Transfer sheet

Abstract

To provide a thin film that can prevent an antibacterial action from being lost in a short time, and a transfer sheet.SOLUTION: A thin film 10 has a first face 11F that has a thickness of 10 nm or more and 5000 nm or less and can be stuck to an adherend and a second face 11R opposite the first face 11F. The thin film 10 has an antibacterial region containing an antibacterial component, and a buffer region having the concentration of the antibacterial component being lower than that of the antibacterial region. The first face 11F is included in the buffer region. The antibacterial region may contain an aroma component. An antibacterial layer 20 is an antibacterial region. A contact layer 21 is the buffer region.SELECTED DRAWING: Figure 2

Description

Technical Field

[0001] The present invention , turn relates to a writing sheet.

Background Art

[0002] A thin film having a thickness of several μm or less adheres to an adherent body such as the skin of a living body without using an adhesive or a tackifier because it has high followability to the surface shape of the adherent body. Conventionally, various uses of such thin films have been proposed. For example, Patent Document 1 describes using a thin film for cosmetic applications such as skin care and makeup. Further, Non-Patent Document 1 describes using a thin film for medical applications such as wound healing.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Non-Patent Documents

[0004]

Non-Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] On the other hand, in order to widely spread thin films as cosmetic products, medical products, and further as daily necessities, it is required to add new functions to thin films. As part of this, adding an antibacterial function for the purpose of deodorization or the like to thin films has been studied.

[0006] Currently, most commercially available deodorizing products with antibacterial properties contain antibacterial components in the form of creams or liquids sprayed from a nozzle. These creams and liquids containing antibacterial components are applied directly to the target surface. As a result, the antibacterial effect is strong immediately after the cream or liquid comes into contact with the target surface, and then disappears quickly. Therefore, there is a need for a thin film that not only has antibacterial properties but also can suppress the loss of its antibacterial effect shortly after initial use.

[0007] This invention can suppress the rapid disappearance of antibacterial activity. ru ten The purpose is to provide photo sheets. [Means for solving the problem]

[0008] A thin film that solves the above problems has a thickness of 10 nm to 5000 nm and comprises a first surface that is attached to a substrate and a second surface opposite to the first surface, and has an antibacterial region containing an antibacterial component and a buffer region in which the concentration of the antibacterial component is lower than that of the antibacterial region, and the first surface is included in the buffer region.

[0009] According to the above configuration, when the thin film is attached to the substrate, a buffer zone is located between the antibacterial region, which contains a relatively large amount of antibacterial components, and the substrate. Therefore, the antibacterial components contained in the antibacterial region are prevented from coming into contact with the substrate all at once, thus preventing the antibacterial effect from disappearing quickly immediately after the thin film is attached.

[0010] In the above configuration, the antibacterial region may contain aromatic components. According to the above configuration, the thin film emits a fragrance, which provides a masking effect against unpleasant odors, thereby enhancing the deodorizing effect.

[0011] In the above configuration, the thin film may include an antibacterial layer which is the antibacterial region and a contact layer which is the buffering region. According to the above configuration, since the antibacterial region and the buffering region are separate layers, it is easy to form a thin film having both an antibacterial region and a buffering region.

[0012] In the above configuration, the contact layer may contain a water-soluble polymer. According to the above configuration, the contact layer dissolves due to moisture near the surface of the adherend, making it easier for the antibacterial components in the antibacterial layer to reach the adherend. Therefore, the presence of moisture near the surface of the adherend can be used to promote the action of the antibacterial components on the adherend.

[0013] In the above configuration, the thin film includes a cover layer that covers the antibacterial layer on the side opposite to the contact layer, and the second surface may be included in the cover layer. According to the above configuration, when the thin film is attached to the substrate, the antibacterial layer is covered by the cover layer. Therefore, the antibacterial and aromatic components contained in the antibacterial layer are prevented from escaping to the opposite side of the substrate, thereby increasing the duration of the effects of these components.

[0014] In the above configuration, the cover layer may contain a fragrance component. According to the above configuration, when the thin film is attached to the substrate, a fragrance is emitted from the layer exposed to the outside air, thereby enhancing the masking effect of unpleasant odors. Consequently, the deodorizing effect is enhanced.

[0015] In the above configuration, the antibacterial layer may contain a compound that is both an antibacterial component and a fragrance component. With the above configuration, compared to cases where the antibacterial component and the fragrance component are separate compounds, the effects of each component can be obtained with an antibacterial layer of simple composition.

[0016] In the above configuration, the antibacterial layer may have a thickness of 20 nm or more and less than 5000 nm. According to the above configuration, the adhesion between the thin film and the substrate is enhanced, and the strength of the antibacterial layer is obtained well. In addition, it is easy to incorporate a sufficient amount of antibacterial components into the antibacterial layer.

[0017] In the above configuration, the contact layer may have a thickness of 10 nm or more and 1000 nm or less. According to the above configuration, the followability of the first surface with respect to the adherent is enhanced, and the arrival of the antibacterial component contained in the antibacterial layer to the adherent proceeds favorably. Further, the strength of the contact layer is favorably obtained.

[0018] In the above configuration, the thickness of the contact layer may be smaller than the thickness of the antibacterial layer. According to the above configuration, with respect to the amount of the antibacterial component contained in the antibacterial layer, the contact layer having a function of moderating the arrival of the antibacterial component to the adherent does not become too thick, so that the contact layer has a thickness suitable for the function. Therefore, the antibacterial component contained in the antibacterial layer acts on the adherent at an appropriate rate and for a duration. Further, since the followability of the first surface with respect to the surface shape of the adherent is relatively enhanced, the adhesion between the thin film 10 and the adherent is enhanced.

[0019] In the above configuration, the ratio of the mass of the antibacterial component contained in the thin film to the entire thin film may be 50 ppm or more and 30% or less. According to the above configuration, good antibacterial action and its persistence are obtained.

[0020] In the above configuration, the blocking rate, which is the ratio of suppressing the evaporation amount of water having the same temperature as the human body temperature at the location where the thin film is disposed to the evaporation amount when the thin film is not disposed, may be 5% or more and 70% or less.

[0021] According to the above configuration, it is possible to moisturize the adherent with the thin film, and when the adherent is the skin, a good water evaporation amount is obtained at the location where the thin film is attached. As a result, the homeostasis of the skin is easily maintained normally.

[0022] In the above configuration, the thin film may contain a biocompatible material. According to the above configuration, the suitability of the thin film for attachment to a living body is enhanced.

[0023] A transfer sheet that solves the above problems comprises the thin film and a support substrate that supports the thin film. According to the above configuration, the thin film is supported by a support substrate, which suppresses deformation of the thin film and makes it easier to handle. [Effects of the Invention]

[0024] According to the present invention, the rapid disappearance of antibacterial activity can be suppressed. [Brief explanation of the drawing]

[0025] [Figure 1] A diagram showing an example of the cross-sectional structure of a thin film, representing one embodiment of a thin film. [Figure 2] A figure showing another example of the cross-sectional structure of a thin film according to one embodiment. [Figure 3] A diagram showing the cross-sectional structure of one embodiment of the transfer sheet. [Figure 4] A diagram showing a perspective view of a container housing a transfer sheet according to one embodiment. [Modes for carrying out the invention]

[0026] An embodiment of the thin film and transfer sheet will be described with reference to the drawings. The object to which the thin film of this embodiment is attached is not particularly limited, as long as it is an object to which it is desirable to suppress the growth of bacteria near its surface. Examples of such objects include living organisms such as skin and organs, objects that were once living organisms such as corpses, taxidermied animals and leather products, works of art, and home appliance filters.

[0027] In particular, the thin film of this embodiment is preferably used when the adherend is the skin of a living organism. When bacteria proliferate on the skin due to sweat, etc., unpleasant odors are likely to occur, so suppressing the proliferation of bacteria on the skin is an important issue. On the other hand, if the antibacterial effect is excessive on the skin, skin irritation such as redness and itching is likely to occur. When the adherend is the skin, protecting the skin from the antibacterial effect is also an objective of the thin film of this embodiment.

[0028] [Composition of thin film and transfer sheet] As shown in Figure 1, the thin film 10 has a first surface 11F that is attached to the substrate and a second surface 11R that is opposite to the first surface 11F. The second surface 11R is the outermost surface located on the opposite side of the substrate when the thin film 10 is attached to the substrate.

[0029] The thickness of the thin film 10 is between 10 nm and 5000 nm. If the thickness of the thin film 10 is 5000 nm or less, good conformability of the thin film 10 to the surface shape of the adherend is obtained, thereby improving the adhesion between the thin film 10 and the adherend. Therefore, the thin film 10 adheres to the adherend without the need for adhesive or glue. Also, if the adherend is skin, if the thickness of the thin film 10 is 5000 nm or less, the user of the thin film 10 is less likely to feel discomfort such as tightness in the skin where the thin film 10 is attached. Therefore, the suitability of the thin film 10 for long-term attachment is improved. Furthermore, if the thickness of the thin film 10 is 10 nm or more, good strength of the thin film 10 can be obtained.

[0030] The thickness of the thin film 10 is an average thickness, which is the average value of the film thickness of the thin film 10 measured at five or more measurement points by cross-sectional observation using a scanning electron microscope. If the thin film 10 contains solid matter such as powder that is insoluble in the coating liquid used to form the thin film 10, the measurement points are set in areas where no solid matter is present in the cross-section.

