Mouse-derived colon epithelial cell line

A mouse-derived colon epithelial cell line from TCRα/p53 gene double knockout mice addresses the limitations of existing cancerous cell lines by mimicking normal cell properties, facilitating colorectal cancer research and agent screening.

JP7877034B2Active Publication Date: 2026-06-22YAKULT HONSHA KK
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Patent Information

Application Number
JP2022053999
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Filing Date
2022-03-29
Publication Date
2026-06-22
Estimated Expiration
2042-03-29

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Abstract

To provide a colonic epithelial cell strain similar to regular cells and a method for using the same.SOLUTION: The present invention provides a mouse-derived colonic epithelial cell strain similar to regular cells, where one or more properties selected from the following (a)-(j) are superior to those of the mouse colon cancer strain CMT-93: (a) a level of affinity with UEA-1 (gorse lectin), (b) an expression level of Asialo GM1, (c) an expression level of MUC2, (d) an mRNA expression level of GA1 synthase, (e) an mRNA expression level of Fucosyltransferase 2 (FUT2), (f) an mRNA expression level of NADPH oxidase (NOX-1), (g) an mRNA expression level of TLR5, (h) an mRNA expression level of LL37, (i) an mRNA expression level of CD130, and (j) a value of transepithelial electrical resistance (TEER value).SELECTED DRAWING: None
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Citation Information

Patent Citations

  • Immortal cell strain of human colon epithelium

    JP1998028580A

  • Human large intestinal cancer cell strain colm-5

    JP2003250535A

  • Intestinal epithelial-like cells and production method thereof

    JP2021122208A