Affinity-matured MICA antibodies and their applications

Abstract

To provide affinity matured MICA antibodies and applications thereof, more specifically, antibodies or antigen binding fragments thereof, nucleic acid molecules, expression vectors, methods for preparing the antibodies or antigen binding fragments thereof, recombinant cells, compositions and uses thereof, pharmaceuticals and uses thereof.SOLUTION: The invention presents an antibody or antigen binding fragment thereof and uses thereof. The antibody or antigen binding fragment thereof comprises heavy chain variable region CDR1, CDR2 and CDR3 each having a specific amino acid sequence or an amino acid sequence having at least 80% identity to the specific sequence, and light chain variable region CDR1, CDR2 and CDR3 each having a specific amino acid sequence or an amino acid sequence having at least 80% identity to the specific sequence. The antibody or antigen binding fragment thereof binds to human and monkey MICA protein with high affinity and promotes the tumor killing by PBMC (human peripheral blood mononuclear cell).SELECTED DRAWING: Figure 1

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