Functional antibody fragments complementing each other for a two-component system against unwanted retargeting cell death.

A two-component T cell binding agent system with a cleavable inactive binding partner and cleavage site provides targeted and specific activation of T cells on undesirable cells, addressing the lack of specificity and off-target effects in existing immunotherapies.

JP7864778B2Active Publication Date: 2026-05-25REVITOPE LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
REVITOPE LTD
Filing Date
2024-07-18
Publication Date
2026-05-25

AI Technical Summary

Technical Problem

Existing immunotherapeutic strategies for targeting unwanted cells, such as cancer cells, lack sufficient specificity and can cause undesirable side effects on other cell types, necessitating a more targeted and specific therapeutic approach.

Method used

A two-component system comprising a targeted T cell binding agent with a first T cell binding domain that becomes active upon binding to a second T cell binding domain, an inactive binding partner that prevents initial binding, and a cleavage site for separation, allowing localized and specific activation of T cells on undesirable cells.

Benefits of technology

Enables highly specific activation of T cells on undesirable cells, reducing off-target effects and enhancing therapeutic efficacy.

✦ Generated by Eureka AI based on patent content.

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Patent Text Reader

Abstract

To provide a targeted T-cell binding agent for treating a condition characterized by the presence of unwanted cells.SOLUTION: A two-component system for treating a condition characterized by the presence of unwanted cells comprises: a. a first component comprising a targeted T-cell binding agent; and b. a second component comprising a second T-cell binding domain capable of having T-cell binding activity when binding to the first T-cell binding domain, where the first and second T-cell binding domains are capable of binding when neither is bound to an inert binding partner.SELECTED DRAWING: Figure 1
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