subjects can share one measuring instrument 200 by each attaching a sensor unit 100 to it. Therefore, the system cost can be reduced.

[0041] (c) In the sensor unit 100, it is preferable that the flow path 50 has a shape that allows capillary action to occur. This makes it possible to more reliably allow the test liquid S stored in the first cell 20 to flow into the second cell 30.

[0042] (d) In the sensor unit 100, it is preferable that the volume of the second cell 30 is smaller than the volume of the first cell 20. This allows the test fluid S and the sensor electrode 40 to come into contact more reliably within the second cell 30, even when the amount of test fluid S supplied from the second cell 30 to the first cell 20 is small.

[0043] (e) In the measurement system 1, it is preferable that the measuring instrument 200 is configured to start electrochemical measurement when the sensor unit 100 is attached to the measuring instrument 200. This allows the test solution S to be supplied to the second cell 30 and the test solution S to be brought into contact with the sensor electrode 40 to perform electrochemical measurement. As a result, fluctuations in sensor sensitivity can be avoided and the reproducibility of measurement results can be improved.

[0044] (f) In the measurement system 1, it is preferable that the measuring instrument 200 is configured to start electrochemical measurement after a predetermined time has elapsed since the sensor unit 100 was attached to the measuring instrument 200. This allows the flow of the test liquid S in the second cell 30 to be measured in a steady state. As a result, the reproducibility of the measurement results can be further improved.

[0045] <Other Embodiments> Although embodiments of the present invention have been described above, the present invention is not limited in any way to the embodiments described above, and can be modified in various ways without departing from the spirit of the invention.

[0046] In the above-described embodiment, a case was explained in which a subject collects a test fluid S into the sensor unit 100 and immediately attaches it to the measuring instrument 200, but the present invention is not limited to this. With the sensor unit 100, contact between the test fluid S and the sensor electrode 40 can be suppressed until it is attached to the measuring instrument 200, so the test fluid S may be collected, a predetermined time may have elapsed, and then attached to the measuring instrument 200 for measurement. For example, after collecting test fluids from multiple subjects, a certain amount of time may have elapsed before each sensor unit 100 is attached to the measuring instrument 200 for measurement.

[0047] In the above-described embodiment, the supply of the test liquid S from the first cell 20 to the second cell 30 via the flow path 50 was explained as an example in which the vent pipe 60 is opened due to structural interference between components when the sensor unit 100 is attached to the measuring instrument 200, but the present invention is not limited to this. Hereinafter, modifications of the trigger structure due to structural interference will be described.

[0048] In the above embodiment, the case in which the vent pipe 60 is broken and opened by the needle-shaped member 210 was described, but the opening of the vent pipe 60 is not limited to this. For example, the vent pipe 60 may be equipped with an openable and closable valve (not shown) at the end on the measuring instrument 200 side, and configured so that the valve opens due to structural interference when the sensor unit 100 is inserted into the insertion port of the measuring instrument 200. The opening of the valve allows the atmosphere inside the second cell 30 to escape to the outside. In this way, when the sensor unit 100 is attached to the measuring instrument 200, the opening of the valve triggers the flow of the test liquid S into the second cell 30. The valve is not particularly limited as long as it is configured to open and close physically or electrically when the sensor unit 100 is attached to the measuring instrument 200.

[0049] Alternatively, as shown in Figure 4(a), a notch region 62 may be formed in the sensor unit 100 in the region including one end of the vent pipe 60 (dashed line region in the figure). In this case, as shown in Figure 4(b), when the sensor unit 100 is inserted into the insertion port of the measuring instrument 200, the notch region 62 in the sensor unit 100 is removed due to structural interference. This removes the end of the vent pipe 60. As a result, the vent pipe 60 is opened, allowing the atmosphere inside the second cell 30 to escape to the outside. Consequently, the test liquid S can flow from the first cell 20 to the second cell 30 via the flow path 50. Thus, when the sensor unit 100 is attached to the measuring instrument 200, the removal of the notch region 62 triggers the flow of the test liquid S into the second cell 30.

