Methods for determining genetic predisposition to hair loss

Abstract

To provide means for properly and easily determining the genetic predisposition to thin hair in the Japanese females.SOLUTION: A method for determining the genetic predisposition to thin hair in the Japanese females includes the steps for: detecting, in a DNA-containing sample from a subject, single nucleotide polymorphisms (SNPs) identified with rs2419385, rs76571283, or alleles of SNPs in linkage disequilibrium with these SNPs; and, if at least one base of the detected alleles is a risk allele, determining the subject has a genetic predisposition to thin hair.SELECTED DRAWING: None

Claims

[Claim 1] A method for determining the genetic predisposition to hair loss in Japanese women, comprising the steps of detecting one or more single nucleotide polymorphism (SNP) alleles from (a1) to (a4) below in a DNA-containing sample taken from a subject, and determining that the subject is prone to hair loss if at least one of the bases of the detected allele is a risk allele. (a1) SNP at the 101st base of the nucleotide sequence shown in Sequence ID No. 1 (SNP: SNP identified by ID rs2419385, risk allele is G) (a2) SNPs at the 101st base of the nucleotide sequence shown in Sequence ID No. 1 (SNP: SNP identified by ID rs2419385, risk allele is G) that have a linkage disequilibrium coefficient r2 ≥ 0.8 (a3) SNP at the 101st base of the nucleotide sequence shown in Sequence ID No. 6 (SNP: SNP identified by ID rs76571283, risk allele is G) (a4) SNPs at the 101st base of the nucleotide sequence shown in Sequence ID No. 6 (SNP: SNP identified by ID rs76571283, risk allele is G) that have a linkage disequilibrium coefficient r2 ≥ 0.8 [Claim 2] A method for providing cosmetics and / or food and beverages (excluding medical procedures) to a subject, wherein, based on the results determined by the method of claim 1, the subject is provided with cosmetics and / or food and beverages according to the degree of the subject's genetic predisposition to hair loss. [Claim 3] A method of cosmetic counseling (excluding medical procedures) that corresponds to the degree of a subject's genetic predisposition to hair loss, based on the results determined by the method described in claim 1. [Claim 4] A kit for determining the genetic predisposition to hair loss in Japanese women, comprising: a probe having a sequence of 10 or more bases containing an SNP at the 101st base of the base sequence shown in Sequence ID No. 1 (SNP: ID rs2419385), an SNP at the 101st base of the base sequence shown in Sequence ID No. 6 (SNP: ID rs76571283), or an SNP with a linkage disequilibrium coefficient r2 ≥ 0.8, or a probe having a complementary sequence thereof; and / or a primer capable of amplifying a region containing an SNP at the 101st base of the base sequence shown in Sequence ID No. 1 (SNP: ID rs2419385), an SNP at the 101st base of the base sequence shown in Sequence ID No. 6 (SNP: ID rs76571283), or an SNP with a linkage disequilibrium coefficient r2 ≥ 0.8.

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