[0031] The thin film 10 comprises an antibacterial layer 20 containing an antibacterial component as a functional component, and a contact layer 21 that comes into contact with the adherend. The antibacterial layer 20 is an example of an antibacterial region, and the contact layer 21 is an example of a buffer region. When the thin film 10 is a laminate of the antibacterial layer 20 and the contact layer 21, the first surface 11F is the surface of the contact layer 21, and the second surface 11R is the surface of the antibacterial layer 20. In addition to the antibacterial component, the antibacterial layer 20 may also contain an aromatic component as a functional component.

[0032] When the thin film 10 is attached to an object, a contact layer 21 is located between the antibacterial layer 20 and the object. The antibacterial components of the antibacterial layer 20 act on the object by permeating through the contact layer 21 or by the dissolution of the contact layer 21 due to a predetermined factor. Therefore, the antibacterial components contained in the antibacterial layer 20 do not come into contact with the object all at once, thus preventing the antibacterial effect from disappearing quickly immediately after the thin film 10 is attached. In this way, the strong antibacterial effect in a short period of time is suppressed, so when the object is skin, it is possible to protect the skin from the effects of the antibacterial action and suppress skin irritation.

[0033] Furthermore, as with conventional methods, when products containing antibacterial components are in the form of a cream or liquid, it is difficult to precisely control the amount of product applied to the target. This can lead to excessive adhesion of the antibacterial component to the target, resulting in an overly strong antibacterial effect. In contrast, with the thin film 10 of this embodiment, the strength of the antibacterial effect acting on a predetermined area to which the thin film 10 is applied can be controlled by the amount of antibacterial component contained in the antibacterial layer 20. Therefore, excessive antibacterial action can be suppressed, and in particular, when the adherend is skin, it is possible to protect the skin from the effects of the antibacterial action and reduce skin irritation.

[0034] According to the thin film 10 of this embodiment, the antibacterial component acts slowly on the adherend, suppressing the growth of bacteria near the surface of the adherend, and as a result, the generation of odors caused by bacteria is suppressed. Furthermore, if the antibacterial layer 20 contains a fragrance component, the antibacterial layer 20 emits a fragrance, providing a masking effect against malodors, thereby enhancing the deodorizing effect.

[0035] Furthermore, because the functional components are retained in the thin antibacterial layer 20, the sustained release of the functional components is enhanced compared to cases where the functional components are contained in a cream or liquid. Therefore, the duration of the effects of the antibacterial and fragrance components is increased. Also, when creams or liquids are applied to the skin, the functional components may detach from the skin due to sweating or friction with clothing. In contrast, the thin film 10 of this embodiment can be left attached to the skin for a long time, which also enhances the duration of the effects of the antibacterial and fragrance components. Therefore, when the adherend is skin, the effect of extending the duration of the functional components' effects is particularly high.

[0036] As shown in Figure 2, the thin film 10 may also include a cover layer 22 in addition to the antibacterial layer 20 and the contact layer 21. The cover layer 22 covers the antibacterial layer 20 on the side opposite to the contact layer 21. That is, the antibacterial layer 20 is sandwiched between the contact layer 21 and the cover layer 22. When the thin film 10 is a laminate of the antibacterial layer 20, the contact layer 21 and the cover layer 22, the first surface 11F is the surface of the contact layer 21, and the second surface 11R is the surface of the cover layer 22.

[0037] In the above configuration, the cover layer 22 covers the antibacterial layer 20 on the substrate to which the thin film 10 is attached. Therefore, the functional components of the antibacterial layer 20 are prevented from escaping to the opposite side of the substrate, thereby increasing the duration of the effect of the functional components. If the antibacterial layer 20 contains fragrance components, the sustained release of the fragrance components is also increased.

[0038] A transfer sheet is used when attaching a thin film 10 to a substrate. As shown in Figure 3, the transfer sheet 30 comprises a thin film 10 and a support substrate 31 that supports the thin film 10. The second surface 11R of the thin film 10 is in contact with the support substrate 31.

[0039] The support base material 31 has the function of suppressing deformation of the thin film 10 when storing the thin film 10 or when moving the thin film 10 onto the adherend for use. Being supported by the support base material 31 makes the thin film 10 easier to handle.

[0040] Furthermore, the transfer sheet 30 may include a protective layer that covers the first surface 11F of the thin film 10. By including the protective layer, the thin film 10 is protected when stored.

[0041] The external shapes of the thin film 10 and the transfer sheet 30 in plan view are not particularly limited. The external shapes of the thin film 10 and the transfer sheet 30 may be, for example, polygonal shapes such as rectangles, circular shapes, elliptical shapes, or other shapes enclosed by straight lines or curves. In plan view, the shapes of the thin film 10 and the support substrate 31 may be the same, or the support substrate 31 may be larger than the thin film 10.

[0042] Incidentally, the skin has the function of protecting the body from the external environment by covering the outermost surface of the body, and is an important organ for maintaining homeostasis. On the other hand, abnormalities in skin homeostasis can easily occur due to external stimuli such as physical and chemical stimuli, as well as a decrease in the skin's ability to cope and endurance due to aging or internal organ diseases. If abnormalities in homeostasis become chronic, it can lead to a decrease in the stratum corneum and an increase or decrease in sebum production, potentially causing itching, redness, and pain due to peeling of the stratum corneum. One measure to maintain normal homeostasis is to moisturize the skin. Moisturizing the skin can be achieved by directly retaining moisture within the stratum corneum or by suppressing the amount of moisture that evaporates from the skin into the air. For these reasons, when the adherend is skin, it is preferable that moisturizing can be achieved in addition to antibacterial properties by attaching the thin film 10.

[0043] From the viewpoint of enhancing the moisturizing function of the thin film 10, it is preferable that the occlusion rate, a parameter indicating low gas permeability in the thin film 10, be between 5% and 70%. The occlusion rate is the ratio by which the amount of water evaporating at a location where the thin film 10 is placed is reduced compared to the amount of water evaporating when the thin film 10 is not placed. A high occlusion rate means that there are few permeable pathways for gas molecules within the thin film 10, that is, that water vapor does not easily permeate the thin film 10, and that functional components contained in the thin film 10 do not easily volatilize and escape from the thin film 10.

[0044] The occlusion rate is measured by the following method. (1) Circulate the warm water from the water bath, heated and kept at 37°C, into a tight box (manufactured by Sanplatec). Place a glass sample bottle into the tight box, and pour 37°C warm water into the glass sample bottle to a position 4 cm vertically away from the opening of the glass sample bottle.

[0045] (2) Place a plastic plate with a 10 mm diameter hole in the opening of the glass sample bottle in (1) above, cover the hole with a PTFE membrane filter (Merck Millipore, pore size: 10 μm, diameter: 25 mm, plain white), and leave it for 5 minutes.

[0046] (3) Using a transcutaneous water loss meter (ASCH JAPAN: VAPO SCAN AS-VT100RS), the probe is set to a diameter of 10 mm, and the amount of water lost at the position of the hole in the plastic plate after the operation in (2) above is measured on the membrane filter. The measured amount of water lost is taken as the initial value. The initial value corresponds to the amount of water lost when the thin film 10 is not placed.

[0047] (4) The thin film 10 is attached to the membrane filter as described in (2) above. That is, the transfer sheet 30 is placed on the membrane filter and the transfer sheet 30 is pressed down with a finger to attach the thin film 10 to the membrane filter, and the support substrate 31 is peeled off from the thin film 10. Then it is left for 5 minutes.

[0048] (5) Using the transcutaneous water evaporation meter described above, the amount of water evaporation at the position of the hole in the plastic plate after the operation in (4) is measured on the thin film 10, in the same manner as in (3), and the measured value is taken as the sample value. The sample value corresponds to the amount of water evaporation when the thin film 10 is in place. The occlusion rate is then calculated using the following formula (Equation 1). Occlusion rate (%) = (Initial value - Sample value) / Initial value × 100 ... (Equation 1)

[0049] If the occlusion rate is between 5% and 70%, then when the thin film 10 is applied to the skin, a good rate of transepidermal water loss can be obtained at the application site of the thin film 10. A good rate of transepidermal water loss means an amount equivalent to the rate of transepidermal water loss in the inner part of the forearm, which is healthy and has a low likelihood of skin irritation. By maintaining an appropriate rate of transepidermal water loss, the amount of moisture in the skin, such as the stratum corneum moisture content, is maintained at an appropriate level. As a result, the skin's barrier function and other functions are more likely to work normally, and skin homeostasis is more easily maintained.

[0050] Furthermore, because the thin film 10 is in film form, it reduces stickiness at the application site and minimizes the adhesion of ingredients to clothing, etc., compared to conventional cream or liquid moisturizing products.

[0051] In detail, if the occlusion rate is 5% or higher, the application of the thin film 10 suppresses the evaporation of water from the skin surface, thus enabling skin hydration. The higher the occlusion rate, the more effectively water evaporation from the skin surface is suppressed. For example, when the thin film 10 is used for cosmetic purposes, a occlusion rate of 15% or higher particularly enhances the skin's moisturizing effect. Furthermore, in medical applications, when the thin film 10 is used in moist wound healing, which improves the wound healing environment through moisture, or in occlusive dressing, which enhances drug penetration into the skin, a occlusion rate of 15% or higher allows for the application of the thin film 10 to suitably create a state of excessive moisture on the skin surface. Therefore, a good effect of promoting healing in a moist environment and enhancing drug penetration can be obtained. Note that the adherend in moist wound healing is not limited to the skin; it may also be an organ.

