Antigen-nonspecific IgA secretion enhancer, and composition for enhancing antigen-nonspecific IgA secretion

γ-Polyglutamic acid enhances antigen-nonspecific IgA secretion to counteract age-related declines, maintaining immune function by increasing TI-SIgA levels.

JP7875592B2Active Publication Date: 2026-06-18NAT AGRI & FOOD RES ORG
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
NAT AGRI & FOOD RES ORG
Filing Date
2022-08-18
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

The secretion of antigen-nonspecific IgA (TI-SIgA), which is crucial for maintaining gut microbiota and intestinal immunity, decreases with age, leading to a decline in immune function.

⚗Method used

An antigen-nonspecific IgA secretion enhancer containing γ-polyglutamic acid (γ-PGA) or its salt is used to enhance TI-SIgA secretion, particularly through oral or parenteral administration, formulated into pharmaceuticals, foods, or feeds.

🎯Benefits of technology

γ-PGA effectively suppresses the age-related decline in TI-SIgA secretion, thereby maintaining immune function by enhancing antigen-nonspecific IgA secretion.

✦ Generated by Eureka AI based on patent content.

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Abstract

To provide an antigen-non-specific IgA secretion enhancer, and an antigen-non-specific IgA secretion enhancing composition that includes the antigen-non-specific IgA secretion enhancer.SOLUTION: An antigen-non-specific IgA secretion enhancer includes polyglutamic acid or a salt thereof as an active ingredient. There is also provided an antigen-non-specific IgA secretion enhancing composition that includes the antigen-non-specific IgA secretion enhancer, or a composition for inhibiting a decline in immune function associated with aging.SELECTED DRAWING: None
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