[0050] Alternatively, for example, the supply of the test fluid S from the first cell 20 to the second cell 30 may be configured to begin by the formation of a flow path 50 through structural interference, instead of opening the vent pipe 60. Specifically, as shown in Figure 5(a), a blockage point 51 (dashed line area in the figure) is provided in a part of the flow path 50 connecting the first cell 20 and the second cell 30. The blockage point 51 can be provided, for example, by constructing the flow path 50 from a flexible member and bending or folding a part of it in the direction of flow. The test fluid S taken into the first cell 20 will not flow into the second cell 30 due to the blockage point 51 and will remain there. In this case, as shown in Figure 5(b), when the sensor unit 100 is attached to the measuring instrument 200, the flow path 50 is deformed into a straight line by structural interference between the measuring instrument 200 and the sensor unit 100, thereby opening the flow path 50. As a result, for example, the test fluid S flows from the first cell 20 to the second cell 30 via the flow path 50 by capillary action. In Figure 5(a), the second cell 30 is equipped with a hole (not shown) to release air from the atmosphere to the outside, and is configured so that when the test fluid flows into the second cell 30, the atmosphere inside the second cell 30 escapes to the outside.

[0051] Alternatively, instead of providing a blockage point 51 in the flow path 50, a plug (not shown) that physically blocks the flow path 50 may be provided. The flow path 50 may be opened by opening and closing or destroying this plug through structural interference. This plug can be made of resin or plastic. With such a plug, for example, when the sensor unit 100 is inserted into the measuring instrument 200, heat, vibration, or shock can be applied to the flow path 50, destroying the plug and opening the flow path 50. The plug may also be made of a magnetic material, in which case the plug can be opened and closed by magnetism as structural interference.

[0052] Alternatively, as shown in Figure 6(a), the first cell 20 may be configured to be compressible due to structural interference. The first cell 20 can be made of a flexible material (e.g., resin or plastic). The first cell 20 is configured to take in the test liquid S from the intake port, but to prevent the test liquid S from flowing out from the intake port when compressed. For example, a check valve can be provided at the intake port of the first cell 20. On the other hand, the second cell 30 may be provided with a hole (not shown) to release the air in the atmosphere to the outside. The flow path 50 should have a diameter such that the test liquid S is not pumped up by capillary action. In this case, the test liquid S is taken in by the first cell 20, but remains there without flowing into the second cell 30. Then, as shown in Figure 6(b), the compression of the first cell 20 causes the test liquid S to be pumped to the second cell 30 via the flow path 50. Here, the compression of the first cell 20 when the sensor unit 100 is attached to the measuring instrument 200 can be used as a trigger to supply the test fluid S to the second cell 30.

[0053] Alternatively, as shown in Figure 7(a), the second cell 30 may be configured to expand due to structural interference. The second cell 30 may be made of a flexible material (such as resin or plastic). Furthermore, the second cell 30 may be configured to be airtight inside. In this case, although the test fluid S is taken into the first cell 20, because the second cell 30 is airtight, it does not flow into the second cell 30 but remains in the first cell 20. Then, as shown in Figure 7(b), the second cell 30 expands due to structural interference, and the negative pressure generated inside the second cell 30 draws the test fluid S from the first cell 20 to the second cell 30 via the flow path 50. Here, the expansion of the second cell 30 due to structural interference can be used as a trigger to supply the test fluid S to the second cell 30.

[0054] In the above-described embodiment, structural interference caused by attaching the sensor unit 100 to the measuring instrument 200 was explained as an example of a trigger for the flow of the test fluid S from the first cell 20 to the second cell 30, but the present invention is not limited thereto. The trigger is not limited to the attachment of the sensor unit 100 to the measuring instrument 200, but may also be caused by structural interference with the components of the sensor unit 100 through external operations such as manual labor or jigs, thereby supplying the test fluid from the first cell 20 to the second cell 30. For example, the test fluid S may be allowed to flow into the second cell 30 by external operations such as rupturing the end of the vent pipe 60 or removing the notched area 62 from the sensor unit 100 that has stored the test fluid S, and then the sensor unit 100 may be attached to the measuring instrument 200. Alternatively, the trigger may be a non-contact structural interference, such as using a magnet, to supply the test fluid to the second cell 30. For example, the test fluid S may be allowed to flow into the second cell 30 by opening the valve or removing the stopper using a magnet or the like, and then the sensor unit 100 may be attached to the measuring instrument 200.