[0052] On the other hand, if the occlusion rate is 70% or less, the thin film 10 prevents excessive evaporation of moisture from the skin, thus suppressing the occurrence of redness and itching caused by dampness.

[0053] [Structure of each layer] The detailed structure of each layer of the thin film 10 and the transfer sheet 30 will be described below. (Antibacterial layer) The thickness of the antibacterial layer 20 is preferably 20 nm or more and less than 5000 nm. If the thickness of the antibacterial layer 20 is less than 5000 nm, the thickness of the thin film 10 is suppressed, thereby improving the adhesion between the thin film 10 and the adherend. Also, if the thickness of the antibacterial layer 20 is 20 nm or more, it is easier to incorporate a sufficient amount of functional components into the antibacterial layer 20. Furthermore, if the thickness of the antibacterial layer 20 is 20 nm or more, good strength of the antibacterial layer 20 is obtained, making it less likely for defects such as tearing to occur in the antibacterial layer 20. In addition, if the thickness of the antibacterial layer 20 is 20 nm or more, it is easy to form the antibacterial layer 20 in a continuous film-like manner.

[0054] The above-mentioned thickness of the antibacterial layer 20 is an average thickness, which is the average value of the film thickness of the antibacterial layer 20 measured at five or more measurement points by cross-sectional observation using a scanning electron microscope. If the antibacterial layer 20 contains solid matter such as powder that is insoluble in the coating liquid used to form the antibacterial layer 20, the measurement points are set in areas where no solid matter is present in the cross-section.

[0055] The antibacterial layer 20 contains a polymer material as its main component and a functional component containing an antibacterial component. The functional component may also contain an aromatic component along with the antibacterial component. The main component of the antibacterial layer 20 is the material with the largest mass in the antibacterial layer 20.

[0056] The polymer material included in the antibacterial layer 20 may be any material capable of forming the antibacterial layer 20 to the thickness within the range described above. When the adherend is skin, the polymer material is preferably a biocompatible material with low toxicity, skin irritation, and skin sensitization.

[0057] Examples of biocompatible polymer materials include polyesters such as polylactic acid, polyglycolic acid, and polycaprolactone, and their copolymers; resins used as film-forming agents in cosmetics, such as acrylic resins and silicones, and their copolymers; cellulose derivatives such as cellulose acetate, cellulose propionate acetate, and cellulose butyrate acetate; polycarbonate, cycloolefin copolymers, styrene-butadiene elastomers, and polyimides, which have a proven track record of use in medical devices.

[0058] Furthermore, proteins such as laminin, fibronectin, integrin, tenascin, albumin, keratin, collagen, and gelatin, and polysaccharides such as chitin, chitosan, hyaluronic acid, glucomannan, pullulan, dextran, and sacran may be used as materials for the antibacterial layer 20. Membranes made of proteins and polysaccharides often swell, dissolve, or decompose when exposed to water, but by forming a membrane by mixing cationic polymers and anionic polymers, or by stacking membranes of these polymers, an ion complex can be formed, thereby improving the water resistance of the membrane.

[0059] The antibacterial layer 20 may contain only one type of polymer material as described above, or it may contain multiple types. Furthermore, there are no particular restrictions on the molecular weight of the polymer material contained in the antibacterial layer 20; the polymer material contained in the antibacterial layer 20 may be one type of material having a predetermined average molecular weight, or it may contain multiple types of materials having different average molecular weights. In addition, the antibacterial layer 20 may be a single film or a laminate of multiple films.

[0060] The ratio of the total mass of antibacterial components contained in the antibacterial layer 20 to the total mass of the thin film 10 is preferably 50 ppm or more and 30% or less. Furthermore, if the functional components include both antibacterial components and fragrance components, the ratio of the total mass of functional components contained in the antibacterial layer 20 to the total mass of the thin film 10 is preferably 50 ppm or more and 30% or less. If the ratio of the mass of functional components is 50 ppm or more, the effects of the functional components, namely the antibacterial action of the antibacterial components and the fragrance effect of the fragrance components, are obtained well, and the persistence of the effects of the functional components is also obtained well. If the ratio of the mass of functional components is 30% or less, the excessive effect of the functional components is suppressed. Therefore, when the adherend is skin, the occurrence of skin irritation is suppressed.

[0061] When the adherend is a living organism, the antibacterial components contained in the antibacterial layer 20 include, for example, solvent-soluble sorbic acid, parachloromethacresol, 3-methyl-4-isopropylphenol, o-cymen-5-ol, phenyl salicylate, hexyl dimethylolpropionate, laurylisoquinolinium bromide, thianthol, parahydroxybenzoic acid esters, phenoxyethanol, chlorhexidine chloride, salicylic acid, photosensitizer 101, photosensitizer 201, photosensitizer 401, paradimethylaminostyrylheptylmethylthiazolium iodide, water-soluble hexachlorophene, and benzyl chloride. You can use materials such as ruconium, benzethonium chloride, N-cocoyl-L-arginine ethyl ester / pyrrolidone carboxylate, sodium benzoate, sodium salicylate, Candida bombicola / (glucose / rapeseed oil fatty acid methyl) ferment, chlorhexidine gluconate, chlorhexidine, potassium sorbate, 3-methyl-1,3-butanediol, resorcinol, trichlorocarban and other carvanilide compounds, antimicrobial metal materials such as copper and silver, organometallic compounds containing such metal materials, oxides of such metal materials, and materials in which such metal materials are supported on zeolite.

[0062] The antibacterial components may include ingredients effective in treating various diseases. Skin diseases include staphylococcal scalded skin syndrome, impetigo, molluscum contagiosum, athlete's foot, atopic dermatitis, seborrheic dermatitis, diaper rash, erythema multiforme, acne, erysipelas, gas gangrene, Kaposi's varicelliform eruption, candidal diaper dermatitis, candidal intertrigo, candidal interdigital erosion, Malassezia folliculitis, body odor, infectious vulvovaginitis, tinea cruris, erythrosclerosis, Examples include tinea manuum, folliculitis vulgaris, tinea corporis, paronychia, tinea capitis, cutaneous allergic vasculitis, cutaneous tuberculosis, mycobacterial infections, folliculitis, tinea versicolor, chronic pyoderma of the buttocks, cutaneous mycosis, juvenile flat warts, nontuberculous mycobacterial infections, herpes, Bowen's disease of the anal region, prodromal cancer, hair loss, sores, scalp eczema, cheilitis, toxic rash, punctate keratolysis, boils, and candidiasis. These diseases are known to be caused by bacteria, viruses, or fungi.

[0063] The bacteria, viruses, and fungi that cause the above-mentioned diseases include Staphylococcus aureus, Candida, Escherichia coli, various streptococci, Rickettsia, Propionibacterium acnes, various filamentous fungi, nontuberculous mycobacteria, Staphylococcus epidermidis, Klebsiella, Haemophilus influenzae prematurely, Clostridium perfringens, Corynebacterium minutisimum, molluscum contagiosum virus, herpes simplex virus, human papillomavirus, dermatophytes, Malassezia, and others. Antibacterial, antiviral, and antifungal agents for these include nadifloxacin, ozenoxacin, isoconazole nitrate, neticonazole hydrochloride, oxiconazole nitrate, hydrocortisone, diflucortolone valerate, tripesoside, lidocaine, sodium fusidate, penicillins, tetracyclines, mupirocin, cephalosporins, aminoglycosides, acyclovir, amphotericin, amorolfine hydrochloride, itraconazole, efficonazole, clotrimazole, ketoconazole, and sulconazole. Examples include zole nitrate, terbinafine hydrochloride, tolnaphthal, bifonazole, pimaricin, butenafine hydrochloride, miconazole nitrate, lanoconazole, liranaftate, luliconazole, fluconazole, ethacridine lactate, fentanyl, quinolones, tetracycline hydrochloride, acrinol, methyl parahydroxybenzoate, cefimbria, carbapenems, macrolides, lincomycins, fluoroquinolones, glycopeptides, salicylic acid, vidarabine, monochloroacetate, and activated vitamin D3.

[0064] When the adherend is not a living organism, the antibacterial components contained in the antibacterial layer 20 can include, for example, organic antibacterial agents such as alcohol-based, phenol-based, aldehyde-based, carboxylic acid-based, ester-based, ether-based, nitrile-based, peroxide / epoxy-based, halogen-based, pyridine / quinoline-based, triazine-based, isothiazolone-based, imidazole / thiazole-based, anilide-based, biguanide-based, disulfide-based, thiocarbamate-based, surfactant-based, and organometallic-based materials.

[0065] Alcohol-based antibacterial components include, for example, ethyl alcohol, propyl alcohol, 2-propanol, 2-bromo-2-nitro-1,3-propanediol, and N-(-2-hydroxypropyl)-aminomethanol. Phenolic antibacterial components include, for example, phenol, 3-methyl-4-isopropylphenol, 2-isopropyl-5-methylphenol, orthophenylphenol, sodium orthophenylphenol, 4-chloro-2-(phenylmethyl)phenol, and monochloro-2-phenylphenol. Aldehyde-based antibacterial components include, for example, formaldehyde, glutaraldehyde, and α-bromocinnamaldehyde.

[0066] Examples of carboxylic acid-based antimicrobial components include benzoic acid, sodium benzoate, zinc 10-undecylenate, monoethanolamide 10-undecylenate, octanoic acid, hexadienic acid, potassium hexadienate, propionic acid, potassium propionate, calcium propionate, and sodium propionate. Examples of ester-based antimicrobial components include glycerin fatty acid esters, methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, and butyl parahydroxybenzoate. An example of an ether-based antimicrobial component is 2,4,4'-trichloro-2'-hydroxydiphenyl ether.

