Aromatic heterocyclic pyrrolidone derivative and use thereof
By optimizing the structure of aromatic heterocycles and virrolidone compounds, a highly selective PI3K inhibitor was developed, which solved the shortcomings of existing inhibitors in target inhibitory activity and safety, and achieved significant improvement in biological activity. and selective effects.
WO2025003769A2PCT designated stage expired Publication Date: 2025-01-02HANGZHOU BIO CREATIVITY PHARM TECH CO LTD
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Patent Information
- Application Number
- PCT/IB2024/000435
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-06-12
- Filing Date
- 2024-07-01
- Publication Date
- 2025-01-02
AI Technical Summary
Technical Problem
The existing PI3K inhibitors have problems in target inhibitory activity and selectivity, pharmacokinetics and safety, which limits their further development.
Method used
A new aromatic heterocyclic and virrolidone compound and its pharmaceutically acceptable salt have been developed, which improves biological activity and selectivity by optimizing its structure, as a highly selective PI3K inhibitor for prevention Or treat diseases related to abnormal expression of PI3K signaling pathway.
Benefits of technology
It has achieved a significant improvement in the biological activity and selectivity of PI3K inhibitors, provided a broader application prospect, and solved the shortcomings of existing inhibitors in target inhibitory activity and safety.
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Abstract
Disclosed in the present invention is an aromatic heterocyclic pyrrolidone derivative having a new structure, which can be developed as an inhibitor targeting small molecule PI3Kγ. The PI3Kγ inhibitor has a high selectivity and a siginificant biological activity, and also has considerable potential in the prevention or treatment of diseases related to abnormal expression of the PI3Kγ signaling pathway.
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