[0055] Furthermore, although the above-described embodiment described a case in which the sensor unit 100 is equipped with a flow path 50, the present invention is not limited to this. For example, as shown in Figure 8, the first cell 20 and the second cell 30 may be configured so that their respective spaces are separated by a partition wall 52. In this case, it is preferable to break the partition wall 52 when the sensor unit 100 is attached to the measuring instrument 200. The crack in the partition wall 52 can serve as a flow path to supply the test liquid S from the first cell 20 to the second cell 30.

[0056] In the embodiments described above, the case in which an electrochemical reaction occurring in contact with the test solution S is measured using a sensor electrode 40 was explained as an example, but the present invention is not limited to this. For example, a test sheet that changes color in reaction with a specific component contained in the test solution S may be used in combination with the sensor electrode 40. In this case, for example, as shown in Figure 9, the test sheet 70 may be enclosed in the second cell 30 together with the sensor electrode 40.

[0057] The test sheet 70 is configured such that its working surface changes color upon contact with the test solution S. The test sheet 70 allows for the measurement of components in a different manner than the sensor electrode 40. Therefore, by using the sensor electrode 40 and the test sheet 70 together, it becomes possible to measure components that are difficult to measure with the sensor electrode 40, for example, using the test sheet 70. In other words, it becomes possible to measure multiple components contained in the test solution S simultaneously. The test sheet 70 is not particularly limited as long as it exhibits color change upon contact with specific components; conventionally known sheets can be used.

[0058] When using the test sheet 70, the same problems as with the sensor electrode 40 may arise. If the test solution S is left in contact with the test sheet 70, certain components in the test solution S (e.g., proteins) may deposit on the surface, altering the degree of discoloration. Furthermore, the amount of this change can vary significantly depending on the contact time and environmental conditions. In this regard, by adopting the configuration shown in Figure 9, the supply of the test solution S to the test sheet 70 can be adjusted to the same timing as the supply to the sensor electrode 40. As a result, the reproducibility of the measurement results can be further improved.

[0059] Furthermore, if an inspection sheet 70 is provided, it is preferable that the measuring instrument 200 further includes an imaging means for photographing the working surface of the inspection sheet 70, and that the imaging of the inspection sheet 70 is triggered by the attachment of the sensor unit 100 to the measuring instrument 200. This makes it possible to measure the discoloration of the inspection sheet 70 along with the measurement of the electrochemical reaction at the sensor electrode 40. Alternatively, it is preferable that the measuring instrument 200 is configured to start imaging the inspection sheet 70 after a predetermined time has elapsed following the attachment of the sensor unit 100 to the measuring instrument 200. This makes it possible to photograph the discoloration of the inspection sheet 70 after the inflow of the test liquid S into the second cell 30 is complete and the inside of the second cell 30 has reached a steady state. As a result, the reproducibility of the measurement results can be further improved. Note that the measuring means and the imaging means for performing electrochemical measurement may be configured as the same device or as separate devices.

[0060] Furthermore, in Figure 9, an odor sensor may be used instead of the inspection sheet 70, or the sensor electrode 40, inspection sheet 70, and odor sensor may be used in combination. Since odors also change over time, the same problems as with the sensor electrode 40 may arise, but these problems can be solved by encapsulating them in the second cell 30.

[0061] Figure 9 shows the case where the sensor electrode 40 and the inspection sheet 70 are used together, but it is also possible to use only the inspection sheet 70. As mentioned above, even with the inspection sheet 70, variations in measurement accuracy may occur due to the passage of time due to contact with the test liquid S. In this regard, by adopting the configuration of the embodiment described above, it is possible to reduce variations in measurement accuracy with the inspection sheet 70 and maintain high reproducibility of the measurement results. It is preferable to use a measuring instrument 200 that is equipped with a means for photographing the working surface of the inspection sheet 70.