[0067] Examples of nitrile-based antimicrobial components include 2,4,5,6-tetrachloroisophthalonitrile and 1,2-dibromo-2,4-dicyanovutane. Examples of peroxide / epoxy-based antimicrobial components include hydrogen peroxide, ethylene oxide, propylene oxide, and peracetic acid. Examples of halogen-based antimicrobial components include polyvinylpyrrolidone iodine, parachlorophenyl-3-iodopropagyl formal, 3-iodo-2-propagyl butylcarbamate, chlorinated isocyanuric acid, 1-[(diiodomethyl)sulfonyl]-4-methylbenzene, N-(fluorodichloromethio)-phthalimide, N,N-dimethyl-N'(dichlorofluoromethylthio)-N'phenylsulfamide, 1-bromo-3-ethoxycarboxy-1,2-diiodo-1-propene 2,3,3-triiodaryl alcohol, and α-chloronaphthalene.

[0068] Examples of pyridine / quinoline-based antimicrobial agents include 8-oxyquinoline, 2,3,5,6-tetrachlor-4-(methylsulfonyl)pyridine, and bis(2-pyridylthio-1-oxide)sodium. Examples of triazine-based antimicrobial agents include N,N',N''-trishydroxyethylhexadro-S-triazine. Examples of isothiazolone-based antimicrobial agents include 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, and 1,2-benzothiazolon. Examples of imidazole / thiazole-based antimicrobial agents include 2-(4-thiocyanomethylthio)bentzimidazole, 2-(4'-thiozolyl)bentzimidazole, and 2-methoxycarbonylaminobentzimidazole.

[0069] Examples of anilide-based antimicrobial agents include 3,4,4'-trichlorocarbanilide and 3-trifluoromethyl-4,4'-dichlorocarbanilide. Examples of biguanide-based antimicrobial agents include polyhexamethylene biguanidine hydrochloride, chlorhexidine gluconate, and chlorhexidine hydrochloride. Examples of disulfide-based antimicrobial agents include bis(dimethylthiocarbamoyl) disulfide. Examples of thiocarbamate-based antimicrobial agents include ammonium-N-methyldithiocarbamate and sodium-N-methyldithiocarbamate.

[0070] Examples of surfactant-based antibacterial components include alkyldimethylbenzylammonium chloride, didecyldimethylammonium chloride, cetyldimethylbenzylammonium chloride, octadecylamine acetate, 3-(terimethoxysilyl)propyldimethyloctadecylammonium chloride, poly[polymethylene(dimethyliminio)chloride], poly[oxyethylene(dimethyliminio)ethylene(dimethyliminio)ethylenedichloride], alkyl(diaminoethyl)glycine hydrochloride, ethylpyridinium chloride, and dodecylpyridinium chloride. Examples of organometallic antibacterial components include 10,10'-oxybisphenoxarcin, zinc naphthenate, copper naphthenate, and 8-oxyquinoline copper.

[0071] Furthermore, if the adherend is not a living organism, inorganic antibacterial agents or naturally derived antibacterial agents may be used as the antibacterial component. Examples of inorganic antibacterial agents include silicate materials such as zeolite (aluminosilicate), magnesium aluminometasilicate, and calcium silicate; phosphate materials such as zirconium phosphate, calcium phosphate, and calcium phosphate double salt; oxide materials such as silica, silica gel, zinc oxide, and alkaline earth metal (water) oxides; glass materials such as soluble glass and composite glass; inorganic / organic composite materials such as layered phosphate-quaternary ammonium; oxide photocatalytic materials such as titanium dioxide; and potassium titanate.

[0072] Examples of naturally derived antibacterial agents include animal and fish-derived materials such as chitin, chitosan, propolis, and protamine; microbial and actinomycete-derived materials such as amino acid glycosides and polylysine; enzyme-derived materials such as lysozyme; plant-derived materials such as hinokitiol, mugwort extract, aloe extract, perilla leaf extract, houttuynia cordata, licorice, tea, green tea, mustard extract, wasabi extract, and bamboo extract; natural sulfur-derived materials such as natural sulfur; and natural ore-derived materials such as natural minerals, ceramics, and natural radioactive rare minerals.

[0073] The fragrance components included in the antibacterial layer 20 are compounds that emit fragrance. Examples of such compounds include acetals, alcohols, aldehydes, ethers, esters, carboxylic acids, glycols, ketones, nitrogen compounds, nitro compounds, phenylpropanoids, phenols, lactones, and halogenated hydrocarbons. In addition, aliphatic hydrocarbons and aromatic hydrocarbons that emit fragrance other than those listed above may be used as fragrance components.

[0074] Aromatic components of acetals include, for example, phenylacetaldehyde dimethyl acetal, hydratropaldehyde dimethyl acetal, and [S,(-)]-7-hydroxy-3,7-dimethyloctanal dimethyl acetal. Aromatic components of alcohols include, for example, nerol, borneol, geraniol, citronellol, farnesol, nerolidol, furfuryl alcohol, fencol, 2-octanol, 2-heptanol, linalool, benzyl alcohol, 1-octanol, isopulegol, 1-menthol, phenylethyl alcohol, terpineol, pelargol, nonanol, 3-phenyl-1-propanol, 1-decanol, phenoxyethanol, santalol, 10-undecen-1-ol, 1-undecanol, cinnamyl alcohol, cedrol, bisabolol, and 1-dodecanol.

[0075] Aromatic components of aldehydes include, for example, hydroxycitronellal, octanal, salicylaldehyde, heptanal, phenylethenal, nonanal, citronellal, 2-phenylpropionaldehyde, decanal, phenylpropionaldehyde, undecanal, citral, 2-methylundecanal, anisaldehyde, cinnamaldehyde, dodecanal, cyclamenaldehyde, citronellyloxyacetaldehyde, piperonal, α-hexylcinnamaldehyde, vanillin, ethyl vanillin, and cuminaldehyde. Aromatic components of ethers include, for example, diphenyl ether, 2-methoxynaphthalene, safrole, isosafrole, isoeugenol methyl ether, 2-ethoxynaphthalene, cineole, and benzyl isoamyl ether.

[0076] Aromatic components of esters include, for example, geranyl acetate, ethyl 3-methyl-3-phenyloxiran-2-carboxylate, amyl butyrate, ethyl acetoate, ethyl heptanoate, heptyl formate, octyl formate, methyl benzoate, benzyl formate, bornyl formate, ethyl benzoate, phenylethyl acetate, diethyl succinate, octyl acetate, linalyl formate, ethyl phenyl, benzyl acetate, methyl formate, methyl salicylate, phenylethyl formate, Methyl 2-octyl acetate, p-tolyl acetate, linalyl acetate, nonyl acetate, bornyl acetate, isobornyl acetate, ethyl nonanoate, menthyl acetate, isobornyl propionate, bornyl propionate, ethyl propionate, benzyl propionate, terpinyl acetate, isobutyl benzoate, phenethyl acetate, linalyl propionate, geranyl formate, citronellyl acetate, bicycloisobutyrate, vertenex, phenethyl propionate Linalyl isobutyrate, citronellyl propionate, phenethyl isobutyrate, benzyl isobutyrate, isobutyl phenylacetate, geranyl propionate, diethyl DL-malate, 3-phenylpropyl acetate, isoamyl benzoate, isobutyl salicylate, benzyl isovalerate, isoamyl phenylacetate, methyl cinnamate, amyl benzoate, 4-methoxybenzyl acetate, cinnamyl acetate, methyl 10-undecenoate, 3,7-dimethyl isobutyrate These are tyl-6-octenyl, ethyl cinnamate, dimethyl phthalate, diethyl l-(+)-tartrate, geranyl isobutyrate, ethyl 10-undecenoate, isoamyl salicylate, eugenol acetate, isobutyl cinnamate, benzyl phenylacetate, geranyl tigrate, triethyl citrate, diethyl phthalate, benzyl benzoate, 2-phenylethyl phenylacetate, benzyl salicylate, benzyl cinnamate, linalyl acetate, and ethyl furoate.

[0077] Aromatic components of carboxylic acids include, for example, phenylacetic acid, cinnamic acid, and benzoic acid. Aromatic components of glycols include, for example, propylene glycol and dipropylene glycol. Aromatic components of ketones include, for example, carvone, α-ionone, β-ionone, 2-undecanone, 2-butanone, D-fencone, thujone, menthone, acetophenone, camphor, pulegone, methylacetophenone, acetanisole, benzylideneacetone, α-methylionone, exalton, muscone, benzophenone, 2'-acetonaphthone, cis-jasmone, and sedanolide.

[0078] Aromatic compounds that are nitrogen compounds include, for example, 6-methylquinoline, methyl N-methylanthranilate, methyl anthranilate, indole, and skatole. Aromatic compounds that are nitro compounds include, for example, musk ambrette, muscoxyl, and musk ketone. Aromatic compounds that are phenylpropanoids include, for example, methyl eugenol, estragole, anethole, eugenol, and isoeugenol. Aromatic compounds that are phenols include, for example, thymol, dimethylhydroquinone, ethyl salicylate, and carvacrol. Aromatic compounds that are lactones include, for example, γ-undecalactone, γ-nonanolactone, coumarin, 6-methylcoumarin, and cyclopentadecanol. Aromatic compounds that are halogenated hydrocarbons include, for example, bromostyrol and α-trichloromethylbenzyl acetate.

