Chemically modified mRNA for coding epidermal growth factor, construction method for mRNA, and use of mRNA

EGF mRNA is transcribed and synthesized through chemically modified mRNA technology, which promotes the production of physiological EGF protein in skin cells, solves the high cost and side effects of the recombinant protein EGF in the existing technology, achieves safe and efficient skin wound repair, and promotes rapid skin cells Proliferation and migration significantly improve wound healing efficiency.

WO2025007366A1PCT designated stage expired Publication Date: 2025-01-09ZHENHE PHARM (HANGZHOU) CO LTD
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Patent Information

Application Number
PCT/CN2023/107603
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-07-06
Filing Date
2023-07-15
Publication Date
2025-01-09

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Abstract

Provided are a chemically modified mRNA for coding an epidermal growth factor (EGF), a construction method for the mRNA, and a use of the mRNA. The construction method for a chemically modified mRNA for coding an EGF comprises the following steps: (1) transcribing and synthesizing an mRNA by taking a DNA sequence of a specific EGF as a template; and (2) carrying out tailing and chemical modification on the mRNA to obtain a chemically modified mRNA. Compared with a virus, a plasmid and a recombinant protein for the delivery of an EGF, a chemically modified mRNA preparation is safer and more effective and has higher cost performance. The defects of a recombinant protein EGF can be overcome, and rapid repair of skin wounds is promoted. The chemically modified mRNA is a novel gene therapy preparation, and can promote rapid repair of skin wounds under a safer and lower administration dosage.
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Citation Information

Patent Citations

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