[0062] Alternatively, as shown in Figure 10, for example, a third cell 80 for temporarily storing the test solution S may be provided on the flow path 50 between the first cell 20 and the second cell 30. The third cell 80 can function as a flow rate adjustment unit to adjust the time it takes for the test solution S to flow from the first cell 20 to the second cell 30, or as a reaction unit that contains a predetermined reagent to react with the test solution S. When functioning as a reaction unit, the third cell 80 may contain, for example, a reagent 81 that reacts with components contained in the test solution S. Depending on the components contained in the test solution S, it may be difficult to directly measure the electrochemical reaction. In this regard, it is possible to supply the test solution S from the first cell 20 to the second cell 30 via the third cell 80 containing the reagent, etc. This allows the test solution S to be reacted and then subjected to electrochemical measurement.

[0063] In the embodiments described above, the case where there is one second cell 30 was explained, but the present invention is not limited thereto. For example, as shown in Figure 11, a single first cell 20 may be configured so that each of the multiple second cells 30 is connected to it via a flow path 50. In this case, a vent pipe 60 is connected to each second cell 30, and the vent pipe 60 is configured to open due to structural interference. With such a configuration, by changing the measurement conditions of the sensor electrodes 40 contained in the multiple second cells 30, multiple components contained in the test liquid S can be measured in parallel. Figure 11 shows a case where each of the three second cells 30 has a sensor electrode 40, corresponding to the three connection terminals 42, and one of the second cells 30 contains an inspection sheet 70. Furthermore, the arrangement of the multiple second cells 30 is not particularly limited; for example, the first cell 20 can be placed in the center, and the multiple second cells 30 can be arranged radially around it. Also, Figure 11 shows a case where the number of second cells 30 is four, but the number is not particularly limited. Furthermore, while Figure 11 shows the case where the test fluid S flows in triggered by the opening of the vent pipe 60, the compression of the first cell 20 or the expansion of the second cell 30, as described above, may also be used as triggers.

[0064] Furthermore, when multiple second cells 30 are provided, the lengths of the flow channels 50 connected to each may be the same or different. If the lengths of the flow channels 50 are the same, the timing of the flow of the test fluid S into each second cell 30 can be simultaneous. On the other hand, if the lengths of the flow channels 50 are configured to be different, the time it takes for the test fluid S to flow into each second cell 30 can be intentionally staggered.

[0065] Furthermore, when multiple second cells 30 are provided, at least one of the multiple flow paths 50 may have a third cell between the first cell 20 and the second cell 30. This allows for adjusting the time it takes for the test solution S to flow into the second cell 30 to be relatively long in the system that passes through the third cell and relatively short in the system that does not. Alternatively, in the system that passes through the third cell, the test solution S is reacted with a reagent contained in the third cell before flowing into the second cell 30, while in the system that does not pass through the third cell, the test solution S can flow directly into the second cell 30.

[0066] Furthermore, although Figure 9 illustrates the case where the sensor electrode 40 and the inspection sheet 70 are contained within a single second cell 30, if multiple second cells 30 are provided, the sensor electrode 40 and the inspection sheet 70 may be contained within separate second cells 30. If the sensor electrode 40 and the inspection sheet 70 are in the same space, they may interfere with each other's measurements, but this interference can be reduced by separating them into different second cells 30.

[0067] Furthermore, although the above-described embodiment described a case in which the test fluid S is flowed through the sensor unit 100 before it is attached to the measuring instrument 200, the present invention is not limited to this. The test fluid S may also be flowed through the first cell 20 while the sensor unit 100 is attached to the measuring instrument 200. In this case, the test fluid S is stored in the first cell 20 and simultaneously flows into the second cell 30 via the flow path 50. In other words, the sensor unit 100 can automatically cause the test fluid S to flow into the second cell 30 while it is attached to the measuring instrument 200.

[0068] Furthermore, although the above-described embodiment described a case in which the first cell 20 is equipped with an intake port 21 and configured to take in the test liquid S from the intake port 21 and store the test liquid S in its internal space, the present invention is not limited thereto. For example, the first cell 20 may be configured with a tube connected to it that can take in the test liquid S from the outside, for example by capillary action, instead of the intake port 21. Alternatively, the first cell 20 may be formed from a hygroscopic material and configured to retain and store the flowing test liquid S.

[0069] Furthermore, although the above-described embodiment described a case in which the measurement system 1 comprises a sensor unit 100, a measuring instrument 200, and a judgment support device 300, the judgment support device 300 may be provided only if necessary and can be omitted.