[0079] Aromatic compounds that are aliphatic hydrocarbons other than those mentioned above include, for example, caryophyllene, α-cadinene, limonene, and cedrene. Aromatic compounds that are aromatic hydrocarbons other than those mentioned above include, for example, diphenylmethane.

[0080] The antibacterial layer 20 may also contain compounds that are both antibacterial and aromatic. For example, compounds such as benzoic acid, thymol, and carvacrol function as both antibacterial and aromatic components.

[0081] Furthermore, the antibacterial layer 20 may contain additives that exhibit a predetermined function on the adherend, in addition to the functional components of antibacterial and aromatic components. When the adherend is skin, the additives may be, for example, cosmetics or cosmetic components used in skincare such as moisturizing creams and serums, pigments, drugs, proteins, and enzymes. The antibacterial layer 20 may contain only one type of additive, or it may contain two or more types of additives.

[0082] (contact layer) The thickness of the contact layer 21 is preferably 10 nm or more and 1000 nm or less. If the thickness of the contact layer 21 is 1000 nm or less, the conformability of the first surface 11F to the surface shape of the adherend is improved. Also, if the thickness of the contact layer 21 is 1000 nm or less, the antibacterial components contained in the antibacterial layer 20 reach the adherend more effectively. Furthermore, if the thickness of the contact layer 21 is 10 nm or more, good strength of the contact layer 21 is obtained, making it less likely for defects such as tears to occur in the contact layer 21. In addition, if the thickness of the contact layer 21 is 10 nm or more, it is easy to form the contact layer 21 in a continuous film shape.

[0083] The above-mentioned thickness of the contact layer 21 is an average thickness, which is the average value of the film thickness of the contact layer 21 measured at five or more measurement points by cross-sectional observation using a scanning electron microscope. If the contact layer 21 contains solid matter such as powder that is insoluble in the coating liquid used to form the contact layer 21, the measurement points are set in areas where no solid matter is present in the cross-section.

[0084] The contact layer 21 is preferably thinner than the antibacterial layer 20. This prevents the contact layer 21, which has the function of slowing down the arrival of the antibacterial components to the substrate, from becoming too thick relative to the amount of antibacterial components contained in the antibacterial layer 20, so that the contact layer 21 has a thickness suitable for its function. Therefore, the function of the contact layer 21 is effectively performed. In other words, the antibacterial components contained in the antibacterial layer 20 act on the substrate at an appropriate rate and for an appropriate duration.

[0085] Furthermore, the thinner the contact layer 21, the greater the flexibility near the first surface 11F, thereby improving the conformability of the first surface 11F to the surface shape of the adherend. Therefore, in a thin film 10 of a certain total thickness, the thinner the contact layer 21 is compared to the antibacterial layer 20, the greater the adhesion between the thin film 10 and the adherend, and if the adherend is skin, the feeling of tightness in the skin at the part where the thin film 10 is attached is suppressed. In addition, a higher antibacterial layer 20 than the contact layer 21 makes it easier to obtain a good occlusion rate and enhances the moisturizing effect.

[0086] The contact layer 21 contains a polymer material as its main component. The polymer material contained in the contact layer 21 may be any material capable of forming the contact layer 21 to the thickness within the range described above. When the adherend is skin, the polymer material is preferably a biocompatible material with low toxicity, skin irritation, and skin sensitization. Furthermore, when the adherend is skin, the polymer material that is the main component of the contact layer 21 is preferably a water-soluble polymer material. The main component of the contact layer 21 is the material with the largest mass in the contact layer 21.

[0087] If the main component of the contact layer 21 is a water-soluble polymer material, the contact layer 21 dissolves when moisture such as sweat is generated on the skin, and the action of the antibacterial component contained in the antibacterial layer 20 on the skin is promoted. When sweat is generated, bacteria tend to multiply around the skin, and as a result, unpleasant odors are more likely to occur. By promoting the action of the antibacterial component on the skin due to the generation of sweat, the antibacterial action works on the skin at the appropriate time, and the generation of odor is effectively suppressed.

[0088] Furthermore, when the occlusion rate is between 5% and 70%, moisture generated from the skin is retained between the contact layer 21 and the skin surface, allowing for proper dissolution of the contact layer 21, thus enabling the antibacterial effect to work more effectively.

[0089] Examples of water-soluble polymers used in the contact layer 21 include natural synthetic polymers such as starches like dextrin, amylose, and amylopectin; cellulose derivatives such as alkylcellulose, carboxyalkylcellulose, carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxyalkylcellulose, and cellulose proleonate acetate; polysaccharides such as dextran, pullulan, chitosan, carrageenan, sodium alginate, pectin, sodium hyaluronate, xanthan gum, and sodium guar gum chondroitin sulfate; proteins such as elastin, albumin, transferrin, globulin, and sodium caseinate; semi-synthetic polymers such as cationized guar gum; and synthetic polymers such as carboxyvinyl polymer, polyacrylic acid, polyvinylpyrrolidone, and polyvinyl alcohol. In particular, dextrin, amylose, alkylcellulose, pullulan, chitosan, sodium alginate, pectin, sodium hyaluronate, xanthan gum, guar gum chondroitin sulfate sodium, elastin, transferrin, sodium caseinate, and polyvinyl alcohol are preferable because they dissolve easily in water at temperatures close to body temperature, and their use promotes the dissolution of the contact layer 21 when sweat is produced.

[0090] (Cover layer) The thickness of the cover layer 22 is preferably between 10 nm and 1000 nm. If the thickness of the cover layer 22 is 1000 nm or less, the thickness of the thin film 10 is suppressed, thereby improving the adhesion between the thin film 10 and the adherend. Also, if the thickness of the cover layer 22 is 10 nm or more, good strength of the cover layer 22 is obtained, making it less likely for defects such as tearing to occur in the cover layer 22. Furthermore, if the thickness of the cover layer 22 is 10 nm or more, it is easy to form the cover layer 22 in a continuous film shape.

[0091] The thickness of the cover layer 22 is an average thickness, which is the average value of the film thickness of the cover layer 22 measured at five or more measurement points by cross-sectional observation using a scanning electron microscope. If the cover layer 22 contains solid matter such as powder that is insoluble in the coating liquid used to form the cover layer 22, the measurement points are set in areas where no solid matter is present in the cross-section.

[0092] The cover layer 22 is preferably thinner than the antibacterial layer 20. This ensures that the cover layer 22 has a thickness suitable for its function of suppressing the diffusion of functional components contained in the antibacterial layer 20 to the outside.

[0093] The cover layer 22 contains a polymer material as its main component. Any known polymer material can be used for the cover layer 22, as long as it is a material capable of forming the cover layer 22 to the thickness described above. Examples of materials for the cover layer 22 include polyesters such as polylactic acid, polyglycolic acid, and polycaprolactone and their copolymers; resins used as film-forming agents in cosmetics, such as acrylic resins and silicones, and their copolymers; cellulose derivatives such as cellulose acetate, cellulose propionate acetate, and cellulose butyrate acetate; polycarbonate, cycloolefin copolymer, styrene-butadiene elastomer, polyimide, polyolefin, polyamide, polyvinyl alcohol, polyurethane, polyvinyl acetate, polyvinyl chloride, polyvinylidene chloride, polysiloxanes, cellulose, casein and other proteins, rubber, derivatives, modified forms, copolymers, and mixtures of these polymer compounds. Furthermore, as the material for the cover layer 22, it is acceptable to select a material from among the materials exemplified above that is less likely to delaminate from the antibacterial layer 20 and that can form a cover layer 22 that suppresses the volatilization of functional components contained in the antibacterial layer 20.

[0094] The cover layer 22 may contain a fragrance component. As the fragrance component, the above-mentioned compounds, which are examples of fragrance components that can be contained in the antibacterial layer 20, can be used. Because the cover layer 22 contains a fragrance component, when the thin film 10 is attached to the substrate, the fragrance is emitted from the outermost layer on the opposite side of the substrate, i.e., the layer that is exposed to the outside air. Therefore, the masking effect of malodorous odors is enhanced, and thus the deodorizing effect is enhanced.

[0095] (Supporting base material) The material of the support substrate 31 is not particularly limited. The support substrate 31 is preferably, for example, a polymer film, a woven fabric, a knitted fabric, a nonwoven fabric, or paper.

[0096] Materials for the polymer film used in the support substrate 31 include polyester, polyolefin, polyamide, polyimide, polyvinyl alcohol, polyurethane, polyvinyl acetate, polyvinyl chloride, polyvinylidene chloride, polycarbonate, acrylic resin, polysiloxanes, cellulose, casein, and various other proteins, rubber, derivatives, modified forms, copolymers, and mixtures of these polymer compounds. The polymer film used as the support substrate 31 may be a film that has been processed by embossing, perforation, foaming, or other methods to create a porous structure.

[0097] The woven, knitted, and nonwoven fabrics used in the support base material 31 are composed of natural or chemical fibers. Natural fibers may include cotton, linen, pulp, wool, silk, etc. Chemical fibers may include polyester, polyolefin, cupro, rayon, lyocell, acetate, diacetate, nylon, aramid, acrylic, etc. The support base material 31 may also be composed of a fibrous material which is a mixture of natural and chemical fibers. Such a fibrous material support base material 31 may be subjected to processing such as embossing, perforation, or foaming to create porosity in the fibers.

[0098] If the support base material 31 is made of fibrous material, the basis weight of the support base material 31 is 3 g / m². 2More than 200g / m 2 Preferably, it is 10 g / m 2 More than 100g / m 2 The following is more preferable: If the basis weight of the support substrate 31 is above the lower limit, the support substrate 31 has sufficient rigidity to prevent deformation such as twisting caused by static electricity or airflow, making the thin film 10 easier to handle. Also, if the basis weight of the support substrate 31 is below the upper limit, the fibers in the support substrate 31 are not too densely packed, so when using a transfer method in which the support substrate 31 is moistened and peeled off from the thin film 10 when using the transfer sheet 30, the support substrate 31 can absorb liquid smoothly, and the transfer can be performed effectively.

[0099] When the supporting substrate 31 is made of a fibrous material, the method of manufacturing the fibrous material is not particularly limited. For example, a fibrous material produced by using a spunlace method, thermal bond method, chemical bond method, etc., on a web made by a wet or dry method such as a spunbond method, meltblown method, airlaid method, or flash spinning method, can be appropriately selected and used. Furthermore, the various substrates described above as examples for the support substrate 31 can be used as the protective layer. The materials of the protective layer and the support substrate 31 may be the same or different.

[0100] [Method for manufacturing thin films and transfer sheets] Each layer of the thin film 10 is formed by a known thin-film formation method. For example, a solution casting method can be used, in which a coating liquid containing the material of the layer to be formed is applied to a substrate in a thin film form and then the solvent is evaporated, or a melt extrusion method can be used, in which molten material is extruded to form a thin film. The method for forming each layer can be selected according to the material of each layer. For example, the solution casting method is preferably used for forming each layer.

[0101] In the solution casting method, a coating solution is formed by dissolving the material of the layer to be formed in a solvent. A coating film is formed when the coating solution is applied to the surface of a substrate for film formation, and a thin film layer is formed when the coating film dries. Depending on the properties of the material of the layer to be formed, a non-polar solvent, a protic polar solvent, or an aprotic polar solvent can be used as the solvent for the coating solution. Examples of non-polar solvents include benzene and hexane. Examples of protic polar solvents include water, ethanol, isopropyl alcohol, and acetic acid. Examples of aprotic polar solvents include ethyl acetate, butyl acetate, propyl acetate, ethyl methyl ketone, acetone, and dimethyl sulfoxide.

[0102] The method of applying the coating solution is not particularly limited as long as it is a method that can form a coating film of the desired thickness. Various coating methods can be used, such as direct gravure, reverse gravure, small-diameter reverse gravure, Meyer coating, die coating, curtain coating, spray coating, spin coating, screen printing, comma coating, knife coating, gravure offset coating, and roll coating.

[0103] When forming each layer using the solution casting method, a contact layer 21 is formed on the surface of the film-forming substrate, and then an antibacterial layer 20 is formed on top of the contact layer 21. If a cover layer 22 is to be provided, the cover layer 22 is further formed on top of the antibacterial layer 20. Then, a support substrate 31 is laminated onto the thin film 10, which is a laminate on the film-forming substrate, and the transfer sheet 30 can be formed by peeling off the film-forming substrate. If a protective layer is to be provided, the protective layer can be placed on the surface of the contact layer 21 after peeling off the film-forming substrate.

[0104] [Transfer sheet housing] Figure 4 shows a container in which the transfer sheet 30 is housed. The transfer sheet container 40 comprises a transfer sheet 30 having a protective layer and a packaging body 41 that houses the transfer sheet 30.

[0105] To prevent the functional components of the thin film 10 from diffusing to the outside before the transfer sheet 30 is used, the packaging 41 is preferably configured to be airtight. The packaging 41 has a bag-like shape formed from, for example, a polymer film. The polymer film can be, for example, a single-layer or multi-layer film made of polyolefin, polyester, polyacrylonitrile, nylon, etc. Furthermore, the packaging 41 may have a gas barrier layer laminated on the polymer film, consisting of at least one of organic and inorganic materials. The gas barrier layer helps to suppress the volatilization of the functional components of the thin film 10. It is also preferable that the material of the packaging 41 is one that does not easily adsorb functional components.

[0106] [How to use the transfer sheet] When using the transfer sheet 30, first, the transfer sheet 30 is placed on the adherend so that the adherend and the first surface 11F of the thin film 10 are in contact, that is, so that the adherend and the contact layer 21 are in contact. Then, the support substrate 31 is peeled off from the thin film 10. As a result, the thin film 10 is transferred to the adherend.

[0107] A liquid such as water or lotion may be supplied to the surface of the adherend before the transfer sheet 30 is applied, or to the support substrate 31 after the transfer sheet 30 has been applied. In this case, the liquid penetrates the transfer sheet 30, which promotes the separation of the thin film 10 from the support substrate 31.

[0108] Furthermore, the supply of the liquid material promotes the dissolution of the contact layer 21, thereby accelerating the arrival of the antibacterial components to the substrate. Even if the contact layer 21 dissolves immediately after the thin film 10 is applied and the antibacterial effect on the substrate is exerted, the presence of dissolved material from the contact layer 21 between the thin film 10 and the substrate prevents the antibacterial effect from becoming too strong and disappearing too quickly, compared to the case where the antibacterial layer 20 is in direct contact with the substrate.

[0109] Furthermore, the use of the thin film 10 is not particularly limited, and the thin film 10 can be used for a variety of purposes, including cosmetic and medical applications. The purpose of using the thin film 10 only needs to include antibacterial action, that is, suppressing the growth of bacteria near the surface of the adherend, and deodorization is not required.

[0110] [Examples] The thin film and transfer sheet described above will be explained using specific examples and comparative examples.

[0111] (Example 1) High-purity polyvinyl alcohol (manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) was dissolved in pure water to prepare a polyvinyl alcohol solution with a solid content of 2.5%, which was used as a coating solution for forming the contact layer. The average molecular weight of the polyvinyl alcohol used in the coating solution was selected to be 400,000. Poly-DL-lactic acid (manufactured by Musashino Chemical Research Institute Co., Ltd.) was dissolved in ethyl acetate to prepare a polylactic acid solution with a solid content of 6%. The average molecular weight of the poly-DL-lactic acid was selected to be 100,000. Furthermore, isopropylmethylphenol was added to the polylactic acid solution as an antibacterial component to prepare a coating solution for forming the antibacterial layer. The amount of antibacterial component added was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0112] A coating solution for forming a contact layer was applied to a PET sheet, which serves as a substrate for film formation, using a wire bar, to form a coating film with a thickness of 300 nm after drying. The coating film was then heated in a circulating oven set to 80°C for 1 minute to dry and solidify, thereby forming the contact layer. Subsequently, a coating solution for forming an antibacterial layer was applied to the contact layer using a wire bar, to form a coating film with a thickness of 300 nm after drying. The coating film was then heated in a circulating oven set to 80°C for 1 minute to dry and solidify, thereby forming the antibacterial layer. As a result, a thin film comprising a contact layer and an antibacterial layer was formed on the substrate for film formation.

[0113] Next, a nonwoven fabric (manufactured by Futamura Chemical Co., Ltd.) was laminated on top of the antibacterial layer as a support substrate. The film-forming substrate was then peeled off, and the thin film was transferred from the film-forming substrate to the support substrate. The main component of the nonwoven fabric used as the support substrate was cellulose derived from pulp, and the basis weight of the nonwoven fabric was 20 g / m². 2 This resulted in obtaining the transfer sheet of Example 1, which comprises a support substrate and a thin film.

[0114] (Example 2) The transfer sheet of Example 2 was obtained using the same materials and process as in Example 1, except that the coating film was formed so that the thickness of the antibacterial layer was 600 nm. The amount of antibacterial component added to the coating solution for forming the antibacterial layer was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0115] (Example 3) The transfer sheet of Example 3 was obtained using the same materials and process as in Example 1, except that the coating film was formed so that the antibacterial layer thickness was 1200 nm. The amount of antibacterial component added to the coating solution for forming the antibacterial layer was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0116] (Example 4) The transfer sheet of Example 4 was obtained using the same materials and process as in Example 1, except that a coating film was formed so that the contact layer thickness was 600 nm and the antibacterial layer thickness was 600 nm. The amount of antibacterial component added to the coating solution for forming the antibacterial layer was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0117] (Example 5) The transfer sheet of Example 5 was obtained using the same materials and process as in Example 1, except that a coating film was formed so that the contact layer thickness was 600 nm and the antibacterial layer thickness was 1200 nm. The amount of antibacterial component added to the coating solution for forming the antibacterial layer was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0118] (Example 6) The transfer sheet of Example 6 was obtained using the same materials and process as in Example 1, except that a coating film was formed so that the contact layer thickness was 1200 nm and the antibacterial layer thickness was 3000 nm. The amount of antibacterial component added to the coating solution for forming the antibacterial layer was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0119] (Example 7) The transfer sheet of Example 7 was obtained using the same materials and process as in Example 1, except that the coating film was formed so that the thickness of the contact layer was 1200 nm. The amount of antibacterial component added to the coating solution for forming the antibacterial layer was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0120] (Example 8) The transfer sheet of Example 8 was obtained using the same materials and process as in Example 1, except that a coating film was formed so that the thickness of the contact layer was 1200 nm and a coating film was formed so that the thickness of the antibacterial layer was 1200 nm. The amount of antibacterial component added to the coating solution for forming the antibacterial layer was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0121] (Comparative Example 1) A coating solution for forming the antibacterial layer was prepared in the same manner as in Example 1. The amount of antibacterial component added was adjusted so that the mass ratio of the antibacterial component to the total thin film to be formed was 0.5%. The coating solution was applied to a PET sheet, which was used as the substrate for film formation, using a wire bar, and a coating film was formed with a film thickness of 600 nm after drying. The coating film was then heated in a circulating oven set to 80°C for 1 minute to dry and solidify, thereby forming the antibacterial layer. As a result, a thin film was formed on the substrate for film formation that had only the antibacterial layer and no contact layer.