[0070] Furthermore, a preferred embodiment is a measurement system for measuring a subject's urine, comprising: a portable sensor unit that is detachable from a measuring instrument for performing electrochemical measurements and configured to collect the subject's urine when it is flushed down the toilet; a measuring instrument installed on the inner wall of a toilet, connectable to the sensor unit and configured to perform electrochemical measurements; and a judgment support device configured to output the measurement results from the measuring instrument.

[0071] With this type of measurement system, the measuring device is installed inside the toilet wall, while the sensor unit is portable by the subject. This allows the subject to collect urine in the toilet and easily provide it to the measuring device. Furthermore, since multiple subjects can each measure their urine with a single measuring device, system costs can be reduced. Additionally, with the judgment support device, for example, after registering the subject's individual ID, the measurement results can be associated with the ID, allowing the system to output the measurement results for a specific subject even when multiple subjects use it.

[0072] <Preferred aspects of this disclosure> Preferred embodiments of this disclosure are described below.

[0073] (Note 1) A sensor unit configured to be detachable from a measuring instrument for performing electrochemical measurements, A first cell that temporarily stores the test fluid supplied from an external source, It comprises a second cell containing a sensor electrode, A sensor unit configured such that the supply of the test fluid from the first cell to the second cell is triggered by the attachment of the sensor unit to the measuring instrument.

[0074] (Note 2) When the sensor unit is detached from the measuring instrument and the test fluid is supplied to the sensor unit, the test fluid is configured to remain in the first cell without flowing into the second cell. The sensor unit described in Appendix 1.

[0075] (Note 3) The structural interference between the components of the measuring instrument and the components of the sensor unit when the sensor unit is attached to the measuring instrument is configured to function as the trigger. The sensor unit described in Appendix 1 or Appendix 2.

[0076] (Note 4) The second cell is provided with a vent pipe for releasing the atmosphere inside the second cell to the outside, The sensor unit is configured such that when it is attached to the measuring instrument, the vent tube is opened due to structural interference of the components, and the flow of the test fluid into the second cell begins. The sensor unit described in Appendix 3.

[0077] (Note 5) When the sensor unit is attached to the measuring instrument, a flow path is formed that connects the inside of the first cell and the inside of the second cell due to the structural interference of the components, and the flow of the test fluid into the second cell is initiated through the flow path. The sensor unit described in Appendix 3.

[0078] (Note 6) The first cell and the second cell are separated by a partition wall. When the sensor unit is attached to the measuring instrument, the partition wall breaks due to structural interference of the components, and the crack formed in the partition wall becomes the flow path. The sensor unit described in Appendix 5.

[0079] (Note 7) The sensor unit is configured such that when it is attached to the measuring instrument, the structural interference of the components compresses the first cell, and the pumping of the test fluid into the second cell begins. The sensor unit described in Appendix 3.

[0080] (Note 8) The sensor unit is mounted on the measuring instrument, and the structural interference of the components causes the second cell to expand, and the negative pressure generated within the second cell initiates the suction of the test fluid into the second cell. The sensor unit described in Appendix 3.

[0081] (Note 9) It is provided with a flow path that connects the first cell and the second cell, The flow path has a shape that causes capillary action to occur when the test fluid is drawn from the first cell into the second cell. The sensor unit described in any one of the appendices 4 through 8.

[0082] (Note 10) When the test fluid is supplied to the sensor unit while it is attached to the measuring instrument, The system is configured such that the test fluid flows from the first cell into the second cell. The sensor unit described in any one of the appendices 1 to 9.

[0083] (Note 11) The volume of the second cell is smaller than the volume of the first cell. The sensor unit described in any one of the appendices 1 to 10.

[0084] (Note 12) A flow path connecting the first cell and the second cell, The flow path includes a third cell for temporarily storing the test fluid, The flow of the test fluid into the second cell is configured to occur via the flow path through the third cell. The sensor unit described in appendices 4-7.

[0085] (Note 13) The third cell contains a reaction reagent that can react with a specific component in the test solution. The sensor unit described in Appendix 14.

[0086] (Note 14) For one first cell, there are multiple second cells, Each of the aforementioned plurality of second cells is provided with a vent pipe for releasing the atmosphere inside each second cell to the outside, The sensor unit is configured such that when it is attached to the measuring instrument, the vent tube is opened due to structural interference of the components, and the flow of the test fluid into the plurality of second cells begins. The sensor unit described in Appendix 3.

[0087] (Note 15) The device includes a plurality of channels that connect the first cell with each of the plurality of second cells, The aforementioned multiple flow channels are configured such that their lengths are the same or different. The sensor unit described in Appendix 14.

[0088] (Note 16) At least one of the plurality of channels is provided with a third cell for temporarily storing the test fluid, The flow of the test fluid from the first cell into the second cell is configured to occur via the flow path through the third cell. The sensor unit described in Appendix 15.

[0089] (Note 17) A test sheet is placed inside the second cell, configured such that its surface changes color upon contact with the test solution. The sensor unit described in any one of the appendices 1 to 16.

[0090] (Note 18) A measuring instrument configured to be connectable to any one of the sensor units described in Appendix 1 to Appendix 17, and equipped with measuring means for performing electrochemical measurements, A measuring instrument configured to initiate the electrochemical measurement by being triggered by the attachment of the sensor unit to the measuring instrument.

[0091] (Note 19) A measuring instrument configured to be connectable to any one of the sensor units described in Appendix 1 to Appendix 17, and equipped with measuring means for performing electrochemical measurements, A measuring instrument configured to initiate the electrochemical measurement after a predetermined time has elapsed since the sensor unit was attached to the measuring instrument.

[0092] (Note 20) A measuring instrument configured to be connectable to the sensor unit described in Appendix 17, and equipped with a means for photographing the working surface of the inspection sheet, A measuring instrument configured to take a photograph of the inspection sheet as a trigger when the sensor unit is attached to the measuring instrument.

[0093] (Note 21) A measuring instrument configured to be connectable to the sensor unit described in Appendix 17, and equipped with a means for photographing the working surface of the inspection sheet, A measuring instrument configured to take a photograph of the inspection sheet after a predetermined time has elapsed since the sensor unit was attached to the measuring instrument.

[0094] (Note 22) The aforementioned test fluid is urine. The aforementioned measuring device is installed inside the toilet. The measuring instrument described in any one of the appendices 18 to 21.

[0095] (Note 23) A sensor unit configured to be detachable from a measuring instrument, A first cell that temporarily stores the test fluid supplied from an external source, The system comprises a second cell containing a test sheet configured to change color on its surface upon contact with the aforementioned test solution, A sensor unit configured such that the supply of the test fluid from the first cell to the second cell is triggered by the attachment of the sensor unit to the measuring instrument.

[0096] (Note 24) A measurement system for measuring the urine of a subject, A sensor unit that is portable, detachable from a measuring instrument for performing electrochemical measurements, and configured to collect urine when the subject's urine is poured over it, The system includes a measuring instrument that can be connected to the aforementioned sensor unit and is configured to perform electrochemical measurements, The measuring device is installed on the inner wall of the toilet. Urine measurement system.

[0097] (Note 25) The aforementioned sensor unit is A first cell for temporarily storing the urine of the subject, It comprises a second cell containing a sensor electrode, The supply of the test fluid from the first cell to the second cell is configured to be triggered by the attachment of the sensor unit to the measuring instrument. The measuring instrument is configured to initiate the electrochemical measurement when the sensor unit is attached to the measuring instrument. The urine measurement system described in Appendix 24. [Explanation of Symbols]

[0098] 1. Measurement System 100 Sensor Units 200 measuring instruments 300 Judgment support device 400 toilet bowls 10 Base material 20 Cell 1 21 Intake 30 Cell 2 40 Sensor electrodes 41 Wiring 42 Connection terminals 50 flow channels 51 Blockages 60 Bent pipes 61 valves 62 Notch area 70 Inspection Sheets 80 Cell 3 81 Reagents S Test liquid

Claims

1. A sensor unit configured to be detachable from a measuring instrument for performing electrochemical measurements, Substrate and A first cell is placed on the substrate and temporarily stores the test fluid supplied from the outside, The substrate is disposed on the aforementioned substrate and comprises a second cell containing a sensor electrode, A sensor unit configured such that the supply of the test fluid from the first cell to the second cell is triggered by the attachment of the sensor unit to the measuring instrument.