[0122] Next, a nonwoven fabric (manufactured by Futamura Chemical Co., Ltd.) was laminated onto the thin film as a support substrate, and the film-forming substrate was peeled off to transfer the thin film from the film-forming substrate to the support substrate. The composition and basis weight of the nonwoven fabric used as the support substrate were the same as in Example 1. This yielded a transfer sheet of Comparative Example 1 comprising a support substrate and a thin film.

[0123] (Comparative Example 2) A coating solution for forming the contact layer was prepared with the same composition as in Example 1, and isopropylmethylphenol was added to the coating solution as an antibacterial component. The amount of antibacterial component added was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0124] The above coating liquid was applied to a PET sheet, which served as a substrate for film formation, using a wire bar, and a coating film was formed with a drying thickness of 600 nm. The coating film was then heated in a circulating oven set to 80°C for 1 minute to dry and solidify, thereby forming a contact layer. As a result, a thin film was formed on the substrate for film formation, comprising only a contact layer, with the contact layer containing an antibacterial component. In other words, the thin film of Comparative Example 2 can be considered to have a layer formed from a material in which the antibacterial component has been added to the contact layer material of each example, as a standalone antibacterial layer.

[0125] Next, a nonwoven fabric (manufactured by Futamura Chemical Co., Ltd.) was laminated onto the thin film as a support substrate, and the film-forming substrate was peeled off to transfer the thin film from the film-forming substrate to the support substrate. The composition and basis weight of the nonwoven fabric used as the support substrate were the same as in Example 1. This yielded a transfer sheet of Comparative Example 2 comprising a support substrate and a thin film.

[0126] (Comparative Example 3) The transfer sheet of Comparative Example 3 was obtained using the same materials and process as in Example 1, except that the coating solution for forming the antibacterial layer was prepared without adding any antibacterial components. In other words, the thin film of Comparative Example 3 does not contain any antibacterial components in either of its two layers.

[0127] (Comparative Example 4) A transfer sheet of Comparative Example 4 was obtained using the same materials and process as in Example 1, except that a coating film was formed so that the contact layer thickness was 2500 nm and the antibacterial layer thickness was 3000 nm. The amount of antibacterial component added to the coating solution for forming the antibacterial layer was adjusted so that the mass ratio of the antibacterial component to the entire thin film to be formed was 0.5%.

[0128] (Measurement of occlusion rate) For each example and each comparative example, the occlusion rate was calculated using (Equation 1) above, according to the measurement method described in the above embodiment.

[0129] (Evaluation of antibacterial function) For each example and comparative example, the antibacterial function of the thin film was evaluated by observing the state of bacterial growth when the thin film was attached to a culture medium, and by observing the condition of human skin over time when the thin film was attached to human skin.

[0130] <Observation of bacterial growth in culture medium> For each example and comparative example, five test pieces were prepared by cutting a transfer sheet into a circular shape with a diameter of 30 mm. Then, for each test piece, a sample was prepared by attaching a thin film to the culture medium according to the following procedures (1) to (4), and the state of bacterial growth was observed.

[0131] (1) Prepare a liquid culture medium of Pearlcore Tryptosoy Broth Medium (manufactured by Eiken Chemical Co., Ltd.), and use this medium to culture Staphylococcus aureus overnight in a constant temperature bath set to 35°C as a pre-culture. Also, prepare an agar medium of Pearlcore Standard Agar Medium (manufactured by Eiken Chemical Co., Ltd.) in a petri dish with a diameter of 10 cm as the culture medium for the main culture.

[0132] (2) Add 100 μL of the bacterial suspension obtained by pre-culture to the agar plate and spread the bacterial suspension evenly over the entire agar plate using a convection rod. (3) Place the test piece on the agar medium coated with the bacterial suspension so that the thin film is in contact with the agar medium. Allow the support substrate to swell with the moisture in the medium, and slowly peel off the support substrate from the edge. This creates a sample with the thin film attached to the medium.

[0133] (4) Place the sample prepared in (3) above in a constant temperature bath set to 35°C and culture for one day, then visually determine whether bacterial growth has been suppressed. When visually observing, storing the culture medium in a refrigerator at 3°C ​​for about 10 minutes will make it easier to determine whether bacterial growth has been suppressed.

[0134] In evaluating the antibacterial function, for each example and comparative example, if no bacterial growth was observed in any of the five samples, i.e., if inhibition of bacterial growth was confirmed, it was marked as "○"; if inhibition of bacterial growth was confirmed in three or four samples, it was marked as "△"; and if inhibition of bacterial growth was confirmed in two or fewer samples, it was marked as "×".

[0135] <Monitoring the skin condition> For each example and comparative example, a test specimen was prepared by cutting a transfer sheet into a circular shape with a diameter of 30 mm. Then, a thin film was attached to human skin according to the procedure described below, and the progress was observed.

[0136] After wiping the inside of the subject's forearm with a damp cloth, the test piece of the transfer sheet is placed so that the thin film is in contact with the skin. Once it is confirmed that the color of the support substrate changes due to water absorption, the support substrate is peeled off from the edge. This leaves the thin film on the skin, completing the application of the thin film. After a predetermined time has elapsed since application, it is determined whether there is any dampness or tightness of the skin in the area where the thin film is applied. Furthermore, the thin film is peeled off and the skin color is observed to determine whether redness and itching have occurred.

[0137] The above evaluations were performed on five test specimens for each example and comparative example, after 1 hour, 3 hours, and 6 hours. In the evaluation, "○" was given if no abnormalities such as redness, itching, stuffiness, or skin tightness occurred at the application site of the thin film on all five test specimens; "△" was given if none of the above abnormalities occurred on three or four test specimens; and "×" was given if two or fewer test specimens showed none of the above abnormalities.

[0138] (Evaluation of moisturizing function) For each example and comparative example, a test specimen was prepared by cutting a transfer sheet into a circular shape with a diameter of 30 mm. Then, for each test specimen, a thin film was attached to human skin according to the following procedures (1) to (4), and the moisturizing function was evaluated.

[0139] (1) The forearm of the subject will be used as the test site. After washing the test site with water, the water will be wiped off and left for 15 minutes. (2) The stratum corneum moisture content of the test site is measured using a skin characteristics evaluation device (Integral Co., Ltd., Conurage-Khazaka Corneometer CM825). The measured value is taken as the initial stratum corneum moisture content.

[0140] (3) Supply 200 μL of water to the test area. For the parts of the test area where the test specimen will not be attached, apply plenty of water and then wipe off the water. For the parts of the test area where the test specimen will be attached, apply the test specimen after supplying water and then peel off the support substrate. This will attach the thin film to the test area.

[0141] (4) After the operation in (3) above, peel off the thin film after 1 hour. Then, using the skin characteristic evaluation device described above, measure the stratum corneum moisture content in the area where the test piece is attached and in the area where the test piece is not attached. Compare each of the measured stratum corneum moisture content with the initial stratum corneum moisture content described above, and determine the increase in stratum corneum moisture content from the initial stratum corneum moisture content.

[0142] In evaluating the moisturizing function, a "○" was given if the increase in stratum corneum moisture content was greater in the areas where the test piece was applied than in the areas where it was not applied; a "△" was given if the increase in stratum corneum moisture content was the same in both the applied and unapplied areas of the test piece; and a "×" was given if the increase in stratum corneum moisture content was less in the applied areas than in the unapplied areas of the test piece.

[0143] (Evaluation results) Table 1 shows the measurement results for the thickness of the contact layer and antibacterial layer, the concentration of the antibacterial component and the added layer, and the occlusion rate for each example and comparative example. The occlusion rate is shown rounded to the first decimal place. Table 2 shows the evaluation results for the antibacterial function, the evaluation results for the moisturizing function, and the overall evaluation for each example and comparative example. In the overall evaluation, "○" indicates that all evaluations were "○", "△" indicates that no evaluations were "×" but some were "△", and "×" indicates that some evaluations were "×".

[0144] [Table 1]

[0145] [Table 2]

[0146] As shown in Tables 1 and 2, Examples 1 to 5 showed good evaluations in terms of bacterial growth inhibition, skin condition at each time interval at the application site of the thin film, and moisturizing function. In Examples 6-8, while the inhibition of bacterial growth and the condition of the skin at the application site of the thin film were good in the majority of samples, some samples showed poor results. In Examples 6-8, the thickness of the contact layer exceeded 1000 nm, so compared to Examples 1-5, it is thought that the antibacterial components of the antibacterial layer had difficulty reaching the culture medium, resulting in a weaker antibacterial effect. In addition, in Examples 6-8, some people felt tightness in their skin at the application site of the thin film. In Examples 6-8, the thickness of the contact layer exceeded 1000 nm, so compared to Examples 1-5, it is thought that the first surface of the contact layer did not conform well to the surface of the skin, resulting in skin tightness. Furthermore, in Example 6, some people felt dampness at the application site 6 hours after the application of the thin film. In Example 6, the occlusion rate exceeded 70%, so it is thought that dampness occurred when a long time had passed since the application of the thin film.