2. When the sensor unit is detached from the measuring instrument and the test fluid is supplied to the sensor unit, the test fluid is configured to remain in the first cell without flowing into the second cell. The sensor unit according to claim 1.

3. The structural interference between the components of the measuring instrument and the components of the sensor unit when the sensor unit is attached to the measuring instrument is configured to function as the trigger. The sensor unit according to claim 1.

4. The second cell is provided with a vent pipe for releasing the atmosphere inside the second cell to the outside, The sensor unit is configured such that when it is attached to the measuring instrument, the vent tube is opened due to structural interference of the components, and the flow of the test fluid into the second cell begins. The sensor unit according to claim 3.

5. The vent pipe is configured to partially break and open due to structural interference with the measuring instrument when the sensor unit is attached to the measuring instrument. The sensor unit according to claim 4.

6. It has a notched region that is configured to allow cutting out a portion of the area including a part of the aforementioned vent pipe, The vent pipe is configured such that, when the sensor unit is attached to the measuring instrument, the notched area is removed due to structural interference with the measuring instrument, and a portion of it is left open. The sensor unit according to claim 4.

7. When the sensor unit is attached to the measuring instrument, a flow path is formed that connects the inside of the first cell and the inside of the second cell due to the structural interference of the components, and the flow of the test liquid into the second cell is initiated through the flow path. The sensor unit according to claim 3.

8. The sensor unit is configured such that when it is attached to the measuring instrument, the structural interference of the components compresses the first cell, and the pumping of the test fluid into the second cell begins. The sensor unit according to claim 3.

9. The sensor unit is configured such that when it is attached to the measuring instrument, the second cell expands due to structural interference of the components, and the negative pressure generated inside the second cell initiates the suction of the test fluid into the second cell. The sensor unit according to claim 3.

10. It is provided with a flow path that connects the first cell and the second cell, The flow path has a shape that causes capillary action to occur when the test fluid is drawn from the first cell into the second cell. The sensor unit according to claim 4.

11. A flow path connecting the first cell and the second cell, The system comprises a third cell provided on the substrate and for temporarily storing the test liquid in the flow path, The flow of the test fluid from the first cell into the second cell is configured to occur via the third cell. The sensor unit according to claim 3.

12. For one first cell, there are multiple second cells, Each of the aforementioned plurality of second cells is provided with a vent pipe for releasing the atmosphere inside each second cell to the outside, The sensor unit is configured such that when it is attached to the measuring instrument, the vent tube is opened due to structural interference of the components, and the flow of the test fluid into the plurality of second cells begins. The sensor unit according to claim 3.

13. The device includes a plurality of channels that connect the first cell with each of the plurality of second cells, The aforementioned multiple flow channels are configured such that their lengths are the same or different. The sensor unit according to claim 12.

14. When the test fluid is supplied to the sensor unit while it is attached to the measuring instrument, The system is configured such that the test fluid flows from the first cell into the second cell. The sensor unit according to claim 1.

15. A test sheet is placed inside the second cell, configured such that its surface changes color upon contact with the test solution. The sensor unit according to claim 1.

16. A measuring instrument configured to be connectable to the sensor unit described in claim 1, and equipped with measuring means for performing electrochemical measurements, A measuring instrument configured to initiate the electrochemical measurement by being triggered by the attachment of the sensor unit to the measuring instrument.

17. A measuring instrument configured to be connectable to the sensor unit described in claim 1, and equipped with measuring means for performing electrochemical measurements, A measuring instrument configured to initiate the electrochemical measurement after a predetermined time has elapsed since the sensor unit was attached to the measuring instrument.

18. A measuring instrument configured to be connectable to the sensor unit described in claim 15, and comprising a photographing means for photographing the working surface of the inspection sheet, A measuring instrument configured to take a photograph of the inspection sheet as a trigger when the sensor unit is attached to the measuring instrument.

19. A measuring instrument configured to be connectable to the sensor unit described in claim 15, and comprising a photographing means for photographing the working surface of the inspection sheet, A measuring instrument configured to take a photograph of the inspection sheet after a predetermined time has elapsed since the sensor unit was attached to the measuring instrument.

20. The aforementioned test fluid is urine. The aforementioned measuring device is installed inside the toilet. A measuring instrument according to any one of claims 16 to 19.

Images