[0147] On the other hand, in Comparative Examples 1-3, bacterial growth inhibition was poor in the majority of samples, indicating insufficient inhibition of bacterial growth. In Comparative Examples 1 and 2, the layer containing the antibacterial component came into direct contact with the culture medium. Therefore, although the antibacterial effect was strong immediately after the application of the thin film, it disappeared in a short time, resulting in the confirmation of bacterial growth in the observation after one day. Furthermore, in Comparative Example 3, since it did not contain an antibacterial component, bacterial growth was not suppressed.

[0148] In Comparative Example 4, the weak inhibition of bacterial growth is thought to be due to the contact layer being thicker than 1000 nm, similar to Examples 6-8. Furthermore, in Comparative Example 4, stuffiness and tightness were felt at the majority of the application sites on the test specimens at 1 hour, 3 hours, and 6 hours after the application of the thin film. In Comparative Example 4, the total thickness of the thin film exceeded 5000 nm, and the occlusion rate exceeded 90%, so it is thought that the evaporation of moisture from the skin surface at the application sites of the thin film was strongly suppressed, resulting in stuffiness. In addition, it is thought that the thin film was too thick to conform well to the skin, resulting in a feeling of tightness. In contrast, Comparative Example 2 had an occlusion rate lower than 10%, which resulted in weaker moisturizing properties.

[0149] As described above in the embodiments and examples, the thin film and transfer sheet described above provide the following effects.

[0150] (1) When the thin film 10 is attached to the substrate, a contact layer 21 is located between the antibacterial layer 20 and the substrate, so that the antibacterial components contained in the antibacterial layer 20 do not come into contact with the substrate all at once. Therefore, the disappearance of the antibacterial effect in a short time immediately after the thin film 10 is attached is suppressed. In addition, by adjusting the amount of antibacterial components contained in the antibacterial layer 20, it is possible to control the strength of the antibacterial effect acting on a predetermined area to which the thin film 10 is attached, and it is possible to suppress excessive antibacterial effect. Furthermore, since the strong antibacterial effect in a short time is suppressed, if the substrate is skin, it is possible to protect the skin from the effects of the antibacterial effect and suppress skin irritation.

[0151] (2) The antibacterial layer 20 contains fragrance components, causing the thin film 10 to emit a fragrance. As a result, a masking effect against unpleasant odors is obtained, thereby enhancing the deodorizing effect. (3) The antibacterial layer 20, which contains the antibacterial component, and the contact layer 21, which does not contain the antibacterial component, are separate layers. Therefore, it is easy to form the structure of the thin film 10 in which the area without the antibacterial component is positioned between the area containing the antibacterial component and the adherend.

[0152] (4) Because the contact layer 21 contains a water-soluble polymer, the contact layer 21 dissolves due to moisture near the surface of the adherend, making it easier for the antibacterial components contained in the antibacterial layer 20 to reach the adherend. Therefore, the presence of moisture near the surface of the adherend can be used to promote the action of the antibacterial components on the adherend. In particular, when the adherend is skin, the action of the antibacterial components is promoted when sweat is produced, so that the antibacterial action works on the skin at the appropriate time, and odor generation is effectively suppressed.

[0153] (5) The thin film 10 is equipped with a cover layer 22, so that when the thin film 10 is attached to the substrate, the antibacterial layer 20 is covered by the cover layer 22. Therefore, the antibacterial and aromatic components contained in the antibacterial layer 20 are prevented from escaping to the opposite side of the substrate, thereby increasing the duration of the effects of these components.

[0154] (6) Because the cover layer contains fragrance components, when the thin film 10 is attached to the substrate, fragrance is emitted from the layer exposed to the outside air, thereby enhancing the odor masking effect. Consequently, the deodorizing effect is enhanced.

[0155] (7) Because the antibacterial layer 20 contains a compound that is both an antibacterial component and an aromatic component, the effects of each component can be obtained with an antibacterial layer of a simpler composition compared to the case where the antibacterial component and the aromatic component are separate compounds.

[0156] (8) By having the mass ratio of the antibacterial component contained in the thin film 10 to the total mass of the thin film 10 be between 50 ppm and 30%, a good antibacterial effect and its persistence can be obtained.

[0157] (9) The antibacterial layer 20 has a thickness of 20 nm or more and less than 5000 nm, which enhances the adhesion between the thin film 10 and the substrate, and also provides good strength to the antibacterial layer 20. Furthermore, it is easy to incorporate a sufficient amount of functional components into the antibacterial layer 20.

[0158] (10) The contact layer 21 has a thickness of 10 nm to 1000 nm, which improves the conformability of the first surface 11F to the adherend, and also facilitates the arrival of the antibacterial components contained in the antibacterial layer 20 to the adherend. Furthermore, good strength of the contact layer 21 can be obtained. In addition, if the contact layer 21 contains a water-soluble polymer, and the thickness of the contact layer 21 is within the above range, the contact layer 21 will dissolve more easily with water.

[0159] (11) Because the thickness of the contact layer 21 is smaller than the thickness of the antibacterial layer 20, the contact layer 21, which has the function of slowing down the arrival of the antibacterial component to the substrate, does not become too thick relative to the amount of antibacterial component contained in the antibacterial layer 20, so that the contact layer 21 has a thickness suitable for its function. Therefore, the antibacterial component contained in the antibacterial layer 20 acts on the substrate at an appropriate speed and for an appropriate duration.

[0160] Furthermore, the thinner the contact layer 21, the better the first surface 11F can conform to the surface shape of the adherend. Therefore, in a thin film 10 of a predetermined total thickness, a thinner contact layer 21 compared to the antibacterial layer 20 improves the adhesion between the thin film 10 and the adherend. Also, when the adherend is skin, the feeling of tightness in the skin at the point where the thin film 10 is attached is reduced. In addition, a thicker antibacterial layer 20 than the contact layer 21 makes it easier to achieve a good occlusion rate and enhances the moisturizing effect.

[0161] (12) The occlusion rate of the thin film 10 is between 5% and 70%, which allows the thin film 10 to moisturize the adherend, and when the adherend is skin, a good amount of water evaporation can be obtained at the site where the thin film 10 is applied. As a result, the homeostasis of the skin is more easily maintained.

[0162] (13) By including biocompatible materials in the constituent layers of the thin film 10, the suitability of the thin film 10 for application to living organisms is enhanced. (14) In the transfer sheet 30, the thin film 10 is supported by the support substrate 31, so deformation of the thin film 10 is suppressed and the thin film 10 is easier to handle.

[0163] [Differentiation] The above embodiment can be implemented with the following modifications. The thin film 10 has an antibacterial region containing an antibacterial component and a buffer region where the concentration of the antibacterial component is lower than that of the antibacterial region, and it is sufficient that the first surface 11F is included in the buffer region. The concentration of the antibacterial component is the mass of the antibacterial component per unit volume.

[0164] In other words, the antibacterial region and the buffer region do not have to be separated in layers as in the above embodiment, and the concentration of antibacterial components may gradually decrease from the antibacterial region to the buffer region. If the buffer region includes the first surface 11F and is in contact with the adherend, when the thin film 10 is attached to the adherend, the buffer region will be located between the antibacterial region, which contains a relatively large amount of antibacterial components, and the adherend. Therefore, the antibacterial components contained in the antibacterial region are prevented from coming into contact with the adherend all at once, and the disappearance of the antibacterial effect in a short time immediately after the thin film 10 is attached is prevented. [Explanation of symbols]

[0165] 10...Thin film, 11F...First side, 11R...Second side, 20...Antibacterial layer, 21...Contact layer, 22...Cover layer, 30...Transfer sheet, 31...Support substrate, 40...Transfer sheet container, 41...Packaging.

Claims

1. A thin film having a thickness of 10 nm to 5000 nm, comprising a first surface that is attached to a substrate, and a second surface opposite to the first surface, A transfer sheet comprising a support substrate for supporting the thin film, The antibacterial layer is an antibacterial area containing antibacterial components, A contact layer which is a buffer region that does not contain the antibacterial component, wherein the contact layer comes into contact with the adherend when the thin film is attached to the adherend, The antibacterial layer has a cover layer that covers the antibacterial layer on the side opposite to the contact layer, The first surface is included in the buffer region, The thickness of the contact layer is smaller than the thickness of the antibacterial layer. The aforementioned contact layer is made of a water-soluble polymer material. The second surface is included in the cover layer, and the second surface is in contact with the support substrate. Transfer sheet.

2. The contact layer has a thickness of 10 nm to 1000 nm. The transfer sheet according to claim 1.

3. The aforementioned cover layer contains fragrance components. The transfer sheet according to claim 1 or 2.

4. The occlusion rate, which is the ratio by which the amount of water evaporation at the location where the thin film is placed is reduced compared to the amount of evaporation when the thin film is not placed, is 5% or more and 70% or less. A transfer sheet according to any one of claims 1 to 3.

5. The aforementioned antibacterial layer contains fragrance components. A transfer sheet according to any one of claims 1 to 4.

6. The antibacterial layer contains a compound that is both an antibacterial component and a fragrance component. A transfer sheet according to any one of claims 1 to 5.

7. The antibacterial layer has a thickness of 20 nm or more and less than 5000 nm. A transfer sheet according to any one of claims 1 to 6.

8. The mass ratio of the antibacterial component contained in the thin film to the total mass of the thin film is 50 ppm or more and 30% or less. A transfer sheet according to any one of claims 1 to 7.

9. The thin film contains a biocompatible material. A transfer sheet according to any one of claims 1 to 8.

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